SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P98063

- BMP1_MOUSE

UniProt

P98063 - BMP1_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Bone morphogenetic protein 1
Gene
Bmp1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Cleaves the C-terminal propeptides of procollagen I, II and III. Induces cartilage and bone formation. May participate in dorsoventral patterning during early development by cleaving chordin (CHRD) By similarity. Responsible for the proteolytic activation of lysyl oxidase LOX.1 Publication

Catalytic activityi

Cleavage of the C-terminal propeptide at Ala-|-Asp in type I and II procollagens and at Arg-|-Asp in type III.

Cofactori

Binds 1 zinc ion per subunit By similarity.

Enzyme regulationi

Activity is increased by the procollagen C-endopeptidase enhancer protein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi218 – 2181Zinc; catalytic By similarity
Active sitei219 – 2191 By similarity
Metal bindingi222 – 2221Zinc; catalytic By similarity
Metal bindingi228 – 2281Zinc; catalytic By similarity

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. metalloendopeptidase activity Source: MGI
  3. peptidase activity Source: MGI
  4. protein binding Source: MGI
  5. zinc ion binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. cartilage development Source: UniProtKB-KW
  2. cell differentiation Source: UniProtKB-KW
  3. ossification Source: UniProtKB-KW
  4. positive regulation of cartilage development Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Developmental protein, Growth factor, Hydrolase, Metalloprotease, Protease

Keywords - Biological processi

Chondrogenesis, Differentiation, Osteogenesis

Keywords - Ligandi

Calcium, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_196515. Crosslinking of collagen fibrils.
REACT_196595. Anchoring fibril formation.
REACT_198984. Collagen biosynthesis and modifying enzymes.
REACT_199052. Degradation of the extracellular matrix.
REACT_213857. HDL-mediated lipid transport.

Protein family/group databases

MEROPSiM12.005.

Names & Taxonomyi

Protein namesi
Recommended name:
Bone morphogenetic protein 1 (EC:3.4.24.19)
Short name:
BMP-1
Alternative name(s):
Mammalian tolloid protein
Short name:
mTld
Procollagen C-proteinase
Short name:
PCP
Gene namesi
Name:Bmp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 14

Organism-specific databases

MGIiMGI:88176. Bmp1.

Subcellular locationi

Golgi apparatustrans-Golgi network. Secretedextracellular spaceextracellular matrix
Note: Co-localizes with POSTN in the Golgi.1 Publication

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB-SubCell
  2. extracellular space Source: UniProtKB-KW
  3. membrane-bounded vesicle Source: Ensembl
  4. proteinaceous extracellular matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Golgi apparatus, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525 Reviewed prediction
Add
BLAST
Propeptidei26 – 125100 Reviewed prediction
PRO_0000028891Add
BLAST
Chaini126 – 991866Bone morphogenetic protein 1
PRO_0000028892Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi96 – 961N-linked (GlcNAc...) Reviewed prediction
Glycosylationi147 – 1471N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi188 ↔ 191 By similarity
Disulfide bondi327 ↔ 353 By similarity
Glycosylationi337 – 3371N-linked (GlcNAc...) Reviewed prediction
Glycosylationi368 – 3681N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi380 ↔ 402 By similarity
Disulfide bondi440 ↔ 466 By similarity
Disulfide bondi493 ↔ 515 By similarity
Disulfide bondi556 ↔ 568 By similarity
Disulfide bondi564 ↔ 577 By similarity
Disulfide bondi579 ↔ 592 By similarity
Disulfide bondi596 ↔ 622 By similarity
Glycosylationi604 – 6041N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi649 ↔ 671 By similarity
Disulfide bondi712 ↔ 723 By similarity
Disulfide bondi719 ↔ 732 By similarity
Disulfide bondi734 ↔ 747 By similarity
Disulfide bondi752 ↔ 778 By similarity
Disulfide bondi805 ↔ 827 By similarity
Disulfide bondi865 ↔ 895 By similarity
Disulfide bondi922 ↔ 944 By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PaxDbiP98063.
PRIDEiP98063.

PTM databases

PhosphoSiteiP98063.

Expressioni

Tissue specificityi

At high levels in embryonic maternal deciduum and floor plate region of the neural tube. Less in developing membranous and endochondral bone, submucosa of intestine, dermis of skin and the mesenchyme of spleen and lung.

Gene expression databases

ArrayExpressiP98063.
CleanExiMM_BMP1.
GenevestigatoriP98063.

Interactioni

Subunit structurei

Interacts with POSTN, the interaction promotes deposition on the extracellular matrix.1 Publication

Structurei

3D structure databases

ProteinModelPortaliP98063.
SMRiP98063. Positions 126-981.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini327 – 439113CUB 1
Add
BLAST
Domaini440 – 551112CUB 2
Add
BLAST
Domaini552 – 59342EGF-like 1; calcium-binding Reviewed prediction
Add
BLAST
Domaini596 – 707112CUB 3
Add
BLAST
Domaini708 – 74841EGF-like 2; calcium-binding Reviewed prediction
Add
BLAST
Domaini752 – 864113CUB 4
Add
BLAST
Domaini865 – 981117CUB 5
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni126 – 326201Metalloprotease
Add
BLAST

Sequence similaritiesi

Belongs to the peptidase M12A family.
Contains 5 CUB domains.
Contains 2 EGF-like domains.

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiNOG70307.
GeneTreeiENSGT00750000117289.
HOGENOMiHOG000236339.
HOVERGENiHBG004859.
KOiK05502.
OMAiGRFCGGK.
OrthoDBiEOG7N8ZTV.
TreeFamiTF314351.

Family and domain databases

Gene3Di2.60.120.290. 5 hits.
3.40.390.10. 1 hit.
InterProiIPR015446. BMP_1/tolloid-like.
IPR000859. CUB_dom.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR024079. MetalloPept_cat_dom.
IPR001506. Peptidase_M12A.
IPR006026. Peptidase_Metallo.
[Graphical view]
PfamiPF01400. Astacin. 1 hit.
PF00431. CUB. 5 hits.
PF07645. EGF_CA. 1 hit.
[Graphical view]
PIRSFiPIRSF001199. BMP_1/tolloid-like. 1 hit.
PRINTSiPR00480. ASTACIN.
SMARTiSM00042. CUB. 5 hits.
SM00179. EGF_CA. 2 hits.
SM00235. ZnMc. 1 hit.
[Graphical view]
SUPFAMiSSF49854. SSF49854. 5 hits.
PROSITEiPS00010. ASX_HYDROXYL. 2 hits.
PS01180. CUB. 5 hits.
PS01186. EGF_2. 2 hits.
PS50026. EGF_3. 2 hits.
PS01187. EGF_CA. 2 hits.
PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P98063-1 [UniParc]FASTAAdd to Basket

« Hide

MPGVARPPLP LLSLPLLLLL LLLPRAGRPL DLADYTYDLG EEDAPELLNY    50
KDPCKAAAFL GDIALDEEDL RAFQVQQAAV LRQQTARRPS IKAAGNSSAL 100
GGQGTSGQPQ RESRGRWRGR PRSRRAATSR PERVWPDGVI PFVIGGNFTG 150
SQRAVFRQAM RHWEKHTCVT FLERTDEDSY IVFTYRPCGC CSYVGRRGGG 200
PQAISIGKNC DKFGIVVHEL GHVIGFWHEH TRPDRDRHVS IVRENIQPGQ 250
EYNFLKMEVQ EVESLGETYD FDSIMHYARN TFSRGIFLDT IVPKYEVNGV 300
KPSIGQRTRL SKGDIAQARK LYKCPACGET LQDSTGNFSS PEYPNGYSAH 350
MHCVWRISVT PGEKIILNFT SMDLYRSRLC WYDYVEVRDG FWRKAPLRGR 400
FCGGKLPEPI VSTDSRLWVE FRSSSNWVGK GFFAVYEAIC GGDVKKDNGH 450
IQSPNYPDDY RPSKVCIWRI QVSEGFHVGL TFQSFEIERH DSCAYDYLEV 500
RDGHSESSNL IGRYCGYEKP DDIKSTSSRL WLKFVSDGSI NKAGFAVNFF 550
KEVDECSRPN RGGCEQRCLN TLGSYKCSCD PGYELAPDKR RCEAACGGFL 600
TKLNGSITSP GWPKEYPPNK NCIWQLVAPT QYRISLQFDF FETEGNDVCK 650
YDFVEVRSGL TADSKLHGKF CGSEKPEVIT SQYNNMRVEF KSDNTVSKKG 700
FKAHFFSDKD ECSKDNGGCQ QDCVNTFGSY ECQCRSGFVL HDNKHDCKEA 750
GCEHKVTSTS GTITSPNWPD KYPSKKECTW AISSTPGHRV KLTFVEMDIE 800
SQPECAYDHL EVFDGRDAKA PVLGRFCGSK KPEPVLATGN RMFLRFYSDN 850
SVQRKGFQAS HSTECGGQVR ADVKTKDLYS HAQFGDNNYP GGVDCEWVIV 900
AEEGYGVELV FQTFEVEEET DCGYDYIELF DGYDSTAPRL GRYCGSGPPE 950
EVYSAGDSVL VKFHSDDTIS KKGFHLRYTS TKFQDTLHSR K 991
Length:991
Mass (Da):111,666
Last modified:October 3, 2012 - v2
Checksum:iF838441CF1DA9F1A
GO

Sequence cautioni

The sequence AAA37306.1 differs from that shown. Reason: Frameshift at positions 24 and 61.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti395 – 3973APL → VWV in AAA37306. 1 Publication
Sequence conflicti519 – 5191K → N in AAA37306. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L24755 mRNA. Translation: AAA37306.1. Frameshift.
AC122268 Genomic DNA. No translation available.
BC066062 mRNA. Translation: AAH66062.1.
CCDSiCCDS36972.1.
PIRiI49540.
RefSeqiNP_033885.2. NM_009755.3.
XP_006518523.1. XM_006518460.1.
UniGeneiMm.27757.

Genome annotation databases

EnsembliENSMUST00000022693; ENSMUSP00000022693; ENSMUSG00000022098.
GeneIDi12153.
KEGGimmu:12153.
UCSCiuc007uoc.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L24755 mRNA. Translation: AAA37306.1 . Frameshift.
AC122268 Genomic DNA. No translation available.
BC066062 mRNA. Translation: AAH66062.1 .
CCDSi CCDS36972.1.
PIRi I49540.
RefSeqi NP_033885.2. NM_009755.3.
XP_006518523.1. XM_006518460.1.
UniGenei Mm.27757.

3D structure databases

ProteinModelPortali P98063.
SMRi P98063. Positions 126-981.
ModBasei Search...

Protein family/group databases

MEROPSi M12.005.

PTM databases

PhosphoSitei P98063.

Proteomic databases

PaxDbi P98063.
PRIDEi P98063.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000022693 ; ENSMUSP00000022693 ; ENSMUSG00000022098 .
GeneIDi 12153.
KEGGi mmu:12153.
UCSCi uc007uoc.2. mouse.

Organism-specific databases

CTDi 649.
MGIi MGI:88176. Bmp1.

Phylogenomic databases

eggNOGi NOG70307.
GeneTreei ENSGT00750000117289.
HOGENOMi HOG000236339.
HOVERGENi HBG004859.
KOi K05502.
OMAi GRFCGGK.
OrthoDBi EOG7N8ZTV.
TreeFami TF314351.

Enzyme and pathway databases

Reactomei REACT_196515. Crosslinking of collagen fibrils.
REACT_196595. Anchoring fibril formation.
REACT_198984. Collagen biosynthesis and modifying enzymes.
REACT_199052. Degradation of the extracellular matrix.
REACT_213857. HDL-mediated lipid transport.

Miscellaneous databases

NextBioi 280487.
PROi P98063.
SOURCEi Search...

Gene expression databases

ArrayExpressi P98063.
CleanExi MM_BMP1.
Genevestigatori P98063.

Family and domain databases

Gene3Di 2.60.120.290. 5 hits.
3.40.390.10. 1 hit.
InterProi IPR015446. BMP_1/tolloid-like.
IPR000859. CUB_dom.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR024079. MetalloPept_cat_dom.
IPR001506. Peptidase_M12A.
IPR006026. Peptidase_Metallo.
[Graphical view ]
Pfami PF01400. Astacin. 1 hit.
PF00431. CUB. 5 hits.
PF07645. EGF_CA. 1 hit.
[Graphical view ]
PIRSFi PIRSF001199. BMP_1/tolloid-like. 1 hit.
PRINTSi PR00480. ASTACIN.
SMARTi SM00042. CUB. 5 hits.
SM00179. EGF_CA. 2 hits.
SM00235. ZnMc. 1 hit.
[Graphical view ]
SUPFAMi SSF49854. SSF49854. 5 hits.
PROSITEi PS00010. ASX_HYDROXYL. 2 hits.
PS01180. CUB. 5 hits.
PS01186. EGF_2. 2 hits.
PS50026. EGF_3. 2 hits.
PS01187. EGF_CA. 2 hits.
PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Embryonic expression of mouse bone morphogenetic protein-1 (BMP-1), which is related to the Drosophila dorsoventral gene tolloid and encodes a putative astacin metalloendopeptidase."
    Fukagawa M., Noboru S., Hogan B.L.M., Jones C.M.
    Dev. Biol. 163:175-183(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6.
    Tissue: Embryo.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.
  4. "Interaction between periostin and BMP-1 promotes proteolytic activation of lysyl oxidase."
    Maruhashi T., Kii I., Saito M., Kudo A.
    J. Biol. Chem. 285:13294-13303(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH POSTN, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiBMP1_MOUSE
AccessioniPrimary (citable) accession number: P98063
Secondary accession number(s): Q6NZM2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: October 3, 2012
Last modified: September 3, 2014
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi