Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P98066 (TSG6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 135. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tumor necrosis factor-inducible gene 6 protein
Alternative name(s):
Hyaluronate-binding protein
TNF-stimulated gene 6 protein
Short name=TSG-6
Tumor necrosis factor alpha-induced protein 6
Short name=TNF alpha-induced protein 6
Gene names
Name:TNFAIP6
Synonyms:TSG6
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length277 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Possibly involved in cell-cell and cell-matrix interactions during inflammation and tumorigenesis.

Subunit structure

Interacts with inter-alpha-inhibitor (I-alpha-I). Chondroitin sulfate may be required for the stability of the complex. Ref.6

Tissue specificity

Found in the synovial fluid of patients with rheumatoid arthritis. Ref.6

Induction

By TNF.

Sequence similarities

Contains 1 CUB domain.

Contains 1 Link domain.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1717 Ref.6
Chain18 – 277260Tumor necrosis factor-inducible gene 6 protein
PRO_0000026692

Regions

Domain36 – 12994Link
Domain135 – 247113CUB

Amino acid modifications

Glycosylation1181N-linked (GlcNAc...) Potential
Glycosylation2581N-linked (GlcNAc...) Potential
Disulfide bond58 ↔ 127
Disulfide bond82 ↔ 103
Disulfide bond135 ↔ 161 By similarity
Disulfide bond188 ↔ 210 By similarity

Natural variations

Natural variant1441Q → R. Ref.1 Ref.5
Corresponds to variant rs1046668 [ dbSNP | Ensembl ].
VAR_013005

Secondary structure

...................................... 277
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P98066 [UniParc].

Last modified June 21, 2005. Version 2.
Checksum: E2B3AEB76353A782

FASTA27731,203
        10         20         30         40         50         60 
MIILIYLFLL LWEDTQGWGF KDGIFHNSIW LERAAGVYHR EARSGKYKLT YAEAKAVCEF 

        70         80         90        100        110        120 
EGGHLATYKQ LEAARKIGFH VCAAGWMAKG RVGYPIVKPG PNCGFGKTGI IDYGIRLNRS 

       130        140        150        160        170        180 
ERWDAYCYNP HAKECGGVFT DPKQIFKSPG FPNEYEDNQI CYWHIRLKYG QRIHLSFLDF 

       190        200        210        220        230        240 
DLEDDPGCLA DYVEIYDSYD DVHGFVGRYC GDELPDDIIS TGNVMTLKFL SDASVTAGGF 

       250        260        270 
QIKYVAMDPV SKSSQGKNTS TTSTGNKNFL AGRFSHL 

« Hide

References

« Hide 'large scale' references
[1]"A novel secretory tumor necrosis factor-inducible protein (TSG-6) is a member of the family of hyaluronate binding proteins, closely related to the adhesion receptor CD44."
Lee T.H., Wisniewski H.-G., Vilcek J.
J. Cell Biol. 116:545-557(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ARG-144.
Tissue: Fibroblast.
[2]"A novel allelic variant of the human TSG-6 gene encoding an amino acid difference in the CUB module. Chromosomal localization, frequency analysis, modeling, and expression."
Nentwich H.A., Mustafa Z., Rugg M.S., Marsden B.D., Cordell M.R., Mahoney D.J., Jenkins S.C., Dowling B., Fries E., Milner C.M., Loughlin J., Day A.J.
J. Biol. Chem. 277:15354-15362(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-144.
Tissue: Lung and Spleen.
[6]"TSG-6, an arthritis-associated hyaluronan binding protein, forms a stable complex with the serum protein inter-alpha-inhibitor."
Wisniewski H.-G., Burgess W.H., Oppenheim J.D., Vilcek J.
Biochemistry 33:7423-7429(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 18-27, TISSUE SPECIFICITY, INTERACTION WITH INTER-ALPHA-INHIBITOR.
[7]"Solution structure of the link module: a hyaluronan-binding domain involved in extracellular matrix stability and cell migration."
Kohda D., Morton C.J., Parkar A.A., Hatanaka H., Inagaki F.M., Campbell I.D., Day A.J.
Cell 86:767-775(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE BY NMR OF 36-133.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M31165 mRNA. Translation: AAB00792.1.
AJ421518 mRNA. Translation: CAD13434.1.
AJ419936 mRNA. Translation: CAD12353.1.
AC009311 Genomic DNA. Translation: AAY15067.1.
CH471058 Genomic DNA. Translation: EAX11511.1.
BC030205 mRNA. Translation: AAH30205.1.
CCDSCCDS2193.1.
PIRA41735.
RefSeqNP_009046.2. NM_007115.3.
UniGeneHs.437322.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1O7BNMR-T36-133[»]
1O7CNMR-T36-133[»]
2PF5X-ray1.90A/B/C/D/E36-133[»]
2WNOX-ray2.30A129-277[»]
ProteinModelPortalP98066.
SMRP98066. Positions 36-249.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid112984. 2 interactions.
STRING9606.ENSP00000243347.

PTM databases

PhosphoSiteP98066.

Polymorphism databases

DMDM68067717.

Proteomic databases

PaxDbP98066.
PRIDEP98066.

Protocols and materials databases

DNASU7130.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000243347; ENSP00000243347; ENSG00000123610.
GeneID7130.
KEGGhsa:7130.
UCSCuc002txk.3. human.

Organism-specific databases

CTD7130.
GeneCardsGC02P152178.
HGNCHGNC:11898. TNFAIP6.
HPACAB032719.
HPA007896.
MIM600410. gene.
neXtProtNX_P98066.
PharmGKBPA36595.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG237473.
HOGENOMHOG000043074.
HOVERGENHBG006669.
InParanoidP98066.
OMAKECGGVF.
OrthoDBEOG7Q5HF0.
PhylomeDBP98066.
TreeFamTF334173.

Gene expression databases

BgeeP98066.
CleanExHS_TNFAIP6.
GenevestigatorP98066.

Family and domain databases

Gene3D2.60.120.290. 1 hit.
3.10.100.10. 1 hit.
InterProIPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
IPR000859. CUB_dom.
IPR000538. Link.
[Graphical view]
PfamPF00431. CUB. 1 hit.
PF00193. Xlink. 1 hit.
[Graphical view]
PRINTSPR01265. LINKMODULE.
SMARTSM00042. CUB. 1 hit.
SM00445. LINK. 1 hit.
[Graphical view]
SUPFAMSSF49854. SSF49854. 1 hit.
SSF56436. SSF56436. 1 hit.
PROSITEPS01180. CUB. 1 hit.
PS01241. LINK_1. 1 hit.
PS50963. LINK_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP98066.
GeneWikiTSG-6.
GenomeRNAi7130.
NextBio27899.
PROP98066.
SOURCESearch...

Entry information

Entry nameTSG6_HUMAN
AccessionPrimary (citable) accession number: P98066
Secondary accession number(s): Q53TI7, Q8WWI9
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: June 21, 2005
Last modified: July 9, 2014
This is version 135 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM