Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P98052

- COX2_THETH

UniProt

P98052 - COX2_THETH

Protein

Cytochrome c oxidase subunit 2

Gene

cbaB

Organism
Thermus thermophilus
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi81 – 811Copper A
    Metal bindingi116 – 1161Copper A
    Metal bindingi120 – 1201Copper A
    Metal bindingi124 – 1241Copper A

    GO - Molecular functioni

    1. copper ion binding Source: InterPro
    2. cytochrome-c oxidase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    Copper, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome c ba(3) subunit II
    Cytochrome c oxidase polypeptide II
    Cytochrome cba3 subunit 2
    Gene namesi
    Name:cbaB
    Synonyms:ctaC
    OrganismiThermus thermophilus
    Taxonomic identifieri274 [NCBI]
    Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell
    3. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini‹1 – 135›135Cytochrome c oxidase subunit 2PRO_0000183721Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    IntActiP98052. 1 interaction.
    STRINGi262724.TTC0769.

    Structurei

    Secondary structure

    135
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi1 – 55
    Helixi7 – 115
    Beta strandi15 – 195
    Turni22 – 276
    Turni30 – 323
    Helixi34 – 363
    Beta strandi38 – 425
    Beta strandi45 – 539
    Beta strandi56 – 6510
    Beta strandi68 – 7912
    Beta strandi81 – 855
    Turni86 – 894
    Beta strandi91 – 944
    Beta strandi96 – 994
    Beta strandi100 – 1056
    Beta strandi110 – 1156
    Helixi124 – 1263
    Beta strandi128 – 1347

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1XMEX-ray2.30B1-135[»]
    2CUAX-ray1.60A/B1-135[»]
    2FWLNMR-B1-135[»]
    2LLNNMR-A11-135[»]
    ProteinModelPortaliP98052.
    SMRiP98052. Positions 1-135.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP98052.

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane

    Family and domain databases

    Gene3Di2.60.40.420. 1 hit.
    InterProiIPR001505. Copper_CuA.
    IPR008972. Cupredoxin.
    IPR002429. Cyt_c_oxidase_su2_C.
    [Graphical view]
    PfamiPF00116. COX2. 1 hit.
    [Graphical view]
    SUPFAMiSSF49503. SSF49503. 1 hit.
    PROSITEiPS00078. COX2. 1 hit.
    PS50857. COX2_CUA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    P98052-1 [UniParc]FASTAAdd to Basket

    « Hide

    AYTLATHTAG VIPAGKLERV DPTTVRQEGP WADPAQAVVQ TGPNQYTVYV    50
    LAFAFGYQPN PIEVPQGAEI VFKITSPDVI HGFHVEGTNI NVEVLPGEVS 100
    TVRYTFKRPG EYRIICNQYC GLGHQNMFGT IVVKE 135
    Length:135
    Mass (Da):14,804
    Last modified:May 24, 2005 - v2
    Checksum:i786895A803A52FAB
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11

    Cross-referencesi

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1XME X-ray 2.30 B 1-135 [» ]
    2CUA X-ray 1.60 A/B 1-135 [» ]
    2FWL NMR - B 1-135 [» ]
    2LLN NMR - A 11-135 [» ]
    ProteinModelPortali P98052.
    SMRi P98052. Positions 1-135.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P98052. 1 interaction.
    STRINGi 262724.TTC0769.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Miscellaneous databases

    EvolutionaryTracei P98052.

    Family and domain databases

    Gene3Di 2.60.40.420. 1 hit.
    InterProi IPR001505. Copper_CuA.
    IPR008972. Cupredoxin.
    IPR002429. Cyt_c_oxidase_su2_C.
    [Graphical view ]
    Pfami PF00116. COX2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49503. SSF49503. 1 hit.
    PROSITEi PS00078. COX2. 1 hit.
    PS50857. COX2_CUA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The CuA domain of Thermus thermophilus ba3-type cytochrome c oxidase at 1.6-A resolution."
      Williams P.A., Blackburn N.J., Sanders D., Bellamy H., Stura E.A., Fee J.A., McRee D.E.
      Nat. Struct. Biol. 6:509-516(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.6 ANGSTROMS).

    Entry informationi

    Entry nameiCOX2_THETH
    AccessioniPrimary (citable) accession number: P98052
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: May 24, 2005
    Last modified: October 1, 2014
    This is version 100 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Caution

    The sequence shown here has been extracted from PDB entry 2CUA.Curated

    Keywords - Technical termi

    3D-structure

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3