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Protein

Vascular endothelial growth factor D

Gene

Vegfd

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Growth factor active in angiogenesis, lymphangiogenesis and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in the formation of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-3 (Flt4) receptor.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, Growth factor, Mitogen
Biological processAngiogenesis, Differentiation

Enzyme and pathway databases

ReactomeiR-MMU-114608 Platelet degranulation
R-MMU-194313 VEGF ligand-receptor interactions
R-MMU-195399 VEGF binds to VEGFR leading to receptor dimerization

Names & Taxonomyi

Protein namesi
Recommended name:
Vascular endothelial growth factor DImported
Short name:
VEGF-D
Alternative name(s):
c-Fos-induced growth factor
Short name:
FIGF
Gene namesi
Name:VegfdImported
Synonyms:Figf
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:108037 Vegfd

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
PropeptideiPRO_000002341122 – 93Sequence analysisAdd BLAST72
ChainiPRO_000002341294 – 210Vascular endothelial growth factor DAdd BLAST117
PropeptideiPRO_0000023413211 – 358Sequence analysisAdd BLAST148

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi116 ↔ 158By similarity
Disulfide bondi141InterchainBy similarity
Disulfide bondi147 ↔ 194By similarity
Disulfide bondi150InterchainBy similarity
Disulfide bondi151 ↔ 196By similarity
Glycosylationi160N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi190N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi292N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Undergoes a complex proteolytic maturation which generates a variety of processed secreted forms with increased activity toward VEGFR-3 and VEGFR-2. VEGF-D first form an antiparallel homodimer linked by disulfide bonds before secretion. The fully processed VEGF-D is composed mostly of two VEGF homology domains (VHDs) bound by non-covalent interactions (By similarity).By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP97946
PeptideAtlasiP97946
PRIDEiP97946

PTM databases

iPTMnetiP97946
PhosphoSitePlusiP97946

Expressioni

Tissue specificityi

Highly expressed in fetal and adult lung.

Developmental stagei

Expressed in a dynamic pattern in several body structures and organs of the embryo such as limb buds, acoustic ganglion, teeth, heart, anterior pituitary as well as lung and kidney mesenchyme, liver, derma, and periosteum of the vertebral column.1 Publication

Inductioni

By the transcription factor c-fos.

Gene expression databases

BgeeiENSMUSG00000031380
CleanExiMM_FIGF
GenevisibleiP97946 MM

Interactioni

Subunit structurei

Homodimer; non-covalent and antiparallel.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi199673, 2 interactors
STRINGi10090.ENSMUSP00000033751

Structurei

3D structure databases

ProteinModelPortaliP97946
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati227 – 2421; approximateAdd BLAST16
Repeati263 – 2782Add BLAST16
Repeati282 – 2983Add BLAST17
Repeati306 – 3234Add BLAST18

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni227 – 3234 X 16 AA repeats of C-X(10)-C-X-C-X(1,3)-CAdd BLAST97

Sequence similaritiesi

Belongs to the PDGF/VEGF growth factor family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IVDX Eukaryota
ENOG4111ICH LUCA
GeneTreeiENSGT00730000110889
HOGENOMiHOG000231512
HOVERGENiHBG073119
InParanoidiP97946
KOiK05449
OMAiCEDRCPF
OrthoDBiEOG091G07BT
PhylomeDBiP97946
TreeFamiTF319554

Family and domain databases

CDDicd00135 PDGF, 1 hit
Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR023581 PD_growth_factor_CS
IPR000072 PDGF/VEGF_dom
PfamiView protein in Pfam
PF00341 PDGF, 1 hit
SMARTiView protein in SMART
SM00141 PDGF, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00249 PDGF_1, 1 hit
PS50278 PDGF_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P97946-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYGEWGMGNI LMMFHVYLVQ GFRSEHGPVK DFSFERSSRS MLERSEQQIR
60 70 80 90 100
AASSLEELLQ IAHSEDWKLW RCRLKLKSLA SMDSRSASHR STRFAATFYD
110 120 130 140 150
TETLKVIDEE WQRTQCSPRE TCVEVASELG KTTNTFFKPP CVNVFRCGGC
160 170 180 190 200
CNEEGVMCMN TSTSYISKQL FEISVPLTSV PELVPVKIAN HTGCKCLPTG
210 220 230 240 250
PRHPYSIIRR SIQTPEEDEC PHSKKLCPID MLWDNTKCKC VLQDETPLPG
260 270 280 290 300
TEDHSYLQEP TLCGPHMTFD EDRCECVCKA PCPGDLIQHP ENCSCFECKE
310 320 330 340 350
SLESCCQKHK IFHPDTCSCE DRCPFHTRTC ASRKPACGKH WRFPKETRAQ

GLYSQENP
Length:358
Mass (Da):40,909
Last modified:May 1, 1997 - v1
Checksum:i6636B17FBF07037C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X99572 mRNA Translation: CAA67892.1
D89628 mRNA Translation: BAA14002.1
AL732475 Genomic DNA No translation available.
BC080770 mRNA Translation: AAH80770.1
CCDSiCCDS30521.1
RefSeqiNP_001295418.1, NM_001308489.1
NP_034346.1, NM_010216.2
XP_006528763.1, XM_006528700.3
UniGeneiMm.297978

Genome annotation databases

EnsembliENSMUST00000033751; ENSMUSP00000033751; ENSMUSG00000031380
GeneIDi14205
KEGGimmu:14205
UCSCiuc009uvm.1 mouse

Similar proteinsi

Entry informationi

Entry nameiVEGFD_MOUSE
AccessioniPrimary (citable) accession number: P97946
Secondary accession number(s): A2AIH3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: May 1, 1997
Last modified: May 23, 2018
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health