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Protein

Alternative cytochrome c oxidase subunit 1

Gene

coxN

Organism
Bradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Co I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and a low-spin heme of subunit 1 to the bimetallic center formed by a high-spin heme and copper B.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi88Iron (low-spin heme axial ligand)Curated1
Metal bindingi280Copper BCurated1
Metal bindingi284Copper BCurated1
Metal bindingi329Copper BCurated1
Metal bindingi330Copper BCurated1
Metal bindingi415Iron (high-spin heme axial ligand)Curated1
Metal bindingi417Iron (low-spin heme axial ligand)Curated1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Alternative cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Alternative cytochrome c oxidase polypeptide I
Cytochrome BB3 subunit 1
Oxidase BB(3) subunit 1
Gene namesi
Name:coxN
Ordered Locus Names:bll3784
OrganismiBradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Taxonomic identifieri224911 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeBradyrhizobium
Proteomesi
  • UP000002526 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei40 – 60HelicalSequence analysisAdd BLAST21
Transmembranei90 – 110HelicalSequence analysisAdd BLAST21
Transmembranei126 – 146HelicalSequence analysisAdd BLAST21
Transmembranei172 – 192HelicalSequence analysisAdd BLAST21
Transmembranei215 – 235HelicalSequence analysisAdd BLAST21
Transmembranei274 – 294HelicalSequence analysisAdd BLAST21
Transmembranei313 – 333HelicalSequence analysisAdd BLAST21
Transmembranei337 – 357HelicalSequence analysisAdd BLAST21
Transmembranei377 – 397HelicalSequence analysisAdd BLAST21
Transmembranei412 – 432HelicalSequence analysisAdd BLAST21
Transmembranei453 – 473HelicalSequence analysisAdd BLAST21
Transmembranei498 – 518HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001834541 – 591Alternative cytochrome c oxidase subunit 1Add BLAST591

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki280 ↔ 2841'-histidyl-3'-tyrosine (His-Tyr)By similarity

Expressioni

Developmental stagei

Bacteroid (nitrogen-fixing endosymbiont).

Interactioni

Subunit structurei

This alternate cytochrome c oxidase consists of a subunit I and two cytochromes c. Equivalents to subunit 2 and 3 are not present in this complex.

Protein-protein interaction databases

STRINGi224911.bll3784.

Structurei

3D structure databases

ProteinModelPortaliP98000.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105BZ9. Bacteria.
COG0843. LUCA.
HOGENOMiHOG000085274.
InParanoidiP98000.
KOiK02274.
OMAiIAILPGM.
OrthoDBiPOG091H042R.
PhylomeDBiP98000.

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023616. Cyt_c_oxase-like_su1_dom.
IPR023615. Cyt_c_Oxase_su1_BS.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P98000-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVDVPYDRIA DIPPAEVPDV ELYHPRSWWT RYVFSQDAKV IAIQYSLTAS
60 70 80 90 100
AIGLVALVLS WLMRLQLGFP GTFSFIDANQ YLQFITMHGM IMVIYLLTAL
110 120 130 140 150
FLGGFGNYLI PLMVGARDMV FPYVNMLSYW VYLLAVLVLA SAFFVPGGPT
160 170 180 190 200
GAGWTLYPPQ AILSGTPGQD WGIVLMLSSL ILFIIGFTMG GLNYVVTVLQ
210 220 230 240 250
ARTRGMTLMR LPLTVWGIFT ATVMALLAFP ALFVGSVMLL LDRLLGTSFF
260 270 280 290 300
MPTLVEMGQL SKYGGGSPLL FQHLFWFFGH PEVYIVALPA FGIVSDLIST
310 320 330 340 350
HARKNIFGYR MMVWAIVAIG ALSFVVWAHH MYVSGMYPYF GFFFATTTLI
360 370 380 390 400
IAIPTAIKVY NWVLTLWHGD IHLTVPMLFA LGFIITFVNG GLTGLFLGNV
410 420 430 440 450
VVDVPLSDTM FVVAHFHMVM GVAPIMVVLG AIYHWYPKVT GRMLNDVLGK
460 470 480 490 500
FHFWVTFLGA YLIFFPMHYL GLLGVPRRYF ELGDAAFIPP SAHSLNAFIT
510 520 530 540 550
VVALTVGFAQ MVFLFNLVWS LFEGEPSGGN PWRATTLEWQ TPETPPGHGN
560 570 580 590
WGKQLPIVYR WAYDYSVPGA AQDFIPQNQP PPTGAVQGVA P
Length:591
Mass (Da):65,654
Last modified:February 1, 1996 - v1
Checksum:iF58B0B43EE21903E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X68547 Genomic DNA. Translation: CAA48548.1.
BA000040 Genomic DNA. Translation: BAC49049.1.
PIRiC48364.
RefSeqiNP_770424.1. NC_004463.1.
WP_011086565.1. NZ_CP011360.1.

Genome annotation databases

EnsemblBacteriaiBAC49049; BAC49049; BAC49049.
GeneIDi1053034.
KEGGibja:bll3784.
PATRICi21191035. VBIBraJap65052_3775.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X68547 Genomic DNA. Translation: CAA48548.1.
BA000040 Genomic DNA. Translation: BAC49049.1.
PIRiC48364.
RefSeqiNP_770424.1. NC_004463.1.
WP_011086565.1. NZ_CP011360.1.

3D structure databases

ProteinModelPortaliP98000.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224911.bll3784.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAC49049; BAC49049; BAC49049.
GeneIDi1053034.
KEGGibja:bll3784.
PATRICi21191035. VBIBraJap65052_3775.

Phylogenomic databases

eggNOGiENOG4105BZ9. Bacteria.
COG0843. LUCA.
HOGENOMiHOG000085274.
InParanoidiP98000.
KOiK02274.
OMAiIAILPGM.
OrthoDBiPOG091H042R.
PhylomeDBiP98000.

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023616. Cyt_c_oxase-like_su1_dom.
IPR023615. Cyt_c_Oxase_su1_BS.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCOXN_BRADU
AccessioniPrimary (citable) accession number: P98000
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 30, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.