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P98054

- COX2_THEVL

UniProt

P98054 - COX2_THEVL

Protein

Cytochrome c oxidase subunit 2

Gene

ctaC

Organism
Thermosynechococcus vulcanus (Synechococcus vulcanus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    Cofactori

    Copper A.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi221 – 2211Copper ACurated
    Metal bindingi255 – 2551Copper ACurated
    Metal bindingi259 – 2591Copper ACurated
    Metal bindingi263 – 2631Copper ACurated

    GO - Molecular functioni

    1. copper ion binding Source: InterPro
    2. cytochrome-c oxidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. electron transport chain Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    Copper, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome aa3 subunit 2
    Cytochrome c oxidase polypeptide II
    Oxidase aa(3) subunit 2
    Gene namesi
    Name:ctaC
    OrganismiThermosynechococcus vulcanus (Synechococcus vulcanus)
    Taxonomic identifieri32053 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesThermosynechococcus

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell
    3. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 327304Cytochrome c oxidase subunit 2PRO_0000006064Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP98054.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei56 – 7823HelicalSequence AnalysisAdd
    BLAST
    Transmembranei96 – 11419HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Family and domain databases

    Gene3Di1.10.287.90. 1 hit.
    2.60.40.420. 2 hits.
    InterProiIPR001505. Copper_CuA.
    IPR008972. Cupredoxin.
    IPR002429. Cyt_c_oxidase_su2_C.
    IPR011759. Cyt_c_oxidase_su2_TM_dom.
    [Graphical view]
    PfamiPF00116. COX2. 1 hit.
    PF02790. COX2_TM. 1 hit.
    [Graphical view]
    SUPFAMiSSF49503. SSF49503. 1 hit.
    SSF81464. SSF81464. 1 hit.
    PROSITEiPS00078. COX2. 1 hit.
    PS50857. COX2_CUA. 1 hit.
    PS50999. COX2_TM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P98054-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEQIPASIWT LTAGVVVTLI SFWVGHHHGL LPEQASEQAP LVDNFFDIML    50
    TIGTALFLVV QGAIILFVIR YRRRAGEEGD GLPVEGNLPL EAFWTAIPAL 100
    IVIFLGIYSV DIFQRMGGLN PGDHAMHSMH APKSGMAVVA QAPSKTTSDA 150
    TALLAAAQPP EIGIGASPDV QGKAPDLVVD VAGMQYAWIF TYPDSGIVSG 200
    ELHIPVGKDV QLNLSARDVI HSFWVPQFRL KQDAIPGVPT TRFKATKVGT 250
    YPVVCAELCG GYHGAMRTQV IVHTPEDFET WRRQNQAIAT APVIPSLRDR 300
    HIHEMGVTAE LVAQVEAIAH DPSAEKL 327
    Length:327
    Mass (Da):35,356
    Last modified:October 1, 1996 - v1
    Checksum:i2C28F9C68D3B7A13
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D16254 Genomic DNA. Translation: BAA41040.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D16254 Genomic DNA. Translation: BAA41040.1 .

    3D structure databases

    ProteinModelPortali P98054.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 1.10.287.90. 1 hit.
    2.60.40.420. 2 hits.
    InterProi IPR001505. Copper_CuA.
    IPR008972. Cupredoxin.
    IPR002429. Cyt_c_oxidase_su2_C.
    IPR011759. Cyt_c_oxidase_su2_TM_dom.
    [Graphical view ]
    Pfami PF00116. COX2. 1 hit.
    PF02790. COX2_TM. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49503. SSF49503. 1 hit.
    SSF81464. SSF81464. 1 hit.
    PROSITEi PS00078. COX2. 1 hit.
    PS50857. COX2_CUA. 1 hit.
    PS50999. COX2_TM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The cytochrome C oxidase genes in blue-green algae and characteristics of the deduced protein sequence for subunit II of the thermophilic cyanobacterium Synechococcus vulcanus."
      Tano H., Sone N.
      Biochem. Biophys. Res. Commun. 181:437-442(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The genes in the thermophilic cyanobacterium Synechococcus vulcanus encoding cytochrome-c oxidase."
      Sone N., Tano H., Ishizuka M.
      Biochim. Biophys. Acta 1183:130-138(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiCOX2_THEVL
    AccessioniPrimary (citable) accession number: P98054
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3