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Protein

Cytochrome c oxidase subunit 1

Gene

ctaD

Organism
Rhodobacter capsulatus (Rhodopseudomonas capsulata)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Co I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme a of subunit 1 to the bimetallic center formed by heme a3 and copper B. This cytochrome c oxidase shows proton pump activity across the membrane in addition to the electron transfer.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Protein has several cofactor binding sites:
  • Cu2+By similarityNote: Binds 1 copper ion per subunit, denoted as copper B.By similarity
  • hemeBy similarityNote: Binds 2 heme groups per subunit, denoted as high- and low-spin.By similarity

Pathwayi: oxidative phosphorylation

This protein is involved in the pathway oxidative phosphorylation, which is part of Energy metabolism.
View all proteins of this organism that are known to be involved in the pathway oxidative phosphorylation and in Energy metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi114Iron (low-spin heme axial ligand); via tele nitrogenBy similarity1
Metal bindingi264Copper B; via pros nitrogenBy similarity1
Metal bindingi314Copper B; via tele nitrogenBy similarity1
Metal bindingi315Copper B; via tele nitrogenBy similarity1
Metal bindingi402Iron (high-spin heme axial ligand); via tele nitrogenBy similarity1
Metal bindingi404Iron (low-spin heme axial ligand); via tele nitrogenBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Hydrogen ion transport, Ion transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome BB(3) subunit 1
Cytochrome c oxidase polypeptide I
Gene namesi
Name:ctaD
Synonyms:ccoN
OrganismiRhodobacter capsulatus (Rhodopseudomonas capsulata)
Taxonomic identifieri1061 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRhodobacter

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1 – 21HelicalSequence analysisAdd BLAST21
Transmembranei27 – 47HelicalSequence analysisAdd BLAST21
Transmembranei69 – 89HelicalSequence analysisAdd BLAST21
Transmembranei115 – 135HelicalSequence analysisAdd BLAST21
Transmembranei143 – 163HelicalSequence analysisAdd BLAST21
Transmembranei185 – 205HelicalSequence analysisAdd BLAST21
Transmembranei212 – 232HelicalSequence analysisAdd BLAST21
Transmembranei263 – 283HelicalSequence analysisAdd BLAST21
Transmembranei296 – 316HelicalSequence analysisAdd BLAST21
Transmembranei328 – 348HelicalSequence analysisAdd BLAST21
Transmembranei366 – 386HelicalSequence analysisAdd BLAST21
Transmembranei403 – 423HelicalSequence analysisAdd BLAST21
Transmembranei442 – 462HelicalSequence analysisAdd BLAST21
Transmembranei496 – 516HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001834581 – 532Cytochrome c oxidase subunit 1Add BLAST532

Interactioni

Protein-protein interaction databases

STRINGi272942.RCAP_rcc01157.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105EUH. Bacteria.
COG3278. LUCA.

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023616. Cyt_c_oxase-like_su1_dom.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR004677. Cyt_c_oxidase_cbb3_su1.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
SUPFAMiSSF81442. SSF81442. 1 hit.
TIGRFAMsiTIGR00780. ccoN. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P98059-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWDYVKLVAL GVVAAIAAYA ASQARDLPYM VNMVEVALAA VIALIWVLRT
60 70 80 90 100
MGDPKPSKDE YFDGVIRAGV IATTFWGIVG FLVAVVIAFQ LAFPALNLEF
110 120 130 140 150
GNGMLNFGRL RPLHTSAVIF AFGGNALIAS AFYVVQRTSA ARLFGGTALG
160 170 180 190 200
WFVFWGWQLI IVTAATSYLL GGSQGKEYAE LNWHLDILVA VVWVAYLIAF
210 220 230 240 250
LGTIFKRKEP HIYVANWFYL SFIVTIAMLH IVNNLAVPVS IFGTKSVQLM
260 270 280 290 300
AGVQDAMTQW WYGHNAVGFF LTAGFLGMMY YFVPKQAERP VYSYKLSIVH
310 320 330 340 350
FWALIFLYIW AGPHHLHYTA LPDWASTLGM VMSVILWMPS WGGMINGLMT
360 370 380 390 400
LSGAWDKLRT DPVIRMMVVS IGFYGMSTFE GPMMSIKAVN SLSHYTDWTI
410 420 430 440 450
GHVHSGALGW NGMITFGMLY FLTPRLWGRS GLYSLKLVSW HFWLATIGIV
460 470 480 490 500
LYASAMWVTG IMEGLMWREV DAQGFLVNAF ADTVAAKFPM YVVRGVGGVL
510 520 530
YLLGGLIMAY NLWATVAKQP KTANLAVAVP AE
Length:532
Mass (Da):58,956
Last modified:February 1, 1996 - v1
Checksum:i5B00CE8819D2782C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X80134 Genomic DNA. Translation: CAA56433.1.
PIRiS65858. S49345.
RefSeqiWP_055212924.1. NZ_LLVV01000067.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X80134 Genomic DNA. Translation: CAA56433.1.
PIRiS65858. S49345.
RefSeqiWP_055212924.1. NZ_LLVV01000067.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272942.RCAP_rcc01157.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG4105EUH. Bacteria.
COG3278. LUCA.

Enzyme and pathway databases

UniPathwayiUPA00705.

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023616. Cyt_c_oxase-like_su1_dom.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR004677. Cyt_c_oxidase_cbb3_su1.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
SUPFAMiSSF81442. SSF81442. 1 hit.
TIGRFAMsiTIGR00780. ccoN. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCOX1_RHOCA
AccessioniPrimary (citable) accession number: P98059
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 30, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.