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P98092

- HMCT_BOMMO

UniProt

P98092 - HMCT_BOMMO

Protein

Hemocytin

Gene
N/A
Organism
Bombyx mori (Silk moth)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Adhesive protein and relates to hemostasis or encapsulation of foreign substances for self-defense.

    GO - Molecular functioni

    1. nucleic acid binding Source: InterPro
    2. zinc ion binding Source: InterPro

    GO - Biological processi

    1. cell adhesion Source: UniProtKB-KW

    Keywords - Biological processi

    Cell adhesion

    Keywords - Ligandi

    Lectin

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hemocytin
    Alternative name(s):
    Humoral lectin
    OrganismiBombyx mori (Silk moth)
    Taxonomic identifieri7091 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaLepidopteraGlossataDitrysiaBombycoideaBombycidaeBombycinaeBombyx
    ProteomesiUP000005204: Unplaced

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini? – 3133HemocytinPRO_0000021445
    Signal peptidei1 – ?Sequence Analysis

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi? ↔ 3075By similarity
    Glycosylationi151 – 1511N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi237 – 2371N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi564 – 5641N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi940 ↔ 1095By similarity
    Disulfide bondi1116 ↔ 1254By similarity
    Glycosylationi1170 – 11701N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1387 – 13871N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1622 – 16221N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1727 – 17271N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1847 – 18471N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1975 – 19751N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1985 – 19851N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2093 – 20931N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2113 – 21131N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2161 – 21611N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2276 – 22761N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2451 – 24511N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2647 – 26471N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2654 – 26541N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2663 – 26631N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2794 – 27941N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2810 – 28101N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2865 – 28651N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2929 – 29291N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2964 – 29641N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi2971 ↔ 3040By similarity
    Disulfide bondi2991 ↔ 3054By similarity
    Disulfide bondi3004 ↔ 3070By similarity
    Disulfide bondi3020 ↔ 3072By similarity
    Glycosylationi3028 – 30281N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    May be converted into the 260 kDa mature hemocytin by proteolysis.

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Expressioni

    Developmental stagei

    Expressed in hemocytes during larval-pupal metamorphosis.

    Inductioni

    Hemagglutination activity is increased by bacterial or viral infection and inhibited by D-mannose, N-acetyl-D-galactosamine and D-maltose.

    Structurei

    3D structure databases

    ProteinModelPortaliP98092.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini40 – 9657TIL 1Add
    BLAST
    Domaini153 – 20957TIL 2Add
    BLAST
    Domaini248 – 455208VWFD 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini509 – 57668TIL 3Add
    BLAST
    Domaini770 – 83768TIL 4Add
    BLAST
    Domaini940 – 1095156F5/8 type C 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini1116 – 1254139F5/8 type C 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini1619 – 1824206VWFD 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini1890 – 194859TIL 5Add
    BLAST
    Domaini1953 – 2179227VWFD 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini2229 – 228557TIL 6Add
    BLAST
    Domaini2553 – 262270VWFC 1Add
    BLAST
    Domaini2842 – 290766VWFC 2Add
    BLAST
    Domaini2971 – 3076106CTCKPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi895 – 91420Poly-ThrAdd
    BLAST
    Compositional biasi1267 – 12704Poly-Glu
    Compositional biasi1425 – 14284Poly-Thr
    Compositional biasi1447 – 14504Poly-Thr
    Compositional biasi1474 – 14796Poly-Ser
    Compositional biasi2148 – 21536Poly-Pro
    Compositional biasi2156 – 21594Poly-Pro
    Compositional biasi2341 – 23444Poly-Pro

    Sequence similaritiesi

    Contains 1 CTCK (C-terminal cystine knot-like) domain.PROSITE-ProRule annotation
    Contains 2 F5/8 type C domains.PROSITE-ProRule annotation
    Contains 2 VWFC domains.Curated
    Contains 3 VWFD domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    KOiK03900.

    Family and domain databases

    Gene3Di2.60.120.260. 2 hits.
    InterProiIPR000421. Coagulation_fac_5/8-C_type_dom.
    IPR006207. Cys_knot_C.
    IPR008979. Galactose-bd-like.
    IPR012111. Hml.
    IPR002172. LDrepeatLR_classA_rpt.
    IPR002919. TIL_dom.
    IPR014853. Unchr_dom_Cys-rich.
    IPR001007. VWF_C.
    IPR001846. VWF_type-D.
    IPR001878. Znf_CCHC.
    [Graphical view]
    PfamiPF08742. C8. 3 hits.
    PF00754. F5_F8_type_C. 2 hits.
    PF01826. TIL. 5 hits.
    PF00094. VWD. 3 hits.
    [Graphical view]
    PIRSFiPIRSF036569. Hml. 1 hit.
    SMARTiSM00832. C8. 3 hits.
    SM00041. CT. 1 hit.
    SM00231. FA58C. 2 hits.
    SM00192. LDLa. 1 hit.
    SM00214. VWC. 3 hits.
    SM00216. VWD. 3 hits.
    SM00343. ZnF_C2HC. 1 hit.
    [Graphical view]
    SUPFAMiSSF49785. SSF49785. 2 hits.
    SSF57567. SSF57567. 4 hits.
    PROSITEiPS01185. CTCK_1. 1 hit.
    PS01225. CTCK_2. 1 hit.
    PS01285. FA58C_1. 2 hits.
    PS01286. FA58C_2. 2 hits.
    PS50022. FA58C_3. 2 hits.
    PS51233. VWFD. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P98092-1 [UniParc]FASTAAdd to Basket

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    MRGGRDPVPV PVLGDYAMVC AKNGIILQWR YNVKECELSC TGGQQYTVCA     50
    DSCLRKCSDT ALAASGQCKP VCVEGCACSP SQLLDDNGVC VPVAKCPCIH 100
    KGLQFNAGYK EIRPGRRERE LCTCVGARWD CKPATPEEIQ NYPPAEDLRS 150
    NSTAQNMEFT TCETSEPLTC KNMHLPPSTQ TAECRPGCQC KKGQVLDTAS 200
    KRCVPATQCP CHHAGRSYPD GHLMQEECNK CECKNGNWSC TQRKCAGVCG 250
    AWGDSHVNTF DGTQYDFEGV CTYLLAKGAM DGTDGFDVEI QNVPCGTTGA 300
    TCSKSVTLKV GGAGNEEIVS LTKNAPIPDI SKLKRIKMRK AGAYVFLDVP 350
    SLGMSLQWDR GLRVYVKIDT MWQGRVKGLC GNYNGDMRDD FQTPSGGGMS 400
    ESSALIFADS WKLKPTCPKP QPVIDHCKQR PERKEWAQSV CGALKRYPFS 450
    LCAGEVGAGA YVARCERDAC DAGADCECAC AALAAYAHAC AHRGVTFNWR 500
    TNDLCPMQCD EVCSNYDSCV SACPVETCDN ILYYAETTAR CEQDTCVEGC 550
    KPKKSCPEGS VYKNDSTTEC VPRAKCKPVC MTLDGGREVL EGEIIEEDAC 600
    HTCRCSKKHK VCTGQPCSTE APRIQATSSS AEPATERPHE PLKCVTGWTP 650
    WINRGPAEIG PDGQSVESEP LPKPNELQIG KPMCKPEMMK KIECRTVNDH 700
    KTPKETGLNV ECSLENGLVC EEPEKTCPDF EIKVYCECEE PQDTSPPVTV 750
    TSEASSEPVS TTLATTTSRC PPGEVYQACA YKCDRLCDHF KKTLIAKGRC 800
    ISEMCVDGCV DESVASNGCE GSSRWRDERT CVPVKDCTCY NDGQIVKPGG 850
    VTESGCIKCQ CLDNSLYCDS KDCVSLNIPH QGSTHLPYIV RPVSTTITST 900
    TTTTTTSTTT TTTTPEPTET TTETTVPLII KSTVSPPPEC SPDNYIDLVM 950
    GDEPLPDTAF SASSEFSEIF APHNARLNRG PTNSGAGSWN PKVNNDKQYI 1000
    QVELPRREPI YGVVLQGSPI FDQYVTSYEI MYGDDGNTFS TVDGPDGKPK 1050
    IFRGPIDNTH PVKQMISPPI EAKVVRIRPL TWHDEISLRL EIIGCAEPLT 1100
    TETSEPSPTS ESPLQCTEPL GLIGELPLEN IQVSSNSEEK DYLSINGNRG 1150
    WKPLYNTPGW VMFDFTGPRN ITGILTKGGN DGWVTSYKVL YTSDFETFNP 1200
    VIDKDGKEKI FPANFDGIVS VTNEFHPPIR ARYLKVLPQK WNKNIELRIE 1250
    PIGCFEPYPE ILRSLPEEEE GREEPQVVRK EYGMSQEREM PNCHICPGVE 1300
    AKECTCSYPE YFDGENCVPR AECPCVESFM TYPVGSTFRG ANCDECVCKL 1350
    GGTTECKPFK ECQCDDESLV PKLSPTTCDC TCEPCTNGTK ICKTSKLCLA 1400
    LESWCDGVQD CPDDERDCTT STARTTTTEP TVVTTVAPTQ AATAPPTTTT 1450
    PKPVVECPKV ECPPGYIISY TTGSSSSYSR AFSSDLPPPR PRYSYQRYYR 1500
    GRSTGGYSGY AKTGYSKGGF SKGGFSKGGY GYPSIPRSNQ AFTLDKPALT 1550
    NKQPTSKEEC AQFKCISKLP AFKPGVVPPP VACSVVTCPA GYTLKLDKVP 1600
    TGYNKCPQYE CVPPLERPVF CNMTGRTFNT FDGMEYKYDV CFHMLARDNK 1650
    FDAWLIIVRK NCRLDGCTNE LIVMQDDQLI QVKPNMMVTY NNYEYTIEQT 1700
    KKICFQKNSF DVDRLGNGIS ITSRKYNFTV LFNKEGDVKI GVLKKHMGGV 1750
    DGLCGAYDGS LANERRLPDG RVATSIDEFG RSWAKPGVPA DACAPRVASA 1800
    HKQRRAWDLC NVIAEEPFSQ CGKVLNLDKW RHICLEKICE CTDLVVNGTK 1850
    RTEEQCRCLV LQQMAAECLA ADAGVDLASW RLMMDCPADC PPPLVHYDCY 1900
    RKRCEETCAP YPNAARACPA QEGQCSPGCY CPDGKLRKGD QCVLPADCLD 1950
    CTCTGVGTPA KYTTFEGDDL PFLGNCTYLA SRDRNQTGEH KYQVYATNGP 2000
    CDDNANIVCT KIVHLIYEKN VIHISKDPTT KKLRTVIGKT AVFKYPVKEN 2050
    WGTISLLNGQ DVSVTLPDIH VELTVSQLNL EFAVRVPTFL YGNRTEGLCG 2100
    VCAGYQDFLV TSNGTVTDDF DLYGKSWQAS PEKLTELEVP SDEQCDAPPP 2150
    PAPCTPPPPD NNTCYHLYNA DRFGACHALV EPQPYVESCE ADECGGHGPC 2200
    DALQRYAAAC AELGLCLPDW RRELCPYPCE EPFVYRACVD CERTCDNYEQ 2250
    LQTSPEKCTN KPVEGCFCPE GKVRVNNTCI EPGKCFPCGV DGHYAGDEWQ 2300
    EDASTLCACA RSPHGTALVG CRATSCAPPV CAHGEDLRTA PPPPGQCCPE 2350
    YDCVAKPEAQ CKETKKIVCD YGQVLKQKTN PSGCKEYFCE CKPSSECEVI 2400
    PPESEVEIVE AGIHREIDNS GCCPRVSLVC RPETCPKPPH CPQFQTLASV 2450
    NITGKCCPEY KCELPKDKCI VTLEWEAAAK GGEKPREKPQ TVLKDLEAVW 2500
    LDGPCRSCEC ALSGAGPAAT CAVSACPAVV SSELFVLEPR PVPFACCPEP 2550
    VQVACRHQDN VYKVGEKWKS PTDVCETYEC AADGDGKLQR LAAVQRCDRH 2600
    CQPGWKYVPA EADSGQCCGK CEPVACVVDG EEKPIGEKWT SSDFCTNFTC 2650
    VNLNGTLQVQ SSNETCPEIS DAERKQFVLK EQKVPGKCCP KIEREACTSG 2700
    RSDIPGRREL DVDRELVREL PMRAGRGRRP ALRGLRAALR DRLPTRLEVL 2750
    PAPAECCGRC KPSPASWKGG RGPSGRARER PVGESWTSAD FCTNYTCADL 2800
    HGTLQVQSSN ETCPEVSEAV KKQFVLKEEK IPGKCCPKVE PVACRDGDKI 2850
    YQEVQVWTTP DPCTNRTCRR EDGQLSVGRT VEHCERQCRR GWTYSPPAAD 2900
    HCCGRCVQSA CLVDDQLKEP GSTWSSADNC TTFSCDRSGE EVFVTSATEH 2950
    CPDVSACDPA DIVNTTCCQI CNEKPQALSK CVLRASELRH CRSDPHPMGA 3000
    HGLCVNKFPI TGFTEVHGSC DSGTIYNNQT GTHESACECC QAAKYSGVSV 3050
    RLTCEDGTVR PHRVATPARC HCAACGPGLT KHPKPGHASY TGTKNPVQPE 3100
    RDREYVIPDI SSASGEARRN HDSNYITTLI ISF 3133
    Length:3,133
    Mass (Da):343,355
    Last modified:February 1, 1996 - v1
    Checksum:iE5210D5D14A7B2B2
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti1288 – 12881R → G.
    Natural varianti1305 – 13051T → S.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D29738 mRNA. Translation: BAA06160.1.
    D14035 mRNA. Translation: BAA03124.1.
    PIRiS52093.
    RefSeqiNP_001104817.1. NM_001111347.1.
    UniGeneiBmo.1330.

    Genome annotation databases

    GeneIDi692743.
    KEGGibmor:692743.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D29738 mRNA. Translation: BAA06160.1 .
    D14035 mRNA. Translation: BAA03124.1 .
    PIRi S52093.
    RefSeqi NP_001104817.1. NM_001111347.1.
    UniGenei Bmo.1330.

    3D structure databases

    ProteinModelPortali P98092.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 692743.
    KEGGi bmor:692743.

    Phylogenomic databases

    KOi K03900.

    Family and domain databases

    Gene3Di 2.60.120.260. 2 hits.
    InterProi IPR000421. Coagulation_fac_5/8-C_type_dom.
    IPR006207. Cys_knot_C.
    IPR008979. Galactose-bd-like.
    IPR012111. Hml.
    IPR002172. LDrepeatLR_classA_rpt.
    IPR002919. TIL_dom.
    IPR014853. Unchr_dom_Cys-rich.
    IPR001007. VWF_C.
    IPR001846. VWF_type-D.
    IPR001878. Znf_CCHC.
    [Graphical view ]
    Pfami PF08742. C8. 3 hits.
    PF00754. F5_F8_type_C. 2 hits.
    PF01826. TIL. 5 hits.
    PF00094. VWD. 3 hits.
    [Graphical view ]
    PIRSFi PIRSF036569. Hml. 1 hit.
    SMARTi SM00832. C8. 3 hits.
    SM00041. CT. 1 hit.
    SM00231. FA58C. 2 hits.
    SM00192. LDLa. 1 hit.
    SM00214. VWC. 3 hits.
    SM00216. VWD. 3 hits.
    SM00343. ZnF_C2HC. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49785. SSF49785. 2 hits.
    SSF57567. SSF57567. 4 hits.
    PROSITEi PS01185. CTCK_1. 1 hit.
    PS01225. CTCK_2. 1 hit.
    PS01285. FA58C_1. 2 hits.
    PS01286. FA58C_2. 2 hits.
    PS50022. FA58C_3. 2 hits.
    PS51233. VWFD. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and expression of the gene of hemocytin, an insect humoral lectin which is homologous with the mammalian von Willebrand factor."
      Kotani E., Yamakawa M., Iwamoto S., Tashiro M., Mori H., Sumida M., Matsubara F., Taniai K., Kadono-Okuda K., Kato Y., Mori H.
      Biochim. Biophys. Acta 1260:245-258(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Fuyou X Tokai.
      Tissue: Hemocyte.
    2. Kotani E., Iwamoto S., Tashiro M., Mori H., Sumida M., Matsubara F., Yamakawa M.
      Submitted (JAN-1993) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2221-3133.

    Entry informationi

    Entry nameiHMCT_BOMMO
    AccessioniPrimary (citable) accession number: P98092
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 96 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3