P98023 (COX2_TRYCR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome c oxidase subunit 2
EC=1.9.3.1

Alternative name(s):
Cytochrome c oxidase polypeptide II

Gene names

Name:

COXII

Encoded on

Mitochondrion

Organism

Trypanosoma cruzi

Taxonomic identifier

5693 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Euglenozoa › Kinetoplastida › Trypanosomatidae › Trypanosoma › Schizotrypanum

Protein attributes

Sequence length	210 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.
Catalytic activity	4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.
Cofactor	Copper A.
Subcellular location	Mitochondrion inner membrane; Multi-pass membrane protein.
Developmental stage	Same abundance in amastigote, epimastigote, and trypomastigote.
Sequence similarities	Belongs to the cytochrome c oxidase subunit 2 family.
RNA editing	Modified position: not applicable. Some positions are modified by RNA editing via nucleotide insertion. Ref.1

Ontologies

Keywords
Biological process	Electron transport Respiratory chain Transport
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Coding sequence diversity	RNA editing
Domain	Transmembrane Transmembrane helix
Ligand	Copper Metal-binding
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological_process	electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-SubCell respiratory chain Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	copper ion binding Inferred from electronic annotation. Source: InterPro cytochrome-c oxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 210	210	Cytochrome c oxidase subunit 2		PRO_0000183708
Regions
	Topological domain	1 – 15	15	Mitochondrial intermembrane Potential
	Transmembrane	16 – 36	21	Helical; Potential
	Topological domain	37 – 63	27	Mitochondrial matrix Potential
	Transmembrane	64 – 84	21	Helical; Potential
	Topological domain	85 – 210	126	Mitochondrial intermembrane Potential
Sites
	Metal binding	157	1	Copper A Probable
	Metal binding	192	1	Copper A Probable
	Metal binding	196	1	Copper A Probable
	Metal binding	200	1	Copper A Probable
Natural variations
	Natural variant	186	1	A → P in strain: Tulahuen.

Sequences

	Sequence		Length	Mass (Da)
	P98023 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 82F55498FF1D214E	FASTA	210	24,145
	10 20 30 40 50 60 MSFILSFWMI FLIDSVIVLL SFVCFVCVWI CVLLLSTVLF VTKINNIYCT WDFVSSKFVD 70 80 90 100 110 120 TYWFVIGVMF IMCLLLRLCL LLYFGCLNFV SFDLCKVVGF QWYWVYFLFG ETTIFSNLIL 130 140 150 160 170 180 ESDYLVGDMR LLQCNHVLTL LSLVIYKLWV SAVDVIHSFT LASLGIKVDC IPGRCNEIIL 190 200 210 FASNNATIYG QCSELCGVLH GFMPIVICFI

References

[1]	"Transcription and editing of cytochrome oxidase II RNAs in Trypanosoma cruzi." Kim K.S., Teixeira S.M., Kirchhoff L.V., Donelson J.E. J. Biol. Chem. 269:1206-1211(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], RNA EDITING. Strain: Corpus Christi, Tulahuen and Y.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L22643 mRNA. Translation: AAA16806.1.
PIR	A49872.
3D structure databases
ProteinModelPortal	P98023.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	2.60.40.420. 1 hit.
InterPro	IPR001505. Copper_CuA. IPR008972. Cupredoxin. IPR002429. Cyt_c_oxidase_su2_C. [Graphical view]
Pfam	PF00116. COX2. 1 hit. [Graphical view]
SUPFAM	SSF49503. Cupredoxin. 1 hit.
PROSITE	PS00078. COX2. 1 hit. PS50857. COX2_CUA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

COX2_TRYCR

Accession

Primary (citable) accession number: P98023

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	April 3, 2013
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)