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Protein

Alternative cytochrome c oxidase subunit 1

Gene

coxN

Organism
Bradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Co I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and a low-spin heme of subunit 1 to the bimetallic center formed by a high-spin heme and copper B.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi88Iron (low-spin heme axial ligand)Curated1
Metal bindingi280Copper BCurated1
Metal bindingi284Copper BCurated1
Metal bindingi329Copper BCurated1
Metal bindingi330Copper BCurated1
Metal bindingi415Iron (high-spin heme axial ligand)Curated1
Metal bindingi417Iron (low-spin heme axial ligand)Curated1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Respiratory chain, Transport
LigandCopper, Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciBDIA224911:G1G3J-3808-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Alternative cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Alternative cytochrome c oxidase polypeptide I
Cytochrome BB3 subunit 1
Oxidase BB(3) subunit 1
Gene namesi
Name:coxN
Ordered Locus Names:bll3784
OrganismiBradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Taxonomic identifieri224911 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeBradyrhizobium
Proteomesi
  • UP000002526 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei40 – 60HelicalSequence analysisAdd BLAST21
Transmembranei90 – 110HelicalSequence analysisAdd BLAST21
Transmembranei126 – 146HelicalSequence analysisAdd BLAST21
Transmembranei172 – 192HelicalSequence analysisAdd BLAST21
Transmembranei215 – 235HelicalSequence analysisAdd BLAST21
Transmembranei274 – 294HelicalSequence analysisAdd BLAST21
Transmembranei313 – 333HelicalSequence analysisAdd BLAST21
Transmembranei337 – 357HelicalSequence analysisAdd BLAST21
Transmembranei377 – 397HelicalSequence analysisAdd BLAST21
Transmembranei412 – 432HelicalSequence analysisAdd BLAST21
Transmembranei453 – 473HelicalSequence analysisAdd BLAST21
Transmembranei498 – 518HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001834541 – 591Alternative cytochrome c oxidase subunit 1Add BLAST591

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki280 ↔ 2841'-histidyl-3'-tyrosine (His-Tyr)By similarity

Proteomic databases

PRIDEiP98000

Expressioni

Developmental stagei

Bacteroid (nitrogen-fixing endosymbiont).

Interactioni

Subunit structurei

This alternate cytochrome c oxidase consists of a subunit I and two cytochromes c. Equivalents to subunit 2 and 3 are not present in this complex.

Protein-protein interaction databases

STRINGi224911.bll3784

Structurei

3D structure databases

ProteinModelPortaliP98000
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105BZ9 Bacteria
COG0843 LUCA
HOGENOMiHOG000085274
InParanoidiP98000
KOiK02274
OMAiPPAHGNW
OrthoDBiPOG091H042R
PhylomeDBiP98000

Family and domain databases

Gene3Di1.20.210.10, 1 hit
InterProiView protein in InterPro
IPR023616 Cyt_c_oxase-like_su1_dom
IPR036927 Cyt_c_oxase-like_su1_sf
IPR000883 Cyt_C_Oxase_1
IPR023615 Cyt_c_Oxase_su1_BS
PANTHERiPTHR10422 PTHR10422, 1 hit
PfamiView protein in Pfam
PF00115 COX1, 1 hit
PRINTSiPR01165 CYCOXIDASEI
SUPFAMiSSF81442 SSF81442, 1 hit
PROSITEiView protein in PROSITE
PS50855 COX1, 1 hit
PS00077 COX1_CUB, 1 hit

Sequencei

Sequence statusi: Complete.

P98000-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVDVPYDRIA DIPPAEVPDV ELYHPRSWWT RYVFSQDAKV IAIQYSLTAS
60 70 80 90 100
AIGLVALVLS WLMRLQLGFP GTFSFIDANQ YLQFITMHGM IMVIYLLTAL
110 120 130 140 150
FLGGFGNYLI PLMVGARDMV FPYVNMLSYW VYLLAVLVLA SAFFVPGGPT
160 170 180 190 200
GAGWTLYPPQ AILSGTPGQD WGIVLMLSSL ILFIIGFTMG GLNYVVTVLQ
210 220 230 240 250
ARTRGMTLMR LPLTVWGIFT ATVMALLAFP ALFVGSVMLL LDRLLGTSFF
260 270 280 290 300
MPTLVEMGQL SKYGGGSPLL FQHLFWFFGH PEVYIVALPA FGIVSDLIST
310 320 330 340 350
HARKNIFGYR MMVWAIVAIG ALSFVVWAHH MYVSGMYPYF GFFFATTTLI
360 370 380 390 400
IAIPTAIKVY NWVLTLWHGD IHLTVPMLFA LGFIITFVNG GLTGLFLGNV
410 420 430 440 450
VVDVPLSDTM FVVAHFHMVM GVAPIMVVLG AIYHWYPKVT GRMLNDVLGK
460 470 480 490 500
FHFWVTFLGA YLIFFPMHYL GLLGVPRRYF ELGDAAFIPP SAHSLNAFIT
510 520 530 540 550
VVALTVGFAQ MVFLFNLVWS LFEGEPSGGN PWRATTLEWQ TPETPPGHGN
560 570 580 590
WGKQLPIVYR WAYDYSVPGA AQDFIPQNQP PPTGAVQGVA P
Length:591
Mass (Da):65,654
Last modified:February 1, 1996 - v1
Checksum:iF58B0B43EE21903E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X68547 Genomic DNA Translation: CAA48548.1
BA000040 Genomic DNA Translation: BAC49049.1
PIRiC48364
RefSeqiNP_770424.1, NC_004463.1
WP_011086565.1, NZ_CP011360.1

Genome annotation databases

EnsemblBacteriaiBAC49049; BAC49049; BAC49049
GeneIDi1053034
KEGGibja:bll3784
PATRICifig|224911.44.peg.3452

Similar proteinsi

Entry informationi

Entry nameiCOXN_BRADU
AccessioniPrimary (citable) accession number: P98000
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: May 23, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health