P98095 (FBLN2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Fibulin-2
Short name=FIBL-2

Gene names

Name:

FBLN2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1184 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Its binding to fibronectin and some other ligands is calcium dependent.
Subunit structure	Homotrimer; disulfide-linked. Interacts with LAMA2 By similarity.
Subcellular location	Secreted › extracellular space › extracellular matrix.
Tissue specificity	Component of both basement membranes and other connective tissues. Expressed in heart, placenta and ovary.
Developmental stage	Widely expressed during embryonic development. Primarily detected within the neuropithelium, spinal ganglia and peripheral nerves. Ref.5
Post-translational modification	O-glycosylated with core 1 or possibly core 8 glycans. It is unsure if the O-glycosylation is on Thr-347 or Ser-348. Ref.8
Sequence similarities	Belongs to the fibulin family. Contains 3 anaphylatoxin-like domains. Contains 10 EGF-like domains.

Ontologies

Keywords
Cellular component	Extracellular matrix Secreted
Coding sequence diversity	Alternative splicing Polymorphism
Domain	EGF-like domain Repeat Signal
Ligand	Calcium
PTM	Disulfide bond Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	positive regulation of cell-substrate adhesion Inferred from electronic annotation. Source: Compara
Cellular_component	proteinaceous extracellular matrix Traceable author statement Ref.1. Source: ProtInc
Molecular_function	calcium ion binding Traceable author statement Ref.1. Source: ProtInc extracellular matrix binding Inferred from electronic annotation. Source: Compara extracellular matrix structural constituent Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P98095-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P98095-2)

The sequence of this isoform differs from the canonical sequence as follows:
     718-718: E → EDQDECLMGAHDCSRRQFCVNTLGSFYCVNHTVLCADGYILNAHRKCV

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 27	27	Potential
	Chain	28 – 1184	1157	Fibulin-2		PRO_0000007568
Regions
	Domain	445 – 480	36	Anaphylatoxin-like 1
	Domain	488 – 519	32	Anaphylatoxin-like 2
	Domain	521 – 553	33	Anaphylatoxin-like 3
	Domain	604 – 645	42	EGF-like 1; calcium-binding
	Domain	679 – 718	40	EGF-like 2
	Domain	719 – 763	45	EGF-like 3; calcium-binding
	Domain	764 – 809	46	EGF-like 4; calcium-binding
	Domain	810 – 857	48	EGF-like 5; calcium-binding
	Domain	858 – 900	43	EGF-like 6; calcium-binding
	Domain	901 – 942	42	EGF-like 7; calcium-binding
	Domain	943 – 981	39	EGF-like 8; calcium-binding
	Domain	982 – 1024	43	EGF-like 9; calcium-binding
	Domain	1025 – 1069	45	EGF-like 10; calcium-binding
	Region	28 – 444	417	N
	Region	28 – 177	150	Subdomain NA (Cys-rich)
	Region	178 – 444	267	Subdomain NB (Cys-free)
	Region	1070 – 1184	115	Domain III
Amino acid modifications
	Modified residue	277	1	Phosphoserine Ref.6
	Glycosylation	180	1	N-linked (GlcNAc...) Potential
	Glycosylation	347	1	O-linked (GalNAc...); or Ser-348 Ref.8
	Glycosylation	348	1	O-linked (GalNAc...); or Thr-347 Ref.8
	Glycosylation	507	1	N-linked (GlcNAc...) Potential
	Glycosylation	1035	1	N-linked (GlcNAc...) Ref.7
	Disulfide bond	445 ↔ 472		By similarity
	Disulfide bond	446 ↔ 479		By similarity
	Disulfide bond	459 ↔ 480		By similarity
	Disulfide bond	489 ↔ 518		By similarity
	Disulfide bond	502 ↔ 519		By similarity
	Disulfide bond	521 ↔ 545		By similarity
	Disulfide bond	522 ↔ 552		By similarity
	Disulfide bond	535 ↔ 553		By similarity
	Disulfide bond	608 ↔ 620		By similarity
	Disulfide bond	616 ↔ 629		By similarity
	Disulfide bond	631 ↔ 644		By similarity
	Disulfide bond	683 ↔ 693		By similarity
	Disulfide bond	689 ↔ 702		By similarity
	Disulfide bond	704 ↔ 717		By similarity
	Disulfide bond	723 ↔ 736		By similarity
	Disulfide bond	730 ↔ 745		By similarity
	Disulfide bond	751 ↔ 762		By similarity
	Disulfide bond	768 ↔ 781		By similarity
	Disulfide bond	775 ↔ 790		By similarity
	Disulfide bond	796 ↔ 808		By similarity
	Disulfide bond	814 ↔ 827		By similarity
	Disulfide bond	821 ↔ 836		By similarity
	Disulfide bond	843 ↔ 856		By similarity
	Disulfide bond	862 ↔ 875		By similarity
	Disulfide bond	869 ↔ 884		By similarity
	Disulfide bond	886 ↔ 899		By similarity
	Disulfide bond	905 ↔ 917		By similarity
	Disulfide bond	913 ↔ 926		By similarity
	Disulfide bond	928 ↔ 941		By similarity
	Disulfide bond	947 ↔ 956		By similarity
	Disulfide bond	952 ↔ 965		By similarity
	Disulfide bond	967 ↔ 980		By similarity
	Disulfide bond	986 ↔ 998		By similarity
	Disulfide bond	994 ↔ 1007		By similarity
	Disulfide bond	1009 ↔ 1023		By similarity
	Disulfide bond	1029 ↔ 1042		By similarity
	Disulfide bond	1036 ↔ 1051		By similarity
	Disulfide bond	1056 ↔ 1068		By similarity
Natural variations
	Alternative sequence	718	1	E → EDQDECLMGAHDCSRRQFCV NTLGSFYCVNHTVLCADGYI LNAHRKCV in isoform 2.		VSP_041404
	Natural variant	45	1	I → V. Corresponds to variant rs60850813 [ dbSNP | Ensembl ].		VAR_061159
	Natural variant	144	1	H → R. Corresponds to variant rs28587534 [ dbSNP | Ensembl ].		VAR_061160
	Natural variant	361	1	S → G. Corresponds to variant rs3732666 [ dbSNP | Ensembl ].		VAR_059266
	Natural variant	387	1	N → T. Corresponds to variant rs3796318 [ dbSNP | Ensembl ].		VAR_059267
	Natural variant	854	1	T → A. Ref.1 Corresponds to variant rs9843344 [ dbSNP | Ensembl ].		VAR_059268
	Natural variant	1114	1	G → R. Corresponds to variant rs1061375 [ dbSNP | Ensembl ].		VAR_055722
Experimental info
	Sequence conflict	145	1	K → E in CAA57876. Ref.1
	Sequence conflict	145	1	K → E in AAN05436. Ref.2
	Sequence conflict	664	1	E → G in BAH14261. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 3, 2009. Version 2. Checksum: D46890D93518B343	FASTA	1,184	126,573
	10 20 30 40 50 60 MVLLWEPAGA WLALGLALAL GPSVAAAAPR QDCTGVECPP LENCIEEALE PGACCATCVQ 70 80 90 100 110 120 QGCACEGYQY YDCLQGGFVR GRVPAGQSYF VDFGSTECSC PPGGGKISCQ FMLCPELPPN 130 140 150 160 170 180 CIEAVVVADS CPQCGQVGCV HAGHKYAAGH TVHLPPCRAC HCPDAGGELI CYQLPGCHGN 190 200 210 220 230 240 FSDAEEGDPE RHYEDPYSYD QEVAEVEAAT ALGGEVQAGA VQAGAGGPPA ALGGGSQPLS 250 260 270 280 290 300 TIQAPPWPAV LPRPTAAAAL GPPAPVQAKA RRVTEDSEEE EEEEEEREEM AVTEQLAAGG 310 320 330 340 350 360 HRGLDGLPTT APAGPSLPIQ EERAEAGARA EAGARPEENL ILDAQATSRS TGPEGVTHAP 370 380 390 400 410 420 SLGKAALVPT QAVPGSPRDP VKPSPHNILS TSLPDAAWIP PTREVPRKPQ VLPHSHVEED 430 440 450 460 470 480 TDPNSVHSIP RSSPEGSTKD LIETCCAAGQ QWAIDNDECL EIPESGTEDN VCRTAQRHCC 490 500 510 520 530 540 VSYLQEKSCM AGVLGAKEGE TCGAEDNDSC GISLYKQCCD CCGLGLRVRA EGQSCESNPN 550 560 570 580 590 600 LGYPCNHVML SCCEGEEPLI VPEVRRPPEP AAAPRRVSEA EMAGREALSL GTEAELPNSL 610 620 630 640 650 660 PGDDQDECLL LPGELCQHLC INTVGSYHCA CFPGFSLQDD GRTCRPEGHP PQPEAPQEPA 670 680 690 700 710 720 LKSEFSQVAS NTIPLPLPQP NTCKDNGPCK QVCSTVGGSA ICSCFPGYAI MADGVSCEDI 730 740 750 760 770 780 NECVTDLHTC SRGEHCVNTL GSFHCYKALT CEPGYALKDG ECEDVDECAM GTHTCQPGFL 790 800 810 820 830 840 CQNTKGSFYC QARQRCMDGF LQDPEGNCVD INECTSLSEP CRPGFSCINT VGSYTCQRNP 850 860 870 880 890 900 LICARGYHAS DDGTKCVDVN ECETGVHRCG EGQVCHNLPG SYRCDCKAGF QRDAFGRGCI 910 920 930 940 950 960 DVNECWASPG RLCQHTCENT LGSYRCSCAS GFLLAADGKR CEDVNECEAQ RCSQECANIY 970 980 990 1000 1010 1020 GSYQCYCRQG YQLAEDGHTC TDIDECAQGA GILCTFRCLN VPGSYQCACP EQGYTMTANG 1030 1040 1050 1060 1070 1080 RSCKDVDECA LGTHNCSEAE TCHNIQGSFR CLRFECPPNY VQVSKTKCER TTCHDFLECQ 1090 1100 1110 1120 1130 1140 NSPARITHYQ LNFQTGLLVP AHIFRIGPAP AFTGDTIALN IIKGNEEGYF GTRRLNAYTG 1150 1160 1170 1180 VVYLQRAVLE PRDFALDVEM KLWRQGSVTT FLAKMHIFFT TFAL
	Isoform 2 [UniParc]. Checksum: 914C7630E2D9FC4E	FASTA	1,231	131,863
	10 20 30 40 50 60 MVLLWEPAGA WLALGLALAL GPSVAAAAPR QDCTGVECPP LENCIEEALE PGACCATCVQ 70 80 90 100 110 120 QGCACEGYQY YDCLQGGFVR GRVPAGQSYF VDFGSTECSC PPGGGKISCQ FMLCPELPPN 130 140 150 160 170 180 CIEAVVVADS CPQCGQVGCV HAGHKYAAGH TVHLPPCRAC HCPDAGGELI CYQLPGCHGN 190 200 210 220 230 240 FSDAEEGDPE RHYEDPYSYD QEVAEVEAAT ALGGEVQAGA VQAGAGGPPA ALGGGSQPLS 250 260 270 280 290 300 TIQAPPWPAV LPRPTAAAAL GPPAPVQAKA RRVTEDSEEE EEEEEEREEM AVTEQLAAGG 310 320 330 340 350 360 HRGLDGLPTT APAGPSLPIQ EERAEAGARA EAGARPEENL ILDAQATSRS TGPEGVTHAP 370 380 390 400 410 420 SLGKAALVPT QAVPGSPRDP VKPSPHNILS TSLPDAAWIP PTREVPRKPQ VLPHSHVEED 430 440 450 460 470 480 TDPNSVHSIP RSSPEGSTKD LIETCCAAGQ QWAIDNDECL EIPESGTEDN VCRTAQRHCC 490 500 510 520 530 540 VSYLQEKSCM AGVLGAKEGE TCGAEDNDSC GISLYKQCCD CCGLGLRVRA EGQSCESNPN 550 560 570 580 590 600 LGYPCNHVML SCCEGEEPLI VPEVRRPPEP AAAPRRVSEA EMAGREALSL GTEAELPNSL 610 620 630 640 650 660 PGDDQDECLL LPGELCQHLC INTVGSYHCA CFPGFSLQDD GRTCRPEGHP PQPEAPQEPA 670 680 690 700 710 720 LKSEFSQVAS NTIPLPLPQP NTCKDNGPCK QVCSTVGGSA ICSCFPGYAI MADGVSCEDQ 730 740 750 760 770 780 DECLMGAHDC SRRQFCVNTL GSFYCVNHTV LCADGYILNA HRKCVDINEC VTDLHTCSRG 790 800 810 820 830 840 EHCVNTLGSF HCYKALTCEP GYALKDGECE DVDECAMGTH TCQPGFLCQN TKGSFYCQAR 850 860 870 880 890 900 QRCMDGFLQD PEGNCVDINE CTSLSEPCRP GFSCINTVGS YTCQRNPLIC ARGYHASDDG 910 920 930 940 950 960 TKCVDVNECE TGVHRCGEGQ VCHNLPGSYR CDCKAGFQRD AFGRGCIDVN ECWASPGRLC 970 980 990 1000 1010 1020 QHTCENTLGS YRCSCASGFL LAADGKRCED VNECEAQRCS QECANIYGSY QCYCRQGYQL 1030 1040 1050 1060 1070 1080 AEDGHTCTDI DECAQGAGIL CTFRCLNVPG SYQCACPEQG YTMTANGRSC KDVDECALGT 1090 1100 1110 1120 1130 1140 HNCSEAETCH NIQGSFRCLR FECPPNYVQV SKTKCERTTC HDFLECQNSP ARITHYQLNF 1150 1160 1170 1180 1190 1200 QTGLLVPAHI FRIGPAPAFT GDTIALNIIK GNEEGYFGTR RLNAYTGVVY LQRAVLEPRD 1210 1220 1230 FALDVEMKLW RQGSVTTFLA KMHIFFTTFA L

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Fibulin-2 (FBLN2): human cDNA sequence, mRNA expression, and mapping of the gene on human and mouse chromosomes." Zhang R.-Z., Pan T.-C., Zhang Z.-Y., Mattei M.-G., Timpl R., Chu M.-L. Genomics 22:425-430(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ALA-854. Tissue: Fibroblast.
[2]	"Identification of a novel alternatively spliced isoform of human fibulin-2 gene abundantly expressed in heart and genetic evaluation in patients with ARVD." Li D., Marian A.J., Roberts R. Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 2), ALTERNATIVE SPLICING.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Uterus.
[4]	"The DNA sequence, annotation and analysis of human chromosome 3." Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A. Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The extracellular matrix proteins fibulin-1 and fibulin-2 in the early human embryo." Miosge N., Gotz W., Sasaki T., Chu M.-L., Timpl R., Herken R. Histochem. J. 28:109-116(1996) [PubMed] [Europe PMC] [Abstract] Cited for: DEVELOPMENTAL STAGE.
[6]	"Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography." Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D., Zou H., Gu J. Proteomics 8:1346-1361(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-277, MASS SPECTROMETRY. Tissue: Liver.
[7]	"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry." Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H. J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-1035, MASS SPECTROMETRY. Tissue: Liver.
[8]	"Human urinary glycoproteomics; attachment site specific analysis of N-and O-linked glycosylations by CID and ECD." Halim A., Nilsson J., Ruetschi U., Hesse C., Larson G. Mol. Cell. Proteomics 0:0-0(2011) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION AT THR-347 AND SER-348, STRUCTURE OF CARBOHYDRATES, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X82494 mRNA. Translation: CAA57876.1. AY130458, AY130456, AY130457 Genomic DNA. Translation: AAN05435.1. AY130459 mRNA. Translation: AAN05436.1. AK304827 mRNA. Translation: BAH14261.1. AC090509 Genomic DNA. No translation available.
IPI	IPI00465038. IPI01010639.
PIR	A55184.
RefSeq	NP_001004019.1. NM_001004019.1. NP_001158507.1. NM_001165035.1. NP_001989.2. NM_001998.2.
UniGene	Hs.198862.
3D structure databases
ProteinModelPortal	P98095.
ModBase	Search...
Protein-protein interaction databases
IntAct	P98095. 4 interactions.
MINT	MINT-1518617.
STRING	9606.ENSP00000384169.
PTM databases
PhosphoSite	P98095.
Polymorphism databases
DMDM	224471827.
Proteomic databases
PaxDb	P98095.
PRIDE	P98095.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000295760; ENSP00000295760; ENSG00000163520. ENST00000404922; ENSP00000384169; ENSG00000163520. ENST00000492059; ENSP00000420042; ENSG00000163520.
GeneID	2199.
KEGG	hsa:2199.
UCSC	uc011ava.2. human. uc011avb.2. human.
Organism-specific databases
CTD	2199.
GeneCards	GC03P013565.
H-InvDB	HIX0003076.
HGNC	HGNC:3601. FBLN2.
HPA	CAB018622. HPA001934.
MIM	135821. gene.
neXtProt	NX_P98095.
PharmGKB	PA28014.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG12793.
HOGENOM	HOG000007079.
HOVERGEN	HBG051559.
OMA	HSVPRGD.
Enzyme and pathway databases
Reactome	REACT_118779. Extracellular matrix organization.
Gene expression databases
ArrayExpress	P98095.
Bgee	P98095.
CleanEx	HS_FBLN2.
Genevestigator	P98095.
GermOnline	ENSG00000163520. Homo sapiens.
Family and domain databases
InterPro	IPR000020. Anaphylatoxin/fibulin. IPR026823. cEGF. IPR000742. EG-like_dom. IPR001881. EGF-like_Ca-bd. IPR013032. EGF-like_CS. IPR000152. EGF-type_Asp/Asn_hydroxyl_site. IPR018097. EGF_Ca-bd_CS. [Graphical view]
Pfam	PF01821. ANATO. 2 hits. PF12662. cEGF. 2 hits. PF07645. EGF_CA. 6 hits. [Graphical view]
SMART	SM00104. ANATO. 3 hits. SM00181. EGF. 1 hit. SM00179. EGF_CA. 9 hits. [Graphical view]
PROSITE	PS01177. ANAPHYLATOXIN_1. 3 hits. PS01178. ANAPHYLATOXIN_2. 3 hits. PS00010. ASX_HYDROXYL. 5 hits. PS00022. EGF_1. False negative. PS01186. EGF_2. 5 hits. PS50026. EGF_3. 4 hits. PS01187. EGF_CA. 9 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	2199.
NextBio	8885.
SOURCE	Search...

Entry information

Entry name

FBLN2_HUMAN

Accession

Primary (citable) accession number: P98095
Secondary accession number(s): B7Z9C5, Q8IUI0, Q8IUI1

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	March 3, 2009
Last modified:	May 1, 2013
This is version 124 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.