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P98092

- HMCT_BOMMO

UniProt

P98092 - HMCT_BOMMO

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Protein
Hemocytin
Gene
N/A
Organism
Bombyx mori (Silk moth)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Adhesive protein and relates to hemostasis or encapsulation of foreign substances for self-defense.

GO - Molecular functioni

  1. nucleic acid binding Source: InterPro
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. cell adhesion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
Hemocytin
Alternative name(s):
Humoral lectin
OrganismiBombyx mori (Silk moth)
Taxonomic identifieri7091 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaLepidopteraGlossataDitrysiaBombycoideaBombycidaeBombycinaeBombyx
ProteomesiUP000005204: Unplaced

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 3133HemocytinPRO_0000021445
Signal peptidei1 – ? Reviewed prediction

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi? ↔ 3075 By similarity
Glycosylationi151 – 1511N-linked (GlcNAc...) Reviewed prediction
Glycosylationi237 – 2371N-linked (GlcNAc...) Reviewed prediction
Glycosylationi564 – 5641N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi940 ↔ 1095 By similarity
Disulfide bondi1116 ↔ 1254 By similarity
Glycosylationi1170 – 11701N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1387 – 13871N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1622 – 16221N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1727 – 17271N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1847 – 18471N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1975 – 19751N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1985 – 19851N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2093 – 20931N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2113 – 21131N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2161 – 21611N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2276 – 22761N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2451 – 24511N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2647 – 26471N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2654 – 26541N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2663 – 26631N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2794 – 27941N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2810 – 28101N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2865 – 28651N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2929 – 29291N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2964 – 29641N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi2971 ↔ 3040 By similarity
Disulfide bondi2991 ↔ 3054 By similarity
Disulfide bondi3004 ↔ 3070 By similarity
Disulfide bondi3020 ↔ 3072 By similarity
Glycosylationi3028 – 30281N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

May be converted into the 260 kDa mature hemocytin by proteolysis.

Keywords - PTMi

Disulfide bond, Glycoprotein

Expressioni

Developmental stagei

Expressed in hemocytes during larval-pupal metamorphosis.

Inductioni

Hemagglutination activity is increased by bacterial or viral infection and inhibited by D-mannose, N-acetyl-D-galactosamine and D-maltose.

Structurei

3D structure databases

ProteinModelPortaliP98092.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini40 – 9657TIL 1
Add
BLAST
Domaini153 – 20957TIL 2
Add
BLAST
Domaini248 – 455208VWFD 1
Add
BLAST
Domaini509 – 57668TIL 3
Add
BLAST
Domaini770 – 83768TIL 4
Add
BLAST
Domaini940 – 1095156F5/8 type C 1
Add
BLAST
Domaini1116 – 1254139F5/8 type C 2
Add
BLAST
Domaini1619 – 1824206VWFD 2
Add
BLAST
Domaini1890 – 194859TIL 5
Add
BLAST
Domaini1953 – 2179227VWFD 3
Add
BLAST
Domaini2229 – 228557TIL 6
Add
BLAST
Domaini2553 – 262270VWFC 1
Add
BLAST
Domaini2842 – 290766VWFC 2
Add
BLAST
Domaini2971 – 3076106CTCK
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi895 – 91420Poly-Thr
Add
BLAST
Compositional biasi1267 – 12704Poly-Glu
Compositional biasi1425 – 14284Poly-Thr
Compositional biasi1447 – 14504Poly-Thr
Compositional biasi1474 – 14796Poly-Ser
Compositional biasi2148 – 21536Poly-Pro
Compositional biasi2156 – 21594Poly-Pro
Compositional biasi2341 – 23444Poly-Pro

Sequence similaritiesi

Contains 2 F5/8 type C domains.
Contains 2 VWFC domains.
Contains 3 VWFD domains.

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

KOiK03900.

Family and domain databases

Gene3Di2.60.120.260. 2 hits.
InterProiIPR000421. Coagulation_fac_5/8-C_type_dom.
IPR006207. Cys_knot_C.
IPR008979. Galactose-bd-like.
IPR012111. Hml.
IPR002172. LDrepeatLR_classA_rpt.
IPR002919. TIL_dom.
IPR014853. Unchr_dom_Cys-rich.
IPR001007. VWF_C.
IPR001846. VWF_type-D.
IPR001878. Znf_CCHC.
[Graphical view]
PfamiPF08742. C8. 3 hits.
PF00754. F5_F8_type_C. 2 hits.
PF01826. TIL. 5 hits.
PF00094. VWD. 3 hits.
[Graphical view]
PIRSFiPIRSF036569. Hml. 1 hit.
SMARTiSM00832. C8. 3 hits.
SM00041. CT. 1 hit.
SM00231. FA58C. 2 hits.
SM00192. LDLa. 1 hit.
SM00214. VWC. 3 hits.
SM00216. VWD. 3 hits.
SM00343. ZnF_C2HC. 1 hit.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 2 hits.
SSF57567. SSF57567. 4 hits.
PROSITEiPS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS01285. FA58C_1. 2 hits.
PS01286. FA58C_2. 2 hits.
PS50022. FA58C_3. 2 hits.
PS51233. VWFD. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P98092-1 [UniParc]FASTAAdd to Basket

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MRGGRDPVPV PVLGDYAMVC AKNGIILQWR YNVKECELSC TGGQQYTVCA     50
DSCLRKCSDT ALAASGQCKP VCVEGCACSP SQLLDDNGVC VPVAKCPCIH 100
KGLQFNAGYK EIRPGRRERE LCTCVGARWD CKPATPEEIQ NYPPAEDLRS 150
NSTAQNMEFT TCETSEPLTC KNMHLPPSTQ TAECRPGCQC KKGQVLDTAS 200
KRCVPATQCP CHHAGRSYPD GHLMQEECNK CECKNGNWSC TQRKCAGVCG 250
AWGDSHVNTF DGTQYDFEGV CTYLLAKGAM DGTDGFDVEI QNVPCGTTGA 300
TCSKSVTLKV GGAGNEEIVS LTKNAPIPDI SKLKRIKMRK AGAYVFLDVP 350
SLGMSLQWDR GLRVYVKIDT MWQGRVKGLC GNYNGDMRDD FQTPSGGGMS 400
ESSALIFADS WKLKPTCPKP QPVIDHCKQR PERKEWAQSV CGALKRYPFS 450
LCAGEVGAGA YVARCERDAC DAGADCECAC AALAAYAHAC AHRGVTFNWR 500
TNDLCPMQCD EVCSNYDSCV SACPVETCDN ILYYAETTAR CEQDTCVEGC 550
KPKKSCPEGS VYKNDSTTEC VPRAKCKPVC MTLDGGREVL EGEIIEEDAC 600
HTCRCSKKHK VCTGQPCSTE APRIQATSSS AEPATERPHE PLKCVTGWTP 650
WINRGPAEIG PDGQSVESEP LPKPNELQIG KPMCKPEMMK KIECRTVNDH 700
KTPKETGLNV ECSLENGLVC EEPEKTCPDF EIKVYCECEE PQDTSPPVTV 750
TSEASSEPVS TTLATTTSRC PPGEVYQACA YKCDRLCDHF KKTLIAKGRC 800
ISEMCVDGCV DESVASNGCE GSSRWRDERT CVPVKDCTCY NDGQIVKPGG 850
VTESGCIKCQ CLDNSLYCDS KDCVSLNIPH QGSTHLPYIV RPVSTTITST 900
TTTTTTSTTT TTTTPEPTET TTETTVPLII KSTVSPPPEC SPDNYIDLVM 950
GDEPLPDTAF SASSEFSEIF APHNARLNRG PTNSGAGSWN PKVNNDKQYI 1000
QVELPRREPI YGVVLQGSPI FDQYVTSYEI MYGDDGNTFS TVDGPDGKPK 1050
IFRGPIDNTH PVKQMISPPI EAKVVRIRPL TWHDEISLRL EIIGCAEPLT 1100
TETSEPSPTS ESPLQCTEPL GLIGELPLEN IQVSSNSEEK DYLSINGNRG 1150
WKPLYNTPGW VMFDFTGPRN ITGILTKGGN DGWVTSYKVL YTSDFETFNP 1200
VIDKDGKEKI FPANFDGIVS VTNEFHPPIR ARYLKVLPQK WNKNIELRIE 1250
PIGCFEPYPE ILRSLPEEEE GREEPQVVRK EYGMSQEREM PNCHICPGVE 1300
AKECTCSYPE YFDGENCVPR AECPCVESFM TYPVGSTFRG ANCDECVCKL 1350
GGTTECKPFK ECQCDDESLV PKLSPTTCDC TCEPCTNGTK ICKTSKLCLA 1400
LESWCDGVQD CPDDERDCTT STARTTTTEP TVVTTVAPTQ AATAPPTTTT 1450
PKPVVECPKV ECPPGYIISY TTGSSSSYSR AFSSDLPPPR PRYSYQRYYR 1500
GRSTGGYSGY AKTGYSKGGF SKGGFSKGGY GYPSIPRSNQ AFTLDKPALT 1550
NKQPTSKEEC AQFKCISKLP AFKPGVVPPP VACSVVTCPA GYTLKLDKVP 1600
TGYNKCPQYE CVPPLERPVF CNMTGRTFNT FDGMEYKYDV CFHMLARDNK 1650
FDAWLIIVRK NCRLDGCTNE LIVMQDDQLI QVKPNMMVTY NNYEYTIEQT 1700
KKICFQKNSF DVDRLGNGIS ITSRKYNFTV LFNKEGDVKI GVLKKHMGGV 1750
DGLCGAYDGS LANERRLPDG RVATSIDEFG RSWAKPGVPA DACAPRVASA 1800
HKQRRAWDLC NVIAEEPFSQ CGKVLNLDKW RHICLEKICE CTDLVVNGTK 1850
RTEEQCRCLV LQQMAAECLA ADAGVDLASW RLMMDCPADC PPPLVHYDCY 1900
RKRCEETCAP YPNAARACPA QEGQCSPGCY CPDGKLRKGD QCVLPADCLD 1950
CTCTGVGTPA KYTTFEGDDL PFLGNCTYLA SRDRNQTGEH KYQVYATNGP 2000
CDDNANIVCT KIVHLIYEKN VIHISKDPTT KKLRTVIGKT AVFKYPVKEN 2050
WGTISLLNGQ DVSVTLPDIH VELTVSQLNL EFAVRVPTFL YGNRTEGLCG 2100
VCAGYQDFLV TSNGTVTDDF DLYGKSWQAS PEKLTELEVP SDEQCDAPPP 2150
PAPCTPPPPD NNTCYHLYNA DRFGACHALV EPQPYVESCE ADECGGHGPC 2200
DALQRYAAAC AELGLCLPDW RRELCPYPCE EPFVYRACVD CERTCDNYEQ 2250
LQTSPEKCTN KPVEGCFCPE GKVRVNNTCI EPGKCFPCGV DGHYAGDEWQ 2300
EDASTLCACA RSPHGTALVG CRATSCAPPV CAHGEDLRTA PPPPGQCCPE 2350
YDCVAKPEAQ CKETKKIVCD YGQVLKQKTN PSGCKEYFCE CKPSSECEVI 2400
PPESEVEIVE AGIHREIDNS GCCPRVSLVC RPETCPKPPH CPQFQTLASV 2450
NITGKCCPEY KCELPKDKCI VTLEWEAAAK GGEKPREKPQ TVLKDLEAVW 2500
LDGPCRSCEC ALSGAGPAAT CAVSACPAVV SSELFVLEPR PVPFACCPEP 2550
VQVACRHQDN VYKVGEKWKS PTDVCETYEC AADGDGKLQR LAAVQRCDRH 2600
CQPGWKYVPA EADSGQCCGK CEPVACVVDG EEKPIGEKWT SSDFCTNFTC 2650
VNLNGTLQVQ SSNETCPEIS DAERKQFVLK EQKVPGKCCP KIEREACTSG 2700
RSDIPGRREL DVDRELVREL PMRAGRGRRP ALRGLRAALR DRLPTRLEVL 2750
PAPAECCGRC KPSPASWKGG RGPSGRARER PVGESWTSAD FCTNYTCADL 2800
HGTLQVQSSN ETCPEVSEAV KKQFVLKEEK IPGKCCPKVE PVACRDGDKI 2850
YQEVQVWTTP DPCTNRTCRR EDGQLSVGRT VEHCERQCRR GWTYSPPAAD 2900
HCCGRCVQSA CLVDDQLKEP GSTWSSADNC TTFSCDRSGE EVFVTSATEH 2950
CPDVSACDPA DIVNTTCCQI CNEKPQALSK CVLRASELRH CRSDPHPMGA 3000
HGLCVNKFPI TGFTEVHGSC DSGTIYNNQT GTHESACECC QAAKYSGVSV 3050
RLTCEDGTVR PHRVATPARC HCAACGPGLT KHPKPGHASY TGTKNPVQPE 3100
RDREYVIPDI SSASGEARRN HDSNYITTLI ISF 3133
Length:3,133
Mass (Da):343,355
Last modified:February 1, 1996 - v1
Checksum:iE5210D5D14A7B2B2
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti1288 – 12881R → G.
Natural varianti1305 – 13051T → S.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D29738 mRNA. Translation: BAA06160.1.
D14035 mRNA. Translation: BAA03124.1.
PIRiS52093.
RefSeqiNP_001104817.1. NM_001111347.1.
UniGeneiBmo.1330.

Genome annotation databases

GeneIDi692743.
KEGGibmor:692743.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D29738 mRNA. Translation: BAA06160.1 .
D14035 mRNA. Translation: BAA03124.1 .
PIRi S52093.
RefSeqi NP_001104817.1. NM_001111347.1.
UniGenei Bmo.1330.

3D structure databases

ProteinModelPortali P98092.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 692743.
KEGGi bmor:692743.

Phylogenomic databases

KOi K03900.

Family and domain databases

Gene3Di 2.60.120.260. 2 hits.
InterProi IPR000421. Coagulation_fac_5/8-C_type_dom.
IPR006207. Cys_knot_C.
IPR008979. Galactose-bd-like.
IPR012111. Hml.
IPR002172. LDrepeatLR_classA_rpt.
IPR002919. TIL_dom.
IPR014853. Unchr_dom_Cys-rich.
IPR001007. VWF_C.
IPR001846. VWF_type-D.
IPR001878. Znf_CCHC.
[Graphical view ]
Pfami PF08742. C8. 3 hits.
PF00754. F5_F8_type_C. 2 hits.
PF01826. TIL. 5 hits.
PF00094. VWD. 3 hits.
[Graphical view ]
PIRSFi PIRSF036569. Hml. 1 hit.
SMARTi SM00832. C8. 3 hits.
SM00041. CT. 1 hit.
SM00231. FA58C. 2 hits.
SM00192. LDLa. 1 hit.
SM00214. VWC. 3 hits.
SM00216. VWD. 3 hits.
SM00343. ZnF_C2HC. 1 hit.
[Graphical view ]
SUPFAMi SSF49785. SSF49785. 2 hits.
SSF57567. SSF57567. 4 hits.
PROSITEi PS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS01285. FA58C_1. 2 hits.
PS01286. FA58C_2. 2 hits.
PS50022. FA58C_3. 2 hits.
PS51233. VWFD. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and expression of the gene of hemocytin, an insect humoral lectin which is homologous with the mammalian von Willebrand factor."
    Kotani E., Yamakawa M., Iwamoto S., Tashiro M., Mori H., Sumida M., Matsubara F., Taniai K., Kadono-Okuda K., Kato Y., Mori H.
    Biochim. Biophys. Acta 1260:245-258(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Fuyou X Tokai.
    Tissue: Hemocyte.
  2. Kotani E., Iwamoto S., Tashiro M., Mori H., Sumida M., Matsubara F., Yamakawa M.
    Submitted (JAN-1993) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2221-3133.

Entry informationi

Entry nameiHMCT_BOMMO
AccessioniPrimary (citable) accession number: P98092
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: February 19, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3