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P98095

- FBLN2_HUMAN

UniProt

P98095 - FBLN2_HUMAN

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Protein

Fibulin-2

Gene
FBLN2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Its binding to fibronectin and some other ligands is calcium dependent.

GO - Molecular functioni

  1. calcium ion binding Source: ProtInc
  2. extracellular matrix binding Source: Ensembl
  3. extracellular matrix structural constituent Source: ProtInc

GO - Biological processi

  1. extracellular matrix organization Source: Reactome
  2. positive regulation of cell-substrate adhesion Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

Calcium

Enzyme and pathway databases

ReactomeiREACT_150331. Molecules associated with elastic fibres.

Names & Taxonomyi

Protein namesi
Recommended name:
Fibulin-2
Short name:
FIBL-2
Gene namesi
Name:FBLN2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:3601. FBLN2.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: Reactome
  2. extracellular vesicular exosome Source: UniProt
  3. proteinaceous extracellular matrix Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28014.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727 Reviewed predictionAdd
BLAST
Chaini28 – 11841157Fibulin-2PRO_0000007568Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi180 – 1801N-linked (GlcNAc...) Reviewed prediction
Modified residuei277 – 2771Phosphoserine1 Publication
Glycosylationi347 – 3471O-linked (GalNAc...); or Ser-3481 Publication
Glycosylationi348 – 3481O-linked (GalNAc...); or Thr-3471 Publication
Disulfide bondi445 ↔ 472 By similarity
Disulfide bondi446 ↔ 479 By similarity
Disulfide bondi459 ↔ 480 By similarity
Disulfide bondi489 ↔ 518 By similarity
Disulfide bondi502 ↔ 519 By similarity
Glycosylationi507 – 5071N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi521 ↔ 545 By similarity
Disulfide bondi522 ↔ 552 By similarity
Disulfide bondi535 ↔ 553 By similarity
Disulfide bondi608 ↔ 620 By similarity
Disulfide bondi616 ↔ 629 By similarity
Disulfide bondi631 ↔ 644 By similarity
Disulfide bondi683 ↔ 693 By similarity
Disulfide bondi689 ↔ 702 By similarity
Disulfide bondi704 ↔ 717 By similarity
Disulfide bondi723 ↔ 736 By similarity
Disulfide bondi730 ↔ 745 By similarity
Disulfide bondi751 ↔ 762 By similarity
Disulfide bondi768 ↔ 781 By similarity
Disulfide bondi775 ↔ 790 By similarity
Disulfide bondi796 ↔ 808 By similarity
Disulfide bondi814 ↔ 827 By similarity
Disulfide bondi821 ↔ 836 By similarity
Disulfide bondi843 ↔ 856 By similarity
Disulfide bondi862 ↔ 875 By similarity
Disulfide bondi869 ↔ 884 By similarity
Disulfide bondi886 ↔ 899 By similarity
Disulfide bondi905 ↔ 917 By similarity
Disulfide bondi913 ↔ 926 By similarity
Disulfide bondi928 ↔ 941 By similarity
Disulfide bondi947 ↔ 956 By similarity
Disulfide bondi952 ↔ 965 By similarity
Disulfide bondi967 ↔ 980 By similarity
Disulfide bondi986 ↔ 998 By similarity
Disulfide bondi994 ↔ 1007 By similarity
Disulfide bondi1009 ↔ 1023 By similarity
Disulfide bondi1029 ↔ 1042 By similarity
Glycosylationi1035 – 10351N-linked (GlcNAc...)1 Publication
Disulfide bondi1036 ↔ 1051 By similarity
Disulfide bondi1056 ↔ 1068 By similarity

Post-translational modificationi

O-glycosylated with core 1 or possibly core 8 glycans. It is unsure if the O-glycosylation is on Thr-347 or Ser-348.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP98095.
PaxDbiP98095.
PRIDEiP98095.

PTM databases

PhosphoSiteiP98095.

Expressioni

Tissue specificityi

Component of both basement membranes and other connective tissues. Expressed in heart, placenta and ovary.

Developmental stagei

Widely expressed during embryonic development. Primarily detected within the neuropithelium, spinal ganglia and peripheral nerves.1 Publication

Gene expression databases

ArrayExpressiP98095.
BgeeiP98095.
CleanExiHS_FBLN2.
GenevestigatoriP98095.

Organism-specific databases

HPAiCAB018622.
HPA001934.

Interactioni

Subunit structurei

Homotrimer; disulfide-linked. Interacts with LAMA2 By similarity.

Protein-protein interaction databases

BioGridi108493. 15 interactions.
IntActiP98095. 5 interactions.
MINTiMINT-1518617.
STRINGi9606.ENSP00000384169.

Structurei

3D structure databases

ProteinModelPortaliP98095.
SMRiP98095. Positions 604-637, 685-1060.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini445 – 48036Anaphylatoxin-like 1Add
BLAST
Domaini488 – 51932Anaphylatoxin-like 2Add
BLAST
Domaini521 – 55333Anaphylatoxin-like 3Add
BLAST
Domaini604 – 64542EGF-like 1; calcium-bindingAdd
BLAST
Domaini679 – 71840EGF-like 2Add
BLAST
Domaini719 – 76345EGF-like 3; calcium-bindingAdd
BLAST
Domaini764 – 80946EGF-like 4; calcium-bindingAdd
BLAST
Domaini810 – 85748EGF-like 5; calcium-bindingAdd
BLAST
Domaini858 – 90043EGF-like 6; calcium-bindingAdd
BLAST
Domaini901 – 94242EGF-like 7; calcium-bindingAdd
BLAST
Domaini943 – 98139EGF-like 8; calcium-bindingAdd
BLAST
Domaini982 – 102443EGF-like 9; calcium-bindingAdd
BLAST
Domaini1025 – 106945EGF-like 10; calcium-bindingAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni28 – 444417NAdd
BLAST
Regioni28 – 177150Subdomain NA (Cys-rich)Add
BLAST
Regioni178 – 444267Subdomain NB (Cys-free)Add
BLAST
Regioni1070 – 1184115Domain IIIAdd
BLAST

Sequence similaritiesi

Belongs to the fibulin family.
Contains 10 EGF-like domains.

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiNOG12793.
HOGENOMiHOG000007079.
HOVERGENiHBG051559.
KOiK17307.
OMAiSETKCER.
OrthoDBiEOG7P5T0C.
PhylomeDBiP98095.
TreeFamiTF317514.

Family and domain databases

InterProiIPR000020. Anaphylatoxin/fibulin.
IPR026823. cEGF.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_N_dom.
[Graphical view]
PfamiPF01821. ANATO. 2 hits.
PF12662. cEGF. 2 hits.
PF07645. EGF_CA. 5 hits.
[Graphical view]
SMARTiSM00104. ANATO. 3 hits.
SM00181. EGF. 1 hit.
SM00179. EGF_CA. 9 hits.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 5 hits.
PROSITEiPS01177. ANAPHYLATOXIN_1. 3 hits.
PS01178. ANAPHYLATOXIN_2. 3 hits.
PS00010. ASX_HYDROXYL. 5 hits.
PS01186. EGF_2. 5 hits.
PS50026. EGF_3. 4 hits.
PS01187. EGF_CA. 9 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P98095-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MVLLWEPAGA WLALGLALAL GPSVAAAAPR QDCTGVECPP LENCIEEALE     50
PGACCATCVQ QGCACEGYQY YDCLQGGFVR GRVPAGQSYF VDFGSTECSC 100
PPGGGKISCQ FMLCPELPPN CIEAVVVADS CPQCGQVGCV HAGHKYAAGH 150
TVHLPPCRAC HCPDAGGELI CYQLPGCHGN FSDAEEGDPE RHYEDPYSYD 200
QEVAEVEAAT ALGGEVQAGA VQAGAGGPPA ALGGGSQPLS TIQAPPWPAV 250
LPRPTAAAAL GPPAPVQAKA RRVTEDSEEE EEEEEEREEM AVTEQLAAGG 300
HRGLDGLPTT APAGPSLPIQ EERAEAGARA EAGARPEENL ILDAQATSRS 350
TGPEGVTHAP SLGKAALVPT QAVPGSPRDP VKPSPHNILS TSLPDAAWIP 400
PTREVPRKPQ VLPHSHVEED TDPNSVHSIP RSSPEGSTKD LIETCCAAGQ 450
QWAIDNDECL EIPESGTEDN VCRTAQRHCC VSYLQEKSCM AGVLGAKEGE 500
TCGAEDNDSC GISLYKQCCD CCGLGLRVRA EGQSCESNPN LGYPCNHVML 550
SCCEGEEPLI VPEVRRPPEP AAAPRRVSEA EMAGREALSL GTEAELPNSL 600
PGDDQDECLL LPGELCQHLC INTVGSYHCA CFPGFSLQDD GRTCRPEGHP 650
PQPEAPQEPA LKSEFSQVAS NTIPLPLPQP NTCKDNGPCK QVCSTVGGSA 700
ICSCFPGYAI MADGVSCEDI NECVTDLHTC SRGEHCVNTL GSFHCYKALT 750
CEPGYALKDG ECEDVDECAM GTHTCQPGFL CQNTKGSFYC QARQRCMDGF 800
LQDPEGNCVD INECTSLSEP CRPGFSCINT VGSYTCQRNP LICARGYHAS 850
DDGTKCVDVN ECETGVHRCG EGQVCHNLPG SYRCDCKAGF QRDAFGRGCI 900
DVNECWASPG RLCQHTCENT LGSYRCSCAS GFLLAADGKR CEDVNECEAQ 950
RCSQECANIY GSYQCYCRQG YQLAEDGHTC TDIDECAQGA GILCTFRCLN 1000
VPGSYQCACP EQGYTMTANG RSCKDVDECA LGTHNCSEAE TCHNIQGSFR 1050
CLRFECPPNY VQVSKTKCER TTCHDFLECQ NSPARITHYQ LNFQTGLLVP 1100
AHIFRIGPAP AFTGDTIALN IIKGNEEGYF GTRRLNAYTG VVYLQRAVLE 1150
PRDFALDVEM KLWRQGSVTT FLAKMHIFFT TFAL 1184
Length:1,184
Mass (Da):126,573
Last modified:March 3, 2009 - v2
Checksum:iD46890D93518B343
GO
Isoform 2 (identifier: P98095-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     718-718: E → EDQDECLMGAHDCSRRQFCVNTLGSFYCVNHTVLCADGYILNAHRKCV

Show »
Length:1,231
Mass (Da):131,863
Checksum:i914C7630E2D9FC4E
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti45 – 451I → V.
Corresponds to variant rs60850813 [ dbSNP | Ensembl ].
VAR_061159
Natural varianti144 – 1441H → R.
Corresponds to variant rs28587534 [ dbSNP | Ensembl ].
VAR_061160
Natural varianti361 – 3611S → G.
Corresponds to variant rs3732666 [ dbSNP | Ensembl ].
VAR_059266
Natural varianti387 – 3871N → T.
Corresponds to variant rs3796318 [ dbSNP | Ensembl ].
VAR_059267
Natural varianti854 – 8541T → A.1 Publication
Corresponds to variant rs9843344 [ dbSNP | Ensembl ].
VAR_059268
Natural varianti1114 – 11141G → R.
Corresponds to variant rs1061375 [ dbSNP | Ensembl ].
VAR_055722

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei718 – 7181E → EDQDECLMGAHDCSRRQFCV NTLGSFYCVNHTVLCADGYI LNAHRKCV in isoform 2. VSP_041404

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti145 – 1451K → E in CAA57876. 1 Publication
Sequence conflicti145 – 1451K → E in AAN05436. 1 Publication
Sequence conflicti664 – 6641E → G in BAH14261. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X82494 mRNA. Translation: CAA57876.1.
AY130458, AY130456, AY130457 Genomic DNA. Translation: AAN05435.1.
AY130459 mRNA. Translation: AAN05436.1.
AK304827 mRNA. Translation: BAH14261.1.
AC090509 Genomic DNA. No translation available.
CCDSiCCDS46761.1. [P98095-2]
CCDS46762.1. [P98095-1]
PIRiA55184.
RefSeqiNP_001004019.1. NM_001004019.1. [P98095-2]
NP_001158507.1. NM_001165035.1. [P98095-2]
NP_001989.2. NM_001998.2. [P98095-1]
UniGeneiHs.198862.

Genome annotation databases

EnsembliENST00000295760; ENSP00000295760; ENSG00000163520. [P98095-1]
ENST00000404922; ENSP00000384169; ENSG00000163520. [P98095-2]
ENST00000492059; ENSP00000420042; ENSG00000163520. [P98095-2]
GeneIDi2199.
KEGGihsa:2199.
UCSCiuc011ava.2. human. [P98095-2]
uc011avb.2. human. [P98095-1]

Polymorphism databases

DMDMi224471827.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X82494 mRNA. Translation: CAA57876.1 .
AY130458 , AY130456 , AY130457 Genomic DNA. Translation: AAN05435.1 .
AY130459 mRNA. Translation: AAN05436.1 .
AK304827 mRNA. Translation: BAH14261.1 .
AC090509 Genomic DNA. No translation available.
CCDSi CCDS46761.1. [P98095-2 ]
CCDS46762.1. [P98095-1 ]
PIRi A55184.
RefSeqi NP_001004019.1. NM_001004019.1. [P98095-2 ]
NP_001158507.1. NM_001165035.1. [P98095-2 ]
NP_001989.2. NM_001998.2. [P98095-1 ]
UniGenei Hs.198862.

3D structure databases

ProteinModelPortali P98095.
SMRi P98095. Positions 604-637, 685-1060.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 108493. 15 interactions.
IntActi P98095. 5 interactions.
MINTi MINT-1518617.
STRINGi 9606.ENSP00000384169.

PTM databases

PhosphoSitei P98095.

Polymorphism databases

DMDMi 224471827.

Proteomic databases

MaxQBi P98095.
PaxDbi P98095.
PRIDEi P98095.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000295760 ; ENSP00000295760 ; ENSG00000163520 . [P98095-1 ]
ENST00000404922 ; ENSP00000384169 ; ENSG00000163520 . [P98095-2 ]
ENST00000492059 ; ENSP00000420042 ; ENSG00000163520 . [P98095-2 ]
GeneIDi 2199.
KEGGi hsa:2199.
UCSCi uc011ava.2. human. [P98095-2 ]
uc011avb.2. human. [P98095-1 ]

Organism-specific databases

CTDi 2199.
GeneCardsi GC03P013565.
H-InvDB HIX0003076.
HGNCi HGNC:3601. FBLN2.
HPAi CAB018622.
HPA001934.
MIMi 135821. gene.
neXtProti NX_P98095.
PharmGKBi PA28014.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG12793.
HOGENOMi HOG000007079.
HOVERGENi HBG051559.
KOi K17307.
OMAi SETKCER.
OrthoDBi EOG7P5T0C.
PhylomeDBi P98095.
TreeFami TF317514.

Enzyme and pathway databases

Reactomei REACT_150331. Molecules associated with elastic fibres.

Miscellaneous databases

GeneWikii FBLN2.
GenomeRNAii 2199.
NextBioi 8885.
PROi P98095.
SOURCEi Search...

Gene expression databases

ArrayExpressi P98095.
Bgeei P98095.
CleanExi HS_FBLN2.
Genevestigatori P98095.

Family and domain databases

InterProi IPR000020. Anaphylatoxin/fibulin.
IPR026823. cEGF.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_N_dom.
[Graphical view ]
Pfami PF01821. ANATO. 2 hits.
PF12662. cEGF. 2 hits.
PF07645. EGF_CA. 5 hits.
[Graphical view ]
SMARTi SM00104. ANATO. 3 hits.
SM00181. EGF. 1 hit.
SM00179. EGF_CA. 9 hits.
[Graphical view ]
SUPFAMi SSF57184. SSF57184. 5 hits.
PROSITEi PS01177. ANAPHYLATOXIN_1. 3 hits.
PS01178. ANAPHYLATOXIN_2. 3 hits.
PS00010. ASX_HYDROXYL. 5 hits.
PS01186. EGF_2. 5 hits.
PS50026. EGF_3. 4 hits.
PS01187. EGF_CA. 9 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Fibulin-2 (FBLN2): human cDNA sequence, mRNA expression, and mapping of the gene on human and mouse chromosomes."
    Zhang R.-Z., Pan T.-C., Zhang Z.-Y., Mattei M.-G., Timpl R., Chu M.-L.
    Genomics 22:425-430(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ALA-854.
    Tissue: Fibroblast.
  2. "Identification of a novel alternatively spliced isoform of human fibulin-2 gene abundantly expressed in heart and genetic evaluation in patients with ARVD."
    Li D., Marian A.J., Roberts R.
    Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 2), ALTERNATIVE SPLICING.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Uterus.
  4. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The extracellular matrix proteins fibulin-1 and fibulin-2 in the early human embryo."
    Miosge N., Gotz W., Sasaki T., Chu M.-L., Timpl R., Herken R.
    Histochem. J. 28:109-116(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: DEVELOPMENTAL STAGE.
  6. "Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography."
    Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D., Zou H., Gu J.
    Proteomics 8:1346-1361(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-277, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  7. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-1035.
    Tissue: Liver.
  8. "Human urinary glycoproteomics; attachment site specific analysis of N-and O-linked glycosylations by CID and ECD."
    Halim A., Nilsson J., Ruetschi U., Hesse C., Larson G.
    Mol. Cell. Proteomics 0:0-0(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION AT THR-347 AND SER-348, STRUCTURE OF CARBOHYDRATES, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiFBLN2_HUMAN
AccessioniPrimary (citable) accession number: P98095
Secondary accession number(s): B7Z9C5, Q8IUI0, Q8IUI1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: March 3, 2009
Last modified: September 3, 2014
This is version 137 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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