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UniProtKB - P98088 (MUC5A_HUMAN)

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Protein

Mucin-5AC

Gene

MUC5AC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Gel-forming glycoprotein of gastric and respiratoy tract epithelia that protects the mucosa from infection and chemical damage by binding to inhaled microrganisms and particles that are subsequently removed by the mucocilary system.

GO - Molecular functioni

  • extracellular matrix structural constituent Source: UniProtKB
Complete GO annotation...

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-HSA-5083625. Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC).
R-HSA-5083632. Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS).
R-HSA-5083636. Defective GALNT12 causes colorectal cancer 1 (CRCS1).
R-HSA-5621480. Dectin-2 family.
R-HSA-913709. O-linked glycosylation of mucins.
R-HSA-977068. Termination of O-glycan biosynthesis.

Protein family/group databases

MEROPSiI08.951.

Names & Taxonomyi

Protein namesi
Recommended name:
Mucin-5ACCurated
Short name:
MUC-5ACCurated
Alternative name(s):
Gastric mucin1 Publication
Lewis B blood group antigen1 Publication
Short name:
LeB1 Publication
Major airway glycoprotein1 Publication
Mucin-5 subtype AC, tracheobronchial
Tracheobronchial mucin1 Publication
Short name:
TBM1 Publication
Gene namesi
Name:MUC5AC1 PublicationImported
Synonyms:MUC51 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:7515. MUC5AC.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • extracellular space Source: UniProtKB
  • Golgi lumen Source: Reactome
  • mucus layer Source: MGI
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi2122W → A: No binding to mannose-specific lectin. Loss of secretion from the endoplasmic reticulum. 1 Publication1
Mutagenesisi4926D → A or E: Abolishes cleavage. 1 Publication1

Organism-specific databases

DisGeNETi4586.
OpenTargetsiENSG00000215182.

Polymorphism and mutation databases

DMDMi160370004.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
ChainiPRO_000015895728 – 5654Mucin-5ACSequence analysisAdd BLAST5627

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi103 ↔ 111PROSITE-ProRule annotation
Glycosylationi205N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi258N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi415N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi456 ↔ 464PROSITE-ProRule annotation
Glycosylationi524N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1308N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1389C-linked (Man) tryptophanCurated1
Glycosylationi1584C-linked (Man) tryptophanCurated1
Glycosylationi1749C-linked (Man) tryptophanCurated1
Glycosylationi1957C-linked (Man) tryptophanCurated1
Glycosylationi2122C-linked (Man) tryptophan1 Publication1
Glycosylationi3228C-linked (Man) tryptophanCurated1
Glycosylationi3526C-linked (Man) tryptophanCurated1
Glycosylationi3774N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3959C-linked (Man) tryptophanCurated1
Glycosylationi4633C-linked (Man) tryptophanCurated1
Glycosylationi4869N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi4942N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi5057N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi5093N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi5236N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi5347N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi5377N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi5386N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi5455N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi5528N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi5532 ↔ 5582PROSITE-ProRule annotation
Disulfide bondi5546 ↔ 5596PROSITE-ProRule annotation
Disulfide bondi5557 ↔ 5612PROSITE-ProRule annotation
Disulfide bondi5561 ↔ 5614PROSITE-ProRule annotation
Glycosylationi5591N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

C-, O- and N-glycosylated. O-glycosylated on the Thr-/Ser-rich tandem repeats. C-mannosylation in the Cys-rich subdomains may be required for proper folding of these regions and for export from the endoplasmic reticulum during biosynthesis.1 Publication
Proteolytic cleavage in the C-terminal is initiated early in the secretory pathway and does not involve a serine protease. The extent of cleavage is increased in the acidic parts of the secretory pathway. Cleavage generates a reactive group which could link the protein to a primary amide.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei4926 – 4927Cleavage2

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PeptideAtlasiP98088.
PRIDEiP98088.

PTM databases

iPTMnetiP98088.
UniCarbKBiP98088.

Expressioni

Tissue specificityi

Highly expressed in surface mucosal cells of respiratory tract and stomach epithelia. Overexpressed in a number of carcinomas. Also expressed in Barrett's esophagus epithelium and in the proximal duodenum.2 Publications

Gene expression databases

GenevisibleiP98088. HS.

Organism-specific databases

HPAiCAB002774.
CAB009395.
HPA040456.
HPA040615.

Interactioni

Subunit structurei

Multimeric. Interacts with H.pylori in the gastric epithelium, Barrett's esophagus as well as in gastric metaplasia of the duodenum (GMD).1 Publication

Protein-protein interaction databases

IntActiP98088. 1 interactor.
STRINGi9606.ENSP00000435591.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5AJNX-ray1.67P4254-4268[»]
5AJOX-ray1.48B2528-2543[»]
5AJPX-ray1.65B2528-2543[»]
ProteinModelPortaliP98088.
SMRiP98088.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini80 – 281VWFD 1PROSITE-ProRule annotationAdd BLAST202
Domaini338 – 394TIL 1Sequence analysisAdd BLAST57
Domaini394 – 465VWFC 1PROSITE-ProRule annotationAdd BLAST72
Domaini433 – 647VWFD 2PROSITE-ProRule annotationAdd BLAST215
Domaini704 – 761TIL 2Sequence analysisAdd BLAST58
Domaini818 – 863TIL 3Sequence analysisAdd BLAST46
Domaini902 – 1109VWFD 3PROSITE-ProRule annotationAdd BLAST208
Repeati1383 – 1481Cys-rich subdomain 1Add BLAST99
Repeati1577 – 1677Cys-rich subdomain 2Add BLAST101
Repeati1743 – 1847Cys-rich subdomain 3Add BLAST105
Repeati1950 – 2050Cys-rich subdomain 4Add BLAST101
Repeati2116 – 2220Cys-rich subdomain 5Add BLAST105
Repeati3222 – 3326Cys-rich subdomain 6Add BLAST105
Repeati3520 – 3660Cys-rich subdomain 7Add BLAST141
Repeati3953 – 4057Cys-rich subdomain 8Add BLAST105
Repeati4627 – 4731Cys-rich subdomain 9Add BLAST105
Domaini4852 – 4918VWFC 2PROSITE-ProRule annotationAdd BLAST67
Domaini4920 – 5131VWFD 4PROSITE-ProRule annotationAdd BLAST212
Domaini5276 – 5345VWFC 3PROSITE-ProRule annotationAdd BLAST70
Domaini5381 – 5448VWFC 4PROSITE-ProRule annotationAdd BLAST68
Domaini5532 – 5620CTCKPROSITE-ProRule annotationAdd BLAST89

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1383 – 47319 X Cys-rich subdomain repeatsAdd BLAST3349
Regioni2257 – 3200107 X 8 AA approximate tandem repeats of T-T-S-T-T-S-A-PAdd BLAST944
Regioni3363 – 349817 X 8 AA approximate tandem repeats of T-T-S-T-T-S-A-PAdd BLAST136
Regioni3661 – 393134 X 8 AA approximate tandem repeats of T-T-S-T-T-S-A-PAdd BLAST271
Regioni4093 – 459558 X 8 AA approximate tandem repeats of T-T-S-T-T-S-A-PAdd BLAST503

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1490 – 1585Thr-richPROSITE-ProRule annotationAdd BLAST96
Compositional biasi1681 – 1750Thr-richPROSITE-ProRule annotationAdd BLAST70
Compositional biasi1850 – 1958Thr-richPROSITE-ProRule annotationAdd BLAST109
Compositional biasi2054 – 2124Thr-richPROSITE-ProRule annotationAdd BLAST71
Compositional biasi2223 – 4618Thr-richPROSITE-ProRule annotationAdd BLAST2396
Compositional biasi2231 – 4615Ser-richPROSITE-ProRule annotationAdd BLAST2385
Compositional biasi4750 – 4778Ser-richPROSITE-ProRule annotationAdd BLAST29
Compositional biasi5520 – 5525Poly-ProSequence analysis6

Domaini

The cysteine residues in the Cys-rich subdomain repeats are not involved in disulfide bonding.

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

GeneTreeiENSGT00760000118896.
InParanoidiP98088.
KOiK21125.
OMAiCSNEDNA.
OrthoDBiEOG091G0006.

Family and domain databases

InterProiView protein in InterPro
IPR006207. Cys_knot_C.
IPR028580. MUC2.
IPR002919. TIL_dom.
IPR014853. Unchr_dom_Cys-rich.
IPR001007. VWF_dom.
IPR001846. VWF_type-D.
IPR025155. WxxW_domain.
PANTHERiPTHR11339:SF345. PTHR11339:SF345. 1 hit.
PfamiView protein in Pfam
PF08742. C8. 4 hits.
PF13330. Mucin2_WxxW. 9 hits.
PF01826. TIL. 3 hits.
PF00094. VWD. 4 hits.
SMARTiView protein in SMART
SM00832. C8. 4 hits.
SM00041. CT. 1 hit.
SM00214. VWC. 6 hits.
SM00215. VWC_out. 2 hits.
SM00216. VWD. 4 hits.
SUPFAMiSSF57567. SSF57567. 4 hits.
PROSITEiView protein in PROSITE
PS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS01208. VWFC_1. 2 hits.
PS50184. VWFC_2. 2 hits.
PS51233. VWFD. 4 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P98088-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVGRRKLAL LWALALALAC TRHTGHAQDG SSESSYKHHP ALSPIARGPS 
        60         70         80         90        100
GVPLRGATVF PSLRTIPVVR ASNPAHNGRV CSTWGSFHYK TFDGDVFRFP 
       110        120        130        140        150
GLCNYVFSEH CGAAYEDFNI QLRRSQESAA PTLSRVLMKV DGVVIQLTKG 
       160        170        180        190        200
SVLVNGHPVL LPFSQSGVLI QQSSSYTKVE ARLGLVLMWN HDDSLLLELD 
       210        220        230        240        250
TKYANKTCGL CGDFNGMPVV SELLSHNTKL TPMEFGNLQK MDDPTDQCQD 
       260        270        280        290        300
PVPEPPRNCS TGFGICEELL HGQLFSGCVA LVDVGSYLEA CRQDLCFCED 
       310        320        330        340        350
TDLLSCVCHT LAEYSRQCTH AGGLPQDWRG PDFCPQKCPN NMQYHECRSP 
       360        370        380        390        400
CADTCSNQEH SRACEDHCVA GCFCPEGTVL DDIGQTGCVP VSKCACVYNG 
       410        420        430        440        450
AAYAPGATYS TDCTNCTCSG GRWSCQEVPC PGTCSVLGGA HFSTFDGKQY 
       460        470        480        490        500
TVHGDCSYVL TKPCDSSAFT VLAELRRCGL TDSETCLKSV TLSLDGAQTV 
       510        520        530        540        550
VVIKASGEVF LNQIYTQLPI SAANVTIFRP STFFIIAQTS LGLQLNLQLV 
       560        570        580        590        600
PTMQLFMQLA PKLRGQTCGL CGNFNSIQAD DFRTLSGVVE ATAAAFFNTF 
       610        620        630        640        650
KTQAACPNIR NSFEDPCSLS VENEKYAQHW CSQLTDADGP FGRCHAAVKP 
       660        670        680        690        700
GTYYSNCMFD TCNCERSEDC LCAALSSYVH ACAAKGVQLG GWRDGVCTKP 
       710        720        730        740        750
MTTCPKSMTY HYHVSTCQPT CRSLSEGDIT CSVGFIPVDG CICPKGTFLD 
       760        770        780        790        800
DTGKCVQASN CPCYHRGSMI PNGESVHDSG AICTCTHGKL SCIGGQAPAP 
       810        820        830        840        850
VCAAPMVFFD CRNATPGDTG AGCQKSCHTL DMTCYSPQCV PGCVCPDGLV 
       860        870        880        890        900
ADGEGGCITA EDCPCVHNEA SYRAGQTIRV GCNTCTCDSR MWRCTDDPCL 
       910        920        930        940        950
ATCAVYGDGH YLTFDGQSYS FNGDCEYTLV QNHCGGKDST QDSFRVVTEN 
       960        970        980        990       1000
VPCGTTGTTC SKAIKIFLGG FELKLSHGKV EVIGTDESQE VPYTIRQMGI 
      1010       1020       1030       1040       1050
YLVVDTDIGL VLLWDKKTSI FINLSPEFKG RVCGLCGNFD DIAVNDFATR 
      1060       1070       1080       1090       1100
SRSVVGDVLE FGNSWKLSPS CPDALAPKDP CTANPFRKSW AQKQCSILHG 
      1110       1120       1130       1140       1150
PTFAACHAHV EPARYYEACV NDACACDSGG DCECFCTAVA AYAQACHEVG 
      1160       1170       1180       1190       1200
LCVSWRTPSI CPLFCDYYNP EGQCEWHYQP CGVPCLRTCR NPRGDCLRDV 
      1210       1220       1230       1240       1250
RGLEGCYPKC PPEAPIFDED KMQCVATCPT PPLPPRCHVH GKSYRPGAVV 
      1260       1270       1280       1290       1300
PSDKNCQSCL CTERGVECTY KAEACVCTYN GQRFHPGDVI YHTTDGTGGC 
      1310       1320       1330       1340       1350
ISARCGANGT IERRVYPCSP TTPVPPTTFS FSTPPLVVSS THTPSNGPSS 
      1360       1370       1380       1390       1400
AHTGPPSSAW PTTAGTSPRT RLPTASASLP PVCGEKCLWS PWMDVSRPGR 
      1410       1420       1430       1440       1450
GTDSGDFDTL ENLRAHGYRV CESPRSVECR AEDAPGVPLR ALGQRVQCSP 
      1460       1470       1480       1490       1500
DVGLTCRNRE QASGLCYNYQ IRVQCCTPLP CSTSSSPAQT TPPTTSKTTE 
      1510       1520       1530       1540       1550
TRASGSSAPS STPGTVSLST ARTTPAPGTA TSVKKTFSTP SPPPVPATST 
      1560       1570       1580       1590       1600
SSMSTTAPGT SVVSSKPTPT EPSTSSCLQE LCTWTEWIDG SYPAPGINGG 
      1610       1620       1630       1640       1650
DFDTFQNLRD EGYTFCESPR SVQCRAESFP NTPLADLGQD VICSHTEGLI 
      1660       1670       1680       1690       1700
CLNKNQLPPI CYNYEIRIQC CETVNVCRDI TRLPKTVATT RPTPHPTGAQ 
      1710       1720       1730       1740       1750
TQTTFTTHMP SASTEQPTAT SRGGPTATSV TQGTHTTLVT RNCHPRCTWT 
      1760       1770       1780       1790       1800
KWFDVDFPSP GPHGGDKETY NNIIRSGEKI CRRPEEITRL QCRAKSHPEV 
      1810       1820       1830       1840       1850
SIEHLGQVVQ CSREEGLVCR NQDQQGPFKM CLNYEVRVLC CETPRGCHMT 
      1860       1870       1880       1890       1900
STPGSTSSSP AQTTPSTTSK TTETQASGSS APSSTPGTVS LSTARTTPAP 
      1910       1920       1930       1940       1950
GTATSVKKTF STPSPPPVPA TSTSSMSTTA PGTSVVSSKP TPTEPSTSSC 
      1960       1970       1980       1990       2000
LQELCTWTEW IDGSYPAPGI NGGDFDTFQN LRDEGYTFCE SPRSVQCRAE 
      2010       2020       2030       2040       2050
SFPNTPLADL GQDVICSHTE GLICLNKNQL PPICYNYEIR IQCCETVNVC 
      2060       2070       2080       2090       2100
RDITRPPKTV ATTRPTPHPT GAQTQTTFTT HMPSASTEQP TATSRGGPTA 
      2110       2120       2130       2140       2150
TSVTQGTHTT PVTRNCHPRC TWTTWFDVDF PSPGPHGGDK ETYNNIIRSG 
      2160       2170       2180       2190       2200
EKICRRPEEI TRLQCRAKSH PEVSIEHLGQ VVQCSREEGL VCRNQDQQGP 
      2210       2220       2230       2240       2250
FKMCLNYEVR VLCCETPKGC PVTSTPVTAP STPSGRATSP TQSTSSWQKS 
      2260       2270       2280       2290       2300
RTTTLVTTST TSTPQTSTTY AHTTSTTSAP TARTTSAPTT RTTSASPAST 
      2310       2320       2330       2340       2350
TSGPGNTPSP VPTTSTISAP TTSITSAPTT STTSAPTSST TSGPGTTPSP 
      2360       2370       2380       2390       2400
VPTTSITSAP TTSTTSAPTT STTSARTSST TSATTTSRIS GPETTPSPVP 
      2410       2420       2430       2440       2450
TTSTTSATTT STTSAPTTST TSAPTSSTTS SPQTSTTSAP TTSTTSGPGT 
      2460       2470       2480       2490       2500
TPSPVPTTST TSAPTTRTTS APKSSTTSAA TTSTTSGPET TPRPVPTTST 
      2510       2520       2530       2540       2550
TSSPTTSTTS APTTSTTSAS TTSTTSGAGT TPSPVPTTST TSAPTTSTTS 
      2560       2570       2580       2590       2600
APISSTTSAT TTSTTSGPGT TPSPVPTTST TSAPTTSTTS GPGTTPSAVP 
      2610       2620       2630       2640       2650
TTSITSAPTT STNSAPISST TSATTTSRIS GPETTPSPVP TASTTSASTT 
      2660       2670       2680       2690       2700
STTSGPGTTP SPVPTTSTIS VPTTSTTSAS TTSTTSASTT STTSGPGTTP 
      2710       2720       2730       2740       2750
SPVPTTSTTS APTTSTTSAP TTSTISAPTT STTSATTTST TSAPTPRRTS 
      2760       2770       2780       2790       2800
APTTSTISAS TTSTTSATTT STTSATTTST ISAPTTSTTL SPTTSTTSTT 
      2810       2820       2830       2840       2850
ITSTTSAPIS STTSTPQTST TSAPTTSTTS GPGTTSSPVP TTSTTSAPTT 
      2860       2870       2880       2890       2900
STTSAPTTRT TSVPTSSTTS TATTSTTSGP GTTPSPVPTT STTSAPTTRT 
      2910       2920       2930       2940       2950
TSAPTTSTTS APTTSTTSAP TSSTTSATTT STISVPTTST TSVPGTTPSP 
      2960       2970       2980       2990       3000
VPTTSTISVP TTSTTSASTT STTSGPGTTP SPVPTTSTTS APTTSTTSAP 
      3010       3020       3030       3040       3050
TTSTISAPTT STPSAPTTST TLAPTTSTTS APTTSTTSTP TSSTTSSPQT 
      3060       3070       3080       3090       3100
STTSASTTSI TSGPGTTPSP VPTTSTTSAP TTSTTSAATT STISAPTTST 
      3110       3120       3130       3140       3150
TSAPTTSTTS ASTASKTSGL GTTPSPIPTT STTSPPTTST TSASTASKTS 
      3160       3170       3180       3190       3200
GPGTTPSPVP TTSTIFAPRT STTSASTTST TPGPGTTPSP VPTTSTASVS 
      3210       3220       3230       3240       3250
KTSTSHVSIS KTTHSQPVTR DCHLRCTWTK WFDIDFPSPG PHGGDKETYN 
      3260       3270       3280       3290       3300
NIIRSGEKIC RRPEEITRLQ CRAESHPEVS IEHLGQVVQC SREEGLVCRN 
      3310       3320       3330       3340       3350
QDQQGPFKMC LNYEVRVLCC ETPKGCPVTS TPVTAPSTPS GRATSPTQST 
      3360       3370       3380       3390       3400
SSWQKSRTTT LVTTSTTSTP QTSTTSAPTT STTSAPTTST TSAPTTSTTS 
      3410       3420       3430       3440       3450
TPQTSISSAP TSSTTSAPTS STISARTTSI ISAPTTSTTS SPTTSTTSAT 
      3460       3470       3480       3490       3500
TTSTTSAPTS STTSTPQTSK TSAATSSTTS GSGTTPSPVT TTSTASVSKT 
      3510       3520       3530       3540       3550
STSHVSVSKT THSQPVTRDC HPRCTWTKWF DVDFPSPGPH GGDKETYNNI 
      3560       3570       3580       3590       3600
IRSGEKICRR PEEITRLQCR AKSHPEVSIE HLGQVVQCSR EEGLVCRNQD 
      3610       3620       3630       3640       3650
QQGPFKMCLN YEVRVLCCET PKGCPVTSTS VTAPSTPSGR ATSPTQSTSS 
      3660       3670       3680       3690       3700
WQKSRTTTLV TSSITSTTQT STTSAPTTST TPASIPSTTS APTTSTTSAP 
      3710       3720       3730       3740       3750
TTSTTSAPTT STTSTPQTTT SSAPTSSTTS APTTSTISAP TTSTISAPTT 
      3760       3770       3780       3790       3800
STTSAPTAST TSAPTSTSSA PTTNTTSAPT TSTTSAPITS TISAPTTSTT 
      3810       3820       3830       3840       3850
STPQTSTISS PTTSTTSTPQ TSTTSSPTTS TTSAPTTSTT SAPTTSTTST 
      3860       3870       3880       3890       3900
PQTSISSAPT SSTTSAPTAS TISAPTTSTT SFHTTSTTSP PTSSTSSTPQ 
      3910       3920       3930       3940       3950
TSKTSAATSS TTSGSGTTPS PVPTTSTASV SKTSTSHVSV SKTTHSQPVT 
      3960       3970       3980       3990       4000
RDCHPRCTWT KWFDVDFPSP GPHGGDKETY NNIIRSGEKI CRRPEEITRL 
      4010       4020       4030       4040       4050
QCRAESHPEV SIEHLGQVVQ CSREEGLVCR NQDQQGPFKM CLNYEVRVLC 
      4060       4070       4080       4090       4100
CETPKGCPVT STPVTAPSTP SGRATSPTQS TSSWQKSRTT TLVTTSTTST 
      4110       4120       4130       4140       4150
PQTSTTSAPT TSTIPASTPS TTSAPTTSTT SAPTTSTTSA PTHRTTSGPT 
      4160       4170       4180       4190       4200
TSTTLAPTTS TTSAPTTSTN SAPTTSTISA STTSTISAPT TSTISSPTSS 
      4210       4220       4230       4240       4250
TTSTPQTSKT SAATSSTTSG SGTTPSPVPT TSTTSASTTS TTSAPTTSTT 
      4260       4270       4280       4290       4300
SGPGTTPSPV PSTSTTSAAT TSTTSAPTTR TTSAPTSSMT SGPGTTPSPV 
      4310       4320       4330       4340       4350
PTTSTTSAPT TSTTSGPGTT PSPVPTTSTT SAPITSTTSG PGSTPSPVPT 
      4360       4370       4380       4390       4400
TSTTSAPTTS TTSASTASTT SGPGTTPSPV PTTSTTSAPT TRTTSASTAS 
      4410       4420       4430       4440       4450
TTSGPGSTPS PVPTTSTTSA PTTRTTPAST ASTTSGPGTT PSPVPTTSTT 
      4460       4470       4480       4490       4500
SASTTSTISL PTTSTTSAPI TSMTSGPGTT PSPVPTTSTT SAPTTSTTSA 
      4510       4520       4530       4540       4550
STASTTSGPG TTPSPVPTTS TTSAPTTSTT SASTASTTSG PGTSLSPVPT 
      4560       4570       4580       4590       4600
TSTTSAPTTS TTSGPGTTPS PVPTTSTTSA PTTSTTSGPG TTPSPVPTTS 
      4610       4620       4630       4640       4650
TTPVSKTSTS HLSVSKTTHS QPVTSDCHPL CAWTKWFDVD FPSPGPHGGD 
      4660       4670       4680       4690       4700
KETYNNIIRS GEKICRRPEE ITRLQCRAES HPEVNIEHLG QVVQCSREEG 
      4710       4720       4730       4740       4750
LVCRNQDQQG PFKMCLNYEV RVLCCETPRG CPVTSVTPYG TSPTNALYPS 
      4760       4770       4780       4790       4800
LSTSMVSASV ASTSVASSSV ASSSVAYSTQ TCFCNVADRL YPAGSTIYRH 
      4810       4820       4830       4840       4850
RDLAGHCYYA LCSQDCQVVR GVDSDCPSTT LPPAPATSPS ISTSEPVTEL 
      4860       4870       4880       4890       4900
GCPNAVPPRK KGETWATPNC SEATCEGNNV ISLRPRTCPR VEKPTCANGY 
      4910       4920       4930       4940       4950
PAVKVADQDG CCHHYQCQCV CSGWGDPHYI TFDGTYYTFL DNCTYVLVQQ 
      4960       4970       4980       4990       5000
IVPVYGHFRV LVDNYFCGAE DGLSCPRSII LEYHQDRVVL TRKPVHGVMT 
      5010       5020       5030       5040       5050
NEIIFNNKVV SPGFRKNGIV VSRIGVKMYA TIPELGVQVM FSGLIFSVEV 
      5060       5070       5080       5090       5100
PFSKFANNTE GQCGTCTNDR KDECRTPRGT VVASCSEMSG LWNVSIPDQP 
      5110       5120       5130       5140       5150
ACHRPHPTPT TVGPTTVGST TVGPTTVGST TVGPTTPPAP CLPSPICQLI 
      5160       5170       5180       5190       5200
LSKVFEPCHT VIPPLLFYEG CVFDRCHMTD LDVVCSSLEL YAALCASHDI 
      5210       5220       5230       5240       5250
CIDWRGRTGH MCPFTCPADK VYQPCGPSNP SYCYGNDSAS LGALPEAGPI 
      5260       5270       5280       5290       5300
TEGCFCPEGM TLFSTSAQVC VPTGCPRCLG PHGEPVKVGH TVGMDCQECT 
      5310       5320       5330       5340       5350
CEAATWTLTC RPKLCPLPPA CPLPGFVPVP AAPQAGQCCP QYSCACNTSR 
      5360       5370       5380       5390       5400
CPAPVGCPEG ARAIPTYQEG ACCPVQNCSW TVCSINGTLY QPGAVVSSSL 
      5410       5420       5430       5440       5450
CETCRCELPG GPPSDAFVVS CETQICNTHC PVGFEYQEQS GQCCGTCVQV 
      5460       5470       5480       5490       5500
ACVTNTSKSP AHLFYPGETW SDAGNHCVTH QCEKHQDGLV VVTTKKACPP 
      5510       5520       5530       5540       5550
LSCSLDEARM SKDGCCRFCP PPPPPYQNQS TCAVYHRSLI IQQQGCSSSE 
      5560       5570       5580       5590       5600
PVRLAYCRGN CGDSSSMYSL EGNTVEHRCQ CCQELRTSLR NVTLHCTDGS 
      5610       5620       5630       5640       5650
SRAFSYTEVE ECGCMGRRCP APGDTQHSEE AEPEPSQEAE SGSWERGVPV 

SPMH
Length:5,654
Mass (Da):585,570
Last modified:April 1, 2015 - v4
Checksum:i13217A8257E8E2DE
GO

Sequence cautioni

The sequence AAA18431 differs from that shown. Reason: Frameshift at several positions.Curated
The sequence AAA18431 differs from that shown. Reason: Erroneous termination at position 4999. Translated as Met.Curated
The sequence AAC15950 differs from that shown. Reason: Frameshift at positions 24, 44, 671 and 683.Curated
The sequence CAA88307 differs from that shown. Reason: Frameshift at position 5649.Curated
The sequence CAH56330 differs from that shown. Reason: Frameshift at positions 5240, 5247 and 5253.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti25G → S in AAC15950 (PubMed:9506983).Curated1
Sequence conflicti221S → R in AAC15950 (PubMed:9506983).Curated1
Sequence conflicti246D → E in CAC83674 (PubMed:11535137).Curated1
Sequence conflicti246D → E in AAC15950 (PubMed:9506983).Curated1
Sequence conflicti432G → D in CAC83674 (PubMed:11535137).Curated1
Sequence conflicti549L → P in CAC83674 (PubMed:11535137).Curated1
Sequence conflicti658M → V in CAC83674 (PubMed:11535137).Curated1
Sequence conflicti702T → I in AAC15950 (PubMed:9506983).Curated1
Sequence conflicti716T → A in AAC15950 (PubMed:9506983).Curated1
Sequence conflicti817 – 818GD → RG in AAC15950 (PubMed:9506983).Curated2
Sequence conflicti869E → K in AAC15950 (PubMed:9506983).Curated1
Sequence conflicti978G → R in AAC15950 (PubMed:9506983).Curated1
Sequence conflicti996R → Q in CAC83674 (PubMed:11535137).Curated1
Sequence conflicti1141A → R in CAA57309 (PubMed:8948439).Curated1
Sequence conflicti1151 – 1155LCVSW → TCVCL in CAA57309 (PubMed:8948439).Curated5
Sequence conflicti1154 – 1155SW → CL in CAC83674 (PubMed:11535137).Curated2
Sequence conflicti1480P → A in CAA57309 (PubMed:8948439).Curated1
Sequence conflicti1683L → P in CAA57309 (PubMed:8948439).Curated1
Sequence conflicti1738L → P in CAA57309 (PubMed:8948439).Curated1
Sequence conflicti1790L → V in CAC83674 (PubMed:11535137).Curated1
Sequence conflicti1790L → V in CAA57309 (PubMed:8948439).Curated1
Sequence conflicti1803E → N AA sequence (PubMed:2656675).Curated1
Sequence conflicti1874T → I in CAC83674 (PubMed:11535137).Curated1
Sequence conflicti2008 – 2009AD → GR in CAC83674 (PubMed:11535137).Curated2
Sequence conflicti2176E → N AA sequence (PubMed:2656675).Curated1
Sequence conflicti2207Y → I in CAC83674 (PubMed:11535137).Curated1
Sequence conflicti2238T → I in CAC83674 (PubMed:11535137).Curated1
Sequence conflicti2289 – 4237Missing in CAC83674 (PubMed:11535137).CuratedAdd BLAST1949
Sequence conflicti3047S → T in CAC83675 (PubMed:11535137).Curated1
Sequence conflicti3088A → S in CAC83676 (PubMed:11535137).Curated1
Sequence conflicti3095 – 3096AP → PL in CAC83676 (PubMed:11535137).Curated2
Sequence conflicti3105T → I in CAC83676 (PubMed:11535137).Curated1
Sequence conflicti3107 – 4287Missing in CAC83676 (PubMed:11535137).CuratedAdd BLAST1181
Sequence conflicti3234I → V in CAC83675 (PubMed:11535137).Curated1
Sequence conflicti3481G → S in CAC83675 (PubMed:11535137).Curated1
Sequence conflicti3562E → Q in CAC83675 (PubMed:11535137).Curated1
Sequence conflicti3580E → N AA sequence (PubMed:2656675).Curated1
Sequence conflicti3636 – 3644TPSGRATSP → PLVGEPPAQ in CAC83675 (PubMed:11535137).Curated9
Sequence conflicti3817S → P in CAC83675 (PubMed:11535137).Curated1
Sequence conflicti4244A → V in CAC83674 (PubMed:11535137).Curated1
Sequence conflicti4250 – 4254TSGPG → ISGPK in CAC83674 (PubMed:11535137).Curated5
Sequence conflicti4262S → T in CAC83674 (PubMed:11535137).Curated1
Sequence conflicti4265T → I in CAC83675 (PubMed:11535137).Curated1
Sequence conflicti4274T → I in CAC83674 (PubMed:11535137).Curated1
Sequence conflicti4280 – 4284RTTSA → STTSV in CAC83674 (PubMed:11535137).Curated5
Sequence conflicti4286 – 4373Missing in CAC83674 (PubMed:11535137).CuratedAdd BLAST88
Sequence conflicti4290T → P in CAC83676 (PubMed:11535137).Curated1
Sequence conflicti4314 – 4473Missing in CAC83676 (PubMed:11535137).CuratedAdd BLAST160
Sequence conflicti4381P → L in CAC83674 (PubMed:11535137).Curated1
Sequence conflicti4398 – 4400TAS → PAG in CAC83674 (PubMed:11535137).Curated3
Sequence conflicti4407S → N in CAC83674 (PubMed:11535137).Curated1
Sequence conflicti4418T → I in CAC83674 (PubMed:11535137).Curated1
Sequence conflicti4421 – 4484Missing in CAC83674 (PubMed:11535137).CuratedAdd BLAST64
Sequence conflicti4489T → I in CAC83674 (PubMed:11535137).Curated1
Sequence conflicti4501 – 4503STA → PTS in CAC83674 (PubMed:11535137).Curated3
Sequence conflicti4521T → I in CAC83674 (PubMed:11535137).Curated1
Sequence conflicti4533 – 4572Missing in CAC83674 (PubMed:11535137).CuratedAdd BLAST40
Sequence conflicti4588G → A in CAC83674 (PubMed:11535137).Curated1
Sequence conflicti4614 – 4615VS → HE in AAA18431 (PubMed:7513696).Curated2
Sequence conflicti4827P → R in CAA88307 (PubMed:7775418).Curated1
Sequence conflicti4884R → S in CAA04737 (PubMed:9620876).Curated1
Sequence conflicti4884R → S in CAA04738 (PubMed:9620876).Curated1
Sequence conflicti4884R → S in CAA88307 (PubMed:7775418).Curated1
Sequence conflicti4886R → P in AAA18431 (PubMed:7513696).Curated1
Sequence conflicti4899G → A in AAA18431 (PubMed:7513696).Curated1
Sequence conflicti4946 – 4947VL → AW in AAA18431 (PubMed:7513696).Curated2
Sequence conflicti5013G → A in CAA88307 (PubMed:7775418).Curated1
Sequence conflicti5081 – 5084VVAS → HASA in AAH33831 (PubMed:15489334).Curated4
Sequence conflicti5148Q → H in CAA88307 (PubMed:7775418).Curated1
Sequence conflicti5148Q → H in AAA18431 (PubMed:7513696).Curated1
Sequence conflicti5209 – 5210GH → RD in AAA18431 (PubMed:7513696).Curated2
Sequence conflicti5245P → R in CAA04737 (PubMed:9620876).Curated1
Sequence conflicti5245P → R in CAA04738 (PubMed:9620876).Curated1
Sequence conflicti5245P → R in AAA18431 (PubMed:7513696).Curated1
Sequence conflicti5264S → T in CAA04737 (PubMed:9620876).Curated1
Sequence conflicti5264S → T in CAA04738 (PubMed:9620876).Curated1
Sequence conflicti5356G → R in AAA18431 (PubMed:7513696).Curated1
Sequence conflicti5363A → R in AAA18431 (PubMed:7513696).Curated1
Sequence conflicti5433G → R in AAA18431 (PubMed:7513696).Curated1
Sequence conflicti5441G → A in AAA18431 (PubMed:7513696).Curated1
Sequence conflicti5546C → S in AAA18431 (PubMed:7513696).Curated1
Sequence conflicti5622P → A in AAA18431 (PubMed:7513696).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0368325521P → L2 PublicationsCorresponds to variant dbSNP:rs1132436Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO680660 Genomic DNA. No translation available.
FP326773 Genomic DNA. No translation available.
KC800812 Genomic DNA. No translation available.
AJ298317 mRNA. Translation: CAC83674.1.
AJ298318 Genomic DNA. Translation: CAC83675.1.
AJ298319 Genomic DNA. Translation: CAC83676.1.
AF015521 mRNA. Translation: AAC15950.1. Frameshift.
X81649 mRNA. Translation: CAA57309.1.
AJ001402 mRNA. Translation: CAA04737.1.
AJ001403 Genomic DNA. Translation: CAA04738.1.
U06711 mRNA. Translation: AAA18431.1. Sequence problems.
Z48314 mRNA. Translation: CAA88307.1. Frameshift.
BC033831 mRNA. Translation: AAH33831.1.
AL833060 mRNA. Translation: CAH56330.1. Frameshift.
CCDSiCCDS76369.1.
PIRiA33811.
JE0095.
RefSeqiNP_001291288.1. NM_001304359.1.
UniGeneiHs.534332.
Hs.558950.
Hs.703588.
Hs.703728.
Hs.721515.

Genome annotation databases

EnsembliENST00000621226; ENSP00000485659; ENSG00000215182.
ENST00000636567; ENSP00000490794; ENSG00000283158.
GeneIDi4586.
KEGGihsa:4586.
UCSCiuc031xcx.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiMUC5A_HUMAN
AccessioniPrimary (citable) accession number: P98088
Secondary accession number(s): A0A096LPK4
, O60460, O76065, Q13792, Q14425, Q658Q1, Q7M4S5, Q8N4M9, Q8WWQ3, Q8WWQ4, Q8WWQ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: April 1, 2015
Last modified: July 5, 2017
This is version 156 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references