Vascular endothelial growth factor D precursor

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Reviewed, UniProtKB/Swiss-Prot P97946 (VEGFD_MOUSE)

Last modified June 16, 2009. Version 74. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
    Vascular endothelial growth factor D
      Short name=VEGF-D
Alternative name(s):
    c-fos-induced growth factor
      Short name=FIGF

Gene names

Name:	Figf
Synonyms:	Vegfd

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

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Protein attributes

Sequence length	358 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

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General annotation (Comments)

Function	Growth factor active in angiogenesis, lymphangiogenesis and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in the formation of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-3 (Flt4) receptor.
Subunit structure	Homodimer; non-covalent and antiparallel.
Subcellular location	Secreted.
Tissue specificity	Highly expressed in fetal and adult lung.
Developmental stage	Expressed in a dynamic pattern in several body structures and organs of the embryo such as limb buds, acoustic ganglion, teeth, heart, anterior pituitary as well as lung and kidney mesenchyme, liver, derma, and periosteum of the vertebral column. Ref.4
Induction	By the transcription factor c-fos.
Post-translational modification	Undergoes a complex proteolytic maturation which generates a variety of processed secreted forms with increased activity toward VEGFR-3 and VEGFR-2. VEGF-D first form an antiparallel homodimer linked by disulfide bonds before secretion. The fully processed VEGF-D is composed mostly of two VEGF homology domains (VHDs) bound by non-covalent interactions By similarity.
Sequence similarities	Belongs to the PDGF/VEGF growth factor family.

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Ontologies

Keywords
Biological process	Angiogenesis Differentiation
Cellular component	Secreted
Domain	Repeat Signal
Molecular function	Developmental protein Growth factor Mitogen
PTM	Cleavage on pair of basic residues Disulfide bond Glycoprotein
Gene Ontology (GO)
Biological process	angiogenesis Inferred from electronic annotation. Source: UniProtKB-KW cell differentiation Inferred from electronic annotation. Source: UniProtKB-KW cell proliferation Ref.1 Inferred from direct assay. Source: MGI positive regulation of cell proliferation Inferred from direct assay. Source: MGI vascular endothelial growth factor receptor signaling pathway Inferred from genetic interaction. Source: MGI
Cellular component	extracellular space Inferred from direct assay. Source: MGI membrane Inferred from electronic annotation. Source: InterPro
Molecular function	growth factor activity Ref.1 Inferred from direct assay. Source: MGI protein homodimerization activity Ref.5 Inferred from physical interaction. Source: MGI vascular endothelial growth factor receptor 3 binding Ref.5 Inferred from direct assay. Source: MGI
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 21

Potential

Propeptide

22 – 93

Potential

PRO_0000023411

Chain

94 – 210

117

Vascular endothelial growth factor D

PRO_0000023412

Propeptide

211 – 358

148

Potential

PRO_0000023413

Regions

Repeat

227 – 242

1; approximate

Repeat

Repeat

Repeat

Region

4 X 16 AA repeats of C-X(10)-C-X-C-X(1,3)-C

Amino acid modifications

Glycosylation

160

N-linked (GlcNAc...) Potential

Glycosylation

190

N-linked (GlcNAc...) Potential

Glycosylation

292

N-linked (GlcNAc...) Potential

Disulfide bond

116 ↔ 158

By similarity

Disulfide bond

141

Interchain By similarity

Disulfide bond

147 ↔ 194

By similarity

Disulfide bond

150

Interchain By similarity

Disulfide bond

151 ↔ 196

By similarity

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Sequences

Sequence

Length

Mass (Da)

Tools

P97946-1 [UniParc].

Last modified May 1, 1997. Version 1.
Checksum: 6636B17FBF07037C
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FASTA

358

40,909

        10         20         30         40         50         60 
MYGEWGMGNI LMMFHVYLVQ GFRSEHGPVK DFSFERSSRS MLERSEQQIR AASSLEELLQ 

        70         80         90        100        110        120 
IAHSEDWKLW RCRLKLKSLA SMDSRSASHR STRFAATFYD TETLKVIDEE WQRTQCSPRE 

       130        140        150        160        170        180 
TCVEVASELG KTTNTFFKPP CVNVFRCGGC CNEEGVMCMN TSTSYISKQL FEISVPLTSV 

       190        200        210        220        230        240 
PELVPVKIAN HTGCKCLPTG PRHPYSIIRR SIQTPEEDEC PHSKKLCPID MLWDNTKCKC 

       250        260        270        280        290        300 
VLQDETPLPG TEDHSYLQEP TLCGPHMTFD EDRCECVCKA PCPGDLIQHP ENCSCFECKE 

       310        320        330        340        350 
SLESCCQKHK IFHPDTCSCE DRCPFHTRTC ASRKPACGKH WRFPKETRAQ GLYSQENP

« Hide

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of a c-fos-induced gene that is related to the platelet-derived growth factor/vascular endothelial growth factor family." Orlandini M., Marconcini L., Ferruzzi R., Oliviero S. Proc. Natl. Acad. Sci. U.S.A. 93:11675-11680(1996) [PubMed: 8876195] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: C57BL/6J. Tissue: Fibroblast.
[2]	"Molecular cloning of a novel vascular endothelial growth factor, VEGF-D." Yamada Y., Nezu J., Shimane M., Hirata Y. Genomics 42:483-488(1997) [PubMed: 9205122] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Lung.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Bone and Limb.
[4]	"Embryonic expression pattern of the murine figf gene, a growth factor belonging to platelet-derived growth factor/vascular endothelial growth factor family." Avantaggiato V., Orlandini M., Acampora D., Oliviero S., Simeone A. Mech. Dev. 73:221-224(1998) [PubMed: 9622638] [Abstract] Cited for: DEVELOPMENTAL STAGE.
[5]	"The specificity of receptor binding by vascular endothelial growth factor-d is different in mouse and man." Baldwin M.E., Catimel B., Nice E.C., Roufail S., Hall N.E., Stenvers K.L., Karkkainen M.J., Alitalo K., Stacker S.A., Achen M.G. J. Biol. Chem. 276:19166-19171(2001) [PubMed: 11279005] [Abstract] Cited for: RECEPTOR SPECIFICITY.
+	Additional computationally mapped references.

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Cross-references

Sequence databases
	X99572 mRNA. Translation: CAA67892.1. D89628 mRNA. Translation: BAA14002.1. BC080770 mRNA. Translation: AAH80770.1.
IPI	IPI00131038.
RefSeq	NP_034346.1.
UniGene	Mm.297978
3D structure databases
HSSP	HSSP built from PDB template 1PDG based on UniProtKB P01127.
ModBase	Search...
2-D gel databases
PMMA-2DPAGE	P97946.
Genome annotation databases
Ensembl	ENSMUSG00000031380. Mus musculus. [Contig view]
GeneID	14205.
KEGG	mmu:14205.
Organism-specific databases
MGI	MGI:108037. Figf.
Phylogenomic databases
HOGENOM	P97946.
HOVERGEN	P97946.
OMA	P97946. HSKKLCP.
Gene expression databases
ArrayExpress	P97946.
Bgee	P97946.
CleanEx	MM_FIGF.
GermOnline	ENSMUSG00000031380. Mus musculus.
Family and domain databases
InterPro	IPR004153. CXCXC_repeat. IPR000072. PD_growth_factor. [Graphical view]
Pfam	PF03128. CXCXC. 2 hits. PF00341. PDGF. 1 hit. [Graphical view]
ProDom	PD001629. PD_growth_factor. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00141. PDGF. 1 hit. [Graphical view]
PROSITE	PS00249. PDGF_1. 1 hit. PS50278. PDGF_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	285450.
SOURCE	Search...

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Entry information

Entry name

VEGFD_MOUSE

Accession

Primary (citable) accession number: P97946

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 16, 2001
Last sequence update:	May 1, 1997
Last modified:	June 16, 2009
This is version 74 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

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Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

2-D gel databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other Resources

Entry information

Relevant documents