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P98054 (COX2_THEVL) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 2

EC=1.9.3.1
Alternative name(s):
Cytochrome aa3 subunit 2
Cytochrome c oxidase polypeptide II
Oxidase aa(3) subunit 2
Gene names
Name:ctaC
OrganismThermosynechococcus vulcanus (Synechococcus vulcanus)
Taxonomic identifier32053 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesThermosynechococcus

Protein attributes

Sequence length327 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactor

Copper A.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 2 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Chain24 – 327304Cytochrome c oxidase subunit 2
PRO_0000006064

Regions

Transmembrane56 – 7823Helical; Potential
Transmembrane96 – 11419Helical; Potential

Sites

Metal binding2211Copper A Probable
Metal binding2551Copper A Probable
Metal binding2591Copper A Probable
Metal binding2631Copper A Probable

Sequences

Sequence LengthMass (Da)Tools
P98054 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 2C28F9C68D3B7A13

FASTA32735,356
        10         20         30         40         50         60 
MEQIPASIWT LTAGVVVTLI SFWVGHHHGL LPEQASEQAP LVDNFFDIML TIGTALFLVV 

        70         80         90        100        110        120 
QGAIILFVIR YRRRAGEEGD GLPVEGNLPL EAFWTAIPAL IVIFLGIYSV DIFQRMGGLN 

       130        140        150        160        170        180 
PGDHAMHSMH APKSGMAVVA QAPSKTTSDA TALLAAAQPP EIGIGASPDV QGKAPDLVVD 

       190        200        210        220        230        240 
VAGMQYAWIF TYPDSGIVSG ELHIPVGKDV QLNLSARDVI HSFWVPQFRL KQDAIPGVPT 

       250        260        270        280        290        300 
TRFKATKVGT YPVVCAELCG GYHGAMRTQV IVHTPEDFET WRRQNQAIAT APVIPSLRDR 

       310        320 
HIHEMGVTAE LVAQVEAIAH DPSAEKL 

« Hide

References

[1]"The cytochrome C oxidase genes in blue-green algae and characteristics of the deduced protein sequence for subunit II of the thermophilic cyanobacterium Synechococcus vulcanus."
Tano H., Sone N.
Biochem. Biophys. Res. Commun. 181:437-442(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The genes in the thermophilic cyanobacterium Synechococcus vulcanus encoding cytochrome-c oxidase."
Sone N., Tano H., Ishizuka M.
Biochim. Biophys. Acta 1183:130-138(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D16254 Genomic DNA. Translation: BAA41040.1.

3D structure databases

ProteinModelPortalP98054.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D1.10.287.90. 1 hit.
2.60.40.420. 2 hits.
InterProIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
PROSITEPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX2_THEVL
AccessionPrimary (citable) accession number: P98054
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 16, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families