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Protein

E-selectin

Gene

Sele

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with PSGL1/SELPLG. May have a role in capillary morphogenesis (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • cell adhesion Source: RGD
  • inflammatory response Source: RGD
  • leukocyte migration Source: RGD
  • response to cytokine Source: RGD

Keywordsi

Biological processCell adhesion
LigandLectin

Enzyme and pathway databases

ReactomeiR-RNO-202733. Cell surface interactions at the vascular wall.

Names & Taxonomyi

Protein namesi
Recommended name:
E-selectin
Alternative name(s):
CD62 antigen-like family member E
Endothelial leukocyte adhesion molecule 1
Short name:
ELAM-1
Leukocyte-endothelial cell adhesion molecule 2
Short name:
LECAM2
CD_antigen: CD62E
Gene namesi
Name:Sele
Synonyms:Elam-1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 13

Organism-specific databases

RGDi3654. Sele.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 494ExtracellularSequence analysisAdd BLAST473
Transmembranei495 – 516HelicalSequence analysisAdd BLAST22
Topological domaini517 – 549CytoplasmicSequence analysisAdd BLAST33

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2554.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000001749622 – 549E-selectinAdd BLAST528

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi25N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi40 ↔ 138By similarity
Glycosylationi60N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi111 ↔ 130By similarity
Disulfide bondi143 ↔ 154By similarity
Glycosylationi145N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi148 ↔ 163By similarity
Disulfide bondi165 ↔ 174By similarity
Disulfide bondi180 ↔ 225By similarity
Glycosylationi192N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi203N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi210 ↔ 238By similarity
Disulfide bondi243 ↔ 287By similarity
Glycosylationi266N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi273 ↔ 300By similarity
Disulfide bondi305 ↔ 350By similarity
Glycosylationi313N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi320N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi333N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi336 ↔ 363By similarity
Disulfide bondi368 ↔ 413By similarity
Disulfide bondi399 ↔ 426By similarity
Disulfide bondi431 ↔ 472By similarity
Glycosylationi441N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi458 ↔ 485By similarity
Glycosylationi465N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP98105.
PRIDEiP98105.

Expressioni

Gene expression databases

BgeeiENSRNOG00000002723.
ExpressionAtlasiP98105. baseline and differential.
GenevisibleiP98105. RN.

Interactioni

Subunit structurei

Interacts with PSGL1/SELPLG and PODXL2 through the sialyl Lewis X epitope. PSGL1 sulfation appears not to be required for this interaction (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000034797.

Chemistry databases

BindingDBiP98105.

Structurei

3D structure databases

ProteinModelPortaliP98105.
SMRiP98105.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 139C-type lectinPROSITE-ProRule annotationAdd BLAST118
Domaini140 – 175EGF-likePROSITE-ProRule annotationAdd BLAST36
Domaini178 – 240Sushi 1PROSITE-ProRule annotationAdd BLAST63
Domaini241 – 302Sushi 2PROSITE-ProRule annotationAdd BLAST62
Domaini303 – 365Sushi 3PROSITE-ProRule annotationAdd BLAST63
Domaini366 – 428Sushi 4PROSITE-ProRule annotationAdd BLAST63
Domaini429 – 487Sushi 5PROSITE-ProRule annotationAdd BLAST59

Sequence similaritiesi

Belongs to the selectin/LECAM family.Curated

Keywords - Domaini

EGF-like domain, Repeat, Signal, Sushi, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
GeneTreeiENSGT00870000136398.
HOGENOMiHOG000236254.
HOVERGENiHBG052375.
InParanoidiP98105.
KOiK06494.
OrthoDBiEOG091G04KC.

Family and domain databases

CDDicd00033. CCP. 5 hits.
cd03592. CLECT_selectins_like. 1 hit.
Gene3Di3.10.100.10. 1 hit.
InterProiView protein in InterPro
IPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR018378. C-type_lectin_CS.
IPR016187. CTDL_fold.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR033991. Selectin_CTLD.
IPR002396. Selectin_superfamily.
IPR000436. Sushi_SCR_CCP_dom.
PfamiView protein in Pfam
PF00008. EGF. 1 hit.
PF00059. Lectin_C. 1 hit.
PF00084. Sushi. 5 hits.
PRINTSiPR00343. SELECTIN.
SMARTiView protein in SMART
SM00032. CCP. 5 hits.
SM00034. CLECT. 1 hit.
SM00181. EGF. 2 hits.
SUPFAMiSSF56436. SSF56436. 1 hit.
SSF57535. SSF57535. 5 hits.
PROSITEiView protein in PROSITE
PS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
PS50923. SUSHI. 5 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P98105-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNASCFLSAL TFVLLIGKSI AWYYNASSEL MTYDEASAYC QRDYTHLVAI
60 70 80 90 100
QNKEEINYLN STLRYSPSYY WIGIRKVNNV WIWVGTQKPL TEEAKNWAPG
110 120 130 140 150
EPNNKQRNED CVEIYIQRPK DSGMWNDERC DKKKLALCYT ASCTNTSCSG
160 170 180 190 200
HGECVETINS YTCKCHPGFL GPKCDQVVTC QEQEYPDHGS LNCTHPFGLF
210 220 230 240 250
SYNSSCSFSC ERGYVPSSME TTVRCTSSGE WSAPAPACHV VECKALTQPA
260 270 280 290 300
HGVRKCSSNP GSYPWNTTCT FDCEEGYRRV GAQNLQCTSS GVWDNEKPSC
310 320 330 340 350
KAVTCDAIPR PQNGSVSCSN STAGALAFKS SCNFTCEHSF TLQGPAQVEC
360 370 380 390 400
SAQGQWTPQI PVCKASQCEA LSAPQRGHMK CLPSASAPFQ SGSSCKFSCD
410 420 430 440 450
EGFELKGSRR LQCGPRGEWD SEKPTCAGVQ CSSLDLPGKM NMSCSGPAVF
460 470 480 490 500
GTVCEFTCPE GWTLNGSSIL TCGATGRWSA MLPTCEAPAN PPRPLVVALS
510 520 530 540
VAATSLLTLS SLIYVLKRFF WKKAKKFVPA SSCQSLQSFE NYQGPSYII
Length:549
Mass (Da):60,080
Last modified:February 1, 1996 - v1
Checksum:i85CEECDB7B0144C8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L25527 mRNA. Translation: AAA41113.1.
RefSeqiNP_620234.1. NM_138879.1.
UniGeneiRn.10359.

Genome annotation databases

EnsembliENSRNOT00000076757; ENSRNOP00000068171; ENSRNOG00000002723.
GeneIDi25544.
KEGGirno:25544.
UCSCiRGD:3654. rat.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiLYAM2_RAT
AccessioniPrimary (citable) accession number: P98105
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: May 10, 2017
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families