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P98053

- COXM_BRADU

UniProt

P98053 - COXM_BRADU

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Protein

Alternative cytochrome c oxidase subunit 2

Gene

coxM

Organism
Bradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi190 – 1901Copper ACurated
Metal bindingi225 – 2251Copper ACurated
Metal bindingi229 – 2291Copper ACurated
Metal bindingi233 – 2331Copper ACurated

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. cytochrome-c oxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. electron transport chain Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciBJAP224911:GJEJ-3809-MONOMER.
RETL1328306-WGS:GSTH-2650-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Alternative cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Alternative cytochrome c oxidase polypeptide II
Cytochrome BB3 subunit 2
Oxidase BB(3) subunit 2
Gene namesi
Name:coxM
Ordered Locus Names:bll3785
OrganismiBradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Taxonomic identifieri224911 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeBradyrhizobium
ProteomesiUP000002526: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 277277Alternative cytochrome c oxidase subunit 2PRO_0000183724Add
BLAST

Expressioni

Developmental stagei

Bacteroid (nitrogen-fixing endosymbiont).

Interactioni

Protein-protein interaction databases

STRINGi224911.bll3785.

Structurei

3D structure databases

ProteinModelPortaliP98053.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4040PeriplasmicSequence AnalysisAdd
BLAST
Topological domaini62 – 8322CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini105 – 277173PeriplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei41 – 6121HelicalSequence AnalysisAdd
BLAST
Transmembranei84 – 10421HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1622.
HOGENOMiHOG000268576.
InParanoidiP98053.
KOiK02275.
OrthoDBiEOG68SVXT.
PhylomeDBiP98053.

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P98053-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAVALILLLI AIGSVLFHLF SPWWWTPIAT NWGYIDDTIN ITFWITGFVF
60 70 80 90 100
TAVILFMAYC VFRFHHKEGR QAAYNPENKK LEWWLSVGTG VGVAAMLAPG
110 120 130 140 150
LVVWHQFVTV PADATEVEIM GQQWQWSFRL PGKDGRLGTS DVRNISPENP
160 170 180 190 200
MGLNRDDPHG QDDVVIENGD LHLPIGKPVK VLLRSVDVLH DFYVPEFRAK
210 220 230 240 250
MDMVPGMVTY FWIRPIRTGT FDVLCAELCG AAHYQMRAKV IVEAESDYHA
260 270
WLEQQKTFAG LSGRNAVVRA KYNSGDD
Length:277
Mass (Da):31,327
Last modified:October 1, 1996 - v1
Checksum:iD262ADE2233D36E1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X68547 Genomic DNA. Translation: CAA48547.1.
BA000040 Genomic DNA. Translation: BAC49050.1.
PIRiB48364.
RefSeqiNP_770425.1. NC_004463.1.

Genome annotation databases

EnsemblBacteriaiBAC49050; BAC49050; BAC49050.
GeneIDi1053041.
KEGGibja:bll3785.
PATRICi21191037. VBIBraJap65052_3776.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X68547 Genomic DNA. Translation: CAA48547.1 .
BA000040 Genomic DNA. Translation: BAC49050.1 .
PIRi B48364.
RefSeqi NP_770425.1. NC_004463.1.

3D structure databases

ProteinModelPortali P98053.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224911.bll3785.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAC49050 ; BAC49050 ; BAC49050 .
GeneIDi 1053041.
KEGGi bja:bll3785.
PATRICi 21191037. VBIBraJap65052_3776.

Phylogenomic databases

eggNOGi COG1622.
HOGENOMi HOG000268576.
InParanoidi P98053.
KOi K02275.
OrthoDBi EOG68SVXT.
PhylomeDBi P98053.

Enzyme and pathway databases

BioCyci BJAP224911:GJEJ-3809-MONOMER.
RETL1328306-WGS:GSTH-2650-MONOMER.

Family and domain databases

Gene3Di 1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProi IPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view ]
Pfami PF00116. COX2. 1 hit.
[Graphical view ]
SUPFAMi SSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
PROSITEi PS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genes for a second terminal oxidase in Bradyrhizobium japonicum."
    Bott M., Preisig O., Hennecke H.
    Arch. Microbiol. 158:335-343(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: USDA 110spc4.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110.

Entry informationi

Entry nameiCOXM_BRADU
AccessioniPrimary (citable) accession number: P98053
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3