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P98001 (COX1_SACDO) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 1

EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene names
Name:COXI
Encoded onMitochondrion
OrganismSaccharomyces douglasii (Yeast)
Taxonomic identifier46617 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length534 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathway

Energy metabolism; oxidative phosphorylation.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 534534Cytochrome c oxidase subunit 1
PRO_0000183410

Regions

Transmembrane16 – 3621Helical; Potential
Transmembrane57 – 7721Helical; Potential
Transmembrane101 – 12121Helical; Potential
Transmembrane147 – 16721Helical; Potential
Transmembrane182 – 20221Helical; Potential
Transmembrane235 – 25521Helical; Potential
Transmembrane267 – 28721Helical; Potential
Transmembrane310 – 33021Helical; Potential
Transmembrane338 – 35821Helical; Potential
Transmembrane372 – 39221Helical; Potential
Transmembrane414 – 43421Helical; Potential
Transmembrane452 – 47221Helical; Potential

Sites

Metal binding621Iron (heme A axial ligand) Probable
Metal binding2411Copper B Probable
Metal binding2451Copper B Probable
Metal binding2901Copper B Probable
Metal binding2911Copper B Probable

Amino acid modifications

Cross-link241 ↔ 2451'-histidyl-3'-tyrosine (His-Tyr) By similarity

Sequences

Sequence LengthMass (Da)Tools
P98001 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: C0FCB33390B31539

FASTA53458,747
        10         20         30         40         50         60 
MVQRWLYSTN AKDIAVLYFM LAIFSGMAGT AMSLIIRLEL AAPGSQYLQG NAQLFNVLVV 

        70         80         90        100        110        120 
GHAVLMIFFL VMPALIGGFG NYLLPLMIGA TDTAFPRINN IAFWVLPMGL VCLVTSTLVE 

       130        140        150        160        170        180 
SGAGTGWTVY PPLSSIQAHS GPSVDLAIFA LHLTSISSLL GAINFIVTTL NMRTNGMTMH 

       190        200        210        220        230        240 
KLPLFVWSIF ITAFLLLLSL PVLSAGITML LLDRNFNTSF FEVAGGGDPI LYEHLFYFFG 

       250        260        270        280        290        300 
HPEVYILIIP GFGIISHVVS TYSKKPVFGE ISMVYAMASI GLLGFLVWSH HMYIVGLDAD 

       310        320        330        340        350        360 
TRAYFTSATM IIAIPTGIKI FSWLATIYGG SIRLATPMLY AIAFLFLFTM GGLTGVALAN 

       370        380        390        400        410        420 
ASLDVAFHDT YYVVGHFHYV LSMGAIFSLF AGYYYWSPQI LGLNYNEKLA QIQFWLIFIG 

       430        440        450        460        470        480 
ANVIFFPMHF LGINGMPRRI PDYPDAFAGW NYVASIGSFI ATLSLFLFIY ILYDQLVNGL 

       490        500        510        520        530 
NNKVNNKSVI YTKAPDFVES NTIFNLNTVK SSSIEFLLTS PPAVHSFNTP AVQS 

« Hide

References

[1]"Sequence of the mitochondrial gene encoding subunit I of cytochrome oxidase in Saccharomyces douglasii."
Tian G.L., Michel F., Macadre C., Lazowska J.
Gene 124:153-163(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: SD12.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M97514 Genomic DNA. Translation: AAB58808.1. Sequence problems.

3D structure databases

ProteinModelPortalP98001.
SMRP98001. Positions 2-532.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00705.

Family and domain databases

Gene3D1.20.210.10. 1 hit.
InterProIPR000883. Cyt_c_Oxase_su1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERPTHR10422. PTHR10422. 1 hit.
PfamPF00115. COX1. 1 hit.
[Graphical view]
PRINTSPR01165. CYCOXIDASEI.
SUPFAMSSF81442. SSF81442. 1 hit.
PROSITEPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX1_SACDO
AccessionPrimary (citable) accession number: P98001
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: April 16, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways