UniProtKB - P98088 (MUC5A_HUMAN)
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Protein
Mucin-5AC
Gene
MUC5AC
Organism
Homo sapiens (Human)
Status
Functioni
Gel-forming glycoprotein of gastric and respiratoy tract epithelia that protects the mucosa from infection and chemical damage by binding to inhaled microrganisms and particles that are subsequently removed by the mucocilary system.
GO - Molecular functioni
- extracellular matrix structural constituent Source: UniProtKB
GO - Biological processi
- O-glycan processing Source: Reactome
- phosphatidylinositol-mediated signaling Source: UniProtKB
- stimulatory C-type lectin receptor signaling pathway Source: Reactome
Enzyme and pathway databases
Reactomei | R-HSA-5083625. Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC). R-HSA-5083632. Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS). R-HSA-5083636. Defective GALNT12 causes colorectal cancer 1 (CRCS1). R-HSA-5621480. Dectin-2 family. R-HSA-913709. O-linked glycosylation of mucins. R-HSA-977068. Termination of O-glycan biosynthesis. |
Protein family/group databases
MEROPSi | I08.951. |
Names & Taxonomyi
Protein namesi | Recommended name: Mucin-5ACCuratedShort name: MUC-5ACCurated Alternative name(s): Gastric mucin1 Publication Lewis B blood group antigen1 Publication Short name: LeB1 Publication Major airway glycoprotein1 Publication Mucin-5 subtype AC, tracheobronchial Tracheobronchial mucin1 Publication Short name: TBM1 Publication |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000215182.8. |
HGNCi | HGNC:7515. MUC5AC. |
MIMi | 158373. gene. |
neXtProti | NX_P98088. |
Pathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 2122 | W → A: No binding to mannose-specific lectin. Loss of secretion from the endoplasmic reticulum. 1 Publication | 1 | |
Mutagenesisi | 4926 | D → A or E: Abolishes cleavage. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 4586. |
OpenTargetsi | ENSG00000215182. |
Chemistry databases
ChEMBLi | CHEMBL3713020. |
Polymorphism and mutation databases
DMDMi | 160370004. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 27 | Sequence analysisAdd BLAST | 27 | |
ChainiPRO_0000158957 | 28 – 5654 | Mucin-5ACSequence analysisAdd BLAST | 5627 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 103 ↔ 111 | PROSITE-ProRule annotation | ||
Glycosylationi | 205 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 258 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 415 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 456 ↔ 464 | PROSITE-ProRule annotation | ||
Glycosylationi | 524 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1308 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1389 | C-linked (Man) tryptophanCurated | 1 | |
Glycosylationi | 1584 | C-linked (Man) tryptophanCurated | 1 | |
Glycosylationi | 1749 | C-linked (Man) tryptophanCurated | 1 | |
Glycosylationi | 1957 | C-linked (Man) tryptophanCurated | 1 | |
Glycosylationi | 2122 | C-linked (Man) tryptophan1 Publication | 1 | |
Glycosylationi | 3228 | C-linked (Man) tryptophanCurated | 1 | |
Glycosylationi | 3526 | C-linked (Man) tryptophanCurated | 1 | |
Glycosylationi | 3774 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 3959 | C-linked (Man) tryptophanCurated | 1 | |
Glycosylationi | 4633 | C-linked (Man) tryptophanCurated | 1 | |
Glycosylationi | 4869 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 4942 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 5057 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 5093 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 5236 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 5347 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 5377 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 5386 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 5455 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 5528 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 5532 ↔ 5582 | PROSITE-ProRule annotation | ||
Disulfide bondi | 5546 ↔ 5596 | PROSITE-ProRule annotation | ||
Disulfide bondi | 5557 ↔ 5612 | PROSITE-ProRule annotation | ||
Disulfide bondi | 5561 ↔ 5614 | PROSITE-ProRule annotation | ||
Glycosylationi | 5591 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Post-translational modificationi
C-, O- and N-glycosylated. O-glycosylated on the Thr-/Ser-rich tandem repeats. C-mannosylation in the Cys-rich subdomains may be required for proper folding of these regions and for export from the endoplasmic reticulum during biosynthesis.1 Publication
Proteolytic cleavage in the C-terminal is initiated early in the secretory pathway and does not involve a serine protease. The extent of cleavage is increased in the acidic parts of the secretory pathway. Cleavage generates a reactive group which could link the protein to a primary amide.1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 4926 – 4927 | Cleavage | 2 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | P98088. |
PeptideAtlasi | P98088. |
PRIDEi | P98088. |
PTM databases
iPTMneti | P98088. |
UniCarbKBi | P98088. |
Expressioni
Tissue specificityi
Highly expressed in surface mucosal cells of respiratory tract and stomach epithelia. Overexpressed in a number of carcinomas. Also expressed in Barrett's esophagus epithelium and in the proximal duodenum.2 Publications
Gene expression databases
Bgeei | ENSG00000215182. |
Genevisiblei | P98088. HS. |
Organism-specific databases
HPAi | CAB002774. CAB009395. HPA040456. HPA040615. |
Interactioni
Subunit structurei
Multimeric. Interacts with H.pylori in the gastric epithelium, Barrett's esophagus as well as in gastric metaplasia of the duodenum (GMD).1 Publication
Protein-protein interaction databases
IntActi | P98088. 3 interactors. |
STRINGi | 9606.ENSP00000435591. |
Structurei
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5AJN | X-ray | 1.67 | P | 4254-4268 | [»] | |
5AJO | X-ray | 1.48 | B | 2528-2543 | [»] | |
5AJP | X-ray | 1.65 | B | 2528-2543 | [»] | |
ProteinModelPortali | P98088. | |||||
SMRi | P98088. | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 80 – 281 | VWFD 1PROSITE-ProRule annotationAdd BLAST | 202 | |
Domaini | 338 – 394 | TIL 1Sequence analysisAdd BLAST | 57 | |
Domaini | 394 – 465 | VWFC 1PROSITE-ProRule annotationAdd BLAST | 72 | |
Domaini | 433 – 647 | VWFD 2PROSITE-ProRule annotationAdd BLAST | 215 | |
Domaini | 704 – 761 | TIL 2Sequence analysisAdd BLAST | 58 | |
Domaini | 818 – 863 | TIL 3Sequence analysisAdd BLAST | 46 | |
Domaini | 902 – 1109 | VWFD 3PROSITE-ProRule annotationAdd BLAST | 208 | |
Repeati | 1383 – 1481 | Cys-rich subdomain 1Add BLAST | 99 | |
Repeati | 1577 – 1677 | Cys-rich subdomain 2Add BLAST | 101 | |
Repeati | 1743 – 1847 | Cys-rich subdomain 3Add BLAST | 105 | |
Repeati | 1950 – 2050 | Cys-rich subdomain 4Add BLAST | 101 | |
Repeati | 2116 – 2220 | Cys-rich subdomain 5Add BLAST | 105 | |
Repeati | 3222 – 3326 | Cys-rich subdomain 6Add BLAST | 105 | |
Repeati | 3520 – 3660 | Cys-rich subdomain 7Add BLAST | 141 | |
Repeati | 3953 – 4057 | Cys-rich subdomain 8Add BLAST | 105 | |
Repeati | 4627 – 4731 | Cys-rich subdomain 9Add BLAST | 105 | |
Domaini | 4852 – 4918 | VWFC 2PROSITE-ProRule annotationAdd BLAST | 67 | |
Domaini | 4920 – 5131 | VWFD 4PROSITE-ProRule annotationAdd BLAST | 212 | |
Domaini | 5276 – 5345 | VWFC 3PROSITE-ProRule annotationAdd BLAST | 70 | |
Domaini | 5381 – 5448 | VWFC 4PROSITE-ProRule annotationAdd BLAST | 68 | |
Domaini | 5532 – 5620 | CTCKPROSITE-ProRule annotationAdd BLAST | 89 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1383 – 4731 | 9 X Cys-rich subdomain repeatsAdd BLAST | 3349 | |
Regioni | 2257 – 3200 | 107 X 8 AA approximate tandem repeats of T-T-S-T-T-S-A-PAdd BLAST | 944 | |
Regioni | 3363 – 3498 | 17 X 8 AA approximate tandem repeats of T-T-S-T-T-S-A-PAdd BLAST | 136 | |
Regioni | 3661 – 3931 | 34 X 8 AA approximate tandem repeats of T-T-S-T-T-S-A-PAdd BLAST | 271 | |
Regioni | 4093 – 4595 | 58 X 8 AA approximate tandem repeats of T-T-S-T-T-S-A-PAdd BLAST | 503 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1490 – 1585 | Thr-richPROSITE-ProRule annotationAdd BLAST | 96 | |
Compositional biasi | 1681 – 1750 | Thr-richPROSITE-ProRule annotationAdd BLAST | 70 | |
Compositional biasi | 1850 – 1958 | Thr-richPROSITE-ProRule annotationAdd BLAST | 109 | |
Compositional biasi | 2054 – 2124 | Thr-richPROSITE-ProRule annotationAdd BLAST | 71 | |
Compositional biasi | 2223 – 4618 | Thr-richPROSITE-ProRule annotationAdd BLAST | 2396 | |
Compositional biasi | 2231 – 4615 | Ser-richPROSITE-ProRule annotationAdd BLAST | 2385 | |
Compositional biasi | 4750 – 4778 | Ser-richPROSITE-ProRule annotationAdd BLAST | 29 | |
Compositional biasi | 5520 – 5525 | Poly-ProSequence analysis | 6 |
Domaini
The cysteine residues in the Cys-rich subdomain repeats are not involved in disulfide bonding.
Keywords - Domaini
Repeat, SignalPhylogenomic databases
GeneTreei | ENSGT00840000129763. |
InParanoidi | P98088. |
KOi | K21125. |
OMAi | PEATSHV. |
OrthoDBi | EOG091G0006. |
Family and domain databases
InterProi | View protein in InterPro IPR006207. Cys_knot_C. IPR036084. Ser_inhib-like_sf. IPR002919. TIL_dom. IPR014853. Unchr_dom_Cys-rich. IPR001007. VWF_dom. IPR001846. VWF_type-D. IPR025155. WxxW_domain. |
Pfami | View protein in Pfam PF08742. C8. 4 hits. PF13330. Mucin2_WxxW. 9 hits. PF01826. TIL. 3 hits. PF00094. VWD. 4 hits. |
SMARTi | View protein in SMART SM00832. C8. 4 hits. SM00041. CT. 1 hit. SM00214. VWC. 6 hits. SM00215. VWC_out. 2 hits. SM00216. VWD. 4 hits. |
SUPFAMi | SSF57567. SSF57567. 4 hits. |
PROSITEi | View protein in PROSITE PS01185. CTCK_1. 1 hit. PS01225. CTCK_2. 1 hit. PS01208. VWFC_1. 2 hits. PS50184. VWFC_2. 2 hits. PS51233. VWFD. 4 hits. |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P98088-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSVGRRKLAL LWALALALAC TRHTGHAQDG SSESSYKHHP ALSPIARGPS
60 70 80 90 100
GVPLRGATVF PSLRTIPVVR ASNPAHNGRV CSTWGSFHYK TFDGDVFRFP
110 120 130 140 150
GLCNYVFSEH CGAAYEDFNI QLRRSQESAA PTLSRVLMKV DGVVIQLTKG
160 170 180 190 200
SVLVNGHPVL LPFSQSGVLI QQSSSYTKVE ARLGLVLMWN HDDSLLLELD
210 220 230 240 250
TKYANKTCGL CGDFNGMPVV SELLSHNTKL TPMEFGNLQK MDDPTDQCQD
260 270 280 290 300
PVPEPPRNCS TGFGICEELL HGQLFSGCVA LVDVGSYLEA CRQDLCFCED
310 320 330 340 350
TDLLSCVCHT LAEYSRQCTH AGGLPQDWRG PDFCPQKCPN NMQYHECRSP
360 370 380 390 400
CADTCSNQEH SRACEDHCVA GCFCPEGTVL DDIGQTGCVP VSKCACVYNG
410 420 430 440 450
AAYAPGATYS TDCTNCTCSG GRWSCQEVPC PGTCSVLGGA HFSTFDGKQY
460 470 480 490 500
TVHGDCSYVL TKPCDSSAFT VLAELRRCGL TDSETCLKSV TLSLDGAQTV
510 520 530 540 550
VVIKASGEVF LNQIYTQLPI SAANVTIFRP STFFIIAQTS LGLQLNLQLV
560 570 580 590 600
PTMQLFMQLA PKLRGQTCGL CGNFNSIQAD DFRTLSGVVE ATAAAFFNTF
610 620 630 640 650
KTQAACPNIR NSFEDPCSLS VENEKYAQHW CSQLTDADGP FGRCHAAVKP
660 670 680 690 700
GTYYSNCMFD TCNCERSEDC LCAALSSYVH ACAAKGVQLG GWRDGVCTKP
710 720 730 740 750
MTTCPKSMTY HYHVSTCQPT CRSLSEGDIT CSVGFIPVDG CICPKGTFLD
760 770 780 790 800
DTGKCVQASN CPCYHRGSMI PNGESVHDSG AICTCTHGKL SCIGGQAPAP
810 820 830 840 850
VCAAPMVFFD CRNATPGDTG AGCQKSCHTL DMTCYSPQCV PGCVCPDGLV
860 870 880 890 900
ADGEGGCITA EDCPCVHNEA SYRAGQTIRV GCNTCTCDSR MWRCTDDPCL
910 920 930 940 950
ATCAVYGDGH YLTFDGQSYS FNGDCEYTLV QNHCGGKDST QDSFRVVTEN
960 970 980 990 1000
VPCGTTGTTC SKAIKIFLGG FELKLSHGKV EVIGTDESQE VPYTIRQMGI
1010 1020 1030 1040 1050
YLVVDTDIGL VLLWDKKTSI FINLSPEFKG RVCGLCGNFD DIAVNDFATR
1060 1070 1080 1090 1100
SRSVVGDVLE FGNSWKLSPS CPDALAPKDP CTANPFRKSW AQKQCSILHG
1110 1120 1130 1140 1150
PTFAACHAHV EPARYYEACV NDACACDSGG DCECFCTAVA AYAQACHEVG
1160 1170 1180 1190 1200
LCVSWRTPSI CPLFCDYYNP EGQCEWHYQP CGVPCLRTCR NPRGDCLRDV
1210 1220 1230 1240 1250
RGLEGCYPKC PPEAPIFDED KMQCVATCPT PPLPPRCHVH GKSYRPGAVV
1260 1270 1280 1290 1300
PSDKNCQSCL CTERGVECTY KAEACVCTYN GQRFHPGDVI YHTTDGTGGC
1310 1320 1330 1340 1350
ISARCGANGT IERRVYPCSP TTPVPPTTFS FSTPPLVVSS THTPSNGPSS
1360 1370 1380 1390 1400
AHTGPPSSAW PTTAGTSPRT RLPTASASLP PVCGEKCLWS PWMDVSRPGR
1410 1420 1430 1440 1450
GTDSGDFDTL ENLRAHGYRV CESPRSVECR AEDAPGVPLR ALGQRVQCSP
1460 1470 1480 1490 1500
DVGLTCRNRE QASGLCYNYQ IRVQCCTPLP CSTSSSPAQT TPPTTSKTTE
1510 1520 1530 1540 1550
TRASGSSAPS STPGTVSLST ARTTPAPGTA TSVKKTFSTP SPPPVPATST
1560 1570 1580 1590 1600
SSMSTTAPGT SVVSSKPTPT EPSTSSCLQE LCTWTEWIDG SYPAPGINGG
1610 1620 1630 1640 1650
DFDTFQNLRD EGYTFCESPR SVQCRAESFP NTPLADLGQD VICSHTEGLI
1660 1670 1680 1690 1700
CLNKNQLPPI CYNYEIRIQC CETVNVCRDI TRLPKTVATT RPTPHPTGAQ
1710 1720 1730 1740 1750
TQTTFTTHMP SASTEQPTAT SRGGPTATSV TQGTHTTLVT RNCHPRCTWT
1760 1770 1780 1790 1800
KWFDVDFPSP GPHGGDKETY NNIIRSGEKI CRRPEEITRL QCRAKSHPEV
1810 1820 1830 1840 1850
SIEHLGQVVQ CSREEGLVCR NQDQQGPFKM CLNYEVRVLC CETPRGCHMT
1860 1870 1880 1890 1900
STPGSTSSSP AQTTPSTTSK TTETQASGSS APSSTPGTVS LSTARTTPAP
1910 1920 1930 1940 1950
GTATSVKKTF STPSPPPVPA TSTSSMSTTA PGTSVVSSKP TPTEPSTSSC
1960 1970 1980 1990 2000
LQELCTWTEW IDGSYPAPGI NGGDFDTFQN LRDEGYTFCE SPRSVQCRAE
2010 2020 2030 2040 2050
SFPNTPLADL GQDVICSHTE GLICLNKNQL PPICYNYEIR IQCCETVNVC
2060 2070 2080 2090 2100
RDITRPPKTV ATTRPTPHPT GAQTQTTFTT HMPSASTEQP TATSRGGPTA
2110 2120 2130 2140 2150
TSVTQGTHTT PVTRNCHPRC TWTTWFDVDF PSPGPHGGDK ETYNNIIRSG
2160 2170 2180 2190 2200
EKICRRPEEI TRLQCRAKSH PEVSIEHLGQ VVQCSREEGL VCRNQDQQGP
2210 2220 2230 2240 2250
FKMCLNYEVR VLCCETPKGC PVTSTPVTAP STPSGRATSP TQSTSSWQKS
2260 2270 2280 2290 2300
RTTTLVTTST TSTPQTSTTY AHTTSTTSAP TARTTSAPTT RTTSASPAST
2310 2320 2330 2340 2350
TSGPGNTPSP VPTTSTISAP TTSITSAPTT STTSAPTSST TSGPGTTPSP
2360 2370 2380 2390 2400
VPTTSITSAP TTSTTSAPTT STTSARTSST TSATTTSRIS GPETTPSPVP
2410 2420 2430 2440 2450
TTSTTSATTT STTSAPTTST TSAPTSSTTS SPQTSTTSAP TTSTTSGPGT
2460 2470 2480 2490 2500
TPSPVPTTST TSAPTTRTTS APKSSTTSAA TTSTTSGPET TPRPVPTTST
2510 2520 2530 2540 2550
TSSPTTSTTS APTTSTTSAS TTSTTSGAGT TPSPVPTTST TSAPTTSTTS
2560 2570 2580 2590 2600
APISSTTSAT TTSTTSGPGT TPSPVPTTST TSAPTTSTTS GPGTTPSAVP
2610 2620 2630 2640 2650
TTSITSAPTT STNSAPISST TSATTTSRIS GPETTPSPVP TASTTSASTT
2660 2670 2680 2690 2700
STTSGPGTTP SPVPTTSTIS VPTTSTTSAS TTSTTSASTT STTSGPGTTP
2710 2720 2730 2740 2750
SPVPTTSTTS APTTSTTSAP TTSTISAPTT STTSATTTST TSAPTPRRTS
2760 2770 2780 2790 2800
APTTSTISAS TTSTTSATTT STTSATTTST ISAPTTSTTL SPTTSTTSTT
2810 2820 2830 2840 2850
ITSTTSAPIS STTSTPQTST TSAPTTSTTS GPGTTSSPVP TTSTTSAPTT
2860 2870 2880 2890 2900
STTSAPTTRT TSVPTSSTTS TATTSTTSGP GTTPSPVPTT STTSAPTTRT
2910 2920 2930 2940 2950
TSAPTTSTTS APTTSTTSAP TSSTTSATTT STISVPTTST TSVPGTTPSP
2960 2970 2980 2990 3000
VPTTSTISVP TTSTTSASTT STTSGPGTTP SPVPTTSTTS APTTSTTSAP
3010 3020 3030 3040 3050
TTSTISAPTT STPSAPTTST TLAPTTSTTS APTTSTTSTP TSSTTSSPQT
3060 3070 3080 3090 3100
STTSASTTSI TSGPGTTPSP VPTTSTTSAP TTSTTSAATT STISAPTTST
3110 3120 3130 3140 3150
TSAPTTSTTS ASTASKTSGL GTTPSPIPTT STTSPPTTST TSASTASKTS
3160 3170 3180 3190 3200
GPGTTPSPVP TTSTIFAPRT STTSASTTST TPGPGTTPSP VPTTSTASVS
3210 3220 3230 3240 3250
KTSTSHVSIS KTTHSQPVTR DCHLRCTWTK WFDIDFPSPG PHGGDKETYN
3260 3270 3280 3290 3300
NIIRSGEKIC RRPEEITRLQ CRAESHPEVS IEHLGQVVQC SREEGLVCRN
3310 3320 3330 3340 3350
QDQQGPFKMC LNYEVRVLCC ETPKGCPVTS TPVTAPSTPS GRATSPTQST
3360 3370 3380 3390 3400
SSWQKSRTTT LVTTSTTSTP QTSTTSAPTT STTSAPTTST TSAPTTSTTS
3410 3420 3430 3440 3450
TPQTSISSAP TSSTTSAPTS STISARTTSI ISAPTTSTTS SPTTSTTSAT
3460 3470 3480 3490 3500
TTSTTSAPTS STTSTPQTSK TSAATSSTTS GSGTTPSPVT TTSTASVSKT
3510 3520 3530 3540 3550
STSHVSVSKT THSQPVTRDC HPRCTWTKWF DVDFPSPGPH GGDKETYNNI
3560 3570 3580 3590 3600
IRSGEKICRR PEEITRLQCR AKSHPEVSIE HLGQVVQCSR EEGLVCRNQD
3610 3620 3630 3640 3650
QQGPFKMCLN YEVRVLCCET PKGCPVTSTS VTAPSTPSGR ATSPTQSTSS
3660 3670 3680 3690 3700
WQKSRTTTLV TSSITSTTQT STTSAPTTST TPASIPSTTS APTTSTTSAP
3710 3720 3730 3740 3750
TTSTTSAPTT STTSTPQTTT SSAPTSSTTS APTTSTISAP TTSTISAPTT
3760 3770 3780 3790 3800
STTSAPTAST TSAPTSTSSA PTTNTTSAPT TSTTSAPITS TISAPTTSTT
3810 3820 3830 3840 3850
STPQTSTISS PTTSTTSTPQ TSTTSSPTTS TTSAPTTSTT SAPTTSTTST
3860 3870 3880 3890 3900
PQTSISSAPT SSTTSAPTAS TISAPTTSTT SFHTTSTTSP PTSSTSSTPQ
3910 3920 3930 3940 3950
TSKTSAATSS TTSGSGTTPS PVPTTSTASV SKTSTSHVSV SKTTHSQPVT
3960 3970 3980 3990 4000
RDCHPRCTWT KWFDVDFPSP GPHGGDKETY NNIIRSGEKI CRRPEEITRL
4010 4020 4030 4040 4050
QCRAESHPEV SIEHLGQVVQ CSREEGLVCR NQDQQGPFKM CLNYEVRVLC
4060 4070 4080 4090 4100
CETPKGCPVT STPVTAPSTP SGRATSPTQS TSSWQKSRTT TLVTTSTTST
4110 4120 4130 4140 4150
PQTSTTSAPT TSTIPASTPS TTSAPTTSTT SAPTTSTTSA PTHRTTSGPT
4160 4170 4180 4190 4200
TSTTLAPTTS TTSAPTTSTN SAPTTSTISA STTSTISAPT TSTISSPTSS
4210 4220 4230 4240 4250
TTSTPQTSKT SAATSSTTSG SGTTPSPVPT TSTTSASTTS TTSAPTTSTT
4260 4270 4280 4290 4300
SGPGTTPSPV PSTSTTSAAT TSTTSAPTTR TTSAPTSSMT SGPGTTPSPV
4310 4320 4330 4340 4350
PTTSTTSAPT TSTTSGPGTT PSPVPTTSTT SAPITSTTSG PGSTPSPVPT
4360 4370 4380 4390 4400
TSTTSAPTTS TTSASTASTT SGPGTTPSPV PTTSTTSAPT TRTTSASTAS
4410 4420 4430 4440 4450
TTSGPGSTPS PVPTTSTTSA PTTRTTPAST ASTTSGPGTT PSPVPTTSTT
4460 4470 4480 4490 4500
SASTTSTISL PTTSTTSAPI TSMTSGPGTT PSPVPTTSTT SAPTTSTTSA
4510 4520 4530 4540 4550
STASTTSGPG TTPSPVPTTS TTSAPTTSTT SASTASTTSG PGTSLSPVPT
4560 4570 4580 4590 4600
TSTTSAPTTS TTSGPGTTPS PVPTTSTTSA PTTSTTSGPG TTPSPVPTTS
4610 4620 4630 4640 4650
TTPVSKTSTS HLSVSKTTHS QPVTSDCHPL CAWTKWFDVD FPSPGPHGGD
4660 4670 4680 4690 4700
KETYNNIIRS GEKICRRPEE ITRLQCRAES HPEVNIEHLG QVVQCSREEG
4710 4720 4730 4740 4750
LVCRNQDQQG PFKMCLNYEV RVLCCETPRG CPVTSVTPYG TSPTNALYPS
4760 4770 4780 4790 4800
LSTSMVSASV ASTSVASSSV ASSSVAYSTQ TCFCNVADRL YPAGSTIYRH
4810 4820 4830 4840 4850
RDLAGHCYYA LCSQDCQVVR GVDSDCPSTT LPPAPATSPS ISTSEPVTEL
4860 4870 4880 4890 4900
GCPNAVPPRK KGETWATPNC SEATCEGNNV ISLRPRTCPR VEKPTCANGY
4910 4920 4930 4940 4950
PAVKVADQDG CCHHYQCQCV CSGWGDPHYI TFDGTYYTFL DNCTYVLVQQ
4960 4970 4980 4990 5000
IVPVYGHFRV LVDNYFCGAE DGLSCPRSII LEYHQDRVVL TRKPVHGVMT
5010 5020 5030 5040 5050
NEIIFNNKVV SPGFRKNGIV VSRIGVKMYA TIPELGVQVM FSGLIFSVEV
5060 5070 5080 5090 5100
PFSKFANNTE GQCGTCTNDR KDECRTPRGT VVASCSEMSG LWNVSIPDQP
5110 5120 5130 5140 5150
ACHRPHPTPT TVGPTTVGST TVGPTTVGST TVGPTTPPAP CLPSPICQLI
5160 5170 5180 5190 5200
LSKVFEPCHT VIPPLLFYEG CVFDRCHMTD LDVVCSSLEL YAALCASHDI
5210 5220 5230 5240 5250
CIDWRGRTGH MCPFTCPADK VYQPCGPSNP SYCYGNDSAS LGALPEAGPI
5260 5270 5280 5290 5300
TEGCFCPEGM TLFSTSAQVC VPTGCPRCLG PHGEPVKVGH TVGMDCQECT
5310 5320 5330 5340 5350
CEAATWTLTC RPKLCPLPPA CPLPGFVPVP AAPQAGQCCP QYSCACNTSR
5360 5370 5380 5390 5400
CPAPVGCPEG ARAIPTYQEG ACCPVQNCSW TVCSINGTLY QPGAVVSSSL
5410 5420 5430 5440 5450
CETCRCELPG GPPSDAFVVS CETQICNTHC PVGFEYQEQS GQCCGTCVQV
5460 5470 5480 5490 5500
ACVTNTSKSP AHLFYPGETW SDAGNHCVTH QCEKHQDGLV VVTTKKACPP
5510 5520 5530 5540 5550
LSCSLDEARM SKDGCCRFCP PPPPPYQNQS TCAVYHRSLI IQQQGCSSSE
5560 5570 5580 5590 5600
PVRLAYCRGN CGDSSSMYSL EGNTVEHRCQ CCQELRTSLR NVTLHCTDGS
5610 5620 5630 5640 5650
SRAFSYTEVE ECGCMGRRCP APGDTQHSEE AEPEPSQEAE SGSWERGVPV
SPMH
Sequence cautioni
The sequence AAA18431 differs from that shown. Reason: Frameshift at several positions.Curated
The sequence AAA18431 differs from that shown. Reason: Erroneous termination at position 4999. Translated as Met.Curated
The sequence AAC15950 differs from that shown. Reason: Frameshift at positions 24, 44, 671 and 683.Curated
The sequence CAH56330 differs from that shown. Reason: Frameshift at positions 5240, 5247 and 5253.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 25 | G → S in AAC15950 (PubMed:9506983).Curated | 1 | |
Sequence conflicti | 221 | S → R in AAC15950 (PubMed:9506983).Curated | 1 | |
Sequence conflicti | 246 | D → E in CAC83674 (PubMed:11535137).Curated | 1 | |
Sequence conflicti | 246 | D → E in AAC15950 (PubMed:9506983).Curated | 1 | |
Sequence conflicti | 432 | G → D in CAC83674 (PubMed:11535137).Curated | 1 | |
Sequence conflicti | 549 | L → P in CAC83674 (PubMed:11535137).Curated | 1 | |
Sequence conflicti | 658 | M → V in CAC83674 (PubMed:11535137).Curated | 1 | |
Sequence conflicti | 702 | T → I in AAC15950 (PubMed:9506983).Curated | 1 | |
Sequence conflicti | 716 | T → A in AAC15950 (PubMed:9506983).Curated | 1 | |
Sequence conflicti | 817 – 818 | GD → RG in AAC15950 (PubMed:9506983).Curated | 2 | |
Sequence conflicti | 869 | E → K in AAC15950 (PubMed:9506983).Curated | 1 | |
Sequence conflicti | 978 | G → R in AAC15950 (PubMed:9506983).Curated | 1 | |
Sequence conflicti | 996 | R → Q in CAC83674 (PubMed:11535137).Curated | 1 | |
Sequence conflicti | 1141 | A → R in CAA57309 (PubMed:8948439).Curated | 1 | |
Sequence conflicti | 1151 – 1155 | LCVSW → TCVCL in CAA57309 (PubMed:8948439).Curated | 5 | |
Sequence conflicti | 1154 – 1155 | SW → CL in CAC83674 (PubMed:11535137).Curated | 2 | |
Sequence conflicti | 1480 | P → A in CAA57309 (PubMed:8948439).Curated | 1 | |
Sequence conflicti | 1683 | L → P in CAA57309 (PubMed:8948439).Curated | 1 | |
Sequence conflicti | 1738 | L → P in CAA57309 (PubMed:8948439).Curated | 1 | |
Sequence conflicti | 1790 | L → V in CAC83674 (PubMed:11535137).Curated | 1 | |
Sequence conflicti | 1790 | L → V in CAA57309 (PubMed:8948439).Curated | 1 | |
Sequence conflicti | 1803 | E → N AA sequence (PubMed:2656675).Curated | 1 | |
Sequence conflicti | 1874 | T → I in CAC83674 (PubMed:11535137).Curated | 1 | |
Sequence conflicti | 2008 – 2009 | AD → GR in CAC83674 (PubMed:11535137).Curated | 2 | |
Sequence conflicti | 2176 | E → N AA sequence (PubMed:2656675).Curated | 1 | |
Sequence conflicti | 2207 | Y → I in CAC83674 (PubMed:11535137).Curated | 1 | |
Sequence conflicti | 2238 | T → I in CAC83674 (PubMed:11535137).Curated | 1 | |
Sequence conflicti | 2289 – 4237 | Missing in CAC83674 (PubMed:11535137).CuratedAdd BLAST | 1949 | |
Sequence conflicti | 3047 | S → T in CAC83675 (PubMed:11535137).Curated | 1 | |
Sequence conflicti | 3088 | A → S in CAC83676 (PubMed:11535137).Curated | 1 | |
Sequence conflicti | 3095 – 3096 | AP → PL in CAC83676 (PubMed:11535137).Curated | 2 | |
Sequence conflicti | 3105 | T → I in CAC83676 (PubMed:11535137).Curated | 1 | |
Sequence conflicti | 3107 – 4287 | Missing in CAC83676 (PubMed:11535137).CuratedAdd BLAST | 1181 | |
Sequence conflicti | 3234 | I → V in CAC83675 (PubMed:11535137).Curated | 1 | |
Sequence conflicti | 3481 | G → S in CAC83675 (PubMed:11535137).Curated | 1 | |
Sequence conflicti | 3562 | E → Q in CAC83675 (PubMed:11535137).Curated | 1 | |
Sequence conflicti | 3580 | E → N AA sequence (PubMed:2656675).Curated | 1 | |
Sequence conflicti | 3636 – 3644 | TPSGRATSP → PLVGEPPAQ in CAC83675 (PubMed:11535137).Curated | 9 | |
Sequence conflicti | 3817 | S → P in CAC83675 (PubMed:11535137).Curated | 1 | |
Sequence conflicti | 4244 | A → V in CAC83674 (PubMed:11535137).Curated | 1 | |
Sequence conflicti | 4250 – 4254 | TSGPG → ISGPK in CAC83674 (PubMed:11535137).Curated | 5 | |
Sequence conflicti | 4262 | S → T in CAC83674 (PubMed:11535137).Curated | 1 | |
Sequence conflicti | 4265 | T → I in CAC83675 (PubMed:11535137).Curated | 1 | |
Sequence conflicti | 4274 | T → I in CAC83674 (PubMed:11535137).Curated | 1 | |
Sequence conflicti | 4280 – 4284 | RTTSA → STTSV in CAC83674 (PubMed:11535137).Curated | 5 | |
Sequence conflicti | 4286 – 4373 | Missing in CAC83674 (PubMed:11535137).CuratedAdd BLAST | 88 | |
Sequence conflicti | 4290 | T → P in CAC83676 (PubMed:11535137).Curated | 1 | |
Sequence conflicti | 4314 – 4473 | Missing in CAC83676 (PubMed:11535137).CuratedAdd BLAST | 160 | |
Sequence conflicti | 4381 | P → L in CAC83674 (PubMed:11535137).Curated | 1 | |
Sequence conflicti | 4398 – 4400 | TAS → PAG in CAC83674 (PubMed:11535137).Curated | 3 | |
Sequence conflicti | 4407 | S → N in CAC83674 (PubMed:11535137).Curated | 1 | |
Sequence conflicti | 4418 | T → I in CAC83674 (PubMed:11535137).Curated | 1 | |
Sequence conflicti | 4421 – 4484 | Missing in CAC83674 (PubMed:11535137).CuratedAdd BLAST | 64 | |
Sequence conflicti | 4489 | T → I in CAC83674 (PubMed:11535137).Curated | 1 | |
Sequence conflicti | 4501 – 4503 | STA → PTS in CAC83674 (PubMed:11535137).Curated | 3 | |
Sequence conflicti | 4521 | T → I in CAC83674 (PubMed:11535137).Curated | 1 | |
Sequence conflicti | 4533 – 4572 | Missing in CAC83674 (PubMed:11535137).CuratedAdd BLAST | 40 | |
Sequence conflicti | 4588 | G → A in CAC83674 (PubMed:11535137).Curated | 1 | |
Sequence conflicti | 4614 – 4615 | VS → HE in AAA18431 (PubMed:7513696).Curated | 2 | |
Sequence conflicti | 4827 | P → R in CAA88307 (PubMed:7775418).Curated | 1 | |
Sequence conflicti | 4884 | R → S in CAA04737 (PubMed:9620876).Curated | 1 | |
Sequence conflicti | 4884 | R → S in CAA04738 (PubMed:9620876).Curated | 1 | |
Sequence conflicti | 4884 | R → S in CAA88307 (PubMed:7775418).Curated | 1 | |
Sequence conflicti | 4886 | R → P in AAA18431 (PubMed:7513696).Curated | 1 | |
Sequence conflicti | 4899 | G → A in AAA18431 (PubMed:7513696).Curated | 1 | |
Sequence conflicti | 4946 – 4947 | VL → AW in AAA18431 (PubMed:7513696).Curated | 2 | |
Sequence conflicti | 5013 | G → A in CAA88307 (PubMed:7775418).Curated | 1 | |
Sequence conflicti | 5081 – 5084 | VVAS → HASA in AAH33831 (PubMed:15489334).Curated | 4 | |
Sequence conflicti | 5148 | Q → H in CAA88307 (PubMed:7775418).Curated | 1 | |
Sequence conflicti | 5148 | Q → H in AAA18431 (PubMed:7513696).Curated | 1 | |
Sequence conflicti | 5209 – 5210 | GH → RD in AAA18431 (PubMed:7513696).Curated | 2 | |
Sequence conflicti | 5245 | P → R in CAA04737 (PubMed:9620876).Curated | 1 | |
Sequence conflicti | 5245 | P → R in CAA04738 (PubMed:9620876).Curated | 1 | |
Sequence conflicti | 5245 | P → R in AAA18431 (PubMed:7513696).Curated | 1 | |
Sequence conflicti | 5264 | S → T in CAA04737 (PubMed:9620876).Curated | 1 | |
Sequence conflicti | 5264 | S → T in CAA04738 (PubMed:9620876).Curated | 1 | |
Sequence conflicti | 5356 | G → R in AAA18431 (PubMed:7513696).Curated | 1 | |
Sequence conflicti | 5363 | A → R in AAA18431 (PubMed:7513696).Curated | 1 | |
Sequence conflicti | 5433 | G → R in AAA18431 (PubMed:7513696).Curated | 1 | |
Sequence conflicti | 5441 | G → A in AAA18431 (PubMed:7513696).Curated | 1 | |
Sequence conflicti | 5546 | C → S in AAA18431 (PubMed:7513696).Curated | 1 | |
Sequence conflicti | 5622 | P → A in AAA18431 (PubMed:7513696).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_036832 | 5521 | P → L2 PublicationsCorresponds to variant dbSNP:rs1132436Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | FO680660 Genomic DNA. No translation available. FP326773 Genomic DNA. No translation available. KC800812 Genomic DNA. No translation available. AJ298317 mRNA. Translation: CAC83674.1. AJ298318 Genomic DNA. Translation: CAC83675.1. AJ298319 Genomic DNA. Translation: CAC83676.1. AF015521 mRNA. Translation: AAC15950.1. Frameshift. X81649 mRNA. Translation: CAA57309.1. AJ001402 mRNA. Translation: CAA04737.1. AJ001403 Genomic DNA. Translation: CAA04738.1. U06711 mRNA. Translation: AAA18431.1. Sequence problems. Z48314 mRNA. Translation: CAA88307.1. Frameshift. BC033831 mRNA. Translation: AAH33831.1. AL833060 mRNA. Translation: CAH56330.1. Frameshift. |
CCDSi | CCDS76369.1. |
PIRi | A33811. JE0095. |
RefSeqi | NP_001291288.1. NM_001304359.1. |
UniGenei | Hs.534332. Hs.558950. Hs.703588. Hs.703728. Hs.721515. |
Genome annotation databases
Ensembli | ENST00000621226; ENSP00000485659; ENSG00000215182. ENST00000636567; ENSP00000490794; ENSG00000283158. |
GeneIDi | 4586. |
KEGGi | hsa:4586. |
UCSCi | uc031xcx.2. human. |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Entry informationi
Entry namei | MUC5A_HUMAN | |
Accessioni | P98088Primary (citable) accession number: P98088 Secondary accession number(s): A0A096LPK4 Q8WWQ5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1996 |
Last sequence update: | April 1, 2015 | |
Last modified: | March 28, 2018 | |
This is version 162 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |