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Protein

Cytochrome c oxidase polypeptide I+III

Gene

caaA

Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Co I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme a of subunit 1 to the bimetallic center formed by heme a3 and copper B. This cytochrome c oxidase shows proton pump activity across the membrane in addition to the electron transfer.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Protein has several cofactor binding sites:
  • Cu2+Note: Binds 1 copper B ion per subunit.
  • hemeNote: Binds 2 heme groups per subunit.

Pathwayi: oxidative phosphorylation

This protein is involved in the pathway oxidative phosphorylation, which is part of Energy metabolism.
View all proteins of this organism that are known to be involved in the pathway oxidative phosphorylation and in Energy metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi73Iron (heme A axial ligand)Curated1
Metal bindingi250Copper B1
Metal bindingi254Copper B1
Metal bindingi299Copper BCurated1
Metal bindingi300Copper BCurated1
Metal bindingi385Iron (heme A3 axial ligand)Curated1
Metal bindingi387Iron (heme A axial ligand)Curated1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Hydrogen ion transport, Ion transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

BRENDAi1.9.3.1. 2305.
UniPathwayiUPA00705.

Protein family/group databases

TCDBi3.D.4.4.3. the proton-translocating cytochrome oxidase (cox) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase polypeptide I+III (EC:1.9.3.1)
Alternative name(s):
Cytochrome c aa(3) subunit 1
Short name:
A-protein
Short name:
Cytochrome caa3
Gene namesi
Name:caaA
Synonyms:ctaD
Ordered Locus Names:TTHA0312
OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Taxonomic identifieri300852 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
Proteomesi
  • UP000000532 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei29 – 49HelicalSequence analysisAdd BLAST21
Transmembranei78 – 98HelicalSequence analysisAdd BLAST21
Transmembranei111 – 131HelicalSequence analysisAdd BLAST21
Transmembranei155 – 175HelicalSequence analysisAdd BLAST21
Transmembranei201 – 221HelicalSequence analysisAdd BLAST21
Transmembranei244 – 264HelicalSequence analysisAdd BLAST21
Transmembranei282 – 302HelicalSequence analysisAdd BLAST21
Transmembranei312 – 332HelicalSequence analysisAdd BLAST21
Transmembranei347 – 367HelicalSequence analysisAdd BLAST21
Transmembranei381 – 401HelicalSequence analysisAdd BLAST21
Transmembranei423 – 443HelicalSequence analysisAdd BLAST21
Transmembranei464 – 484HelicalSequence analysisAdd BLAST21
Transmembranei566 – 586HelicalSequence analysisAdd BLAST21
Transmembranei617 – 637HelicalSequence analysisAdd BLAST21
Transmembranei657 – 677HelicalSequence analysisAdd BLAST21
Transmembranei691 – 711HelicalSequence analysisAdd BLAST21
Transmembranei729 – 749HelicalSequence analysisAdd BLAST21
Transmembranei771 – 791HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001834641 – 791Cytochrome c oxidase polypeptide I+IIIAdd BLAST791

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki250 ↔ 2541'-histidyl-3'-tyrosine (His-Tyr)By similarity

Interactioni

Subunit structurei

Possibly a heterodimer of A-protein (contains: cytochrome c oxidase subunits I and III) and subunit II. The A-protein could also present a precursor form of subunits I and III.

Protein-protein interaction databases

DIPiDIP-59901N.
STRINGi300852.TTHA0312.

Structurei

Secondary structure

1791
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi13 – 20Combined sources8
Helixi24 – 52Combined sources29
Helixi63 – 80Combined sources18
Helixi82 – 85Combined sources4
Turni86 – 88Combined sources3
Helixi89 – 99Combined sources11
Helixi107 – 126Combined sources20
Helixi127 – 129Combined sources3
Turni138 – 141Combined sources4
Helixi145 – 148Combined sources4
Helixi153 – 180Combined sources28
Helixi188 – 190Combined sources3
Helixi193 – 208Combined sources16
Helixi210 – 225Combined sources16
Helixi232 – 234Combined sources3
Helixi238 – 249Combined sources12
Helixi251 – 272Combined sources22
Helixi279 – 292Combined sources14
Helixi297 – 300Combined sources4
Helixi308 – 320Combined sources13
Helixi322 – 336Combined sources15
Helixi345 – 368Combined sources24
Helixi370 – 376Combined sources7
Helixi380 – 390Combined sources11
Turni391 – 393Combined sources3
Helixi394 – 410Combined sources17
Helixi416 – 442Combined sources27
Beta strandi446 – 448Combined sources3
Beta strandi454 – 456Combined sources3
Helixi459 – 490Combined sources32
Helixi504 – 507Combined sources4
Beta strandi526 – 528Combined sources3
Helixi530 – 536Combined sources7
Helixi546 – 548Combined sources3
Helixi557 – 574Combined sources18
Helixi580 – 597Combined sources18
Beta strandi611 – 614Combined sources4
Helixi616 – 644Combined sources29
Helixi657 – 683Combined sources27
Helixi686 – 715Combined sources30
Turni720 – 722Combined sources3
Helixi724 – 756Combined sources33
Helixi765 – 788Combined sources24

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2YEVX-ray2.36A/D1-791[»]
ProteinModelPortaliP98005.
SMRiP98005.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 473COX1Add BLAST473
Regioni545 – 791COX3Add BLAST247

Sequence similaritiesi

In the N-terminal section; belongs to the heme-copper respiratory oxidase family.Curated
In the C-terminal section; belongs to the cytochrome c oxidase subunit 3 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105BZ9. Bacteria.
COG0843. LUCA.
COG1845. LUCA.
HOGENOMiHOG000085274.
KOiK15408.
OMAiPYHTFEE.
PhylomeDBiP98005.

Family and domain databases

Gene3Di1.20.120.80. 1 hit.
1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023616. Cyt_c_oxase-like_su1_dom.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR000298. Cyt_c_oxidase-like_su3.
IPR014241. Cyt_c_oxidase_su1_bac.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
PF00510. COX3. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
SSF81452. SSF81452. 1 hit.
TIGRFAMsiTIGR02891. CtaD_CoxA. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
PS50253. COX3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P98005-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAITAKPKAG VWAVLWDLLT TVDHKKIGLM YTATAFFAFA LAGVFSLLIR
60 70 80 90 100
TQLAVPNNQF LTGEQYNQIL TLHGATMLFF FIIQAGLTGF GNFVVPLMLG
110 120 130 140 150
ARDVALPRVN AFSYWAFLGA IVLALMSYFF PGGAPSVGWT FYYPFSAQSE
160 170 180 190 200
SGVDFYLAAI LLLGFSSLLG NANFVATIYN LRAQGMSLWK MPIYVWSVFA
210 220 230 240 250
ASVLNLFSLA GLTAATLLVL LERKIGLSWF NPAVGGDPVL FQQFFWFYSH
260 270 280 290 300
PTVYVMLLPY LGILAEVAST FARKPLFGYR QMVWAQMGIV VLGTMVWAHH
310 320 330 340 350
MFTVGESTLF QIAFAFFTAL IAVPTGVKLF NIIGTLWGGK LQMKTPLYWV
360 370 380 390 400
LGFIFNFLLG GITGVMLSMT PLDYQFHDSY FVVAHFHNVL MAGSGFGAFA
410 420 430 440 450
GLYYWWPKMT GRMYDERLGR LHFWLFLVGY LLTFLPQYAL GYLGMPRRYY
460 470 480 490 500
TYNADIAGWP ELNLLSTIGA YILGLGGLVW IYTMWKSLRS GPKAPDNPWG
510 520 530 540 550
GYTLEWLTAS PPKAHNFDVK LPTEFPSERP LYDWKKKGVE LKPEDPAHIH
560 570 580 590 600
LPNSSFWPFY SAATLFAFFV AVAALPVPNV WMWVFLALFA YGLVRWALED
610 620 630 640 650
EYSHPVEHHT VTGKSNAWMG MAWFIVSEVG LFAILIAGYL YLRLSGAATP
660 670 680 690 700
PEERPALWLA LLNTFLLVSS SFTVHFAHHD LRRGRFNPFR FGLLVTIILG
710 720 730 740 750
VLFFLVQSWE FYQFYHHSSW QENLWTAAFF TIVGLHGLHV VIGGFGLILA
760 770 780 790
YLQALRGKIT LHNHGTLEAA SMYWHLVDAV WLVIVTIFYV W
Length:791
Mass (Da):89,214
Last modified:February 1, 1996 - v1
Checksum:iF4DCF3E8AFF07606
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M84341 Genomic DNA. Translation: AAA27485.1.
AP008226 Genomic DNA. Translation: BAD70135.1.
PIRiA46616.
RefSeqiWP_011227851.1. NC_006461.1.
YP_143578.1. NC_006461.1.

Genome annotation databases

EnsemblBacteriaiBAD70135; BAD70135; BAD70135.
GeneIDi3168081.
KEGGittj:TTHA0312.
PATRICi23955580. VBITheThe93045_0312.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M84341 Genomic DNA. Translation: AAA27485.1.
AP008226 Genomic DNA. Translation: BAD70135.1.
PIRiA46616.
RefSeqiWP_011227851.1. NC_006461.1.
YP_143578.1. NC_006461.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2YEVX-ray2.36A/D1-791[»]
ProteinModelPortaliP98005.
SMRiP98005.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-59901N.
STRINGi300852.TTHA0312.

Protein family/group databases

TCDBi3.D.4.4.3. the proton-translocating cytochrome oxidase (cox) superfamily.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAD70135; BAD70135; BAD70135.
GeneIDi3168081.
KEGGittj:TTHA0312.
PATRICi23955580. VBITheThe93045_0312.

Phylogenomic databases

eggNOGiENOG4105BZ9. Bacteria.
COG0843. LUCA.
COG1845. LUCA.
HOGENOMiHOG000085274.
KOiK15408.
OMAiPYHTFEE.
PhylomeDBiP98005.

Enzyme and pathway databases

UniPathwayiUPA00705.
BRENDAi1.9.3.1. 2305.

Family and domain databases

Gene3Di1.20.120.80. 1 hit.
1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023616. Cyt_c_oxase-like_su1_dom.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR000298. Cyt_c_oxidase-like_su3.
IPR014241. Cyt_c_oxidase_su1_bac.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
PF00510. COX3. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
SSF81452. SSF81452. 1 hit.
TIGRFAMsiTIGR02891. CtaD_CoxA. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
PS50253. COX3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCOX13_THET8
AccessioniPrimary (citable) accession number: P98005
Secondary accession number(s): Q5SLI1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 30, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.