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P98107 (LYAM2_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
E-selectin
Alternative name(s):
CD62 antigen-like family member E
Endothelial leukocyte adhesion molecule 1
Short name=ELAM-1
Leukocyte-endothelial cell adhesion molecule 2
Short name=LECAM2
CD_antigen=CD62E
Gene names
Name:SELE
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length485 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with PSGL1/SELPLG. May have a role in capillary morphogenesis. Ref.1

Subunit structure

Interacts with PSGL1/SELPLG and PODXL2 through the sialyl Lewis X epitope. PSGL1 sulfation appears not to be required for this interaction By similarity.

Subcellular location

Membrane; Single-pass type I membrane protein.

Sequence similarities

Belongs to the selectin/LECAM family.

Contains 1 C-type lectin domain.

Contains 1 EGF-like domain.

Contains 4 Sushi (CCP/SCR) domains.

Ontologies

Keywords
   Biological processCell adhesion
   Cellular componentMembrane
   DomainEGF-like domain
Repeat
Signal
Sushi
Transmembrane
Transmembrane helix
   LigandLectin
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell adhesion

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functioncarbohydrate binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 By similarity
Chain23 – 485463E-selectin
PRO_0000017489

Regions

Topological domain23 – 430408Extracellular Potential
Transmembrane431 – 45323Helical; Potential
Topological domain454 – 48532Cytoplasmic Potential
Domain23 – 140118C-type lectin
Domain141 – 17636EGF-like
Domain179 – 23961Sushi 1
Domain240 – 30162Sushi 2
Domain302 – 36463Sushi 3
Domain365 – 42359Sushi 4

Amino acid modifications

Glycosylation611N-linked (GlcNAc...) Potential
Glycosylation791N-linked (GlcNAc...) Potential
Glycosylation881N-linked (GlcNAc...) Potential
Glycosylation1611N-linked (GlcNAc...) Potential
Glycosylation2031N-linked (GlcNAc...) Potential
Glycosylation2651N-linked (GlcNAc...) Potential
Glycosylation3121N-linked (GlcNAc...) Potential
Glycosylation3161N-linked (GlcNAc...) Potential
Glycosylation3791N-linked (GlcNAc...) Potential
Glycosylation4011N-linked (GlcNAc...) Potential
Disulfide bond41 ↔ 139 By similarity
Disulfide bond112 ↔ 131 By similarity
Disulfide bond144 ↔ 155 By similarity
Disulfide bond149 ↔ 164 By similarity
Disulfide bond166 ↔ 175 By similarity
Disulfide bond181 ↔ 224 By similarity
Disulfide bond210 ↔ 237 By similarity
Disulfide bond242 ↔ 286 By similarity
Disulfide bond272 ↔ 299 By similarity
Disulfide bond304 ↔ 349 By similarity
Disulfide bond335 ↔ 362 By similarity
Disulfide bond367 ↔ 408 By similarity
Disulfide bond394 ↔ 421 By similarity

Sequences

Sequence LengthMass (Da)Tools
P98107 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: AE931C9B521E3904

FASTA48553,200
        10         20         30         40         50         60 
MIVSQYLSAL TFVLLLFKES RTWSYHASTE MMTFEEARDY CQKTYTALVA IQNQEEIEYL 

        70         80         90        100        110        120 
NSTFSYSPSY YWIGIRKING TWTWIGTNKS LTKEATNWAP GEPNNKQSDE DCVEIYIKRE 

       130        140        150        160        170        180 
KDSGKWNDEK CTKQKLALCY KAACNPTPCG SHGECVETIN NYTCQCHPGF KGLKCEQVVT 

       190        200        210        220        230        240 
CPAQKHPEHG HLVCNPLGKF TYNSSCSISC AEGYLPSSTE ATRCMSSGEW STPLPKCNVV 

       250        260        270        280        290        300 
KCDALSNLDN GVVNCSPNHG SLPWNTTCTF ECQEGYKLTG PQHLQCTSSG IWDNKQPTCK 

       310        320        330        340        350        360 
AVSCAAISHP QNGTVNCSHS VVGDFAFKSS CHFTCAEGFT LQGPTQVECT AQGQWTQRVP 

       370        380        390        400        410        420 
VCEVVRCSRL DVSGKLNMNC SGEPVLGTEC TFACPERWTL NGSVVLTCGA TGHWSGMLPT 

       430        440        450        460        470        480 
CEAPTVSQTP LAVGLSTAGV SLVTIPSFLF WLLKRLQKKA KKFSPASSCS SLKSNGCYST 


PSKLI

« Hide

References

« Hide 'large scale' references
[1]"A role for sialyl Lewis-X/A glycoconjugates in capillary morphogenesis."
Nguyen M., Strubel N.A., Bischoff J.
Nature 365:267-269(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
Tissue: Adrenal gland.
[2]NIH - Mammalian Gene Collection (MGC) project
Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Fetal skin.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		L12039 mRNA. Translation: AAA02991.1.
BC149190 mRNA. Translation: AAI49191.1.
IPIIPI00691959.
PIRS36772.
RefSeqNP_776606.1. NM_174181.2.
UniGeneBt.197.

3D structure databases

ProteinModelPortalP98107.
SMRP98107. Positions 23-179.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000009612; ENSBTAP00000009612; ENSBTAG00000007307.
GeneID281484.
KEGGbta:281484.

Organism-specific databases

CTD6401.

Phylogenomic databases

eggNOGNOG242963.
GeneTreeENSGT00700000104229.
HOGENOMHOG000236254.
HOVERGENHBG052375.
InParanoidP98107.
KOK06494.
OrthoDBEOG4JT04Z.

Gene expression databases

ArrayExpressP98107.

Family and domain databases

Gene3D3.10.100.10. 1 hit.
InterProIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
IPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR002396. Selectin_superfamily.
IPR000436. Sushi_SCR_CCP.
[Graphical view]
PfamPF00008. EGF. 1 hit.
PF00059. Lectin_C. 1 hit.
PF00084. Sushi. 4 hits.
[Graphical view]
PRINTSPR00343. SELECTIN.
SMARTSM00032. CCP. 4 hits.
SM00034. CLECT. 1 hit.
SM00181. EGF. 1 hit.
[Graphical view]
SUPFAMSSF56436. C-type_lectin_fold. 1 hit.
SSF57535. Complement_control_module. 4 hits.
PROSITEPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
PS50923. SUSHI. 4 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio20805459.

Entry information

Entry nameLYAM2_BOVIN
AccessionPrimary (citable) accession number: P98107
Secondary accession number(s): A6QP78
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: April 3, 2013
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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