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P98053

- COXM_BRADU

UniProt

P98053 - COXM_BRADU

Protein

Alternative cytochrome c oxidase subunit 2

Gene

coxM

Organism
Bradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi190 – 1901Copper ACurated
    Metal bindingi225 – 2251Copper ACurated
    Metal bindingi229 – 2291Copper ACurated
    Metal bindingi233 – 2331Copper ACurated

    GO - Molecular functioni

    1. copper ion binding Source: InterPro
    2. cytochrome-c oxidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. electron transport chain Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Transport

    Keywords - Ligandi

    Copper, Heme, Iron, Metal-binding

    Enzyme and pathway databases

    BioCyciBJAP224911:GJEJ-3809-MONOMER.
    RETL1328306-WGS:GSTH-2650-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alternative cytochrome c oxidase subunit 2 (EC:1.9.3.1)
    Alternative name(s):
    Alternative cytochrome c oxidase polypeptide II
    Cytochrome BB3 subunit 2
    Oxidase BB(3) subunit 2
    Gene namesi
    Name:coxM
    Ordered Locus Names:bll3785
    OrganismiBradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
    Taxonomic identifieri224911 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeBradyrhizobium
    ProteomesiUP000002526: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 277277Alternative cytochrome c oxidase subunit 2PRO_0000183724Add
    BLAST

    Expressioni

    Developmental stagei

    Bacteroid (nitrogen-fixing endosymbiont).

    Interactioni

    Protein-protein interaction databases

    STRINGi224911.bll3785.

    Structurei

    3D structure databases

    ProteinModelPortaliP98053.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4040PeriplasmicSequence AnalysisAdd
    BLAST
    Topological domaini62 – 8322CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini105 – 277173PeriplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei41 – 6121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei84 – 10421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1622.
    HOGENOMiHOG000268576.
    KOiK02275.
    OrthoDBiEOG68SVXT.
    PhylomeDBiP98053.

    Family and domain databases

    Gene3Di1.10.287.90. 1 hit.
    2.60.40.420. 1 hit.
    InterProiIPR001505. Copper_CuA.
    IPR008972. Cupredoxin.
    IPR002429. Cyt_c_oxidase_su2_C.
    IPR011759. Cyt_c_oxidase_su2_TM_dom.
    [Graphical view]
    PfamiPF00116. COX2. 1 hit.
    [Graphical view]
    SUPFAMiSSF49503. SSF49503. 1 hit.
    SSF81464. SSF81464. 1 hit.
    PROSITEiPS00078. COX2. 1 hit.
    PS50857. COX2_CUA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P98053-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAVALILLLI AIGSVLFHLF SPWWWTPIAT NWGYIDDTIN ITFWITGFVF    50
    TAVILFMAYC VFRFHHKEGR QAAYNPENKK LEWWLSVGTG VGVAAMLAPG 100
    LVVWHQFVTV PADATEVEIM GQQWQWSFRL PGKDGRLGTS DVRNISPENP 150
    MGLNRDDPHG QDDVVIENGD LHLPIGKPVK VLLRSVDVLH DFYVPEFRAK 200
    MDMVPGMVTY FWIRPIRTGT FDVLCAELCG AAHYQMRAKV IVEAESDYHA 250
    WLEQQKTFAG LSGRNAVVRA KYNSGDD 277
    Length:277
    Mass (Da):31,327
    Last modified:October 1, 1996 - v1
    Checksum:iD262ADE2233D36E1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X68547 Genomic DNA. Translation: CAA48547.1.
    BA000040 Genomic DNA. Translation: BAC49050.1.
    PIRiB48364.
    RefSeqiNP_770425.1. NC_004463.1.

    Genome annotation databases

    EnsemblBacteriaiBAC49050; BAC49050; BAC49050.
    GeneIDi1053041.
    KEGGibja:bll3785.
    PATRICi21191037. VBIBraJap65052_3776.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X68547 Genomic DNA. Translation: CAA48547.1 .
    BA000040 Genomic DNA. Translation: BAC49050.1 .
    PIRi B48364.
    RefSeqi NP_770425.1. NC_004463.1.

    3D structure databases

    ProteinModelPortali P98053.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 224911.bll3785.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAC49050 ; BAC49050 ; BAC49050 .
    GeneIDi 1053041.
    KEGGi bja:bll3785.
    PATRICi 21191037. VBIBraJap65052_3776.

    Phylogenomic databases

    eggNOGi COG1622.
    HOGENOMi HOG000268576.
    KOi K02275.
    OrthoDBi EOG68SVXT.
    PhylomeDBi P98053.

    Enzyme and pathway databases

    BioCyci BJAP224911:GJEJ-3809-MONOMER.
    RETL1328306-WGS:GSTH-2650-MONOMER.

    Family and domain databases

    Gene3Di 1.10.287.90. 1 hit.
    2.60.40.420. 1 hit.
    InterProi IPR001505. Copper_CuA.
    IPR008972. Cupredoxin.
    IPR002429. Cyt_c_oxidase_su2_C.
    IPR011759. Cyt_c_oxidase_su2_TM_dom.
    [Graphical view ]
    Pfami PF00116. COX2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49503. SSF49503. 1 hit.
    SSF81464. SSF81464. 1 hit.
    PROSITEi PS00078. COX2. 1 hit.
    PS50857. COX2_CUA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genes for a second terminal oxidase in Bradyrhizobium japonicum."
      Bott M., Preisig O., Hennecke H.
      Arch. Microbiol. 158:335-343(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: USDA 110spc4.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110.

    Entry informationi

    Entry nameiCOXM_BRADU
    AccessioniPrimary (citable) accession number: P98053
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3