Skip Header

Contribute Send feedback
Read comments (?) or add your own

P98000 (COXN_BRAJA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Alternative cytochrome c oxidase subunit 1
EC=1.9.3.1
Alternative name(s):
Alternative cytochrome c oxidase polypeptide I
Cytochrome BB3 subunit 1
Oxidase BB(3) subunit 1
Gene names
Name:coxN
Ordered Locus Names:bll3784
OrganismBradyrhizobium japonicum (strain USDA 110) [Reference proteome] [HAMAP]
Taxonomic identifier224911 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bradyrhizobiaceae › Bradyrhizobium ›

Protein attributes

Sequence length591 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Co I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and a low-spin heme of subunit 1 to the bimetallic center formed by a high-spin heme and copper B.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Subunit structure

This alternate cytochrome c oxidase consists of a subunit I and two cytochromes c. Equivalents to subunit 2 and 3 are not present in this complex.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Developmental stage

Bacteroid (nitrogen-fixing endosymbiont).

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 591591Alternative cytochrome c oxidase subunit 1
PRO_0000183454

Regions

Transmembrane40 – 6021Helical; Potential
Transmembrane90 – 11021Helical; Potential
Transmembrane126 – 14621Helical; Potential
Transmembrane172 – 19221Helical; Potential
Transmembrane215 – 23521Helical; Potential
Transmembrane274 – 29421Helical; Potential
Transmembrane313 – 33321Helical; Potential
Transmembrane337 – 35721Helical; Potential
Transmembrane377 – 39721Helical; Potential
Transmembrane412 – 43221Helical; Potential
Transmembrane453 – 47321Helical; Potential
Transmembrane498 – 51821Helical; Potential

Sites

Metal binding881Iron (low-spin heme axial ligand) Probable
Metal binding2801Copper B Probable
Metal binding2841Copper B Probable
Metal binding3291Copper B Probable
Metal binding3301Copper B Probable
Metal binding4151Iron (high-spin heme axial ligand) Probable
Metal binding4171Iron (low-spin heme axial ligand) Probable

Amino acid modifications

Cross-link280 ↔ 2841'-histidyl-3'-tyrosine (His-Tyr) By similarity

Sequences

Sequence LengthMass (Da)Tools
P98000 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: F58B0B43EE21903E

FASTA59165,654
        10         20         30         40         50         60 
MVDVPYDRIA DIPPAEVPDV ELYHPRSWWT RYVFSQDAKV IAIQYSLTAS AIGLVALVLS 

        70         80         90        100        110        120 
WLMRLQLGFP GTFSFIDANQ YLQFITMHGM IMVIYLLTAL FLGGFGNYLI PLMVGARDMV 

       130        140        150        160        170        180 
FPYVNMLSYW VYLLAVLVLA SAFFVPGGPT GAGWTLYPPQ AILSGTPGQD WGIVLMLSSL 

       190        200        210        220        230        240 
ILFIIGFTMG GLNYVVTVLQ ARTRGMTLMR LPLTVWGIFT ATVMALLAFP ALFVGSVMLL 

       250        260        270        280        290        300 
LDRLLGTSFF MPTLVEMGQL SKYGGGSPLL FQHLFWFFGH PEVYIVALPA FGIVSDLIST 

       310        320        330        340        350        360 
HARKNIFGYR MMVWAIVAIG ALSFVVWAHH MYVSGMYPYF GFFFATTTLI IAIPTAIKVY 

       370        380        390        400        410        420 
NWVLTLWHGD IHLTVPMLFA LGFIITFVNG GLTGLFLGNV VVDVPLSDTM FVVAHFHMVM 

       430        440        450        460        470        480 
GVAPIMVVLG AIYHWYPKVT GRMLNDVLGK FHFWVTFLGA YLIFFPMHYL GLLGVPRRYF 

       490        500        510        520        530        540 
ELGDAAFIPP SAHSLNAFIT VVALTVGFAQ MVFLFNLVWS LFEGEPSGGN PWRATTLEWQ 

       550        560        570        580        590 
TPETPPGHGN WGKQLPIVYR WAYDYSVPGA AQDFIPQNQP PPTGAVQGVA P

« Hide

References

« Hide 'large scale' references
[1]"Genes for a second terminal oxidase in Bradyrhizobium japonicum."
Bott M., Preisig O., Hennecke H.
Arch. Microbiol. 158:335-343(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: USDA 110spc4.
[2]"Complete genomic sequence of nitrogen-fixing symbiotic bacterium Bradyrhizobium japonicum USDA110."
Kaneko T., Nakamura Y., Sato S., Minamisawa K., Uchiumi T., Sasamoto S., Watanabe A., Idesawa K., Iriguchi M., Kawashima K., Kohara M., Matsumoto M., Shimpo S., Tsuruoka H., Wada T., Yamada M., Tabata S.
DNA Res. 9:189-197(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: USDA 110.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X68547 Genomic DNA. Translation: CAA48548.1.
BA000040 Genomic DNA. Translation: BAC49049.1.
PIRC48364.
RefSeqNP_770424.1. NC_004463.1.

3D structure databases

ProteinModelPortalP98000.
ModBaseSearch...

Protein-protein interaction databases

STRING224911.bll3784.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAC49049; BAC49049; BAC49049.
GeneID1053034.
KEGGbja:bll3784.
PATRIC21191035. VBIBraJap65052_3775.

Phylogenomic databases

eggNOGCOG0843.
HOGENOMHOG000085274.
KOK02274.
OMARSWWTRY.
ProtClustDBCLSK783127.

Enzyme and pathway databases

BioCycBJAP224911:GJEJ-3808-MONOMER.

Family and domain databases

Gene3D1.20.210.10. 1 hit.
InterProIPR000883. Cyt_c_Oxase_su1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERPTHR10422. PTHR10422. 1 hit.
PfamPF00115. COX1. 1 hit.
[Graphical view]
PRINTSPR01165. CYCOXIDASEI.
SUPFAMSSF81442. COX1. 1 hit.
PROSITEPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOXN_BRAJA
AccessionPrimary (citable) accession number: P98000
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: May 1, 2013
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents