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P98057 (COX14_BRADU) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable cytochrome c oxidase subunit 1

EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide I
Fourth terminal oxidase
Gene names
Ordered Locus Names:blr2715
OrganismBradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110) [Reference proteome] [HAMAP]
Taxonomic identifier224911 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeBradyrhizobium

Protein attributes

Sequence length666 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathway

Energy metabolism; oxidative phosphorylation.

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 666666Probable cytochrome c oxidase subunit 1
PRO_0000183471

Regions

Transmembrane16 – 3621Helical; Potential
Transmembrane57 – 7721Helical; Potential
Transmembrane108 – 12821Helical; Potential
Transmembrane142 – 16221Helical; Potential
Transmembrane192 – 21221Helical; Potential
Transmembrane234 – 25421Helical; Potential
Transmembrane277 – 29721Helical; Potential
Transmembrane315 – 33521Helical; Potential
Transmembrane346 – 36621Helical; Potential
Transmembrane380 – 40021Helical; Potential
Transmembrane413 – 43321Helical; Potential
Transmembrane456 – 47621Helical; Potential
Transmembrane493 – 51321Helical; Potential
Transmembrane591 – 61121Helical; Potential
Transmembrane612 – 63221Helical; Potential

Sites

Metal binding1051Iron (low-spin heme axial ligand) By similarity
Metal binding2831Copper B By similarity
Metal binding2871Copper B By similarity
Metal binding3321Copper B By similarity
Metal binding3331Copper B By similarity
Metal binding4181Iron (high-spin heme axial ligand) By similarity
Metal binding4201Iron (low-spin heme axial ligand) By similarity

Amino acid modifications

Cross-link283 ↔ 2871'-histidyl-3'-tyrosine (His-Tyr) By similarity

Experimental info

Sequence conflict2041G → D in AAA26210. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P98057 [UniParc].

Last modified February 28, 2003. Version 2.
Checksum: F04F4870CD039861

FASTA66674,469
        10         20         30         40         50         60 
MLGKLDWSAI PFDQPIPLIA GAVVLVAILA VLVWVVVKGH LPYLWHEWIT SVDHKRIGVM 

        70         80         90        100        110        120 
YILLASIMLL RGGSDAIMMR IQQAVAYQSQ GYLPPEHYNQ IFSAHGTIMI FFVAMPFVIG 

       130        140        150        160        170        180 
LMNLVVPLQL GVRDVAFPTL NSVGFWLTAT GALLVNLSLV IGEFARTGWL AFPPLSGLSY 

       190        200        210        220        230        240 
SPGVGVDYYA WSLQISGVGT LVAGINLVTT VLKLRTKGMN YLRMPMFCWT TLASNLLIVA 

       250        260        270        280        290        300 
AFPILTATLA MLLLDRYLGF HFFTNEAGGN VMMFMNLIWA WGHPEVYILV LPAFGIFSEV 

       310        320        330        340        350        360 
VSTFSGKALF GYRSMVLATM AICVISFMVW LHHFFTMGAG PDVNAIFGIA SMIIAVPTGV 

       370        380        390        400        410        420 
KIYNWLFTMY GGRIRFATPM LWAVGFMVTF IIGGLTGVLV AVPPADFMLH NSMFLVAHFH 

       430        440        450        460        470        480 
NVIIGGVLFG AFAGFEYWFP KAFGFRLDER WGKLAFWFTF LGFYVTFMPL YIAGMLGMTR 

       490        500        510        520        530        540 
RLQHYDVAAW RPWMLVAAAG MAVLTIGVIC QIMQLVVSIR NREALRDRTG DPWDGRSLEW 

       550        560        570        580        590        600 
ATSSPPPVFN FAFSPDVRGE DAYWDMKTHA RQQSFEHDAP EYHDIEMPRN SPTGFICAFF 

       610        620        630        640        650        660 
ATIMGFALIW HIWWMVILGG IGAFATFVVF AWRDHDEYVI PADEVARIDR INLEERRSLV 


SMAGVV 

« Hide

References

« Hide 'large scale' references
[1]"Genetic evidence for a fourth terminal oxidase in Bradyrhizobium japonicum."
Surpin M.A., Moshiri F., Murphy A.M., Maier R.J.
Gene 143:73-77(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Complete genomic sequence of nitrogen-fixing symbiotic bacterium Bradyrhizobium japonicum USDA110."
Kaneko T., Nakamura Y., Sato S., Minamisawa K., Uchiumi T., Sasamoto S., Watanabe A., Idesawa K., Iriguchi M., Kawashima K., Kohara M., Matsumoto M., Shimpo S., Tsuruoka H., Wada T., Yamada M., Tabata S.
DNA Res. 9:189-197(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L25841 Genomic DNA. Translation: AAA26210.1.
BA000040 Genomic DNA. Translation: BAC47980.1.
RefSeqNP_769355.1. NC_004463.1.

3D structure databases

ProteinModelPortalP98057.
SMRP98057. Positions 52-551.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING224911.blr2715.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAC47980; BAC47980; BAC47980.
GeneID1054159.
KEGGbja:blr2715.
PATRIC21188868. VBIBraJap65052_2692.

Phylogenomic databases

eggNOGCOG0843.
HOGENOMHOG000085275.
KOK02298.
OrthoDBEOG6B35XR.
PhylomeDBP98057.

Enzyme and pathway databases

BioCycBJAP224911:GJEJ-2739-MONOMER.
UniPathwayUPA00705.

Family and domain databases

Gene3D1.20.210.10. 1 hit.
InterProIPR000883. Cyt_c_Oxase_su1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR014207. Cyt_c_ubiqinol_oxidase_su1.
[Graphical view]
PANTHERPTHR10422. PTHR10422. 1 hit.
PfamPF00115. COX1. 1 hit.
[Graphical view]
PRINTSPR01165. CYCOXIDASEI.
SUPFAMSSF81442. SSF81442. 1 hit.
TIGRFAMsTIGR02843. CyoB. 1 hit.
PROSITEPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX14_BRADU
AccessionPrimary (citable) accession number: P98057
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 28, 2003
Last modified: July 9, 2014
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways