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P98084 (APBA2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Amyloid beta A4 precursor protein-binding family A member 2
Alternative name(s):
Adapter protein X11beta
Neuron-specific X11L protein
Neuronal Munc18-1-interacting protein 2
Short name=Mint-2
Gene names
Name:Apba2
Synonyms:X11l
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length750 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Putative function in synaptic vesicle exocytosis by binding to STXBP1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the beta-amyloid precursor protein (APP) and hence formation of beta-APP.

Subunit structure

Part of a multimeric complex containing STXBP1 and syntaxin-1. Binds to the cytoplasmic domain of amyloid protein beta, and to the nuclear factor NF-kappa-B/p65 via its PDZ domain. Interacts with the N-terminal domain of APBA2BP By similarity.

Tissue specificity

Specifically expressed in neurons, predominantly of the cerebellum, hippocampus, and spinal cord. Lesser extent in neurons of the cerebral cortex and anterior thalmic nuclei.

Domain

Composed of an N-terminal domain that binds STXBP1, a middle phosphotyrosine-binding domain (PID/PTB) that mediates binding with the cytoplasmic domain of the beta-amyloid precursor protein, and two C-terminal PDZ domains thought to attach proteins to the plasma membrane.

Sequence similarities

Contains 2 PDZ (DHR) domains.

Contains 1 PID domain.

Caution

Was originally (Ref.1) thought to be the ortholog of human X11 (APBA1).

Binary interactions

With

Entry

#Exp.

IntAct

Notes

AppP120232EBI-81669,EBI-78814
PSEN1P497682EBI-81669,EBI-297277From a different organism.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 750750Amyloid beta A4 precursor protein-binding family A member 2
PRO_0000064617

Regions

Domain367 – 556190PID
Domain569 – 65486PDZ 1
Domain660 – 73677PDZ 2
Region185 – 27187STXBP1-binding

Experimental info

Sequence conflict3131K → M in AAA73936. Ref.2
Sequence conflict3881N → T in AAA73936. Ref.2
Sequence conflict4021V → A in AAA73936. Ref.2
Sequence conflict677 – 6793QNG → RW in AAA73936. Ref.2
Sequence conflict688 – 6903GIA → VLQ in AAA73936. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P98084 [UniParc].

Last modified July 19, 2005. Version 2.
Checksum: FC231C966DB467DE

FASTA75082,758
        10         20         30         40         50         60 
MAHRKRQSTA SSMLDHRARP GPIPHDQEPE SEDTELPLES YVPTGLELGT LRPESPTPEE 

        70         80         90        100        110        120 
QECHNHSPDG DSSSDYVNNT SEEEDYDEGL PEEEEGVTYY IRYCPEDDSY LEGMDCNGEE 

       130        140        150        160        170        180 
YIAHGAHPVD TDECQEAVED WTDSVGPHTH SHGAENSQEY PDGHLPIPED DPTVLEVHDQ 

       190        200        210        220        230        240 
EEDGHYCSSK ESYQDYYPPE TNGNTGGASP YRMRRGDGDL EEQEEDIDQI VAEIKMSLSM 

       250        260        270        280        290        300 
TSITSASEAS PEHMPELDPG DSTEACPPSD TGHGPGRQEA RPKSLNLPPE VKHPGDLQRG 

       310        320        330        340        350        360 
LKTKTRTPEE RPKWPQEQVC NGLEQPRKQQ RSDLNGPTDN NNIPETKKVA SFPSFVAVPG 

       370        380        390        400        410        420 
PCEAEDLIDG IIFAANYLGS TQLLSERNPS KNIRMMQAQE AVSRVKRMQK AAKIKKKANS 

       430        440        450        460        470        480 
EGDAQTLTEV DLFISTQRIK VLNADTQETM MDHALRTISY IADIGNIVVL MARRRMPRSA 

       490        500        510        520        530        540 
SQDCIETTPG AQEGKKQYKM ICHVFESEDA QLIAQSIGQA FSVAYQEFLR ANGINPEDLS 

       550        560        570        580        590        600 
QKEYSDIINT QEMYNDDLIH FSNSENCKEL QLEKHKGEIL GVVVVESGWG SILPTVILAN 

       610        620        630        640        650        660 
MMNGGPAARS GKLSIGDQIM SINGTSLVGL PLATCQGIIK GLKNQTQVKL NIVSCPPVTT 

       670        680        690        700        710        720 
VLIKRPDLKY QLGFSVQNGI ICSLMRGGIA ERGGVRVGHR IIEINGQSVV ATAHEKIVQA 

       730        740        750 
LSNSVGEIHM KTMPAAMFRL LTGQETPLYI 

« Hide

References

« Hide 'large scale' references
[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
Tissue: Brain.
[2]"Comparison of primary structure of a neuron-specific protein, X11, between human and mouse."
Duclos F., Koenig M.
Mamm. Genome 6:57-58(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 70-750.
Tissue: Brain.
[3]"Phosphoproteomic analysis of the developing mouse brain."
Ballif B.A., Villen J., Beausoleil S.A., Schwartz D., Gygi S.P.
Mol. Cell. Proteomics 3:1093-1101(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Embryonic brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC060269 mRNA. Translation: AAH60269.1.
BC057620 mRNA. Translation: AAH57620.1.
L34676 mRNA. Translation: AAA73936.1.
RefSeqNP_031487.1. NM_007461.2.
XP_006540635.1. XM_006540572.1.
XP_006540636.1. XM_006540573.1.
XP_006540637.1. XM_006540574.1.
XP_006540638.1. XM_006540575.1.
UniGeneMm.4657.

3D structure databases

ProteinModelPortalP98084.
SMRP98084. Positions 364-750.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP98084. 5 interactions.

PTM databases

PhosphoSiteP98084.

Proteomic databases

PaxDbP98084.
PRIDEP98084.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000032732; ENSMUSP00000032732; ENSMUSG00000030519.
GeneID11784.
KEGGmmu:11784.
UCSCuc009hgj.2. mouse.

Organism-specific databases

CTD321.
MGIMGI:1261791. Apba2.

Phylogenomic databases

eggNOGNOG283022.
GeneTreeENSGT00390000013578.
HOGENOMHOG000033981.
HOVERGENHBG050523.
InParanoidP98084.
OMARHEGRPK.
OrthoDBEOG78PV8H.
TreeFamTF315245.

Gene expression databases

ArrayExpressP98084.
BgeeP98084.
GenevestigatorP98084.

Family and domain databases

Gene3D2.30.29.30. 1 hit.
InterProIPR001478. PDZ.
IPR011993. PH_like_dom.
IPR006020. PTB/PI_dom.
[Graphical view]
PfamPF00595. PDZ. 2 hits.
PF00640. PID. 1 hit.
[Graphical view]
SMARTSM00228. PDZ. 2 hits.
SM00462. PTB. 1 hit.
[Graphical view]
SUPFAMSSF50156. SSF50156. 2 hits.
PROSITEPS50106. PDZ. 2 hits.
PS01179. PID. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSAPBA2. mouse.
NextBio279597.
PROP98084.
SOURCESearch...

Entry information

Entry nameAPBA2_MOUSE
AccessionPrimary (citable) accession number: P98084
Secondary accession number(s): Q6PAJ2
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: July 19, 2005
Last modified: March 19, 2014
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot