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P97946 (VEGFD_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 114. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Vascular endothelial growth factor D

Short name=VEGF-D
Alternative name(s):
c-Fos-induced growth factor
Short name=FIGF
Gene names
Name:Figf
Synonyms:Vegfd
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length358 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Growth factor active in angiogenesis, lymphangiogenesis and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in the formation of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-3 (Flt4) receptor.

Subunit structure

Homodimer; non-covalent and antiparallel.

Subcellular location

Secreted.

Tissue specificity

Highly expressed in fetal and adult lung.

Developmental stage

Expressed in a dynamic pattern in several body structures and organs of the embryo such as limb buds, acoustic ganglion, teeth, heart, anterior pituitary as well as lung and kidney mesenchyme, liver, derma, and periosteum of the vertebral column. Ref.5

Induction

By the transcription factor c-fos.

Post-translational modification

Undergoes a complex proteolytic maturation which generates a variety of processed secreted forms with increased activity toward VEGFR-3 and VEGFR-2. VEGF-D first form an antiparallel homodimer linked by disulfide bonds before secretion. The fully processed VEGF-D is composed mostly of two VEGF homology domains (VHDs) bound by non-covalent interactions By similarity.

Sequence similarities

Belongs to the PDGF/VEGF growth factor family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Propeptide22 – 9372 Potential
PRO_0000023411
Chain94 – 210117Vascular endothelial growth factor D
PRO_0000023412
Propeptide211 – 358148 Potential
PRO_0000023413

Regions

Repeat227 – 242161; approximate
Repeat263 – 278162
Repeat282 – 298173
Repeat306 – 323184
Region227 – 323974 X 16 AA repeats of C-X(10)-C-X-C-X(1,3)-C

Amino acid modifications

Glycosylation1601N-linked (GlcNAc...) Potential
Glycosylation1901N-linked (GlcNAc...) Potential
Glycosylation2921N-linked (GlcNAc...) Potential
Disulfide bond116 ↔ 158 By similarity
Disulfide bond141Interchain By similarity
Disulfide bond147 ↔ 194 By similarity
Disulfide bond150Interchain By similarity
Disulfide bond151 ↔ 196 By similarity

Sequences

Sequence LengthMass (Da)Tools
P97946 [UniParc].

Last modified May 1, 1997. Version 1.
Checksum: 6636B17FBF07037C

FASTA35840,909
        10         20         30         40         50         60 
MYGEWGMGNI LMMFHVYLVQ GFRSEHGPVK DFSFERSSRS MLERSEQQIR AASSLEELLQ 

        70         80         90        100        110        120 
IAHSEDWKLW RCRLKLKSLA SMDSRSASHR STRFAATFYD TETLKVIDEE WQRTQCSPRE 

       130        140        150        160        170        180 
TCVEVASELG KTTNTFFKPP CVNVFRCGGC CNEEGVMCMN TSTSYISKQL FEISVPLTSV 

       190        200        210        220        230        240 
PELVPVKIAN HTGCKCLPTG PRHPYSIIRR SIQTPEEDEC PHSKKLCPID MLWDNTKCKC 

       250        260        270        280        290        300 
VLQDETPLPG TEDHSYLQEP TLCGPHMTFD EDRCECVCKA PCPGDLIQHP ENCSCFECKE 

       310        320        330        340        350 
SLESCCQKHK IFHPDTCSCE DRCPFHTRTC ASRKPACGKH WRFPKETRAQ GLYSQENP 

« Hide

References

« Hide 'large scale' references
[1]"Identification of a c-fos-induced gene that is related to the platelet-derived growth factor/vascular endothelial growth factor family."
Orlandini M., Marconcini L., Ferruzzi R., Oliviero S.
Proc. Natl. Acad. Sci. U.S.A. 93:11675-11680(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6J.
Tissue: Fibroblast.
[2]"Molecular cloning of a novel vascular endothelial growth factor, VEGF-D."
Yamada Y., Nezu J., Shimane M., Hirata Y.
Genomics 42:483-488(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Lung.
[3]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Bone and Limb.
[5]"Embryonic expression pattern of the murine figf gene, a growth factor belonging to platelet-derived growth factor/vascular endothelial growth factor family."
Avantaggiato V., Orlandini M., Acampora D., Oliviero S., Simeone A.
Mech. Dev. 73:221-224(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: DEVELOPMENTAL STAGE.
[6]"The specificity of receptor binding by vascular endothelial growth factor-d is different in mouse and man."
Baldwin M.E., Catimel B., Nice E.C., Roufail S., Hall N.E., Stenvers K.L., Karkkainen M.J., Alitalo K., Stacker S.A., Achen M.G.
J. Biol. Chem. 276:19166-19171(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: RECEPTOR SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X99572 mRNA. Translation: CAA67892.1.
D89628 mRNA. Translation: BAA14002.1.
AL732475 Genomic DNA. Translation: CAM17370.1.
BC080770 mRNA. Translation: AAH80770.1.
RefSeqNP_034346.1. NM_010216.1.
XP_006528763.1. XM_006528700.1.
UniGeneMm.297978.

3D structure databases

ProteinModelPortalP97946.
SMRP97946. Positions 37-199.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid199673. 2 interactions.
STRING10090.ENSMUSP00000033751.

PTM databases

PhosphoSiteP97946.

Proteomic databases

PRIDEP97946.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000033751; ENSMUSP00000033751; ENSMUSG00000031380.
GeneID14205.
KEGGmmu:14205.
UCSCuc009uvm.1. mouse.

Organism-specific databases

CTD2277.
MGIMGI:108037. Figf.

Phylogenomic databases

eggNOGNOG77707.
GeneTreeENSGT00730000110889.
HOGENOMHOG000231512.
HOVERGENHBG073119.
InParanoidA2AIH3.
KOK05449.
OMADTCSCED.
OrthoDBEOG7J17ZS.
TreeFamTF319554.

Gene expression databases

BgeeP97946.
CleanExMM_FIGF.
GenevestigatorP97946.

Family and domain databases

InterProIPR023581. PD_growth_factor_CS.
IPR000072. PDGF/VEGF_dom.
[Graphical view]
PfamPF00341. PDGF. 1 hit.
[Graphical view]
SMARTSM00141. PDGF. 1 hit.
[Graphical view]
PROSITEPS00249. PDGF_1. 1 hit.
PS50278. PDGF_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio285450.
PROP97946.
SOURCESearch...

Entry information

Entry nameVEGFD_MOUSE
AccessionPrimary (citable) accession number: P97946
Secondary accession number(s): A2AIH3
Entry history
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: May 1, 1997
Last modified: March 19, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot