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P98056 (FIXN_AZOC5) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 1 homolog
EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide I homolog
Gene names
Name:fixN
Ordered Locus Names:AZC_4523
OrganismAzorhizobium caulinodans (strain ATCC 43989 / DSM 5975 / ORS 571) [Complete proteome] [HAMAP]
Taxonomic identifier438753 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Xanthobacteraceae › Azorhizobium ›

Protein attributes

Sequence length551 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Co I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c or a quinol are transferred to the bimetallic center formed by a high-spin heme and copper B.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathway

Energy metabolism; oxidative phosphorylation.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 551551Cytochrome c oxidase subunit 1 homolog
PRO_0000183468

Regions

Transmembrane14 – 3421Helical; Potential
Transmembrane40 – 6021Helical; Potential
Transmembrane88 – 10821Helical; Potential
Transmembrane133 – 15321Helical; Potential
Transmembrane169 – 18921Helical; Potential
Transmembrane202 – 22221Helical; Potential
Transmembrane229 – 24921Helical; Potential
Transmembrane280 – 30021Helical; Potential
Transmembrane313 – 33321Helical; Potential
Transmembrane345 – 36521Helical; Potential
Transmembrane383 – 40321Helical; Potential
Transmembrane424 – 44421Helical; Potential
Transmembrane459 – 47921Helical; Potential
Transmembrane513 – 53321Helical; Potential

Sites

Metal binding1321Iron (low-spin heme axial ligand) By similarity
Metal binding2811Copper B By similarity
Metal binding3311Copper B By similarity
Metal binding3321Copper B By similarity
Metal binding4191Iron (high-spin heme axial ligand) By similarity
Metal binding4211Iron (low-spin heme axial ligand) By similarity

Sequences

Sequence LengthMass (Da)Tools
P98056 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: 0466F71CD04BFC4D

FASTA55161,843
        10         20         30         40         50         60 
MSIVQTPAKR MTGGELGLIL VFAALGFFSI VVAAKAYTPE YAFHAYLFAA ASIATVFVIG 

        70         80         90        100        110        120 
NRYMDRPAEL PPQTIDGKPN YNMAPVKVGT LLAVFWGIAG FLIGVIIALQ MAYPLFNFDL 

       130        140        150        160        170        180 
PWISFGRLRP LHTSAVIFAF GGNVLIATSF YVVQRTSHAR LAGYLAPWFV VLGYNFFIVI 

       190        200        210        220        230        240 
AGTGYLLGIT QGKEYAEPEW YADLWLTIVW VTYFLVFLGT VLKRKEPHIY VANWFYLAFI 

       250        260        270        280        290        300 
LTIAVLHLGN NAAIPVSVFS PKSYIVWSGV QDAMVQWWYG HNAVGFFLTA GFLALMYYFI 

       310        320        330        340        350        360 
PKRADKPVYS YRLSIVHFWA LIFLYIWAGP HHLHYTALPD WAQTLGMTFS IMLWMPSWGG 

       370        380        390        400        410        420 
MINGLMTLSG AWDKLRTDPI IRMMVVAVAF YGMATFEGPM MSVKSVNSLS HYTEWGIGHV 

       430        440        450        460        470        480 
HSGALGWVAY ISFGAIYCLI PWLWNKREMY SMKAIEWHFW VSTLGIVLYI CAMWVAGILQ 

       490        500        510        520        530        540 
GLMWRAYTAL GFLEYSFIET VEAMHPLYVI RAIGGILFLA GSLIMAWNVF MTITRAETVS 

       550 
QPSGAALAPA E

« Hide

References

« Hide 'large scale' references
[1]"Role of the fixGHI region of Azorhizobium caulinodans in free-living and symbiotic nitrogen fixation."
Mandon K., Kaminski P.A., Mougel C., Desnoues N., Elmerich C.
FEMS Microbiol. Lett. 114:185-189(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Functional analysis of the fixNOQP region of Azorhizobium caulinodans."
Mandon K., Kaminski P.A., Elmerich C.
J. Bacteriol. 176:2560-2568(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Complete genome sequence of the nitrogen-fixing bacterium Azorhizobium caulinodans ORS571."
Lee K.B., Backer P.D., Aono T., Liu C.T., Suzuki S., Suzuki T., Kaneko T., Yamada M., Tabata S., Kupfer D.M., Najar F.Z., Wiley G.B., Roe B., Binnewies T., Ussery D., Vereecke D., Gevers D., Holsters M., Oyaizu H.
Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 43989 / DSM 5975 / ORS 571.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X74410 Genomic DNA. Translation: CAA52429.1.
AP009384 Genomic DNA. Translation: BAF90521.1.
PIRA55582.
RefSeqYP_001527439.1. NC_009937.1.

3D structure databases

ProteinModelPortalP98056.
ModBaseSearch...

Protein-protein interaction databases

STRING438753.AZC_4523.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAF90521; BAF90521; AZC_4523.
GeneID5692366.
KEGGazc:AZC_4523.
PATRIC21025989. VBIAzoCau17976_4717.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG3278.
HOGENOMHOG000277908.
KOK00404.
OMADLNIQPW.
ProtClustDBPRK14488.

Enzyme and pathway databases

BioCycACAU438753:GJF3-4588-MONOMER.
UniPathwayUPA00705.

Family and domain databases

Gene3D1.20.210.10. 1 hit.
InterProIPR000883. Cyt_c_Oxase_su1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR004677. Cyt_c_oxidase_cbb3_su1.
[Graphical view]
PANTHERPTHR10422. PTHR10422. 1 hit.
PfamPF00115. COX1. 1 hit.
[Graphical view]
SUPFAMSSF81442. COX1. 1 hit.
TIGRFAMsTIGR00780. ccoN. 1 hit.
PROSITEPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFIXN_AZOC5
AccessionPrimary (citable) accession number: P98056
Secondary accession number(s): A8HZ09
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: May 1, 2013
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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