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Protein

E-selectin

Gene

Sele

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with PSGL1/SELPLG. May have a role in capillary morphogenesis (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • cell adhesion Source: RGD
  • inflammatory response Source: RGD
  • leukocyte migration Source: RGD
  • response to cytokine Source: RGD
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Lectin

Enzyme and pathway databases

ReactomeiR-RNO-202733. Cell surface interactions at the vascular wall.

Names & Taxonomyi

Protein namesi
Recommended name:
E-selectin
Alternative name(s):
CD62 antigen-like family member E
Endothelial leukocyte adhesion molecule 1
Short name:
ELAM-1
Leukocyte-endothelial cell adhesion molecule 2
Short name:
LECAM2
CD_antigen: CD62E
Gene namesi
Name:Sele
Synonyms:Elam-1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 13

Organism-specific databases

RGDi3654. Sele.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 494473ExtracellularSequence analysisAdd
BLAST
Transmembranei495 – 51622HelicalSequence analysisAdd
BLAST
Topological domaini517 – 54933CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL2554.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence analysisAdd
BLAST
Chaini22 – 549528E-selectinPRO_0000017496Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi25 – 251N-linked (GlcNAc...)Sequence analysis
Disulfide bondi40 ↔ 138By similarity
Glycosylationi60 – 601N-linked (GlcNAc...)Sequence analysis
Disulfide bondi111 ↔ 130By similarity
Disulfide bondi143 ↔ 154By similarity
Glycosylationi145 – 1451N-linked (GlcNAc...)Sequence analysis
Disulfide bondi148 ↔ 163By similarity
Disulfide bondi165 ↔ 174By similarity
Disulfide bondi180 ↔ 225By similarity
Glycosylationi192 – 1921N-linked (GlcNAc...)Sequence analysis
Glycosylationi203 – 2031N-linked (GlcNAc...)Sequence analysis
Disulfide bondi210 ↔ 238By similarity
Disulfide bondi243 ↔ 287By similarity
Glycosylationi266 – 2661N-linked (GlcNAc...)Sequence analysis
Disulfide bondi273 ↔ 300By similarity
Disulfide bondi305 ↔ 350By similarity
Glycosylationi313 – 3131N-linked (GlcNAc...)Sequence analysis
Glycosylationi320 – 3201N-linked (GlcNAc...)Sequence analysis
Glycosylationi333 – 3331N-linked (GlcNAc...)Sequence analysis
Disulfide bondi336 ↔ 363By similarity
Disulfide bondi368 ↔ 413By similarity
Disulfide bondi399 ↔ 426By similarity
Disulfide bondi431 ↔ 472By similarity
Glycosylationi441 – 4411N-linked (GlcNAc...)Sequence analysis
Disulfide bondi458 ↔ 485By similarity
Glycosylationi465 – 4651N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP98105.
PRIDEiP98105.

Expressioni

Gene expression databases

BgeeiENSRNOG00000002723.
ExpressionAtlasiP98105. baseline and differential.
GenevisibleiP98105. RN.

Interactioni

Subunit structurei

Interacts with PSGL1/SELPLG and PODXL2 through the sialyl Lewis X epitope. PSGL1 sulfation appears not to be required for this interaction (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000034797.

Chemistry

BindingDBiP98105.

Structurei

3D structure databases

ProteinModelPortaliP98105.
SMRiP98105. Positions 22-178.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 139118C-type lectinPROSITE-ProRule annotationAdd
BLAST
Domaini140 – 17536EGF-likePROSITE-ProRule annotationAdd
BLAST
Domaini178 – 24063Sushi 1PROSITE-ProRule annotationAdd
BLAST
Domaini241 – 30262Sushi 2PROSITE-ProRule annotationAdd
BLAST
Domaini303 – 36563Sushi 3PROSITE-ProRule annotationAdd
BLAST
Domaini366 – 42863Sushi 4PROSITE-ProRule annotationAdd
BLAST
Domaini429 – 48759Sushi 5PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the selectin/LECAM family.Curated
Contains 1 C-type lectin domain.PROSITE-ProRule annotation
Contains 1 EGF-like domain.PROSITE-ProRule annotation
Contains 5 Sushi (CCP/SCR) domains.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal, Sushi, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
GeneTreeiENSGT00760000118803.
HOGENOMiHOG000236254.
HOVERGENiHBG052375.
InParanoidiP98105.
KOiK06494.
OrthoDBiEOG091G04KC.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR002396. Selectin_superfamily.
IPR000436. Sushi_SCR_CCP_dom.
[Graphical view]
PfamiPF00008. EGF. 1 hit.
PF00059. Lectin_C. 1 hit.
PF00084. Sushi. 5 hits.
[Graphical view]
PRINTSiPR00343. SELECTIN.
SMARTiSM00032. CCP. 5 hits.
SM00034. CLECT. 1 hit.
SM00181. EGF. 2 hits.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
SSF57535. SSF57535. 5 hits.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
PS50923. SUSHI. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P98105-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNASCFLSAL TFVLLIGKSI AWYYNASSEL MTYDEASAYC QRDYTHLVAI
60 70 80 90 100
QNKEEINYLN STLRYSPSYY WIGIRKVNNV WIWVGTQKPL TEEAKNWAPG
110 120 130 140 150
EPNNKQRNED CVEIYIQRPK DSGMWNDERC DKKKLALCYT ASCTNTSCSG
160 170 180 190 200
HGECVETINS YTCKCHPGFL GPKCDQVVTC QEQEYPDHGS LNCTHPFGLF
210 220 230 240 250
SYNSSCSFSC ERGYVPSSME TTVRCTSSGE WSAPAPACHV VECKALTQPA
260 270 280 290 300
HGVRKCSSNP GSYPWNTTCT FDCEEGYRRV GAQNLQCTSS GVWDNEKPSC
310 320 330 340 350
KAVTCDAIPR PQNGSVSCSN STAGALAFKS SCNFTCEHSF TLQGPAQVEC
360 370 380 390 400
SAQGQWTPQI PVCKASQCEA LSAPQRGHMK CLPSASAPFQ SGSSCKFSCD
410 420 430 440 450
EGFELKGSRR LQCGPRGEWD SEKPTCAGVQ CSSLDLPGKM NMSCSGPAVF
460 470 480 490 500
GTVCEFTCPE GWTLNGSSIL TCGATGRWSA MLPTCEAPAN PPRPLVVALS
510 520 530 540
VAATSLLTLS SLIYVLKRFF WKKAKKFVPA SSCQSLQSFE NYQGPSYII
Length:549
Mass (Da):60,080
Last modified:February 1, 1996 - v1
Checksum:i85CEECDB7B0144C8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L25527 mRNA. Translation: AAA41113.1.
RefSeqiNP_620234.1. NM_138879.1.
UniGeneiRn.10359.

Genome annotation databases

EnsembliENSRNOT00000076757; ENSRNOP00000068171; ENSRNOG00000002723.
GeneIDi25544.
KEGGirno:25544.
UCSCiRGD:3654. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L25527 mRNA. Translation: AAA41113.1.
RefSeqiNP_620234.1. NM_138879.1.
UniGeneiRn.10359.

3D structure databases

ProteinModelPortaliP98105.
SMRiP98105. Positions 22-178.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000034797.

Chemistry

BindingDBiP98105.
ChEMBLiCHEMBL2554.

Proteomic databases

PaxDbiP98105.
PRIDEiP98105.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000076757; ENSRNOP00000068171; ENSRNOG00000002723.
GeneIDi25544.
KEGGirno:25544.
UCSCiRGD:3654. rat.

Organism-specific databases

CTDi6401.
RGDi3654. Sele.

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
GeneTreeiENSGT00760000118803.
HOGENOMiHOG000236254.
HOVERGENiHBG052375.
InParanoidiP98105.
KOiK06494.
OrthoDBiEOG091G04KC.

Enzyme and pathway databases

ReactomeiR-RNO-202733. Cell surface interactions at the vascular wall.

Miscellaneous databases

PROiP98105.

Gene expression databases

BgeeiENSRNOG00000002723.
ExpressionAtlasiP98105. baseline and differential.
GenevisibleiP98105. RN.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR002396. Selectin_superfamily.
IPR000436. Sushi_SCR_CCP_dom.
[Graphical view]
PfamiPF00008. EGF. 1 hit.
PF00059. Lectin_C. 1 hit.
PF00084. Sushi. 5 hits.
[Graphical view]
PRINTSiPR00343. SELECTIN.
SMARTiSM00032. CCP. 5 hits.
SM00034. CLECT. 1 hit.
SM00181. EGF. 2 hits.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
SSF57535. SSF57535. 5 hits.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
PS50923. SUSHI. 5 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLYAM2_RAT
AccessioniPrimary (citable) accession number: P98105
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: September 7, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.