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Protein

Tumor necrosis factor-inducible gene 6 protein

Gene

TNFAIP6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Possibly involved in cell-cell and cell-matrix interactions during inflammation and tumorigenesis.

GO - Molecular functioni

  • hyaluronic acid binding Source: ProtInc

GO - Biological processi

  • cell adhesion Source: UniProtKB-KW
  • cell-cell signaling Source: ProtInc
  • inflammatory response Source: ProtInc
  • negative regulation of inflammatory response Source: CACAO
  • ovulation Source: Ensembl
  • positive regulation of cell migration Source: Ensembl
  • signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Enzyme and pathway databases

BioCyciZFISH:ENSG00000123610-MONOMER.
ReactomeiR-HSA-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor-inducible gene 6 protein
Alternative name(s):
Hyaluronate-binding protein
TNF-stimulated gene 6 protein
Short name:
TSG-6
Tumor necrosis factor alpha-induced protein 6
Short name:
TNF alpha-induced protein 6
Gene namesi
Name:TNFAIP6
Synonyms:TSG6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:11898. TNFAIP6.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi7130.
OpenTargetsiENSG00000123610.
PharmGKBiPA36595.

Chemistry databases

DrugBankiDB08818. Hyaluronic acid.

Polymorphism and mutation databases

BioMutaiTNFAIP6.
DMDMi68067717.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 171 PublicationAdd BLAST17
ChainiPRO_000002669218 – 277Tumor necrosis factor-inducible gene 6 proteinAdd BLAST260

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi58 ↔ 127
Disulfide bondi82 ↔ 103
Glycosylationi118N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi135 ↔ 161By similarity
Disulfide bondi188 ↔ 210By similarity
Glycosylationi258N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP98066.
PeptideAtlasiP98066.
PRIDEiP98066.

PTM databases

iPTMnetiP98066.
PhosphoSitePlusiP98066.

Expressioni

Tissue specificityi

Found in the synovial fluid of patients with rheumatoid arthritis.1 Publication

Inductioni

By TNF.

Gene expression databases

BgeeiENSG00000123610.
CleanExiHS_TNFAIP6.
GenevisibleiP98066. HS.

Organism-specific databases

HPAiCAB032719.
HPA050884.

Interactioni

Subunit structurei

Interacts with inter-alpha-inhibitor (I-alpha-I). Chondroitin sulfate may be required for the stability of the complex.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
CCL19Q997312EBI-11700693,EBI-11711510
CCL2P135002EBI-11700693,EBI-11711396
CCL7P800982EBI-11700693,EBI-11711410
CXCL11O146252EBI-11700693,EBI-11711364
CXCL8P1014515EBI-11700693,EBI-3917999
FN1P027518EBI-11700693,EBI-1220319
PTX3P260228EBI-11700693,EBI-11574553

Protein-protein interaction databases

BioGridi112984. 2 interactors.
IntActiP98066. 17 interactors.
STRINGi9606.ENSP00000243347.

Structurei

Secondary structure

1277
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi37 – 40Combined sources4
Beta strandi42 – 44Combined sources3
Beta strandi45 – 47Combined sources3
Helixi51 – 60Combined sources10
Helixi68 – 76Combined sources9
Beta strandi85 – 87Combined sources3
Helixi88 – 90Combined sources3
Beta strandi91 – 97Combined sources7
Turni101 – 103Combined sources3
Beta strandi109 – 115Combined sources7
Beta strandi123 – 128Combined sources6
Beta strandi137 – 139Combined sources3
Beta strandi141 – 147Combined sources7
Turni149 – 152Combined sources4
Beta strandi160 – 166Combined sources7
Beta strandi172 – 181Combined sources10
Beta strandi190 – 209Combined sources20
Beta strandi211 – 213Combined sources3
Beta strandi221 – 230Combined sources10
Beta strandi239 – 247Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1O7BNMR-T36-133[»]
1O7CNMR-T36-133[»]
2N40NMR-A36-133[»]
2PF5X-ray1.90A/B/C/D/E36-133[»]
2WNOX-ray2.30A129-277[»]
ProteinModelPortaliP98066.
SMRiP98066.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP98066.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini36 – 129LinkPROSITE-ProRule annotationAdd BLAST94
Domaini135 – 247CUBPROSITE-ProRule annotationAdd BLAST113

Sequence similaritiesi

Contains 1 CUB domain.PROSITE-ProRule annotation
Contains 1 Link domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1218. Eukaryota.
KOG3714. Eukaryota.
ENOG410ZI1H. LUCA.
GeneTreeiENSGT00760000119025.
HOGENOMiHOG000043074.
HOVERGENiHBG006669.
InParanoidiP98066.
KOiK19018.
OMAiGHLATYK.
OrthoDBiEOG091G09EL.
PhylomeDBiP98066.
TreeFamiTF334173.

Family and domain databases

CDDicd00041. CUB. 1 hit.
Gene3Di2.60.120.290. 1 hit.
3.10.100.10. 1 hit.
InterProiIPR016186. C-type_lectin-like/link.
IPR016187. CTDL_fold.
IPR000859. CUB_dom.
IPR000538. Link_dom.
[Graphical view]
PfamiPF00431. CUB. 1 hit.
PF00193. Xlink. 1 hit.
[Graphical view]
PRINTSiPR01265. LINKMODULE.
SMARTiSM00042. CUB. 1 hit.
SM00445. LINK. 1 hit.
[Graphical view]
SUPFAMiSSF49854. SSF49854. 1 hit.
SSF56436. SSF56436. 1 hit.
PROSITEiPS01180. CUB. 1 hit.
PS01241. LINK_1. 1 hit.
PS50963. LINK_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P98066-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIILIYLFLL LWEDTQGWGF KDGIFHNSIW LERAAGVYHR EARSGKYKLT
60 70 80 90 100
YAEAKAVCEF EGGHLATYKQ LEAARKIGFH VCAAGWMAKG RVGYPIVKPG
110 120 130 140 150
PNCGFGKTGI IDYGIRLNRS ERWDAYCYNP HAKECGGVFT DPKQIFKSPG
160 170 180 190 200
FPNEYEDNQI CYWHIRLKYG QRIHLSFLDF DLEDDPGCLA DYVEIYDSYD
210 220 230 240 250
DVHGFVGRYC GDELPDDIIS TGNVMTLKFL SDASVTAGGF QIKYVAMDPV
260 270
SKSSQGKNTS TTSTGNKNFL AGRFSHL
Length:277
Mass (Da):31,203
Last modified:June 21, 2005 - v2
Checksum:iE2B3AEB76353A782
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_013005144Q → R.2 PublicationsCorresponds to variant rs1046668dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M31165 mRNA. Translation: AAB00792.1.
AJ421518 mRNA. Translation: CAD13434.1.
AJ419936 mRNA. Translation: CAD12353.1.
AC009311 Genomic DNA. Translation: AAY15067.1.
CH471058 Genomic DNA. Translation: EAX11511.1.
BC030205 mRNA. Translation: AAH30205.1.
CCDSiCCDS2193.1.
PIRiA41735.
RefSeqiNP_009046.2. NM_007115.3.
UniGeneiHs.437322.

Genome annotation databases

EnsembliENST00000243347; ENSP00000243347; ENSG00000123610.
GeneIDi7130.
KEGGihsa:7130.
UCSCiuc002txk.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M31165 mRNA. Translation: AAB00792.1.
AJ421518 mRNA. Translation: CAD13434.1.
AJ419936 mRNA. Translation: CAD12353.1.
AC009311 Genomic DNA. Translation: AAY15067.1.
CH471058 Genomic DNA. Translation: EAX11511.1.
BC030205 mRNA. Translation: AAH30205.1.
CCDSiCCDS2193.1.
PIRiA41735.
RefSeqiNP_009046.2. NM_007115.3.
UniGeneiHs.437322.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1O7BNMR-T36-133[»]
1O7CNMR-T36-133[»]
2N40NMR-A36-133[»]
2PF5X-ray1.90A/B/C/D/E36-133[»]
2WNOX-ray2.30A129-277[»]
ProteinModelPortaliP98066.
SMRiP98066.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112984. 2 interactors.
IntActiP98066. 17 interactors.
STRINGi9606.ENSP00000243347.

Chemistry databases

DrugBankiDB08818. Hyaluronic acid.

PTM databases

iPTMnetiP98066.
PhosphoSitePlusiP98066.

Polymorphism and mutation databases

BioMutaiTNFAIP6.
DMDMi68067717.

Proteomic databases

PaxDbiP98066.
PeptideAtlasiP98066.
PRIDEiP98066.

Protocols and materials databases

DNASUi7130.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000243347; ENSP00000243347; ENSG00000123610.
GeneIDi7130.
KEGGihsa:7130.
UCSCiuc002txk.3. human.

Organism-specific databases

CTDi7130.
DisGeNETi7130.
GeneCardsiTNFAIP6.
HGNCiHGNC:11898. TNFAIP6.
HPAiCAB032719.
HPA050884.
MIMi600410. gene.
neXtProtiNX_P98066.
OpenTargetsiENSG00000123610.
PharmGKBiPA36595.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1218. Eukaryota.
KOG3714. Eukaryota.
ENOG410ZI1H. LUCA.
GeneTreeiENSGT00760000119025.
HOGENOMiHOG000043074.
HOVERGENiHBG006669.
InParanoidiP98066.
KOiK19018.
OMAiGHLATYK.
OrthoDBiEOG091G09EL.
PhylomeDBiP98066.
TreeFamiTF334173.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000123610-MONOMER.
ReactomeiR-HSA-6798695. Neutrophil degranulation.

Miscellaneous databases

EvolutionaryTraceiP98066.
GeneWikiiTSG-6.
GenomeRNAii7130.
PROiP98066.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000123610.
CleanExiHS_TNFAIP6.
GenevisibleiP98066. HS.

Family and domain databases

CDDicd00041. CUB. 1 hit.
Gene3Di2.60.120.290. 1 hit.
3.10.100.10. 1 hit.
InterProiIPR016186. C-type_lectin-like/link.
IPR016187. CTDL_fold.
IPR000859. CUB_dom.
IPR000538. Link_dom.
[Graphical view]
PfamiPF00431. CUB. 1 hit.
PF00193. Xlink. 1 hit.
[Graphical view]
PRINTSiPR01265. LINKMODULE.
SMARTiSM00042. CUB. 1 hit.
SM00445. LINK. 1 hit.
[Graphical view]
SUPFAMiSSF49854. SSF49854. 1 hit.
SSF56436. SSF56436. 1 hit.
PROSITEiPS01180. CUB. 1 hit.
PS01241. LINK_1. 1 hit.
PS50963. LINK_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTSG6_HUMAN
AccessioniPrimary (citable) accession number: P98066
Secondary accession number(s): Q53TI7, Q8WWI9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: June 21, 2005
Last modified: November 30, 2016
This is version 157 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.