Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ras-related protein Rab-33A

Gene

Rab33a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi43 – 508GTPBy similarity
Nucleotide bindingi91 – 955GTPBy similarity
Nucleotide bindingi151 – 1544GTPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-33A
Alternative name(s):
Small GTP-binding protein S10
Gene namesi
Name:Rab33a
Synonyms:Rabs10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:109493. Rab33a.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 237237Ras-related protein Rab-33APRO_0000121238Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi235 – 2351S-geranylgeranyl cysteineBy similarity
Modified residuei237 – 2371Cysteine methyl esterBy similarity
Lipidationi237 – 2371S-geranylgeranyl cysteineBy similarity

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

PaxDbiP97950.
PeptideAtlasiP97950.
PRIDEiP97950.

PTM databases

iPTMnetiP97950.
PhosphoSiteiP97950.

Expressioni

Tissue specificityi

Expressed predominantly in brain. Weak expression in ovary.

Gene expression databases

BgeeiP97950.
CleanExiMM_RAB33A.
ExpressionAtlasiP97950. baseline and differential.
GenevisibleiP97950. MM.

Interactioni

Protein-protein interaction databases

IntActiP97950. 9 interactions.
STRINGi10090.ENSMUSP00000033430.

Structurei

3D structure databases

ProteinModelPortaliP97950.
SMRiP97950. Positions 35-199.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0084. Eukaryota.
ENOG410XQN5. LUCA.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiP97950.
KOiK07919.
OMAiTWIEECN.
OrthoDBiEOG78PVB5.
PhylomeDBiP97950.
TreeFamiTF300097.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P97950-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQPILGHGS LQPASAAGLA SLELDSSMDQ YVQIRIFKII VIGDSNVGKT
60 70 80 90 100
CLTFRFCGGT FPDKTEATIG VDFREKTVEI EGEKIKVQVW DTAGQERFRK
110 120 130 140 150
SMVEHYYRNV HAVVFVYDVT KMTSFTNLKM WIQECNGHAV PPLVPKVLVG
160 170 180 190 200
NKCDLREQIQ VPSNLALKFA DAHNMLLFET SAKDPKESQN VESIFMCLAC
210 220 230
RLKAQKSLLY RDAERQQGKV QKLEFSQEAN GKASCPC
Length:237
Mass (Da):26,541
Last modified:May 1, 1997 - v1
Checksum:i6EF2E03B5E239930
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D83279 mRNA. Translation: BAA11883.1.
D83277 Genomic DNA. Translation: BAA11882.1.
CCDSiCCDS30110.1.
RefSeqiNP_035358.1. NM_011228.2.
UniGeneiMm.2015.

Genome annotation databases

EnsembliENSMUST00000033430; ENSMUSP00000033430; ENSMUSG00000031104.
GeneIDi19337.
KEGGimmu:19337.
UCSCiuc009tci.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D83279 mRNA. Translation: BAA11883.1.
D83277 Genomic DNA. Translation: BAA11882.1.
CCDSiCCDS30110.1.
RefSeqiNP_035358.1. NM_011228.2.
UniGeneiMm.2015.

3D structure databases

ProteinModelPortaliP97950.
SMRiP97950. Positions 35-199.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP97950. 9 interactions.
STRINGi10090.ENSMUSP00000033430.

PTM databases

iPTMnetiP97950.
PhosphoSiteiP97950.

Proteomic databases

PaxDbiP97950.
PeptideAtlasiP97950.
PRIDEiP97950.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033430; ENSMUSP00000033430; ENSMUSG00000031104.
GeneIDi19337.
KEGGimmu:19337.
UCSCiuc009tci.2. mouse.

Organism-specific databases

CTDi9363.
MGIiMGI:109493. Rab33a.

Phylogenomic databases

eggNOGiKOG0084. Eukaryota.
ENOG410XQN5. LUCA.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiP97950.
KOiK07919.
OMAiTWIEECN.
OrthoDBiEOG78PVB5.
PhylomeDBiP97950.
TreeFamiTF300097.

Miscellaneous databases

PROiP97950.
SOURCEiSearch...

Gene expression databases

BgeeiP97950.
CleanExiMM_RAB33A.
ExpressionAtlasiP97950. baseline and differential.
GenevisibleiP97950. MM.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiRB33A_MOUSE
AccessioniPrimary (citable) accession number: P97950
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: July 6, 2016
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.