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P98000

- COXN_BRADU

UniProt

P98000 - COXN_BRADU

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Protein
Alternative cytochrome c oxidase subunit 1
Gene
coxN, bll3784
Organism
Bradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Co I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and a low-spin heme of subunit 1 to the bimetallic center formed by a high-spin heme and copper B.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi88 – 881Iron (low-spin heme axial ligand) Inferred
Metal bindingi280 – 2801Copper B Inferred
Metal bindingi284 – 2841Copper B Inferred
Metal bindingi329 – 3291Copper B Inferred
Metal bindingi330 – 3301Copper B Inferred
Metal bindingi415 – 4151Iron (high-spin heme axial ligand) Inferred
Metal bindingi417 – 4171Iron (low-spin heme axial ligand) Inferred

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro

GO - Biological processi

  1. aerobic respiration Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciBJAP224911:GJEJ-3808-MONOMER.
RETL1328306-WGS:GSTH-2649-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Alternative cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Alternative cytochrome c oxidase polypeptide I
Cytochrome BB3 subunit 1
Oxidase BB(3) subunit 1
Gene namesi
Name:coxN
Ordered Locus Names:bll3784
OrganismiBradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Taxonomic identifieri224911 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeBradyrhizobium
ProteomesiUP000002526: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei40 – 6021Helical; Reviewed prediction
Add
BLAST
Transmembranei90 – 11021Helical; Reviewed prediction
Add
BLAST
Transmembranei126 – 14621Helical; Reviewed prediction
Add
BLAST
Transmembranei172 – 19221Helical; Reviewed prediction
Add
BLAST
Transmembranei215 – 23521Helical; Reviewed prediction
Add
BLAST
Transmembranei274 – 29421Helical; Reviewed prediction
Add
BLAST
Transmembranei313 – 33321Helical; Reviewed prediction
Add
BLAST
Transmembranei337 – 35721Helical; Reviewed prediction
Add
BLAST
Transmembranei377 – 39721Helical; Reviewed prediction
Add
BLAST
Transmembranei412 – 43221Helical; Reviewed prediction
Add
BLAST
Transmembranei453 – 47321Helical; Reviewed prediction
Add
BLAST
Transmembranei498 – 51821Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 591591Alternative cytochrome c oxidase subunit 1
PRO_0000183454Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki280 ↔ 2841'-histidyl-3'-tyrosine (His-Tyr) By similarity

Expressioni

Developmental stagei

Bacteroid (nitrogen-fixing endosymbiont).

Interactioni

Subunit structurei

This alternate cytochrome c oxidase consists of a subunit I and two cytochromes c. Equivalents to subunit 2 and 3 are not present in this complex.

Protein-protein interaction databases

STRINGi224911.bll3784.

Structurei

3D structure databases

ProteinModelPortaliP98000.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0843.
HOGENOMiHOG000085274.
KOiK02274.
OrthoDBiEOG6B35XR.
PhylomeDBiP98000.

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P98000-1 [UniParc]FASTAAdd to Basket

« Hide

MVDVPYDRIA DIPPAEVPDV ELYHPRSWWT RYVFSQDAKV IAIQYSLTAS    50
AIGLVALVLS WLMRLQLGFP GTFSFIDANQ YLQFITMHGM IMVIYLLTAL 100
FLGGFGNYLI PLMVGARDMV FPYVNMLSYW VYLLAVLVLA SAFFVPGGPT 150
GAGWTLYPPQ AILSGTPGQD WGIVLMLSSL ILFIIGFTMG GLNYVVTVLQ 200
ARTRGMTLMR LPLTVWGIFT ATVMALLAFP ALFVGSVMLL LDRLLGTSFF 250
MPTLVEMGQL SKYGGGSPLL FQHLFWFFGH PEVYIVALPA FGIVSDLIST 300
HARKNIFGYR MMVWAIVAIG ALSFVVWAHH MYVSGMYPYF GFFFATTTLI 350
IAIPTAIKVY NWVLTLWHGD IHLTVPMLFA LGFIITFVNG GLTGLFLGNV 400
VVDVPLSDTM FVVAHFHMVM GVAPIMVVLG AIYHWYPKVT GRMLNDVLGK 450
FHFWVTFLGA YLIFFPMHYL GLLGVPRRYF ELGDAAFIPP SAHSLNAFIT 500
VVALTVGFAQ MVFLFNLVWS LFEGEPSGGN PWRATTLEWQ TPETPPGHGN 550
WGKQLPIVYR WAYDYSVPGA AQDFIPQNQP PPTGAVQGVA P 591
Length:591
Mass (Da):65,654
Last modified:February 1, 1996 - v1
Checksum:iF58B0B43EE21903E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X68547 Genomic DNA. Translation: CAA48548.1.
BA000040 Genomic DNA. Translation: BAC49049.1.
PIRiC48364.
RefSeqiNP_770424.1. NC_004463.1.

Genome annotation databases

EnsemblBacteriaiBAC49049; BAC49049; BAC49049.
GeneIDi1053034.
KEGGibja:bll3784.
PATRICi21191035. VBIBraJap65052_3775.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X68547 Genomic DNA. Translation: CAA48548.1 .
BA000040 Genomic DNA. Translation: BAC49049.1 .
PIRi C48364.
RefSeqi NP_770424.1. NC_004463.1.

3D structure databases

ProteinModelPortali P98000.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224911.bll3784.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAC49049 ; BAC49049 ; BAC49049 .
GeneIDi 1053034.
KEGGi bja:bll3784.
PATRICi 21191035. VBIBraJap65052_3775.

Phylogenomic databases

eggNOGi COG0843.
HOGENOMi HOG000085274.
KOi K02274.
OrthoDBi EOG6B35XR.
PhylomeDBi P98000.

Enzyme and pathway databases

BioCyci BJAP224911:GJEJ-3808-MONOMER.
RETL1328306-WGS:GSTH-2649-MONOMER.

Family and domain databases

Gene3Di 1.20.210.10. 1 hit.
InterProi IPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view ]
PANTHERi PTHR10422. PTHR10422. 1 hit.
Pfami PF00115. COX1. 1 hit.
[Graphical view ]
PRINTSi PR01165. CYCOXIDASEI.
SUPFAMi SSF81442. SSF81442. 1 hit.
PROSITEi PS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genes for a second terminal oxidase in Bradyrhizobium japonicum."
    Bott M., Preisig O., Hennecke H.
    Arch. Microbiol. 158:335-343(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: USDA 110spc4.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110.

Entry informationi

Entry nameiCOXN_BRADU
AccessioniPrimary (citable) accession number: P98000
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: September 3, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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