P98052 (COX2_THETH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome c oxidase subunit 2
EC=1.9.3.1

Alternative name(s):
Cytochrome c ba(3) subunit II
Cytochrome c oxidase polypeptide II
Cytochrome cba3 subunit 2

Gene names

Name:	cbaB
Synonyms:	ctaC

Organism

Thermus thermophilus

Taxonomic identifier

274 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Deinococcus-Thermus › Deinococci › Thermales › Thermaceae › Thermus

Protein attributes

Sequence length	135 AA.
Sequence status	Fragment.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).
Catalytic activity	4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.
Subcellular location	Cell membrane; Peripheral membrane protein.
Sequence similarities	Belongs to the cytochrome c oxidase subunit 2 family.
Caution	The sequence shown here has been extracted from PDB entry 2CUA.

Ontologies

Keywords
Biological process	Electron transport Respiratory chain Transport
Cellular component	Cell membrane Membrane
Domain	Transmembrane
Ligand	Copper Metal-binding
Molecular function	Oxidoreductase
Technical term	3D-structure
Gene Ontology (GO)
Biological_process	electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell respiratory chain Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	copper ion binding Inferred from electronic annotation. Source: InterPro cytochrome-c oxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

‹1 – 135

›135

Cytochrome c oxidase subunit 2

PRO_0000183721

Sites

Metal binding

81

1

Copper A

Metal binding

116

1

Copper A

Metal binding

120

1

Copper A

Metal binding

124

1

Copper A

Experimental info

Non-terminal residue

1

1

Secondary structure

1

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135

Helix Strand Turn

Details...

Helix

1 – 5

5

Helix

7 – 11

5

Beta strand

15 – 19

5

Turn

22 – 27

6

Turn

30 – 32

3

Helix

34 – 36

3

Beta strand

38 – 42

5

Beta strand

45 – 53

9

Beta strand

56 – 65

10

Beta strand

68 – 79

12

Beta strand

81 – 85

5

Turn

86 – 89

4

Beta strand

91 – 94

4

Beta strand

96 – 99

4

Beta strand

100 – 105

6

Beta strand

110 – 115

6

Helix

124 – 126

3

Beta strand

128 – 134

7

Sequences

	Sequence		Length	Mass (Da)
	P98052 [UniParc]. Last modified May 24, 2005. Version 2. Checksum: 786895A803A52FAB	FASTA	135	14,804
	10 20 30 40 50 60 AYTLATHTAG VIPAGKLERV DPTTVRQEGP WADPAQAVVQ TGPNQYTVYV LAFAFGYQPN 70 80 90 100 110 120 PIEVPQGAEI VFKITSPDVI HGFHVEGTNI NVEVLPGEVS TVRYTFKRPG EYRIICNQYC 130 GLGHQNMFGT IVVKE

References

[1]	"The CuA domain of Thermus thermophilus ba3-type cytochrome c oxidase at 1.6-A resolution." Williams P.A., Blackburn N.J., Sanders D., Bellamy H., Stura E.A., Fee J.A., McRee D.E. Nat. Struct. Biol. 6:509-516(1999) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.6 ANGSTROMS).
+	Additional computationally mapped references.

Cross-references

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1XME	X-ray	2.30	B	1-135	[»]
2CUA	X-ray	1.60	A/B	1-135	[»]
2FWL	NMR	-	B	1-135	[»]
2LLN	NMR	-	A	11-135	[»]

ProteinModelPortal

P98052.

SMR

P98052. Positions 1-135.

ModBase

Search...

Protein-protein interaction databases

IntAct

P98052. 1 interaction.

STRING

262724.TTC0769.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Family and domain databases

Gene3D

2.60.40.420. 1 hit.

InterPro

IPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR002429. Cyt_c_oxidase_su2_C.
[Graphical view]

Pfam

PF00116. COX2. 1 hit.
[Graphical view]

SUPFAM

SSF49503. Cupredoxin. 1 hit.

PROSITE

PS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

P98052.

Entry information

Entry name

COX2_THETH

Accession

Primary (citable) accession number: P98052

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	May 24, 2005
Last modified:	April 3, 2013
This is version 95 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program