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P98055

- FIXN_AGRT7

UniProt

P98055 - FIXN_AGRT7

Protein

Cytochrome c oxidase subunit 1 homolog

Gene

fixN

Organism
Agrobacterium tumefaciens (strain T37)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Co I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c or a quinol are transferred to the bimetallic center formed by a high-spin heme and copper B.

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi117 – 1171Iron (low-spin heme axial ligand)By similarity
    Metal bindingi266 – 2661Copper BBy similarity
    Metal bindingi316 – 3161Copper BBy similarity
    Metal bindingi317 – 3171Copper BBy similarity
    Metal bindingi404 – 4041Iron (high-spin heme axial ligand)By similarity
    Metal bindingi406 – 4061Iron (low-spin heme axial ligand)By similarity

    GO - Molecular functioni

    1. cytochrome-c oxidase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    GO - Biological processi

    1. aerobic respiration Source: InterPro
    2. oxidative phosphorylation Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    Copper, Heme, Iron, Metal-binding

    Enzyme and pathway databases

    BioCyciRETL1328306-WGS:GSTH-4453-MONOMER.
    RETL1328306-WGS:GSTH-5784-MONOMER.
    UniPathwayiUPA00705.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 1 homolog (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome c oxidase polypeptide I homolog
    Gene namesi
    Name:fixN
    OrganismiAgrobacterium tumefaciens (strain T37)
    Taxonomic identifieri176300 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupAgrobacteriumAgrobacterium tumefaciens complex

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane respiratory chain complex IV Source: InterPro

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 539539Cytochrome c oxidase subunit 1 homologPRO_0000183467Add
    BLAST

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei28 – 4821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei75 – 9521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei118 – 13821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei154 – 17421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei187 – 20721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei214 – 23421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei265 – 28521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei298 – 31821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei330 – 35021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei368 – 38821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei402 – 42221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei443 – 46321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei498 – 51821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Family and domain databases

    Gene3Di1.20.210.10. 1 hit.
    InterProiIPR000883. COX1.
    IPR023615. Cyt_c_Oxase_su1_BS.
    IPR023616. Cyt_c_Oxase_su1_dom.
    IPR004677. Cyt_c_oxidase_cbb3_su1.
    [Graphical view]
    PANTHERiPTHR10422. PTHR10422. 1 hit.
    PfamiPF00115. COX1. 1 hit.
    [Graphical view]
    SUPFAMiSSF81442. SSF81442. 1 hit.
    TIGRFAMsiTIGR00780. ccoN. 1 hit.
    PROSITEiPS50855. COX1. 1 hit.
    PS00077. COX1_CUB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P98055-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNYTLETADR ALGAFPALLG AAFAHDSLFA AHMWVLFFTL VVSTLLLLRR    50
    VSFLPPVAGP PCRRTEYFDE VVKYGVMATV FWGVVGFLVG VVVALQLAFP 100
    DLNIAPYFNF GRMRPLHTSA VIFAFGGNAL IATSFYVVQR TCRARLFGGN 150
    LGWFVFWGYN LFIIMAATGY LLGITQGREY AEPEWYVDLW LTIVWVAYLA 200
    TFLGTILTRK EPHISVANWF YLSFIVTIAM LHIVNNLAVP VSFLGVKSYS 250
    AFSGVQAALT QWWYGHNAVG FFLTAGFLGM MYYFIPKQVN RPVYSYRLSI 300
    IHFWALIFMY IWAGPHHLHY TALPDWAQTL GMVFSIMLWM PSWGGMINGL 350
    MTLSGAWDKI RTDPIVRMMV MAVAFYGMAT FEGPMMSIKA VNSLSHYTDW 400
    TIGHVHSGAL GWNGMITFGA IYYLTPKLWG RDRLYSLQLV NWHFWLATLG 450
    IVVYAAVMWV AGIQQALMWR EYDSQGFLVY SFAESVAALF PYYVMRALGG 500
    LMFLSGALIM AYNVTMTILG HQREEGASKG AAPSLQPAE 539
    Length:539
    Mass (Da):60,651
    Last modified:February 1, 1996 - v1
    Checksum:i6D99827DCA2E0C5F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z46239 Genomic DNA. Translation: CAA86308.1.
    PIRiS54758. S49495.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z46239 Genomic DNA. Translation: CAA86308.1 .
    PIRi S54758. S49495.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00705 .
    BioCyci RETL1328306-WGS:GSTH-4453-MONOMER.
    RETL1328306-WGS:GSTH-5784-MONOMER.

    Family and domain databases

    Gene3Di 1.20.210.10. 1 hit.
    InterProi IPR000883. COX1.
    IPR023615. Cyt_c_Oxase_su1_BS.
    IPR023616. Cyt_c_Oxase_su1_dom.
    IPR004677. Cyt_c_oxidase_cbb3_su1.
    [Graphical view ]
    PANTHERi PTHR10422. PTHR10422. 1 hit.
    Pfami PF00115. COX1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81442. SSF81442. 1 hit.
    TIGRFAMsi TIGR00780. ccoN. 1 hit.
    PROSITEi PS50855. COX1. 1 hit.
    PS00077. COX1_CUB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A homolog of the Rhizobium meliloti nitrogen fixation gene fixN is involved in the production of a microaerobically induced oxidase activity in the phytopathogenic bacterium Agrobacterium tumefaciens."
      Schlueter A., Rueberg S., Kraemer M., Weidner S., Priefer U.
      Mol. Gen. Genet. 247:206-215(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiFIXN_AGRT7
    AccessioniPrimary (citable) accession number: P98055
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3