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Protein

Enteropeptidase

Gene

TMPRSS15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Responsible for initiating activation of pancreatic proteolytic proenzymes (trypsin, chymotrypsin and carboxypeptidase A). It catalyzes the conversion of trypsinogen to trypsin which in turn activates other proenzymes including chymotrypsinogen, procarboxypeptidases, and proelastases.

Catalytic activityi

Activation of trypsinogen by selective cleavage of 6-Lys-|-Ile-7 bond.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei825Charge relay systemBy similarity1
Active sitei876Charge relay systemBy similarity1
Active sitei971Charge relay systemBy similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Enzyme and pathway databases

BioCyciZFISH:HS07996-MONOMER.
BRENDAi3.4.21.9. 2681.

Protein family/group databases

MEROPSiS01.156.

Names & Taxonomyi

Protein namesi
Recommended name:
Enteropeptidase (EC:3.4.21.9)
Alternative name(s):
Enterokinase
Serine protease 7
Transmembrane protease serine 15
Cleaved into the following 2 chains:
Gene namesi
Name:TMPRSS15
Synonyms:ENTK, PRSS7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

HGNCiHGNC:9490. TMPRSS15.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 18CytoplasmicSequence analysisAdd BLAST17
Transmembranei19 – 47Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST29
Topological domaini48 – 1019ExtracellularSequence analysisAdd BLAST972

GO - Cellular componenti

  • brush border Source: ProtInc
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

Enterokinase deficiency (ENTKD)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionLife-threatening intestinal malabsorption disorder characterized by diarrhea and failure to thrive.
See also OMIM:226200

Organism-specific databases

DisGeNETi5651.
MalaCardsiTMPRSS15.
MIMi226200. phenotype.
OpenTargetsiENSG00000154646.
Orphaneti168601. Congenital enteropathy due to enteropeptidase deficiency.
PharmGKBiPA33839.

Chemistry databases

ChEMBLiCHEMBL1741195.

Polymorphism and mutation databases

BioMutaiTMPRSS15.
DMDMi317373442.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedSequence analysis
ChainiPRO_00000277192 – 784Enteropeptidase non-catalytic heavy chainAdd BLAST783
ChainiPRO_0000027720785 – 1019Enteropeptidase catalytic light chainAdd BLAST235

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineSequence analysis1
Glycosylationi116N-linked (GlcNAc...)Sequence analysis1
Glycosylationi147N-linked (GlcNAc...)Sequence analysis1
Glycosylationi179N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi184 ↔ 197By similarity
Disulfide bondi191 ↔ 210By similarity
Disulfide bondi204 ↔ 221By similarity
Disulfide bondi225 ↔ 253By similarity
Glycosylationi328N-linked (GlcNAc...)Sequence analysis1
Glycosylationi335N-linked (GlcNAc...)Sequence analysis1
Glycosylationi388N-linked (GlcNAc...)Sequence analysis1
Glycosylationi440N-linked (GlcNAc...)Sequence analysis1
Glycosylationi470N-linked (GlcNAc...)Sequence analysis1
Glycosylationi503N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi524 ↔ 552By similarity
Glycosylationi534N-linked (GlcNAc...)Sequence analysis1
Glycosylationi630N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi643 ↔ 655By similarity
Disulfide bondi650 ↔ 668By similarity
Disulfide bondi662 ↔ 677By similarity
Glycosylationi682N-linked (GlcNAc...)Sequence analysis1
Glycosylationi706N-linked (GlcNAc...)Sequence analysis1
Glycosylationi725N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi757 ↔ 767By similarity
Disulfide bondi772 ↔ 896Interchain (between heavy and light chains)PROSITE-ProRule annotation
Disulfide bondi810 ↔ 8261 Publication
Glycosylationi848N-linked (GlcNAc...)Sequence analysis1
Glycosylationi887N-linked (GlcNAc...)Sequence analysis1
Glycosylationi909N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi910 ↔ 9771 Publication
Disulfide bondi941 ↔ 9561 Publication
Glycosylationi949N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi967 ↔ 9951 Publication

Post-translational modificationi

The chains are derived from a single precursor that is cleaved by a trypsin-like protease.

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Myristate, Zymogen

Proteomic databases

PaxDbiP98073.
PeptideAtlasiP98073.
PRIDEiP98073.

PTM databases

iPTMnetiP98073.
PhosphoSitePlusiP98073.

Expressioni

Tissue specificityi

Intestinal brush border.

Gene expression databases

BgeeiENSG00000154646.
CleanExiHS_PRSS7.
ExpressionAtlasiP98073. baseline and differential.
GenevisibleiP98073. HS.

Organism-specific databases

HPAiHPA015611.

Interactioni

Subunit structurei

Heterodimer of a catalytic (light) chain and a multidomain (heavy) chain linked by a disulfide bond.

Protein-protein interaction databases

BioGridi111632. 1 interactor.
IntActiP98073. 3 interactors.
STRINGi9606.ENSP00000284885.

Chemistry databases

BindingDBiP98073.

Structurei

Secondary structure

11019
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi799 – 804Combined sources6
Beta strandi807 – 814Combined sources8
Beta strandi816 – 822Combined sources7
Helixi824 – 827Combined sources4
Helixi834 – 836Combined sources3
Beta strandi837 – 842Combined sources6
Beta strandi855 – 864Combined sources10
Turni870 – 873Combined sources4
Beta strandi878 – 884Combined sources7
Beta strandi909 – 919Combined sources11
Beta strandi929 – 936Combined sources8
Helixi938 – 944Combined sources7
Beta strandi954 – 957Combined sources4
Beta strandi974 – 979Combined sources6
Beta strandi982 – 991Combined sources10
Beta strandi993 – 996Combined sources4
Beta strandi1002 – 1006Combined sources5
Helixi1007 – 1009Combined sources3
Helixi1011 – 1015Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4DGJX-ray1.90A/B/C/D785-1019[»]
ProteinModelPortaliP98073.
SMRiP98073.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini54 – 169SEAPROSITE-ProRule annotationAdd BLAST116
Domaini182 – 223LDL-receptor class A 1PROSITE-ProRule annotationAdd BLAST42
Domaini225 – 334CUB 1PROSITE-ProRule annotationAdd BLAST110
Domaini342 – 504MAMPROSITE-ProRule annotationAdd BLAST163
Domaini524 – 634CUB 2PROSITE-ProRule annotationAdd BLAST111
Domaini641 – 679LDL-receptor class A 2PROSITE-ProRule annotationAdd BLAST39
Domaini678 – 771SRCRPROSITE-ProRule annotationAdd BLAST94
Domaini785 – 1019Peptidase S1PROSITE-ProRule annotationAdd BLAST235

Sequence similaritiesi

Belongs to the peptidase S1 family.PROSITE-ProRule annotation
Contains 2 CUB domains.PROSITE-ProRule annotation
Contains 2 LDL-receptor class A domains.PROSITE-ProRule annotation
Contains 1 MAM domain.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation
Contains 1 SEA domain.PROSITE-ProRule annotation
Contains 1 SRCR domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00760000118962.
HOGENOMiHOG000112380.
HOVERGENiHBG005588.
InParanoidiP98073.
KOiK01316.
OMAiFEDGFCF.
OrthoDBiEOG091G0DF7.
PhylomeDBiP98073.
TreeFamiTF351678.

Family and domain databases

CDDicd00041. CUB. 2 hits.
cd06263. MAM. 1 hit.
cd00190. Tryp_SPc. 1 hit.
Gene3Di2.60.120.290. 2 hits.
3.10.250.10. 1 hit.
3.30.70.960. 1 hit.
4.10.400.10. 2 hits.
InterProiIPR013320. ConA-like_dom.
IPR000859. CUB_dom.
IPR023415. LDLR_class-A_CS.
IPR002172. LDrepeatLR_classA_rpt.
IPR000998. MAM_dom.
IPR011163. Pept_S1A_enterop.
IPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR000082. SEA_dom.
IPR001190. SRCR.
IPR017448. SRCR-like_dom.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF00431. CUB. 2 hits.
PF00057. Ldl_recept_a. 2 hits.
PF00629. MAM. 1 hit.
PF01390. SEA. 1 hit.
PF15494. SRCR_2. 1 hit.
PF00089. Trypsin. 1 hit.
[Graphical view]
PIRSFiPIRSF001138. Enteropeptidase. 1 hit.
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00042. CUB. 2 hits.
SM00192. LDLa. 2 hits.
SM00137. MAM. 1 hit.
SM00200. SEA. 1 hit.
SM00202. SR. 1 hit.
SM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF49854. SSF49854. 2 hits.
SSF49899. SSF49899. 1 hit.
SSF50494. SSF50494. 1 hit.
SSF56487. SSF56487. 1 hit.
SSF57424. SSF57424. 2 hits.
SSF82671. SSF82671. 1 hit.
PROSITEiPS01180. CUB. 2 hits.
PS01209. LDLRA_1. 2 hits.
PS50068. LDLRA_2. 2 hits.
PS00740. MAM_1. 1 hit.
PS50060. MAM_2. 1 hit.
PS50024. SEA. 1 hit.
PS50287. SRCR_2. 1 hit.
PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P98073-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSKRGISSR HHSLSSYEIM FAALFAILVV LCAGLIAVSC LTIKESQRGA
60 70 80 90 100
ALGQSHEARA TFKITSGVTY NPNLQDKLSV DFKVLAFDLQ QMIDEIFLSS
110 120 130 140 150
NLKNEYKNSR VLQFENGSII VVFDLFFAQW VSDENVKEEL IQGLEANKSS
160 170 180 190 200
QLVTFHIDLN SVDILDKLTT TSHLATPGNV SIECLPGSSP CTDALTCIKA
210 220 230 240 250
DLFCDGEVNC PDGSDEDNKM CATVCDGRFL LTGSSGSFQA THYPKPSETS
260 270 280 290 300
VVCQWIIRVN QGLSIKLSFD DFNTYYTDIL DIYEGVGSSK ILRASIWETN
310 320 330 340 350
PGTIRIFSNQ VTATFLIESD ESDYVGFNAT YTAFNSSELN NYEKINCNFE
360 370 380 390 400
DGFCFWVQDL NDDNEWERIQ GSTFSPFTGP NFDHTFGNAS GFYISTPTGP
410 420 430 440 450
GGRQERVGLL SLPLDPTLEP ACLSFWYHMY GENVHKLSIN ISNDQNMEKT
460 470 480 490 500
VFQKEGNYGD NWNYGQVTLN ETVKFKVAFN AFKNKILSDI ALDDISLTYG
510 520 530 540 550
ICNGSLYPEP TLVPTPPPEL PTDCGGPFEL WEPNTTFSST NFPNSYPNLA
560 570 580 590 600
FCVWILNAQK GKNIQLHFQE FDLENINDVV EIRDGEEADS LLLAVYTGPG
610 620 630 640 650
PVKDVFSTTN RMTVLLITND VLARGGFKAN FTTGYHLGIP EPCKADHFQC
660 670 680 690 700
KNGECVPLVN LCDGHLHCED GSDEADCVRF FNGTTNNNGL VRFRIQSIWH
710 720 730 740 750
TACAENWTTQ ISNDVCQLLG LGSGNSSKPI FPTDGGPFVK LNTAPDGHLI
760 770 780 790 800
LTPSQQCLQD SLIRLQCNHK SCGKKLAAQD ITPKIVGGSN AKEGAWPWVV
810 820 830 840 850
GLYYGGRLLC GASLVSSDWL VSAAHCVYGR NLEPSKWTAI LGLHMKSNLT
860 870 880 890 900
SPQTVPRLID EIVINPHYNR RRKDNDIAMM HLEFKVNYTD YIQPICLPEE
910 920 930 940 950
NQVFPPGRNC SIAGWGTVVY QGTTANILQE ADVPLLSNER CQQQMPEYNI
960 970 980 990 1000
TENMICAGYE EGGIDSCQGD SGGPLMCQEN NRWFLAGVTS FGYKCALPNR
1010
PGVYARVSRF TEWIQSFLH
Length:1,019
Mass (Da):112,935
Last modified:January 11, 2011 - v3
Checksum:i45288F0636E5EC52
GO

Sequence cautioni

The sequence CAB90389 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03168665T → I.Corresponds to variant rs35987974dbSNPEnsembl.1
Natural variantiVAR_02194077K → R.Corresponds to variant rs2824804dbSNPEnsembl.1
Natural variantiVAR_031687134E → Q.3 PublicationsCorresponds to variant rs2824790dbSNPEnsembl.1
Natural variantiVAR_031688545S → C.Corresponds to variant rs8134187dbSNPEnsembl.1
Natural variantiVAR_020175641E → K.Corresponds to variant rs2273204dbSNPEnsembl.1
Natural variantiVAR_024292660N → H.Corresponds to variant rs11088674dbSNPEnsembl.1
Natural variantiVAR_031689732P → S.3 PublicationsCorresponds to variant rs2824721dbSNPEnsembl.1
Natural variantiVAR_031690828Y → C.Corresponds to variant rs8130110dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09860 mRNA. Translation: AAC50138.1.
Y19124
, Y19125, Y19126, Y19127, Y19128, Y19129, Y19130, Y19131, Y19132, Y19133, Y19134, Y19135, Y19136, Y19137, Y19138, Y19139, Y19140, Y19141, Y19142, Y19143 Genomic DNA. Translation: CAB65555.1.
AL163217 Genomic DNA. Translation: CAB90389.1. Sequence problems.
AL163218 Genomic DNA. Translation: CAB90392.1.
BC111749 mRNA. Translation: AAI11750.1.
CCDSiCCDS13571.1.
PIRiA56318.
RefSeqiNP_002763.2. NM_002772.2.
UniGeneiHs.149473.

Genome annotation databases

EnsembliENST00000284885; ENSP00000284885; ENSG00000154646.
GeneIDi5651.
KEGGihsa:5651.
UCSCiuc002ykw.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09860 mRNA. Translation: AAC50138.1.
Y19124
, Y19125, Y19126, Y19127, Y19128, Y19129, Y19130, Y19131, Y19132, Y19133, Y19134, Y19135, Y19136, Y19137, Y19138, Y19139, Y19140, Y19141, Y19142, Y19143 Genomic DNA. Translation: CAB65555.1.
AL163217 Genomic DNA. Translation: CAB90389.1. Sequence problems.
AL163218 Genomic DNA. Translation: CAB90392.1.
BC111749 mRNA. Translation: AAI11750.1.
CCDSiCCDS13571.1.
PIRiA56318.
RefSeqiNP_002763.2. NM_002772.2.
UniGeneiHs.149473.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4DGJX-ray1.90A/B/C/D785-1019[»]
ProteinModelPortaliP98073.
SMRiP98073.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111632. 1 interactor.
IntActiP98073. 3 interactors.
STRINGi9606.ENSP00000284885.

Chemistry databases

BindingDBiP98073.
ChEMBLiCHEMBL1741195.

Protein family/group databases

MEROPSiS01.156.

PTM databases

iPTMnetiP98073.
PhosphoSitePlusiP98073.

Polymorphism and mutation databases

BioMutaiTMPRSS15.
DMDMi317373442.

Proteomic databases

PaxDbiP98073.
PeptideAtlasiP98073.
PRIDEiP98073.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000284885; ENSP00000284885; ENSG00000154646.
GeneIDi5651.
KEGGihsa:5651.
UCSCiuc002ykw.4. human.

Organism-specific databases

CTDi5651.
DisGeNETi5651.
GeneCardsiTMPRSS15.
HGNCiHGNC:9490. TMPRSS15.
HPAiHPA015611.
MalaCardsiTMPRSS15.
MIMi226200. phenotype.
606635. gene.
neXtProtiNX_P98073.
OpenTargetsiENSG00000154646.
Orphaneti168601. Congenital enteropathy due to enteropeptidase deficiency.
PharmGKBiPA33839.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00760000118962.
HOGENOMiHOG000112380.
HOVERGENiHBG005588.
InParanoidiP98073.
KOiK01316.
OMAiFEDGFCF.
OrthoDBiEOG091G0DF7.
PhylomeDBiP98073.
TreeFamiTF351678.

Enzyme and pathway databases

BioCyciZFISH:HS07996-MONOMER.
BRENDAi3.4.21.9. 2681.

Miscellaneous databases

GenomeRNAii5651.
PROiP98073.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000154646.
CleanExiHS_PRSS7.
ExpressionAtlasiP98073. baseline and differential.
GenevisibleiP98073. HS.

Family and domain databases

CDDicd00041. CUB. 2 hits.
cd06263. MAM. 1 hit.
cd00190. Tryp_SPc. 1 hit.
Gene3Di2.60.120.290. 2 hits.
3.10.250.10. 1 hit.
3.30.70.960. 1 hit.
4.10.400.10. 2 hits.
InterProiIPR013320. ConA-like_dom.
IPR000859. CUB_dom.
IPR023415. LDLR_class-A_CS.
IPR002172. LDrepeatLR_classA_rpt.
IPR000998. MAM_dom.
IPR011163. Pept_S1A_enterop.
IPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR000082. SEA_dom.
IPR001190. SRCR.
IPR017448. SRCR-like_dom.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF00431. CUB. 2 hits.
PF00057. Ldl_recept_a. 2 hits.
PF00629. MAM. 1 hit.
PF01390. SEA. 1 hit.
PF15494. SRCR_2. 1 hit.
PF00089. Trypsin. 1 hit.
[Graphical view]
PIRSFiPIRSF001138. Enteropeptidase. 1 hit.
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00042. CUB. 2 hits.
SM00192. LDLa. 2 hits.
SM00137. MAM. 1 hit.
SM00200. SEA. 1 hit.
SM00202. SR. 1 hit.
SM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF49854. SSF49854. 2 hits.
SSF49899. SSF49899. 1 hit.
SSF50494. SSF50494. 1 hit.
SSF56487. SSF56487. 1 hit.
SSF57424. SSF57424. 2 hits.
SSF82671. SSF82671. 1 hit.
PROSITEiPS01180. CUB. 2 hits.
PS01209. LDLRA_1. 2 hits.
PS50068. LDLRA_2. 2 hits.
PS00740. MAM_1. 1 hit.
PS50060. MAM_2. 1 hit.
PS50024. SEA. 1 hit.
PS50287. SRCR_2. 1 hit.
PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiENTK_HUMAN
AccessioniPrimary (citable) accession number: P98073
Secondary accession number(s): Q2NKL7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: January 11, 2011
Last modified: November 30, 2016
This is version 178 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Peptidase families
    Classification of peptidase families and list of entries
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.