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P98012

- COX2_BETVU

UniProt

P98012 - COX2_BETVU

Protein

Cytochrome c oxidase subunit 2

Gene

COX2

Organism
Beta vulgaris (Sugar beet)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    Cofactori

    Copper A.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi187 – 1871Copper ACurated
    Metal bindingi222 – 2221Copper ACurated
    Metal bindingi226 – 2261Copper ACurated
    Metal bindingi230 – 2301Copper ACurated

    GO - Molecular functioni

    1. copper ion binding Source: InterPro
    2. cytochrome-c oxidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. electron transport chain Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    Copper, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome c oxidase polypeptide II
    Gene namesi
    Name:COX2
    Synonyms:COXII
    Encoded oniMitochondrion
    OrganismiBeta vulgaris (Sugar beet)
    Taxonomic identifieri161934 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeCaryophyllalesAmaranthaceaeBeta

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: UniProtKB-SubCell
    3. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 260260Cytochrome c oxidase subunit 2PRO_0000183509Add
    BLAST

    Proteomic databases

    PRIDEiP98012.

    Structurei

    3D structure databases

    ProteinModelPortaliP98012.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4141Mitochondrial intermembraneSequence AnalysisAdd
    BLAST
    Topological domaini59 – 8224Mitochondrial matrixSequence AnalysisAdd
    BLAST
    Topological domaini105 – 260156Mitochondrial intermembraneSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei42 – 5817HelicalSequence AnalysisAdd
    BLAST
    Transmembranei83 – 10422HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Family and domain databases

    Gene3Di1.10.287.90. 1 hit.
    2.60.40.420. 1 hit.
    InterProiIPR001505. Copper_CuA.
    IPR008972. Cupredoxin.
    IPR014222. Cyt_c_oxidase_su2.
    IPR002429. Cyt_c_oxidase_su2_C.
    IPR011759. Cyt_c_oxidase_su2_TM_dom.
    [Graphical view]
    PfamiPF00116. COX2. 1 hit.
    PF02790. COX2_TM. 1 hit.
    [Graphical view]
    SUPFAMiSSF49503. SSF49503. 1 hit.
    SSF81464. SSF81464. 1 hit.
    TIGRFAMsiTIGR02866. CoxB. 1 hit.
    PROSITEiPS00078. COX2. 1 hit.
    PS50857. COX2_CUA. 1 hit.
    PS50999. COX2_TM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P98012-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIVREWLFFT MAPCDAAEPW QLGFQDAATP MMQGIIDLHH DIFFFLILIL    50
    VFVSWILVRA LWHFHYKKNP IPQRIVHGTT IEIIRTIFPS IILMFIAIPS 100
    FALLYSMDEV VVDPAITIKA IGHQWYRSYE YSDYNSSDEQ SLTFDSYTIP 150
    EDDPELGQSR LLEVDNRVVV PAKTHIRIIV TSADVLHSWA VPSSGVKCDA 200
    VPGRLNQTSI LVQREGVYYG QCSEICGTNH AFMPIVVEAV SRKDYGSRVS 250
    NQLIPQTGEA 260
    Length:260
    Mass (Da):29,520
    Last modified:November 1, 1995 - v1
    Checksum:i0AAF70D908A866D8
    GO

    RNA editingi

    Due to conserved RNA editing events, positions 13, 54, 85, 127, 148, 154, 159, 194 and 248 might change.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X55297 Genomic DNA. Translation: CAA39009.1.

    Keywords - Coding sequence diversityi

    RNA editing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X55297 Genomic DNA. Translation: CAA39009.1 .

    3D structure databases

    ProteinModelPortali P98012.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P98012.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 1.10.287.90. 1 hit.
    2.60.40.420. 1 hit.
    InterProi IPR001505. Copper_CuA.
    IPR008972. Cupredoxin.
    IPR014222. Cyt_c_oxidase_su2.
    IPR002429. Cyt_c_oxidase_su2_C.
    IPR011759. Cyt_c_oxidase_su2_TM_dom.
    [Graphical view ]
    Pfami PF00116. COX2. 1 hit.
    PF02790. COX2_TM. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49503. SSF49503. 1 hit.
    SSF81464. SSF81464. 1 hit.
    TIGRFAMsi TIGR02866. CoxB. 1 hit.
    PROSITEi PS00078. COX2. 1 hit.
    PS50857. COX2_CUA. 1 hit.
    PS50999. COX2_TM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The cytochrome oxidase II gene in mitochondria of the sugar-beet Beta vulgaris L."
      Mann V., Ekstein I., Nissen H., Hiser C., McLntosh L., Hirschberg J.
      Plant Mol. Biol. 17:559-566(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: cv. NB-1.
      Tissue: Root.

    Entry informationi

    Entry nameiCOX2_BETVU
    AccessioniPrimary (citable) accession number: P98012
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3