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P98021

- COX2_SIMVI

UniProt

P98021 - COX2_SIMVI

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Protein
Cytochrome c oxidase subunit 2
Gene
COII
Organism
Simulium vittatum (Striped black fly)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Copper A.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi161 – 1611Copper A Inferred
Metal bindingi196 – 1961Copper A Inferred
Metal bindingi200 – 2001Copper A Inferred
Metal bindingi204 – 2041Copper A Inferred

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. cytochrome-c oxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. electron transport chain Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene namesi
Name:COII
Encoded oniMitochondrion
OrganismiSimulium vittatum (Striped black fly)
Taxonomic identifieri7192 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraNematoceraChironomoideaSimuliidaeSimulium

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2626Mitochondrial intermembrane Reviewed prediction
Add
BLAST
Transmembranei27 – 4822Helical; Reviewed prediction
Add
BLAST
Topological domaini49 – 6214Mitochondrial matrix Reviewed prediction
Add
BLAST
Transmembranei63 – 8220Helical; Reviewed prediction
Add
BLAST
Topological domaini83 – 229147Mitochondrial intermembrane Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 229229Cytochrome c oxidase subunit 2
PRO_0000183690Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP98021.
SMRiP98021. Positions 7-226.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsiTIGR02866. CoxB. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P98021-1 [UniParc]FASTAAdd to Basket

« Hide

MATWSNLGLQ DSASPLMEQL NFFHDHTLLI LIMITILVGY LMLMLFFNKF    50
TNRFLLHGQT IEIIWTILPA IVLMFIALPS LRILYLLDEI NSPAITLKTI 100
GHQWYWSYEY SDFMNLEFDS YMVPTNELET NGFRLLDVDN RIVLPMNTQI 150
RILVTAADVI HSWTVPALGV KVDGTPGRLN QTNFLMNRPG LFFGQCSEIC 200
GANHSFMPIV LESSPTNYFI KWITAMNSN 229
Length:229
Mass (Da):26,275
Last modified:October 1, 1996 - v1
Checksum:i388B5F940EFA4A64
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M76433 Genomic DNA. Translation: AAA32072.1.
AF083865 Genomic DNA. Translation: AAC64095.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M76433 Genomic DNA. Translation: AAA32072.1 .
AF083865 Genomic DNA. Translation: AAC64095.1 .

3D structure databases

ProteinModelPortali P98021.
SMRi P98021. Positions 7-226.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProi IPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view ]
Pfami PF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view ]
SUPFAMi SSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsi TIGR02866. CoxB. 1 hit.
PROSITEi PS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Mitochondrial transfer RNA genes in a black fly, Simulium vittatum (Diptera: Simuliidae), indicate long divergence from mosquito (Diptera: Culicidae) and fruit fly (Diptera: Drosophilidae)."
    Pruess K.P., Zhu X., Powers T.O.
    J. Med. Entomol. 29:644-651(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Phylogenetic relationships of black flies (Diptera: Simuliidae) inferred from the mitochondrial cytochrome oxidase II gene."
    Pruess K.P., Adams B.J., Parsons T.J., Zhu X., Powers T.O.
    Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiCOX2_SIMVI
AccessioniPrimary (citable) accession number: P98021
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 16, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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