P98012 (COX2_BETVU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome c oxidase subunit 2
EC=1.9.3.1

Alternative name(s):
Cytochrome c oxidase polypeptide II

Gene names

Name:	COX2
Synonyms:	COXII

Encoded on

Mitochondrion

Organism

Beta vulgaris (Sugar beet)

Taxonomic identifier

161934 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › Caryophyllales › Amaranthaceae › Beta

Protein attributes

Sequence length	260 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.
Catalytic activity	4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.
Cofactor	Copper A.
Subcellular location	Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the cytochrome c oxidase subunit 2 family.
RNA editing	Due to conserved RNA editing events, positions 13, 54, 85, 127, 148, 154, 159, 194 and 248 might change.

Ontologies

Keywords
Biological process	Electron transport Respiratory chain Transport
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Coding sequence diversity	RNA editing
Domain	Transmembrane Transmembrane helix
Ligand	Copper Metal-binding
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological_process	electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-SubCell respiratory chain Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	copper ion binding Inferred from electronic annotation. Source: InterPro cytochrome-c oxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 260	260	Cytochrome c oxidase subunit 2		PRO_0000183509
Regions
	Topological domain	1 – 41	41	Mitochondrial intermembrane Potential
	Transmembrane	42 – 58	17	Helical; Potential
	Topological domain	59 – 82	24	Mitochondrial matrix Potential
	Transmembrane	83 – 104	22	Helical; Potential
	Topological domain	105 – 260	156	Mitochondrial intermembrane Potential
Sites
	Metal binding	187	1	Copper A Probable
	Metal binding	222	1	Copper A Probable
	Metal binding	226	1	Copper A Probable
	Metal binding	230	1	Copper A Probable

Sequences

	Sequence		Length	Mass (Da)
	P98012 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: 0AAF70D908A866D8	FASTA	260	29,520
	10 20 30 40 50 60 MIVREWLFFT MAPCDAAEPW QLGFQDAATP MMQGIIDLHH DIFFFLILIL VFVSWILVRA 70 80 90 100 110 120 LWHFHYKKNP IPQRIVHGTT IEIIRTIFPS IILMFIAIPS FALLYSMDEV VVDPAITIKA 130 140 150 160 170 180 IGHQWYRSYE YSDYNSSDEQ SLTFDSYTIP EDDPELGQSR LLEVDNRVVV PAKTHIRIIV 190 200 210 220 230 240 TSADVLHSWA VPSSGVKCDA VPGRLNQTSI LVQREGVYYG QCSEICGTNH AFMPIVVEAV 250 260 SRKDYGSRVS NQLIPQTGEA

References

[1]	"The cytochrome oxidase II gene in mitochondria of the sugar-beet Beta vulgaris L." Mann V., Ekstein I., Nissen H., Hiser C., McLntosh L., Hirschberg J. Plant Mol. Biol. 17:559-566(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: cv. NB-1. Tissue: Root.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X55297 Genomic DNA. Translation: CAA39009.1.
3D structure databases
ProteinModelPortal	P98012.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	1.10.287.90. 1 hit. 2.60.40.420. 1 hit.
InterPro	IPR001505. Copper_CuA. IPR008972. Cupredoxin. IPR014222. Cyt_c_oxidase_su2. IPR002429. Cyt_c_oxidase_su2_C. IPR011759. Cyt_c_oxidase_su2_TM_dom. [Graphical view]
Pfam	PF00116. COX2. 1 hit. PF02790. COX2_TM. 1 hit. [Graphical view]
SUPFAM	SSF49503. Cupredoxin. 1 hit. SSF81464. Cyt_c_oxidase_II-like_TM. 1 hit.
TIGRFAMs	TIGR02866. CoxB. 1 hit.
PROSITE	PS00078. COX2. 1 hit. PS50857. COX2_CUA. 1 hit. PS50999. COX2_TM. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

COX2_BETVU

Accession

Primary (citable) accession number: P98012

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	May 1, 2013
This is version 83 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program