P98054 (COX2_THEVL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome c oxidase subunit 2
EC=1.9.3.1

Alternative name(s):
Cytochrome aa3 subunit 2
Cytochrome c oxidase polypeptide II
Oxidase aa(3) subunit 2

Gene names

Name:

ctaC

Organism

Thermosynechococcus vulcanus (Synechococcus vulcanus)

Taxonomic identifier

32053 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Cyanobacteria › Oscillatoriophycideae › Chroococcales › Thermosynechococcus

Protein attributes

Sequence length	327 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).
Catalytic activity	4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.
Cofactor	Copper A.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the cytochrome c oxidase subunit 2 family.

Ontologies

Keywords
Biological process	Electron transport Respiratory chain Transport
Cellular component	Cell membrane Membrane
Domain	Signal Transmembrane Transmembrane helix
Ligand	Copper Metal-binding
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological_process	electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell respiratory chain Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	copper ion binding Inferred from electronic annotation. Source: InterPro cytochrome-c oxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 23	23	Potential
	Chain	24 – 327	304	Cytochrome c oxidase subunit 2		PRO_0000006064
Regions
	Transmembrane	56 – 78	23	Helical; Potential
	Transmembrane	96 – 114	19	Helical; Potential
Sites
	Metal binding	221	1	Copper A Probable
	Metal binding	255	1	Copper A Probable
	Metal binding	259	1	Copper A Probable
	Metal binding	263	1	Copper A Probable

Sequences

	Sequence		Length	Mass (Da)
	P98054 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 2C28F9C68D3B7A13	FASTA	327	35,356
	10 20 30 40 50 60 MEQIPASIWT LTAGVVVTLI SFWVGHHHGL LPEQASEQAP LVDNFFDIML TIGTALFLVV 70 80 90 100 110 120 QGAIILFVIR YRRRAGEEGD GLPVEGNLPL EAFWTAIPAL IVIFLGIYSV DIFQRMGGLN 130 140 150 160 170 180 PGDHAMHSMH APKSGMAVVA QAPSKTTSDA TALLAAAQPP EIGIGASPDV QGKAPDLVVD 190 200 210 220 230 240 VAGMQYAWIF TYPDSGIVSG ELHIPVGKDV QLNLSARDVI HSFWVPQFRL KQDAIPGVPT 250 260 270 280 290 300 TRFKATKVGT YPVVCAELCG GYHGAMRTQV IVHTPEDFET WRRQNQAIAT APVIPSLRDR 310 320 HIHEMGVTAE LVAQVEAIAH DPSAEKL

References

[1]	"The cytochrome C oxidase genes in blue-green algae and characteristics of the deduced protein sequence for subunit II of the thermophilic cyanobacterium Synechococcus vulcanus." Tano H., Sone N. Biochem. Biophys. Res. Commun. 181:437-442(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The genes in the thermophilic cyanobacterium Synechococcus vulcanus encoding cytochrome-c oxidase." Sone N., Tano H., Ishizuka M. Biochim. Biophys. Acta 1183:130-138(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	D16254 Genomic DNA. Translation: BAA41040.1.
3D structure databases
ProteinModelPortal	P98054.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	1.10.287.90. 1 hit. 2.60.40.420. 2 hits.
InterPro	IPR001505. Copper_CuA. IPR008972. Cupredoxin. IPR002429. Cyt_c_oxidase_su2_C. IPR011759. Cyt_c_oxidase_su2_TM_dom. [Graphical view]
Pfam	PF00116. COX2. 1 hit. PF02790. COX2_TM. 1 hit. [Graphical view]
SUPFAM	SSF49503. Cupredoxin. 1 hit. SSF81464. Cyt_c_oxidase_II-like_TM. 1 hit.
PROSITE	PS00078. COX2. 1 hit. PS50857. COX2_CUA. 1 hit. PS50999. COX2_TM. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

COX2_THEVL

Accession

Primary (citable) accession number: P98054

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	May 1, 2013
This is version 82 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program