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P98089

- MUC2L_RAT

UniProt

P98089 - MUC2L_RAT

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Protein
Intestinal mucin-like protein
Gene
N/A
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Intestinal mucin-like protein
Short name:
MLP
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi1594023. LOC682824.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – 837›837Intestinal mucin-like protein
PRO_0000158959Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi? ↔ 816 By similarity
Glycosylationi91 – 911N-linked (GlcNAc...) Reviewed prediction
Glycosylationi164 – 1641N-linked (GlcNAc...) Reviewed prediction
Glycosylationi278 – 2781N-linked (GlcNAc...) Reviewed prediction
Glycosylationi289 – 2891N-linked (GlcNAc...) Reviewed prediction
Glycosylationi344 – 3441N-linked (GlcNAc...) Reviewed prediction
Glycosylationi410 – 4101N-linked (GlcNAc...) Reviewed prediction
Glycosylationi444 – 4441N-linked (GlcNAc...) Reviewed prediction
Glycosylationi515 – 5151N-linked (GlcNAc...) Reviewed prediction
Glycosylationi538 – 5381N-linked (GlcNAc...) Reviewed prediction
Glycosylationi612 – 6121N-linked (GlcNAc...) Reviewed prediction
Glycosylationi627 – 6271N-linked (GlcNAc...) Reviewed prediction
Glycosylationi695 – 6951N-linked (GlcNAc...) Reviewed prediction
Glycosylationi727 – 7271N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi732 ↔ 779 By similarity
Disulfide bondi746 ↔ 793 By similarity
Glycosylationi749 – 7491N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi755 ↔ 809 By similarity
Disulfide bondi759 ↔ 811 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP98089.

Expressioni

Tissue specificityi

Coats the epithelia of the intestines.

Gene expression databases

GenevestigatoriP98089.

Interactioni

Subunit structurei

Multimeric.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati17 – 27111
Add
BLAST
Repeati28 – 38112
Add
BLAST
Repeati39 – 50123
Add
BLAST
Repeati51 – 62124
Add
BLAST
Repeati63 – 7085; truncated
Domaini142 – 365224VWFD
Add
BLAST
Domaini472 – 54372VWFC 1
Add
BLAST
Domaini581 – 64868VWFC 2
Add
BLAST
Domaini732 – 81786CTCK
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni17 – 70545 X 11 AA approximate tandem repeats
Add
BLAST
Regioni149 – 837689Probably important for disulfide-bond mediated mucin polymerization (link domain)
Add
BLAST

Sequence similaritiesi

Contains 2 VWFC domains.
Contains 1 VWFD domain.

Keywords - Domaini

Repeat

Phylogenomic databases

HOVERGENiHBG071087.
PhylomeDBiP98089.

Family and domain databases

InterProiIPR006207. Cys_knot_C.
IPR006208. Glyco_hormone_CN.
IPR002919. TIL_dom.
IPR014853. Unchr_dom_Cys-rich.
IPR001007. VWF_C.
IPR001846. VWF_type-D.
[Graphical view]
PfamiPF08742. C8. 1 hit.
PF00007. Cys_knot. 1 hit.
PF00094. VWD. 1 hit.
[Graphical view]
SMARTiSM00832. C8. 1 hit.
SM00041. CT. 1 hit.
SM00214. VWC. 2 hits.
SM00216. VWD. 1 hit.
[Graphical view]
SUPFAMiSSF57567. SSF57567. 1 hit.
PROSITEiPS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS00022. EGF_1. 1 hit.
PS01208. VWFC_1. 2 hits.
PS50184. VWFC_2. 2 hits.
PS51233. VWFD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

P98089-1 [UniParc]FASTAAdd to Basket

« Hide

VNCSVDCQLQ VFNWSCPSTP STPPPSTPTT PTSSQTTTPS TPSTTSSKST    50
PSTPQSTSSK STPSTPPKTT LPGCLDFDPP RQVNETWWLC NCTMAICKYD 100
NVVEIVELEC NPPPMPTCSN GLKPVRVPDP DGCCWHWECD CYCTGWGDPH 150
FVTFDGLYYS YQGNCTYVLV EEITPTVDNF GVYIDNYHCD ANDKVSCPRT 200
LIVHHETQEV LIKTVHMMPI EVEVQVNKQL VALPYKKYGL EVYQSGINFV 250
VDIPRLGAQV SYNGLSFSIR LPYHLFGNNT KGQCGTCTNN TADDCILPSG 300
EIISNCEVAA DEWLVNDPSK PHCPHKGLTT KRPAITTPGP FPENCTVSPV 350
CQLIMDSLFS QCHPFVPPKH YYEACLFDSC FVAGSGMECA SVQAYAALCA 400
QEGVCIDWRN HTQGACAVTC PAHRQYQACG PSEEPTCQSS SPKNSTLLVE 450
GCFCPEGTTK FAPGYDVCVK ICGCVGPDNV PREFGEHFEF DCKDCVCLEG 500
GSGIVCQPKK CARGNLTTCE EDGTYLVVEA DPDDKCCNTT SCKCDPKRCK 550
AERPSCLLGF EVKSEHVPGK CCPVYSCVPK GVCVHENAEY QPGSPVYSNK 600
CQDCVCTDSM DNSTQLNVIS CTHVPCNISC SSGFELVEVP GECCKKCQQT 650
HCIIKRPEQQ YIILKPGEIQ KNPNDRCTFF SCMKINNQLI SSVSNITCPD 700
FDPSDCVPGS ITYMPNGCCK TCIHNPNNTV PCSAIPVMKE ISYNGCAKNI 750
SMNFCAGSCG TFAMYSAQAQ DLDHGCSCCR EERTSVRMVS LDCPDGSKLS 800
HSYTHIESCL CQGTVCELPQ AQQSRTRRSS PRLLGRK 837
Length:837
Mass (Da):91,500
Last modified:February 1, 1996 - v1
Checksum:i6335BCDCAC897F35
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M81920 mRNA. No translation available.
PIRiA42112.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M81920 mRNA. No translation available.
PIRi A42112.

3D structure databases

ModBasei Search...

Proteomic databases

PRIDEi P98089.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

RGDi 1594023. LOC682824.

Phylogenomic databases

HOVERGENi HBG071087.
PhylomeDBi P98089.

Gene expression databases

Genevestigatori P98089.

Family and domain databases

InterProi IPR006207. Cys_knot_C.
IPR006208. Glyco_hormone_CN.
IPR002919. TIL_dom.
IPR014853. Unchr_dom_Cys-rich.
IPR001007. VWF_C.
IPR001846. VWF_type-D.
[Graphical view ]
Pfami PF08742. C8. 1 hit.
PF00007. Cys_knot. 1 hit.
PF00094. VWD. 1 hit.
[Graphical view ]
SMARTi SM00832. C8. 1 hit.
SM00041. CT. 1 hit.
SM00214. VWC. 2 hits.
SM00216. VWD. 1 hit.
[Graphical view ]
SUPFAMi SSF57567. SSF57567. 1 hit.
PROSITEi PS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS00022. EGF_1. 1 hit.
PS01208. VWFC_1. 2 hits.
PS50184. VWFC_2. 2 hits.
PS51233. VWFD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "cDNA for the carboxyl-terminal region of a rat intestinal mucin-like peptide."
    Xu G., Huan L.-J., Khatri I., Wang D., Bennick A., Fahim R.E.F., Forstner G.G., Forstner J.F.
    J. Biol. Chem. 267:5401-5407(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Intestine.

Entry informationi

Entry nameiMUC2L_RAT
AccessioniPrimary (citable) accession number: P98089
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: April 16, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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