Probable cytochrome c oxidase subunit 1 - Bradyrhizobium japonicum

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Reviewed, UniProtKB/Swiss-Prot P98057 (COX14_BRAJA)

Last modified November 3, 2009. Version 63. History...

Clusters with 100%, 90%, 50% identity |

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
    Probable cytochrome c oxidase subunit 1
    EC=1.9.3.1
Alternative name(s):
    Cytochrome c oxidase polypeptide I
    Fourth terminal oxidase

Gene names

Ordered Locus Names:

blr2715

Organism

Bradyrhizobium japonicum [Complete proteome] [HAMAP]

Taxonomic identifier

375 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bradyrhizobiaceae › Bradyrhizobium

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Protein attributes

Sequence length	666 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

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General annotation (Comments)

Catalytic activity	4 ferrocytochrome c + O₂ + 4 H⁺ = 4 ferricytochrome c + 2 H₂O.
Pathway	Energy metabolism; oxidative phosphorylation.
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the heme-copper respiratory oxidase family.

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Ontologies

Keywords
Biological process	Electron transport Respiratory chain Transport
Cellular component	Cell membrane Membrane
Domain	Transmembrane
Ligand	Copper Heme Iron Metal-binding
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aerobic respiration Inferred from electronic annotation. Source: InterPro electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW respiratory chain Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	copper ion binding Inferred from electronic annotation. Source: UniProtKB-KW cytochrome-c oxidase activity Inferred from electronic annotation. Source: EC electron carrier activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: InterPro oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 666

666

Probable cytochrome c oxidase subunit 1

PRO_0000183471

Regions

Transmembrane

16 – 36

Potential

Transmembrane

57 – 77

Potential

Transmembrane

108 – 128

Potential

Transmembrane

142 – 162

Potential

Transmembrane

192 – 212

Potential

Transmembrane

234 – 254

Potential

Transmembrane

277 – 297

Potential

Transmembrane

315 – 335

Potential

Transmembrane

346 – 366

Potential

Transmembrane

380 – 400

Potential

Transmembrane

413 – 433

Potential

Transmembrane

456 – 476

Potential

Transmembrane

493 – 513

Potential

Transmembrane

591 – 611

Potential

Transmembrane

612 – 632

Potential

Sites

Metal binding

105

Iron (low-spin heme axial ligand) By similarity

Metal binding

283

Copper B By similarity

Metal binding

287

Copper B By similarity

Metal binding

332

Copper B By similarity

Metal binding

333

Copper B By similarity

Metal binding

418

Iron (high-spin heme axial ligand) By similarity

Metal binding

420

Iron (low-spin heme axial ligand) By similarity

Amino acid modifications

Cross-link

283 ↔ 287

1'-histidyl-3'-tyrosine (His-Tyr) By similarity

Experimental info

Sequence conflict

204

G → D in AAA26210. Ref.1

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Sequences

Sequence

Length

Mass (Da)

Tools

P98057-1 [UniParc].

Last modified February 28, 2003. Version 2.
Checksum: F04F4870CD039861
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FASTA

666

74,469

        10         20         30         40         50         60 
MLGKLDWSAI PFDQPIPLIA GAVVLVAILA VLVWVVVKGH LPYLWHEWIT SVDHKRIGVM 

        70         80         90        100        110        120 
YILLASIMLL RGGSDAIMMR IQQAVAYQSQ GYLPPEHYNQ IFSAHGTIMI FFVAMPFVIG 

       130        140        150        160        170        180 
LMNLVVPLQL GVRDVAFPTL NSVGFWLTAT GALLVNLSLV IGEFARTGWL AFPPLSGLSY 

       190        200        210        220        230        240 
SPGVGVDYYA WSLQISGVGT LVAGINLVTT VLKLRTKGMN YLRMPMFCWT TLASNLLIVA 

       250        260        270        280        290        300 
AFPILTATLA MLLLDRYLGF HFFTNEAGGN VMMFMNLIWA WGHPEVYILV LPAFGIFSEV 

       310        320        330        340        350        360 
VSTFSGKALF GYRSMVLATM AICVISFMVW LHHFFTMGAG PDVNAIFGIA SMIIAVPTGV 

       370        380        390        400        410        420 
KIYNWLFTMY GGRIRFATPM LWAVGFMVTF IIGGLTGVLV AVPPADFMLH NSMFLVAHFH 

       430        440        450        460        470        480 
NVIIGGVLFG AFAGFEYWFP KAFGFRLDER WGKLAFWFTF LGFYVTFMPL YIAGMLGMTR 

       490        500        510        520        530        540 
RLQHYDVAAW RPWMLVAAAG MAVLTIGVIC QIMQLVVSIR NREALRDRTG DPWDGRSLEW 

       550        560        570        580        590        600 
ATSSPPPVFN FAFSPDVRGE DAYWDMKTHA RQQSFEHDAP EYHDIEMPRN SPTGFICAFF 

       610        620        630        640        650        660 
ATIMGFALIW HIWWMVILGG IGAFATFVVF AWRDHDEYVI PADEVARIDR INLEERRSLV 


SMAGVV

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genetic evidence for a fourth terminal oxidase in Bradyrhizobium japonicum." Surpin M.A., Moshiri F., Murphy A.M., Maier R.J. Gene 143:73-77(1994) [PubMed: 8200541] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Complete genomic sequence of nitrogen-fixing symbiotic bacterium Bradyrhizobium japonicum USDA110." Kaneko T., Nakamura Y., Sato S., Minamisawa K., Uchiumi T., Sasamoto S., Watanabe A., Idesawa K., Iriguchi M., Kawashima K., Kohara M., Matsumoto M., Shimpo S., Tsuruoka H., Wada T., Yamada M., Tabata S. DNA Res. 9:189-197(2002) [PubMed: 12597275] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: USDA 110.

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Cross-references

Sequence databases
	L25841 Genomic DNA. Translation: AAA26210.1. BA000040 Genomic DNA. Translation: BAC47980.1.
RefSeq	NP_769355.1.
3D structure databases
HSSP	HSSP built from PDB template 1FFT based on UniProtKB P18401.
ModBase	Search...
Genome annotation databases
GeneID	1054159.
GenomeReviews	Gene locus blr2715 in contig BA000040_GR.
KEGG	bja:blr2715.
NMPDR	fig\|224911.1.peg.2715.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	P98057.
OMA	RFATPML.
Enzyme and pathway databases
BioCyc	BJAP224911:BLR2715-MON.
BRENDA	1.9.3.1. 280.
Family and domain databases
InterPro	IPR000883. Cyt_c_oxidase_su1. IPR014207. Cyt_c_ubiqinol_oxidase_su1. [Graphical view]
Gene3D	G3DSA:1.20.210.10. COX1. 1 hit.
PANTHER	PTHR10422. COX1. 1 hit.
Pfam	PF00115. COX1. 1 hit. [Graphical view]
PRINTS	PR01165. CYCOXIDASEI.
TIGRFAMs	TIGR02843. CyoB. 1 hit.
PROSITE	PS50855. COX1. 1 hit. PS00077. COX1_CUB. 1 hit. [Graphical view]
ProtoNet	Search...

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Entry information

Entry name

COX14_BRAJA

Accession

Primary (citable) accession number: P98057

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 28, 2003
Last modified:	November 3, 2009
This is version 63 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Amino acid modifications

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

Entry information

Relevant documents