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P98088

- MUC5A_HUMAN

UniProt

P98088 - MUC5A_HUMAN

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Protein
Mucin-5AC
Gene
MUC5AC, MUC5
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Gel-forming glycoprotein of gastric and respiratoy tract epithelia that protects the mucosa from infection and chemical damage by binding to inhaled microrganisms and particles that are subsequently removed by the mucocilary system.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei4302 – 43032Cleavage

GO - Molecular functioni

  1. extracellular matrix structural constituent Source: UniProtKB

GO - Biological processi

  1. O-glycan processing Source: Reactome
  2. cellular protein metabolic process Source: Reactome
  3. extracellular fibril organization Source: MGI
  4. post-translational protein modification Source: Reactome
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_115606. O-linked glycosylation of mucins.
REACT_115835. Termination of O-glycan biosynthesis.

Protein family/group databases

MEROPSiI08.951.

Names & Taxonomyi

Protein namesi
Recommended name:
Mucin-5AC
Short name:
MUC-5AC
Alternative name(s):
Gastric mucin
Lewis B blood group antigen
Short name:
LeB
Major airway glycoprotein
Mucin-5 subtype AC, tracheobronchial
Tracheobronchial mucin
Short name:
TBM
Gene namesi
Name:MUC5AC
Synonyms:MUC5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:7515. MUC5AC.

Subcellular locationi

Secreted 1 Publication

GO - Cellular componenti

  1. Golgi lumen Source: Reactome
  2. extracellular vesicular exosome Source: UniProt
  3. fibril Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi2122 – 21221W → A: No binding to mannose-specific lectin. Loss of secretion from the endoplasmic reticulum. 1 Publication
Mutagenesisi4302 – 43021D → A or E: Abolishes cleavage. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727 Reviewed prediction
Add
BLAST
Chaini28 – 50305003Mucin-5AC
PRO_0000158957Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi? ↔ 4995 By similarity
Disulfide bondi103 ↔ 111 By similarity
Glycosylationi205 – 2051N-linked (GlcNAc...) Reviewed prediction
Glycosylationi258 – 2581N-linked (GlcNAc...) Reviewed prediction
Glycosylationi415 – 4151N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi456 ↔ 464 By similarity
Glycosylationi524 – 5241N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1308 – 13081N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1389 – 13891C-linked (Man) Inferred
Glycosylationi1584 – 15841C-linked (Man) Inferred
Glycosylationi1749 – 17491C-linked (Man) Inferred
Glycosylationi1957 – 19571C-linked (Man) Inferred
Glycosylationi2122 – 21221C-linked (Man)1 Publication
Glycosylationi2652 – 26521C-linked (Man) Inferred
Glycosylationi2950 – 29501C-linked (Man) Inferred
Glycosylationi3198 – 31981N-linked (GlcNAc...) Reviewed prediction
Glycosylationi3383 – 33831C-linked (Man) Inferred
Glycosylationi4009 – 40091C-linked (Man) Inferred
Glycosylationi4245 – 42451N-linked (GlcNAc...) Reviewed prediction
Glycosylationi4318 – 43181N-linked (GlcNAc...) Reviewed prediction
Glycosylationi4433 – 44331N-linked (GlcNAc...) Reviewed prediction
Glycosylationi4469 – 44691N-linked (GlcNAc...) Reviewed prediction
Glycosylationi4612 – 46121N-linked (GlcNAc...) Reviewed prediction
Glycosylationi4723 – 47231N-linked (GlcNAc...) Reviewed prediction
Glycosylationi4753 – 47531N-linked (GlcNAc...) Reviewed prediction
Glycosylationi4762 – 47621N-linked (GlcNAc...) Reviewed prediction
Glycosylationi4831 – 48311N-linked (GlcNAc...) Reviewed prediction
Glycosylationi4904 – 49041N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi4908 ↔ 4958 By similarity
Disulfide bondi4922 ↔ 4972 By similarity
Disulfide bondi4933 ↔ 4988 By similarity
Disulfide bondi4937 ↔ 4990 By similarity
Glycosylationi4967 – 49671N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

C-, O- and N-glycosylated. O-glycosylated on the Thr-/Ser-rich tandem repeats. C-mannosylation in the Cys-rich subdomains may be required for proper folding of these regions and for export from the endoplasmic reticulum during biosynthesis.2 Publications
Proteolytic cleavage in the C-terminal is initiated early in the secretory pathway and does not involve a serine protease. The extent of cleavage is increased in the acidic parts of the secretory pathway. Cleavage generates a reactive group which could link the protein to a primary amide.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP98088.
PRIDEiP98088.

PTM databases

UniCarbKBiP98088.

Expressioni

Tissue specificityi

Highly expressed in surface mucosal cells of respiratory tract and stomach epithelia. Overexpressed in a number of carcinomas. Also expressed in Barrett's esophagus epithelium and in the proximal duodenum.2 Publications

Gene expression databases

GenevestigatoriP98088.

Organism-specific databases

HPAiCAB002774.
CAB009395.
HPA040615.

Interactioni

Subunit structurei

Multimeric. Interacts with H.pylori in the gastric epithelium, Barrett's esophagus as well as in gastric metaplasia of the duodenum (GMD).1 Publication

Protein-protein interaction databases

IntActiP98088. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP98088.
SMRiP98088. Positions 336-394, 800-873, 4589-4652, 4903-4994.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini80 – 281202VWFD 1
Add
BLAST
Domaini433 – 647215VWFD 2
Add
BLAST
Domaini902 – 1109208VWFD 3
Add
BLAST
Repeati1383 – 148199Cys-rich subdomain 1
Add
BLAST
Repeati1577 – 1677101Cys-rich subdomain 2
Add
BLAST
Repeati1743 – 1847105Cys-rich subdomain 3
Add
BLAST
Repeati1950 – 2050101Cys-rich subdomain 4
Add
BLAST
Repeati2116 – 2220105Cys-rich subdomain 5
Add
BLAST
Repeati2646 – 2750105Cys-rich subdomain 6
Add
BLAST
Repeati2944 – 3084141Cys-rich subdomain 7
Add
BLAST
Repeati3377 – 3481105Cys-rich subdomain 8
Add
BLAST
Repeati4003 – 4107105Cys-rich subdomain 9
Add
BLAST
Domaini4296 – 4507212VWFD 4
Add
BLAST
Domaini4652 – 472170VWFC 1
Add
BLAST
Domaini4757 – 482468VWFC 2
Add
BLAST
Domaini4908 – 499689CTCK
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1383 – 410727259 X Cys-rich subdomain repeats
Add
BLAST
Regioni2257 – 262436846 X 8 AA approximate tandem repeats of T-T-S-T-T-S-A-P
Add
BLAST
Regioni2787 – 292213617 X 8 AA approximate tandem repeats of T-T-S-T-T-S-A-P
Add
BLAST
Regioni3085 – 335527134 X 8 AA approximate tandem repeats of T-T-S-T-T-S-A-P
Add
BLAST
Regioni3517 – 397145558 X 8 AA approximate tandem repeats of T-T-S-T-T-S-A-P
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1193 – 11953Cell attachment site Reviewed prediction

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi4896 – 49016Poly-Pro

Domaini

The cysteine residues in the Cys-rich subdomain repeats are not involved in disulfide bonding.

Sequence similaritiesi

Contains 2 VWFC domains.
Contains 4 VWFD domains.

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

InParanoidiP98088.

Family and domain databases

InterProiIPR006207. Cys_knot_C.
IPR002919. TIL_dom.
IPR014853. Unchr_dom_Cys-rich.
IPR001007. VWF_C.
IPR001846. VWF_type-D.
IPR025155. WxxW_domain.
[Graphical view]
PfamiPF08742. C8. 4 hits.
PF13330. Mucin2_WxxW. 9 hits.
PF01826. TIL. 3 hits.
PF00094. VWD. 4 hits.
[Graphical view]
SMARTiSM00832. C8. 4 hits.
SM00041. CT. 1 hit.
SM00214. VWC. 6 hits.
SM00216. VWD. 4 hits.
[Graphical view]
SUPFAMiSSF57567. SSF57567. 4 hits.
PROSITEiPS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS01208. VWFC_1. 2 hits.
PS50184. VWFC_2. 2 hits.
PS51233. VWFD. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Fragments.

Sequence processingi: The displayed sequence is further processed into a mature form.

P98088-1 [UniParc]FASTAAdd to Basket

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MSVGRRKLAL LWALALALAC TRHTGHAQDG SSESSYKHHP ALSPIARGPS     50
GVPLRGATVF PSLRTIPVVR ASNPAHNGRV CSTWGSFHYK TFDGDVFRFP 100
GLCNYVFSEH CGAAYEDFNI QLRRSQESAA PTLSRVLMKV DGVVIQLTKG 150
SVLVNGHPVL LPFSQSGVLI QQSSSYTKVE ARLGLVLMWN HDDSLLLELD 200
TKYANKTCGL CGDFNGMPVV SELLSHNTKL TPMEFGNLQK MDDPTEQCQD 250
PVPEPPRNCS TGFGICEELL HGQLFSGCVA LVDVGSYLEA CRQDLCFCED 300
TDLLSCVCHT LAEYSRQCTH AGGLPQDWRG PDFCPQKCPN NMQYHECRSP 350
CADTCSNQEH SRACEDHCVA GCFCPEGTVL DDIGQTGCVP VSKCACVYNG 400
AAYAPGATYS TDCTNCTCSG GRWSCQEVPC PDTCSVLGGA HFSTFDGKQY 450
TVHGDCSYVL TKPCDSSAFT VLAELRRCGL TDSETCLKSV TLSLDGAQTV 500
VVIKASGEVF LNQIYTQLPI SAANVTIFRP STFFIIAQTS LGLQLNLQPV 550
PTMQLFMQLA PKLRGQTCGL CGNFNSIQAD DFRTLSGVVE ATAAAFFNTF 600
KTQAACPNIR NSFEDPCSLS VENEKYAQHW CSQLTDADGP FGRCHAAVKP 650
GTYYSNCVFD TCNCERSEDC LCAALSSYVH ACAAKGVQLG GWRDGVCTKP 700
MTTCPKSMTY HYHVSTCQPT CRSLSEGDIT CSVGFIPVDG CICPKGTFLD 750
DTGKCVQASN CPCYHRGSMI PNGESVHDSG AICTCTHGKL SCIGGQAPAP 800
VCAAPMVFFD CRNATPGDTG AGCQKSCHTL DMTCYSPQCV PGCVCPDGLV 850
ADGEGGCITA EDCPCVHNEA SYRAGQTIRV GCNTCTCDSR MWRCTDDPCL 900
ATCAVYGDGH YLTFDGQSYS FNGDCEYTLV QNHCGGKDST QDSFRVVTEN 950
VPCGTTGTTC SKAIKIFLGG FELKLSHGKV EVIGTDESQE VPYTIQQMGI 1000
YLVVDTDIGL VLLWDKKTSI FINLSPEFKG RVCGLCGNFD DIAVNDFATR 1050
SRSVVGDVLE FGNSWKLSPS CPDALAPKDP CTANPFRKSW AQKQCSILHG 1100
PTFAACHAHV EPARYYEACV NDACACDSGG DCECFCTAVA AYAQACHEVG 1150
LCVCLRTPSI CPLFCDYYNP EGQCEWHYQP CGVPCLRTCR NPRGDCLRDV 1200
RGLEGCYPKC PPEAPIFDED KMQCVATCPT PPLPPRCHVH GKSYRPGAVV 1250
PSDKNCQSCL CTERGVECTY KAEACVCTYN GQRFHPGDVI YHTTDGTGGC 1300
ISARCGANGT IERRVYPCSP TTPVPPTTFS FSTPPLVVSS THTPSNGPSS 1350
AHTGPPSSAW PTTAGTSPRT RLPTASASLP PVCGEKCLWS PWMDVSRPGR 1400
GTDSGDFDTL ENLRAHGYRV CESPRSVECR AEDAPGVPLR ALGQRVQCSP 1450
DVGLTCRNRE QASGLCYNYQ IRVQCCTPLP CSTSSSPAQT TPPTTSKTTE 1500
TRASGSSAPS STPGTVSLST ARTTPAPGTA TSVKKTFSTP SPPPVPATST 1550
SSMSTTAPGT SVVSSKPTPT EPSTSSCLQE LCTWTEWIDG SYPAPGINGG 1600
DFDTFQNLRD EGYTFCESPR SVQCRAESFP NTPLADLGQD VICSHTEGLI 1650
CLNKNQLPPI CYNYEIRIQC CETVNVCRDI TRLPKTVATT RPTPHPTGAQ 1700
TQTTFTTHMP SASTEQPTAT SRGGPTATSV TQGTHTTLVT RNCHPRCTWT 1750
KWFDVDFPSP GPHGGDKETY NNIIRSGEKI CRRPEEITRV QCRAKSHPEV 1800
SIEHLGQVVQ CSREEGLVCR NQDQQGPFKM CLNYEVRVLC CETPRGCHMT 1850
STPGSTSSSP AQTTPSTTSK TTEIQASGSS APSSTPGTVS LSTARTTPAP 1900
GTATSVKKTF STPSPPPVPA TSTSSMSTTA PGTSVVSSKP TPTEPSTSSC 1950
LQELCTWTEW IDGSYPAPGI NGGDFDTFQN LRDEGYTFCE SPRSVQCRAE 2000
SFPNTPLGRL GQDVICSHTE GLICLNKNQL PPICYNYEIR IQCCETVNVC 2050
RDITRPPKTV ATTRPTPHPT GAQTQTTFTT HMPSASTEQP TATSRGGPTA 2100
TSVTQGTHTT PVTRNCHPRC TWTTWFDVDF PSPGPHGGDK ETYNNIIRSG 2150
EKICRRPEEI TRLQCRAKSH PEVSIEHLGQ VVQCSREEGL VCRNQDQQGP 2200
FKMCLNIEVR VLCCETPKGC PVTSTPVTAP STPSGRAISP TQSTSSWQKS 2250
RTTTLVTTST TSTPQTSTTY AHTTSTTSAP TARTTSAPTT STTSVPTTST 2300
ISGPKTTPSP VPTTSTTSAA TTSTISAPTT STTSVPGTTP SPVLTTSTTS 2350
APTTRTTSAS PAGTTSGPGN TPSPVPTTST ISAPTTSITS APTTSTTSAP 2400
TSSTTSGPGT TPSPVPTTSI TSAPTTSTTS APTTSTTSAP TTSTTSAPTT 2450
STTSAPTTST TSTPTSSTTS TPQTSTTSAS TTSITSGPGT TPSPVPTTST 2500
TSAPTTSTTS AATTSTISAP TTSTTSAPTT STTSASTASK TSGLGTTPSP 2550
IPTTSTTSPP TTSTTSASTA SKTSGPGTTP SPVPTTSTIF APRTSTTSAS 2600
TTSTTPGPGT TPSPVPTTST ASVSKTSTSH VSISKTTHSQ PVTRDCHLRC 2650
TWTKWFDVDF PSPGPHGGDK ETYNNIIRSG EKICRRPEEI TRLQCRAESH 2700
PEVSIEHLGQ VVQCSREEGL VCRNQDQQGP FKMCLNYEVR VLCCETPKGC 2750
PVTSTPVTAP STPSGRATSP TQSTSSWQKS RTTTLVTTST TSTPQTSTTS 2800
APTTSTTSAP TTSTTSAPTT STTSTPQTSI SSAPTSSTTS APTSSTISAR 2850
TTSIISAPTT STTSSPTTST TSATTTSTTS APTSSTTSTP QTSKTSAATS 2900
STTSSSGTTP SPVTTTSTAS VSKTSTSHVS VSKTTHSQPV TRDCHPRCTW 2950
TKWFDVDFPS PGPHGGDKET YNNIIRSGEK ICRRPQEITR LQCRAKSHPE 3000
VSIEHLGQVV QCSREEGLVC RNQDQQGPFK MCLNYEVRVL CCETPKGCPV 3050
TSTSVTAPSP LVGEPPAQTQ STSSWQKSRT TTLVTSSITS TTQTSTTSAP 3100
TTSTTPASIP STTSAPTTST TSAPTTSTTS APTTSTTSTP QTTTSSAPTS 3150
STTSAPTTST ISAPTTSTIS APTTSTTSAP TASTTSAPTS TSSAPTTNTT 3200
SAPTTSTTSA PITSTISAPT TSTTSTPQTS TISSPTTSTT PTPQTSTTSS 3250
PTTSTTSAPT TSTTSAPTTS TTSTPQTSIS SAPTSSTTSA PTASTISAPT 3300
TSTTSFHTTS TTSPPTSSTS STPQTSKTSA ATSSTTSGSG TTPSPVPTTS 3350
TASVSKTSTS HVSVSKTTHS QPVTRDCHPR CTWTKWFDVD FPSPGPHGGD 3400
KETYNNIIRS GEKICRRPEE ITRLQCRAES HPEVSIEHLG QVVQCSREEG 3450
LVCRNQDQQG PFKMCLNYEV RVLCCETPKG CPVTSTPVTA PSTPSGRATS 3500
PTQSTSSWQK SRTTTLVTTS TTSTPQTSTT SAPTTSTIPA STPSTTSAPT 3550
TSTTSAPTTS TTSAPTHRTT SGPTTSTTLA PTTSTTSAPT TSTNSAPTTS 3600
TISASTTSTI SAPTTSTISS PTSSTTSTPQ TSKTSAATSS TTSGSGTTPS 3650
PVPTTSTTSA STTSTTSAPT TSTTSGPGTT PSPVPSTSIT SAATTSTTSA 3700
PTTRTTSAPT SSMTSGPGTT PSPVPTTSTT SAPTTSTTSG PGTTPSPVPT 3750
TSTTSAPITS TTSGPGSTPS PVPTTSTTSA PTTSTTSAST ASTTSGPTTS 3800
TTSASTTSTI SPLTTSTTSA PITSMPSGPG TTPSPVPTTS TTSAPTTSTT 3850
SGPGTTPSPV PTTSTTSAPT TSTTSASTAS TTSGPGTTPS PVPTTSTTSA 3900
PTTSTTSAST ASTTSGPGTS LSPVPTTSTT SAPTTSTTSG PGTTPSPVPT 3950
TSTTSAPTTS TTSGPGTTPS PVPTTSTTPV SKTSTSHLSV SKTTHSQPVT 4000
SDCHPLCAWT KWFDVDFPSP GPHGGDKETY NNIIRSGEKI CRRPEEITRL 4050
QCRAESHPEV NIEHLGQVVQ CSREEGLVCR NQDQQGPFKM CLNYEVRVLC 4100
CETPRGCPVT SVTPYGTSPT NALYPSLSTS MVSASVASTS VASSSVASSS 4150
VAYSTQTCFC NVADRLYPAG STIYRHRDLA GHCYYALCSQ DCQVVRGVDS 4200
DCPSTTLPPA PATSPSISTS EPVTELGCPN AVPPRKKGET WATPNCSEAT 4250
CEGNNVISLS PRTCPRVEKP TCANGYPAVK VADQDGCCHH YQCQCVCSGW 4300
GDPHYITFDG TYYTFLDNCT YVLVQQIVPV YGHFRVLVDN YFCGAEDGLS 4350
CPRSIILEYH QDRVVLTRKP VHGVMTNEII FNNKVVSPGF RKNGIVVSRI 4400
GVKMYATIPE LGVQVMFSGL IFSVEVPFSK FANNTEGQCG TCTNDRKDEC 4450
RTPRGTVVAS CSEMSGLWNV SIPDQPACHR PHPTPTTVGP TTVGSTTVGP 4500
TTVGSTTVGP TTPPAPCLPS PICHLILSKV FEPCHTVIPP LLFYEGCVFD 4550
RCHMTDLDVV CSSLELYAAL CASHDICIDW RGRTGHMCPF TCPADKVYQP 4600
CGPSNPSYCY GNDSASLGAL REAGPITEGC FCPEGMTLFS TSAQVCVPTG 4650
CPRCLGPHGE PVKVGHTVGM DCQECTCEAA TWTLTCRPKL CPLPPACPLP 4700
GFVPVPAAPQ AGQCCPQYSC ACNTSRCPAP VGCPEGARAI PTYQEGACCP 4750
VQNCSWTVCS INGTLYQPGA VVSSSLCETC RCELPGGPPS DAFVVSCETQ 4800
ICNTHCPVGF EYQEQSGQCC GTCVQVACVT NTSKSPAHLF YPGETWSDAG 4850
NHCVTHQCEK HQDGLVVVTT KKACPPLSCS LDEARMSKDG CCRFCPLPPP 4900
PYQNQSTCAV YHRSLIIQQQ GCSSSEPVRL AYCRGNCGDS SSMYSLEGNT 4950
VEHRCQCCQE LRTSLRNVTL HCTDGSSRAF SYTEVEECGC MGRRCPAPGD 5000
TQHSEEAEPE PSQEAESGSW ERGVPVSPMH 5030
Length:5,030
Mass (Da):526,608
Last modified:October 23, 2007 - v3
Checksum:i00523008FF20ACAB
GO

Sequence cautioni

The sequence AAA18431.1 differs from that shown. Reason: Frameshift at several positions.
The sequence AAC15950.1 differs from that shown. Reason: Frameshift at positions 24, 44, 671 and 683.
The sequence CAA88307.1 differs from that shown. Reason: Frameshift at position 5024.
The sequence CAH56330.1 differs from that shown. Reason: Frameshift at position 4616.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti4897 – 48971L → P.2 Publications
Corresponds to variant rs1132436 [ dbSNP | Ensembl ].
VAR_036832

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti221 – 2211S → R in AAC15950. 1 Publication
Sequence conflicti432 – 4321D → G in AAC15950. 1 Publication
Sequence conflicti549 – 5491P → L in AAC15950. 1 Publication
Sequence conflicti658 – 6581V → M in AAC15950. 1 Publication
Sequence conflicti702 – 7021T → I in AAC15950. 1 Publication
Sequence conflicti716 – 7161T → A in AAC15950. 1 Publication
Sequence conflicti817 – 8182GD → RG in AAC15950. 1 Publication
Sequence conflicti869 – 8691E → K in AAC15950. 1 Publication
Sequence conflicti978 – 9781G → R in AAC15950. 1 Publication
Sequence conflicti996 – 9961Q → R in AAC15950. 1 Publication
Sequence conflicti1803 – 18031E → N AA sequence 1 Publication
Sequence conflicti2176 – 21761E → N AA sequence 1 Publication
Sequence conflicti3004 – 30041E → N AA sequence 1 Publication
Sequence conflicti3990 – 39912VS → HE in AAA18431. 1 Publication
Sequence conflicti4203 – 42031P → R in CAA88307. 1 Publication
Sequence conflicti4260 – 42623SPR → RPP in AAA18431. 1 Publication
Sequence conflicti4275 – 42751G → A in AAA18431. 1 Publication
Sequence conflicti4389 – 43891G → A in CAA88307. 1 Publication
Sequence conflicti4457 – 44604VVAS → HASA in AAH33831. 1 Publication
Sequence conflicti4524 – 45241H → Q in CAA04737. 1 Publication
Sequence conflicti4524 – 45241H → Q in CAA04738. 1 Publication
Sequence conflicti4569 – 45691A → R in AAA18431. 1 Publication
Sequence conflicti4621 – 46211R → P in CAA88307. 1 Publication
Sequence conflicti4640 – 46401S → T in CAA04737. 1 Publication
Sequence conflicti4640 – 46401S → T in CAA04738. 1 Publication
Sequence conflicti4732 – 47321G → R in AAA18431. 1 Publication
Sequence conflicti4739 – 47391A → R in AAA18431. 1 Publication
Sequence conflicti4809 – 48091G → R in AAA18431. 1 Publication
Sequence conflicti4922 – 49221C → S in AAA18431. 1 Publication

Non-adjacent residues

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-adjacent residuesi2448 – 24492
Non-adjacent residuesi3797 – 37982

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ298317 mRNA. Translation: CAC83674.1.
AJ298318 Genomic DNA. Translation: CAC83675.1.
AJ298319 Genomic DNA. Translation: CAC83676.1.
AF015521 mRNA. Translation: AAC15950.1. Frameshift.
X81649 mRNA. Translation: CAA57309.1.
AJ001402 mRNA. Translation: CAA04737.1.
AJ001403 Genomic DNA. Translation: CAA04738.1.
U06711 mRNA. Translation: AAA18431.1. Frameshift.
Z48314 mRNA. Translation: CAA88307.1. Frameshift.
BC033831 mRNA. Translation: AAH33831.1.
AL833060 mRNA. Translation: CAH56330.1. Frameshift.
PIRiA33811.
JE0095.
UniGeneiHs.534332.
Hs.558950.
Hs.721515.

Polymorphism databases

DMDMi160370004.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Mucin database
Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ298317 mRNA. Translation: CAC83674.1 .
AJ298318 Genomic DNA. Translation: CAC83675.1 .
AJ298319 Genomic DNA. Translation: CAC83676.1 .
AF015521 mRNA. Translation: AAC15950.1 . Frameshift.
X81649 mRNA. Translation: CAA57309.1 .
AJ001402 mRNA. Translation: CAA04737.1 .
AJ001403 Genomic DNA. Translation: CAA04738.1 .
U06711 mRNA. Translation: AAA18431.1 . Frameshift.
Z48314 mRNA. Translation: CAA88307.1 . Frameshift.
BC033831 mRNA. Translation: AAH33831.1 .
AL833060 mRNA. Translation: CAH56330.1 . Frameshift.
PIRi A33811.
JE0095.
UniGenei Hs.534332.
Hs.558950.
Hs.721515.

3D structure databases

ProteinModelPortali P98088.
SMRi P98088. Positions 336-394, 800-873, 4589-4652, 4903-4994.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P98088. 1 interaction.

Protein family/group databases

MEROPSi I08.951.

PTM databases

UniCarbKBi P98088.

Polymorphism databases

DMDMi 160370004.

Proteomic databases

MaxQBi P98088.
PRIDEi P98088.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

GeneCardsi GC11P001151.
H-InvDB HIX0201650.
HGNCi HGNC:7515. MUC5AC.
HPAi CAB002774.
CAB009395.
HPA040615.
MIMi 158373. gene.
neXtProti NX_P98088.
GenAtlasi Search...

Phylogenomic databases

InParanoidi P98088.

Enzyme and pathway databases

Reactomei REACT_115606. O-linked glycosylation of mucins.
REACT_115835. Termination of O-glycan biosynthesis.

Miscellaneous databases

NextBioi 125477.
PROi P98088.
SOURCEi Search...

Gene expression databases

Genevestigatori P98088.

Family and domain databases

InterProi IPR006207. Cys_knot_C.
IPR002919. TIL_dom.
IPR014853. Unchr_dom_Cys-rich.
IPR001007. VWF_C.
IPR001846. VWF_type-D.
IPR025155. WxxW_domain.
[Graphical view ]
Pfami PF08742. C8. 4 hits.
PF13330. Mucin2_WxxW. 9 hits.
PF01826. TIL. 3 hits.
PF00094. VWD. 4 hits.
[Graphical view ]
SMARTi SM00832. C8. 4 hits.
SM00041. CT. 1 hit.
SM00214. VWC. 6 hits.
SM00216. VWD. 4 hits.
[Graphical view ]
SUPFAMi SSF57567. SSF57567. 4 hits.
PROSITEi PS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS01208. VWFC_1. 2 hits.
PS50184. VWFC_2. 2 hits.
PS51233. VWFD. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Human mucin gene MUC5AC: organization of its 5'-region and central repetitive region."
    Escande F., Aubert J.-P., Porchet N., Buisine M.P.
    Biochem. J. 358:763-772(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-2448, NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 2449-3797, NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 3798-4169.
  2. "Cloning of the amino-terminal and 5'-flanking region of the human MUC5AC mucin gene and transcriptional up-regulation by bacterial exoproducts."
    Li D., Gallup M., Fan N., Szymkowski D.E., Basbaum C.B.
    J. Biol. Chem. 273:6812-6820(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-1104.
    Tissue: Trachea.
  3. "Cloning and analysis of human gastric mucin cDNA reveals two types of conserved cysteine-rich domains."
    Klomp L.W., Van Rens L., Strous G.J.
    Biochem. J. 308:831-838(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1005-1854.
  4. "Proteolytic fragmentation and peptide mapping of human carboxyamidomethylated tracheobronchial mucin."
    Rose M.C., Kaufman B., Martin B.M.
    J. Biol. Chem. 264:8193-8199(1989) [PubMed] [Europe PMC] [Abstract]
    Tissue: Tracheobronchial mucosa.
  5. "Genomic organization of the 3'-region of the human MUC5AC mucin gene: additional evidence for a common ancestral gene for the 11p15.5 mucin gene family."
    Buisine M.P., Desseyn J.-L., Porchet N., Degand P., Laine A., Aubert J.-P.
    Biochem. J. 332:729-738(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] OF 3950-5030, VARIANT PRO-4897.
    Tissue: Placenta and Trachea.
  6. "Cloning and analysis of cDNA encoding a major airway glycoprotein, human tracheobronchial mucin (MUC5)."
    Meerzaman D., Charles P., Daskal E., Polymeropoulos M.H., Martin B.M., Rose M.C.
    J. Biol. Chem. 269:12932-12939(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 3990-5030, PARTIAL PROTEIN SEQUENCE, TISSUE SPECIFICITY.
    Tissue: Nasal polyp.
  7. "Characterization of a mucin cDNA clone isolated from HT-29 mucus secreting cells: the 3' end of MUC5AC?"
    Lesuffleur T., Roche F., Hill A.S., Lacasa M., Fox M., Swallow D.M., Zweibaum A., Real F.X.
    J. Biol. Chem. 270:13665-13673(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 4081-5030.
  8. "Cleavage in the GDPH sequence of the C-terminal cysteine-rich part of the human MUC5AC mucin."
    Lidell M.E., Hansson G.C.
    Biochem. J. 399:121-129(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 4303-4312, PROTEOLYTIC PROCESSING, MUTAGENESIS OF ASP-4302.
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4457-5030, VARIANT PRO-4897.
    Tissue: Colon.
  10. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4569-5030.
    Tissue: Stomach.
  11. Cited for: STRUCTURE OF O-LINKED CARBOHYDRATES.
  12. "The MUC5AC glycoprotein is the primary receptor for Helicobacter pylori in the human stomach."
    Van de Bovenkamp J.H., Mahdavi J., Korteland-Van Male A.M., Bueller H.A., Einerhand A.W., Boren T., Dekker J.
    Helicobacter 8:521-532(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION AS LEWIS B BLOOD GROUP ANTIGEN, TISSUE SPECIFICITY, INTERACTION WITH HELICOBACTER PYLORI.
  13. "C-Mannosylation of MUC5AC and MUC5B Cys subdomains."
    Perez-Vilar J., Randell S.H., Boucher R.C.
    Glycobiology 14:325-337(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION AT TRP-2122, SUBCELLULAR LOCATION, MUTAGENESIS OF TRP-2122.

Entry informationi

Entry nameiMUC5A_HUMAN
AccessioniPrimary (citable) accession number: P98088
Secondary accession number(s): O60460
, O76065, Q13792, Q14425, Q658Q1, Q7M4S5, Q8N4M9, Q8WWQ3, Q8WWQ4, Q8WWQ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: October 23, 2007
Last modified: September 3, 2014
This is version 130 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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