Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P98066

- TSG6_HUMAN

UniProt

P98066 - TSG6_HUMAN

Protein

Tumor necrosis factor-inducible gene 6 protein

Gene

TNFAIP6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 136 (01 Oct 2014)
      Sequence version 2 (21 Jun 2005)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Possibly involved in cell-cell and cell-matrix interactions during inflammation and tumorigenesis.

    GO - Molecular functioni

    1. hyaluronic acid binding Source: ProtInc

    GO - Biological processi

    1. cell adhesion Source: UniProtKB-KW
    2. cell-cell signaling Source: ProtInc
    3. inflammatory response Source: ProtInc
    4. signal transduction Source: ProtInc

    Keywords - Biological processi

    Cell adhesion

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tumor necrosis factor-inducible gene 6 protein
    Alternative name(s):
    Hyaluronate-binding protein
    TNF-stimulated gene 6 protein
    Short name:
    TSG-6
    Tumor necrosis factor alpha-induced protein 6
    Short name:
    TNF alpha-induced protein 6
    Gene namesi
    Name:TNFAIP6
    Synonyms:TSG6
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:11898. TNFAIP6.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA36595.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 17171 PublicationAdd
    BLAST
    Chaini18 – 277260Tumor necrosis factor-inducible gene 6 proteinPRO_0000026692Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi58 ↔ 127
    Disulfide bondi82 ↔ 103
    Glycosylationi118 – 1181N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi135 ↔ 161By similarity
    Disulfide bondi188 ↔ 210By similarity
    Glycosylationi258 – 2581N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP98066.
    PRIDEiP98066.

    PTM databases

    PhosphoSiteiP98066.

    Expressioni

    Tissue specificityi

    Found in the synovial fluid of patients with rheumatoid arthritis.1 Publication

    Inductioni

    By TNF.

    Gene expression databases

    BgeeiP98066.
    CleanExiHS_TNFAIP6.
    GenevestigatoriP98066.

    Organism-specific databases

    HPAiCAB032719.
    HPA007896.

    Interactioni

    Subunit structurei

    Interacts with inter-alpha-inhibitor (I-alpha-I). Chondroitin sulfate may be required for the stability of the complex.1 Publication

    Protein-protein interaction databases

    BioGridi112984. 2 interactions.
    STRINGi9606.ENSP00000243347.

    Structurei

    Secondary structure

    1
    277
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi37 – 404
    Beta strandi42 – 443
    Beta strandi45 – 473
    Helixi51 – 6010
    Helixi68 – 769
    Beta strandi85 – 873
    Helixi88 – 903
    Beta strandi91 – 977
    Turni101 – 1033
    Beta strandi109 – 1157
    Beta strandi123 – 1286
    Beta strandi137 – 1393
    Beta strandi141 – 1477
    Turni149 – 1524
    Beta strandi160 – 1667
    Beta strandi172 – 18110
    Beta strandi190 – 20920
    Beta strandi211 – 2133
    Beta strandi221 – 23010
    Beta strandi239 – 2479

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1O7BNMR-T36-133[»]
    1O7CNMR-T36-133[»]
    2PF5X-ray1.90A/B/C/D/E36-133[»]
    2WNOX-ray2.30A129-277[»]
    ProteinModelPortaliP98066.
    SMRiP98066. Positions 36-249.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP98066.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini36 – 12994LinkPROSITE-ProRule annotationAdd
    BLAST
    Domaini135 – 247113CUBPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 CUB domain.PROSITE-ProRule annotation
    Contains 1 Link domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG237473.
    HOGENOMiHOG000043074.
    HOVERGENiHBG006669.
    InParanoidiP98066.
    OMAiKECGGVF.
    OrthoDBiEOG7Q5HF0.
    PhylomeDBiP98066.
    TreeFamiTF334173.

    Family and domain databases

    Gene3Di2.60.120.290. 1 hit.
    3.10.100.10. 1 hit.
    InterProiIPR016186. C-type_lectin-like.
    IPR016187. C-type_lectin_fold.
    IPR000859. CUB_dom.
    IPR000538. Link.
    [Graphical view]
    PfamiPF00431. CUB. 1 hit.
    PF00193. Xlink. 1 hit.
    [Graphical view]
    PRINTSiPR01265. LINKMODULE.
    SMARTiSM00042. CUB. 1 hit.
    SM00445. LINK. 1 hit.
    [Graphical view]
    SUPFAMiSSF49854. SSF49854. 1 hit.
    SSF56436. SSF56436. 1 hit.
    PROSITEiPS01180. CUB. 1 hit.
    PS01241. LINK_1. 1 hit.
    PS50963. LINK_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P98066-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIILIYLFLL LWEDTQGWGF KDGIFHNSIW LERAAGVYHR EARSGKYKLT    50
    YAEAKAVCEF EGGHLATYKQ LEAARKIGFH VCAAGWMAKG RVGYPIVKPG 100
    PNCGFGKTGI IDYGIRLNRS ERWDAYCYNP HAKECGGVFT DPKQIFKSPG 150
    FPNEYEDNQI CYWHIRLKYG QRIHLSFLDF DLEDDPGCLA DYVEIYDSYD 200
    DVHGFVGRYC GDELPDDIIS TGNVMTLKFL SDASVTAGGF QIKYVAMDPV 250
    SKSSQGKNTS TTSTGNKNFL AGRFSHL 277
    Length:277
    Mass (Da):31,203
    Last modified:June 21, 2005 - v2
    Checksum:iE2B3AEB76353A782
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti144 – 1441Q → R.2 Publications
    Corresponds to variant rs1046668 [ dbSNP | Ensembl ].
    VAR_013005

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M31165 mRNA. Translation: AAB00792.1.
    AJ421518 mRNA. Translation: CAD13434.1.
    AJ419936 mRNA. Translation: CAD12353.1.
    AC009311 Genomic DNA. Translation: AAY15067.1.
    CH471058 Genomic DNA. Translation: EAX11511.1.
    BC030205 mRNA. Translation: AAH30205.1.
    CCDSiCCDS2193.1.
    PIRiA41735.
    RefSeqiNP_009046.2. NM_007115.3.
    UniGeneiHs.437322.

    Genome annotation databases

    EnsembliENST00000243347; ENSP00000243347; ENSG00000123610.
    GeneIDi7130.
    KEGGihsa:7130.
    UCSCiuc002txk.3. human.

    Polymorphism databases

    DMDMi68067717.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M31165 mRNA. Translation: AAB00792.1 .
    AJ421518 mRNA. Translation: CAD13434.1 .
    AJ419936 mRNA. Translation: CAD12353.1 .
    AC009311 Genomic DNA. Translation: AAY15067.1 .
    CH471058 Genomic DNA. Translation: EAX11511.1 .
    BC030205 mRNA. Translation: AAH30205.1 .
    CCDSi CCDS2193.1.
    PIRi A41735.
    RefSeqi NP_009046.2. NM_007115.3.
    UniGenei Hs.437322.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1O7B NMR - T 36-133 [» ]
    1O7C NMR - T 36-133 [» ]
    2PF5 X-ray 1.90 A/B/C/D/E 36-133 [» ]
    2WNO X-ray 2.30 A 129-277 [» ]
    ProteinModelPortali P98066.
    SMRi P98066. Positions 36-249.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112984. 2 interactions.
    STRINGi 9606.ENSP00000243347.

    PTM databases

    PhosphoSitei P98066.

    Polymorphism databases

    DMDMi 68067717.

    Proteomic databases

    PaxDbi P98066.
    PRIDEi P98066.

    Protocols and materials databases

    DNASUi 7130.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000243347 ; ENSP00000243347 ; ENSG00000123610 .
    GeneIDi 7130.
    KEGGi hsa:7130.
    UCSCi uc002txk.3. human.

    Organism-specific databases

    CTDi 7130.
    GeneCardsi GC02P152178.
    HGNCi HGNC:11898. TNFAIP6.
    HPAi CAB032719.
    HPA007896.
    MIMi 600410. gene.
    neXtProti NX_P98066.
    PharmGKBi PA36595.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG237473.
    HOGENOMi HOG000043074.
    HOVERGENi HBG006669.
    InParanoidi P98066.
    OMAi KECGGVF.
    OrthoDBi EOG7Q5HF0.
    PhylomeDBi P98066.
    TreeFami TF334173.

    Miscellaneous databases

    EvolutionaryTracei P98066.
    GeneWikii TSG-6.
    GenomeRNAii 7130.
    NextBioi 27899.
    PROi P98066.
    SOURCEi Search...

    Gene expression databases

    Bgeei P98066.
    CleanExi HS_TNFAIP6.
    Genevestigatori P98066.

    Family and domain databases

    Gene3Di 2.60.120.290. 1 hit.
    3.10.100.10. 1 hit.
    InterProi IPR016186. C-type_lectin-like.
    IPR016187. C-type_lectin_fold.
    IPR000859. CUB_dom.
    IPR000538. Link.
    [Graphical view ]
    Pfami PF00431. CUB. 1 hit.
    PF00193. Xlink. 1 hit.
    [Graphical view ]
    PRINTSi PR01265. LINKMODULE.
    SMARTi SM00042. CUB. 1 hit.
    SM00445. LINK. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49854. SSF49854. 1 hit.
    SSF56436. SSF56436. 1 hit.
    PROSITEi PS01180. CUB. 1 hit.
    PS01241. LINK_1. 1 hit.
    PS50963. LINK_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel secretory tumor necrosis factor-inducible protein (TSG-6) is a member of the family of hyaluronate binding proteins, closely related to the adhesion receptor CD44."
      Lee T.H., Wisniewski H.-G., Vilcek J.
      J. Cell Biol. 116:545-557(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ARG-144.
      Tissue: Fibroblast.
    2. "A novel allelic variant of the human TSG-6 gene encoding an amino acid difference in the CUB module. Chromosomal localization, frequency analysis, modeling, and expression."
      Nentwich H.A., Mustafa Z., Rugg M.S., Marsden B.D., Cordell M.R., Mahoney D.J., Jenkins S.C., Dowling B., Fries E., Milner C.M., Loughlin J., Day A.J.
      J. Biol. Chem. 277:15354-15362(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-144.
      Tissue: Lung and Spleen.
    6. "TSG-6, an arthritis-associated hyaluronan binding protein, forms a stable complex with the serum protein inter-alpha-inhibitor."
      Wisniewski H.-G., Burgess W.H., Oppenheim J.D., Vilcek J.
      Biochemistry 33:7423-7429(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 18-27, TISSUE SPECIFICITY, INTERACTION WITH INTER-ALPHA-INHIBITOR.
    7. "Solution structure of the link module: a hyaluronan-binding domain involved in extracellular matrix stability and cell migration."
      Kohda D., Morton C.J., Parkar A.A., Hatanaka H., Inagaki F.M., Campbell I.D., Day A.J.
      Cell 86:767-775(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 36-133.

    Entry informationi

    Entry nameiTSG6_HUMAN
    AccessioniPrimary (citable) accession number: P98066
    Secondary accession number(s): Q53TI7, Q8WWI9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: June 21, 2005
    Last modified: October 1, 2014
    This is version 136 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3