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P98084

- APBA2_MOUSE

UniProt

P98084 - APBA2_MOUSE

Protein

Amyloid beta A4 precursor protein-binding family A member 2

Gene

Apba2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 2 (19 Jul 2005)
      Previous versions | rss
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    Functioni

    Putative function in synaptic vesicle exocytosis by binding to STXBP1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the beta-amyloid precursor protein (APP) and hence formation of beta-APP.

    GO - Molecular functioni

    1. beta-amyloid binding Source: Ensembl
    2. protein binding Source: IntAct

    GO - Biological processi

    1. in utero embryonic development Source: MGI
    2. locomotory behavior Source: MGI
    3. multicellular organism growth Source: MGI
    4. protein transport Source: UniProtKB-KW
    5. regulation of gene expression Source: MGI
    6. synaptic transmission Source: MGI

    Keywords - Biological processi

    Protein transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Amyloid beta A4 precursor protein-binding family A member 2
    Alternative name(s):
    Adapter protein X11beta
    Neuron-specific X11L protein
    Neuronal Munc18-1-interacting protein 2
    Short name:
    Mint-2
    Gene namesi
    Name:Apba2
    Synonyms:X11l
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:1261791. Apba2.

    Subcellular locationi

    GO - Cellular componenti

    1. plasma membrane Source: Ensembl

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 750750Amyloid beta A4 precursor protein-binding family A member 2PRO_0000064617Add
    BLAST

    Proteomic databases

    MaxQBiP98084.
    PaxDbiP98084.
    PRIDEiP98084.

    PTM databases

    PhosphoSiteiP98084.

    Expressioni

    Tissue specificityi

    Specifically expressed in neurons, predominantly of the cerebellum, hippocampus, and spinal cord. Lesser extent in neurons of the cerebral cortex and anterior thalmic nuclei.

    Gene expression databases

    BgeeiP98084.
    GenevestigatoriP98084.

    Interactioni

    Subunit structurei

    Part of a multimeric complex containing STXBP1 and syntaxin-1. Binds to the cytoplasmic domain of amyloid protein beta, and to the nuclear factor NF-kappa-B/p65 via its PDZ domain. Interacts with the N-terminal domain of APBA2BP By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    AppP120232EBI-81669,EBI-78814
    PSEN1P497682EBI-81669,EBI-297277From a different organism.

    Protein-protein interaction databases

    IntActiP98084. 5 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliP98084.
    SMRiP98084. Positions 364-750.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini367 – 556190PIDPROSITE-ProRule annotationAdd
    BLAST
    Domaini569 – 65486PDZ 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini660 – 73677PDZ 2PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni185 – 27187STXBP1-bindingAdd
    BLAST

    Domaini

    Composed of an N-terminal domain that binds STXBP1, a middle phosphotyrosine-binding domain (PID/PTB) that mediates binding with the cytoplasmic domain of the beta-amyloid precursor protein, and two C-terminal PDZ domains thought to attach proteins to the plasma membrane.

    Sequence similaritiesi

    Contains 2 PDZ (DHR) domains.PROSITE-ProRule annotation
    Contains 1 PID domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG283022.
    GeneTreeiENSGT00390000013578.
    HOGENOMiHOG000033981.
    HOVERGENiHBG050523.
    InParanoidiP98084.
    OMAiRHEGRPK.
    OrthoDBiEOG78PV8H.
    PhylomeDBiP98084.
    TreeFamiTF315245.

    Family and domain databases

    Gene3Di2.30.29.30. 1 hit.
    2.30.42.10. 2 hits.
    InterProiIPR001478. PDZ.
    IPR011993. PH_like_dom.
    IPR006020. PTB/PI_dom.
    [Graphical view]
    PfamiPF00595. PDZ. 2 hits.
    PF00640. PID. 1 hit.
    [Graphical view]
    SMARTiSM00228. PDZ. 2 hits.
    SM00462. PTB. 1 hit.
    [Graphical view]
    SUPFAMiSSF50156. SSF50156. 2 hits.
    PROSITEiPS50106. PDZ. 2 hits.
    PS01179. PID. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P98084-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAHRKRQSTA SSMLDHRARP GPIPHDQEPE SEDTELPLES YVPTGLELGT    50
    LRPESPTPEE QECHNHSPDG DSSSDYVNNT SEEEDYDEGL PEEEEGVTYY 100
    IRYCPEDDSY LEGMDCNGEE YIAHGAHPVD TDECQEAVED WTDSVGPHTH 150
    SHGAENSQEY PDGHLPIPED DPTVLEVHDQ EEDGHYCSSK ESYQDYYPPE 200
    TNGNTGGASP YRMRRGDGDL EEQEEDIDQI VAEIKMSLSM TSITSASEAS 250
    PEHMPELDPG DSTEACPPSD TGHGPGRQEA RPKSLNLPPE VKHPGDLQRG 300
    LKTKTRTPEE RPKWPQEQVC NGLEQPRKQQ RSDLNGPTDN NNIPETKKVA 350
    SFPSFVAVPG PCEAEDLIDG IIFAANYLGS TQLLSERNPS KNIRMMQAQE 400
    AVSRVKRMQK AAKIKKKANS EGDAQTLTEV DLFISTQRIK VLNADTQETM 450
    MDHALRTISY IADIGNIVVL MARRRMPRSA SQDCIETTPG AQEGKKQYKM 500
    ICHVFESEDA QLIAQSIGQA FSVAYQEFLR ANGINPEDLS QKEYSDIINT 550
    QEMYNDDLIH FSNSENCKEL QLEKHKGEIL GVVVVESGWG SILPTVILAN 600
    MMNGGPAARS GKLSIGDQIM SINGTSLVGL PLATCQGIIK GLKNQTQVKL 650
    NIVSCPPVTT VLIKRPDLKY QLGFSVQNGI ICSLMRGGIA ERGGVRVGHR 700
    IIEINGQSVV ATAHEKIVQA LSNSVGEIHM KTMPAAMFRL LTGQETPLYI 750
    Length:750
    Mass (Da):82,758
    Last modified:July 19, 2005 - v2
    Checksum:iFC231C966DB467DE
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti313 – 3131K → M in AAA73936. (PubMed:7719031)Curated
    Sequence conflicti388 – 3881N → T in AAA73936. (PubMed:7719031)Curated
    Sequence conflicti402 – 4021V → A in AAA73936. (PubMed:7719031)Curated
    Sequence conflicti677 – 6793QNG → RW in AAA73936. (PubMed:7719031)Curated
    Sequence conflicti688 – 6903GIA → VLQ in AAA73936. (PubMed:7719031)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC060269 mRNA. Translation: AAH60269.1.
    BC057620 mRNA. Translation: AAH57620.1.
    L34676 mRNA. Translation: AAA73936.1.
    CCDSiCCDS21335.1.
    RefSeqiNP_001278095.1. NM_001291166.1.
    NP_001278096.1. NM_001291167.1.
    NP_031487.1. NM_007461.2.
    XP_006540636.1. XM_006540573.1.
    XP_006540637.1. XM_006540574.1.
    UniGeneiMm.4657.

    Genome annotation databases

    EnsembliENSMUST00000032732; ENSMUSP00000032732; ENSMUSG00000030519.
    GeneIDi11784.
    KEGGimmu:11784.
    UCSCiuc009hgj.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC060269 mRNA. Translation: AAH60269.1 .
    BC057620 mRNA. Translation: AAH57620.1 .
    L34676 mRNA. Translation: AAA73936.1 .
    CCDSi CCDS21335.1.
    RefSeqi NP_001278095.1. NM_001291166.1.
    NP_001278096.1. NM_001291167.1.
    NP_031487.1. NM_007461.2.
    XP_006540636.1. XM_006540573.1.
    XP_006540637.1. XM_006540574.1.
    UniGenei Mm.4657.

    3D structure databases

    ProteinModelPortali P98084.
    SMRi P98084. Positions 364-750.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P98084. 5 interactions.

    PTM databases

    PhosphoSitei P98084.

    Proteomic databases

    MaxQBi P98084.
    PaxDbi P98084.
    PRIDEi P98084.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000032732 ; ENSMUSP00000032732 ; ENSMUSG00000030519 .
    GeneIDi 11784.
    KEGGi mmu:11784.
    UCSCi uc009hgj.2. mouse.

    Organism-specific databases

    CTDi 321.
    MGIi MGI:1261791. Apba2.

    Phylogenomic databases

    eggNOGi NOG283022.
    GeneTreei ENSGT00390000013578.
    HOGENOMi HOG000033981.
    HOVERGENi HBG050523.
    InParanoidi P98084.
    OMAi RHEGRPK.
    OrthoDBi EOG78PV8H.
    PhylomeDBi P98084.
    TreeFami TF315245.

    Miscellaneous databases

    ChiTaRSi APBA2. mouse.
    NextBioi 279597.
    PROi P98084.
    SOURCEi Search...

    Gene expression databases

    Bgeei P98084.
    Genevestigatori P98084.

    Family and domain databases

    Gene3Di 2.30.29.30. 1 hit.
    2.30.42.10. 2 hits.
    InterProi IPR001478. PDZ.
    IPR011993. PH_like_dom.
    IPR006020. PTB/PI_dom.
    [Graphical view ]
    Pfami PF00595. PDZ. 2 hits.
    PF00640. PID. 1 hit.
    [Graphical view ]
    SMARTi SM00228. PDZ. 2 hits.
    SM00462. PTB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50156. SSF50156. 2 hits.
    PROSITEi PS50106. PDZ. 2 hits.
    PS01179. PID. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain.
    2. "Comparison of primary structure of a neuron-specific protein, X11, between human and mouse."
      Duclos F., Koenig M.
      Mamm. Genome 6:57-58(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 70-750.
      Tissue: Brain.
    3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic brain.

    Entry informationi

    Entry nameiAPBA2_MOUSE
    AccessioniPrimary (citable) accession number: P98084
    Secondary accession number(s): Q6PAJ2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: July 19, 2005
    Last modified: October 1, 2014
    This is version 102 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Caution

    Was originally thought to be the ortholog of human X11 (APBA1).1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3