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P98057

- COX14_BRADU

UniProt

P98057 - COX14_BRADU

Protein

Probable cytochrome c oxidase subunit 1

Gene

blr2715

Organism
Bradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 2 (28 Feb 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi105 – 1051Iron (low-spin heme axial ligand)By similarity
    Metal bindingi283 – 2831Copper BBy similarity
    Metal bindingi287 – 2871Copper BBy similarity
    Metal bindingi332 – 3321Copper BBy similarity
    Metal bindingi333 – 3331Copper BBy similarity
    Metal bindingi418 – 4181Iron (high-spin heme axial ligand)By similarity
    Metal bindingi420 – 4201Iron (low-spin heme axial ligand)By similarity

    GO - Molecular functioni

    1. cytochrome-c oxidase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro
    4. oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor Source: InterPro

    GO - Biological processi

    1. aerobic respiration Source: InterPro
    2. oxidative phosphorylation Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    Copper, Heme, Iron, Metal-binding

    Enzyme and pathway databases

    BioCyciBJAP224911:GJEJ-2739-MONOMER.
    UniPathwayiUPA00705.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable cytochrome c oxidase subunit 1 (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome c oxidase polypeptide I
    Fourth terminal oxidase
    Gene namesi
    Ordered Locus Names:blr2715
    OrganismiBradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
    Taxonomic identifieri224911 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeBradyrhizobium
    ProteomesiUP000002526: Chromosome

    Subcellular locationi

    Cell membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell
    3. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 666666Probable cytochrome c oxidase subunit 1PRO_0000183471Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Cross-linki283 ↔ 2871'-histidyl-3'-tyrosine (His-Tyr)By similarity

    Interactioni

    Protein-protein interaction databases

    STRINGi224911.blr2715.

    Structurei

    3D structure databases

    ProteinModelPortaliP98057.
    SMRiP98057. Positions 52-551.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei16 – 3621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei57 – 7721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei108 – 12821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei142 – 16221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei192 – 21221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei234 – 25421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei277 – 29721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei315 – 33521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei346 – 36621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei380 – 40021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei413 – 43321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei456 – 47621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei493 – 51321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei591 – 61121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei612 – 63221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0843.
    HOGENOMiHOG000085275.
    KOiK02298.
    OrthoDBiEOG6B35XR.
    PhylomeDBiP98057.

    Family and domain databases

    Gene3Di1.20.210.10. 1 hit.
    InterProiIPR000883. COX1.
    IPR023615. Cyt_c_Oxase_su1_BS.
    IPR023616. Cyt_c_Oxase_su1_dom.
    IPR014207. Cyt_c_ubiqinol_oxidase_su1.
    [Graphical view]
    PANTHERiPTHR10422. PTHR10422. 1 hit.
    PfamiPF00115. COX1. 1 hit.
    [Graphical view]
    PRINTSiPR01165. CYCOXIDASEI.
    SUPFAMiSSF81442. SSF81442. 1 hit.
    TIGRFAMsiTIGR02843. CyoB. 1 hit.
    PROSITEiPS50855. COX1. 1 hit.
    PS00077. COX1_CUB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P98057-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLGKLDWSAI PFDQPIPLIA GAVVLVAILA VLVWVVVKGH LPYLWHEWIT    50
    SVDHKRIGVM YILLASIMLL RGGSDAIMMR IQQAVAYQSQ GYLPPEHYNQ 100
    IFSAHGTIMI FFVAMPFVIG LMNLVVPLQL GVRDVAFPTL NSVGFWLTAT 150
    GALLVNLSLV IGEFARTGWL AFPPLSGLSY SPGVGVDYYA WSLQISGVGT 200
    LVAGINLVTT VLKLRTKGMN YLRMPMFCWT TLASNLLIVA AFPILTATLA 250
    MLLLDRYLGF HFFTNEAGGN VMMFMNLIWA WGHPEVYILV LPAFGIFSEV 300
    VSTFSGKALF GYRSMVLATM AICVISFMVW LHHFFTMGAG PDVNAIFGIA 350
    SMIIAVPTGV KIYNWLFTMY GGRIRFATPM LWAVGFMVTF IIGGLTGVLV 400
    AVPPADFMLH NSMFLVAHFH NVIIGGVLFG AFAGFEYWFP KAFGFRLDER 450
    WGKLAFWFTF LGFYVTFMPL YIAGMLGMTR RLQHYDVAAW RPWMLVAAAG 500
    MAVLTIGVIC QIMQLVVSIR NREALRDRTG DPWDGRSLEW ATSSPPPVFN 550
    FAFSPDVRGE DAYWDMKTHA RQQSFEHDAP EYHDIEMPRN SPTGFICAFF 600
    ATIMGFALIW HIWWMVILGG IGAFATFVVF AWRDHDEYVI PADEVARIDR 650
    INLEERRSLV SMAGVV 666
    Length:666
    Mass (Da):74,469
    Last modified:February 28, 2003 - v2
    Checksum:iF04F4870CD039861
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti204 – 2041G → D in AAA26210. (PubMed:8200541)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L25841 Genomic DNA. Translation: AAA26210.1.
    BA000040 Genomic DNA. Translation: BAC47980.1.
    RefSeqiNP_769355.1. NC_004463.1.

    Genome annotation databases

    EnsemblBacteriaiBAC47980; BAC47980; BAC47980.
    GeneIDi1054159.
    KEGGibja:blr2715.
    PATRICi21188868. VBIBraJap65052_2692.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L25841 Genomic DNA. Translation: AAA26210.1 .
    BA000040 Genomic DNA. Translation: BAC47980.1 .
    RefSeqi NP_769355.1. NC_004463.1.

    3D structure databases

    ProteinModelPortali P98057.
    SMRi P98057. Positions 52-551.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 224911.blr2715.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAC47980 ; BAC47980 ; BAC47980 .
    GeneIDi 1054159.
    KEGGi bja:blr2715.
    PATRICi 21188868. VBIBraJap65052_2692.

    Phylogenomic databases

    eggNOGi COG0843.
    HOGENOMi HOG000085275.
    KOi K02298.
    OrthoDBi EOG6B35XR.
    PhylomeDBi P98057.

    Enzyme and pathway databases

    UniPathwayi UPA00705 .
    BioCyci BJAP224911:GJEJ-2739-MONOMER.

    Family and domain databases

    Gene3Di 1.20.210.10. 1 hit.
    InterProi IPR000883. COX1.
    IPR023615. Cyt_c_Oxase_su1_BS.
    IPR023616. Cyt_c_Oxase_su1_dom.
    IPR014207. Cyt_c_ubiqinol_oxidase_su1.
    [Graphical view ]
    PANTHERi PTHR10422. PTHR10422. 1 hit.
    Pfami PF00115. COX1. 1 hit.
    [Graphical view ]
    PRINTSi PR01165. CYCOXIDASEI.
    SUPFAMi SSF81442. SSF81442. 1 hit.
    TIGRFAMsi TIGR02843. CyoB. 1 hit.
    PROSITEi PS50855. COX1. 1 hit.
    PS00077. COX1_CUB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genetic evidence for a fourth terminal oxidase in Bradyrhizobium japonicum."
      Surpin M.A., Moshiri F., Murphy A.M., Maier R.J.
      Gene 143:73-77(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110.

    Entry informationi

    Entry nameiCOX14_BRADU
    AccessioniPrimary (citable) accession number: P98057
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 28, 2003
    Last modified: October 1, 2014
    This is version 100 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3