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P98012

- COX2_BETVU

UniProt

P98012 - COX2_BETVU

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Protein

Cytochrome c oxidase subunit 2

Gene

COX2

Organism
Beta vulgaris (Sugar beet)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Copper A.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi187 – 1871Copper ACurated
Metal bindingi222 – 2221Copper ACurated
Metal bindingi226 – 2261Copper ACurated
Metal bindingi230 – 2301Copper ACurated

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. cytochrome-c oxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. electron transport chain Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene namesi
Name:COX2
Synonyms:COXII
Encoded oniMitochondrion
OrganismiBeta vulgaris (Sugar beet)
Taxonomic identifieri161934 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeCaryophyllalesAmaranthaceaeBeta

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-KW
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 260260Cytochrome c oxidase subunit 2PRO_0000183509Add
BLAST

Proteomic databases

PRIDEiP98012.

Structurei

3D structure databases

ProteinModelPortaliP98012.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4141Mitochondrial intermembraneSequence AnalysisAdd
BLAST
Topological domaini59 – 8224Mitochondrial matrixSequence AnalysisAdd
BLAST
Topological domaini105 – 260156Mitochondrial intermembraneSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei42 – 5817HelicalSequence AnalysisAdd
BLAST
Transmembranei83 – 10422HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsiTIGR02866. CoxB. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P98012-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIVREWLFFT MAPCDAAEPW QLGFQDAATP MMQGIIDLHH DIFFFLILIL
60 70 80 90 100
VFVSWILVRA LWHFHYKKNP IPQRIVHGTT IEIIRTIFPS IILMFIAIPS
110 120 130 140 150
FALLYSMDEV VVDPAITIKA IGHQWYRSYE YSDYNSSDEQ SLTFDSYTIP
160 170 180 190 200
EDDPELGQSR LLEVDNRVVV PAKTHIRIIV TSADVLHSWA VPSSGVKCDA
210 220 230 240 250
VPGRLNQTSI LVQREGVYYG QCSEICGTNH AFMPIVVEAV SRKDYGSRVS
260
NQLIPQTGEA
Length:260
Mass (Da):29,520
Last modified:November 1, 1995 - v1
Checksum:i0AAF70D908A866D8
GO

RNA editingi

Due to conserved RNA editing events, positions 13, 54, 85, 127, 148, 154, 159, 194 and 248 might change.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X55297 Genomic DNA. Translation: CAA39009.1.

Keywords - Coding sequence diversityi

RNA editing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X55297 Genomic DNA. Translation: CAA39009.1 .

3D structure databases

ProteinModelPortali P98012.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P98012.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProi IPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view ]
Pfami PF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view ]
SUPFAMi SSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsi TIGR02866. CoxB. 1 hit.
PROSITEi PS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The cytochrome oxidase II gene in mitochondria of the sugar-beet Beta vulgaris L."
    Mann V., Ekstein I., Nissen H., Hiser C., McLntosh L., Hirschberg J.
    Plant Mol. Biol. 17:559-566(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: cv. NB-1.
    Tissue: Root.

Entry informationi

Entry nameiCOX2_BETVU
AccessioniPrimary (citable) accession number: P98012
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 29, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3