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P98089

- MUC2L_RAT

UniProt

P98089 - MUC2L_RAT

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Protein

Intestinal mucin-like protein

Gene
N/A
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Intestinal mucin-like protein
Short name:
MLP
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi1594023. LOC682824.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – 837›837Intestinal mucin-like proteinPRO_0000158959Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi? ↔ 816By similarity
Glycosylationi91 – 911N-linked (GlcNAc...)Sequence Analysis
Glycosylationi164 – 1641N-linked (GlcNAc...)Sequence Analysis
Glycosylationi278 – 2781N-linked (GlcNAc...)Sequence Analysis
Glycosylationi289 – 2891N-linked (GlcNAc...)Sequence Analysis
Glycosylationi344 – 3441N-linked (GlcNAc...)Sequence Analysis
Glycosylationi410 – 4101N-linked (GlcNAc...)Sequence Analysis
Glycosylationi444 – 4441N-linked (GlcNAc...)Sequence Analysis
Glycosylationi515 – 5151N-linked (GlcNAc...)Sequence Analysis
Glycosylationi538 – 5381N-linked (GlcNAc...)Sequence Analysis
Glycosylationi612 – 6121N-linked (GlcNAc...)Sequence Analysis
Glycosylationi627 – 6271N-linked (GlcNAc...)Sequence Analysis
Glycosylationi695 – 6951N-linked (GlcNAc...)Sequence Analysis
Glycosylationi727 – 7271N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi732 ↔ 779By similarity
Disulfide bondi746 ↔ 793By similarity
Glycosylationi749 – 7491N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi755 ↔ 809By similarity
Disulfide bondi759 ↔ 811By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP98089.

Expressioni

Tissue specificityi

Coats the epithelia of the intestines.

Gene expression databases

GenevestigatoriP98089.

Interactioni

Subunit structurei

Multimeric.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati17 – 27111Add
BLAST
Repeati28 – 38112Add
BLAST
Repeati39 – 50123Add
BLAST
Repeati51 – 62124Add
BLAST
Repeati63 – 7085; truncated
Domaini142 – 365224VWFDPROSITE-ProRule annotationAdd
BLAST
Domaini472 – 54372VWFC 1PROSITE-ProRule annotationAdd
BLAST
Domaini581 – 64868VWFC 2PROSITE-ProRule annotationAdd
BLAST
Domaini732 – 81786CTCKPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni17 – 70545 X 11 AA approximate tandem repeatsAdd
BLAST
Regioni149 – 837689Probably important for disulfide-bond mediated mucin polymerization (link domain)Add
BLAST

Sequence similaritiesi

Contains 1 CTCK (C-terminal cystine knot-like) domain.PROSITE-ProRule annotation
Contains 2 VWFC domains.PROSITE-ProRule annotation
Contains 1 VWFD domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

HOVERGENiHBG071087.
InParanoidiP98089.
PhylomeDBiP98089.

Family and domain databases

InterProiIPR006207. Cys_knot_C.
IPR006208. Glyco_hormone_CN.
IPR002919. TIL_dom.
IPR014853. Unchr_dom_Cys-rich.
IPR001007. VWF_C.
IPR001846. VWF_type-D.
[Graphical view]
PfamiPF08742. C8. 1 hit.
PF00007. Cys_knot. 1 hit.
PF00094. VWD. 1 hit.
[Graphical view]
SMARTiSM00832. C8. 1 hit.
SM00041. CT. 1 hit.
SM00214. VWC. 2 hits.
SM00216. VWD. 1 hit.
[Graphical view]
SUPFAMiSSF57567. SSF57567. 1 hit.
PROSITEiPS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS00022. EGF_1. 1 hit.
PS01208. VWFC_1. 2 hits.
PS50184. VWFC_2. 2 hits.
PS51233. VWFD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

P98089-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
VNCSVDCQLQ VFNWSCPSTP STPPPSTPTT PTSSQTTTPS TPSTTSSKST
60 70 80 90 100
PSTPQSTSSK STPSTPPKTT LPGCLDFDPP RQVNETWWLC NCTMAICKYD
110 120 130 140 150
NVVEIVELEC NPPPMPTCSN GLKPVRVPDP DGCCWHWECD CYCTGWGDPH
160 170 180 190 200
FVTFDGLYYS YQGNCTYVLV EEITPTVDNF GVYIDNYHCD ANDKVSCPRT
210 220 230 240 250
LIVHHETQEV LIKTVHMMPI EVEVQVNKQL VALPYKKYGL EVYQSGINFV
260 270 280 290 300
VDIPRLGAQV SYNGLSFSIR LPYHLFGNNT KGQCGTCTNN TADDCILPSG
310 320 330 340 350
EIISNCEVAA DEWLVNDPSK PHCPHKGLTT KRPAITTPGP FPENCTVSPV
360 370 380 390 400
CQLIMDSLFS QCHPFVPPKH YYEACLFDSC FVAGSGMECA SVQAYAALCA
410 420 430 440 450
QEGVCIDWRN HTQGACAVTC PAHRQYQACG PSEEPTCQSS SPKNSTLLVE
460 470 480 490 500
GCFCPEGTTK FAPGYDVCVK ICGCVGPDNV PREFGEHFEF DCKDCVCLEG
510 520 530 540 550
GSGIVCQPKK CARGNLTTCE EDGTYLVVEA DPDDKCCNTT SCKCDPKRCK
560 570 580 590 600
AERPSCLLGF EVKSEHVPGK CCPVYSCVPK GVCVHENAEY QPGSPVYSNK
610 620 630 640 650
CQDCVCTDSM DNSTQLNVIS CTHVPCNISC SSGFELVEVP GECCKKCQQT
660 670 680 690 700
HCIIKRPEQQ YIILKPGEIQ KNPNDRCTFF SCMKINNQLI SSVSNITCPD
710 720 730 740 750
FDPSDCVPGS ITYMPNGCCK TCIHNPNNTV PCSAIPVMKE ISYNGCAKNI
760 770 780 790 800
SMNFCAGSCG TFAMYSAQAQ DLDHGCSCCR EERTSVRMVS LDCPDGSKLS
810 820 830
HSYTHIESCL CQGTVCELPQ AQQSRTRRSS PRLLGRK
Length:837
Mass (Da):91,500
Last modified:February 1, 1996 - v1
Checksum:i6335BCDCAC897F35
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M81920 mRNA. No translation available.
PIRiA42112.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M81920 mRNA. No translation available.
PIRi A42112.

3D structure databases

ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P98089.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

RGDi 1594023. LOC682824.

Phylogenomic databases

HOVERGENi HBG071087.
InParanoidi P98089.
PhylomeDBi P98089.

Gene expression databases

Genevestigatori P98089.

Family and domain databases

InterProi IPR006207. Cys_knot_C.
IPR006208. Glyco_hormone_CN.
IPR002919. TIL_dom.
IPR014853. Unchr_dom_Cys-rich.
IPR001007. VWF_C.
IPR001846. VWF_type-D.
[Graphical view ]
Pfami PF08742. C8. 1 hit.
PF00007. Cys_knot. 1 hit.
PF00094. VWD. 1 hit.
[Graphical view ]
SMARTi SM00832. C8. 1 hit.
SM00041. CT. 1 hit.
SM00214. VWC. 2 hits.
SM00216. VWD. 1 hit.
[Graphical view ]
SUPFAMi SSF57567. SSF57567. 1 hit.
PROSITEi PS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS00022. EGF_1. 1 hit.
PS01208. VWFC_1. 2 hits.
PS50184. VWFC_2. 2 hits.
PS51233. VWFD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "cDNA for the carboxyl-terminal region of a rat intestinal mucin-like peptide."
    Xu G., Huan L.-J., Khatri I., Wang D., Bennick A., Fahim R.E.F., Forstner G.G., Forstner J.F.
    J. Biol. Chem. 267:5401-5407(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Intestine.

Entry informationi

Entry nameiMUC2L_RAT
AccessioniPrimary (citable) accession number: P98089
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: October 29, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3