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Protein

Intestinal mucin-like protein

Gene
N/A
Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Intestinal mucin-like protein
Short name:
MLP
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1594023. LOC682824.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000158959‹1 – 837Intestinal mucin-like proteinAdd BLAST›837

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi? ↔ 816By similarity
Glycosylationi91N-linked (GlcNAc...)Sequence analysis1
Glycosylationi164N-linked (GlcNAc...)Sequence analysis1
Glycosylationi278N-linked (GlcNAc...)Sequence analysis1
Glycosylationi289N-linked (GlcNAc...)Sequence analysis1
Glycosylationi344N-linked (GlcNAc...)Sequence analysis1
Glycosylationi410N-linked (GlcNAc...)Sequence analysis1
Glycosylationi444N-linked (GlcNAc...)Sequence analysis1
Glycosylationi515N-linked (GlcNAc...)Sequence analysis1
Glycosylationi538N-linked (GlcNAc...)Sequence analysis1
Glycosylationi612N-linked (GlcNAc...)Sequence analysis1
Glycosylationi627N-linked (GlcNAc...)Sequence analysis1
Glycosylationi695N-linked (GlcNAc...)Sequence analysis1
Glycosylationi727N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi732 ↔ 779By similarity
Disulfide bondi746 ↔ 793By similarity
Glycosylationi749N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi755 ↔ 809By similarity
Disulfide bondi759 ↔ 811By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP98089.
PRIDEiP98089.

Expressioni

Tissue specificityi

Coats the epithelia of the intestines.

Interactioni

Subunit structurei

Multimeric.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000064975.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati17 – 271Add BLAST11
Repeati28 – 382Add BLAST11
Repeati39 – 503Add BLAST12
Repeati51 – 624Add BLAST12
Repeati63 – 705; truncated8
Domaini142 – 365VWFDPROSITE-ProRule annotationAdd BLAST224
Domaini472 – 543VWFC 1PROSITE-ProRule annotationAdd BLAST72
Domaini581 – 648VWFC 2PROSITE-ProRule annotationAdd BLAST68
Domaini732 – 817CTCKPROSITE-ProRule annotationAdd BLAST86

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni17 – 705 X 11 AA approximate tandem repeatsAdd BLAST54
Regioni149 – 837Probably important for disulfide-bond mediated mucin polymerization (link domain)Add BLAST689

Sequence similaritiesi

Contains 1 CTCK (C-terminal cystine knot-like) domain.PROSITE-ProRule annotation
Contains 2 VWFC domains.PROSITE-ProRule annotation
Contains 1 VWFD domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1216. Eukaryota.
ENOG410XNSK. LUCA.
HOVERGENiHBG071087.
InParanoidiP98089.
PhylomeDBiP98089.

Family and domain databases

InterProiIPR006207. Cys_knot_C.
IPR006208. Glyco_hormone_CN.
IPR028580. MUC2.
IPR002919. TIL_dom.
IPR014853. Unchr_dom_Cys-rich.
IPR001007. VWF_dom.
IPR001846. VWF_type-D.
[Graphical view]
PANTHERiPTHR11339:SF261. PTHR11339:SF261. 1 hit.
PfamiPF08742. C8. 1 hit.
PF00007. Cys_knot. 1 hit.
PF01826. TIL. 1 hit.
PF00094. VWD. 1 hit.
[Graphical view]
SMARTiSM00832. C8. 1 hit.
SM00041. CT. 1 hit.
SM00214. VWC. 2 hits.
SM00216. VWD. 1 hit.
[Graphical view]
SUPFAMiSSF57567. SSF57567. 1 hit.
PROSITEiPS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS00022. EGF_1. 1 hit.
PS01208. VWFC_1. 2 hits.
PS50184. VWFC_2. 2 hits.
PS51233. VWFD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

P98089-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
VNCSVDCQLQ VFNWSCPSTP STPPPSTPTT PTSSQTTTPS TPSTTSSKST
60 70 80 90 100
PSTPQSTSSK STPSTPPKTT LPGCLDFDPP RQVNETWWLC NCTMAICKYD
110 120 130 140 150
NVVEIVELEC NPPPMPTCSN GLKPVRVPDP DGCCWHWECD CYCTGWGDPH
160 170 180 190 200
FVTFDGLYYS YQGNCTYVLV EEITPTVDNF GVYIDNYHCD ANDKVSCPRT
210 220 230 240 250
LIVHHETQEV LIKTVHMMPI EVEVQVNKQL VALPYKKYGL EVYQSGINFV
260 270 280 290 300
VDIPRLGAQV SYNGLSFSIR LPYHLFGNNT KGQCGTCTNN TADDCILPSG
310 320 330 340 350
EIISNCEVAA DEWLVNDPSK PHCPHKGLTT KRPAITTPGP FPENCTVSPV
360 370 380 390 400
CQLIMDSLFS QCHPFVPPKH YYEACLFDSC FVAGSGMECA SVQAYAALCA
410 420 430 440 450
QEGVCIDWRN HTQGACAVTC PAHRQYQACG PSEEPTCQSS SPKNSTLLVE
460 470 480 490 500
GCFCPEGTTK FAPGYDVCVK ICGCVGPDNV PREFGEHFEF DCKDCVCLEG
510 520 530 540 550
GSGIVCQPKK CARGNLTTCE EDGTYLVVEA DPDDKCCNTT SCKCDPKRCK
560 570 580 590 600
AERPSCLLGF EVKSEHVPGK CCPVYSCVPK GVCVHENAEY QPGSPVYSNK
610 620 630 640 650
CQDCVCTDSM DNSTQLNVIS CTHVPCNISC SSGFELVEVP GECCKKCQQT
660 670 680 690 700
HCIIKRPEQQ YIILKPGEIQ KNPNDRCTFF SCMKINNQLI SSVSNITCPD
710 720 730 740 750
FDPSDCVPGS ITYMPNGCCK TCIHNPNNTV PCSAIPVMKE ISYNGCAKNI
760 770 780 790 800
SMNFCAGSCG TFAMYSAQAQ DLDHGCSCCR EERTSVRMVS LDCPDGSKLS
810 820 830
HSYTHIESCL CQGTVCELPQ AQQSRTRRSS PRLLGRK
Length:837
Mass (Da):91,500
Last modified:February 1, 1996 - v1
Checksum:i6335BCDCAC897F35
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M81920 mRNA. No translation available.
PIRiA42112.
UniGeneiRn.217174.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M81920 mRNA. No translation available.
PIRiA42112.
UniGeneiRn.217174.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000064975.

Proteomic databases

PaxDbiP98089.
PRIDEiP98089.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

RGDi1594023. LOC682824.

Phylogenomic databases

eggNOGiKOG1216. Eukaryota.
ENOG410XNSK. LUCA.
HOVERGENiHBG071087.
InParanoidiP98089.
PhylomeDBiP98089.

Family and domain databases

InterProiIPR006207. Cys_knot_C.
IPR006208. Glyco_hormone_CN.
IPR028580. MUC2.
IPR002919. TIL_dom.
IPR014853. Unchr_dom_Cys-rich.
IPR001007. VWF_dom.
IPR001846. VWF_type-D.
[Graphical view]
PANTHERiPTHR11339:SF261. PTHR11339:SF261. 1 hit.
PfamiPF08742. C8. 1 hit.
PF00007. Cys_knot. 1 hit.
PF01826. TIL. 1 hit.
PF00094. VWD. 1 hit.
[Graphical view]
SMARTiSM00832. C8. 1 hit.
SM00041. CT. 1 hit.
SM00214. VWC. 2 hits.
SM00216. VWD. 1 hit.
[Graphical view]
SUPFAMiSSF57567. SSF57567. 1 hit.
PROSITEiPS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS00022. EGF_1. 1 hit.
PS01208. VWFC_1. 2 hits.
PS50184. VWFC_2. 2 hits.
PS51233. VWFD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMUC2L_RAT
AccessioniPrimary (citable) accession number: P98089
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 30, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.