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P98052 (COX2_THETH) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 2

EC=1.9.3.1
Alternative name(s):
Cytochrome c ba(3) subunit II
Cytochrome c oxidase polypeptide II
Cytochrome cba3 subunit 2
Gene names
Name:cbaB
Synonyms:ctaC
OrganismThermus thermophilus
Taxonomic identifier274 [NCBI]
Taxonomic lineageBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus

Protein attributes

Sequence length135 AA.
Sequence statusFragment.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Subcellular location

Cell membrane; Peripheral membrane protein.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 2 family.

Caution

The sequence shown here has been extracted from PDB entry 2CUA.

Ontologies

Keywords
   Biological processElectron transport
Respiratory chain
Transport
   Cellular componentCell membrane
Membrane
   DomainTransmembrane
   LigandCopper
Metal-binding
   Molecular functionOxidoreductase
   Technical term3D-structure
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

respiratory chain

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functioncopper ion binding

Inferred from electronic annotation. Source: InterPro

cytochrome-c oxidase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – 135›135Cytochrome c oxidase subunit 2
PRO_0000183721

Sites

Metal binding811Copper A
Metal binding1161Copper A
Metal binding1201Copper A
Metal binding1241Copper A

Experimental info

Non-terminal residue11

Secondary structure

.................................. 135
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P98052 [UniParc].

Last modified May 24, 2005. Version 2.
Checksum: 786895A803A52FAB

FASTA13514,804
        10         20         30         40         50         60 
AYTLATHTAG VIPAGKLERV DPTTVRQEGP WADPAQAVVQ TGPNQYTVYV LAFAFGYQPN 

        70         80         90        100        110        120 
PIEVPQGAEI VFKITSPDVI HGFHVEGTNI NVEVLPGEVS TVRYTFKRPG EYRIICNQYC 

       130 
GLGHQNMFGT IVVKE 

« Hide

References

[1]"The CuA domain of Thermus thermophilus ba3-type cytochrome c oxidase at 1.6-A resolution."
Williams P.A., Blackburn N.J., Sanders D., Bellamy H., Stura E.A., Fee J.A., McRee D.E.
Nat. Struct. Biol. 6:509-516(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.6 ANGSTROMS).
+Additional computationally mapped references.

Cross-references

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1XMEX-ray2.30B1-135[»]
2CUAX-ray1.60A/B1-135[»]
2FWLNMR-B1-135[»]
2LLNNMR-A11-135[»]
ProteinModelPortalP98052.
SMRP98052. Positions 1-135.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP98052. 1 interaction.
STRING262724.TTC0769.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D2.60.40.420. 1 hit.
InterProIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR002429. Cyt_c_oxidase_su2_C.
[Graphical view]
PfamPF00116. COX2. 1 hit.
[Graphical view]
SUPFAMSSF49503. SSF49503. 1 hit.
PROSITEPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP98052.

Entry information

Entry nameCOX2_THETH
AccessionPrimary (citable) accession number: P98052
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: May 24, 2005
Last modified: April 16, 2014
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references