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Protein

Probable cytochrome c oxidase subunit 1

Gene

blr2715

Organism
Bradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi: oxidative phosphorylation

This protein is involved in the pathway oxidative phosphorylation, which is part of Energy metabolism.
View all proteins of this organism that are known to be involved in the pathway oxidative phosphorylation and in Energy metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi105Iron (low-spin heme axial ligand)By similarity1
Metal bindingi283Copper BBy similarity1
Metal bindingi287Copper BBy similarity1
Metal bindingi332Copper BBy similarity1
Metal bindingi333Copper BBy similarity1
Metal bindingi418Iron (high-spin heme axial ligand)By similarity1
Metal bindingi420Iron (low-spin heme axial ligand)By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide I
Fourth terminal oxidase
Gene namesi
Ordered Locus Names:blr2715
OrganismiBradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Taxonomic identifieri224911 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeBradyrhizobium
Proteomesi
  • UP000002526 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei16 – 36HelicalSequence analysisAdd BLAST21
Transmembranei57 – 77HelicalSequence analysisAdd BLAST21
Transmembranei108 – 128HelicalSequence analysisAdd BLAST21
Transmembranei142 – 162HelicalSequence analysisAdd BLAST21
Transmembranei192 – 212HelicalSequence analysisAdd BLAST21
Transmembranei234 – 254HelicalSequence analysisAdd BLAST21
Transmembranei277 – 297HelicalSequence analysisAdd BLAST21
Transmembranei315 – 335HelicalSequence analysisAdd BLAST21
Transmembranei346 – 366HelicalSequence analysisAdd BLAST21
Transmembranei380 – 400HelicalSequence analysisAdd BLAST21
Transmembranei413 – 433HelicalSequence analysisAdd BLAST21
Transmembranei456 – 476HelicalSequence analysisAdd BLAST21
Transmembranei493 – 513HelicalSequence analysisAdd BLAST21
Transmembranei591 – 611HelicalSequence analysisAdd BLAST21
Transmembranei612 – 632HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001834711 – 666Probable cytochrome c oxidase subunit 1Add BLAST666

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki283 ↔ 2871'-histidyl-3'-tyrosine (His-Tyr)By similarity

Interactioni

Protein-protein interaction databases

STRINGi224911.blr2715.

Structurei

3D structure databases

ProteinModelPortaliP98057.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105BZ9. Bacteria.
COG0843. LUCA.
HOGENOMiHOG000085275.
InParanoidiP98057.
KOiK02298.
OMAiPPEHYNQ.
OrthoDBiPOG091H042R.
PhylomeDBiP98057.

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023616. Cyt_c_oxase-like_su1_dom.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR014207. Cyt_c_ubiqinol_oxidase_su1.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
TIGRFAMsiTIGR02843. CyoB. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P98057-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGKLDWSAI PFDQPIPLIA GAVVLVAILA VLVWVVVKGH LPYLWHEWIT
60 70 80 90 100
SVDHKRIGVM YILLASIMLL RGGSDAIMMR IQQAVAYQSQ GYLPPEHYNQ
110 120 130 140 150
IFSAHGTIMI FFVAMPFVIG LMNLVVPLQL GVRDVAFPTL NSVGFWLTAT
160 170 180 190 200
GALLVNLSLV IGEFARTGWL AFPPLSGLSY SPGVGVDYYA WSLQISGVGT
210 220 230 240 250
LVAGINLVTT VLKLRTKGMN YLRMPMFCWT TLASNLLIVA AFPILTATLA
260 270 280 290 300
MLLLDRYLGF HFFTNEAGGN VMMFMNLIWA WGHPEVYILV LPAFGIFSEV
310 320 330 340 350
VSTFSGKALF GYRSMVLATM AICVISFMVW LHHFFTMGAG PDVNAIFGIA
360 370 380 390 400
SMIIAVPTGV KIYNWLFTMY GGRIRFATPM LWAVGFMVTF IIGGLTGVLV
410 420 430 440 450
AVPPADFMLH NSMFLVAHFH NVIIGGVLFG AFAGFEYWFP KAFGFRLDER
460 470 480 490 500
WGKLAFWFTF LGFYVTFMPL YIAGMLGMTR RLQHYDVAAW RPWMLVAAAG
510 520 530 540 550
MAVLTIGVIC QIMQLVVSIR NREALRDRTG DPWDGRSLEW ATSSPPPVFN
560 570 580 590 600
FAFSPDVRGE DAYWDMKTHA RQQSFEHDAP EYHDIEMPRN SPTGFICAFF
610 620 630 640 650
ATIMGFALIW HIWWMVILGG IGAFATFVVF AWRDHDEYVI PADEVARIDR
660
INLEERRSLV SMAGVV
Length:666
Mass (Da):74,469
Last modified:February 28, 2003 - v2
Checksum:iF04F4870CD039861
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti204G → D in AAA26210 (PubMed:8200541).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L25841 Genomic DNA. Translation: AAA26210.1.
BA000040 Genomic DNA. Translation: BAC47980.1.
RefSeqiNP_769355.1. NC_004463.1.
WP_011085500.1. NZ_CP011360.1.

Genome annotation databases

EnsemblBacteriaiBAC47980; BAC47980; BAC47980.
GeneIDi1054159.
KEGGibja:blr2715.
PATRICi21188868. VBIBraJap65052_2692.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L25841 Genomic DNA. Translation: AAA26210.1.
BA000040 Genomic DNA. Translation: BAC47980.1.
RefSeqiNP_769355.1. NC_004463.1.
WP_011085500.1. NZ_CP011360.1.

3D structure databases

ProteinModelPortaliP98057.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224911.blr2715.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAC47980; BAC47980; BAC47980.
GeneIDi1054159.
KEGGibja:blr2715.
PATRICi21188868. VBIBraJap65052_2692.

Phylogenomic databases

eggNOGiENOG4105BZ9. Bacteria.
COG0843. LUCA.
HOGENOMiHOG000085275.
InParanoidiP98057.
KOiK02298.
OMAiPPEHYNQ.
OrthoDBiPOG091H042R.
PhylomeDBiP98057.

Enzyme and pathway databases

UniPathwayiUPA00705.

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023616. Cyt_c_oxase-like_su1_dom.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR014207. Cyt_c_ubiqinol_oxidase_su1.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
TIGRFAMsiTIGR02843. CyoB. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCOX14_BRADU
AccessioniPrimary (citable) accession number: P98057
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 28, 2003
Last modified: November 30, 2016
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.