Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P98019

- COX2_ANAPL

UniProt

P98019 - COX2_ANAPL

Protein

Cytochrome c oxidase subunit 2

Gene

MT-CO2

Organism
Anas platyrhynchos (Domestic duck) (Anas boschas)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    Cofactori

    Copper A.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi160 – 1601Copper ACurated
    Metal bindingi195 – 1951Copper ACurated
    Metal bindingi199 – 1991Copper ACurated
    Metal bindingi203 – 2031Copper ACurated

    GO - Molecular functioni

    1. copper ion binding Source: InterPro
    2. cytochrome-c oxidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. electron transport chain Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    Copper, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome c oxidase polypeptide II
    Gene namesi
    Name:MT-CO2
    Synonyms:COII, COXII, MTCO2
    Encoded oniMitochondrion
    OrganismiAnas platyrhynchos (Domestic duck) (Anas boschas)
    Taxonomic identifieri8839 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeAnseriformesAnatidaeAnas
    ProteomesiUP000016666: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: UniProtKB-SubCell
    3. respiratory chain complex IV Source: UniProtKB

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 228228Cytochrome c oxidase subunit 2PRO_0000183492Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP98019.
    SMRiP98019. Positions 1-223.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2626Mitochondrial intermembraneSequence AnalysisAdd
    BLAST
    Topological domaini48 – 6114Mitochondrial matrixSequence AnalysisAdd
    BLAST
    Topological domaini82 – 228147Mitochondrial intermembraneSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei27 – 4721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei62 – 8120HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOVERGENiHBG012727.
    KOiK02261.

    Family and domain databases

    Gene3Di1.10.287.90. 1 hit.
    2.60.40.420. 1 hit.
    InterProiIPR001505. Copper_CuA.
    IPR008972. Cupredoxin.
    IPR014222. Cyt_c_oxidase_su2.
    IPR002429. Cyt_c_oxidase_su2_C.
    IPR011759. Cyt_c_oxidase_su2_TM_dom.
    [Graphical view]
    PfamiPF00116. COX2. 1 hit.
    PF02790. COX2_TM. 1 hit.
    [Graphical view]
    SUPFAMiSSF49503. SSF49503. 1 hit.
    SSF81464. SSF81464. 1 hit.
    TIGRFAMsiTIGR02866. CoxB. 1 hit.
    PROSITEiPS00078. COX2. 1 hit.
    PS50857. COX2_CUA. 1 hit.
    PS50999. COX2_TM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P98019-1 [UniParc]FASTAAdd to Basket

    « Hide

    MANHSQLGFQ DASSPIMEEL VEFHDHALIV ALAICSLVLY LLAHMLMEKL    50
    SSNAVDAQEV ELIWTILPAI VLVLLALPSL QILYMMDEID EPDLTLKAIG 100
    HQWYWSYEYT DFKDLSFDSY MIPTTDLPNG HFRLLEVDHR VVVPMESPIR 150
    VIITAGDVLH SWAVPTLGVK TDAIPGRLNQ TSFITTRPGI FYGQCSEICG 200
    ANHSYMPIVV ESTPLPYFEA WSSLLSSS 228
    Length:228
    Mass (Da):25,554
    Last modified:October 1, 1996 - v1
    Checksum:iE1C4FE82797DBE03
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L22476 Genomic DNA. Translation: AAA72039.1.
    X68507 Genomic DNA. Translation: CAA48519.1.
    X55531 Genomic DNA. Translation: CAA39147.1.
    RefSeqiYP_001382249.1. NC_009684.1.

    Genome annotation databases

    GeneIDi5405812.
    KEGGiapla:5405812.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L22476 Genomic DNA. Translation: AAA72039.1 .
    X68507 Genomic DNA. Translation: CAA48519.1 .
    X55531 Genomic DNA. Translation: CAA39147.1 .
    RefSeqi YP_001382249.1. NC_009684.1.

    3D structure databases

    ProteinModelPortali P98019.
    SMRi P98019. Positions 1-223.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 5405812.
    KEGGi apla:5405812.

    Organism-specific databases

    CTDi 4513.

    Phylogenomic databases

    HOVERGENi HBG012727.
    KOi K02261.

    Family and domain databases

    Gene3Di 1.10.287.90. 1 hit.
    2.60.40.420. 1 hit.
    InterProi IPR001505. Copper_CuA.
    IPR008972. Cupredoxin.
    IPR014222. Cyt_c_oxidase_su2.
    IPR002429. Cyt_c_oxidase_su2_C.
    IPR011759. Cyt_c_oxidase_su2_TM_dom.
    [Graphical view ]
    Pfami PF00116. COX2. 1 hit.
    PF02790. COX2_TM. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49503. SSF49503. 1 hit.
    SSF81464. SSF81464. 1 hit.
    TIGRFAMsi TIGR02866. CoxB. 1 hit.
    PROSITEi PS00078. COX2. 1 hit.
    PS50857. COX2_CUA. 1 hit.
    PS50999. COX2_TM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular characterization and evolution of a duck mitochondrial genome."
      Ramirez V., Savoie P., Morais R.
      J. Mol. Evol. 37:296-310(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Pekin breed.
      Tissue: Liver.
    2. "A gene cytochrome C oxidase subunit II in duck mitochondrial DNA: structural features and sequence evolution."
      Pan Y.F., Lee Y.H.W., Wei Y.H., Chiang A.N.
      Biochem. Int. 30:479-489(1993)
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Pekin breed.
      Tissue: Liver.
    3. "Gene organization of the Peking duck mitochondrial genome."
      Desjardins P., Ramirez V., Morais R.
      Curr. Genet. 17:515-518(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 22-54.
      Strain: Pekin breed.
      Tissue: Liver.

    Entry informationi

    Entry nameiCOX2_ANAPL
    AccessioniPrimary (citable) accession number: P98019
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3