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P97946

- VEGFD_MOUSE

UniProt

P97946 - VEGFD_MOUSE

Protein

Vascular endothelial growth factor D

Gene

Figf

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 119 (01 Oct 2014)
      Sequence version 1 (01 May 1997)
      Previous versions | rss
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    Functioni

    Growth factor active in angiogenesis, lymphangiogenesis and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in the formation of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-3 (Flt4) receptor.

    GO - Molecular functioni

    1. chemoattractant activity Source: Ensembl
    2. growth factor activity Source: MGI
    3. protein binding Source: MGI
    4. protein homodimerization activity Source: MGI
    5. vascular endothelial growth factor receptor 3 binding Source: MGI

    GO - Biological processi

    1. angiogenesis Source: UniProtKB-KW
    2. cell differentiation Source: UniProtKB-KW
    3. cell proliferation Source: MGI
    4. induction of positive chemotaxis Source: Ensembl
    5. positive regulation of cell division Source: UniProtKB-KW
    6. positive regulation of cell proliferation Source: MGI
    7. positive regulation of mast cell chemotaxis Source: Ensembl
    8. vascular endothelial growth factor receptor signaling pathway Source: MGI

    Keywords - Molecular functioni

    Developmental protein, Growth factor, Mitogen

    Keywords - Biological processi

    Angiogenesis, Differentiation

    Enzyme and pathway databases

    ReactomeiREACT_205099. VEGF binds to VEGFR leading to receptor dimerization.
    REACT_224551. VEGF ligand-receptor interactions.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Vascular endothelial growth factor D
    Short name:
    VEGF-D
    Alternative name(s):
    c-Fos-induced growth factor
    Short name:
    FIGF
    Gene namesi
    Name:Figf
    Synonyms:Vegfd
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome X

    Organism-specific databases

    MGIiMGI:108037. Figf.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: MGI
    2. extracellular space Source: MGI
    3. membrane Source: InterPro

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Propeptidei22 – 9372Sequence AnalysisPRO_0000023411Add
    BLAST
    Chaini94 – 210117Vascular endothelial growth factor DPRO_0000023412Add
    BLAST
    Propeptidei211 – 358148Sequence AnalysisPRO_0000023413Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi116 ↔ 158By similarity
    Disulfide bondi141 – 141InterchainBy similarity
    Disulfide bondi147 ↔ 194By similarity
    Disulfide bondi150 – 150InterchainBy similarity
    Disulfide bondi151 ↔ 196By similarity
    Glycosylationi160 – 1601N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi190 – 1901N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi292 – 2921N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    Undergoes a complex proteolytic maturation which generates a variety of processed secreted forms with increased activity toward VEGFR-3 and VEGFR-2. VEGF-D first form an antiparallel homodimer linked by disulfide bonds before secretion. The fully processed VEGF-D is composed mostly of two VEGF homology domains (VHDs) bound by non-covalent interactions By similarity.By similarity

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiP97946.

    PTM databases

    PhosphoSiteiP97946.

    Expressioni

    Tissue specificityi

    Highly expressed in fetal and adult lung.

    Developmental stagei

    Expressed in a dynamic pattern in several body structures and organs of the embryo such as limb buds, acoustic ganglion, teeth, heart, anterior pituitary as well as lung and kidney mesenchyme, liver, derma, and periosteum of the vertebral column.1 Publication

    Inductioni

    By the transcription factor c-fos.

    Gene expression databases

    BgeeiP97946.
    CleanExiMM_FIGF.
    GenevestigatoriP97946.

    Interactioni

    Subunit structurei

    Homodimer; non-covalent and antiparallel.

    Protein-protein interaction databases

    BioGridi199673. 2 interactions.
    STRINGi10090.ENSMUSP00000033751.

    Structurei

    3D structure databases

    ProteinModelPortaliP97946.
    SMRiP97946. Positions 97-199.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati227 – 242161; approximateAdd
    BLAST
    Repeati263 – 278162Add
    BLAST
    Repeati282 – 298173Add
    BLAST
    Repeati306 – 323184Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni227 – 323974 X 16 AA repeats of C-X(10)-C-X-C-X(1,3)-CAdd
    BLAST

    Sequence similaritiesi

    Belongs to the PDGF/VEGF growth factor family.Curated

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG77707.
    GeneTreeiENSGT00730000110889.
    HOGENOMiHOG000231512.
    HOVERGENiHBG073119.
    InParanoidiA2AIH3.
    KOiK05449.
    OMAiDTCSCED.
    OrthoDBiEOG7J17ZS.
    PhylomeDBiP97946.
    TreeFamiTF319554.

    Family and domain databases

    Gene3Di2.10.90.10. 1 hit.
    InterProiIPR029034. Cystine-knot_cytokine.
    IPR023581. PD_growth_factor_CS.
    IPR000072. PDGF/VEGF_dom.
    [Graphical view]
    PfamiPF00341. PDGF. 1 hit.
    [Graphical view]
    SMARTiSM00141. PDGF. 1 hit.
    [Graphical view]
    SUPFAMiSSF57501. SSF57501. 1 hit.
    PROSITEiPS00249. PDGF_1. 1 hit.
    PS50278. PDGF_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P97946-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYGEWGMGNI LMMFHVYLVQ GFRSEHGPVK DFSFERSSRS MLERSEQQIR    50
    AASSLEELLQ IAHSEDWKLW RCRLKLKSLA SMDSRSASHR STRFAATFYD 100
    TETLKVIDEE WQRTQCSPRE TCVEVASELG KTTNTFFKPP CVNVFRCGGC 150
    CNEEGVMCMN TSTSYISKQL FEISVPLTSV PELVPVKIAN HTGCKCLPTG 200
    PRHPYSIIRR SIQTPEEDEC PHSKKLCPID MLWDNTKCKC VLQDETPLPG 250
    TEDHSYLQEP TLCGPHMTFD EDRCECVCKA PCPGDLIQHP ENCSCFECKE 300
    SLESCCQKHK IFHPDTCSCE DRCPFHTRTC ASRKPACGKH WRFPKETRAQ 350
    GLYSQENP 358
    Length:358
    Mass (Da):40,909
    Last modified:May 1, 1997 - v1
    Checksum:i6636B17FBF07037C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X99572 mRNA. Translation: CAA67892.1.
    D89628 mRNA. Translation: BAA14002.1.
    AL732475 Genomic DNA. Translation: CAM17370.1.
    BC080770 mRNA. Translation: AAH80770.1.
    CCDSiCCDS30521.1.
    RefSeqiNP_034346.1. NM_010216.1.
    XP_006528763.1. XM_006528700.1.
    UniGeneiMm.297978.

    Genome annotation databases

    EnsembliENSMUST00000033751; ENSMUSP00000033751; ENSMUSG00000031380.
    GeneIDi14205.
    KEGGimmu:14205.
    UCSCiuc009uvm.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X99572 mRNA. Translation: CAA67892.1 .
    D89628 mRNA. Translation: BAA14002.1 .
    AL732475 Genomic DNA. Translation: CAM17370.1 .
    BC080770 mRNA. Translation: AAH80770.1 .
    CCDSi CCDS30521.1.
    RefSeqi NP_034346.1. NM_010216.1.
    XP_006528763.1. XM_006528700.1.
    UniGenei Mm.297978.

    3D structure databases

    ProteinModelPortali P97946.
    SMRi P97946. Positions 97-199.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 199673. 2 interactions.
    STRINGi 10090.ENSMUSP00000033751.

    PTM databases

    PhosphoSitei P97946.

    Proteomic databases

    PRIDEi P97946.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000033751 ; ENSMUSP00000033751 ; ENSMUSG00000031380 .
    GeneIDi 14205.
    KEGGi mmu:14205.
    UCSCi uc009uvm.1. mouse.

    Organism-specific databases

    CTDi 2277.
    MGIi MGI:108037. Figf.

    Phylogenomic databases

    eggNOGi NOG77707.
    GeneTreei ENSGT00730000110889.
    HOGENOMi HOG000231512.
    HOVERGENi HBG073119.
    InParanoidi A2AIH3.
    KOi K05449.
    OMAi DTCSCED.
    OrthoDBi EOG7J17ZS.
    PhylomeDBi P97946.
    TreeFami TF319554.

    Enzyme and pathway databases

    Reactomei REACT_205099. VEGF binds to VEGFR leading to receptor dimerization.
    REACT_224551. VEGF ligand-receptor interactions.

    Miscellaneous databases

    NextBioi 285450.
    PROi P97946.
    SOURCEi Search...

    Gene expression databases

    Bgeei P97946.
    CleanExi MM_FIGF.
    Genevestigatori P97946.

    Family and domain databases

    Gene3Di 2.10.90.10. 1 hit.
    InterProi IPR029034. Cystine-knot_cytokine.
    IPR023581. PD_growth_factor_CS.
    IPR000072. PDGF/VEGF_dom.
    [Graphical view ]
    Pfami PF00341. PDGF. 1 hit.
    [Graphical view ]
    SMARTi SM00141. PDGF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57501. SSF57501. 1 hit.
    PROSITEi PS00249. PDGF_1. 1 hit.
    PS50278. PDGF_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a c-fos-induced gene that is related to the platelet-derived growth factor/vascular endothelial growth factor family."
      Orlandini M., Marconcini L., Ferruzzi R., Oliviero S.
      Proc. Natl. Acad. Sci. U.S.A. 93:11675-11680(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6J.
      Tissue: Fibroblast.
    2. "Molecular cloning of a novel vascular endothelial growth factor, VEGF-D."
      Yamada Y., Nezu J., Shimane M., Hirata Y.
      Genomics 42:483-488(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Lung.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Bone and Limb.
    5. "Embryonic expression pattern of the murine figf gene, a growth factor belonging to platelet-derived growth factor/vascular endothelial growth factor family."
      Avantaggiato V., Orlandini M., Acampora D., Oliviero S., Simeone A.
      Mech. Dev. 73:221-224(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: DEVELOPMENTAL STAGE.
    6. "The specificity of receptor binding by vascular endothelial growth factor-d is different in mouse and man."
      Baldwin M.E., Catimel B., Nice E.C., Roufail S., Hall N.E., Stenvers K.L., Karkkainen M.J., Alitalo K., Stacker S.A., Achen M.G.
      J. Biol. Chem. 276:19166-19171(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: RECEPTOR SPECIFICITY.

    Entry informationi

    Entry nameiVEGFD_MOUSE
    AccessioniPrimary (citable) accession number: P97946
    Secondary accession number(s): A2AIH3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 16, 2001
    Last sequence update: May 1, 1997
    Last modified: October 1, 2014
    This is version 119 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3