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P98089

- MUC2L_RAT

UniProt

P98089 - MUC2L_RAT

Protein

Intestinal mucin-like protein

Gene
N/A
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Intestinal mucin-like protein
    Short name:
    MLP
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi1594023. LOC682824.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini‹1 – 837›837Intestinal mucin-like proteinPRO_0000158959Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi? ↔ 816By similarity
    Glycosylationi91 – 911N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi164 – 1641N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi278 – 2781N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi289 – 2891N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi344 – 3441N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi410 – 4101N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi444 – 4441N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi515 – 5151N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi538 – 5381N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi612 – 6121N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi627 – 6271N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi695 – 6951N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi727 – 7271N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi732 ↔ 779By similarity
    Disulfide bondi746 ↔ 793By similarity
    Glycosylationi749 – 7491N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi755 ↔ 809By similarity
    Disulfide bondi759 ↔ 811By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiP98089.

    Expressioni

    Tissue specificityi

    Coats the epithelia of the intestines.

    Gene expression databases

    GenevestigatoriP98089.

    Interactioni

    Subunit structurei

    Multimeric.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati17 – 27111Add
    BLAST
    Repeati28 – 38112Add
    BLAST
    Repeati39 – 50123Add
    BLAST
    Repeati51 – 62124Add
    BLAST
    Repeati63 – 7085; truncated
    Domaini142 – 365224VWFDPROSITE-ProRule annotationAdd
    BLAST
    Domaini472 – 54372VWFC 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini581 – 64868VWFC 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini732 – 81786CTCKPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni17 – 70545 X 11 AA approximate tandem repeatsAdd
    BLAST
    Regioni149 – 837689Probably important for disulfide-bond mediated mucin polymerization (link domain)Add
    BLAST

    Sequence similaritiesi

    Contains 1 CTCK (C-terminal cystine knot-like) domain.PROSITE-ProRule annotation
    Contains 2 VWFC domains.PROSITE-ProRule annotation
    Contains 1 VWFD domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    HOVERGENiHBG071087.
    PhylomeDBiP98089.

    Family and domain databases

    InterProiIPR006207. Cys_knot_C.
    IPR006208. Glyco_hormone_CN.
    IPR002919. TIL_dom.
    IPR014853. Unchr_dom_Cys-rich.
    IPR001007. VWF_C.
    IPR001846. VWF_type-D.
    [Graphical view]
    PfamiPF08742. C8. 1 hit.
    PF00007. Cys_knot. 1 hit.
    PF00094. VWD. 1 hit.
    [Graphical view]
    SMARTiSM00832. C8. 1 hit.
    SM00041. CT. 1 hit.
    SM00214. VWC. 2 hits.
    SM00216. VWD. 1 hit.
    [Graphical view]
    SUPFAMiSSF57567. SSF57567. 1 hit.
    PROSITEiPS01185. CTCK_1. 1 hit.
    PS01225. CTCK_2. 1 hit.
    PS00022. EGF_1. 1 hit.
    PS01208. VWFC_1. 2 hits.
    PS50184. VWFC_2. 2 hits.
    PS51233. VWFD. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    P98089-1 [UniParc]FASTAAdd to Basket

    « Hide

    VNCSVDCQLQ VFNWSCPSTP STPPPSTPTT PTSSQTTTPS TPSTTSSKST    50
    PSTPQSTSSK STPSTPPKTT LPGCLDFDPP RQVNETWWLC NCTMAICKYD 100
    NVVEIVELEC NPPPMPTCSN GLKPVRVPDP DGCCWHWECD CYCTGWGDPH 150
    FVTFDGLYYS YQGNCTYVLV EEITPTVDNF GVYIDNYHCD ANDKVSCPRT 200
    LIVHHETQEV LIKTVHMMPI EVEVQVNKQL VALPYKKYGL EVYQSGINFV 250
    VDIPRLGAQV SYNGLSFSIR LPYHLFGNNT KGQCGTCTNN TADDCILPSG 300
    EIISNCEVAA DEWLVNDPSK PHCPHKGLTT KRPAITTPGP FPENCTVSPV 350
    CQLIMDSLFS QCHPFVPPKH YYEACLFDSC FVAGSGMECA SVQAYAALCA 400
    QEGVCIDWRN HTQGACAVTC PAHRQYQACG PSEEPTCQSS SPKNSTLLVE 450
    GCFCPEGTTK FAPGYDVCVK ICGCVGPDNV PREFGEHFEF DCKDCVCLEG 500
    GSGIVCQPKK CARGNLTTCE EDGTYLVVEA DPDDKCCNTT SCKCDPKRCK 550
    AERPSCLLGF EVKSEHVPGK CCPVYSCVPK GVCVHENAEY QPGSPVYSNK 600
    CQDCVCTDSM DNSTQLNVIS CTHVPCNISC SSGFELVEVP GECCKKCQQT 650
    HCIIKRPEQQ YIILKPGEIQ KNPNDRCTFF SCMKINNQLI SSVSNITCPD 700
    FDPSDCVPGS ITYMPNGCCK TCIHNPNNTV PCSAIPVMKE ISYNGCAKNI 750
    SMNFCAGSCG TFAMYSAQAQ DLDHGCSCCR EERTSVRMVS LDCPDGSKLS 800
    HSYTHIESCL CQGTVCELPQ AQQSRTRRSS PRLLGRK 837
    Length:837
    Mass (Da):91,500
    Last modified:February 1, 1996 - v1
    Checksum:i6335BCDCAC897F35
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M81920 mRNA. No translation available.
    PIRiA42112.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M81920 mRNA. No translation available.
    PIRi A42112.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P98089.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    RGDi 1594023. LOC682824.

    Phylogenomic databases

    HOVERGENi HBG071087.
    PhylomeDBi P98089.

    Gene expression databases

    Genevestigatori P98089.

    Family and domain databases

    InterProi IPR006207. Cys_knot_C.
    IPR006208. Glyco_hormone_CN.
    IPR002919. TIL_dom.
    IPR014853. Unchr_dom_Cys-rich.
    IPR001007. VWF_C.
    IPR001846. VWF_type-D.
    [Graphical view ]
    Pfami PF08742. C8. 1 hit.
    PF00007. Cys_knot. 1 hit.
    PF00094. VWD. 1 hit.
    [Graphical view ]
    SMARTi SM00832. C8. 1 hit.
    SM00041. CT. 1 hit.
    SM00214. VWC. 2 hits.
    SM00216. VWD. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57567. SSF57567. 1 hit.
    PROSITEi PS01185. CTCK_1. 1 hit.
    PS01225. CTCK_2. 1 hit.
    PS00022. EGF_1. 1 hit.
    PS01208. VWFC_1. 2 hits.
    PS50184. VWFC_2. 2 hits.
    PS51233. VWFD. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "cDNA for the carboxyl-terminal region of a rat intestinal mucin-like peptide."
      Xu G., Huan L.-J., Khatri I., Wang D., Bennick A., Fahim R.E.F., Forstner G.G., Forstner J.F.
      J. Biol. Chem. 267:5401-5407(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Intestine.

    Entry informationi

    Entry nameiMUC2L_RAT
    AccessioniPrimary (citable) accession number: P98089
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3