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P98019

- COX2_ANAPL

UniProt

P98019 - COX2_ANAPL

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Protein

Cytochrome c oxidase subunit 2

Gene

MT-CO2

Organism
Anas platyrhynchos (Domestic duck) (Anas boschas)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Cu cationNote: Binds a copper A center.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi160 – 1601Copper ACurated
Metal bindingi195 – 1951Copper ACurated
Metal bindingi199 – 1991Copper ACurated
Metal bindingi203 – 2031Copper ACurated

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. cytochrome-c oxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. electron transport chain Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene namesi
Name:MT-CO2
Synonyms:COII, COXII, MTCO2
Encoded oniMitochondrion
OrganismiAnas platyrhynchos (Domestic duck) (Anas boschas)
Taxonomic identifieri8839 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeAnseriformesAnatidaeAnas
ProteomesiUP000016666: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2626Mitochondrial intermembraneSequence AnalysisAdd
BLAST
Transmembranei27 – 4721HelicalSequence AnalysisAdd
BLAST
Topological domaini48 – 6114Mitochondrial matrixSequence AnalysisAdd
BLAST
Transmembranei62 – 8120HelicalSequence AnalysisAdd
BLAST
Topological domaini82 – 228147Mitochondrial intermembraneSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-KW
  3. respiratory chain complex IV Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 228228Cytochrome c oxidase subunit 2PRO_0000183492Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP98019.
SMRiP98019. Positions 1-223.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG012727.
KOiK02261.

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsiTIGR02866. CoxB. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P98019-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MANHSQLGFQ DASSPIMEEL VEFHDHALIV ALAICSLVLY LLAHMLMEKL
60 70 80 90 100
SSNAVDAQEV ELIWTILPAI VLVLLALPSL QILYMMDEID EPDLTLKAIG
110 120 130 140 150
HQWYWSYEYT DFKDLSFDSY MIPTTDLPNG HFRLLEVDHR VVVPMESPIR
160 170 180 190 200
VIITAGDVLH SWAVPTLGVK TDAIPGRLNQ TSFITTRPGI FYGQCSEICG
210 220
ANHSYMPIVV ESTPLPYFEA WSSLLSSS
Length:228
Mass (Da):25,554
Last modified:October 1, 1996 - v1
Checksum:iE1C4FE82797DBE03
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L22476 Genomic DNA. Translation: AAA72039.1.
X68507 Genomic DNA. Translation: CAA48519.1.
X55531 Genomic DNA. Translation: CAA39147.1.
RefSeqiYP_001382249.1. NC_009684.1.

Genome annotation databases

GeneIDi5405812.
KEGGiapla:5405812.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L22476 Genomic DNA. Translation: AAA72039.1 .
X68507 Genomic DNA. Translation: CAA48519.1 .
X55531 Genomic DNA. Translation: CAA39147.1 .
RefSeqi YP_001382249.1. NC_009684.1.

3D structure databases

ProteinModelPortali P98019.
SMRi P98019. Positions 1-223.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 5405812.
KEGGi apla:5405812.

Organism-specific databases

CTDi 4513.

Phylogenomic databases

HOVERGENi HBG012727.
KOi K02261.

Family and domain databases

Gene3Di 1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProi IPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view ]
Pfami PF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view ]
SUPFAMi SSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsi TIGR02866. CoxB. 1 hit.
PROSITEi PS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular characterization and evolution of a duck mitochondrial genome."
    Ramirez V., Savoie P., Morais R.
    J. Mol. Evol. 37:296-310(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Pekin breed.
    Tissue: Liver.
  2. "A gene cytochrome C oxidase subunit II in duck mitochondrial DNA: structural features and sequence evolution."
    Pan Y.F., Lee Y.H.W., Wei Y.H., Chiang A.N.
    Biochem. Int. 30:479-489(1993)
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Pekin breed.
    Tissue: Liver.
  3. "Gene organization of the Peking duck mitochondrial genome."
    Desjardins P., Ramirez V., Morais R.
    Curr. Genet. 17:515-518(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 22-54.
    Strain: Pekin breed.
    Tissue: Liver.

Entry informationi

Entry nameiCOX2_ANAPL
AccessioniPrimary (citable) accession number: P98019
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 26, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3