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P98005

- COX13_THET8

UniProt

P98005 - COX13_THET8

Protein

Cytochrome c oxidase polypeptide I+III

Gene

caaA

Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Co I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme a of subunit 1 to the bimetallic center formed by heme a3 and copper B. This cytochrome c oxidase shows proton pump activity across the membrane in addition to the electron transfer.

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    Cofactori

    Binds 1 copper B ion per subunit.
    Binds 2 heme groups per subunit.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi73 – 731Iron (heme A axial ligand)Curated
    Metal bindingi250 – 2501Copper B
    Metal bindingi254 – 2541Copper B
    Metal bindingi299 – 2991Copper BCurated
    Metal bindingi300 – 3001Copper BCurated
    Metal bindingi385 – 3851Iron (heme A3 axial ligand)Curated
    Metal bindingi387 – 3871Iron (heme A axial ligand)Curated

    GO - Molecular functioni

    1. copper ion binding Source: InterPro
    2. cytochrome-c oxidase activity Source: UniProtKB-EC
    3. heme binding Source: InterPro
    4. iron ion binding Source: InterPro

    GO - Biological processi

    1. aerobic respiration Source: InterPro
    2. oxidative phosphorylation Source: UniProtKB-UniPathway
    3. respiratory electron transport chain Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Hydrogen ion transport, Ion transport, Respiratory chain, Transport

    Keywords - Ligandi

    Copper, Heme, Iron, Metal-binding

    Enzyme and pathway databases

    BioCyciTTHE300852:GH8R-326-MONOMER.
    UniPathwayiUPA00705.

    Protein family/group databases

    TCDBi3.D.4.4.3. the proton-translocating cytochrome oxidase (cox) superfamily.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase polypeptide I+III (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome c aa(3) subunit 1
    Short name:
    A-protein
    Short name:
    Cytochrome caa3
    Gene namesi
    Name:caaA
    Synonyms:ctaD
    Ordered Locus Names:TTHA0312
    OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
    Taxonomic identifieri300852 [NCBI]
    Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
    ProteomesiUP000000532: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell
    3. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 791791Cytochrome c oxidase polypeptide I+IIIPRO_0000183464Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Cross-linki250 ↔ 2541'-histidyl-3'-tyrosine (His-Tyr)By similarity

    Interactioni

    Subunit structurei

    Possibly a heterodimer of A-protein (contains: cytochrome c oxidase subunits I and III) and subunit II. The A-protein could also present a precursor form of subunits I and III.

    Protein-protein interaction databases

    DIPiDIP-59901N.
    STRINGi300852.TTHA0312.

    Structurei

    Secondary structure

    1
    791
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi13 – 208
    Helixi24 – 5229
    Helixi63 – 8018
    Helixi82 – 854
    Turni86 – 883
    Helixi89 – 9911
    Helixi107 – 12620
    Helixi127 – 1293
    Turni138 – 1414
    Helixi145 – 1484
    Helixi153 – 18028
    Helixi188 – 1903
    Helixi193 – 20816
    Helixi210 – 22516
    Helixi232 – 2343
    Helixi238 – 24912
    Helixi251 – 27222
    Helixi279 – 29214
    Helixi297 – 3004
    Helixi308 – 32013
    Helixi322 – 33615
    Helixi345 – 36824
    Helixi370 – 3767
    Helixi380 – 39011
    Turni391 – 3933
    Helixi394 – 41017
    Helixi416 – 44227
    Beta strandi446 – 4483
    Beta strandi454 – 4563
    Helixi459 – 49032
    Helixi504 – 5074
    Beta strandi526 – 5283
    Helixi530 – 5367
    Helixi546 – 5483
    Helixi557 – 57418
    Helixi580 – 59718
    Beta strandi611 – 6144
    Helixi616 – 64429
    Helixi657 – 68327
    Helixi686 – 71530
    Turni720 – 7223
    Helixi724 – 75633
    Helixi765 – 78824

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2YEVX-ray2.36A/D1-791[»]
    ProteinModelPortaliP98005.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei29 – 4921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei78 – 9821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei111 – 13121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei155 – 17521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei201 – 22121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei244 – 26421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei282 – 30221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei312 – 33221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei347 – 36721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei381 – 40121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei423 – 44321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei464 – 48421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei566 – 58621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei617 – 63721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei657 – 67721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei691 – 71121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei729 – 74921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei771 – 79121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 473473COX1Add
    BLAST
    Regioni545 – 791247COX3Add
    BLAST

    Sequence similaritiesi

    In the N-terminal section; belongs to the heme-copper respiratory oxidase family.Curated
    In the C-terminal section; belongs to the cytochrome c oxidase subunit 3 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0843.
    HOGENOMiHOG000085274.
    KOiK15408.
    OMAiMGMTRRV.
    OrthoDBiEOG6B35XR.
    PhylomeDBiP98005.

    Family and domain databases

    Gene3Di1.20.120.80. 1 hit.
    1.20.210.10. 1 hit.
    InterProiIPR000883. COX1.
    IPR023615. Cyt_c_Oxase_su1_BS.
    IPR023616. Cyt_c_Oxase_su1_dom.
    IPR014241. Cyt_c_oxidase_su1_bac.
    IPR013833. Cyt_c_oxidase_su3_a-hlx.
    IPR000298. Cyt_c_oxidase_su3_dom.
    [Graphical view]
    PANTHERiPTHR10422. PTHR10422. 1 hit.
    PfamiPF00115. COX1. 1 hit.
    PF00510. COX3. 1 hit.
    [Graphical view]
    PRINTSiPR01165. CYCOXIDASEI.
    SUPFAMiSSF81442. SSF81442. 1 hit.
    SSF81452. SSF81452. 1 hit.
    TIGRFAMsiTIGR02891. CtaD_CoxA. 1 hit.
    PROSITEiPS50855. COX1. 1 hit.
    PS00077. COX1_CUB. 1 hit.
    PS50253. COX3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P98005-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAITAKPKAG VWAVLWDLLT TVDHKKIGLM YTATAFFAFA LAGVFSLLIR    50
    TQLAVPNNQF LTGEQYNQIL TLHGATMLFF FIIQAGLTGF GNFVVPLMLG 100
    ARDVALPRVN AFSYWAFLGA IVLALMSYFF PGGAPSVGWT FYYPFSAQSE 150
    SGVDFYLAAI LLLGFSSLLG NANFVATIYN LRAQGMSLWK MPIYVWSVFA 200
    ASVLNLFSLA GLTAATLLVL LERKIGLSWF NPAVGGDPVL FQQFFWFYSH 250
    PTVYVMLLPY LGILAEVAST FARKPLFGYR QMVWAQMGIV VLGTMVWAHH 300
    MFTVGESTLF QIAFAFFTAL IAVPTGVKLF NIIGTLWGGK LQMKTPLYWV 350
    LGFIFNFLLG GITGVMLSMT PLDYQFHDSY FVVAHFHNVL MAGSGFGAFA 400
    GLYYWWPKMT GRMYDERLGR LHFWLFLVGY LLTFLPQYAL GYLGMPRRYY 450
    TYNADIAGWP ELNLLSTIGA YILGLGGLVW IYTMWKSLRS GPKAPDNPWG 500
    GYTLEWLTAS PPKAHNFDVK LPTEFPSERP LYDWKKKGVE LKPEDPAHIH 550
    LPNSSFWPFY SAATLFAFFV AVAALPVPNV WMWVFLALFA YGLVRWALED 600
    EYSHPVEHHT VTGKSNAWMG MAWFIVSEVG LFAILIAGYL YLRLSGAATP 650
    PEERPALWLA LLNTFLLVSS SFTVHFAHHD LRRGRFNPFR FGLLVTIILG 700
    VLFFLVQSWE FYQFYHHSSW QENLWTAAFF TIVGLHGLHV VIGGFGLILA 750
    YLQALRGKIT LHNHGTLEAA SMYWHLVDAV WLVIVTIFYV W 791
    Length:791
    Mass (Da):89,214
    Last modified:February 1, 1996 - v1
    Checksum:iF4DCF3E8AFF07606
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M84341 Genomic DNA. Translation: AAA27485.1.
    AP008226 Genomic DNA. Translation: BAD70135.1.
    PIRiA46616.
    RefSeqiWP_011227851.1. NC_006461.1.
    YP_143578.1. NC_006461.1.

    Genome annotation databases

    EnsemblBacteriaiBAD70135; BAD70135; BAD70135.
    GeneIDi3168081.
    KEGGittj:TTHA0312.
    PATRICi23955580. VBITheThe93045_0312.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M84341 Genomic DNA. Translation: AAA27485.1 .
    AP008226 Genomic DNA. Translation: BAD70135.1 .
    PIRi A46616.
    RefSeqi WP_011227851.1. NC_006461.1.
    YP_143578.1. NC_006461.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2YEV X-ray 2.36 A/D 1-791 [» ]
    ProteinModelPortali P98005.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-59901N.
    STRINGi 300852.TTHA0312.

    Protein family/group databases

    TCDBi 3.D.4.4.3. the proton-translocating cytochrome oxidase (cox) superfamily.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAD70135 ; BAD70135 ; BAD70135 .
    GeneIDi 3168081.
    KEGGi ttj:TTHA0312.
    PATRICi 23955580. VBITheThe93045_0312.

    Phylogenomic databases

    eggNOGi COG0843.
    HOGENOMi HOG000085274.
    KOi K15408.
    OMAi MGMTRRV.
    OrthoDBi EOG6B35XR.
    PhylomeDBi P98005.

    Enzyme and pathway databases

    UniPathwayi UPA00705 .
    BioCyci TTHE300852:GH8R-326-MONOMER.

    Family and domain databases

    Gene3Di 1.20.120.80. 1 hit.
    1.20.210.10. 1 hit.
    InterProi IPR000883. COX1.
    IPR023615. Cyt_c_Oxase_su1_BS.
    IPR023616. Cyt_c_Oxase_su1_dom.
    IPR014241. Cyt_c_oxidase_su1_bac.
    IPR013833. Cyt_c_oxidase_su3_a-hlx.
    IPR000298. Cyt_c_oxidase_su3_dom.
    [Graphical view ]
    PANTHERi PTHR10422. PTHR10422. 1 hit.
    Pfami PF00115. COX1. 1 hit.
    PF00510. COX3. 1 hit.
    [Graphical view ]
    PRINTSi PR01165. CYCOXIDASEI.
    SUPFAMi SSF81442. SSF81442. 1 hit.
    SSF81452. SSF81452. 1 hit.
    TIGRFAMsi TIGR02891. CtaD_CoxA. 1 hit.
    PROSITEi PS50855. COX1. 1 hit.
    PS00077. COX1_CUB. 1 hit.
    PS50253. COX3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cytochrome oxidase genes from Thermus thermophilus. Nucleotide sequence of the fused gene and analysis of the deduced primary structures for subunits I and III of cytochrome caa3."
      Mather M.W., Springer P., Hensel S., Buse G., Fee J.A.
      J. Biol. Chem. 268:5395-5408(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Complete genome sequence of Thermus thermophilus HB8."
      Masui R., Kurokawa K., Nakagawa N., Tokunaga F., Koyama Y., Shibata T., Oshima T., Yokoyama S., Yasunaga T., Kuramitsu S.
      Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: HB8 / ATCC 27634 / DSM 579.
    3. "Evidence for a copper-coordinated histidine-tyrosine cross-link in the active site of cytochrome oxidase."
      Buse G., Soulimane T., Dewor M., Meyer H.E., Blueggel M.
      Protein Sci. 8:985-990(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: COVALENT BOND.

    Entry informationi

    Entry nameiCOX13_THET8
    AccessioniPrimary (citable) accession number: P98005
    Secondary accession number(s): Q5SLI1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 116 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3