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P98012 (COX2_BETVU) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 2

EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene names
Name:COX2
Synonyms:COXII
Encoded onMitochondrion
OrganismBeta vulgaris (Sugar beet)
Taxonomic identifier161934 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeCaryophyllalesAmaranthaceaeBeta

Protein attributes

Sequence length260 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactor

Copper A.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 2 family.

RNA editing

Due to conserved RNA editing events, positions 13, 54, 85, 127, 148, 154, 159, 194 and 248 might change.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 260260Cytochrome c oxidase subunit 2
PRO_0000183509

Regions

Topological domain1 – 4141Mitochondrial intermembrane Potential
Transmembrane42 – 5817Helical; Potential
Topological domain59 – 8224Mitochondrial matrix Potential
Transmembrane83 – 10422Helical; Potential
Topological domain105 – 260156Mitochondrial intermembrane Potential

Sites

Metal binding1871Copper A Probable
Metal binding2221Copper A Probable
Metal binding2261Copper A Probable
Metal binding2301Copper A Probable

Sequences

Sequence LengthMass (Da)Tools
P98012 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 0AAF70D908A866D8

FASTA26029,520
        10         20         30         40         50         60 
MIVREWLFFT MAPCDAAEPW QLGFQDAATP MMQGIIDLHH DIFFFLILIL VFVSWILVRA 

        70         80         90        100        110        120 
LWHFHYKKNP IPQRIVHGTT IEIIRTIFPS IILMFIAIPS FALLYSMDEV VVDPAITIKA 

       130        140        150        160        170        180 
IGHQWYRSYE YSDYNSSDEQ SLTFDSYTIP EDDPELGQSR LLEVDNRVVV PAKTHIRIIV 

       190        200        210        220        230        240 
TSADVLHSWA VPSSGVKCDA VPGRLNQTSI LVQREGVYYG QCSEICGTNH AFMPIVVEAV 

       250        260 
SRKDYGSRVS NQLIPQTGEA 

« Hide

References

[1]"The cytochrome oxidase II gene in mitochondria of the sugar-beet Beta vulgaris L."
Mann V., Ekstein I., Nissen H., Hiser C., McLntosh L., Hirschberg J.
Plant Mol. Biol. 17:559-566(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: cv. NB-1.
Tissue: Root.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X55297 Genomic DNA. Translation: CAA39009.1.

3D structure databases

ProteinModelPortalP98012.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEP98012.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsTIGR02866. CoxB. 1 hit.
PROSITEPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX2_BETVU
AccessionPrimary (citable) accession number: P98012
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 16, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families