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P97953

- VEGFC_MOUSE

UniProt

P97953 - VEGFC_MOUSE

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Protein
Vascular endothelial growth factor C
Gene
Vegfc
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Growth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors.2 Publications

GO - Molecular functioni

  1. chemoattractant activity Source: Ensembl
  2. protein binding Source: MGI
  3. vascular endothelial growth factor receptor 3 binding Source: MGI

GO - Biological processi

  1. angiogenesis Source: UniProtKB-KW
  2. induction of positive chemotaxis Source: Ensembl
  3. morphogenesis of embryonic epithelium Source: MGI
  4. negative regulation of blood pressure Source: Ensembl
  5. negative regulation of cell proliferation Source: MGI
  6. organ morphogenesis Source: MGI
  7. positive regulation of angiogenesis Source: BHF-UCL
  8. positive regulation of blood vessel endothelial cell migration Source: Ensembl
  9. positive regulation of cell division Source: UniProtKB-KW
  10. positive regulation of cell proliferation Source: MGI
  11. positive regulation of cell-matrix adhesion Source: MGI
  12. positive regulation of epithelial cell proliferation Source: Ensembl
  13. positive regulation of lymphangiogenesis Source: BHF-UCL
  14. positive regulation of mast cell chemotaxis Source: Ensembl
  15. positive regulation of neuroblast proliferation Source: Ensembl
  16. positive regulation of peptidyl-tyrosine phosphorylation Source: MGI
  17. positive regulation of protein autophosphorylation Source: Ensembl
  18. positive regulation of protein secretion Source: Ensembl
  19. regulation of vascular endothelial growth factor receptor signaling pathway Source: Ensembl
  20. response to drug Source: Ensembl
  21. vascular endothelial growth factor receptor signaling pathway Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Growth factor, Mitogen

Keywords - Biological processi

Angiogenesis, Differentiation

Enzyme and pathway databases

ReactomeiREACT_205099. VEGF binds to VEGFR leading to receptor dimerization.
REACT_224551. VEGF ligand-receptor interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Vascular endothelial growth factor C
Short name:
VEGF-C
Alternative name(s):
Flt4 ligand
Short name:
Flt4-L
Vascular endothelial growth factor-related protein
Short name:
VRP
Gene namesi
Name:Vegfc
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 8

Organism-specific databases

MGIiMGI:109124. Vegfc.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: BHF-UCL
  2. membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3131 By similarity
Add
BLAST
Propeptidei32 – 10776 Reviewed prediction
PRO_0000023403Add
BLAST
Chaini108 – 223116Vascular endothelial growth factor C
PRO_0000023404Add
BLAST
Propeptidei224 – 415192 Reviewed prediction
PRO_0000023405Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi127 ↔ 169 By similarity
Disulfide bondi152 – 152Interchain By similarity
Disulfide bondi158 ↔ 205 By similarity
Disulfide bondi161 – 161Interchain By similarity
Disulfide bondi162 ↔ 207 By similarity
Glycosylationi171 – 1711N-linked (GlcNAc...) Reviewed prediction
Glycosylationi201 – 2011N-linked (GlcNAc...) Reviewed prediction
Glycosylationi236 – 2361N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

Undergoes a complex proteolytic maturation which generates a variety of processed secreted forms with increased activity toward VEGFR-3, but only the fully processed form could activate VEGFR-2. VEGF-C first form an antiparallel homodimer linked by disulfide bonds. Before secretion, a cleavage occurs between Arg-223 and Ser-224 producing a heterotetramer. The next extracellular step of the processing removes the N-terminal propeptide. Finally the mature VEGF-C is composed mostly of two VEGF homology domains (VHDs) bound by non-covalent interactions By similarity.

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP97953.

PTM databases

PhosphoSiteiP97953.

Expressioni

Tissue specificityi

Expressed in adult heart, brain, spleen, lung, liver, skeletal muscle, kidney, testis and intestine with higher levels in heart, brain and kidney. Isoform 4 levels are very low. Isoform 3 is mostly expressed in liver and has reduced expression level in other tissues. Isoform 2 is mostly expressed in brain and kidney, although a lower level expression in other tissues is also detectable.3 Publications

Developmental stagei

Expression detected in mesenchymal cells of postimplantation embryos, particularly in the regions where the lymphatic vessels undergo sprouting from embryonic veins, such as the perimetanephric, axillary and jugular regions, and in the developing mesenterium. Also detected between vertebral corpuscles, in lung mesenchyme, in neck region and in developing forehead. Not detected in the blood islands of the yolk sac.1 Publication

Gene expression databases

BgeeiP97953.
CleanExiMM_VEGFC.
GenevestigatoriP97953.

Interactioni

Subunit structurei

Homodimer; non-covalent and antiparallel.1 Publication

Protein-protein interaction databases

BioGridi204514. 1 interaction.
STRINGi10090.ENSMUSP00000033919.

Structurei

3D structure databases

ProteinModelPortaliP97953.
SMRiP97953. Positions 113-211.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati276 – 291161
Add
BLAST
Repeati300 – 315162
Add
BLAST
Repeati324 – 339163
Add
BLAST
Repeati343 – 358164
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni276 – 358834 X 16 AA repeats of C-X(10)-C-X-C-X(1,3)-C
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG79308.
GeneTreeiENSGT00730000110889.
HOGENOMiHOG000231512.
HOVERGENiHBG073119.
InParanoidiP97953.
KOiK05449.
OMAiTCPRNQP.
OrthoDBiEOG7J17ZS.
PhylomeDBiP97953.
TreeFamiTF319554.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR004153. CXCXC_repeat.
IPR029034. Cystine-knot_cytokine.
IPR023581. PD_growth_factor_CS.
IPR000072. PDGF/VEGF_dom.
[Graphical view]
PfamiPF03128. CXCXC. 3 hits.
PF00341. PDGF. 1 hit.
[Graphical view]
SMARTiSM00141. PDGF. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00249. PDGF_1. 1 hit.
PS50278. PDGF_2. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P97953-1) [UniParc]FASTAAdd to Basket

Also known as: Vegf-C

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MHLLCFLSLA CSLLAAALIP SPREAPATVA AFESGLGFSE AEPDGGEVKA    50
FEGKDLEEQL RSVSSVDELM SVLYPDYWKM YKCQLRKGGW QQPTLNTRTG 100
DSVKFAAAHY NTEILKSIDN EWRKTQCMPR EVCIDVGKEF GAATNTFFKP 150
PCVSVYRCGG CCNSEGLQCM NTSTGYLSKT LFEITVPLSQ GPKPVTISFA 200
NHTSCRCMSK LDVYRQVHSI IRRSLPATLP QCQAANKTCP TNYVWNNYMC 250
RCLAQQDFIF YSNVEDDSTN GFHDVCGPNK ELDEDTCQCV CKGGLRPSSC 300
GPHKELDRDS CQCVCKNKLF PNSCGANREF DENTCQCVCK RTCPRNQPLN 350
PGKCACECTE NTQKCFLKGK KFHHQTCSCY RRPCANRLKH CDPGLSFSEE 400
VCRCVPSYWK RPHLN 415
Length:415
Mass (Da):46,471
Last modified:May 1, 1997 - v1
Checksum:iD9D3DD3CECC659D6
GO
Isoform 2 (identifier: P97953-2) [UniParc]FASTAAdd to Basket

Also known as: Vegf-C184

The sequence of this isoform differs from the canonical sequence as follows:
     181-184: LFEI → VSGS
     185-415: Missing.

Show »
Length:184
Mass (Da):20,120
Checksum:i244E323EA999A516
GO
Isoform 3 (identifier: P97953-3) [UniParc]FASTAAdd to Basket

Also known as: Vegf-C129

The sequence of this isoform differs from the canonical sequence as follows:
     117-129: SIDNEWRKTQCMP → NVGVAATARGCSA
     130-184: Missing.
     185-415: Missing.

Show »
Length:129
Mass (Da):13,902
Checksum:i83AA659AA707FD1F
GO
Isoform 4 (identifier: P97953-4) [UniParc]FASTAAdd to Basket

Also known as: Vegf-C62

The sequence of this isoform differs from the canonical sequence as follows:
     50-62: AFEGKDLEEQLRS → LLQKTVCESTEAL
     63-129: Missing.
     130-184: Missing.
     185-415: Missing.

Show »
Length:62
Mass (Da):6,405
Checksum:i08538283DAC3AEB2
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei50 – 6213AFEGK…EQLRS → LLQKTVCESTEAL in isoform 4.
VSP_053477Add
BLAST
Alternative sequencei63 – 12967Missing in isoform 4.
VSP_053478Add
BLAST
Alternative sequencei117 – 12913SIDNE…TQCMP → NVGVAATARGCSA in isoform 3.
VSP_053479Add
BLAST
Alternative sequencei130 – 18455Missing in isoform 3 and isoform 4.
VSP_053480Add
BLAST
Alternative sequencei181 – 1844LFEI → VSGS in isoform 2.
VSP_053481
Alternative sequencei185 – 415231Missing in isoform 2, isoform 3 and isoform 4.
VSP_053482Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U73620 mRNA. Translation: AAC52984.1.
U58112 mRNA. Translation: AAB46707.1.
EU862553 mRNA. Translation: ACJ54375.1.
EU862554 mRNA. Translation: ACJ54376.1.
EU862555 mRNA. Translation: ACJ54377.1.
AK047844 mRNA. Translation: BAC33172.1.
CH466554 Genomic DNA. Translation: EDL35638.1.
BC096377 mRNA. Translation: AAH96377.1.
CCDSiCCDS22306.1. [P97953-1]
RefSeqiNP_033532.1. NM_009506.2. [P97953-1]
UniGeneiMm.1402.

Genome annotation databases

EnsembliENSMUST00000033919; ENSMUSP00000033919; ENSMUSG00000031520. [P97953-1]
GeneIDi22341.
KEGGimmu:22341.
UCSCiuc009lsc.1. mouse. [P97953-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U73620 mRNA. Translation: AAC52984.1 .
U58112 mRNA. Translation: AAB46707.1 .
EU862553 mRNA. Translation: ACJ54375.1 .
EU862554 mRNA. Translation: ACJ54376.1 .
EU862555 mRNA. Translation: ACJ54377.1 .
AK047844 mRNA. Translation: BAC33172.1 .
CH466554 Genomic DNA. Translation: EDL35638.1 .
BC096377 mRNA. Translation: AAH96377.1 .
CCDSi CCDS22306.1. [P97953-1 ]
RefSeqi NP_033532.1. NM_009506.2. [P97953-1 ]
UniGenei Mm.1402.

3D structure databases

ProteinModelPortali P97953.
SMRi P97953. Positions 113-211.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 204514. 1 interaction.
STRINGi 10090.ENSMUSP00000033919.

PTM databases

PhosphoSitei P97953.

Proteomic databases

PRIDEi P97953.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000033919 ; ENSMUSP00000033919 ; ENSMUSG00000031520 . [P97953-1 ]
GeneIDi 22341.
KEGGi mmu:22341.
UCSCi uc009lsc.1. mouse. [P97953-1 ]

Organism-specific databases

CTDi 7424.
MGIi MGI:109124. Vegfc.

Phylogenomic databases

eggNOGi NOG79308.
GeneTreei ENSGT00730000110889.
HOGENOMi HOG000231512.
HOVERGENi HBG073119.
InParanoidi P97953.
KOi K05449.
OMAi TCPRNQP.
OrthoDBi EOG7J17ZS.
PhylomeDBi P97953.
TreeFami TF319554.

Enzyme and pathway databases

Reactomei REACT_205099. VEGF binds to VEGFR leading to receptor dimerization.
REACT_224551. VEGF ligand-receptor interactions.

Miscellaneous databases

NextBioi 302605.
PROi P97953.
SOURCEi Search...

Gene expression databases

Bgeei P97953.
CleanExi MM_VEGFC.
Genevestigatori P97953.

Family and domain databases

Gene3Di 2.10.90.10. 1 hit.
InterProi IPR004153. CXCXC_repeat.
IPR029034. Cystine-knot_cytokine.
IPR023581. PD_growth_factor_CS.
IPR000072. PDGF/VEGF_dom.
[Graphical view ]
Pfami PF03128. CXCXC. 3 hits.
PF00341. PDGF. 1 hit.
[Graphical view ]
SMARTi SM00141. PDGF. 1 hit.
[Graphical view ]
SUPFAMi SSF57501. SSF57501. 1 hit.
PROSITEi PS00249. PDGF_1. 1 hit.
PS50278. PDGF_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "VEGF-C receptor binding and pattern of expression with VEGFR-3 suggests a role in lymphatic vascular development."
    Kukk E., Lymboussaki A., Taira S., Kaipainen A., Jeltsch M., Joukov V., Alitalo K.
    Development 122:3829-3837(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Strain: BALB/c.
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PROTEIN SEQUENCE OF 108-126, FUNCTION, SUBUNIT, TISSUE SPECIFICITY.
    Strain: BALB/c.
  3. "Characterization of novel VEGF (vascular endothelial growth factor)-C splicing isoforms from mouse."
    Wang Z.G., Puri T.S., Quigg R.J.
    Biochem. J. 428:347-354(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 3 AND 4), TISSUE SPECIFICITY.
    Tissue: Kidney proximal tubule.
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Head.
  5. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: FVB/N-3.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiVEGFC_MOUSE
AccessioniPrimary (citable) accession number: P97953
Secondary accession number(s): C6F5S8
, C6F5S9, C6F5T0, Q543R6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 1, 1997
Last modified: September 3, 2014
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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