##gff-version 3 P98066 UniProtKB Signal peptide 1 17 . . . Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7516184;Dbxref=PMID:7516184 P98066 UniProtKB Chain 18 277 . . . ID=PRO_0000026692;Note=Tumor necrosis factor-inducible gene 6 protein P98066 UniProtKB Domain 36 129 . . . Note=Link;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00323 P98066 UniProtKB Domain 135 247 . . . Note=CUB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00059 P98066 UniProtKB Binding site 183 183 . . . Ontology_term=ECO:0000269,ECO:0007744;evidence=ECO:0000269|PubMed:26468290,ECO:0007744|PDB:2WNO;Dbxref=PMID:26468290 P98066 UniProtKB Binding site 191 191 . . . Ontology_term=ECO:0000269,ECO:0007744;evidence=ECO:0000269|PubMed:26468290,ECO:0007744|PDB:2WNO;Dbxref=PMID:26468290 P98066 UniProtKB Binding site 232 232 . . . Ontology_term=ECO:0000269,ECO:0007744;evidence=ECO:0000269|PubMed:26468290,ECO:0007744|PDB:2WNO;Dbxref=PMID:26468290 P98066 UniProtKB Binding site 234 234 . . . Ontology_term=ECO:0000269,ECO:0007744;evidence=ECO:0000269|PubMed:26468290,ECO:0007744|PDB:2WNO;Dbxref=PMID:26468290 P98066 UniProtKB Binding site 235 235 . . . Ontology_term=ECO:0000269,ECO:0007744;evidence=ECO:0000269|PubMed:26468290,ECO:0007744|PDB:2WNO;Dbxref=PMID:26468290 P98066 UniProtKB Glycosylation 118 118 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 P98066 UniProtKB Glycosylation 258 258 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 P98066 UniProtKB Disulfide bond 58 127 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00323 P98066 UniProtKB Disulfide bond 82 103 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00323 P98066 UniProtKB Disulfide bond 135 161 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00059 P98066 UniProtKB Disulfide bond 188 210 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00059 P98066 UniProtKB Natural variant 144 144 . . . ID=VAR_013005;Note=Q->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:1730767;Dbxref=dbSNP:rs1046668,PMID:15489334,PMID:1730767 P98066 UniProtKB Mutagenesis 39 39 . . . Note=Decreases binding of hyaluronan to CD44. Decreases hyaluronan-dependent lymphocyte rolling. H->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15060082;Dbxref=PMID:15060082 P98066 UniProtKB Mutagenesis 41 41 . . . Note=Has no significant effect on hyaluronan binding to CD44 or hyaluronan-dependent lymphocyte rolling. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15060082;Dbxref=PMID:15060082 P98066 UniProtKB Mutagenesis 46 46 . . . Note=Abolishes binding to bikunin. K->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15917224;Dbxref=PMID:15917224 P98066 UniProtKB Mutagenesis 47 47 . . . Note=Abolishes binding to bikunin. Impairs binding to hyaluronan. Retains the ability to bind heavy chains but cannot transfer them onto hyaluronan. Impairs binding of hyaluronan to CD44. Decreases hyaluronan-dependent lymphocyte rolling. Y->F;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15060082,ECO:0000269|PubMed:15917224,ECO:0000269|PubMed:26468290;Dbxref=PMID:15060082,PMID:15917224,PMID:26468290 P98066 UniProtKB Mutagenesis 48 48 . . . Note=Decreases binding of hyaluronan to CD44. Decreases hyaluronan-dependent lymphocyte rolling. K->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15060082;Dbxref=PMID:15060082 P98066 UniProtKB Mutagenesis 55 55 . . . Note=Decreases binding to heparin. Has normal binding to bikunin. Impairs binding to heparin%3B when associated with A-69 and A-76. Has no effect on CXCL8-induced neutrophil transmigration%3B when associated with A-69 and A-76. K->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15917224,ECO:0000269|PubMed:24501198;Dbxref=PMID:15917224,PMID:24501198 P98066 UniProtKB Mutagenesis 64 64 . . . Note=Increases binding of hyaluronan to CD44. Has no significant effect on hyaluronan-dependent lymphocyte rolling. H->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15060082;Dbxref=PMID:15060082 P98066 UniProtKB Mutagenesis 69 69 . . . Note=Decreases binding to heparin. Has normal binding to bikunin. Impairs binding to heparin%3B when associated with A-55 and A-76. Has no effect on CXCL8-induced neutrophil transmigration%3B when associated with A-55 and A-76. K->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15917224,ECO:0000269|PubMed:24501198;Dbxref=PMID:15917224,PMID:24501198 P98066 UniProtKB Mutagenesis 76 76 . . . Note=Decreases binding to heparin. Has normal binding to bikunin. Impairs binding to heparin and decreases the potentiation effect toward bikunin antiprotease activity%3B when associated with A-55 and A-69. Has no effect on CXCL8-induced neutrophil transmigration%3B when associated with A-55 and A-69. K->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15917224,ECO:0000269|PubMed:24501198;Dbxref=PMID:15917224,PMID:24501198 P98066 UniProtKB Mutagenesis 89 89 . . . Note=Decreases binding to heparin. Has normal binding to bikunin. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15917224;Dbxref=PMID:15917224 P98066 UniProtKB Mutagenesis 94 94 . . . Note=Abolishes binding to bikunin. Has no effect on transesterification reaction. Y->F;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15917224,ECO:0000269|PubMed:26468290;Dbxref=PMID:15917224,PMID:26468290 P98066 UniProtKB Mutagenesis 105 105 . . . Note=Impairs binding of hyaluronan to CD44. Decreases hyaluronan-dependent lymphocyte rolling. F->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15060082;Dbxref=PMID:15060082 P98066 UniProtKB Mutagenesis 113 113 . . . Note=Abolishes binding to bikunin. Impairs binding of hyaluronan to CD44. Decreases hyaluronan-dependent lymphocyte rolling. Has no effect on transesterification reaction. Y->F;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15060082,ECO:0000269|PubMed:15917224,ECO:0000269|PubMed:26468290;Dbxref=PMID:15060082,PMID:15917224,PMID:26468290 P98066 UniProtKB Mutagenesis 183 183 . . . Note=Reduces the binding affinity to calcium ions. Abolishes the interaction with heavy chain ITIH1. E->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26468290;Dbxref=PMID:26468290 P98066 UniProtKB Beta strand 37 40 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2PF5 P98066 UniProtKB Beta strand 42 44 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1O7B P98066 UniProtKB Beta strand 45 47 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2PF5 P98066 UniProtKB Helix 51 60 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2PF5 P98066 UniProtKB Helix 68 76 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2PF5 P98066 UniProtKB Beta strand 85 87 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1O7B P98066 UniProtKB Helix 88 90 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2PF5 P98066 UniProtKB Beta strand 91 97 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2PF5 P98066 UniProtKB Turn 101 103 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1O7B P98066 UniProtKB Beta strand 109 115 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2PF5 P98066 UniProtKB Beta strand 123 128 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2PF5 P98066 UniProtKB Beta strand 137 139 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2WNO P98066 UniProtKB Beta strand 141 147 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2WNO P98066 UniProtKB Turn 149 152 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2WNO P98066 UniProtKB Beta strand 160 166 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2WNO P98066 UniProtKB Beta strand 172 181 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2WNO P98066 UniProtKB Beta strand 190 209 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2WNO P98066 UniProtKB Beta strand 211 213 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2WNO P98066 UniProtKB Beta strand 221 230 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2WNO P98066 UniProtKB Beta strand 239 247 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2WNO