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P98059

- COX1_RHOCA

UniProt

P98059 - COX1_RHOCA

Protein

Cytochrome c oxidase subunit 1

Gene

ctaD

Organism
Rhodobacter capsulatus (Rhodopseudomonas capsulata)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Co I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme a of subunit 1 to the bimetallic center formed by heme a3 and copper B. This cytochrome c oxidase shows proton pump activity across the membrane in addition to the electron transfer.

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    Cofactori

    Binds 1 copper B ion per subunit.
    Binds 2 heme groups per subunit.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi114 – 1141Iron (heme B axial ligand)Curated
    Metal bindingi264 – 2641Copper BCurated
    Metal bindingi314 – 3141Copper BCurated
    Metal bindingi315 – 3151Copper BCurated
    Metal bindingi402 – 4021Iron (high-spin heme B axial ligand)Curated
    Metal bindingi404 – 4041Iron (heme B axial ligand)Curated

    GO - Molecular functioni

    1. cytochrome-c oxidase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    GO - Biological processi

    1. aerobic respiration Source: InterPro
    2. oxidative phosphorylation Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Hydrogen ion transport, Ion transport, Respiratory chain, Transport

    Keywords - Ligandi

    Copper, Heme, Iron, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00705.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome BB(3) subunit 1
    Cytochrome c oxidase polypeptide I
    Gene namesi
    Name:ctaD
    Synonyms:ccoN
    OrganismiRhodobacter capsulatus (Rhodopseudomonas capsulata)
    Taxonomic identifieri1061 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRhodobacter

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane respiratory chain complex IV Source: InterPro

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 532532Cytochrome c oxidase subunit 1PRO_0000183458Add
    BLAST

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei1 – 2121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei27 – 4721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei69 – 8921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei115 – 13521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei143 – 16321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei185 – 20521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei212 – 23221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei263 – 28321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei296 – 31621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei328 – 34821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei366 – 38621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei403 – 42321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei442 – 46221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei496 – 51621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Family and domain databases

    Gene3Di1.20.210.10. 1 hit.
    InterProiIPR000883. COX1.
    IPR023615. Cyt_c_Oxase_su1_BS.
    IPR023616. Cyt_c_Oxase_su1_dom.
    IPR004677. Cyt_c_oxidase_cbb3_su1.
    [Graphical view]
    PANTHERiPTHR10422. PTHR10422. 1 hit.
    PfamiPF00115. COX1. 1 hit.
    [Graphical view]
    SUPFAMiSSF81442. SSF81442. 1 hit.
    TIGRFAMsiTIGR00780. ccoN. 1 hit.
    PROSITEiPS50855. COX1. 1 hit.
    PS00077. COX1_CUB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P98059-1 [UniParc]FASTAAdd to Basket

    « Hide

    MWDYVKLVAL GVVAAIAAYA ASQARDLPYM VNMVEVALAA VIALIWVLRT    50
    MGDPKPSKDE YFDGVIRAGV IATTFWGIVG FLVAVVIAFQ LAFPALNLEF 100
    GNGMLNFGRL RPLHTSAVIF AFGGNALIAS AFYVVQRTSA ARLFGGTALG 150
    WFVFWGWQLI IVTAATSYLL GGSQGKEYAE LNWHLDILVA VVWVAYLIAF 200
    LGTIFKRKEP HIYVANWFYL SFIVTIAMLH IVNNLAVPVS IFGTKSVQLM 250
    AGVQDAMTQW WYGHNAVGFF LTAGFLGMMY YFVPKQAERP VYSYKLSIVH 300
    FWALIFLYIW AGPHHLHYTA LPDWASTLGM VMSVILWMPS WGGMINGLMT 350
    LSGAWDKLRT DPVIRMMVVS IGFYGMSTFE GPMMSIKAVN SLSHYTDWTI 400
    GHVHSGALGW NGMITFGMLY FLTPRLWGRS GLYSLKLVSW HFWLATIGIV 450
    LYASAMWVTG IMEGLMWREV DAQGFLVNAF ADTVAAKFPM YVVRGVGGVL 500
    YLLGGLIMAY NLWATVAKQP KTANLAVAVP AE 532
    Length:532
    Mass (Da):58,956
    Last modified:February 1, 1996 - v1
    Checksum:i5B00CE8819D2782C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X80134 Genomic DNA. Translation: CAA56433.1.
    PIRiS65858. S49345.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X80134 Genomic DNA. Translation: CAA56433.1 .
    PIRi S65858. S49345.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00705 .

    Family and domain databases

    Gene3Di 1.20.210.10. 1 hit.
    InterProi IPR000883. COX1.
    IPR023615. Cyt_c_Oxase_su1_BS.
    IPR023616. Cyt_c_Oxase_su1_dom.
    IPR004677. Cyt_c_oxidase_cbb3_su1.
    [Graphical view ]
    PANTHERi PTHR10422. PTHR10422. 1 hit.
    Pfami PF00115. COX1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81442. SSF81442. 1 hit.
    TIGRFAMsi TIGR00780. ccoN. 1 hit.
    PROSITEi PS50855. COX1. 1 hit.
    PS00077. COX1_CUB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The ccoNOQP gene cluster codes for a cb-type cytochrome oxidase that functions in aerobic respiration of Rhodobacter capsulatus."
      Thony-Meyer L., Beck C., Preisig O., Hennecke H.
      Mol. Microbiol. 14:705-716(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: DSM 938 / 37b4.

    Entry informationi

    Entry nameiCOX1_RHOCA
    AccessioniPrimary (citable) accession number: P98059
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3