##gff-version 3 P98078 UniProtKB Initiator methionine 1 1 . . . Note=Removed;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P98082 P98078 UniProtKB Chain 2 766 . . . ID=PRO_0000079771;Note=Disabled homolog 2 P98078 UniProtKB Domain 45 196 . . . Note=PID;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00148 P98078 UniProtKB Region 1 36 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P98078 UniProtKB Region 230 447 . . . Note=Required for localization to clathrin-coated pits P98078 UniProtKB Region 284 482 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P98078 UniProtKB Region 596 630 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P98078 UniProtKB Region 600 730 . . . Note=Sufficient for interaction with GRB2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9569023;Dbxref=PMID:9569023 P98078 UniProtKB Region 617 625 . . . Note=Required for interaction with CSK;Ontology_term=ECO:0000250;evidence=ECO:0000250 P98078 UniProtKB Region 647 766 . . . Note=Required for interaction with MYO6;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11906161;Dbxref=PMID:11906161 P98078 UniProtKB Region 659 683 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P98078 UniProtKB Region 661 669 . . . Note=Required for interaction with GRB2 and CSK;Ontology_term=ECO:0000250;evidence=ECO:0000250 P98078 UniProtKB Region 699 766 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P98078 UniProtKB Region 707 723 . . . Note=Sufficient for interaction with SH3KBP1 SH3 domain P98078 UniProtKB Motif 293 295 . . . Note=DPF 1 P98078 UniProtKB Motif 298 300 . . . Note=DPF 2 P98078 UniProtKB Compositional bias 1 18 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P98078 UniProtKB Compositional bias 21 36 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P98078 UniProtKB Compositional bias 303 356 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P98078 UniProtKB Compositional bias 364 394 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P98078 UniProtKB Compositional bias 412 430 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P98078 UniProtKB Compositional bias 441 455 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P98078 UniProtKB Compositional bias 463 477 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P98078 UniProtKB Compositional bias 596 612 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P98078 UniProtKB Compositional bias 613 627 . . . Note=Pro residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P98078 UniProtKB Compositional bias 724 757 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P98078 UniProtKB Modified residue 2 2 . . . Note=N-acetylserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P98082 P98078 UniProtKB Modified residue 2 2 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O88797 P98078 UniProtKB Modified residue 170 170 . . . Note=Phosphotyrosine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:21183079;Dbxref=PMID:21183079 P98078 UniProtKB Modified residue 193 193 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:21183079;Dbxref=PMID:21183079 P98078 UniProtKB Modified residue 323 323 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19144319;Dbxref=PMID:19144319 P98078 UniProtKB Modified residue 326 326 . . . Note=Phosphoserine%3B in mitosis;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O88797 P98078 UniProtKB Modified residue 328 328 . . . Note=Phosphoserine%3B in mitosis;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O88797 P98078 UniProtKB Modified residue 401 401 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P98082 P98078 UniProtKB Modified residue 671 671 . . . Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:21183079;Dbxref=PMID:21183079 P98078 UniProtKB Modified residue 727 727 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:19144319,ECO:0007744|PubMed:21183079;Dbxref=PMID:19144319,PMID:21183079 P98078 UniProtKB Modified residue 759 759 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:21183079;Dbxref=PMID:21183079 P98078 UniProtKB Alternative sequence 209 229 . . . ID=VSP_004182;Note=In isoform p93. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7775479;Dbxref=PMID:7775479 P98078 UniProtKB Alternative sequence 230 447 . . . ID=VSP_004183;Note=In isoform p67. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:7775479;Dbxref=PMID:15489334,PMID:7775479 P98078 UniProtKB Mutagenesis 53 53 . . . Note=Abolishes binding to PtdIns(4%2C5)P2. K->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12826668,ECO:0000269|PubMed:16984970;Dbxref=PMID:12826668,PMID:16984970 P98078 UniProtKB Mutagenesis 53 53 . . . Note=Abolishes LDLR endocytosis. K->Q;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12826668,ECO:0000269|PubMed:16984970;Dbxref=PMID:12826668,PMID:16984970 P98078 UniProtKB Mutagenesis 90 90 . . . Note=Abolishes binding to PtdIns(4%2C5)P2. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12826668;Dbxref=PMID:12826668 P98078 UniProtKB Mutagenesis 122 122 . . . Note=Abolishes LDLR endocytosis. S->T;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16870701,ECO:0000269|PubMed:16984970;Dbxref=PMID:16870701,PMID:16984970 P98078 UniProtKB Mutagenesis 122 122 . . . Note=Impairs LDLR endocytosis. S->Y;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16870701,ECO:0000269|PubMed:16984970;Dbxref=PMID:16870701,PMID:16984970 P98078 UniProtKB Mutagenesis 255 255 . . . Note=Abolishes interaction with ITSN1%2C fails to internalize integrin beta-1%3B when associated with V-398%2C V-589%2C V-736 and V-765. F->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22648170;Dbxref=PMID:22648170 P98078 UniProtKB Mutagenesis 294 294 . . . Note=Loss of interaction with FCHO2%3B when associated with A-299. P->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22323290;Dbxref=PMID:22323290 P98078 UniProtKB Mutagenesis 299 299 . . . Note=Loss of interaction with FCHO2%3B when associated with A-294. P->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22323290;Dbxref=PMID:22323290 P98078 UniProtKB Mutagenesis 398 398 . . . Note=Abolishes interaction with ITSN1%2C fails to internalize integrin beta-1%3B when associated with V-255%2C V-589%2C V-736 and V-765. F->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22648170;Dbxref=PMID:22648170 P98078 UniProtKB Mutagenesis 589 589 . . . Note=Abolishes interaction with EPS15 and impairs interaction with ITSN1%2C fails to internalize integrin beta-1%3B when associated with V-736 and V-765. Abolishes interaction with ITSN1%3B when associated with V-255%2C V-398%2C V-736 and V-765. F->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22648170;Dbxref=PMID:22648170 P98078 UniProtKB Mutagenesis 736 736 . . . Note=Abolishes interaction with EPS15 and impairs interaction with ITSN1%2C fails to internalize integrin beta-1%3B when associated with V-589 and V-765. Abolishes interaction with ITSN1%3B when associated with V-255%2C V-398%2C V-589%2C and V-765. F->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22648170;Dbxref=PMID:22648170 P98078 UniProtKB Mutagenesis 765 765 . . . Note=Abolishes interaction with EPS15 and impairs interaction with ITSN1%2C fails to internalize integrin beta-1%3B when associated with V-589 and V-736. Abolishes interaction with ITSN1%3B when associated with V-255%2C V-398%2C V-589 and V-736. F->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22648170;Dbxref=PMID:22648170 P98078 UniProtKB Sequence conflict 10 10 . . . Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305 P98078 UniProtKB Sequence conflict 224 224 . . . Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 P98078 UniProtKB Sequence conflict 338 338 . . . Note=G->V;Ontology_term=ECO:0000305;evidence=ECO:0000305 P98078 UniProtKB Sequence conflict 454 454 . . . Note=L->P;Ontology_term=ECO:0000305;evidence=ECO:0000305 P98078 UniProtKB Sequence conflict 490 490 . . . Note=A->P;Ontology_term=ECO:0000305;evidence=ECO:0000305 P98078 UniProtKB Sequence conflict 536 536 . . . Note=R->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 P98078 UniProtKB Sequence conflict 553 553 . . . Note=S->P;Ontology_term=ECO:0000305;evidence=ECO:0000305 P98078 UniProtKB Helix 36 43 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1P3R P98078 UniProtKB Beta strand 48 63 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1P3R P98078 UniProtKB Helix 66 84 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1P3R P98078 UniProtKB Turn 85 87 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1P3R P98078 UniProtKB Beta strand 91 98 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1P3R P98078 UniProtKB Beta strand 101 106 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1P3R P98078 UniProtKB Turn 107 109 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1P3R P98078 UniProtKB Beta strand 112 116 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1P3R P98078 UniProtKB Helix 118 120 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1P3R P98078 UniProtKB Beta strand 121 126 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1P3R P98078 UniProtKB Beta strand 133 140 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1P3R P98078 UniProtKB Beta strand 144 153 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1P3R P98078 UniProtKB Helix 156 177 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1P3R