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P98052

- COX2_THETH

UniProt

P98052 - COX2_THETH

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Protein
Cytochrome c oxidase subunit 2
Gene
cbaB, ctaC
Organism
Thermus thermophilus
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi81 – 811Copper A
Metal bindingi116 – 1161Copper A
Metal bindingi120 – 1201Copper A
Metal bindingi124 – 1241Copper A

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. cytochrome-c oxidase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c ba(3) subunit II
Cytochrome c oxidase polypeptide II
Cytochrome cba3 subunit 2
Gene namesi
Name:cbaB
Synonyms:ctaC
OrganismiThermus thermophilus
Taxonomic identifieri274 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – 135›135Cytochrome c oxidase subunit 2
PRO_0000183721Add
BLAST

Interactioni

Protein-protein interaction databases

IntActiP98052. 1 interaction.
STRINGi262724.TTC0769.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi1 – 55
Helixi7 – 115
Beta strandi15 – 195
Turni22 – 276
Turni30 – 323
Helixi34 – 363
Beta strandi38 – 425
Beta strandi45 – 539
Beta strandi56 – 6510
Beta strandi68 – 7912
Beta strandi81 – 855
Turni86 – 894
Beta strandi91 – 944
Beta strandi96 – 994
Beta strandi100 – 1056
Beta strandi110 – 1156
Helixi124 – 1263
Beta strandi128 – 1347

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1XMEX-ray2.30B1-135[»]
2CUAX-ray1.60A/B1-135[»]
2FWLNMR-B1-135[»]
2LLNNMR-A11-135[»]
ProteinModelPortaliP98052.
SMRiP98052. Positions 1-135.

Miscellaneous databases

EvolutionaryTraceiP98052.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane

Family and domain databases

Gene3Di2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR002429. Cyt_c_oxidase_su2_C.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

P98052-1 [UniParc]FASTAAdd to Basket

« Hide

AYTLATHTAG VIPAGKLERV DPTTVRQEGP WADPAQAVVQ TGPNQYTVYV    50
LAFAFGYQPN PIEVPQGAEI VFKITSPDVI HGFHVEGTNI NVEVLPGEVS 100
TVRYTFKRPG EYRIICNQYC GLGHQNMFGT IVVKE 135
Length:135
Mass (Da):14,804
Last modified:May 24, 2005 - v2
Checksum:i786895A803A52FAB
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Cross-referencesi

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1XME X-ray 2.30 B 1-135 [» ]
2CUA X-ray 1.60 A/B 1-135 [» ]
2FWL NMR - B 1-135 [» ]
2LLN NMR - A 11-135 [» ]
ProteinModelPortali P98052.
SMRi P98052. Positions 1-135.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P98052. 1 interaction.
STRINGi 262724.TTC0769.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei P98052.

Family and domain databases

Gene3Di 2.60.40.420. 1 hit.
InterProi IPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR002429. Cyt_c_oxidase_su2_C.
[Graphical view ]
Pfami PF00116. COX2. 1 hit.
[Graphical view ]
SUPFAMi SSF49503. SSF49503. 1 hit.
PROSITEi PS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The CuA domain of Thermus thermophilus ba3-type cytochrome c oxidase at 1.6-A resolution."
    Williams P.A., Blackburn N.J., Sanders D., Bellamy H., Stura E.A., Fee J.A., McRee D.E.
    Nat. Struct. Biol. 6:509-516(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.6 ANGSTROMS).

Entry informationi

Entry nameiCOX2_THETH
AccessioniPrimary (citable) accession number: P98052
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: May 24, 2005
Last modified: April 16, 2014
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

The sequence shown here has been extracted from PDB entry 2CUA.

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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