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Protein

Tumor necrosis factor-inducible gene 6 protein

Gene

TNFAIP6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Possibly involved in cell-cell and cell-matrix interactions during inflammation and tumorigenesis.

GO - Molecular functioni

  • hyaluronic acid binding Source: ProtInc

GO - Biological processi

  • cell adhesion Source: UniProtKB-KW
  • cell-cell signaling Source: ProtInc
  • inflammatory response Source: ProtInc
  • negative regulation of inflammatory response Source: CACAO
  • ovulation Source: Ensembl
  • positive regulation of cell migration Source: Ensembl
  • signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor-inducible gene 6 protein
Alternative name(s):
Hyaluronate-binding protein
TNF-stimulated gene 6 protein
Short name:
TSG-6
Tumor necrosis factor alpha-induced protein 6
Short name:
TNF alpha-induced protein 6
Gene namesi
Name:TNFAIP6
Synonyms:TSG6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:11898. TNFAIP6.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36595.

Chemistry

DrugBankiDB08818. Hyaluronan.

Polymorphism and mutation databases

BioMutaiTNFAIP6.
DMDMi68067717.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 17171 PublicationAdd
BLAST
Chaini18 – 277260Tumor necrosis factor-inducible gene 6 proteinPRO_0000026692Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi58 ↔ 127
Disulfide bondi82 ↔ 103
Glycosylationi118 – 1181N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi135 ↔ 161By similarity
Disulfide bondi188 ↔ 210By similarity
Glycosylationi258 – 2581N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP98066.
PRIDEiP98066.

PTM databases

PhosphoSiteiP98066.

Expressioni

Tissue specificityi

Found in the synovial fluid of patients with rheumatoid arthritis.1 Publication

Inductioni

By TNF.

Gene expression databases

BgeeiP98066.
CleanExiHS_TNFAIP6.
GenevisibleiP98066. HS.

Organism-specific databases

HPAiCAB032719.
HPA007896.
HPA050884.

Interactioni

Subunit structurei

Interacts with inter-alpha-inhibitor (I-alpha-I). Chondroitin sulfate may be required for the stability of the complex.1 Publication

Protein-protein interaction databases

BioGridi112984. 2 interactions.
STRINGi9606.ENSP00000243347.

Structurei

Secondary structure

1
277
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi37 – 404Combined sources
Beta strandi42 – 443Combined sources
Beta strandi45 – 473Combined sources
Helixi51 – 6010Combined sources
Helixi68 – 769Combined sources
Beta strandi85 – 873Combined sources
Helixi88 – 903Combined sources
Beta strandi91 – 977Combined sources
Turni101 – 1033Combined sources
Beta strandi109 – 1157Combined sources
Beta strandi123 – 1286Combined sources
Beta strandi137 – 1393Combined sources
Beta strandi141 – 1477Combined sources
Turni149 – 1524Combined sources
Beta strandi160 – 1667Combined sources
Beta strandi172 – 18110Combined sources
Beta strandi190 – 20920Combined sources
Beta strandi211 – 2133Combined sources
Beta strandi221 – 23010Combined sources
Beta strandi239 – 2479Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1O7BNMR-T36-133[»]
1O7CNMR-T36-133[»]
2PF5X-ray1.90A/B/C/D/E36-133[»]
2WNOX-ray2.30A129-277[»]
ProteinModelPortaliP98066.
SMRiP98066. Positions 36-249.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP98066.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini36 – 12994LinkPROSITE-ProRule annotationAdd
BLAST
Domaini135 – 247113CUBPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 CUB domain.PROSITE-ProRule annotation
Contains 1 Link domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG237473.
GeneTreeiENSGT00730000110695.
HOGENOMiHOG000043074.
HOVERGENiHBG006669.
InParanoidiP98066.
KOiK19018.
OMAiKECGGVF.
OrthoDBiEOG7Q5HF0.
PhylomeDBiP98066.
TreeFamiTF334173.

Family and domain databases

Gene3Di2.60.120.290. 1 hit.
3.10.100.10. 1 hit.
InterProiIPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
IPR000859. CUB_dom.
IPR000538. Link.
[Graphical view]
PfamiPF00431. CUB. 1 hit.
PF00193. Xlink. 1 hit.
[Graphical view]
PRINTSiPR01265. LINKMODULE.
SMARTiSM00042. CUB. 1 hit.
SM00445. LINK. 1 hit.
[Graphical view]
SUPFAMiSSF49854. SSF49854. 1 hit.
SSF56436. SSF56436. 1 hit.
PROSITEiPS01180. CUB. 1 hit.
PS01241. LINK_1. 1 hit.
PS50963. LINK_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P98066-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIILIYLFLL LWEDTQGWGF KDGIFHNSIW LERAAGVYHR EARSGKYKLT
60 70 80 90 100
YAEAKAVCEF EGGHLATYKQ LEAARKIGFH VCAAGWMAKG RVGYPIVKPG
110 120 130 140 150
PNCGFGKTGI IDYGIRLNRS ERWDAYCYNP HAKECGGVFT DPKQIFKSPG
160 170 180 190 200
FPNEYEDNQI CYWHIRLKYG QRIHLSFLDF DLEDDPGCLA DYVEIYDSYD
210 220 230 240 250
DVHGFVGRYC GDELPDDIIS TGNVMTLKFL SDASVTAGGF QIKYVAMDPV
260 270
SKSSQGKNTS TTSTGNKNFL AGRFSHL
Length:277
Mass (Da):31,203
Last modified:June 21, 2005 - v2
Checksum:iE2B3AEB76353A782
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti144 – 1441Q → R.2 Publications
Corresponds to variant rs1046668 [ dbSNP | Ensembl ].
VAR_013005

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M31165 mRNA. Translation: AAB00792.1.
AJ421518 mRNA. Translation: CAD13434.1.
AJ419936 mRNA. Translation: CAD12353.1.
AC009311 Genomic DNA. Translation: AAY15067.1.
CH471058 Genomic DNA. Translation: EAX11511.1.
BC030205 mRNA. Translation: AAH30205.1.
CCDSiCCDS2193.1.
PIRiA41735.
RefSeqiNP_009046.2. NM_007115.3.
UniGeneiHs.437322.

Genome annotation databases

EnsembliENST00000243347; ENSP00000243347; ENSG00000123610.
GeneIDi7130.
KEGGihsa:7130.
UCSCiuc002txk.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M31165 mRNA. Translation: AAB00792.1.
AJ421518 mRNA. Translation: CAD13434.1.
AJ419936 mRNA. Translation: CAD12353.1.
AC009311 Genomic DNA. Translation: AAY15067.1.
CH471058 Genomic DNA. Translation: EAX11511.1.
BC030205 mRNA. Translation: AAH30205.1.
CCDSiCCDS2193.1.
PIRiA41735.
RefSeqiNP_009046.2. NM_007115.3.
UniGeneiHs.437322.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1O7BNMR-T36-133[»]
1O7CNMR-T36-133[»]
2PF5X-ray1.90A/B/C/D/E36-133[»]
2WNOX-ray2.30A129-277[»]
ProteinModelPortaliP98066.
SMRiP98066. Positions 36-249.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112984. 2 interactions.
STRINGi9606.ENSP00000243347.

Chemistry

DrugBankiDB08818. Hyaluronan.

PTM databases

PhosphoSiteiP98066.

Polymorphism and mutation databases

BioMutaiTNFAIP6.
DMDMi68067717.

Proteomic databases

PaxDbiP98066.
PRIDEiP98066.

Protocols and materials databases

DNASUi7130.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000243347; ENSP00000243347; ENSG00000123610.
GeneIDi7130.
KEGGihsa:7130.
UCSCiuc002txk.3. human.

Organism-specific databases

CTDi7130.
GeneCardsiGC02P152178.
HGNCiHGNC:11898. TNFAIP6.
HPAiCAB032719.
HPA007896.
HPA050884.
MIMi600410. gene.
neXtProtiNX_P98066.
PharmGKBiPA36595.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG237473.
GeneTreeiENSGT00730000110695.
HOGENOMiHOG000043074.
HOVERGENiHBG006669.
InParanoidiP98066.
KOiK19018.
OMAiKECGGVF.
OrthoDBiEOG7Q5HF0.
PhylomeDBiP98066.
TreeFamiTF334173.

Miscellaneous databases

EvolutionaryTraceiP98066.
GeneWikiiTSG-6.
GenomeRNAii7130.
NextBioi27899.
PROiP98066.
SOURCEiSearch...

Gene expression databases

BgeeiP98066.
CleanExiHS_TNFAIP6.
GenevisibleiP98066. HS.

Family and domain databases

Gene3Di2.60.120.290. 1 hit.
3.10.100.10. 1 hit.
InterProiIPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
IPR000859. CUB_dom.
IPR000538. Link.
[Graphical view]
PfamiPF00431. CUB. 1 hit.
PF00193. Xlink. 1 hit.
[Graphical view]
PRINTSiPR01265. LINKMODULE.
SMARTiSM00042. CUB. 1 hit.
SM00445. LINK. 1 hit.
[Graphical view]
SUPFAMiSSF49854. SSF49854. 1 hit.
SSF56436. SSF56436. 1 hit.
PROSITEiPS01180. CUB. 1 hit.
PS01241. LINK_1. 1 hit.
PS50963. LINK_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A novel secretory tumor necrosis factor-inducible protein (TSG-6) is a member of the family of hyaluronate binding proteins, closely related to the adhesion receptor CD44."
    Lee T.H., Wisniewski H.-G., Vilcek J.
    J. Cell Biol. 116:545-557(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ARG-144.
    Tissue: Fibroblast.
  2. "A novel allelic variant of the human TSG-6 gene encoding an amino acid difference in the CUB module. Chromosomal localization, frequency analysis, modeling, and expression."
    Nentwich H.A., Mustafa Z., Rugg M.S., Marsden B.D., Cordell M.R., Mahoney D.J., Jenkins S.C., Dowling B., Fries E., Milner C.M., Loughlin J., Day A.J.
    J. Biol. Chem. 277:15354-15362(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-144.
    Tissue: Lung and Spleen.
  6. "TSG-6, an arthritis-associated hyaluronan binding protein, forms a stable complex with the serum protein inter-alpha-inhibitor."
    Wisniewski H.-G., Burgess W.H., Oppenheim J.D., Vilcek J.
    Biochemistry 33:7423-7429(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 18-27, TISSUE SPECIFICITY, INTERACTION WITH INTER-ALPHA-INHIBITOR.
  7. "Solution structure of the link module: a hyaluronan-binding domain involved in extracellular matrix stability and cell migration."
    Kohda D., Morton C.J., Parkar A.A., Hatanaka H., Inagaki F.M., Campbell I.D., Day A.J.
    Cell 86:767-775(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 36-133.

Entry informationi

Entry nameiTSG6_HUMAN
AccessioniPrimary (citable) accession number: P98066
Secondary accession number(s): Q53TI7, Q8WWI9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: June 21, 2005
Last modified: June 24, 2015
This is version 142 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.