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Protein

P-selectin

Gene

Selp

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Ca2+-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with PSGL1 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • leukocyte migration Source: RGD
  • positive regulation of cell adhesion Source: RGD
  • regulation of cellular extravasation Source: RGD
  • response to lipopolysaccharide Source: RGD
  • response to organic cyclic compound Source: RGD
  • single organismal cell-cell adhesion Source: RGD
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
P-selectin
Alternative name(s):
CD62 antigen-like family member P
Granule membrane protein 140
Short name:
GMP-140
Leukocyte-endothelial cell adhesion molecule 3
Short name:
LECAM3
Platelet activation dependent granule-external membrane protein
Short name:
PADGEM
CD_antigen: CD62P
Gene namesi
Name:Selp
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3656. Selp.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini42 – 709ExtracellularSequence analysisAdd BLAST668
Transmembranei710 – 733HelicalSequence analysisAdd BLAST24
Topological domaini734 – 768CytoplasmicSequence analysisAdd BLAST35

GO - Cellular componenti

  • external side of plasma membrane Source: RGD
  • extracellular space Source: RGD
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 41Sequence analysisAdd BLAST41
ChainiPRO_000001750042 – 768P-selectinAdd BLAST727

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi45N-linked (GlcNAc...)Sequence analysis1
Glycosylationi54N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi60 ↔ 158By similarity
Glycosylationi107N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi131 ↔ 150By similarity
Disulfide bondi168 ↔ 183By similarity
Disulfide bondi185 ↔ 194By similarity
Disulfide bondi200 ↔ 244By similarity
Glycosylationi212N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi230 ↔ 257By similarity
Disulfide bondi262 ↔ 306By similarity
Disulfide bondi292 ↔ 319By similarity
Disulfide bondi324 ↔ 368By similarity
Glycosylationi347N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi354 ↔ 381By similarity
Disulfide bondi386 ↔ 430By similarity
Disulfide bondi416 ↔ 443By similarity
Disulfide bondi448 ↔ 492By similarity
Glycosylationi456N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi478 ↔ 505By similarity
Disulfide bondi510 ↔ 554By similarity
Disulfide bondi540 ↔ 567By similarity
Disulfide bondi580 ↔ 624By similarity
Glycosylationi603N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi610 ↔ 637By similarity
Disulfide bondi642 ↔ 686By similarity
Glycosylationi654N-linked (GlcNAc...)Sequence analysis1
Glycosylationi661N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi672 ↔ 699By similarity
Glycosylationi679N-linked (GlcNAc...)Sequence analysis1
Lipidationi745S-palmitoyl cysteineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP98106.
PRIDEiP98106.

Expressioni

Tissue specificityi

Expressed in all tissues examined: spleen, lung, brain, liver, heart, kidney, thymus and small intestine.

Inductioni

By acute inflammation.Curated

Interactioni

Subunit structurei

Interacts with SNX17. Interacts with PSGL1/SEPL and PODXL2 and mediates neutrophil adhesion and leukocyte rolling. This interaction requires the sialyl-Lewis X epitope of PSGL1 and PODXL2, and specific tyrosine sulfation on PSGL1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003759.

Structurei

3D structure databases

ProteinModelPortaliP98106.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini58 – 158C-type lectinPROSITE-ProRule annotationAdd BLAST101
Domaini159 – 195EGF-likePROSITE-ProRule annotationAdd BLAST37
Domaini198 – 259Sushi 1PROSITE-ProRule annotationAdd BLAST62
Domaini260 – 321Sushi 2PROSITE-ProRule annotationAdd BLAST62
Domaini322 – 383Sushi 3PROSITE-ProRule annotationAdd BLAST62
Domaini384 – 445Sushi 4PROSITE-ProRule annotationAdd BLAST62
Domaini446 – 507Sushi 5PROSITE-ProRule annotationAdd BLAST62
Domaini508 – 569Sushi 6PROSITE-ProRule annotationAdd BLAST62
Domaini578 – 639Sushi 7PROSITE-ProRule annotationAdd BLAST62
Domaini640 – 701Sushi 8PROSITE-ProRule annotationAdd BLAST62

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni759 – 768Interaction with SNX17By similarity10

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi756 – 759Endocytosis signalCurated4

Sequence similaritiesi

Belongs to the selectin/LECAM family.Curated
Contains 1 C-type lectin domain.PROSITE-ProRule annotation
Contains 1 EGF-like domain.PROSITE-ProRule annotation
Contains 8 Sushi (CCP/SCR) domains.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal, Sushi, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IS44. Eukaryota.
ENOG410Y5JF. LUCA.
HOGENOMiHOG000236254.
HOVERGENiHBG052375.
InParanoidiP98106.
KOiK06496.
PhylomeDBiP98106.

Family and domain databases

CDDicd00033. CCP. 8 hits.
Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR018378. C-type_lectin_CS.
IPR016187. CTDL_fold.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR002396. Selectin_superfamily.
IPR000436. Sushi_SCR_CCP_dom.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
PF00084. Sushi. 8 hits.
[Graphical view]
PRINTSiPR00343. SELECTIN.
SMARTiSM00032. CCP. 8 hits.
SM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
SSF57535. SSF57535. 8 hits.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
PS50923. SUSHI. 8 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P98106-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGCPKGSWK PRLRSVVLGA AQLIWLSALI SELVNRKKVA TWTYNYSTKA
60 70 80 90 100
YSWNNSRAFC KRHFTDLVAI QNKNEIAHLN DVIPYVNSYY WIGIRKINNK
110 120 130 140 150
WTWVGTNKTL TAEAENWADN EPNNKRNNQD CVEIYIKSNS APGKWNDEPC
160 170 180 190 200
FKRKRALCYT ASCQDMSCNS QGERIETIGS YTCSCYPGFY GPECEYVQEC
210 220 230 240 250
GKFDIPQHVL MNCSHPLGDF SFSSQCTFSC PEGYDLNGPS EMQCLASGIW
260 270 280 290 300
TNNPPQCKAV QCQSLEAPLH GTMDCTHPLA AFAYDSSCKF ECQPGYRMRG
310 320 330 340 350
SDILHCTDSG QWSEPLPTCE AIACEPLESP LHGSMDCFPS TGAFGYNSSC
360 370 380 390 400
TFRCTEGFVL MGNDAIHCAD LGQWTAPAPV CEALQCQEFP VPSKAQVSCS
410 420 430 440 450
DPFGPLKYQS ACSFSCDEGS LLVGASVIRC LATGHWSEAP PECQAVSCTP
460 470 480 490 500
LLSPENGTMT CIQPLGHSNY KSTCQFMCDE GFYLSGPERL DCSPSGHWTG
510 520 530 540 550
SPPMCEAIKC PEIFAPEQGS LDCSHVHGEF SVGSTCHFSC NEEFELLGSR
560 570 580 590 600
NVECTVSGRW SAPPPTCKGV TSLPVPSVRC PALTTPGQGT MSCRHHLESF
610 620 630 640 650
GPNTTCYFGC KTGFTLRGAN SLRCGASGQW TAVTPVCRAV KCSELHMDTA
660 670 680 690 700
VAMNCSNPWG NFSYGSTCAF HCPEGQSLNG SARTTCGEDG HWSDAMPTCQ
710 720 730 740 750
AGTLTIQEAL TYLGGALAST SGLAVGGTLL ALLRKRLRKK DDGKCPLNPH
760
SHLGTYGVFT NAAYDPTP
Length:768
Mass (Da):83,517
Last modified:February 1, 1996 - v1
Checksum:i26FD7E8A5F3F1316
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L23088 mRNA. Translation: AAA60325.1.
PIRiI53821.
RefSeqiNP_037246.1. NM_013114.1.
UniGeneiRn.10012.

Genome annotation databases

GeneIDi25651.
KEGGirno:25651.
UCSCiRGD:3656. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L23088 mRNA. Translation: AAA60325.1.
PIRiI53821.
RefSeqiNP_037246.1. NM_013114.1.
UniGeneiRn.10012.

3D structure databases

ProteinModelPortaliP98106.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003759.

Proteomic databases

PaxDbiP98106.
PRIDEiP98106.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi25651.
KEGGirno:25651.
UCSCiRGD:3656. rat.

Organism-specific databases

CTDi6403.
RGDi3656. Selp.

Phylogenomic databases

eggNOGiENOG410IS44. Eukaryota.
ENOG410Y5JF. LUCA.
HOGENOMiHOG000236254.
HOVERGENiHBG052375.
InParanoidiP98106.
KOiK06496.
PhylomeDBiP98106.

Miscellaneous databases

PROiP98106.

Family and domain databases

CDDicd00033. CCP. 8 hits.
Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR018378. C-type_lectin_CS.
IPR016187. CTDL_fold.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR002396. Selectin_superfamily.
IPR000436. Sushi_SCR_CCP_dom.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
PF00084. Sushi. 8 hits.
[Graphical view]
PRINTSiPR00343. SELECTIN.
SMARTiSM00032. CCP. 8 hits.
SM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
SSF57535. SSF57535. 8 hits.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
PS50923. SUSHI. 8 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLYAM3_RAT
AccessioniPrimary (citable) accession number: P98106
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 30, 2016
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.