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P98055 (FIXN_AGRT7) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 1 homolog
EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide I homolog
Gene names
Name:fixN
OrganismAgrobacterium tumefaciens (strain T37)
Taxonomic identifier176300 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Rhizobiaceae › Rhizobium/Agrobacterium group › Agrobacterium › Agrobacterium tumefaciens complex ›

Protein attributes

Sequence length539 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Co I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c or a quinol are transferred to the bimetallic center formed by a high-spin heme and copper B.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathway

Energy metabolism; oxidative phosphorylation.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 539539Cytochrome c oxidase subunit 1 homolog
PRO_0000183467

Regions

Transmembrane28 – 4821Helical; Potential
Transmembrane75 – 9521Helical; Potential
Transmembrane118 – 13821Helical; Potential
Transmembrane154 – 17421Helical; Potential
Transmembrane187 – 20721Helical; Potential
Transmembrane214 – 23421Helical; Potential
Transmembrane265 – 28521Helical; Potential
Transmembrane298 – 31821Helical; Potential
Transmembrane330 – 35021Helical; Potential
Transmembrane368 – 38821Helical; Potential
Transmembrane402 – 42221Helical; Potential
Transmembrane443 – 46321Helical; Potential
Transmembrane498 – 51821Helical; Potential

Sites

Metal binding1171Iron (low-spin heme axial ligand) By similarity
Metal binding2661Copper B By similarity
Metal binding3161Copper B By similarity
Metal binding3171Copper B By similarity
Metal binding4041Iron (high-spin heme axial ligand) By similarity
Metal binding4061Iron (low-spin heme axial ligand) By similarity

Sequences

Sequence LengthMass (Da)Tools
P98055 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: 6D99827DCA2E0C5F

FASTA53960,651
        10         20         30         40         50         60 
MNYTLETADR ALGAFPALLG AAFAHDSLFA AHMWVLFFTL VVSTLLLLRR VSFLPPVAGP 

        70         80         90        100        110        120 
PCRRTEYFDE VVKYGVMATV FWGVVGFLVG VVVALQLAFP DLNIAPYFNF GRMRPLHTSA 

       130        140        150        160        170        180 
VIFAFGGNAL IATSFYVVQR TCRARLFGGN LGWFVFWGYN LFIIMAATGY LLGITQGREY 

       190        200        210        220        230        240 
AEPEWYVDLW LTIVWVAYLA TFLGTILTRK EPHISVANWF YLSFIVTIAM LHIVNNLAVP 

       250        260        270        280        290        300 
VSFLGVKSYS AFSGVQAALT QWWYGHNAVG FFLTAGFLGM MYYFIPKQVN RPVYSYRLSI 

       310        320        330        340        350        360 
IHFWALIFMY IWAGPHHLHY TALPDWAQTL GMVFSIMLWM PSWGGMINGL MTLSGAWDKI 

       370        380        390        400        410        420 
RTDPIVRMMV MAVAFYGMAT FEGPMMSIKA VNSLSHYTDW TIGHVHSGAL GWNGMITFGA 

       430        440        450        460        470        480 
IYYLTPKLWG RDRLYSLQLV NWHFWLATLG IVVYAAVMWV AGIQQALMWR EYDSQGFLVY 

       490        500        510        520        530 
SFAESVAALF PYYVMRALGG LMFLSGALIM AYNVTMTILG HQREEGASKG AAPSLQPAE

« Hide

References

[1]"A homolog of the Rhizobium meliloti nitrogen fixation gene fixN is involved in the production of a microaerobically induced oxidase activity in the phytopathogenic bacterium Agrobacterium tumefaciens."
Schlueter A., Rueberg S., Kraemer M., Weidner S., Priefer U.
Mol. Gen. Genet. 247:206-215(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		Z46239 Genomic DNA. Translation: CAA86308.1.
PIRS49495. S54758.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00705.

Family and domain databases

Gene3D1.20.210.10. 1 hit.
InterProIPR000883. Cyt_c_Oxase_su1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR004677. Cyt_c_oxidase_cbb3_su1.
[Graphical view]
PANTHERPTHR10422. PTHR10422. 1 hit.
PfamPF00115. COX1. 1 hit.
[Graphical view]
SUPFAMSSF81442. COX1. 1 hit.
TIGRFAMsTIGR00780. ccoN. 1 hit.
PROSITEPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFIXN_AGRT7
AccessionPrimary (citable) accession number: P98055
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: April 3, 2013
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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