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P98088 (MUC5A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 129. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mucin-5AC

Short name=MUC-5AC
Alternative name(s):
Gastric mucin
Lewis B blood group antigen
Short name=LeB
Major airway glycoprotein
Mucin-5 subtype AC, tracheobronchial
Tracheobronchial mucin
Short name=TBM
Gene names
Name:MUC5AC
Synonyms:MUC5
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length5030 AA.
Sequence statusFragments.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Gel-forming glycoprotein of gastric and respiratoy tract epithelia that protects the mucosa from infection and chemical damage by binding to inhaled microrganisms and particles that are subsequently removed by the mucocilary system.

Subunit structure

Multimeric. Interacts with H.pylori in the gastric epithelium, Barrett's esophagus as well as in gastric metaplasia of the duodenum (GMD). Ref.12

Subcellular location

Secreted Ref.13.

Tissue specificity

Highly expressed in surface mucosal cells of respiratory tract and stomach epithelia. Overexpressed in a number of carcinomas. Also expressed in Barrett's esophagus epithelium and in the proximal duodenum. Ref.6 Ref.12

Domain

The cysteine residues in the Cys-rich subdomain repeats are not involved in disulfide bonding.

Post-translational modification

C-, O- and N-glycosylated. O-glycosylated on the Thr-/Ser-rich tandem repeats. C-mannosylation in the Cys-rich subdomains may be required for proper folding of these regions and for export from the endoplasmic reticulum during biosynthesis. Ref.11 Ref.13

Proteolytic cleavage in the C-terminal is initiated early in the secretory pathway and does not involve a serine protease. The extent of cleavage is increased in the acidic parts of the secretory pathway. Cleavage generates a reactive group which could link the protein to a primary amide.

Sequence similarities

Contains 1 CTCK (C-terminal cystine knot-like) domain.

Contains 2 VWFC domains.

Contains 4 VWFD domains.

Sequence caution

The sequence AAA18431.1 differs from that shown. Reason: Frameshift at several positions.

The sequence AAC15950.1 differs from that shown. Reason: Frameshift at positions 24, 44, 671 and 683.

The sequence CAA88307.1 differs from that shown. Reason: Frameshift at position 5024.

The sequence CAH56330.1 differs from that shown. Reason: Frameshift at position 4616.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2727 Potential
Chain28 – 50305003Mucin-5AC
PRO_0000158957

Regions

Domain80 – 281202VWFD 1
Domain433 – 647215VWFD 2
Domain902 – 1109208VWFD 3
Repeat1383 – 148199Cys-rich subdomain 1
Repeat1577 – 1677101Cys-rich subdomain 2
Repeat1743 – 1847105Cys-rich subdomain 3
Repeat1950 – 2050101Cys-rich subdomain 4
Repeat2116 – 2220105Cys-rich subdomain 5
Repeat2646 – 2750105Cys-rich subdomain 6
Repeat2944 – 3084141Cys-rich subdomain 7
Repeat3377 – 3481105Cys-rich subdomain 8
Repeat4003 – 4107105Cys-rich subdomain 9
Domain4296 – 4507212VWFD 4
Domain4652 – 472170VWFC 1
Domain4757 – 482468VWFC 2
Domain4908 – 499689CTCK
Region1383 – 410727259 X Cys-rich subdomain repeats
Region2257 – 262436846 X 8 AA approximate tandem repeats of T-T-S-T-T-S-A-P
Region2787 – 292213617 X 8 AA approximate tandem repeats of T-T-S-T-T-S-A-P
Region3085 – 335527134 X 8 AA approximate tandem repeats of T-T-S-T-T-S-A-P
Region3517 – 397145558 X 8 AA approximate tandem repeats of T-T-S-T-T-S-A-P
Motif1193 – 11953Cell attachment site Potential
Compositional bias4896 – 49016Poly-Pro

Sites

Site4302 – 43032Cleavage

Amino acid modifications

Glycosylation2051N-linked (GlcNAc...) Potential
Glycosylation2581N-linked (GlcNAc...) Potential
Glycosylation4151N-linked (GlcNAc...) Potential
Glycosylation5241N-linked (GlcNAc...) Potential
Glycosylation13081N-linked (GlcNAc...) Potential
Glycosylation13891C-linked (Man) Probable
Glycosylation15841C-linked (Man) Probable
Glycosylation17491C-linked (Man) Probable
Glycosylation19571C-linked (Man) Probable
Glycosylation21221C-linked (Man) Ref.13
Glycosylation26521C-linked (Man) Probable
Glycosylation29501C-linked (Man) Probable
Glycosylation31981N-linked (GlcNAc...) Potential
Glycosylation33831C-linked (Man) Probable
Glycosylation40091C-linked (Man) Probable
Glycosylation42451N-linked (GlcNAc...) Potential
Glycosylation43181N-linked (GlcNAc...) Potential
Glycosylation44331N-linked (GlcNAc...) Potential
Glycosylation44691N-linked (GlcNAc...) Potential
Glycosylation46121N-linked (GlcNAc...) Potential
Glycosylation47231N-linked (GlcNAc...) Potential
Glycosylation47531N-linked (GlcNAc...) Potential
Glycosylation47621N-linked (GlcNAc...) Potential
Glycosylation48311N-linked (GlcNAc...) Potential
Glycosylation49041N-linked (GlcNAc...) Potential
Glycosylation49671N-linked (GlcNAc...) Potential
Disulfide bond103 ↔ 111 By similarity
Disulfide bond456 ↔ 464 By similarity
Disulfide bond4908 ↔ 4958 By similarity
Disulfide bond4922 ↔ 4972 By similarity
Disulfide bond4933 ↔ 4988 By similarity
Disulfide bond4937 ↔ 4990 By similarity
Disulfide bond? ↔ 4995 By similarity

Natural variations

Natural variant48971L → P. Ref.5 Ref.9
Corresponds to variant rs1132436 [ dbSNP | Ensembl ].
VAR_036832

Experimental info

Mutagenesis21221W → A: No binding to mannose-specific lectin. Loss of secretion from the endoplasmic reticulum. Ref.13
Mutagenesis43021D → A or E: Abolishes cleavage. Ref.8
Sequence conflict2211S → R in AAC15950. Ref.2
Sequence conflict4321D → G in AAC15950. Ref.2
Sequence conflict5491P → L in AAC15950. Ref.2
Sequence conflict6581V → M in AAC15950. Ref.2
Sequence conflict7021T → I in AAC15950. Ref.2
Sequence conflict7161T → A in AAC15950. Ref.2
Sequence conflict817 – 8182GD → RG in AAC15950. Ref.2
Sequence conflict8691E → K in AAC15950. Ref.2
Sequence conflict9781G → R in AAC15950. Ref.2
Sequence conflict9961Q → R in AAC15950. Ref.2
Sequence conflict18031E → N AA sequence Ref.4
Sequence conflict21761E → N AA sequence Ref.4
Sequence conflict30041E → N AA sequence Ref.4
Sequence conflict3990 – 39912VS → HE in AAA18431. Ref.6
Sequence conflict42031P → R in CAA88307. Ref.7
Sequence conflict4260 – 42623SPR → RPP in AAA18431. Ref.6
Sequence conflict42751G → A in AAA18431. Ref.6
Sequence conflict43891G → A in CAA88307. Ref.7
Sequence conflict4457 – 44604VVAS → HASA in AAH33831. Ref.9
Sequence conflict45241H → Q in CAA04737. Ref.5
Sequence conflict45241H → Q in CAA04738. Ref.5
Sequence conflict45691A → R in AAA18431. Ref.6
Sequence conflict46211R → P in CAA88307. Ref.7
Sequence conflict46401S → T in CAA04737. Ref.5
Sequence conflict46401S → T in CAA04738. Ref.5
Sequence conflict47321G → R in AAA18431. Ref.6
Sequence conflict47391A → R in AAA18431. Ref.6
Sequence conflict48091G → R in AAA18431. Ref.6
Sequence conflict49221C → S in AAA18431. Ref.6
Non-adjacent residues2448 – 24492
Non-adjacent residues3797 – 37982

Sequences

Sequence LengthMass (Da)Tools
P98088 [UniParc].

Last modified October 23, 2007. Version 3.
Checksum: 00523008FF20ACAB

FASTA5,030526,608
        10         20         30         40         50         60 
MSVGRRKLAL LWALALALAC TRHTGHAQDG SSESSYKHHP ALSPIARGPS GVPLRGATVF 

        70         80         90        100        110        120 
PSLRTIPVVR ASNPAHNGRV CSTWGSFHYK TFDGDVFRFP GLCNYVFSEH CGAAYEDFNI 

       130        140        150        160        170        180 
QLRRSQESAA PTLSRVLMKV DGVVIQLTKG SVLVNGHPVL LPFSQSGVLI QQSSSYTKVE 

       190        200        210        220        230        240 
ARLGLVLMWN HDDSLLLELD TKYANKTCGL CGDFNGMPVV SELLSHNTKL TPMEFGNLQK 

       250        260        270        280        290        300 
MDDPTEQCQD PVPEPPRNCS TGFGICEELL HGQLFSGCVA LVDVGSYLEA CRQDLCFCED 

       310        320        330        340        350        360 
TDLLSCVCHT LAEYSRQCTH AGGLPQDWRG PDFCPQKCPN NMQYHECRSP CADTCSNQEH 

       370        380        390        400        410        420 
SRACEDHCVA GCFCPEGTVL DDIGQTGCVP VSKCACVYNG AAYAPGATYS TDCTNCTCSG 

       430        440        450        460        470        480 
GRWSCQEVPC PDTCSVLGGA HFSTFDGKQY TVHGDCSYVL TKPCDSSAFT VLAELRRCGL 

       490        500        510        520        530        540 
TDSETCLKSV TLSLDGAQTV VVIKASGEVF LNQIYTQLPI SAANVTIFRP STFFIIAQTS 

       550        560        570        580        590        600 
LGLQLNLQPV PTMQLFMQLA PKLRGQTCGL CGNFNSIQAD DFRTLSGVVE ATAAAFFNTF 

       610        620        630        640        650        660 
KTQAACPNIR NSFEDPCSLS VENEKYAQHW CSQLTDADGP FGRCHAAVKP GTYYSNCVFD 

       670        680        690        700        710        720 
TCNCERSEDC LCAALSSYVH ACAAKGVQLG GWRDGVCTKP MTTCPKSMTY HYHVSTCQPT 

       730        740        750        760        770        780 
CRSLSEGDIT CSVGFIPVDG CICPKGTFLD DTGKCVQASN CPCYHRGSMI PNGESVHDSG 

       790        800        810        820        830        840 
AICTCTHGKL SCIGGQAPAP VCAAPMVFFD CRNATPGDTG AGCQKSCHTL DMTCYSPQCV 

       850        860        870        880        890        900 
PGCVCPDGLV ADGEGGCITA EDCPCVHNEA SYRAGQTIRV GCNTCTCDSR MWRCTDDPCL 

       910        920        930        940        950        960 
ATCAVYGDGH YLTFDGQSYS FNGDCEYTLV QNHCGGKDST QDSFRVVTEN VPCGTTGTTC 

       970        980        990       1000       1010       1020 
SKAIKIFLGG FELKLSHGKV EVIGTDESQE VPYTIQQMGI YLVVDTDIGL VLLWDKKTSI 

      1030       1040       1050       1060       1070       1080 
FINLSPEFKG RVCGLCGNFD DIAVNDFATR SRSVVGDVLE FGNSWKLSPS CPDALAPKDP 

      1090       1100       1110       1120       1130       1140 
CTANPFRKSW AQKQCSILHG PTFAACHAHV EPARYYEACV NDACACDSGG DCECFCTAVA 

      1150       1160       1170       1180       1190       1200 
AYAQACHEVG LCVCLRTPSI CPLFCDYYNP EGQCEWHYQP CGVPCLRTCR NPRGDCLRDV 

      1210       1220       1230       1240       1250       1260 
RGLEGCYPKC PPEAPIFDED KMQCVATCPT PPLPPRCHVH GKSYRPGAVV PSDKNCQSCL 

      1270       1280       1290       1300       1310       1320 
CTERGVECTY KAEACVCTYN GQRFHPGDVI YHTTDGTGGC ISARCGANGT IERRVYPCSP 

      1330       1340       1350       1360       1370       1380 
TTPVPPTTFS FSTPPLVVSS THTPSNGPSS AHTGPPSSAW PTTAGTSPRT RLPTASASLP 

      1390       1400       1410       1420       1430       1440 
PVCGEKCLWS PWMDVSRPGR GTDSGDFDTL ENLRAHGYRV CESPRSVECR AEDAPGVPLR 

      1450       1460       1470       1480       1490       1500 
ALGQRVQCSP DVGLTCRNRE QASGLCYNYQ IRVQCCTPLP CSTSSSPAQT TPPTTSKTTE 

      1510       1520       1530       1540       1550       1560 
TRASGSSAPS STPGTVSLST ARTTPAPGTA TSVKKTFSTP SPPPVPATST SSMSTTAPGT 

      1570       1580       1590       1600       1610       1620 
SVVSSKPTPT EPSTSSCLQE LCTWTEWIDG SYPAPGINGG DFDTFQNLRD EGYTFCESPR 

      1630       1640       1650       1660       1670       1680 
SVQCRAESFP NTPLADLGQD VICSHTEGLI CLNKNQLPPI CYNYEIRIQC CETVNVCRDI 

      1690       1700       1710       1720       1730       1740 
TRLPKTVATT RPTPHPTGAQ TQTTFTTHMP SASTEQPTAT SRGGPTATSV TQGTHTTLVT 

      1750       1760       1770       1780       1790       1800 
RNCHPRCTWT KWFDVDFPSP GPHGGDKETY NNIIRSGEKI CRRPEEITRV QCRAKSHPEV 

      1810       1820       1830       1840       1850       1860 
SIEHLGQVVQ CSREEGLVCR NQDQQGPFKM CLNYEVRVLC CETPRGCHMT STPGSTSSSP 

      1870       1880       1890       1900       1910       1920 
AQTTPSTTSK TTEIQASGSS APSSTPGTVS LSTARTTPAP GTATSVKKTF STPSPPPVPA 

      1930       1940       1950       1960       1970       1980 
TSTSSMSTTA PGTSVVSSKP TPTEPSTSSC LQELCTWTEW IDGSYPAPGI NGGDFDTFQN 

      1990       2000       2010       2020       2030       2040 
LRDEGYTFCE SPRSVQCRAE SFPNTPLGRL GQDVICSHTE GLICLNKNQL PPICYNYEIR 

      2050       2060       2070       2080       2090       2100 
IQCCETVNVC RDITRPPKTV ATTRPTPHPT GAQTQTTFTT HMPSASTEQP TATSRGGPTA 

      2110       2120       2130       2140       2150       2160 
TSVTQGTHTT PVTRNCHPRC TWTTWFDVDF PSPGPHGGDK ETYNNIIRSG EKICRRPEEI 

      2170       2180       2190       2200       2210       2220 
TRLQCRAKSH PEVSIEHLGQ VVQCSREEGL VCRNQDQQGP FKMCLNIEVR VLCCETPKGC 

      2230       2240       2250       2260       2270       2280 
PVTSTPVTAP STPSGRAISP TQSTSSWQKS RTTTLVTTST TSTPQTSTTY AHTTSTTSAP 

      2290       2300       2310       2320       2330       2340 
TARTTSAPTT STTSVPTTST ISGPKTTPSP VPTTSTTSAA TTSTISAPTT STTSVPGTTP 

      2350       2360       2370       2380       2390       2400 
SPVLTTSTTS APTTRTTSAS PAGTTSGPGN TPSPVPTTST ISAPTTSITS APTTSTTSAP 

      2410       2420       2430       2440       2450       2460 
TSSTTSGPGT TPSPVPTTSI TSAPTTSTTS APTTSTTSAP TTSTTSAPTT STTSAPTTST 

      2470       2480       2490       2500       2510       2520 
TSTPTSSTTS TPQTSTTSAS TTSITSGPGT TPSPVPTTST TSAPTTSTTS AATTSTISAP 

      2530       2540       2550       2560       2570       2580 
TTSTTSAPTT STTSASTASK TSGLGTTPSP IPTTSTTSPP TTSTTSASTA SKTSGPGTTP 

      2590       2600       2610       2620       2630       2640 
SPVPTTSTIF APRTSTTSAS TTSTTPGPGT TPSPVPTTST ASVSKTSTSH VSISKTTHSQ 

      2650       2660       2670       2680       2690       2700 
PVTRDCHLRC TWTKWFDVDF PSPGPHGGDK ETYNNIIRSG EKICRRPEEI TRLQCRAESH 

      2710       2720       2730       2740       2750       2760 
PEVSIEHLGQ VVQCSREEGL VCRNQDQQGP FKMCLNYEVR VLCCETPKGC PVTSTPVTAP 

      2770       2780       2790       2800       2810       2820 
STPSGRATSP TQSTSSWQKS RTTTLVTTST TSTPQTSTTS APTTSTTSAP TTSTTSAPTT 

      2830       2840       2850       2860       2870       2880 
STTSTPQTSI SSAPTSSTTS APTSSTISAR TTSIISAPTT STTSSPTTST TSATTTSTTS 

      2890       2900       2910       2920       2930       2940 
APTSSTTSTP QTSKTSAATS STTSSSGTTP SPVTTTSTAS VSKTSTSHVS VSKTTHSQPV 

      2950       2960       2970       2980       2990       3000 
TRDCHPRCTW TKWFDVDFPS PGPHGGDKET YNNIIRSGEK ICRRPQEITR LQCRAKSHPE 

      3010       3020       3030       3040       3050       3060 
VSIEHLGQVV QCSREEGLVC RNQDQQGPFK MCLNYEVRVL CCETPKGCPV TSTSVTAPSP 

      3070       3080       3090       3100       3110       3120 
LVGEPPAQTQ STSSWQKSRT TTLVTSSITS TTQTSTTSAP TTSTTPASIP STTSAPTTST 

      3130       3140       3150       3160       3170       3180 
TSAPTTSTTS APTTSTTSTP QTTTSSAPTS STTSAPTTST ISAPTTSTIS APTTSTTSAP 

      3190       3200       3210       3220       3230       3240 
TASTTSAPTS TSSAPTTNTT SAPTTSTTSA PITSTISAPT TSTTSTPQTS TISSPTTSTT 

      3250       3260       3270       3280       3290       3300 
PTPQTSTTSS PTTSTTSAPT TSTTSAPTTS TTSTPQTSIS SAPTSSTTSA PTASTISAPT 

      3310       3320       3330       3340       3350       3360 
TSTTSFHTTS TTSPPTSSTS STPQTSKTSA ATSSTTSGSG TTPSPVPTTS TASVSKTSTS 

      3370       3380       3390       3400       3410       3420 
HVSVSKTTHS QPVTRDCHPR CTWTKWFDVD FPSPGPHGGD KETYNNIIRS GEKICRRPEE 

      3430       3440       3450       3460       3470       3480 
ITRLQCRAES HPEVSIEHLG QVVQCSREEG LVCRNQDQQG PFKMCLNYEV RVLCCETPKG 

      3490       3500       3510       3520       3530       3540 
CPVTSTPVTA PSTPSGRATS PTQSTSSWQK SRTTTLVTTS TTSTPQTSTT SAPTTSTIPA 

      3550       3560       3570       3580       3590       3600 
STPSTTSAPT TSTTSAPTTS TTSAPTHRTT SGPTTSTTLA PTTSTTSAPT TSTNSAPTTS 

      3610       3620       3630       3640       3650       3660 
TISASTTSTI SAPTTSTISS PTSSTTSTPQ TSKTSAATSS TTSGSGTTPS PVPTTSTTSA 

      3670       3680       3690       3700       3710       3720 
STTSTTSAPT TSTTSGPGTT PSPVPSTSIT SAATTSTTSA PTTRTTSAPT SSMTSGPGTT 

      3730       3740       3750       3760       3770       3780 
PSPVPTTSTT SAPTTSTTSG PGTTPSPVPT TSTTSAPITS TTSGPGSTPS PVPTTSTTSA 

      3790       3800       3810       3820       3830       3840 
PTTSTTSAST ASTTSGPTTS TTSASTTSTI SPLTTSTTSA PITSMPSGPG TTPSPVPTTS 

      3850       3860       3870       3880       3890       3900 
TTSAPTTSTT SGPGTTPSPV PTTSTTSAPT TSTTSASTAS TTSGPGTTPS PVPTTSTTSA 

      3910       3920       3930       3940       3950       3960 
PTTSTTSAST ASTTSGPGTS LSPVPTTSTT SAPTTSTTSG PGTTPSPVPT TSTTSAPTTS 

      3970       3980       3990       4000       4010       4020 
TTSGPGTTPS PVPTTSTTPV SKTSTSHLSV SKTTHSQPVT SDCHPLCAWT KWFDVDFPSP 

      4030       4040       4050       4060       4070       4080 
GPHGGDKETY NNIIRSGEKI CRRPEEITRL QCRAESHPEV NIEHLGQVVQ CSREEGLVCR 

      4090       4100       4110       4120       4130       4140 
NQDQQGPFKM CLNYEVRVLC CETPRGCPVT SVTPYGTSPT NALYPSLSTS MVSASVASTS 

      4150       4160       4170       4180       4190       4200 
VASSSVASSS VAYSTQTCFC NVADRLYPAG STIYRHRDLA GHCYYALCSQ DCQVVRGVDS 

      4210       4220       4230       4240       4250       4260 
DCPSTTLPPA PATSPSISTS EPVTELGCPN AVPPRKKGET WATPNCSEAT CEGNNVISLS 

      4270       4280       4290       4300       4310       4320 
PRTCPRVEKP TCANGYPAVK VADQDGCCHH YQCQCVCSGW GDPHYITFDG TYYTFLDNCT 

      4330       4340       4350       4360       4370       4380 
YVLVQQIVPV YGHFRVLVDN YFCGAEDGLS CPRSIILEYH QDRVVLTRKP VHGVMTNEII 

      4390       4400       4410       4420       4430       4440 
FNNKVVSPGF RKNGIVVSRI GVKMYATIPE LGVQVMFSGL IFSVEVPFSK FANNTEGQCG 

      4450       4460       4470       4480       4490       4500 
TCTNDRKDEC RTPRGTVVAS CSEMSGLWNV SIPDQPACHR PHPTPTTVGP TTVGSTTVGP 

      4510       4520       4530       4540       4550       4560 
TTVGSTTVGP TTPPAPCLPS PICHLILSKV FEPCHTVIPP LLFYEGCVFD RCHMTDLDVV 

      4570       4580       4590       4600       4610       4620 
CSSLELYAAL CASHDICIDW RGRTGHMCPF TCPADKVYQP CGPSNPSYCY GNDSASLGAL 

      4630       4640       4650       4660       4670       4680 
REAGPITEGC FCPEGMTLFS TSAQVCVPTG CPRCLGPHGE PVKVGHTVGM DCQECTCEAA 

      4690       4700       4710       4720       4730       4740 
TWTLTCRPKL CPLPPACPLP GFVPVPAAPQ AGQCCPQYSC ACNTSRCPAP VGCPEGARAI 

      4750       4760       4770       4780       4790       4800 
PTYQEGACCP VQNCSWTVCS INGTLYQPGA VVSSSLCETC RCELPGGPPS DAFVVSCETQ 

      4810       4820       4830       4840       4850       4860 
ICNTHCPVGF EYQEQSGQCC GTCVQVACVT NTSKSPAHLF YPGETWSDAG NHCVTHQCEK 

      4870       4880       4890       4900       4910       4920 
HQDGLVVVTT KKACPPLSCS LDEARMSKDG CCRFCPLPPP PYQNQSTCAV YHRSLIIQQQ 

      4930       4940       4950       4960       4970       4980 
GCSSSEPVRL AYCRGNCGDS SSMYSLEGNT VEHRCQCCQE LRTSLRNVTL HCTDGSSRAF 

      4990       5000       5010       5020       5030 
SYTEVEECGC MGRRCPAPGD TQHSEEAEPE PSQEAESGSW ERGVPVSPMH 

« Hide

References

« Hide 'large scale' references
[1]"Human mucin gene MUC5AC: organization of its 5'-region and central repetitive region."
Escande F., Aubert J.-P., Porchet N., Buisine M.P.
Biochem. J. 358:763-772(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-2448, NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 2449-3797, NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 3798-4169.
[2]"Cloning of the amino-terminal and 5'-flanking region of the human MUC5AC mucin gene and transcriptional up-regulation by bacterial exoproducts."
Li D., Gallup M., Fan N., Szymkowski D.E., Basbaum C.B.
J. Biol. Chem. 273:6812-6820(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-1104.
Tissue: Trachea.
[3]"Cloning and analysis of human gastric mucin cDNA reveals two types of conserved cysteine-rich domains."
Klomp L.W., Van Rens L., Strous G.J.
Biochem. J. 308:831-838(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1005-1854.
[4]"Proteolytic fragmentation and peptide mapping of human carboxyamidomethylated tracheobronchial mucin."
Rose M.C., Kaufman B., Martin B.M.
J. Biol. Chem. 264:8193-8199(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 1752-1773; 1796-1805; 2125-2146; 2169-2178; 2655-2676; 2697-2708; 2953-2974; 2997-3006; 3386-3407; 3428-3439 AND 4012-4033.
Tissue: Tracheobronchial mucosa.
[5]"Genomic organization of the 3'-region of the human MUC5AC mucin gene: additional evidence for a common ancestral gene for the 11p15.5 mucin gene family."
Buisine M.P., Desseyn J.-L., Porchet N., Degand P., Laine A., Aubert J.-P.
Biochem. J. 332:729-738(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] OF 3950-5030, VARIANT PRO-4897.
Tissue: Placenta and Trachea.
[6]"Cloning and analysis of cDNA encoding a major airway glycoprotein, human tracheobronchial mucin (MUC5)."
Meerzaman D., Charles P., Daskal E., Polymeropoulos M.H., Martin B.M., Rose M.C.
J. Biol. Chem. 269:12932-12939(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 3990-5030, PARTIAL PROTEIN SEQUENCE, TISSUE SPECIFICITY.
Tissue: Nasal polyp.
[7]"Characterization of a mucin cDNA clone isolated from HT-29 mucus secreting cells: the 3' end of MUC5AC?"
Lesuffleur T., Roche F., Hill A.S., Lacasa M., Fox M., Swallow D.M., Zweibaum A., Real F.X.
J. Biol. Chem. 270:13665-13673(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 4081-5030.
[8]"Cleavage in the GDPH sequence of the C-terminal cysteine-rich part of the human MUC5AC mucin."
Lidell M.E., Hansson G.C.
Biochem. J. 399:121-129(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 4303-4312, PROTEOLYTIC PROCESSING, MUTAGENESIS OF ASP-4302.
[9]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4457-5030, VARIANT PRO-4897.
Tissue: Colon.
[10]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4569-5030.
Tissue: Stomach.
[11]"In vivo glycosylation of mucin tandem repeats."
Silverman H.S., Parry S., Sutton-Smith M., Burdick M.D., McDermott K., Reid C.J., Batra S.K., Morris H.R., Hollingsworth M.A., Dell A., Harris A.
Glycobiology 11:459-471(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE OF O-LINKED CARBOHYDRATES.
[12]"The MUC5AC glycoprotein is the primary receptor for Helicobacter pylori in the human stomach."
Van de Bovenkamp J.H., Mahdavi J., Korteland-Van Male A.M., Bueller H.A., Einerhand A.W., Boren T., Dekker J.
Helicobacter 8:521-532(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION AS LEWIS B BLOOD GROUP ANTIGEN, TISSUE SPECIFICITY, INTERACTION WITH HELICOBACTER PYLORI.
[13]"C-Mannosylation of MUC5AC and MUC5B Cys subdomains."
Perez-Vilar J., Randell S.H., Boucher R.C.
Glycobiology 14:325-337(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION AT TRP-2122, SUBCELLULAR LOCATION, MUTAGENESIS OF TRP-2122.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ298317 mRNA. Translation: CAC83674.1.
AJ298318 Genomic DNA. Translation: CAC83675.1.
AJ298319 Genomic DNA. Translation: CAC83676.1.
AF015521 mRNA. Translation: AAC15950.1. Frameshift.
X81649 mRNA. Translation: CAA57309.1.
AJ001402 mRNA. Translation: CAA04737.1.
AJ001403 Genomic DNA. Translation: CAA04738.1.
U06711 mRNA. Translation: AAA18431.1. Frameshift.
Z48314 mRNA. Translation: CAA88307.1. Frameshift.
BC033831 mRNA. Translation: AAH33831.1.
AL833060 mRNA. Translation: CAH56330.1. Frameshift.
PIRA33811.
JE0095.
UniGeneHs.534332.
Hs.558950.
Hs.721515.

3D structure databases

ProteinModelPortalP98088.
SMRP98088. Positions 336-394, 800-873, 4589-4652, 4903-4994.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP98088. 1 interaction.

Protein family/group databases

MEROPSI08.951.

PTM databases

UniCarbKBP98088.

Polymorphism databases

DMDM160370004.

Proteomic databases

MaxQBP98088.
PRIDEP98088.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

GeneCardsGC11P001151.
H-InvDBHIX0201650.
HGNCHGNC:7515. MUC5AC.
HPACAB002774.
CAB009395.
HPA040615.
MIM158373. gene.
neXtProtNX_P98088.
GenAtlasSearch...

Phylogenomic databases

InParanoidP98088.

Enzyme and pathway databases

ReactomeREACT_17015. Metabolism of proteins.

Gene expression databases

GenevestigatorP98088.

Family and domain databases

InterProIPR006207. Cys_knot_C.
IPR002919. TIL_dom.
IPR014853. Unchr_dom_Cys-rich.
IPR001007. VWF_C.
IPR001846. VWF_type-D.
IPR025155. WxxW_domain.
[Graphical view]
PfamPF08742. C8. 4 hits.
PF13330. Mucin2_WxxW. 9 hits.
PF01826. TIL. 3 hits.
PF00094. VWD. 4 hits.
[Graphical view]
SMARTSM00832. C8. 4 hits.
SM00041. CT. 1 hit.
SM00214. VWC. 6 hits.
SM00216. VWD. 4 hits.
[Graphical view]
SUPFAMSSF57567. SSF57567. 4 hits.
PROSITEPS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS01208. VWFC_1. 2 hits.
PS50184. VWFC_2. 2 hits.
PS51233. VWFD. 4 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio125477.
PROP98088.
SOURCESearch...

Entry information

Entry nameMUC5A_HUMAN
AccessionPrimary (citable) accession number: P98088
Secondary accession number(s): O60460 expand/collapse secondary AC list , O76065, Q13792, Q14425, Q658Q1, Q7M4S5, Q8N4M9, Q8WWQ3, Q8WWQ4, Q8WWQ5
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: October 23, 2007
Last modified: May 14, 2014
This is version 129 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM