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Protein

Cytochrome c oxidase subunit 2

Gene

cbaB

Organism
Thermus thermophilus
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi81Copper A1
Metal bindingi116Copper A1
Metal bindingi120Copper A1
Metal bindingi124Copper A1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c ba(3) subunit II
Cytochrome c oxidase polypeptide II
Cytochrome cba3 subunit 2
Gene namesi
Name:cbaB
Synonyms:ctaC
OrganismiThermus thermophilus
Taxonomic identifieri274 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000183721‹1 – 135Cytochrome c oxidase subunit 2Add BLAST›135

Interactioni

Protein-protein interaction databases

IntActiP98052. 1 interactor.
STRINGi262724.TTC0769.

Structurei

Secondary structure

1135
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi1 – 5Combined sources5
Helixi7 – 11Combined sources5
Beta strandi15 – 19Combined sources5
Turni22 – 27Combined sources6
Turni30 – 32Combined sources3
Helixi34 – 36Combined sources3
Beta strandi38 – 42Combined sources5
Beta strandi45 – 53Combined sources9
Beta strandi56 – 65Combined sources10
Beta strandi68 – 79Combined sources12
Beta strandi81 – 85Combined sources5
Turni86 – 89Combined sources4
Beta strandi91 – 94Combined sources4
Beta strandi96 – 99Combined sources4
Beta strandi100 – 105Combined sources6
Beta strandi110 – 115Combined sources6
Helixi124 – 126Combined sources3
Beta strandi128 – 134Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1XMEX-ray2.30B1-135[»]
2CUAX-ray1.60A/B1-135[»]
2FWLNMR-B1-135[»]
2LLNNMR-A11-135[»]
ProteinModelPortaliP98052.
SMRiP98052.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP98052.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane

Phylogenomic databases

eggNOGiENOG4105NAA. Bacteria.
COG1622. LUCA.

Family and domain databases

Gene3Di2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR002429. Cyt_c_oxidase_su2_C.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

P98052-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
AYTLATHTAG VIPAGKLERV DPTTVRQEGP WADPAQAVVQ TGPNQYTVYV
60 70 80 90 100
LAFAFGYQPN PIEVPQGAEI VFKITSPDVI HGFHVEGTNI NVEVLPGEVS
110 120 130
TVRYTFKRPG EYRIICNQYC GLGHQNMFGT IVVKE
Length:135
Mass (Da):14,804
Last modified:May 24, 2005 - v2
Checksum:i786895A803A52FAB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Cross-referencesi

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1XMEX-ray2.30B1-135[»]
2CUAX-ray1.60A/B1-135[»]
2FWLNMR-B1-135[»]
2LLNNMR-A11-135[»]
ProteinModelPortaliP98052.
SMRiP98052.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP98052. 1 interactor.
STRINGi262724.TTC0769.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG4105NAA. Bacteria.
COG1622. LUCA.

Miscellaneous databases

EvolutionaryTraceiP98052.

Family and domain databases

Gene3Di2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR002429. Cyt_c_oxidase_su2_C.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCOX2_THETH
AccessioniPrimary (citable) accession number: P98052
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: May 24, 2005
Last modified: November 2, 2016
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

The sequence shown here has been extracted from PDB entry 2CUA.Curated

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.