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Protein

Alternative cytochrome c oxidase subunit 2

Gene

coxM

Organism
Bradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi190Copper ACurated1
Metal bindingi225Copper ACurated1
Metal bindingi229Copper ACurated1
Metal bindingi233Copper ACurated1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Transport
LigandCopper, Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciBDIA224911:G1G3J-3809-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Alternative cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Alternative cytochrome c oxidase polypeptide II
Cytochrome BB3 subunit 2
Oxidase BB(3) subunit 2
Gene namesi
Name:coxM
Ordered Locus Names:bll3785
OrganismiBradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Taxonomic identifieri224911 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeBradyrhizobium
Proteomesi
  • UP000002526 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 40PeriplasmicSequence analysisAdd BLAST40
Transmembranei41 – 61HelicalSequence analysisAdd BLAST21
Topological domaini62 – 83CytoplasmicSequence analysisAdd BLAST22
Transmembranei84 – 104HelicalSequence analysisAdd BLAST21
Topological domaini105 – 277PeriplasmicSequence analysisAdd BLAST173

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001837241 – 277Alternative cytochrome c oxidase subunit 2Add BLAST277

Expressioni

Developmental stagei

Bacteroid (nitrogen-fixing endosymbiont).

Interactioni

Protein-protein interaction databases

STRINGi224911.bll3785

Structurei

3D structure databases

ProteinModelPortaliP98053
SMRiP98053
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105Z4T Bacteria
COG1622 LUCA
HOGENOMiHOG000268576
InParanoidiP98053
KOiK02275
OMAiHYNMQMK
OrthoDBiPOG091H05L4
PhylomeDBiP98053

Family and domain databases

Gene3Di1.10.287.90, 1 hit
2.60.40.420, 1 hit
InterProiView protein in InterPro
IPR002429 CcO_II-like_C
IPR001505 Copper_CuA
IPR008972 Cupredoxin
IPR036257 Cyt_c_oxidase_su2_TM_sf
PfamiView protein in Pfam
PF00116 COX2, 1 hit
SUPFAMiSSF49503 SSF49503, 1 hit
SSF81464 SSF81464, 1 hit
PROSITEiView protein in PROSITE
PS00078 COX2, 1 hit
PS50857 COX2_CUA, 1 hit

Sequencei

Sequence statusi: Complete.

P98053-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVALILLLI AIGSVLFHLF SPWWWTPIAT NWGYIDDTIN ITFWITGFVF
60 70 80 90 100
TAVILFMAYC VFRFHHKEGR QAAYNPENKK LEWWLSVGTG VGVAAMLAPG
110 120 130 140 150
LVVWHQFVTV PADATEVEIM GQQWQWSFRL PGKDGRLGTS DVRNISPENP
160 170 180 190 200
MGLNRDDPHG QDDVVIENGD LHLPIGKPVK VLLRSVDVLH DFYVPEFRAK
210 220 230 240 250
MDMVPGMVTY FWIRPIRTGT FDVLCAELCG AAHYQMRAKV IVEAESDYHA
260 270
WLEQQKTFAG LSGRNAVVRA KYNSGDD
Length:277
Mass (Da):31,327
Last modified:October 1, 1996 - v1
Checksum:iD262ADE2233D36E1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X68547 Genomic DNA Translation: CAA48547.1
BA000040 Genomic DNA Translation: BAC49050.1
PIRiB48364
RefSeqiNP_770425.1, NC_004463.1
WP_011086566.1, NZ_CP011360.1

Genome annotation databases

EnsemblBacteriaiBAC49050; BAC49050; BAC49050
GeneIDi1053041
KEGGibja:bll3785
PATRICifig|224911.44.peg.3453

Similar proteinsi

Entry informationi

Entry nameiCOXM_BRADU
AccessioniPrimary (citable) accession number: P98053
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 25, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health