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P98000

- COXN_BRADU

UniProt

P98000 - COXN_BRADU

Protein

Alternative cytochrome c oxidase subunit 1

Gene

coxN

Organism
Bradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Co I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and a low-spin heme of subunit 1 to the bimetallic center formed by a high-spin heme and copper B.

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi88 – 881Iron (low-spin heme axial ligand)Curated
    Metal bindingi280 – 2801Copper BCurated
    Metal bindingi284 – 2841Copper BCurated
    Metal bindingi329 – 3291Copper BCurated
    Metal bindingi330 – 3301Copper BCurated
    Metal bindingi415 – 4151Iron (high-spin heme axial ligand)Curated
    Metal bindingi417 – 4171Iron (low-spin heme axial ligand)Curated

    GO - Molecular functioni

    1. cytochrome-c oxidase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    GO - Biological processi

    1. aerobic respiration Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    Copper, Heme, Iron, Metal-binding

    Enzyme and pathway databases

    BioCyciBJAP224911:GJEJ-3808-MONOMER.
    RETL1328306-WGS:GSTH-2649-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alternative cytochrome c oxidase subunit 1 (EC:1.9.3.1)
    Alternative name(s):
    Alternative cytochrome c oxidase polypeptide I
    Cytochrome BB3 subunit 1
    Oxidase BB(3) subunit 1
    Gene namesi
    Name:coxN
    Ordered Locus Names:bll3784
    OrganismiBradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
    Taxonomic identifieri224911 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeBradyrhizobium
    ProteomesiUP000002526: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell
    3. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 591591Alternative cytochrome c oxidase subunit 1PRO_0000183454Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Cross-linki280 ↔ 2841'-histidyl-3'-tyrosine (His-Tyr)By similarity

    Expressioni

    Developmental stagei

    Bacteroid (nitrogen-fixing endosymbiont).

    Interactioni

    Subunit structurei

    This alternate cytochrome c oxidase consists of a subunit I and two cytochromes c. Equivalents to subunit 2 and 3 are not present in this complex.

    Protein-protein interaction databases

    STRINGi224911.bll3784.

    Structurei

    3D structure databases

    ProteinModelPortaliP98000.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei40 – 6021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei90 – 11021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei126 – 14621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei172 – 19221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei215 – 23521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei274 – 29421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei313 – 33321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei337 – 35721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei377 – 39721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei412 – 43221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei453 – 47321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei498 – 51821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0843.
    HOGENOMiHOG000085274.
    KOiK02274.
    OrthoDBiEOG6B35XR.
    PhylomeDBiP98000.

    Family and domain databases

    Gene3Di1.20.210.10. 1 hit.
    InterProiIPR000883. COX1.
    IPR023615. Cyt_c_Oxase_su1_BS.
    IPR023616. Cyt_c_Oxase_su1_dom.
    [Graphical view]
    PANTHERiPTHR10422. PTHR10422. 1 hit.
    PfamiPF00115. COX1. 1 hit.
    [Graphical view]
    PRINTSiPR01165. CYCOXIDASEI.
    SUPFAMiSSF81442. SSF81442. 1 hit.
    PROSITEiPS50855. COX1. 1 hit.
    PS00077. COX1_CUB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P98000-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVDVPYDRIA DIPPAEVPDV ELYHPRSWWT RYVFSQDAKV IAIQYSLTAS    50
    AIGLVALVLS WLMRLQLGFP GTFSFIDANQ YLQFITMHGM IMVIYLLTAL 100
    FLGGFGNYLI PLMVGARDMV FPYVNMLSYW VYLLAVLVLA SAFFVPGGPT 150
    GAGWTLYPPQ AILSGTPGQD WGIVLMLSSL ILFIIGFTMG GLNYVVTVLQ 200
    ARTRGMTLMR LPLTVWGIFT ATVMALLAFP ALFVGSVMLL LDRLLGTSFF 250
    MPTLVEMGQL SKYGGGSPLL FQHLFWFFGH PEVYIVALPA FGIVSDLIST 300
    HARKNIFGYR MMVWAIVAIG ALSFVVWAHH MYVSGMYPYF GFFFATTTLI 350
    IAIPTAIKVY NWVLTLWHGD IHLTVPMLFA LGFIITFVNG GLTGLFLGNV 400
    VVDVPLSDTM FVVAHFHMVM GVAPIMVVLG AIYHWYPKVT GRMLNDVLGK 450
    FHFWVTFLGA YLIFFPMHYL GLLGVPRRYF ELGDAAFIPP SAHSLNAFIT 500
    VVALTVGFAQ MVFLFNLVWS LFEGEPSGGN PWRATTLEWQ TPETPPGHGN 550
    WGKQLPIVYR WAYDYSVPGA AQDFIPQNQP PPTGAVQGVA P 591
    Length:591
    Mass (Da):65,654
    Last modified:February 1, 1996 - v1
    Checksum:iF58B0B43EE21903E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X68547 Genomic DNA. Translation: CAA48548.1.
    BA000040 Genomic DNA. Translation: BAC49049.1.
    PIRiC48364.
    RefSeqiNP_770424.1. NC_004463.1.

    Genome annotation databases

    EnsemblBacteriaiBAC49049; BAC49049; BAC49049.
    GeneIDi1053034.
    KEGGibja:bll3784.
    PATRICi21191035. VBIBraJap65052_3775.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X68547 Genomic DNA. Translation: CAA48548.1 .
    BA000040 Genomic DNA. Translation: BAC49049.1 .
    PIRi C48364.
    RefSeqi NP_770424.1. NC_004463.1.

    3D structure databases

    ProteinModelPortali P98000.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 224911.bll3784.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAC49049 ; BAC49049 ; BAC49049 .
    GeneIDi 1053034.
    KEGGi bja:bll3784.
    PATRICi 21191035. VBIBraJap65052_3775.

    Phylogenomic databases

    eggNOGi COG0843.
    HOGENOMi HOG000085274.
    KOi K02274.
    OrthoDBi EOG6B35XR.
    PhylomeDBi P98000.

    Enzyme and pathway databases

    BioCyci BJAP224911:GJEJ-3808-MONOMER.
    RETL1328306-WGS:GSTH-2649-MONOMER.

    Family and domain databases

    Gene3Di 1.20.210.10. 1 hit.
    InterProi IPR000883. COX1.
    IPR023615. Cyt_c_Oxase_su1_BS.
    IPR023616. Cyt_c_Oxase_su1_dom.
    [Graphical view ]
    PANTHERi PTHR10422. PTHR10422. 1 hit.
    Pfami PF00115. COX1. 1 hit.
    [Graphical view ]
    PRINTSi PR01165. CYCOXIDASEI.
    SUPFAMi SSF81442. SSF81442. 1 hit.
    PROSITEi PS50855. COX1. 1 hit.
    PS00077. COX1_CUB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genes for a second terminal oxidase in Bradyrhizobium japonicum."
      Bott M., Preisig O., Hennecke H.
      Arch. Microbiol. 158:335-343(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: USDA 110spc4.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110.

    Entry informationi

    Entry nameiCOXN_BRADU
    AccessioniPrimary (citable) accession number: P98000
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 109 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3