SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P98023

- COX2_TRYCR

UniProt

P98023 - COX2_TRYCR

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Cytochrome c oxidase subunit 2
Gene
COXII
Organism
Trypanosoma cruzi
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Copper A.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi157 – 1571Copper A Inferred
Metal bindingi192 – 1921Copper A Inferred
Metal bindingi196 – 1961Copper A Inferred
Metal bindingi200 – 2001Copper A Inferred

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. cytochrome-c oxidase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene namesi
Name:COXII
Encoded oniMitochondrion
OrganismiTrypanosoma cruzi
Taxonomic identifieri5693 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosomaSchizotrypanum

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1515Mitochondrial intermembrane Reviewed prediction
Add
BLAST
Transmembranei16 – 3621Helical; Reviewed prediction
Add
BLAST
Topological domaini37 – 6327Mitochondrial matrix Reviewed prediction
Add
BLAST
Transmembranei64 – 8421Helical; Reviewed prediction
Add
BLAST
Topological domaini85 – 210126Mitochondrial intermembrane Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 210210Cytochrome c oxidase subunit 2
PRO_0000183708Add
BLAST

Expressioni

Developmental stagei

Same abundance in amastigote, epimastigote, and trypomastigote.

Structurei

3D structure databases

ProteinModelPortaliP98023.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR002429. Cyt_c_oxidase_su2_C.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P98023-1 [UniParc]FASTAAdd to Basket

« Hide

MSFILSFWMI FLIDSVIVLL SFVCFVCVWI CVLLLSTVLF VTKINNIYCT    50
WDFVSSKFVD TYWFVIGVMF IMCLLLRLCL LLYFGCLNFV SFDLCKVVGF 100
QWYWVYFLFG ETTIFSNLIL ESDYLVGDMR LLQCNHVLTL LSLVIYKLWV 150
SAVDVIHSFT LASLGIKVDC IPGRCNEIIL FASNNATIYG QCSELCGVLH 200
GFMPIVICFI 210
Length:210
Mass (Da):24,145
Last modified:October 1, 1996 - v1
Checksum:i82F55498FF1D214E
GO

RNA editingi

Some positions are modified by RNA editing via nucleotide insertion.1 Publication

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti186 – 1861A → P in strain: Tulahuen.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L22643 mRNA. Translation: AAA16806.1.
PIRiA49872.

Keywords - Coding sequence diversityi

RNA editing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L22643 mRNA. Translation: AAA16806.1 .
PIRi A49872.

3D structure databases

ProteinModelPortali P98023.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 2.60.40.420. 1 hit.
InterProi IPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR002429. Cyt_c_oxidase_su2_C.
[Graphical view ]
Pfami PF00116. COX2. 1 hit.
[Graphical view ]
SUPFAMi SSF49503. SSF49503. 1 hit.
PROSITEi PS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Transcription and editing of cytochrome oxidase II RNAs in Trypanosoma cruzi."
    Kim K.S., Teixeira S.M., Kirchhoff L.V., Donelson J.E.
    J. Biol. Chem. 269:1206-1211(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], RNA EDITING.
    Strain: Corpus Christi, Tulahuen and Y.

Entry informationi

Entry nameiCOX2_TRYCR
AccessioniPrimary (citable) accession number: P98023
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 16, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi