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Protein

Alternative cytochrome c oxidase subunit 2

Gene

coxM

Organism
Bradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi190 – 1901Copper ACurated
Metal bindingi225 – 2251Copper ACurated
Metal bindingi229 – 2291Copper ACurated
Metal bindingi233 – 2331Copper ACurated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciBJAP224911:GJEJ-3809-MONOMER.
RETL1328306-WGS:GSTH-2650-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Alternative cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Alternative cytochrome c oxidase polypeptide II
Cytochrome BB3 subunit 2
Oxidase BB(3) subunit 2
Gene namesi
Name:coxM
Ordered Locus Names:bll3785
OrganismiBradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Taxonomic identifieri224911 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeBradyrhizobium
ProteomesiUP000002526 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4040PeriplasmicSequence AnalysisAdd
BLAST
Transmembranei41 – 6121HelicalSequence AnalysisAdd
BLAST
Topological domaini62 – 8322CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei84 – 10421HelicalSequence AnalysisAdd
BLAST
Topological domaini105 – 277173PeriplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 277277Alternative cytochrome c oxidase subunit 2PRO_0000183724Add
BLAST

Expressioni

Developmental stagei

Bacteroid (nitrogen-fixing endosymbiont).

Interactioni

Protein-protein interaction databases

STRINGi224911.bll3785.

Structurei

3D structure databases

ProteinModelPortaliP98053.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1622.
HOGENOMiHOG000268576.
InParanoidiP98053.
KOiK02275.
OrthoDBiEOG68SVXT.
PhylomeDBiP98053.

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P98053-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVALILLLI AIGSVLFHLF SPWWWTPIAT NWGYIDDTIN ITFWITGFVF
60 70 80 90 100
TAVILFMAYC VFRFHHKEGR QAAYNPENKK LEWWLSVGTG VGVAAMLAPG
110 120 130 140 150
LVVWHQFVTV PADATEVEIM GQQWQWSFRL PGKDGRLGTS DVRNISPENP
160 170 180 190 200
MGLNRDDPHG QDDVVIENGD LHLPIGKPVK VLLRSVDVLH DFYVPEFRAK
210 220 230 240 250
MDMVPGMVTY FWIRPIRTGT FDVLCAELCG AAHYQMRAKV IVEAESDYHA
260 270
WLEQQKTFAG LSGRNAVVRA KYNSGDD
Length:277
Mass (Da):31,327
Last modified:October 1, 1996 - v1
Checksum:iD262ADE2233D36E1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X68547 Genomic DNA. Translation: CAA48547.1.
BA000040 Genomic DNA. Translation: BAC49050.1.
PIRiB48364.
RefSeqiNP_770425.1. NC_004463.1.
WP_011086566.1. NC_004463.1.

Genome annotation databases

EnsemblBacteriaiBAC49050; BAC49050; BAC49050.
GeneIDi1053041.
KEGGibja:bll3785.
PATRICi21191037. VBIBraJap65052_3776.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X68547 Genomic DNA. Translation: CAA48547.1.
BA000040 Genomic DNA. Translation: BAC49050.1.
PIRiB48364.
RefSeqiNP_770425.1. NC_004463.1.
WP_011086566.1. NC_004463.1.

3D structure databases

ProteinModelPortaliP98053.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224911.bll3785.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAC49050; BAC49050; BAC49050.
GeneIDi1053041.
KEGGibja:bll3785.
PATRICi21191037. VBIBraJap65052_3776.

Phylogenomic databases

eggNOGiCOG1622.
HOGENOMiHOG000268576.
InParanoidiP98053.
KOiK02275.
OrthoDBiEOG68SVXT.
PhylomeDBiP98053.

Enzyme and pathway databases

BioCyciBJAP224911:GJEJ-3809-MONOMER.
RETL1328306-WGS:GSTH-2650-MONOMER.

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genes for a second terminal oxidase in Bradyrhizobium japonicum."
    Bott M., Preisig O., Hennecke H.
    Arch. Microbiol. 158:335-343(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: USDA 110spc4.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110.

Entry informationi

Entry nameiCOXM_BRADU
AccessioniPrimary (citable) accession number: P98053
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 27, 2015
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.