Reviewed,
UniProtKB/Swiss-Prot P98077 (SHC2_HUMAN)
Last modified
November 25, 2008.
Version 65.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: SHC-transforming protein 2 Alternative name(s): Src homology 2 domain-containing-transforming protein C2 Short name=SH2 domain protein C2 Protein Sck | ||||
| Gene names |
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| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 582 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons By similarity. |
| Subunit structure | Interacts with the Trk receptors in a phosphotyrosine-dependent manner and MEGF12. Once activated, binds to GRB2. |
| Tissue specificity | Expressed in brain. Expressed at high level in the hypothalamus and at low level in the caudate nucleus. |
| Domain | The PID domain mediates binding to the TrkA receptor. |
| Post-translational modification | Phosphorylated on tyrosines by the Trk receptors. |
| Miscellaneous | Ref.1 has shown that SHC2 is poorly phosphorylated by the Trk receptors, in opposite to Ref.6. |
| Sequence similarities | Contains 1 PID domain. Contains 1 SH2 domain. |
Ontologies
Keywords | |
|---|---|
| Domain | SH2 domain |
| PTM | Phosphoprotein |
Gene Ontology (GO) | |
| Biological process | Ras protein signal transduction Inferred from Experiment. Source: Reactome |
| Cellular component | cytoplasm Inferred from direct assay. Source: HPA |
| Molecular function | protein binding Ref.4 Traceable author statement. Source: UniProtKB |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 582 | 582 | SHC-transforming protein 2 | PRO_0000097732 | |||||
Regions | |||||||||
| Domain | 147 – 329 | 183 | PID | ||||||
| Domain | 487 – 578 | 92 | SH2 | ||||||
| Region | 330 – 486 | 157 | CH1 | ||||||
Amino acid modifications | |||||||||
| Modified residue | 338 | 1 | Phosphotyrosine Probable | ||||||
| Modified residue | 339 | 1 | Phosphotyrosine Probable | ||||||
| Modified residue | 414 | 1 | Phosphotyrosine Probable | ||||||
Experimental info | |||||||||
| Sequence conflict | 45 – 56 | 12 | GRGPA…RAAGA → IRGSNAQKVVGASG in BAA25798. Ref.2 | ||||||
| Sequence conflict | 61 | 1 | D → G in BAA25798. Ref.2 | ||||||
| Sequence conflict | 65 | 1 | E → D in BAA25798. Ref.2 | ||||||
| Sequence conflict | 96 – 125 | 30 | LSRCR…AAAEW → MAFAGLASHVWWWRPSSQNR IWFRRGSPEF Ref.3 | ||||||
| Sequence conflict | 114 | 1 | A → P Ref.4 | ||||||
| Sequence conflict | 188 | 1 | E → I Ref.3 | ||||||
| Sequence conflict | 226 | 1 | I → T Ref.3 | ||||||
| Sequence conflict | 272 | 1 | I → E Ref.3 | ||||||
| Sequence conflict | 440 | 1 | Missing Ref.3 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. Lucas S.M.Nature 428:529-535(2004) [PubMed: 15057824] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [2] | "N-Shc and Sck, two neuronally expressed Shc adapter homologs. Their differential regional expression in the brain and roles in neurotrophin and Src signaling." Nakamura T., Muraoka S., Sanokawa R., Mori N. J. Biol. Chem. 273:6960-6967(1998) [PubMed: 9507002] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 45-582, INTERACTION WITH THE TRK RECEPTORS, TISSUE SPECIFICITY. |
| [3] | "A family of Shc related proteins with conserved PTB, CH1 and SH2 regions." Pelicci G., Dente L., De Giuseppe A., Verducci-Galletti B., Giuli S., Mele S., Vetriani C., Giorgio M., Pandolfi P.P., Cesareni G., Pelicci P.-G. Oncogene 13:633-641(1996) [PubMed: 8760305] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 96-582. Tissue: Fetal brain. |
| [4] | "An alternative to SH2 domains for binding tyrosine-phosphorylated proteins." Kavanaugh W.M., Williams L.T. Science 266:1862-1865(1994) [PubMed: 7527937] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 114-541. |
| [5] | The European IMAGE consortium Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 191-582. |
| [6] | "ShcB and ShcC activation by the Trk family of receptor tyrosine kinases." Liu H.Y., Meakin S.O. J. Biol. Chem. 277:26046-26056(2002) [PubMed: 12006576] [Abstract] Cited for: PHOSPHORYLATION, INTERACTION WITH THE TRK RECEPTORS. |
| [7] | "Platelet endothelial aggregation receptor 1 (PEAR1), a novel epidermal growth factor repeat-containing transmembrane receptor, participates in platelet contact-induced activation." Nanda N., Bao M., Lin H., Clauser K., Komuves L., Quertermous T., Conley P.B., Phillips D.R., Hart M.J. J. Biol. Chem. 280:24680-24689(2005) [PubMed: 15851471] [Abstract] Cited for: INTERACTION WITH MEGF12. Tissue: Platelet. |
Cross-references
Sequence databases | |
|---|---|
| AC008988 Genomic DNA. No translation available. AC138433 Genomic DNA. No translation available. AC006124 Genomic DNA. No translation available. AB001451 mRNA. Translation: BAA25798.1. AL360254 mRNA. Translation: CAB96175.1. | |
| RefSeq | NP_036567.2. |
| UniGene | Hs.30965 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1MIL based on UniProtKB P29353. |
| ModBase | Search... |
PTM databases | |
| PhosphoSite | P98077. |
Genome annotation databases | |
| Ensembl | ENSG00000129946. Homo sapiens. [Contig view] |
| GeneID | 25759. |
| KEGG | hsa:25759. |
Organism-specific databases | |
| H-InvDB | HIX0027436. |
| HGNC | HGNC:29869. SHC2. |
| HPA | HPA006136. |
| MIM | 605217. gene. |
| PharmGKB | PA134971076. |
| GenAtlas | Search... |
| GeneCards | Search... |
Phylogenomic databases | |
| HOGENOM | P98077. |
| HOVERGEN | P98077. |
Gene expression databases | |
| ArrayExpress | P98077. |
| CleanEx | HS_SHC2. |
| GermOnline | ENSG00000129946. Homo sapiens. |
Family and domain databases | |
| PRINTS | PR00401. SH2DOMAIN. PR00629. SHCPIDOMAIN. |
| ProDom | PD000093. SH2. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| SMART | SM00462. PTB. 1 hit. SM00252. SH2. 1 hit. [Graphical view] |
| PROSITE | PS01179. PID. 1 hit. PS50001. SH2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 46868. |
| SOURCE | Search... |
Entry information
| Entry name | SHC2_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P98077 Secondary accession number(s): O60230, Q9NPL5, Q9UCX4 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 19 Human chromosome 19: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


