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P98057

- COX14_BRADU

UniProt

P98057 - COX14_BRADU

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Protein

Probable cytochrome c oxidase subunit 1

Gene
blr2715
Organism
Bradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi105 – 1051Iron (low-spin heme axial ligand) By similarity
Metal bindingi283 – 2831Copper B By similarity
Metal bindingi287 – 2871Copper B By similarity
Metal bindingi332 – 3321Copper B By similarity
Metal bindingi333 – 3331Copper B By similarity
Metal bindingi418 – 4181Iron (high-spin heme axial ligand) By similarity
Metal bindingi420 – 4201Iron (low-spin heme axial ligand) By similarity

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
  4. oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor Source: InterPro

GO - Biological processi

  1. aerobic respiration Source: InterPro
  2. oxidative phosphorylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciBJAP224911:GJEJ-2739-MONOMER.
UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide I
Fourth terminal oxidase
Gene namesi
Ordered Locus Names:blr2715
OrganismiBradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Taxonomic identifieri224911 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeBradyrhizobium
ProteomesiUP000002526: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei16 – 3621Helical; Reviewed predictionAdd
BLAST
Transmembranei57 – 7721Helical; Reviewed predictionAdd
BLAST
Transmembranei108 – 12821Helical; Reviewed predictionAdd
BLAST
Transmembranei142 – 16221Helical; Reviewed predictionAdd
BLAST
Transmembranei192 – 21221Helical; Reviewed predictionAdd
BLAST
Transmembranei234 – 25421Helical; Reviewed predictionAdd
BLAST
Transmembranei277 – 29721Helical; Reviewed predictionAdd
BLAST
Transmembranei315 – 33521Helical; Reviewed predictionAdd
BLAST
Transmembranei346 – 36621Helical; Reviewed predictionAdd
BLAST
Transmembranei380 – 40021Helical; Reviewed predictionAdd
BLAST
Transmembranei413 – 43321Helical; Reviewed predictionAdd
BLAST
Transmembranei456 – 47621Helical; Reviewed predictionAdd
BLAST
Transmembranei493 – 51321Helical; Reviewed predictionAdd
BLAST
Transmembranei591 – 61121Helical; Reviewed predictionAdd
BLAST
Transmembranei612 – 63221Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 666666Probable cytochrome c oxidase subunit 1PRO_0000183471Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki283 ↔ 2871'-histidyl-3'-tyrosine (His-Tyr) By similarity

Interactioni

Protein-protein interaction databases

STRINGi224911.blr2715.

Structurei

3D structure databases

ProteinModelPortaliP98057.
SMRiP98057. Positions 52-551.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0843.
HOGENOMiHOG000085275.
KOiK02298.
OrthoDBiEOG6B35XR.
PhylomeDBiP98057.

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR014207. Cyt_c_ubiqinol_oxidase_su1.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
TIGRFAMsiTIGR02843. CyoB. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P98057-1 [UniParc]FASTAAdd to Basket

« Hide

MLGKLDWSAI PFDQPIPLIA GAVVLVAILA VLVWVVVKGH LPYLWHEWIT    50
SVDHKRIGVM YILLASIMLL RGGSDAIMMR IQQAVAYQSQ GYLPPEHYNQ 100
IFSAHGTIMI FFVAMPFVIG LMNLVVPLQL GVRDVAFPTL NSVGFWLTAT 150
GALLVNLSLV IGEFARTGWL AFPPLSGLSY SPGVGVDYYA WSLQISGVGT 200
LVAGINLVTT VLKLRTKGMN YLRMPMFCWT TLASNLLIVA AFPILTATLA 250
MLLLDRYLGF HFFTNEAGGN VMMFMNLIWA WGHPEVYILV LPAFGIFSEV 300
VSTFSGKALF GYRSMVLATM AICVISFMVW LHHFFTMGAG PDVNAIFGIA 350
SMIIAVPTGV KIYNWLFTMY GGRIRFATPM LWAVGFMVTF IIGGLTGVLV 400
AVPPADFMLH NSMFLVAHFH NVIIGGVLFG AFAGFEYWFP KAFGFRLDER 450
WGKLAFWFTF LGFYVTFMPL YIAGMLGMTR RLQHYDVAAW RPWMLVAAAG 500
MAVLTIGVIC QIMQLVVSIR NREALRDRTG DPWDGRSLEW ATSSPPPVFN 550
FAFSPDVRGE DAYWDMKTHA RQQSFEHDAP EYHDIEMPRN SPTGFICAFF 600
ATIMGFALIW HIWWMVILGG IGAFATFVVF AWRDHDEYVI PADEVARIDR 650
INLEERRSLV SMAGVV 666
Length:666
Mass (Da):74,469
Last modified:February 28, 2003 - v2
Checksum:iF04F4870CD039861
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti204 – 2041G → D in AAA26210. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L25841 Genomic DNA. Translation: AAA26210.1.
BA000040 Genomic DNA. Translation: BAC47980.1.
RefSeqiNP_769355.1. NC_004463.1.

Genome annotation databases

EnsemblBacteriaiBAC47980; BAC47980; BAC47980.
GeneIDi1054159.
KEGGibja:blr2715.
PATRICi21188868. VBIBraJap65052_2692.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L25841 Genomic DNA. Translation: AAA26210.1 .
BA000040 Genomic DNA. Translation: BAC47980.1 .
RefSeqi NP_769355.1. NC_004463.1.

3D structure databases

ProteinModelPortali P98057.
SMRi P98057. Positions 52-551.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224911.blr2715.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAC47980 ; BAC47980 ; BAC47980 .
GeneIDi 1054159.
KEGGi bja:blr2715.
PATRICi 21188868. VBIBraJap65052_2692.

Phylogenomic databases

eggNOGi COG0843.
HOGENOMi HOG000085275.
KOi K02298.
OrthoDBi EOG6B35XR.
PhylomeDBi P98057.

Enzyme and pathway databases

UniPathwayi UPA00705 .
BioCyci BJAP224911:GJEJ-2739-MONOMER.

Family and domain databases

Gene3Di 1.20.210.10. 1 hit.
InterProi IPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR014207. Cyt_c_ubiqinol_oxidase_su1.
[Graphical view ]
PANTHERi PTHR10422. PTHR10422. 1 hit.
Pfami PF00115. COX1. 1 hit.
[Graphical view ]
PRINTSi PR01165. CYCOXIDASEI.
SUPFAMi SSF81442. SSF81442. 1 hit.
TIGRFAMsi TIGR02843. CyoB. 1 hit.
PROSITEi PS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genetic evidence for a fourth terminal oxidase in Bradyrhizobium japonicum."
    Surpin M.A., Moshiri F., Murphy A.M., Maier R.J.
    Gene 143:73-77(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110.

Entry informationi

Entry nameiCOX14_BRADU
AccessioniPrimary (citable) accession number: P98057
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 28, 2003
Last modified: September 3, 2014
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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