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P98073

- ENTK_HUMAN

UniProt

P98073 - ENTK_HUMAN

Protein

Enteropeptidase

Gene

TMPRSS15

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 157 (01 Oct 2014)
      Sequence version 3 (11 Jan 2011)
      Previous versions | rss
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    Functioni

    Responsible for initiating activation of pancreatic proteolytic proenzymes (trypsin, chymotrypsin and carboxypeptidase A). It catalyzes the conversion of trypsinogen to trypsin which in turn activates other proenzymes including chymotrypsinogen, procarboxypeptidases, and proelastases.

    Catalytic activityi

    Activation of trypsinogen by selective cleavage of 6-Lys-|-Ile-7 bond.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei825 – 8251Charge relay systemBy similarity
    Active sitei876 – 8761Charge relay systemBy similarity
    Active sitei971 – 9711Charge relay systemBy similarity

    GO - Molecular functioni

    1. scavenger receptor activity Source: InterPro
    2. serine-type endopeptidase activity Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Serine protease

    Enzyme and pathway databases

    BRENDAi3.4.21.9. 2681.

    Protein family/group databases

    MEROPSiS01.156.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Enteropeptidase (EC:3.4.21.9)
    Alternative name(s):
    Enterokinase
    Serine protease 7
    Transmembrane protease serine 15
    Cleaved into the following 2 chains:
    Gene namesi
    Name:TMPRSS15
    Synonyms:ENTK, PRSS7
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 21

    Organism-specific databases

    HGNCiHGNC:9490. TMPRSS15.

    Subcellular locationi

    GO - Cellular componenti

    1. brush border Source: ProtInc
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Enterokinase deficiency (ENTKD) [MIM:226200]: Life-threatening intestinal malabsorption disorder characterized by diarrhea and failure to thrive.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.

    Organism-specific databases

    MIMi226200. phenotype.
    Orphaneti168601. Congenital enteropathy due to enteropeptidase deficiency.
    PharmGKBiPA33839.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedSequence Analysis
    Chaini2 – 784783Enteropeptidase non-catalytic heavy chainPRO_0000027719Add
    BLAST
    Chaini785 – 1019235Enteropeptidase catalytic light chainPRO_0000027720Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi2 – 21N-myristoyl glycineSequence Analysis
    Glycosylationi116 – 1161N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi147 – 1471N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi179 – 1791N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi184 ↔ 197By similarity
    Disulfide bondi191 ↔ 210By similarity
    Disulfide bondi204 ↔ 221By similarity
    Disulfide bondi225 ↔ 253By similarity
    Glycosylationi328 – 3281N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi335 – 3351N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi388 – 3881N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi440 – 4401N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi470 – 4701N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi503 – 5031N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi524 ↔ 552By similarity
    Glycosylationi534 – 5341N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi630 – 6301N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi643 ↔ 655By similarity
    Disulfide bondi650 ↔ 668By similarity
    Disulfide bondi662 ↔ 677By similarity
    Glycosylationi682 – 6821N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi706 – 7061N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi725 – 7251N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi757 ↔ 767By similarity
    Disulfide bondi772 ↔ 896Interchain (between heavy and light chains)PROSITE-ProRule annotation
    Disulfide bondi810 ↔ 8261 Publication
    Glycosylationi848 – 8481N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi887 – 8871N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi909 – 9091N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi910 ↔ 9771 Publication
    Disulfide bondi941 ↔ 9561 Publication
    Glycosylationi949 – 9491N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi967 ↔ 9951 Publication

    Post-translational modificationi

    The chains are derived from a single precursor that is cleaved by a trypsin-like protease.

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Myristate, Zymogen

    Proteomic databases

    PaxDbiP98073.
    PRIDEiP98073.

    PTM databases

    PhosphoSiteiP98073.

    Expressioni

    Tissue specificityi

    Intestinal brush border.

    Gene expression databases

    ArrayExpressiP98073.
    BgeeiP98073.
    CleanExiHS_PRSS7.
    GenevestigatoriP98073.

    Organism-specific databases

    HPAiHPA015611.

    Interactioni

    Subunit structurei

    Heterodimer of a catalytic (light) chain and a multidomain (heavy) chain linked by a disulfide bond.

    Protein-protein interaction databases

    IntActiP98073. 2 interactions.

    Structurei

    Secondary structure

    1
    1019
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi799 – 8046
    Beta strandi807 – 8148
    Beta strandi816 – 8227
    Helixi824 – 8274
    Helixi834 – 8363
    Beta strandi837 – 8426
    Beta strandi855 – 86410
    Turni870 – 8734
    Beta strandi878 – 8847
    Beta strandi909 – 91911
    Beta strandi929 – 9368
    Helixi938 – 9447
    Beta strandi954 – 9574
    Beta strandi974 – 9796
    Beta strandi982 – 99110
    Beta strandi993 – 9964
    Beta strandi1002 – 10065
    Helixi1007 – 10093
    Helixi1011 – 10155

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4DGJX-ray1.90A/B/C/D785-1019[»]
    ProteinModelPortaliP98073.
    SMRiP98073. Positions 271-510, 523-658, 748-1019.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini2 – 1817CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini48 – 1019972ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei19 – 4729Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini54 – 169116SEAPROSITE-ProRule annotationAdd
    BLAST
    Domaini182 – 22342LDL-receptor class A 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini225 – 334110CUB 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini342 – 504163MAMPROSITE-ProRule annotationAdd
    BLAST
    Domaini524 – 634111CUB 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini641 – 67939LDL-receptor class A 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini678 – 77194SRCRPROSITE-ProRule annotationAdd
    BLAST
    Domaini785 – 1019235Peptidase S1PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase S1 family.PROSITE-ProRule annotation
    Contains 2 CUB domains.PROSITE-ProRule annotation
    Contains 2 LDL-receptor class A domains.PROSITE-ProRule annotation
    Contains 1 MAM domain.PROSITE-ProRule annotation
    Contains 1 peptidase S1 domain.PROSITE-ProRule annotation
    Contains 1 SEA domain.PROSITE-ProRule annotation
    Contains 1 SRCR domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG5640.
    HOGENOMiHOG000112380.
    HOVERGENiHBG005588.
    InParanoidiP98073.
    KOiK01316.
    OMAiFEDGFCF.
    OrthoDBiEOG7RNK07.
    PhylomeDBiP98073.
    TreeFamiTF351678.

    Family and domain databases

    Gene3Di2.60.120.290. 2 hits.
    3.10.250.10. 1 hit.
    3.30.70.960. 1 hit.
    4.10.400.10. 2 hits.
    InterProiIPR008985. ConA-like_lec_gl_sf.
    IPR000859. CUB_dom.
    IPR023415. LDLR_class-A_CS.
    IPR002172. LDrepeatLR_classA_rpt.
    IPR000998. MAM_dom.
    IPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR000082. SEA_dom.
    IPR001190. SRCR.
    IPR017448. SRCR-like_dom.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view]
    PfamiPF00431. CUB. 2 hits.
    PF00057. Ldl_recept_a. 1 hit.
    PF00629. MAM. 1 hit.
    PF01390. SEA. 1 hit.
    PF00089. Trypsin. 1 hit.
    [Graphical view]
    PRINTSiPR00722. CHYMOTRYPSIN.
    SMARTiSM00042. CUB. 2 hits.
    SM00192. LDLa. 2 hits.
    SM00137. MAM. 1 hit.
    SM00200. SEA. 1 hit.
    SM00202. SR. 1 hit.
    SM00020. Tryp_SPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF49854. SSF49854. 2 hits.
    SSF49899. SSF49899. 1 hit.
    SSF50494. SSF50494. 1 hit.
    SSF56487. SSF56487. 1 hit.
    SSF57424. SSF57424. 2 hits.
    SSF82671. SSF82671. 1 hit.
    PROSITEiPS01180. CUB. 2 hits.
    PS01209. LDLRA_1. 2 hits.
    PS50068. LDLRA_2. 2 hits.
    PS00740. MAM_1. 1 hit.
    PS50060. MAM_2. 1 hit.
    PS50024. SEA. 1 hit.
    PS50287. SRCR_2. 1 hit.
    PS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P98073-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGSKRGISSR HHSLSSYEIM FAALFAILVV LCAGLIAVSC LTIKESQRGA     50
    ALGQSHEARA TFKITSGVTY NPNLQDKLSV DFKVLAFDLQ QMIDEIFLSS 100
    NLKNEYKNSR VLQFENGSII VVFDLFFAQW VSDENVKEEL IQGLEANKSS 150
    QLVTFHIDLN SVDILDKLTT TSHLATPGNV SIECLPGSSP CTDALTCIKA 200
    DLFCDGEVNC PDGSDEDNKM CATVCDGRFL LTGSSGSFQA THYPKPSETS 250
    VVCQWIIRVN QGLSIKLSFD DFNTYYTDIL DIYEGVGSSK ILRASIWETN 300
    PGTIRIFSNQ VTATFLIESD ESDYVGFNAT YTAFNSSELN NYEKINCNFE 350
    DGFCFWVQDL NDDNEWERIQ GSTFSPFTGP NFDHTFGNAS GFYISTPTGP 400
    GGRQERVGLL SLPLDPTLEP ACLSFWYHMY GENVHKLSIN ISNDQNMEKT 450
    VFQKEGNYGD NWNYGQVTLN ETVKFKVAFN AFKNKILSDI ALDDISLTYG 500
    ICNGSLYPEP TLVPTPPPEL PTDCGGPFEL WEPNTTFSST NFPNSYPNLA 550
    FCVWILNAQK GKNIQLHFQE FDLENINDVV EIRDGEEADS LLLAVYTGPG 600
    PVKDVFSTTN RMTVLLITND VLARGGFKAN FTTGYHLGIP EPCKADHFQC 650
    KNGECVPLVN LCDGHLHCED GSDEADCVRF FNGTTNNNGL VRFRIQSIWH 700
    TACAENWTTQ ISNDVCQLLG LGSGNSSKPI FPTDGGPFVK LNTAPDGHLI 750
    LTPSQQCLQD SLIRLQCNHK SCGKKLAAQD ITPKIVGGSN AKEGAWPWVV 800
    GLYYGGRLLC GASLVSSDWL VSAAHCVYGR NLEPSKWTAI LGLHMKSNLT 850
    SPQTVPRLID EIVINPHYNR RRKDNDIAMM HLEFKVNYTD YIQPICLPEE 900
    NQVFPPGRNC SIAGWGTVVY QGTTANILQE ADVPLLSNER CQQQMPEYNI 950
    TENMICAGYE EGGIDSCQGD SGGPLMCQEN NRWFLAGVTS FGYKCALPNR 1000
    PGVYARVSRF TEWIQSFLH 1019
    Length:1,019
    Mass (Da):112,935
    Last modified:January 11, 2011 - v3
    Checksum:i45288F0636E5EC52
    GO

    Sequence cautioni

    The sequence CAB90389.1 differs from that shown. Reason: Erroneous gene model prediction.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti65 – 651T → I.
    Corresponds to variant rs35987974 [ dbSNP | Ensembl ].
    VAR_031686
    Natural varianti77 – 771K → R.
    Corresponds to variant rs2824804 [ dbSNP | Ensembl ].
    VAR_021940
    Natural varianti134 – 1341E → Q.3 Publications
    Corresponds to variant rs2824790 [ dbSNP | Ensembl ].
    VAR_031687
    Natural varianti545 – 5451S → C.
    Corresponds to variant rs8134187 [ dbSNP | Ensembl ].
    VAR_031688
    Natural varianti641 – 6411E → K.
    Corresponds to variant rs2273204 [ dbSNP | Ensembl ].
    VAR_020175
    Natural varianti660 – 6601N → H.
    Corresponds to variant rs11088674 [ dbSNP | Ensembl ].
    VAR_024292
    Natural varianti732 – 7321P → S.3 Publications
    Corresponds to variant rs2824721 [ dbSNP | Ensembl ].
    VAR_031689
    Natural varianti828 – 8281Y → C.
    Corresponds to variant rs8130110 [ dbSNP | Ensembl ].
    VAR_031690

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U09860 mRNA. Translation: AAC50138.1.
    Y19124
    , Y19125, Y19126, Y19127, Y19128, Y19129, Y19130, Y19131, Y19132, Y19133, Y19134, Y19135, Y19136, Y19137, Y19138, Y19139, Y19140, Y19141, Y19142, Y19143 Genomic DNA. Translation: CAB65555.1.
    AL163217 Genomic DNA. Translation: CAB90389.1. Sequence problems.
    AL163218 Genomic DNA. Translation: CAB90392.1.
    BC111749 mRNA. Translation: AAI11750.1.
    CCDSiCCDS13571.1.
    PIRiA56318.
    RefSeqiNP_002763.2. NM_002772.2.
    UniGeneiHs.149473.

    Genome annotation databases

    EnsembliENST00000284885; ENSP00000284885; ENSG00000154646.
    GeneIDi5651.
    KEGGihsa:5651.
    UCSCiuc002ykw.3. human.

    Polymorphism databases

    DMDMi317373442.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U09860 mRNA. Translation: AAC50138.1 .
    Y19124
    , Y19125 , Y19126 , Y19127 , Y19128 , Y19129 , Y19130 , Y19131 , Y19132 , Y19133 , Y19134 , Y19135 , Y19136 , Y19137 , Y19138 , Y19139 , Y19140 , Y19141 , Y19142 , Y19143 Genomic DNA. Translation: CAB65555.1 .
    AL163217 Genomic DNA. Translation: CAB90389.1 . Sequence problems.
    AL163218 Genomic DNA. Translation: CAB90392.1 .
    BC111749 mRNA. Translation: AAI11750.1 .
    CCDSi CCDS13571.1.
    PIRi A56318.
    RefSeqi NP_002763.2. NM_002772.2.
    UniGenei Hs.149473.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4DGJ X-ray 1.90 A/B/C/D 785-1019 [» ]
    ProteinModelPortali P98073.
    SMRi P98073. Positions 271-510, 523-658, 748-1019.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P98073. 2 interactions.

    Chemistry

    ChEMBLi CHEMBL1741195.

    Protein family/group databases

    MEROPSi S01.156.

    PTM databases

    PhosphoSitei P98073.

    Polymorphism databases

    DMDMi 317373442.

    Proteomic databases

    PaxDbi P98073.
    PRIDEi P98073.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000284885 ; ENSP00000284885 ; ENSG00000154646 .
    GeneIDi 5651.
    KEGGi hsa:5651.
    UCSCi uc002ykw.3. human.

    Organism-specific databases

    CTDi 5651.
    GeneCardsi GC21M019641.
    HGNCi HGNC:9490. TMPRSS15.
    HPAi HPA015611.
    MIMi 226200. phenotype.
    606635. gene.
    neXtProti NX_P98073.
    Orphaneti 168601. Congenital enteropathy due to enteropeptidase deficiency.
    PharmGKBi PA33839.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5640.
    HOGENOMi HOG000112380.
    HOVERGENi HBG005588.
    InParanoidi P98073.
    KOi K01316.
    OMAi FEDGFCF.
    OrthoDBi EOG7RNK07.
    PhylomeDBi P98073.
    TreeFami TF351678.

    Enzyme and pathway databases

    BRENDAi 3.4.21.9. 2681.

    Miscellaneous databases

    GenomeRNAii 5651.
    NextBioi 21958.
    PROi P98073.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P98073.
    Bgeei P98073.
    CleanExi HS_PRSS7.
    Genevestigatori P98073.

    Family and domain databases

    Gene3Di 2.60.120.290. 2 hits.
    3.10.250.10. 1 hit.
    3.30.70.960. 1 hit.
    4.10.400.10. 2 hits.
    InterProi IPR008985. ConA-like_lec_gl_sf.
    IPR000859. CUB_dom.
    IPR023415. LDLR_class-A_CS.
    IPR002172. LDrepeatLR_classA_rpt.
    IPR000998. MAM_dom.
    IPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR000082. SEA_dom.
    IPR001190. SRCR.
    IPR017448. SRCR-like_dom.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view ]
    Pfami PF00431. CUB. 2 hits.
    PF00057. Ldl_recept_a. 1 hit.
    PF00629. MAM. 1 hit.
    PF01390. SEA. 1 hit.
    PF00089. Trypsin. 1 hit.
    [Graphical view ]
    PRINTSi PR00722. CHYMOTRYPSIN.
    SMARTi SM00042. CUB. 2 hits.
    SM00192. LDLa. 2 hits.
    SM00137. MAM. 1 hit.
    SM00200. SEA. 1 hit.
    SM00202. SR. 1 hit.
    SM00020. Tryp_SPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49854. SSF49854. 2 hits.
    SSF49899. SSF49899. 1 hit.
    SSF50494. SSF50494. 1 hit.
    SSF56487. SSF56487. 1 hit.
    SSF57424. SSF57424. 2 hits.
    SSF82671. SSF82671. 1 hit.
    PROSITEi PS01180. CUB. 2 hits.
    PS01209. LDLRA_1. 2 hits.
    PS50068. LDLRA_2. 2 hits.
    PS00740. MAM_1. 1 hit.
    PS50060. MAM_2. 1 hit.
    PS50024. SEA. 1 hit.
    PS50287. SRCR_2. 1 hit.
    PS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "cDNA sequence and chromosomal localization of human enterokinase, the proteolytic activator of trypsinogen."
      Kitamoto Y., Veile R.A., Donis-Keller H., Sadler J.E.
      Biochemistry 34:4562-4568(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS GLN-134 AND SER-732.
      Tissue: Duodenum.
    2. "Mutations in the proenteropeptidase gene are the molecular cause of congenital enteropeptidase deficiency."
      Holzinger A., Maier E.M., Buck C., Mayerhofer P.U., Kappler M., Haworth J.C., Moroz S.P., Hadorn H.-B., Sadler J.E., Roscher A.A.
      Am. J. Hum. Genet. 70:20-25(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS GLN-134 AND SER-732, INVOLVEMENT IN ENTKD.
    3. "The DNA sequence of human chromosome 21."
      Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A.
      , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.
      Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS GLN-134 AND SER-732.
    5. "Enterokinase, the initiator of intestinal digestion, is a mosaic protease composed of a distinctive assortment of domains."
      Kitamoto Y., Yuan X., Wu Q., McCourt D.W., Sadler J.E.
      Proc. Natl. Acad. Sci. U.S.A. 91:7588-7592(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 749-1019.
      Tissue: Duodenum.
    6. "Crystal structure of a supercharged variant of the human enteropeptidase light chain."
      Simeonov P., Zahn M., Strater N., Zuchner T.
      Proteins 80:1907-1910(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 785-1019, DISULFIDE BONDS.

    Entry informationi

    Entry nameiENTK_HUMAN
    AccessioniPrimary (citable) accession number: P98073
    Secondary accession number(s): Q2NKL7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: January 11, 2011
    Last modified: October 1, 2014
    This is version 157 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 21
      Human chromosome 21: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. Peptidase families
      Classification of peptidase families and list of entries
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3