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P98109 (LYAM3_SHEEP) Reviewed, UniProtKB/Swiss-Prot

Last modified March 6, 2013. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
P-selectin
Alternative name(s):
CD62 antigen-like family member P
CD62P antigen
Granule membrane protein 140
Short name=GMP-140
Leukocyte-endothelial cell adhesion molecule 3
Short name=LECAM3
Platelet activation dependent granule-external membrane protein
Short name=PADGEM
CD_antigen=CD62
Gene names
Name:SELP
OrganismOvis aries (Sheep)
Taxonomic identifier9940 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Caprinae › Ovis

Protein attributes

Sequence length769 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Ca2+-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with PSGL1.

Subunit structure

Interacts with SNX17. Interacts with PSGL1/SEPL and PODXL2 and mediates neutrophil adhesion and leukocyte rolling. This interaction requires the sialyl-Lewis X epitope of PSGL1 and PODXL2, and specific tyrosine sulfation on PSGL1 By similarity.

Subcellular location

Membrane; Single-pass type I membrane protein.

Sequence similarities

Belongs to the selectin/LECAM family.

Contains 1 C-type lectin domain.

Contains 1 EGF-like domain.

Contains 8 Sushi (CCP/SCR) domains.

Ontologies

Keywords
   Biological processCell adhesion
   Cellular componentMembrane
   DomainEGF-like domain
Repeat
Signal
Sushi
Transmembrane
Transmembrane helix
   LigandLectin
   PTMDisulfide bond
Glycoprotein
Gene Ontology (GO)
   Biological_processcell adhesion

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functioncarbohydrate binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3232 Potential
Chain33 – 769737P-selectin
PRO_0000017501

Regions

Topological domain33 – 717685Extracellular Potential
Transmembrane718 – 73417Helical; Potential
Topological domain735 – 76935Cytoplasmic Potential
Domain58 – 158101C-type lectin
Domain159 – 19537EGF-like
Domain198 – 25962Sushi 1
Domain260 – 32162Sushi 2
Domain322 – 38362Sushi 3
Domain384 – 44562Sushi 4
Domain446 – 50762Sushi 5
Domain508 – 56962Sushi 6
Domain579 – 64062Sushi 7
Domain641 – 70262Sushi 8
Region760 – 76910Interaction with SNX17 By similarity
Motif757 – 7604Endocytosis signal Probable

Amino acid modifications

Glycosylation541N-linked (GlcNAc...) Potential
Glycosylation801N-linked (GlcNAc...) Potential
Glycosylation1801N-linked (GlcNAc...) Potential
Glycosylation2121N-linked (GlcNAc...) Potential
Glycosylation2191N-linked (GlcNAc...) Potential
Glycosylation3471N-linked (GlcNAc...) Potential
Glycosylation3981N-linked (GlcNAc...) Potential
Glycosylation6041N-linked (GlcNAc...) Potential
Glycosylation6551N-linked (GlcNAc...) Potential
Glycosylation6621N-linked (GlcNAc...) Potential
Glycosylation6801N-linked (GlcNAc...) Potential
Disulfide bond60 ↔ 158 By similarity
Disulfide bond131 ↔ 150 By similarity
Disulfide bond163 ↔ 174 By similarity
Disulfide bond168 ↔ 183 By similarity
Disulfide bond185 ↔ 194 By similarity
Disulfide bond200 ↔ 244 By similarity
Disulfide bond230 ↔ 257 By similarity
Disulfide bond262 ↔ 306 By similarity
Disulfide bond292 ↔ 319 By similarity
Disulfide bond324 ↔ 368 By similarity
Disulfide bond354 ↔ 381 By similarity
Disulfide bond386 ↔ 430 By similarity
Disulfide bond416 ↔ 443 By similarity
Disulfide bond448 ↔ 492 By similarity
Disulfide bond478 ↔ 505 By similarity
Disulfide bond510 ↔ 554 By similarity
Disulfide bond540 ↔ 567 By similarity
Disulfide bond581 ↔ 625 By similarity
Disulfide bond611 ↔ 638 By similarity
Disulfide bond643 ↔ 687 By similarity
Disulfide bond673 ↔ 700 By similarity

Natural variations

Natural variant5661S → T.
Natural variant5791L → V.

Sequences

Sequence LengthMass (Da)Tools
P98109 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: 23E42575D60FAB15

FASTA76984,318
        10         20         30         40         50         60 
MASCPKAIWS WRFQRVVFRS VQLLCFSILI FELMTQKEVS AWTYHYSDKP YSWNYSRAFC 

        70         80         90        100        110        120 
QKYYTDLVAI QNKNEIAYLN ETIPYYNSYY WIGIRKIDNK WTWVGTKKTL TEEAENWADN 

       130        140        150        160        170        180 
EPNNKKNNQD CVEIYIKSPS APGKWNDEPC GKRKRALCYR ASCQDMSCSK QGECIETIGN 

       190        200        210        220        230        240 
YTCSCYPGFY GPECEYVREC GEFDLPQNVH MNCSHPLGNF SFKSQCSFHC AEGYALNGPR 

       250        260        270        280        290        300 
ELECLASGIW TNSPPQCVAV QCPALKSPEQ GSMSCFHSAK AFQHQSSCSF SCEEGFTLVG 

       310        320        330        340        350        360 
PEVVHCTALG VWTAPTPVCK AIACESLESP VHGSMDCSPS PRAFQYNTSC SFRCAEGFTL 

       370        380        390        400        410        420 
RGADTVRCAD SGEWTAPAPV CQALQCQDLP TSNKARVNCS HPFGDFRYQS TCSFTCDEGS 

       430        440        450        460        470        480 
FLVGASVLQC LDTGNWDAPF PECQAVTCAP LPNPQNGEKT CVQPLGGSSY KSTCWFTCHE 

       490        500        510        520        530        540 
GFSLSGPERL DCTPSGHWTG SPPTCEASKC PELSAPEQGS LDCPDTHGEF IVGSICHFSC 

       550        560        570        580        590        600 
NEGLKLEGSN HVECTASGRW TAPPPSCKVD TVSAPAPGLR CPSLIAPNQG TMSCQHHLRN 

       610        620        630        640        650        660 
FGLNTTCHFG CKAGFTLMGE SALQCRPSRQ WTAVAPTCRA VKCSKLPVTE PIVMNCSNPW 

       670        680        690        700        710        720 
GNFSYGSTCS FHCPEGQLLN GSERTACQEN GQWSTTMPTC QAGPLTIQEA LTYIGGAAAG 

       730        740        750        760 
TTGLVTSSIL LALLRRRRRQ KDDGKSPLNP QSHLGTYGVF TNAAFDPSP

« Hide

References

[1]Burns S.A., Neufeld E.J., Donady J.J.
Submitted (JUL-1994) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Heart.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		L34270 mRNA. Translation: AAB59261.1.
RefSeqNP_001009295.1. NM_001009295.1.
UniGeneOar.547.

3D structure databases

ProteinModelPortalP98109.
SMRP98109. Positions 42-199.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID443305.

Organism-specific databases

CTD6403.

Phylogenomic databases

HOVERGENHBG052375.

Family and domain databases

Gene3D3.10.100.10. 1 hit.
InterProIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
IPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR002396. Selectin_superfamily.
IPR000436. Sushi_SCR_CCP.
[Graphical view]
PfamPF00059. Lectin_C. 1 hit.
PF00084. Sushi. 8 hits.
[Graphical view]
PRINTSPR00343. SELECTIN.
SMARTSM00032. CCP. 8 hits.
SM00034. CLECT. 1 hit.
SM00181. EGF. 1 hit.
[Graphical view]
SUPFAMSSF56436. C-type_lectin_fold. 1 hit.
SSF57535. Complement_control_module. 8 hits.
PROSITEPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
PS50923. SUSHI. 8 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameLYAM3_SHEEP
AccessionPrimary (citable) accession number: P98109
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: March 6, 2013
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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