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P98077 (SHC2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 117. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
SHC-transforming protein 2
Alternative name(s):
Protein Sck
SHC-transforming protein B
Src homology 2 domain-containing-transforming protein C2
Short name=SH2 domain protein C2
Gene names
Name:SHC2
Synonyms:SCK, SHCB
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length582 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons By similarity.

Subunit structure

Interacts with the Trk receptors in a phosphotyrosine-dependent manner and MEGF12. Once activated, binds to GRB2. Ref.2 Ref.6 Ref.7

Tissue specificity

Expressed in brain. Expressed at high level in the hypothalamus and at low level in the caudate nucleus. Ref.2

Domain

The PID domain mediates binding to the TrkA receptor.

Post-translational modification

Phosphorylated on tyrosines by the Trk receptors. Ref.6

Miscellaneous

Ref.1 has shown that SHC2 is poorly phosphorylated by the Trk receptors, in opposite to Ref.6.

Sequence similarities

Contains 1 PID domain.

Contains 1 SH2 domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 582582SHC-transforming protein 2
PRO_0000097732

Regions

Domain147 – 329183PID
Domain487 – 57892SH2
Region330 – 486157CH1

Amino acid modifications

Modified residue3381Phosphotyrosine Probable
Modified residue3391Phosphotyrosine Probable
Modified residue4141Phosphotyrosine Probable

Experimental info

Sequence conflict45 – 5612GRGPA…RAAGA → IRGSNAQKVVGASG in BAA25798. Ref.2
Sequence conflict611D → G in BAA25798. Ref.2
Sequence conflict651E → D in BAA25798. Ref.2
Sequence conflict96 – 12530LSRCR…AAAEW → MAFAGLASHVWWWRPSSQNR IWFRRGSPEF Ref.3
Sequence conflict1141A → P Ref.4
Sequence conflict1881E → I Ref.3
Sequence conflict2261I → T Ref.3
Sequence conflict2721I → E Ref.3
Sequence conflict4401Missing Ref.3

Sequences

Sequence LengthMass (Da)Tools
P98077 [UniParc].

Last modified July 1, 2008. Version 4.
Checksum: F640AC298DA37B68

FASTA58261,916
        10         20         30         40         50         60 
MTQGPGGRAP PAPPAPPEPE APTTFCALLP RMPQWKFAAP GGFLGRGPAA ARAAGASGGA 

        70         80         90        100        110        120 
DPQPEPAGPG GVPALAAAVL GACEPRCAAP CPLPALSRCR GAGSRGSRGG RGAAGSGDAA 

       130        140        150        160        170        180 
AAAEWIRKGS FIHKPAHGWL HPDARVLGPG VSYVVRYMGC IEVLRSMRSL DFNTRTQVTR 

       190        200        210        220        230        240 
EAINRLHEAV PGVRGSWKKK APNKALASVL GKSNLRFAGM SISIHISTDG LSLSVPATRQ 

       250        260        270        280        290        300 
VIANHHMPSI SFASGGDTDM TDYVAYVAKD PINQRACHIL ECCEGLAQSI ISTVGQAFEL 

       310        320        330        340        350        360 
RFKQYLHSPP KVALPPERLA GPEESAWGDE EDSLEHNYYN SIPGKEPPLG GLVDSRLALT 

       370        380        390        400        410        420 
QPCALTALDQ GPSPSLRDAC SLPWDVGSTG TAPPGDGYVQ ADARGPPDHE EHLYVNTQGL 

       430        440        450        460        470        480 
DAPEPEDSPK KDLFDMRPFE DALKLHECSV AAGVTAAPLP LEDQWPSPPT RRAPVAPTEE 

       490        500        510        520        530        540 
QLRQEPWYHG RMSRRAAERM LRADGDFLVR DSVTNPGQYV LTGMHAGQPK HLLLVDPEGV 

       550        560        570        580 
VRTKDVLFES ISHLIDHHLQ NGQPIVAAES ELHLRGVVSR EP 

« Hide

References

« Hide 'large scale' references
[1]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"N-Shc and Sck, two neuronally expressed Shc adapter homologs. Their differential regional expression in the brain and roles in neurotrophin and Src signaling."
Nakamura T., Muraoka S., Sanokawa R., Mori N.
J. Biol. Chem. 273:6960-6967(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 45-582, INTERACTION WITH THE TRK RECEPTORS, TISSUE SPECIFICITY.
[3]"A family of Shc related proteins with conserved PTB, CH1 and SH2 regions."
Pelicci G., Dente L., De Giuseppe A., Verducci-Galletti B., Giuli S., Mele S., Vetriani C., Giorgio M., Pandolfi P.P., Cesareni G., Pelicci P.-G.
Oncogene 13:633-641(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 96-582.
Tissue: Fetal brain.
[4]"An alternative to SH2 domains for binding tyrosine-phosphorylated proteins."
Kavanaugh W.M., Williams L.T.
Science 266:1862-1865(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 114-541.
[5]The European IMAGE consortium
Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 191-582.
[6]"ShcB and ShcC activation by the Trk family of receptor tyrosine kinases."
Liu H.Y., Meakin S.O.
J. Biol. Chem. 277:26046-26056(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION, INTERACTION WITH THE TRK RECEPTORS.
[7]"Platelet endothelial aggregation receptor 1 (PEAR1), a novel epidermal growth factor repeat-containing transmembrane receptor, participates in platelet contact-induced activation."
Nanda N., Bao M., Lin H., Clauser K., Komuves L., Quertermous T., Conley P.B., Phillips D.R., Hart M.J.
J. Biol. Chem. 280:24680-24689(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH MEGF12.
Tissue: Platelet.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC008988 Genomic DNA. No translation available.
AC138433 Genomic DNA. No translation available.
AC006124 Genomic DNA. No translation available.
AB001451 mRNA. Translation: BAA25798.1.
AL360254 mRNA. Translation: CAB96175.1.
CCDSCCDS45891.1.
RefSeqNP_036567.2. NM_012435.2.
UniGeneHs.30965.

3D structure databases

ProteinModelPortalP98077.
SMRP98077. Positions 124-306, 480-581.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid117302. 5 interactions.
IntActP98077. 5 interactions.
MINTMINT-127694.
STRING9606.ENSP00000264554.

Chemistry

BindingDBP98077.
ChEMBLCHEMBL3299.

PTM databases

PhosphoSiteP98077.

Polymorphism databases

DMDM193806386.

Proteomic databases

PaxDbP98077.
PRIDEP98077.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000264554; ENSP00000264554; ENSG00000129946.
GeneID25759.
KEGGhsa:25759.
UCSCuc002loq.4. human.

Organism-specific databases

CTD25759.
GeneCardsGC19M000369.
H-InvDBHIX0027436.
HGNCHGNC:29869. SHC2.
HPAHPA006136.
MIM605217. gene.
neXtProtNX_P98077.
PharmGKBPA134971076.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG315087.
HOGENOMHOG000231974.
HOVERGENHBG050121.
InParanoidP98077.
KOK17447.
OMAGACEPRC.
OrthoDBEOG7MD4QK.
PhylomeDBP98077.
TreeFamTF315807.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.
SignaLinkP98077.

Gene expression databases

ArrayExpressP98077.
BgeeP98077.
CleanExHS_SHC2.
GenevestigatorP98077.

Family and domain databases

Gene3D2.30.29.30. 1 hit.
3.30.505.10. 1 hit.
InterProIPR011993. PH_like_dom.
IPR006019. PID_Shc-like.
IPR006020. PTB/PI_dom.
IPR000980. SH2.
[Graphical view]
PfamPF00640. PID. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view]
PRINTSPR00401. SH2DOMAIN.
PR00629. SHCPIDOMAIN.
SMARTSM00462. PTB. 1 hit.
SM00252. SH2. 1 hit.
[Graphical view]
SUPFAMSSF55550. SSF55550. 1 hit.
PROSITEPS01179. PID. 1 hit.
PS50001. SH2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiSHC2.
GenomeRNAi25759.
NextBio46868.
PROP98077.
SOURCESearch...

Entry information

Entry nameSHC2_HUMAN
AccessionPrimary (citable) accession number: P98077
Secondary accession number(s): O60230, Q9NPL5, Q9UCX4
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: July 1, 2008
Last modified: July 9, 2014
This is version 117 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM