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UniProtKB - P98088 (MUC5A_HUMAN)

UniProt

P98088 - MUC5A_HUMAN

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Protein

Mucin-5AC

Gene

MUC5AC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Gel-forming glycoprotein of gastric and respiratoy tract epithelia that protects the mucosa from infection and chemical damage by binding to inhaled microrganisms and particles that are subsequently removed by the mucocilary system.

GO - Molecular functioni

  • extracellular matrix structural constituent Source: UniProtKB

GO - Biological processi

  • extracellular fibril organization Source: MGI
  • maintenance of lens transparency Source: Ensembl
  • O-glycan processing Source: Reactome
  • phosphatidylinositol-mediated signaling Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-HSA-5083625. Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC).
R-HSA-5083632. Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS).
R-HSA-5083636. Defective GALNT12 causes colorectal cancer 1 (CRCS1).
R-HSA-913709. O-linked glycosylation of mucins.
R-HSA-977068. Termination of O-glycan biosynthesis.

Protein family/group databases

MEROPSiI08.951.

Names & Taxonomyi

Protein namesi
Recommended name:
Mucin-5ACCurated
Short name:
MUC-5ACCurated
Alternative name(s):
Gastric mucin1 Publication
Lewis B blood group antigen1 Publication
Short name:
LeB1 Publication
Major airway glycoprotein1 Publication
Mucin-5 subtype AC, tracheobronchial
Tracheobronchial mucin1 Publication
Short name:
TBM1 Publication
Gene namesi
Name:MUC5AC1 PublicationImported
Synonyms:MUC51 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:7515. MUC5AC.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • extracellular space Source: UniProtKB
  • fibril Source: MGI
  • Golgi lumen Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi2122 – 21221W → A: No binding to mannose-specific lectin. Loss of secretion from the endoplasmic reticulum. 1 Publication
Mutagenesisi4926 – 49261D → A or E: Abolishes cleavage. 1 Publication

Polymorphism and mutation databases

DMDMi160370004.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727Sequence analysisAdd
BLAST
Chaini28 – 56545627Mucin-5ACSequence analysisPRO_0000158957Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi103 ↔ 111PROSITE-ProRule annotation
Glycosylationi205 – 2051N-linked (GlcNAc...)Sequence analysis
Glycosylationi258 – 2581N-linked (GlcNAc...)Sequence analysis
Glycosylationi415 – 4151N-linked (GlcNAc...)Sequence analysis
Disulfide bondi456 ↔ 464PROSITE-ProRule annotation
Glycosylationi524 – 5241N-linked (GlcNAc...)Sequence analysis
Glycosylationi1308 – 13081N-linked (GlcNAc...)Sequence analysis
Glycosylationi1389 – 13891C-linked (Man)Curated
Glycosylationi1584 – 15841C-linked (Man)Curated
Glycosylationi1749 – 17491C-linked (Man)Curated
Glycosylationi1957 – 19571C-linked (Man)Curated
Glycosylationi2122 – 21221C-linked (Man)1 Publication
Glycosylationi3228 – 32281C-linked (Man)Curated
Glycosylationi3526 – 35261C-linked (Man)Curated
Glycosylationi3774 – 37741N-linked (GlcNAc...)Sequence analysis
Glycosylationi3959 – 39591C-linked (Man)Curated
Glycosylationi4633 – 46331C-linked (Man)Curated
Glycosylationi4869 – 48691N-linked (GlcNAc...)Sequence analysis
Glycosylationi4942 – 49421N-linked (GlcNAc...)Sequence analysis
Glycosylationi5057 – 50571N-linked (GlcNAc...)Sequence analysis
Glycosylationi5093 – 50931N-linked (GlcNAc...)Sequence analysis
Glycosylationi5236 – 52361N-linked (GlcNAc...)Sequence analysis
Glycosylationi5347 – 53471N-linked (GlcNAc...)Sequence analysis
Glycosylationi5377 – 53771N-linked (GlcNAc...)Sequence analysis
Glycosylationi5386 – 53861N-linked (GlcNAc...)Sequence analysis
Glycosylationi5455 – 54551N-linked (GlcNAc...)Sequence analysis
Glycosylationi5528 – 55281N-linked (GlcNAc...)Sequence analysis
Disulfide bondi5532 ↔ 5582PROSITE-ProRule annotation
Disulfide bondi5546 ↔ 5596PROSITE-ProRule annotation
Disulfide bondi5557 ↔ 5612PROSITE-ProRule annotation
Disulfide bondi5561 ↔ 5614PROSITE-ProRule annotation
Glycosylationi5591 – 55911N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

C-, O- and N-glycosylated. O-glycosylated on the Thr-/Ser-rich tandem repeats. C-mannosylation in the Cys-rich subdomains may be required for proper folding of these regions and for export from the endoplasmic reticulum during biosynthesis.1 Publication
Proteolytic cleavage in the C-terminal is initiated early in the secretory pathway and does not involve a serine protease. The extent of cleavage is increased in the acidic parts of the secretory pathway. Cleavage generates a reactive group which could link the protein to a primary amide.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei4926 – 49272Cleavage

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PeptideAtlasiP98088.
PRIDEiP98088.

PTM databases

iPTMnetiP98088.
UniCarbKBiP98088.

Expressioni

Tissue specificityi

Highly expressed in surface mucosal cells of respiratory tract and stomach epithelia. Overexpressed in a number of carcinomas. Also expressed in Barrett's esophagus epithelium and in the proximal duodenum.2 Publications

Gene expression databases

GenevisibleiP98088. HS.

Organism-specific databases

HPAiHPA040456.
HPA040615.

Interactioni

Subunit structurei

Multimeric. Interacts with H.pylori in the gastric epithelium, Barrett's esophagus as well as in gastric metaplasia of the duodenum (GMD).1 Publication

Protein-protein interaction databases

IntActiP98088. 1 interaction.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
5AJNX-ray1.67P4254-4268[»]
5AJOX-ray1.48B2528-2543[»]
5AJPX-ray1.65B2528-2543[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini80 – 281202VWFD 1PROSITE-ProRule annotationAdd
BLAST
Domaini338 – 39457TIL 1Sequence analysisAdd
BLAST
Domaini394 – 46572VWFC 1PROSITE-ProRule annotationAdd
BLAST
Domaini433 – 647215VWFD 2PROSITE-ProRule annotationAdd
BLAST
Domaini704 – 76158TIL 2Sequence analysisAdd
BLAST
Domaini818 – 86346TIL 3Sequence analysisAdd
BLAST
Domaini902 – 1109208VWFD 3PROSITE-ProRule annotationAdd
BLAST
Repeati1383 – 148199Cys-rich subdomain 1Add
BLAST
Repeati1577 – 1677101Cys-rich subdomain 2Add
BLAST
Repeati1743 – 1847105Cys-rich subdomain 3Add
BLAST
Repeati1950 – 2050101Cys-rich subdomain 4Add
BLAST
Repeati2116 – 2220105Cys-rich subdomain 5Add
BLAST
Repeati3222 – 3326105Cys-rich subdomain 6Add
BLAST
Repeati3520 – 3660141Cys-rich subdomain 7Add
BLAST
Repeati3953 – 4057105Cys-rich subdomain 8Add
BLAST
Repeati4627 – 4731105Cys-rich subdomain 9Add
BLAST
Domaini4852 – 491867VWFC 2PROSITE-ProRule annotationAdd
BLAST
Domaini4920 – 5131212VWFD 4PROSITE-ProRule annotationAdd
BLAST
Domaini5276 – 534570VWFC 3PROSITE-ProRule annotationAdd
BLAST
Domaini5381 – 544868VWFC 4PROSITE-ProRule annotationAdd
BLAST
Domaini5532 – 562089CTCKPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1383 – 473133499 X Cys-rich subdomain repeatsAdd
BLAST
Regioni2257 – 3200944107 X 8 AA approximate tandem repeats of T-T-S-T-T-S-A-PAdd
BLAST
Regioni3363 – 349813617 X 8 AA approximate tandem repeats of T-T-S-T-T-S-A-PAdd
BLAST
Regioni3661 – 393127134 X 8 AA approximate tandem repeats of T-T-S-T-T-S-A-PAdd
BLAST
Regioni4093 – 459550358 X 8 AA approximate tandem repeats of T-T-S-T-T-S-A-PAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1490 – 158596Thr-richPROSITE-ProRule annotationAdd
BLAST
Compositional biasi1681 – 175070Thr-richPROSITE-ProRule annotationAdd
BLAST
Compositional biasi1850 – 1958109Thr-richPROSITE-ProRule annotationAdd
BLAST
Compositional biasi2054 – 212471Thr-richPROSITE-ProRule annotationAdd
BLAST
Compositional biasi2223 – 46182396Thr-richPROSITE-ProRule annotationAdd
BLAST
Compositional biasi2231 – 46152385Ser-richPROSITE-ProRule annotationAdd
BLAST
Compositional biasi4750 – 477829Ser-richPROSITE-ProRule annotationAdd
BLAST
Compositional biasi5520 – 55256Poly-ProSequence analysis

Domaini

The cysteine residues in the Cys-rich subdomain repeats are not involved in disulfide bonding.

Sequence similaritiesi

Contains 1 CTCK (C-terminal cystine knot-like) domain.PROSITE-ProRule annotation
Contains 3 TIL (trypsin inhibitory-like) domains.Sequence analysis
Contains 4 VWFC domains.PROSITE-ProRule annotation
Contains 4 VWFD domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

GeneTreeiENSGT00760000118896.
InParanoidiP98088.
OMAiCSNEDNA.
OrthoDBiEOG091G0006.

Family and domain databases

InterProiIPR006207. Cys_knot_C.
IPR002919. TIL_dom.
IPR014853. Unchr_dom_Cys-rich.
IPR001007. VWF_dom.
IPR001846. VWF_type-D.
IPR025155. WxxW_domain.
[Graphical view]
PfamiPF08742. C8. 4 hits.
PF13330. Mucin2_WxxW. 9 hits.
PF01826. TIL. 3 hits.
PF00094. VWD. 4 hits.
[Graphical view]
SMARTiSM00832. C8. 4 hits.
SM00041. CT. 1 hit.
SM00214. VWC. 6 hits.
SM00215. VWC_out. 2 hits.
SM00216. VWD. 4 hits.
[Graphical view]
SUPFAMiSSF57567. SSF57567. 4 hits.
PROSITEiPS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS01208. VWFC_1. 2 hits.
PS50184. VWFC_2. 2 hits.
PS51233. VWFD. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P98088-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVGRRKLAL LWALALALAC TRHTGHAQDG SSESSYKHHP ALSPIARGPS 
        60         70         80         90        100
GVPLRGATVF PSLRTIPVVR ASNPAHNGRV CSTWGSFHYK TFDGDVFRFP 
       110        120        130        140        150
GLCNYVFSEH CGAAYEDFNI QLRRSQESAA PTLSRVLMKV DGVVIQLTKG 
       160        170        180        190        200
SVLVNGHPVL LPFSQSGVLI QQSSSYTKVE ARLGLVLMWN HDDSLLLELD 
       210        220        230        240        250
TKYANKTCGL CGDFNGMPVV SELLSHNTKL TPMEFGNLQK MDDPTDQCQD 
       260        270        280        290        300
PVPEPPRNCS TGFGICEELL HGQLFSGCVA LVDVGSYLEA CRQDLCFCED 
       310        320        330        340        350
TDLLSCVCHT LAEYSRQCTH AGGLPQDWRG PDFCPQKCPN NMQYHECRSP 
       360        370        380        390        400
CADTCSNQEH SRACEDHCVA GCFCPEGTVL DDIGQTGCVP VSKCACVYNG 
       410        420        430        440        450
AAYAPGATYS TDCTNCTCSG GRWSCQEVPC PGTCSVLGGA HFSTFDGKQY 
       460        470        480        490        500
TVHGDCSYVL TKPCDSSAFT VLAELRRCGL TDSETCLKSV TLSLDGAQTV 
       510        520        530        540        550
VVIKASGEVF LNQIYTQLPI SAANVTIFRP STFFIIAQTS LGLQLNLQLV 
       560        570        580        590        600
PTMQLFMQLA PKLRGQTCGL CGNFNSIQAD DFRTLSGVVE ATAAAFFNTF 
       610        620        630        640        650
KTQAACPNIR NSFEDPCSLS VENEKYAQHW CSQLTDADGP FGRCHAAVKP 
       660        670        680        690        700
GTYYSNCMFD TCNCERSEDC LCAALSSYVH ACAAKGVQLG GWRDGVCTKP 
       710        720        730        740        750
MTTCPKSMTY HYHVSTCQPT CRSLSEGDIT CSVGFIPVDG CICPKGTFLD 
       760        770        780        790        800
DTGKCVQASN CPCYHRGSMI PNGESVHDSG AICTCTHGKL SCIGGQAPAP 
       810        820        830        840        850
VCAAPMVFFD CRNATPGDTG AGCQKSCHTL DMTCYSPQCV PGCVCPDGLV 
       860        870        880        890        900
ADGEGGCITA EDCPCVHNEA SYRAGQTIRV GCNTCTCDSR MWRCTDDPCL 
       910        920        930        940        950
ATCAVYGDGH YLTFDGQSYS FNGDCEYTLV QNHCGGKDST QDSFRVVTEN 
       960        970        980        990       1000
VPCGTTGTTC SKAIKIFLGG FELKLSHGKV EVIGTDESQE VPYTIRQMGI 
      1010       1020       1030       1040       1050
YLVVDTDIGL VLLWDKKTSI FINLSPEFKG RVCGLCGNFD DIAVNDFATR 
      1060       1070       1080       1090       1100
SRSVVGDVLE FGNSWKLSPS CPDALAPKDP CTANPFRKSW AQKQCSILHG 
      1110       1120       1130       1140       1150
PTFAACHAHV EPARYYEACV NDACACDSGG DCECFCTAVA AYAQACHEVG 
      1160       1170       1180       1190       1200
LCVSWRTPSI CPLFCDYYNP EGQCEWHYQP CGVPCLRTCR NPRGDCLRDV 
      1210       1220       1230       1240       1250
RGLEGCYPKC PPEAPIFDED KMQCVATCPT PPLPPRCHVH GKSYRPGAVV 
      1260       1270       1280       1290       1300
PSDKNCQSCL CTERGVECTY KAEACVCTYN GQRFHPGDVI YHTTDGTGGC 
      1310       1320       1330       1340       1350
ISARCGANGT IERRVYPCSP TTPVPPTTFS FSTPPLVVSS THTPSNGPSS 
      1360       1370       1380       1390       1400
AHTGPPSSAW PTTAGTSPRT RLPTASASLP PVCGEKCLWS PWMDVSRPGR 
      1410       1420       1430       1440       1450
GTDSGDFDTL ENLRAHGYRV CESPRSVECR AEDAPGVPLR ALGQRVQCSP 
      1460       1470       1480       1490       1500
DVGLTCRNRE QASGLCYNYQ IRVQCCTPLP CSTSSSPAQT TPPTTSKTTE 
      1510       1520       1530       1540       1550
TRASGSSAPS STPGTVSLST ARTTPAPGTA TSVKKTFSTP SPPPVPATST 
      1560       1570       1580       1590       1600
SSMSTTAPGT SVVSSKPTPT EPSTSSCLQE LCTWTEWIDG SYPAPGINGG 
      1610       1620       1630       1640       1650
DFDTFQNLRD EGYTFCESPR SVQCRAESFP NTPLADLGQD VICSHTEGLI 
      1660       1670       1680       1690       1700
CLNKNQLPPI CYNYEIRIQC CETVNVCRDI TRLPKTVATT RPTPHPTGAQ 
      1710       1720       1730       1740       1750
TQTTFTTHMP SASTEQPTAT SRGGPTATSV TQGTHTTLVT RNCHPRCTWT 
      1760       1770       1780       1790       1800
KWFDVDFPSP GPHGGDKETY NNIIRSGEKI CRRPEEITRL QCRAKSHPEV 
      1810       1820       1830       1840       1850
SIEHLGQVVQ CSREEGLVCR NQDQQGPFKM CLNYEVRVLC CETPRGCHMT 
      1860       1870       1880       1890       1900
STPGSTSSSP AQTTPSTTSK TTETQASGSS APSSTPGTVS LSTARTTPAP 
      1910       1920       1930       1940       1950
GTATSVKKTF STPSPPPVPA TSTSSMSTTA PGTSVVSSKP TPTEPSTSSC 
      1960       1970       1980       1990       2000
LQELCTWTEW IDGSYPAPGI NGGDFDTFQN LRDEGYTFCE SPRSVQCRAE 
      2010       2020       2030       2040       2050
SFPNTPLADL GQDVICSHTE GLICLNKNQL PPICYNYEIR IQCCETVNVC 
      2060       2070       2080       2090       2100
RDITRPPKTV ATTRPTPHPT GAQTQTTFTT HMPSASTEQP TATSRGGPTA 
      2110       2120       2130       2140       2150
TSVTQGTHTT PVTRNCHPRC TWTTWFDVDF PSPGPHGGDK ETYNNIIRSG 
      2160       2170       2180       2190       2200
EKICRRPEEI TRLQCRAKSH PEVSIEHLGQ VVQCSREEGL VCRNQDQQGP 
      2210       2220       2230       2240       2250
FKMCLNYEVR VLCCETPKGC PVTSTPVTAP STPSGRATSP TQSTSSWQKS 
      2260       2270       2280       2290       2300
RTTTLVTTST TSTPQTSTTY AHTTSTTSAP TARTTSAPTT RTTSASPAST 
      2310       2320       2330       2340       2350
TSGPGNTPSP VPTTSTISAP TTSITSAPTT STTSAPTSST TSGPGTTPSP 
      2360       2370       2380       2390       2400
VPTTSITSAP TTSTTSAPTT STTSARTSST TSATTTSRIS GPETTPSPVP 
      2410       2420       2430       2440       2450
TTSTTSATTT STTSAPTTST TSAPTSSTTS SPQTSTTSAP TTSTTSGPGT 
      2460       2470       2480       2490       2500
TPSPVPTTST TSAPTTRTTS APKSSTTSAA TTSTTSGPET TPRPVPTTST 
      2510       2520       2530       2540       2550
TSSPTTSTTS APTTSTTSAS TTSTTSGAGT TPSPVPTTST TSAPTTSTTS 
      2560       2570       2580       2590       2600
APISSTTSAT TTSTTSGPGT TPSPVPTTST TSAPTTSTTS GPGTTPSAVP 
      2610       2620       2630       2640       2650
TTSITSAPTT STNSAPISST TSATTTSRIS GPETTPSPVP TASTTSASTT 
      2660       2670       2680       2690       2700
STTSGPGTTP SPVPTTSTIS VPTTSTTSAS TTSTTSASTT STTSGPGTTP 
      2710       2720       2730       2740       2750
SPVPTTSTTS APTTSTTSAP TTSTISAPTT STTSATTTST TSAPTPRRTS 
      2760       2770       2780       2790       2800
APTTSTISAS TTSTTSATTT STTSATTTST ISAPTTSTTL SPTTSTTSTT 
      2810       2820       2830       2840       2850
ITSTTSAPIS STTSTPQTST TSAPTTSTTS GPGTTSSPVP TTSTTSAPTT 
      2860       2870       2880       2890       2900
STTSAPTTRT TSVPTSSTTS TATTSTTSGP GTTPSPVPTT STTSAPTTRT 
      2910       2920       2930       2940       2950
TSAPTTSTTS APTTSTTSAP TSSTTSATTT STISVPTTST TSVPGTTPSP 
      2960       2970       2980       2990       3000
VPTTSTISVP TTSTTSASTT STTSGPGTTP SPVPTTSTTS APTTSTTSAP 
      3010       3020       3030       3040       3050
TTSTISAPTT STPSAPTTST TLAPTTSTTS APTTSTTSTP TSSTTSSPQT 
      3060       3070       3080       3090       3100
STTSASTTSI TSGPGTTPSP VPTTSTTSAP TTSTTSAATT STISAPTTST 
      3110       3120       3130       3140       3150
TSAPTTSTTS ASTASKTSGL GTTPSPIPTT STTSPPTTST TSASTASKTS 
      3160       3170       3180       3190       3200
GPGTTPSPVP TTSTIFAPRT STTSASTTST TPGPGTTPSP VPTTSTASVS 
      3210       3220       3230       3240       3250
KTSTSHVSIS KTTHSQPVTR DCHLRCTWTK WFDIDFPSPG PHGGDKETYN 
      3260       3270       3280       3290       3300
NIIRSGEKIC RRPEEITRLQ CRAESHPEVS IEHLGQVVQC SREEGLVCRN 
      3310       3320       3330       3340       3350
QDQQGPFKMC LNYEVRVLCC ETPKGCPVTS TPVTAPSTPS GRATSPTQST 
      3360       3370       3380       3390       3400
SSWQKSRTTT LVTTSTTSTP QTSTTSAPTT STTSAPTTST TSAPTTSTTS 
      3410       3420       3430       3440       3450
TPQTSISSAP TSSTTSAPTS STISARTTSI ISAPTTSTTS SPTTSTTSAT 
      3460       3470       3480       3490       3500
TTSTTSAPTS STTSTPQTSK TSAATSSTTS GSGTTPSPVT TTSTASVSKT 
      3510       3520       3530       3540       3550
STSHVSVSKT THSQPVTRDC HPRCTWTKWF DVDFPSPGPH GGDKETYNNI 
      3560       3570       3580       3590       3600
IRSGEKICRR PEEITRLQCR AKSHPEVSIE HLGQVVQCSR EEGLVCRNQD 
      3610       3620       3630       3640       3650
QQGPFKMCLN YEVRVLCCET PKGCPVTSTS VTAPSTPSGR ATSPTQSTSS 
      3660       3670       3680       3690       3700
WQKSRTTTLV TSSITSTTQT STTSAPTTST TPASIPSTTS APTTSTTSAP 
      3710       3720       3730       3740       3750
TTSTTSAPTT STTSTPQTTT SSAPTSSTTS APTTSTISAP TTSTISAPTT 
      3760       3770       3780       3790       3800
STTSAPTAST TSAPTSTSSA PTTNTTSAPT TSTTSAPITS TISAPTTSTT 
      3810       3820       3830       3840       3850
STPQTSTISS PTTSTTSTPQ TSTTSSPTTS TTSAPTTSTT SAPTTSTTST 
      3860       3870       3880       3890       3900
PQTSISSAPT SSTTSAPTAS TISAPTTSTT SFHTTSTTSP PTSSTSSTPQ 
      3910       3920       3930       3940       3950
TSKTSAATSS TTSGSGTTPS PVPTTSTASV SKTSTSHVSV SKTTHSQPVT 
      3960       3970       3980       3990       4000
RDCHPRCTWT KWFDVDFPSP GPHGGDKETY NNIIRSGEKI CRRPEEITRL 
      4010       4020       4030       4040       4050
QCRAESHPEV SIEHLGQVVQ CSREEGLVCR NQDQQGPFKM CLNYEVRVLC 
      4060       4070       4080       4090       4100
CETPKGCPVT STPVTAPSTP SGRATSPTQS TSSWQKSRTT TLVTTSTTST 
      4110       4120       4130       4140       4150
PQTSTTSAPT TSTIPASTPS TTSAPTTSTT SAPTTSTTSA PTHRTTSGPT 
      4160       4170       4180       4190       4200
TSTTLAPTTS TTSAPTTSTN SAPTTSTISA STTSTISAPT TSTISSPTSS 
      4210       4220       4230       4240       4250
TTSTPQTSKT SAATSSTTSG SGTTPSPVPT TSTTSASTTS TTSAPTTSTT 
      4260       4270       4280       4290       4300
SGPGTTPSPV PSTSTTSAAT TSTTSAPTTR TTSAPTSSMT SGPGTTPSPV 
      4310       4320       4330       4340       4350
PTTSTTSAPT TSTTSGPGTT PSPVPTTSTT SAPITSTTSG PGSTPSPVPT 
      4360       4370       4380       4390       4400
TSTTSAPTTS TTSASTASTT SGPGTTPSPV PTTSTTSAPT TRTTSASTAS 
      4410       4420       4430       4440       4450
TTSGPGSTPS PVPTTSTTSA PTTRTTPAST ASTTSGPGTT PSPVPTTSTT 
      4460       4470       4480       4490       4500
SASTTSTISL PTTSTTSAPI TSMTSGPGTT PSPVPTTSTT SAPTTSTTSA 
      4510       4520       4530       4540       4550
STASTTSGPG TTPSPVPTTS TTSAPTTSTT SASTASTTSG PGTSLSPVPT 
      4560       4570       4580       4590       4600
TSTTSAPTTS TTSGPGTTPS PVPTTSTTSA PTTSTTSGPG TTPSPVPTTS 
      4610       4620       4630       4640       4650
TTPVSKTSTS HLSVSKTTHS QPVTSDCHPL CAWTKWFDVD FPSPGPHGGD 
      4660       4670       4680       4690       4700
KETYNNIIRS GEKICRRPEE ITRLQCRAES HPEVNIEHLG QVVQCSREEG 
      4710       4720       4730       4740       4750
LVCRNQDQQG PFKMCLNYEV RVLCCETPRG CPVTSVTPYG TSPTNALYPS 
      4760       4770       4780       4790       4800
LSTSMVSASV ASTSVASSSV ASSSVAYSTQ TCFCNVADRL YPAGSTIYRH 
      4810       4820       4830       4840       4850
RDLAGHCYYA LCSQDCQVVR GVDSDCPSTT LPPAPATSPS ISTSEPVTEL 
      4860       4870       4880       4890       4900
GCPNAVPPRK KGETWATPNC SEATCEGNNV ISLRPRTCPR VEKPTCANGY 
      4910       4920       4930       4940       4950
PAVKVADQDG CCHHYQCQCV CSGWGDPHYI TFDGTYYTFL DNCTYVLVQQ 
      4960       4970       4980       4990       5000
IVPVYGHFRV LVDNYFCGAE DGLSCPRSII LEYHQDRVVL TRKPVHGVMT 
      5010       5020       5030       5040       5050
NEIIFNNKVV SPGFRKNGIV VSRIGVKMYA TIPELGVQVM FSGLIFSVEV 
      5060       5070       5080       5090       5100
PFSKFANNTE GQCGTCTNDR KDECRTPRGT VVASCSEMSG LWNVSIPDQP 
      5110       5120       5130       5140       5150
ACHRPHPTPT TVGPTTVGST TVGPTTVGST TVGPTTPPAP CLPSPICQLI 
      5160       5170       5180       5190       5200
LSKVFEPCHT VIPPLLFYEG CVFDRCHMTD LDVVCSSLEL YAALCASHDI 
      5210       5220       5230       5240       5250
CIDWRGRTGH MCPFTCPADK VYQPCGPSNP SYCYGNDSAS LGALPEAGPI 
      5260       5270       5280       5290       5300
TEGCFCPEGM TLFSTSAQVC VPTGCPRCLG PHGEPVKVGH TVGMDCQECT 
      5310       5320       5330       5340       5350
CEAATWTLTC RPKLCPLPPA CPLPGFVPVP AAPQAGQCCP QYSCACNTSR 
      5360       5370       5380       5390       5400
CPAPVGCPEG ARAIPTYQEG ACCPVQNCSW TVCSINGTLY QPGAVVSSSL 
      5410       5420       5430       5440       5450
CETCRCELPG GPPSDAFVVS CETQICNTHC PVGFEYQEQS GQCCGTCVQV 
      5460       5470       5480       5490       5500
ACVTNTSKSP AHLFYPGETW SDAGNHCVTH QCEKHQDGLV VVTTKKACPP 
      5510       5520       5530       5540       5550
LSCSLDEARM SKDGCCRFCP PPPPPYQNQS TCAVYHRSLI IQQQGCSSSE 
      5560       5570       5580       5590       5600
PVRLAYCRGN CGDSSSMYSL EGNTVEHRCQ CCQELRTSLR NVTLHCTDGS 
      5610       5620       5630       5640       5650
SRAFSYTEVE ECGCMGRRCP APGDTQHSEE AEPEPSQEAE SGSWERGVPV 

SPMH
Length:5,654
Mass (Da):585,570
Last modified:April 1, 2015 - v4
Checksum:i13217A8257E8E2DE
GO

Sequence cautioni

The sequence AAA18431 differs from that shown. Reason: Frameshift at several positions. Curated
The sequence AAA18431 differs from that shown. Reason: Erroneous termination at position 4999. Translated as Met.Curated
The sequence AAC15950 differs from that shown. Reason: Frameshift at positions 24, 44, 671 and 683. Curated
The sequence CAA88307 differs from that shown. Reason: Frameshift at position 5649. Curated
The sequence CAH56330 differs from that shown. Reason: Frameshift at positions 5240, 5247 and 5253. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti25 – 251G → S in AAC15950 (PubMed:9506983).Curated
Sequence conflicti221 – 2211S → R in AAC15950 (PubMed:9506983).Curated
Sequence conflicti246 – 2461D → E in CAC83674 (PubMed:11535137).Curated
Sequence conflicti246 – 2461D → E in AAC15950 (PubMed:9506983).Curated
Sequence conflicti432 – 4321G → D in CAC83674 (PubMed:11535137).Curated
Sequence conflicti549 – 5491L → P in CAC83674 (PubMed:11535137).Curated
Sequence conflicti658 – 6581M → V in CAC83674 (PubMed:11535137).Curated
Sequence conflicti702 – 7021T → I in AAC15950 (PubMed:9506983).Curated
Sequence conflicti716 – 7161T → A in AAC15950 (PubMed:9506983).Curated
Sequence conflicti817 – 8182GD → RG in AAC15950 (PubMed:9506983).Curated
Sequence conflicti869 – 8691E → K in AAC15950 (PubMed:9506983).Curated
Sequence conflicti978 – 9781G → R in AAC15950 (PubMed:9506983).Curated
Sequence conflicti996 – 9961R → Q in CAC83674 (PubMed:11535137).Curated
Sequence conflicti1141 – 11411A → R in CAA57309 (PubMed:8948439).Curated
Sequence conflicti1151 – 11555LCVSW → TCVCL in CAA57309 (PubMed:8948439).Curated
Sequence conflicti1154 – 11552SW → CL in CAC83674 (PubMed:11535137).Curated
Sequence conflicti1480 – 14801P → A in CAA57309 (PubMed:8948439).Curated
Sequence conflicti1683 – 16831L → P in CAA57309 (PubMed:8948439).Curated
Sequence conflicti1738 – 17381L → P in CAA57309 (PubMed:8948439).Curated
Sequence conflicti1790 – 17901L → V in CAC83674 (PubMed:11535137).Curated
Sequence conflicti1790 – 17901L → V in CAA57309 (PubMed:8948439).Curated
Sequence conflicti1803 – 18031E → N AA sequence (PubMed:2656675).Curated
Sequence conflicti1874 – 18741T → I in CAC83674 (PubMed:11535137).Curated
Sequence conflicti2008 – 20092AD → GR in CAC83674 (PubMed:11535137).Curated
Sequence conflicti2176 – 21761E → N AA sequence (PubMed:2656675).Curated
Sequence conflicti2207 – 22071Y → I in CAC83674 (PubMed:11535137).Curated
Sequence conflicti2238 – 22381T → I in CAC83674 (PubMed:11535137).Curated
Sequence conflicti2289 – 42371949Missing in CAC83674 (PubMed:11535137).CuratedAdd
BLAST
Sequence conflicti3047 – 30471S → T in CAC83675 (PubMed:11535137).Curated
Sequence conflicti3088 – 30881A → S in CAC83676 (PubMed:11535137).Curated
Sequence conflicti3095 – 30962AP → PL in CAC83676 (PubMed:11535137).Curated
Sequence conflicti3105 – 31051T → I in CAC83676 (PubMed:11535137).Curated
Sequence conflicti3107 – 42871181Missing in CAC83676 (PubMed:11535137).CuratedAdd
BLAST
Sequence conflicti3234 – 32341I → V in CAC83675 (PubMed:11535137).Curated
Sequence conflicti3481 – 34811G → S in CAC83675 (PubMed:11535137).Curated
Sequence conflicti3562 – 35621E → Q in CAC83675 (PubMed:11535137).Curated
Sequence conflicti3580 – 35801E → N AA sequence (PubMed:2656675).Curated
Sequence conflicti3636 – 36449TPSGRATSP → PLVGEPPAQ in CAC83675 (PubMed:11535137).Curated
Sequence conflicti3817 – 38171S → P in CAC83675 (PubMed:11535137).Curated
Sequence conflicti4244 – 42441A → V in CAC83674 (PubMed:11535137).Curated
Sequence conflicti4250 – 42545TSGPG → ISGPK in CAC83674 (PubMed:11535137).Curated
Sequence conflicti4262 – 42621S → T in CAC83674 (PubMed:11535137).Curated
Sequence conflicti4265 – 42651T → I in CAC83675 (PubMed:11535137).Curated
Sequence conflicti4274 – 42741T → I in CAC83674 (PubMed:11535137).Curated
Sequence conflicti4280 – 42845RTTSA → STTSV in CAC83674 (PubMed:11535137).Curated
Sequence conflicti4286 – 437388Missing in CAC83674 (PubMed:11535137).CuratedAdd
BLAST
Sequence conflicti4290 – 42901T → P in CAC83676 (PubMed:11535137).Curated
Sequence conflicti4314 – 4473160Missing in CAC83676 (PubMed:11535137).CuratedAdd
BLAST
Sequence conflicti4381 – 43811P → L in CAC83674 (PubMed:11535137).Curated
Sequence conflicti4398 – 44003TAS → PAG in CAC83674 (PubMed:11535137).Curated
Sequence conflicti4407 – 44071S → N in CAC83674 (PubMed:11535137).Curated
Sequence conflicti4418 – 44181T → I in CAC83674 (PubMed:11535137).Curated
Sequence conflicti4421 – 448464Missing in CAC83674 (PubMed:11535137).CuratedAdd
BLAST
Sequence conflicti4489 – 44891T → I in CAC83674 (PubMed:11535137).Curated
Sequence conflicti4501 – 45033STA → PTS in CAC83674 (PubMed:11535137).Curated
Sequence conflicti4521 – 45211T → I in CAC83674 (PubMed:11535137).Curated
Sequence conflicti4533 – 457240Missing in CAC83674 (PubMed:11535137).CuratedAdd
BLAST
Sequence conflicti4588 – 45881G → A in CAC83674 (PubMed:11535137).Curated
Sequence conflicti4614 – 46152VS → HE in AAA18431 (PubMed:7513696).Curated
Sequence conflicti4827 – 48271P → R in CAA88307 (PubMed:7775418).Curated
Sequence conflicti4884 – 48841R → S in CAA04737 (PubMed:9620876).Curated
Sequence conflicti4884 – 48841R → S in CAA04738 (PubMed:9620876).Curated
Sequence conflicti4884 – 48841R → S in CAA88307 (PubMed:7775418).Curated
Sequence conflicti4886 – 48861R → P in AAA18431 (PubMed:7513696).Curated
Sequence conflicti4899 – 48991G → A in AAA18431 (PubMed:7513696).Curated
Sequence conflicti4946 – 49472VL → AW in AAA18431 (PubMed:7513696).Curated
Sequence conflicti5013 – 50131G → A in CAA88307 (PubMed:7775418).Curated
Sequence conflicti5081 – 50844VVAS → HASA in AAH33831 (PubMed:15489334).Curated
Sequence conflicti5148 – 51481Q → H in CAA88307 (PubMed:7775418).Curated
Sequence conflicti5148 – 51481Q → H in AAA18431 (PubMed:7513696).Curated
Sequence conflicti5209 – 52102GH → RD in AAA18431 (PubMed:7513696).Curated
Sequence conflicti5245 – 52451P → R in CAA04737 (PubMed:9620876).Curated
Sequence conflicti5245 – 52451P → R in CAA04738 (PubMed:9620876).Curated
Sequence conflicti5245 – 52451P → R in AAA18431 (PubMed:7513696).Curated
Sequence conflicti5264 – 52641S → T in CAA04737 (PubMed:9620876).Curated
Sequence conflicti5264 – 52641S → T in CAA04738 (PubMed:9620876).Curated
Sequence conflicti5356 – 53561G → R in AAA18431 (PubMed:7513696).Curated
Sequence conflicti5363 – 53631A → R in AAA18431 (PubMed:7513696).Curated
Sequence conflicti5433 – 54331G → R in AAA18431 (PubMed:7513696).Curated
Sequence conflicti5441 – 54411G → A in AAA18431 (PubMed:7513696).Curated
Sequence conflicti5546 – 55461C → S in AAA18431 (PubMed:7513696).Curated
Sequence conflicti5622 – 56221P → A in AAA18431 (PubMed:7513696).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti5521 – 55211P → L.2 Publications
Corresponds to variant rs1132436 [ dbSNP | Ensembl ].		VAR_036832

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO680660 Genomic DNA. No translation available.
FP326773 Genomic DNA. No translation available.
KC800812 Genomic DNA. No translation available.
AJ298317 mRNA. Translation: CAC83674.1.
AJ298318 Genomic DNA. Translation: CAC83675.1.
AJ298319 Genomic DNA. Translation: CAC83676.1.
AF015521 mRNA. Translation: AAC15950.1. Frameshift.
X81649 mRNA. Translation: CAA57309.1.
AJ001402 mRNA. Translation: CAA04737.1.
AJ001403 Genomic DNA. Translation: CAA04738.1.
U06711 mRNA. Translation: AAA18431.1. Sequence problems.
Z48314 mRNA. Translation: CAA88307.1. Frameshift.
BC033831 mRNA. Translation: AAH33831.1.
AL833060 mRNA. Translation: CAH56330.1. Frameshift.
CCDSiCCDS76369.1.
PIRiA33811.
JE0095.
RefSeqiNP_001291288.1. NM_001304359.1.
UniGeneiHs.534332.
Hs.558950.
Hs.703728.
Hs.721515.

Genome annotation databases

EnsembliENST00000621226; ENSP00000485659; ENSG00000215182.
GeneIDi4586.
KEGGihsa:4586.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Mucin database
Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO680660 Genomic DNA. No translation available.
FP326773 Genomic DNA. No translation available.
KC800812 Genomic DNA. No translation available.
AJ298317 mRNA. Translation: CAC83674.1.
AJ298318 Genomic DNA. Translation: CAC83675.1.
AJ298319 Genomic DNA. Translation: CAC83676.1.
AF015521 mRNA. Translation: AAC15950.1. Frameshift.
X81649 mRNA. Translation: CAA57309.1.
AJ001402 mRNA. Translation: CAA04737.1.
AJ001403 Genomic DNA. Translation: CAA04738.1.
U06711 mRNA. Translation: AAA18431.1. Sequence problems.
Z48314 mRNA. Translation: CAA88307.1. Frameshift.
BC033831 mRNA. Translation: AAH33831.1.
AL833060 mRNA. Translation: CAH56330.1. Frameshift.
CCDSiCCDS76369.1.
PIRiA33811.
JE0095.
RefSeqiNP_001291288.1. NM_001304359.1.
UniGeneiHs.534332.
Hs.558950.
Hs.703728.
Hs.721515.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
5AJNX-ray1.67P4254-4268[»]
5AJOX-ray1.48B2528-2543[»]
5AJPX-ray1.65B2528-2543[»]
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP98088. 1 interaction.

Protein family/group databases

MEROPSiI08.951.

PTM databases

iPTMnetiP98088.
UniCarbKBiP98088.

Polymorphism and mutation databases

DMDMi160370004.

Proteomic databases

PeptideAtlasiP98088.
PRIDEiP98088.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000621226; ENSP00000485659; ENSG00000215182.
GeneIDi4586.
KEGGihsa:4586.

Organism-specific databases

CTDi4586.
GeneCardsiMUC5AC.
H-InvDBHIX0201650.
HGNCiHGNC:7515. MUC5AC.
HPAiHPA040456.
HPA040615.
MIMi158373. gene.
neXtProtiNX_P98088.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00760000118896.
InParanoidiP98088.
OMAiCSNEDNA.
OrthoDBiEOG091G0006.

Enzyme and pathway databases

ReactomeiR-HSA-5083625. Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC).
R-HSA-5083632. Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS).
R-HSA-5083636. Defective GALNT12 causes colorectal cancer 1 (CRCS1).
R-HSA-913709. O-linked glycosylation of mucins.
R-HSA-977068. Termination of O-glycan biosynthesis.

Miscellaneous databases

GenomeRNAii4586.
PROiP98088.
SOURCEiSearch...

Gene expression databases

GenevisibleiP98088. HS.

Family and domain databases

InterProiIPR006207. Cys_knot_C.
IPR002919. TIL_dom.
IPR014853. Unchr_dom_Cys-rich.
IPR001007. VWF_dom.
IPR001846. VWF_type-D.
IPR025155. WxxW_domain.
[Graphical view]
PfamiPF08742. C8. 4 hits.
PF13330. Mucin2_WxxW. 9 hits.
PF01826. TIL. 3 hits.
PF00094. VWD. 4 hits.
[Graphical view]
SMARTiSM00832. C8. 4 hits.
SM00041. CT. 1 hit.
SM00214. VWC. 6 hits.
SM00215. VWC_out. 2 hits.
SM00216. VWD. 4 hits.
[Graphical view]
SUPFAMiSSF57567. SSF57567. 4 hits.
PROSITEiPS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS01208. VWFC_1. 2 hits.
PS50184. VWFC_2. 2 hits.
PS51233. VWFD. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMUC5A_HUMAN
AccessioniPrimary (citable) accession number: P98088
Secondary accession number(s): A0A096LPK4
, O60460, O76065, Q13792, Q14425, Q658Q1, Q7M4S5, Q8N4M9, Q8WWQ3, Q8WWQ4, Q8WWQ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: April 1, 2015
Last modified: September 7, 2016
This is version 148 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.