Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P98003 (COX1_CRION) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 1

EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene names
Name:COI
Encoded onMitochondrion
OrganismCrithidia oncopelti
Taxonomic identifier5657 [NCBI]
Taxonomic lineageEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeStrigomonas

Protein attributes

Sequence length340 AA.
Sequence statusFragment.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathway

Energy metabolism; oxidative phosphorylation.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – ›340›340Cytochrome c oxidase subunit 1
PRO_0000183317

Regions

Transmembrane18 – 3821Helical; Potential
Transmembrane42 – 6221Helical; Potential
Transmembrane66 – 8621Helical; Potential
Transmembrane100 – 12021Helical; Potential
Transmembrane148 – 16821Helical; Potential
Transmembrane186 – 20621Helical; Potential
Transmembrane237 – 25721Helical; Potential
Transmembrane279 – 29921Helical; Potential
Transmembrane305 – 32521Helical; Potential

Sites

Metal binding641Iron (heme A axial ligand) Probable
Metal binding2431Copper B Probable
Metal binding2471Copper B Probable
Metal binding2921Copper B Probable
Metal binding2931Copper B Probable

Amino acid modifications

Cross-link243 ↔ 2471'-histidyl-3'-tyrosine (His-Tyr) By similarity

Experimental info

Non-terminal residue3401

Sequences

Sequence LengthMass (Da)Tools
P98003 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: 65D78B06AFD07B54

FASTA34038,174
        10         20         30         40         50         60 
MFWISLVCLS VSHKMIGMCY LLVAILCGFL GYIYSLFIRL ELSIIGCGVL FGDYQYYNVL 

        70         80         90        100        110        120 
VTTHGLVMVF AFIMPVMMGG LVNYFVPVLS GFPDMVFPRL NNMSFWMFMG GFGALVSGLL 

       130        140        150        160        170        180 
TEEGMGIGWT MYPTLICVDF HSSLACDFTV FAVHLLGVSS ILNSINLLGT LFCCRRKFFS 

       190        200        210        220        230        240 
FLNWTLFIWG SLITALLLII TLPVLAGGVT LVLCDRNFNT SFYDVVGGGD LLLFQHLFWF 

       250        260        270        280        290        300 
FGHPEVYIII IPVFGLISTM VEVLGFRCVF SSVAMIYSMI LIAILGFFVW AHHMFVVGMD 

       310        320        330        340 
VDTRAYFGSV TVLIGLPTCI KLFNWTYSFL YTDFIIAFEA 

« Hide

References

[1]Maslov D.A., Horvath A., Gwang K. II, Kolesnikov A.A.
Submitted (OCT-1990) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: S-068.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X56015 Genomic DNA. Translation: CAA39490.1.
PIRS34958.

3D structure databases

ProteinModelPortalP98003.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00705.

Family and domain databases

Gene3D1.20.210.10. 1 hit.
InterProIPR000883. Cyt_c_Oxase_su1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERPTHR10422. PTHR10422. 1 hit.
PfamPF00115. COX1. 1 hit.
[Graphical view]
PRINTSPR01165. CYCOXIDASEI.
SUPFAMSSF81442. SSF81442. 1 hit.
PROSITEPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX1_CRION
AccessionPrimary (citable) accession number: P98003
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: April 16, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways