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P98092 (HMCT_BOMMO) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hemocytin
Alternative name(s):
Humoral lectin
OrganismBombyx mori (Silk moth) [Reference proteome]
Taxonomic identifier7091 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Lepidoptera › Glossata › Ditrysia › Bombycoidea › Bombycidae › Bombycinae › Bombyx

Protein attributes

Sequence length3133 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Adhesive protein and relates to hemostasis or encapsulation of foreign substances for self-defense.

Developmental stage

Expressed in hemocytes during larval-pupal metamorphosis.

Induction

Hemagglutination activity is increased by bacterial or viral infection and inhibited by D-mannose, N-acetyl-D-galactosamine and D-maltose.

Post-translational modification

May be converted into the 260 kDa mature hemocytin by proteolysis.

Sequence similarities

Contains 1 CTCK (C-terminal cystine knot-like) domain.

Contains 2 F5/8 type C domains.

Contains 6 TIL (trypsin inhibitory-like) domains.

Contains 2 VWFC domains.

Contains 3 VWFD domains.

Ontologies

Keywords
   Biological processCell adhesion
   DomainRepeat
Signal
   LigandLectin
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell adhesion

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionnucleic acid binding

Inferred from electronic annotation. Source: InterPro

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – ? Potential
Chain? – 3133HemocytinPRO_0000021445

Regions

Domain40 – 9657TIL 1
Domain153 – 20957TIL 2
Domain248 – 455208VWFD 1
Domain509 – 57668TIL 3
Domain770 – 83768TIL 4
Domain940 – 1095156F5/8 type C 1
Domain1116 – 1254139F5/8 type C 2
Domain1619 – 1824206VWFD 2
Domain1890 – 194859TIL 5
Domain1953 – 2179227VWFD 3
Domain2229 – 228557TIL 6
Domain2553 – 262270VWFC 1
Domain2842 – 290766VWFC 2
Domain2971 – 3076106CTCK
Compositional bias895 – 91420Poly-Thr
Compositional bias1267 – 12704Poly-Glu
Compositional bias1425 – 14284Poly-Thr
Compositional bias1447 – 14504Poly-Thr
Compositional bias1474 – 14796Poly-Ser
Compositional bias2148 – 21536Poly-Pro
Compositional bias2156 – 21594Poly-Pro
Compositional bias2341 – 23444Poly-Pro

Amino acid modifications

Glycosylation1511N-linked (GlcNAc...) Potential
Glycosylation2371N-linked (GlcNAc...) Potential
Glycosylation5641N-linked (GlcNAc...) Potential
Glycosylation11701N-linked (GlcNAc...) Potential
Glycosylation13871N-linked (GlcNAc...) Potential
Glycosylation16221N-linked (GlcNAc...) Potential
Glycosylation17271N-linked (GlcNAc...) Potential
Glycosylation18471N-linked (GlcNAc...) Potential
Glycosylation19751N-linked (GlcNAc...) Potential
Glycosylation19851N-linked (GlcNAc...) Potential
Glycosylation20931N-linked (GlcNAc...) Potential
Glycosylation21131N-linked (GlcNAc...) Potential
Glycosylation21611N-linked (GlcNAc...) Potential
Glycosylation22761N-linked (GlcNAc...) Potential
Glycosylation24511N-linked (GlcNAc...) Potential
Glycosylation26471N-linked (GlcNAc...) Potential
Glycosylation26541N-linked (GlcNAc...) Potential
Glycosylation26631N-linked (GlcNAc...) Potential
Glycosylation27941N-linked (GlcNAc...) Potential
Glycosylation28101N-linked (GlcNAc...) Potential
Glycosylation28651N-linked (GlcNAc...) Potential
Glycosylation29291N-linked (GlcNAc...) Potential
Glycosylation29641N-linked (GlcNAc...) Potential
Glycosylation30281N-linked (GlcNAc...) Potential
Disulfide bond940 ↔ 1095 By similarity
Disulfide bond1116 ↔ 1254 By similarity
Disulfide bond2971 ↔ 3040 By similarity
Disulfide bond2991 ↔ 3054 By similarity
Disulfide bond3004 ↔ 3070 By similarity
Disulfide bond3020 ↔ 3072 By similarity
Disulfide bond? ↔ 3075 By similarity

Natural variations

Natural variant12881R → G.
Natural variant13051T → S.

Sequences

Sequence LengthMass (Da)Tools
P98092 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: E5210D5D14A7B2B2

FASTA3,133343,355
        10         20         30         40         50         60 
MRGGRDPVPV PVLGDYAMVC AKNGIILQWR YNVKECELSC TGGQQYTVCA DSCLRKCSDT 

        70         80         90        100        110        120 
ALAASGQCKP VCVEGCACSP SQLLDDNGVC VPVAKCPCIH KGLQFNAGYK EIRPGRRERE 

       130        140        150        160        170        180 
LCTCVGARWD CKPATPEEIQ NYPPAEDLRS NSTAQNMEFT TCETSEPLTC KNMHLPPSTQ 

       190        200        210        220        230        240 
TAECRPGCQC KKGQVLDTAS KRCVPATQCP CHHAGRSYPD GHLMQEECNK CECKNGNWSC 

       250        260        270        280        290        300 
TQRKCAGVCG AWGDSHVNTF DGTQYDFEGV CTYLLAKGAM DGTDGFDVEI QNVPCGTTGA 

       310        320        330        340        350        360 
TCSKSVTLKV GGAGNEEIVS LTKNAPIPDI SKLKRIKMRK AGAYVFLDVP SLGMSLQWDR 

       370        380        390        400        410        420 
GLRVYVKIDT MWQGRVKGLC GNYNGDMRDD FQTPSGGGMS ESSALIFADS WKLKPTCPKP 

       430        440        450        460        470        480 
QPVIDHCKQR PERKEWAQSV CGALKRYPFS LCAGEVGAGA YVARCERDAC DAGADCECAC 

       490        500        510        520        530        540 
AALAAYAHAC AHRGVTFNWR TNDLCPMQCD EVCSNYDSCV SACPVETCDN ILYYAETTAR 

       550        560        570        580        590        600 
CEQDTCVEGC KPKKSCPEGS VYKNDSTTEC VPRAKCKPVC MTLDGGREVL EGEIIEEDAC 

       610        620        630        640        650        660 
HTCRCSKKHK VCTGQPCSTE APRIQATSSS AEPATERPHE PLKCVTGWTP WINRGPAEIG 

       670        680        690        700        710        720 
PDGQSVESEP LPKPNELQIG KPMCKPEMMK KIECRTVNDH KTPKETGLNV ECSLENGLVC 

       730        740        750        760        770        780 
EEPEKTCPDF EIKVYCECEE PQDTSPPVTV TSEASSEPVS TTLATTTSRC PPGEVYQACA 

       790        800        810        820        830        840 
YKCDRLCDHF KKTLIAKGRC ISEMCVDGCV DESVASNGCE GSSRWRDERT CVPVKDCTCY 

       850        860        870        880        890        900 
NDGQIVKPGG VTESGCIKCQ CLDNSLYCDS KDCVSLNIPH QGSTHLPYIV RPVSTTITST 

       910        920        930        940        950        960 
TTTTTTSTTT TTTTPEPTET TTETTVPLII KSTVSPPPEC SPDNYIDLVM GDEPLPDTAF 

       970        980        990       1000       1010       1020 
SASSEFSEIF APHNARLNRG PTNSGAGSWN PKVNNDKQYI QVELPRREPI YGVVLQGSPI 

      1030       1040       1050       1060       1070       1080 
FDQYVTSYEI MYGDDGNTFS TVDGPDGKPK IFRGPIDNTH PVKQMISPPI EAKVVRIRPL 

      1090       1100       1110       1120       1130       1140 
TWHDEISLRL EIIGCAEPLT TETSEPSPTS ESPLQCTEPL GLIGELPLEN IQVSSNSEEK 

      1150       1160       1170       1180       1190       1200 
DYLSINGNRG WKPLYNTPGW VMFDFTGPRN ITGILTKGGN DGWVTSYKVL YTSDFETFNP 

      1210       1220       1230       1240       1250       1260 
VIDKDGKEKI FPANFDGIVS VTNEFHPPIR ARYLKVLPQK WNKNIELRIE PIGCFEPYPE 

      1270       1280       1290       1300       1310       1320 
ILRSLPEEEE GREEPQVVRK EYGMSQEREM PNCHICPGVE AKECTCSYPE YFDGENCVPR 

      1330       1340       1350       1360       1370       1380 
AECPCVESFM TYPVGSTFRG ANCDECVCKL GGTTECKPFK ECQCDDESLV PKLSPTTCDC 

      1390       1400       1410       1420       1430       1440 
TCEPCTNGTK ICKTSKLCLA LESWCDGVQD CPDDERDCTT STARTTTTEP TVVTTVAPTQ 

      1450       1460       1470       1480       1490       1500 
AATAPPTTTT PKPVVECPKV ECPPGYIISY TTGSSSSYSR AFSSDLPPPR PRYSYQRYYR 

      1510       1520       1530       1540       1550       1560 
GRSTGGYSGY AKTGYSKGGF SKGGFSKGGY GYPSIPRSNQ AFTLDKPALT NKQPTSKEEC 

      1570       1580       1590       1600       1610       1620 
AQFKCISKLP AFKPGVVPPP VACSVVTCPA GYTLKLDKVP TGYNKCPQYE CVPPLERPVF 

      1630       1640       1650       1660       1670       1680 
CNMTGRTFNT FDGMEYKYDV CFHMLARDNK FDAWLIIVRK NCRLDGCTNE LIVMQDDQLI 

      1690       1700       1710       1720       1730       1740 
QVKPNMMVTY NNYEYTIEQT KKICFQKNSF DVDRLGNGIS ITSRKYNFTV LFNKEGDVKI 

      1750       1760       1770       1780       1790       1800 
GVLKKHMGGV DGLCGAYDGS LANERRLPDG RVATSIDEFG RSWAKPGVPA DACAPRVASA 

      1810       1820       1830       1840       1850       1860 
HKQRRAWDLC NVIAEEPFSQ CGKVLNLDKW RHICLEKICE CTDLVVNGTK RTEEQCRCLV 

      1870       1880       1890       1900       1910       1920 
LQQMAAECLA ADAGVDLASW RLMMDCPADC PPPLVHYDCY RKRCEETCAP YPNAARACPA 

      1930       1940       1950       1960       1970       1980 
QEGQCSPGCY CPDGKLRKGD QCVLPADCLD CTCTGVGTPA KYTTFEGDDL PFLGNCTYLA 

      1990       2000       2010       2020       2030       2040 
SRDRNQTGEH KYQVYATNGP CDDNANIVCT KIVHLIYEKN VIHISKDPTT KKLRTVIGKT 

      2050       2060       2070       2080       2090       2100 
AVFKYPVKEN WGTISLLNGQ DVSVTLPDIH VELTVSQLNL EFAVRVPTFL YGNRTEGLCG 

      2110       2120       2130       2140       2150       2160 
VCAGYQDFLV TSNGTVTDDF DLYGKSWQAS PEKLTELEVP SDEQCDAPPP PAPCTPPPPD 

      2170       2180       2190       2200       2210       2220 
NNTCYHLYNA DRFGACHALV EPQPYVESCE ADECGGHGPC DALQRYAAAC AELGLCLPDW 

      2230       2240       2250       2260       2270       2280 
RRELCPYPCE EPFVYRACVD CERTCDNYEQ LQTSPEKCTN KPVEGCFCPE GKVRVNNTCI 

      2290       2300       2310       2320       2330       2340 
EPGKCFPCGV DGHYAGDEWQ EDASTLCACA RSPHGTALVG CRATSCAPPV CAHGEDLRTA 

      2350       2360       2370       2380       2390       2400 
PPPPGQCCPE YDCVAKPEAQ CKETKKIVCD YGQVLKQKTN PSGCKEYFCE CKPSSECEVI 

      2410       2420       2430       2440       2450       2460 
PPESEVEIVE AGIHREIDNS GCCPRVSLVC RPETCPKPPH CPQFQTLASV NITGKCCPEY 

      2470       2480       2490       2500       2510       2520 
KCELPKDKCI VTLEWEAAAK GGEKPREKPQ TVLKDLEAVW LDGPCRSCEC ALSGAGPAAT 

      2530       2540       2550       2560       2570       2580 
CAVSACPAVV SSELFVLEPR PVPFACCPEP VQVACRHQDN VYKVGEKWKS PTDVCETYEC 

      2590       2600       2610       2620       2630       2640 
AADGDGKLQR LAAVQRCDRH CQPGWKYVPA EADSGQCCGK CEPVACVVDG EEKPIGEKWT 

      2650       2660       2670       2680       2690       2700 
SSDFCTNFTC VNLNGTLQVQ SSNETCPEIS DAERKQFVLK EQKVPGKCCP KIEREACTSG 

      2710       2720       2730       2740       2750       2760 
RSDIPGRREL DVDRELVREL PMRAGRGRRP ALRGLRAALR DRLPTRLEVL PAPAECCGRC 

      2770       2780       2790       2800       2810       2820 
KPSPASWKGG RGPSGRARER PVGESWTSAD FCTNYTCADL HGTLQVQSSN ETCPEVSEAV 

      2830       2840       2850       2860       2870       2880 
KKQFVLKEEK IPGKCCPKVE PVACRDGDKI YQEVQVWTTP DPCTNRTCRR EDGQLSVGRT 

      2890       2900       2910       2920       2930       2940 
VEHCERQCRR GWTYSPPAAD HCCGRCVQSA CLVDDQLKEP GSTWSSADNC TTFSCDRSGE 

      2950       2960       2970       2980       2990       3000 
EVFVTSATEH CPDVSACDPA DIVNTTCCQI CNEKPQALSK CVLRASELRH CRSDPHPMGA 

      3010       3020       3030       3040       3050       3060 
HGLCVNKFPI TGFTEVHGSC DSGTIYNNQT GTHESACECC QAAKYSGVSV RLTCEDGTVR 

      3070       3080       3090       3100       3110       3120 
PHRVATPARC HCAACGPGLT KHPKPGHASY TGTKNPVQPE RDREYVIPDI SSASGEARRN 

      3130 
HDSNYITTLI ISF

« Hide

References

[1]"Cloning and expression of the gene of hemocytin, an insect humoral lectin which is homologous with the mammalian von Willebrand factor."
Kotani E., Yamakawa M., Iwamoto S., Tashiro M., Mori H., Sumida M., Matsubara F., Taniai K., Kadono-Okuda K., Kato Y., Mori H.
Biochim. Biophys. Acta 1260:245-258(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Fuyou X Tokai.
Tissue: Hemocyte.
[2]Kotani E., Iwamoto S., Tashiro M., Mori H., Sumida M., Matsubara F., Yamakawa M.
Submitted (JAN-1993) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2221-3133.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		D29738 mRNA. Translation: BAA06160.1.
D14035 mRNA. Translation: BAA03124.1.
PIRS52093.
RefSeqNP_001104817.1. NM_001111347.1.
UniGeneBmo.1330.

3D structure databases

ProteinModelPortalP98092.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID692743.

Family and domain databases

InterProIPR000421. Coagulation_fac_5/8-C_type_dom.
IPR006207. Cys_knot_C.
IPR008979. Galactose-bd-like.
IPR012111. Hml.
IPR002172. LDrepeatLR_classA_rpt.
IPR002919. TIL_dom.
IPR014853. Unchr_dom_Cys-rich.
IPR001007. VWF_C.
IPR001846. VWF_type-D.
IPR001878. Znf_CCHC.
[Graphical view]
PfamPF08742. C8. 3 hits.
PF00754. F5_F8_type_C. 2 hits.
PF01826. TIL. 5 hits.
PF00094. VWD. 3 hits.
[Graphical view]
PIRSFPIRSF036569. Hml. 1 hit.
SMARTSM00832. C8. 3 hits.
SM00041. CT. 1 hit.
SM00231. FA58C. 2 hits.
SM00192. LDLa. 1 hit.
SM00214. VWC. 3 hits.
SM00216. VWD. 3 hits.
SM00343. ZnF_C2HC. 1 hit.
[Graphical view]
SUPFAMSSF57567. Cysrich_TIL. 5 hits.
SSF49785. Gal_bind_like. 2 hits.
SSF57424. LDL_rcpt_classA_cys-rich. 1 hit.
PROSITEPS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS01285. FA58C_1. 2 hits.
PS01286. FA58C_2. 2 hits.
PS50022. FA58C_3. 2 hits.
PS01208. VWFC_1. False negative.
PS50184. VWFC_2. False negative.
PS51233. VWFD. 3 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHMCT_BOMMO
AccessionPrimary (citable) accession number: P98092
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: April 3, 2013
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

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