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P98055

- FIXN_AGRT7

UniProt

P98055 - FIXN_AGRT7

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Protein
Cytochrome c oxidase subunit 1 homolog
Gene
fixN
Organism
Agrobacterium tumefaciens (strain T37)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Co I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c or a quinol are transferred to the bimetallic center formed by a high-spin heme and copper B.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi117 – 1171Iron (low-spin heme axial ligand) By similarity
Metal bindingi266 – 2661Copper B By similarity
Metal bindingi316 – 3161Copper B By similarity
Metal bindingi317 – 3171Copper B By similarity
Metal bindingi404 – 4041Iron (high-spin heme axial ligand) By similarity
Metal bindingi406 – 4061Iron (low-spin heme axial ligand) By similarity

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. aerobic respiration Source: InterPro
  2. oxidative phosphorylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciRETL1328306-WGS:GSTH-4453-MONOMER.
RETL1328306-WGS:GSTH-5784-MONOMER.
UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 homolog (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide I homolog
Gene namesi
Name:fixN
OrganismiAgrobacterium tumefaciens (strain T37)
Taxonomic identifieri176300 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupAgrobacteriumAgrobacterium tumefaciens complex

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei28 – 4821Helical; Reviewed prediction
Add
BLAST
Transmembranei75 – 9521Helical; Reviewed prediction
Add
BLAST
Transmembranei118 – 13821Helical; Reviewed prediction
Add
BLAST
Transmembranei154 – 17421Helical; Reviewed prediction
Add
BLAST
Transmembranei187 – 20721Helical; Reviewed prediction
Add
BLAST
Transmembranei214 – 23421Helical; Reviewed prediction
Add
BLAST
Transmembranei265 – 28521Helical; Reviewed prediction
Add
BLAST
Transmembranei298 – 31821Helical; Reviewed prediction
Add
BLAST
Transmembranei330 – 35021Helical; Reviewed prediction
Add
BLAST
Transmembranei368 – 38821Helical; Reviewed prediction
Add
BLAST
Transmembranei402 – 42221Helical; Reviewed prediction
Add
BLAST
Transmembranei443 – 46321Helical; Reviewed prediction
Add
BLAST
Transmembranei498 – 51821Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane respiratory chain complex IV Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 539539Cytochrome c oxidase subunit 1 homolog
PRO_0000183467Add
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR004677. Cyt_c_oxidase_cbb3_su1.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
SUPFAMiSSF81442. SSF81442. 1 hit.
TIGRFAMsiTIGR00780. ccoN. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P98055-1 [UniParc]FASTAAdd to Basket

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MNYTLETADR ALGAFPALLG AAFAHDSLFA AHMWVLFFTL VVSTLLLLRR    50
VSFLPPVAGP PCRRTEYFDE VVKYGVMATV FWGVVGFLVG VVVALQLAFP 100
DLNIAPYFNF GRMRPLHTSA VIFAFGGNAL IATSFYVVQR TCRARLFGGN 150
LGWFVFWGYN LFIIMAATGY LLGITQGREY AEPEWYVDLW LTIVWVAYLA 200
TFLGTILTRK EPHISVANWF YLSFIVTIAM LHIVNNLAVP VSFLGVKSYS 250
AFSGVQAALT QWWYGHNAVG FFLTAGFLGM MYYFIPKQVN RPVYSYRLSI 300
IHFWALIFMY IWAGPHHLHY TALPDWAQTL GMVFSIMLWM PSWGGMINGL 350
MTLSGAWDKI RTDPIVRMMV MAVAFYGMAT FEGPMMSIKA VNSLSHYTDW 400
TIGHVHSGAL GWNGMITFGA IYYLTPKLWG RDRLYSLQLV NWHFWLATLG 450
IVVYAAVMWV AGIQQALMWR EYDSQGFLVY SFAESVAALF PYYVMRALGG 500
LMFLSGALIM AYNVTMTILG HQREEGASKG AAPSLQPAE 539
Length:539
Mass (Da):60,651
Last modified:February 1, 1996 - v1
Checksum:i6D99827DCA2E0C5F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z46239 Genomic DNA. Translation: CAA86308.1.
PIRiS54758. S49495.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z46239 Genomic DNA. Translation: CAA86308.1 .
PIRi S54758. S49495.

3D structure databases

ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00705 .
BioCyci RETL1328306-WGS:GSTH-4453-MONOMER.
RETL1328306-WGS:GSTH-5784-MONOMER.

Family and domain databases

Gene3Di 1.20.210.10. 1 hit.
InterProi IPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR004677. Cyt_c_oxidase_cbb3_su1.
[Graphical view ]
PANTHERi PTHR10422. PTHR10422. 1 hit.
Pfami PF00115. COX1. 1 hit.
[Graphical view ]
SUPFAMi SSF81442. SSF81442. 1 hit.
TIGRFAMsi TIGR00780. ccoN. 1 hit.
PROSITEi PS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A homolog of the Rhizobium meliloti nitrogen fixation gene fixN is involved in the production of a microaerobically induced oxidase activity in the phytopathogenic bacterium Agrobacterium tumefaciens."
    Schlueter A., Rueberg S., Kraemer M., Weidner S., Priefer U.
    Mol. Gen. Genet. 247:206-215(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiFIXN_AGRT7
AccessioniPrimary (citable) accession number: P98055
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: September 3, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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