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Protein

Cytochrome c oxidase subunit 2

Gene

COX2

Organism
Beta vulgaris (Sugar beet)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Cu cationNote: Binds a copper A center.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi187Copper ACurated1
Metal bindingi222Copper ACurated1
Metal bindingi226Copper ACurated1
Metal bindingi230Copper ACurated1

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Respiratory chain, Transport
LigandCopper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene namesi
Name:COX2
Synonyms:COXII
Encoded oniMitochondrion
OrganismiBeta vulgaris (Sugar beet)
Taxonomic identifieri161934 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeCaryophyllalesChenopodiaceaeBetoideaeBeta

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 41Mitochondrial intermembraneSequence analysisAdd BLAST41
Transmembranei42 – 58HelicalSequence analysisAdd BLAST17
Topological domaini59 – 82Mitochondrial matrixSequence analysisAdd BLAST24
Transmembranei83 – 104HelicalSequence analysisAdd BLAST22
Topological domaini105 – 260Mitochondrial intermembraneSequence analysisAdd BLAST156

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001835091 – 260Cytochrome c oxidase subunit 2Add BLAST260

Proteomic databases

PRIDEiP98012

Structurei

3D structure databases

ProteinModelPortaliP98012
SMRiP98012
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

CDDicd13912 CcO_II_C, 1 hit
Gene3Di1.10.287.90, 1 hit
2.60.40.420, 1 hit
InterProiView protein in InterPro
IPR002429 CcO_II-like_C
IPR034210 CcO_II_C
IPR001505 Copper_CuA
IPR008972 Cupredoxin
IPR014222 Cyt_c_oxidase_su2
IPR011759 Cyt_c_oxidase_su2_TM_dom
IPR036257 Cyt_c_oxidase_su2_TM_sf
PfamiView protein in Pfam
PF00116 COX2, 1 hit
PF02790 COX2_TM, 1 hit
SUPFAMiSSF49503 SSF49503, 1 hit
SSF81464 SSF81464, 1 hit
TIGRFAMsiTIGR02866 CoxB, 1 hit
PROSITEiView protein in PROSITE
PS00078 COX2, 1 hit
PS50857 COX2_CUA, 1 hit
PS50999 COX2_TM, 1 hit

Sequencei

Sequence statusi: Complete.

P98012-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIVREWLFFT MAPCDAAEPW QLGFQDAATP MMQGIIDLHH DIFFFLILIL
60 70 80 90 100
VFVSWILVRA LWHFHYKKNP IPQRIVHGTT IEIIRTIFPS IILMFIAIPS
110 120 130 140 150
FALLYSMDEV VVDPAITIKA IGHQWYRSYE YSDYNSSDEQ SLTFDSYTIP
160 170 180 190 200
EDDPELGQSR LLEVDNRVVV PAKTHIRIIV TSADVLHSWA VPSSGVKCDA
210 220 230 240 250
VPGRLNQTSI LVQREGVYYG QCSEICGTNH AFMPIVVEAV SRKDYGSRVS
260
NQLIPQTGEA
Length:260
Mass (Da):29,520
Last modified:November 1, 1995 - v1
Checksum:i0AAF70D908A866D8
GO

RNA editingi

Due to conserved RNA editing events, positions 13, 54, 85, 127, 148, 154, 159, 194 and 248 might change.1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55297 Genomic DNA Translation: CAA39009.1

Keywords - Coding sequence diversityi

RNA editing

Similar proteinsi

Entry informationi

Entry nameiCOX2_BETVU
AccessioniPrimary (citable) accession number: P98012
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: March 28, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health