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P98019 (COX2_ANAPL) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 2

EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene names
Name:MT-CO2
Synonyms:COII, COXII, MTCO2
Encoded onMitochondrion
OrganismAnas platyrhynchos (Domestic duck) (Anas boschas) [Complete proteome]
Taxonomic identifier8839 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeAnseriformesAnatidaeAnas

Protein attributes

Sequence length228 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactor

Copper A.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 2 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 228228Cytochrome c oxidase subunit 2
PRO_0000183492

Regions

Topological domain1 – 2626Mitochondrial intermembrane Potential
Transmembrane27 – 4721Helical; Potential
Topological domain48 – 6114Mitochondrial matrix Potential
Transmembrane62 – 8120Helical; Potential
Topological domain82 – 228147Mitochondrial intermembrane Potential

Sites

Metal binding1601Copper A Probable
Metal binding1951Copper A Probable
Metal binding1991Copper A Probable
Metal binding2031Copper A Probable

Sequences

Sequence LengthMass (Da)Tools
P98019 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: E1C4FE82797DBE03

FASTA22825,554
        10         20         30         40         50         60 
MANHSQLGFQ DASSPIMEEL VEFHDHALIV ALAICSLVLY LLAHMLMEKL SSNAVDAQEV 

        70         80         90        100        110        120 
ELIWTILPAI VLVLLALPSL QILYMMDEID EPDLTLKAIG HQWYWSYEYT DFKDLSFDSY 

       130        140        150        160        170        180 
MIPTTDLPNG HFRLLEVDHR VVVPMESPIR VIITAGDVLH SWAVPTLGVK TDAIPGRLNQ 

       190        200        210        220 
TSFITTRPGI FYGQCSEICG ANHSYMPIVV ESTPLPYFEA WSSLLSSS 

« Hide

References

[1]"Molecular characterization and evolution of a duck mitochondrial genome."
Ramirez V., Savoie P., Morais R.
J. Mol. Evol. 37:296-310(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Pekin breed.
Tissue: Liver.
[2]"A gene cytochrome C oxidase subunit II in duck mitochondrial DNA: structural features and sequence evolution."
Pan Y.F., Lee Y.H.W., Wei Y.H., Chiang A.N.
Biochem. Int. 30:479-489(1993)
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Pekin breed.
Tissue: Liver.
[3]"Gene organization of the Peking duck mitochondrial genome."
Desjardins P., Ramirez V., Morais R.
Curr. Genet. 17:515-518(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 22-54.
Strain: Pekin breed.
Tissue: Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L22476 Genomic DNA. Translation: AAA72039.1.
X68507 Genomic DNA. Translation: CAA48519.1.
X55531 Genomic DNA. Translation: CAA39147.1.
RefSeqYP_001382249.1. NC_009684.1.

3D structure databases

ProteinModelPortalP98019.
SMRP98019. Positions 1-223.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5405812.
KEGGapla:5405812.

Organism-specific databases

CTD4513.

Phylogenomic databases

HOVERGENHBG012727.
KOK02261.

Family and domain databases

Gene3D1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsTIGR02866. CoxB. 1 hit.
PROSITEPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX2_ANAPL
AccessionPrimary (citable) accession number: P98019
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 14, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families