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P98023 (COX2_TRYCR) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 2

EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene names
Name:COXII
Encoded onMitochondrion
OrganismTrypanosoma cruzi
Taxonomic identifier5693 [NCBI]
Taxonomic lineageEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosomaSchizotrypanum

Protein attributes

Sequence length210 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactor

Copper A.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein.

Developmental stage

Same abundance in amastigote, epimastigote, and trypomastigote.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 2 family.

RNA editing

Modified position: not applicable.
Some positions are modified by RNA editing via nucleotide insertion. Ref.1

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 210210Cytochrome c oxidase subunit 2
PRO_0000183708

Regions

Topological domain1 – 1515Mitochondrial intermembrane Potential
Transmembrane16 – 3621Helical; Potential
Topological domain37 – 6327Mitochondrial matrix Potential
Transmembrane64 – 8421Helical; Potential
Topological domain85 – 210126Mitochondrial intermembrane Potential

Sites

Metal binding1571Copper A Probable
Metal binding1921Copper A Probable
Metal binding1961Copper A Probable
Metal binding2001Copper A Probable

Natural variations

Natural variant1861A → P in strain: Tulahuen.

Sequences

Sequence LengthMass (Da)Tools
P98023 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 82F55498FF1D214E

FASTA21024,145
        10         20         30         40         50         60 
MSFILSFWMI FLIDSVIVLL SFVCFVCVWI CVLLLSTVLF VTKINNIYCT WDFVSSKFVD 

        70         80         90        100        110        120 
TYWFVIGVMF IMCLLLRLCL LLYFGCLNFV SFDLCKVVGF QWYWVYFLFG ETTIFSNLIL 

       130        140        150        160        170        180 
ESDYLVGDMR LLQCNHVLTL LSLVIYKLWV SAVDVIHSFT LASLGIKVDC IPGRCNEIIL 

       190        200        210 
FASNNATIYG QCSELCGVLH GFMPIVICFI 

« Hide

References

[1]"Transcription and editing of cytochrome oxidase II RNAs in Trypanosoma cruzi."
Kim K.S., Teixeira S.M., Kirchhoff L.V., Donelson J.E.
J. Biol. Chem. 269:1206-1211(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], RNA EDITING.
Strain: Corpus Christi, Tulahuen and Y.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L22643 mRNA. Translation: AAA16806.1.
PIRA49872.

3D structure databases

ProteinModelPortalP98023.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D2.60.40.420. 1 hit.
InterProIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR002429. Cyt_c_oxidase_su2_C.
[Graphical view]
PfamPF00116. COX2. 1 hit.
[Graphical view]
SUPFAMSSF49503. SSF49503. 1 hit.
PROSITEPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX2_TRYCR
AccessionPrimary (citable) accession number: P98023
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 16, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families