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Protein

Ras-related protein Rab-33A

Gene

Rab33a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi43 – 50GTPBy similarity8
Nucleotide bindingi91 – 95GTPBy similarity5
Nucleotide bindingi151 – 154GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-8854214. TBC/RABGAPs.

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-33A
Alternative name(s):
Small GTP-binding protein S10
Gene namesi
Name:Rab33a
Synonyms:Rabs10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:109493. Rab33a.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001212381 – 237Ras-related protein Rab-33AAdd BLAST237

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi235S-geranylgeranyl cysteineBy similarity1
Modified residuei237Cysteine methyl esterBy similarity1
Lipidationi237S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

PaxDbiP97950.
PeptideAtlasiP97950.
PRIDEiP97950.

PTM databases

iPTMnetiP97950.
PhosphoSitePlusiP97950.

Expressioni

Tissue specificityi

Expressed predominantly in brain. Weak expression in ovary.

Gene expression databases

BgeeiENSMUSG00000031104.
CleanExiMM_RAB33A.
ExpressionAtlasiP97950. baseline and differential.
GenevisibleiP97950. MM.

Interactioni

Protein-protein interaction databases

IntActiP97950. 9 interactors.
STRINGi10090.ENSMUSP00000033430.

Structurei

3D structure databases

ProteinModelPortaliP97950.
SMRiP97950.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0084. Eukaryota.
ENOG410XQN5. LUCA.
GeneTreeiENSGT00890000139338.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiP97950.
KOiK07919.
OMAiWIEECNG.
OrthoDBiEOG091G0FVM.
PhylomeDBiP97950.
TreeFamiTF300097.

Family and domain databases

InterProiView protein in InterPro
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
PfamiView protein in Pfam
PF00071. Ras. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiView protein in PROSITE
PS51419. RAB. 1 hit.

Sequencei

Sequence statusi: Complete.

P97950-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQPILGHGS LQPASAAGLA SLELDSSMDQ YVQIRIFKII VIGDSNVGKT
60 70 80 90 100
CLTFRFCGGT FPDKTEATIG VDFREKTVEI EGEKIKVQVW DTAGQERFRK
110 120 130 140 150
SMVEHYYRNV HAVVFVYDVT KMTSFTNLKM WIQECNGHAV PPLVPKVLVG
160 170 180 190 200
NKCDLREQIQ VPSNLALKFA DAHNMLLFET SAKDPKESQN VESIFMCLAC
210 220 230
RLKAQKSLLY RDAERQQGKV QKLEFSQEAN GKASCPC
Length:237
Mass (Da):26,541
Last modified:May 1, 1997 - v1
Checksum:i6EF2E03B5E239930
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D83279 mRNA. Translation: BAA11883.1.
D83277 Genomic DNA. Translation: BAA11882.1.
CCDSiCCDS30110.1.
RefSeqiNP_035358.1. NM_011228.2.
UniGeneiMm.2015.

Genome annotation databases

EnsembliENSMUST00000033430; ENSMUSP00000033430; ENSMUSG00000031104.
GeneIDi19337.
KEGGimmu:19337.
UCSCiuc009tci.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiRB33A_MOUSE
AccessioniPrimary (citable) accession number: P97950
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: August 30, 2017
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families