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P98089 (MUC2L_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Intestinal mucin-like protein
Short name=MLP
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length837 AA.
Sequence statusFragment.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subunit structure

Multimeric.

Subcellular location

Secreted.

Tissue specificity

Coats the epithelia of the intestines.

Sequence similarities

Contains 1 CTCK (C-terminal cystine knot-like) domain.

Contains 2 VWFC domains.

Contains 1 VWFD domain.

Ontologies

Keywords
   Cellular componentSecreted
   DomainRepeat
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – 837›837Intestinal mucin-like protein
PRO_0000158959

Regions

Repeat17 – 27111
Repeat28 – 38112
Repeat39 – 50123
Repeat51 – 62124
Repeat63 – 7085; truncated
Domain142 – 365224VWFD
Domain472 – 54372VWFC 1
Domain581 – 64868VWFC 2
Domain732 – 81786CTCK
Region17 – 70545 X 11 AA approximate tandem repeats
Region149 – 837689Probably important for disulfide-bond mediated mucin polymerization (link domain)

Amino acid modifications

Glycosylation911N-linked (GlcNAc...) Potential
Glycosylation1641N-linked (GlcNAc...) Potential
Glycosylation2781N-linked (GlcNAc...) Potential
Glycosylation2891N-linked (GlcNAc...) Potential
Glycosylation3441N-linked (GlcNAc...) Potential
Glycosylation4101N-linked (GlcNAc...) Potential
Glycosylation4441N-linked (GlcNAc...) Potential
Glycosylation5151N-linked (GlcNAc...) Potential
Glycosylation5381N-linked (GlcNAc...) Potential
Glycosylation6121N-linked (GlcNAc...) Potential
Glycosylation6271N-linked (GlcNAc...) Potential
Glycosylation6951N-linked (GlcNAc...) Potential
Glycosylation7271N-linked (GlcNAc...) Potential
Glycosylation7491N-linked (GlcNAc...) Potential
Disulfide bond732 ↔ 779 By similarity
Disulfide bond746 ↔ 793 By similarity
Disulfide bond755 ↔ 809 By similarity
Disulfide bond759 ↔ 811 By similarity
Disulfide bond? ↔ 816 By similarity

Experimental info

Non-terminal residue11

Sequences

Sequence LengthMass (Da)Tools
P98089 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: 6335BCDCAC897F35

FASTA83791,500
        10         20         30         40         50         60 
VNCSVDCQLQ VFNWSCPSTP STPPPSTPTT PTSSQTTTPS TPSTTSSKST PSTPQSTSSK 

        70         80         90        100        110        120 
STPSTPPKTT LPGCLDFDPP RQVNETWWLC NCTMAICKYD NVVEIVELEC NPPPMPTCSN 

       130        140        150        160        170        180 
GLKPVRVPDP DGCCWHWECD CYCTGWGDPH FVTFDGLYYS YQGNCTYVLV EEITPTVDNF 

       190        200        210        220        230        240 
GVYIDNYHCD ANDKVSCPRT LIVHHETQEV LIKTVHMMPI EVEVQVNKQL VALPYKKYGL 

       250        260        270        280        290        300 
EVYQSGINFV VDIPRLGAQV SYNGLSFSIR LPYHLFGNNT KGQCGTCTNN TADDCILPSG 

       310        320        330        340        350        360 
EIISNCEVAA DEWLVNDPSK PHCPHKGLTT KRPAITTPGP FPENCTVSPV CQLIMDSLFS 

       370        380        390        400        410        420 
QCHPFVPPKH YYEACLFDSC FVAGSGMECA SVQAYAALCA QEGVCIDWRN HTQGACAVTC 

       430        440        450        460        470        480 
PAHRQYQACG PSEEPTCQSS SPKNSTLLVE GCFCPEGTTK FAPGYDVCVK ICGCVGPDNV 

       490        500        510        520        530        540 
PREFGEHFEF DCKDCVCLEG GSGIVCQPKK CARGNLTTCE EDGTYLVVEA DPDDKCCNTT 

       550        560        570        580        590        600 
SCKCDPKRCK AERPSCLLGF EVKSEHVPGK CCPVYSCVPK GVCVHENAEY QPGSPVYSNK 

       610        620        630        640        650        660 
CQDCVCTDSM DNSTQLNVIS CTHVPCNISC SSGFELVEVP GECCKKCQQT HCIIKRPEQQ 

       670        680        690        700        710        720 
YIILKPGEIQ KNPNDRCTFF SCMKINNQLI SSVSNITCPD FDPSDCVPGS ITYMPNGCCK 

       730        740        750        760        770        780 
TCIHNPNNTV PCSAIPVMKE ISYNGCAKNI SMNFCAGSCG TFAMYSAQAQ DLDHGCSCCR 

       790        800        810        820        830 
EERTSVRMVS LDCPDGSKLS HSYTHIESCL CQGTVCELPQ AQQSRTRRSS PRLLGRK

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References

[1]"cDNA for the carboxyl-terminal region of a rat intestinal mucin-like peptide."
Xu G., Huan L.-J., Khatri I., Wang D., Bennick A., Fahim R.E.F., Forstner G.G., Forstner J.F.
J. Biol. Chem. 267:5401-5407(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Intestine.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		M81920 mRNA. No translation available.
IPIIPI00958568.
PIRA42112.

3D structure databases

ModBaseSearch...

Proteomic databases

PRIDEP98089.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

RGD1594023. LOC682824.

Phylogenomic databases

HOVERGENHBG071087.

Gene expression databases

GenevestigatorP98089.

Family and domain databases

InterProIPR006208. Cys_knot.
IPR006207. Cys_knot_C.
IPR002919. TIL_dom.
IPR014853. Unchr_dom_Cys-rich.
IPR001007. VWF_C.
IPR001846. VWF_type-D.
[Graphical view]
PfamPF08742. C8. 1 hit.
PF00007. Cys_knot. 1 hit.
PF00094. VWD. 1 hit.
[Graphical view]
SMARTSM00832. C8. 1 hit.
SM00041. CT. 1 hit.
SM00214. VWC. 2 hits.
SM00216. VWD. 1 hit.
[Graphical view]
SUPFAMSSF57567. Cysrich_TIL. 1 hit.
PROSITEPS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS00022. EGF_1. 1 hit. Uncertain.
PS01208. VWFC_1. 2 hits.
PS50184. VWFC_2. 2 hits.
PS51233. VWFD. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMUC2L_RAT
AccessionPrimary (citable) accession number: P98089
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: April 3, 2013
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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