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Protein

Cytochrome c oxidase subunit 1 homolog

Gene

fixN

Organism
Azorhizobium caulinodans (strain ATCC 43989 / DSM 5975 / ORS 571)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Co I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c or a quinol are transferred to the bimetallic center formed by a high-spin heme and copper B.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi132 – 1321Iron (low-spin heme axial ligand)By similarity
Metal bindingi281 – 2811Copper BBy similarity
Metal bindingi331 – 3311Copper BBy similarity
Metal bindingi332 – 3321Copper BBy similarity
Metal bindingi419 – 4191Iron (high-spin heme axial ligand)By similarity
Metal bindingi421 – 4211Iron (low-spin heme axial ligand)By similarity

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro

GO - Biological processi

  1. aerobic respiration Source: InterPro
  2. oxidative phosphorylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciACAU438753:GJF3-4588-MONOMER.
UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 homolog (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide I homolog
Gene namesi
Name:fixN
Ordered Locus Names:AZC_4523
OrganismiAzorhizobium caulinodans (strain ATCC 43989 / DSM 5975 / ORS 571)
Taxonomic identifieri438753 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesXanthobacteraceaeAzorhizobium
ProteomesiUP000000270: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei14 – 3421HelicalSequence AnalysisAdd
BLAST
Transmembranei40 – 6021HelicalSequence AnalysisAdd
BLAST
Transmembranei88 – 10821HelicalSequence AnalysisAdd
BLAST
Transmembranei133 – 15321HelicalSequence AnalysisAdd
BLAST
Transmembranei169 – 18921HelicalSequence AnalysisAdd
BLAST
Transmembranei202 – 22221HelicalSequence AnalysisAdd
BLAST
Transmembranei229 – 24921HelicalSequence AnalysisAdd
BLAST
Transmembranei280 – 30021HelicalSequence AnalysisAdd
BLAST
Transmembranei313 – 33321HelicalSequence AnalysisAdd
BLAST
Transmembranei345 – 36521HelicalSequence AnalysisAdd
BLAST
Transmembranei383 – 40321HelicalSequence AnalysisAdd
BLAST
Transmembranei424 – 44421HelicalSequence AnalysisAdd
BLAST
Transmembranei459 – 47921HelicalSequence AnalysisAdd
BLAST
Transmembranei513 – 53321HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane respiratory chain complex IV Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 551551Cytochrome c oxidase subunit 1 homologPRO_0000183468Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi438753.AZC_4523.

Structurei

3D structure databases

ProteinModelPortaliP98056.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG3278.
HOGENOMiHOG000277908.
KOiK00404.
OMAiIVWVVYL.
OrthoDBiEOG6G7QZX.

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR004677. Cyt_c_oxidase_cbb3_su1.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
SUPFAMiSSF81442. SSF81442. 1 hit.
TIGRFAMsiTIGR00780. ccoN. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P98056-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSIVQTPAKR MTGGELGLIL VFAALGFFSI VVAAKAYTPE YAFHAYLFAA
60 70 80 90 100
ASIATVFVIG NRYMDRPAEL PPQTIDGKPN YNMAPVKVGT LLAVFWGIAG
110 120 130 140 150
FLIGVIIALQ MAYPLFNFDL PWISFGRLRP LHTSAVIFAF GGNVLIATSF
160 170 180 190 200
YVVQRTSHAR LAGYLAPWFV VLGYNFFIVI AGTGYLLGIT QGKEYAEPEW
210 220 230 240 250
YADLWLTIVW VTYFLVFLGT VLKRKEPHIY VANWFYLAFI LTIAVLHLGN
260 270 280 290 300
NAAIPVSVFS PKSYIVWSGV QDAMVQWWYG HNAVGFFLTA GFLALMYYFI
310 320 330 340 350
PKRADKPVYS YRLSIVHFWA LIFLYIWAGP HHLHYTALPD WAQTLGMTFS
360 370 380 390 400
IMLWMPSWGG MINGLMTLSG AWDKLRTDPI IRMMVVAVAF YGMATFEGPM
410 420 430 440 450
MSVKSVNSLS HYTEWGIGHV HSGALGWVAY ISFGAIYCLI PWLWNKREMY
460 470 480 490 500
SMKAIEWHFW VSTLGIVLYI CAMWVAGILQ GLMWRAYTAL GFLEYSFIET
510 520 530 540 550
VEAMHPLYVI RAIGGILFLA GSLIMAWNVF MTITRAETVS QPSGAALAPA

E
Length:551
Mass (Da):61,843
Last modified:February 1, 1996 - v1
Checksum:i0466F71CD04BFC4D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X74410 Genomic DNA. Translation: CAA52429.1.
AP009384 Genomic DNA. Translation: BAF90521.1.
PIRiA55582.
RefSeqiWP_012173042.1. NC_009937.1.
YP_001527439.1. NC_009937.1.

Genome annotation databases

EnsemblBacteriaiBAF90521; BAF90521; AZC_4523.
GeneIDi5692366.
KEGGiazc:AZC_4523.
PATRICi21025989. VBIAzoCau17976_4717.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X74410 Genomic DNA. Translation: CAA52429.1.
AP009384 Genomic DNA. Translation: BAF90521.1.
PIRiA55582.
RefSeqiWP_012173042.1. NC_009937.1.
YP_001527439.1. NC_009937.1.

3D structure databases

ProteinModelPortaliP98056.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi438753.AZC_4523.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAF90521; BAF90521; AZC_4523.
GeneIDi5692366.
KEGGiazc:AZC_4523.
PATRICi21025989. VBIAzoCau17976_4717.

Phylogenomic databases

eggNOGiCOG3278.
HOGENOMiHOG000277908.
KOiK00404.
OMAiIVWVVYL.
OrthoDBiEOG6G7QZX.

Enzyme and pathway databases

UniPathwayiUPA00705.
BioCyciACAU438753:GJF3-4588-MONOMER.

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR004677. Cyt_c_oxidase_cbb3_su1.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
SUPFAMiSSF81442. SSF81442. 1 hit.
TIGRFAMsiTIGR00780. ccoN. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Role of the fixGHI region of Azorhizobium caulinodans in free-living and symbiotic nitrogen fixation."
    Mandon K., Kaminski P.A., Mougel C., Desnoues N., Elmerich C.
    FEMS Microbiol. Lett. 114:185-189(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Functional analysis of the fixNOQP region of Azorhizobium caulinodans."
    Mandon K., Kaminski P.A., Elmerich C.
    J. Bacteriol. 176:2560-2568(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Complete genome sequence of the nitrogen-fixing bacterium Azorhizobium caulinodans ORS571."
    Lee K.B., Backer P.D., Aono T., Liu C.T., Suzuki S., Suzuki T., Kaneko T., Yamada M., Tabata S., Kupfer D.M., Najar F.Z., Wiley G.B., Roe B., Binnewies T., Ussery D., Vereecke D., Gevers D., Holsters M., Oyaizu H.
    Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43989 / DSM 5975 / ORS 571.

Entry informationi

Entry nameiFIXN_AZOC5
AccessioniPrimary (citable) accession number: P98056
Secondary accession number(s): A8HZ09
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: January 7, 2015
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.