Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Vascular endothelial growth factor D

Gene

Figf

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Growth factor active in angiogenesis, lymphangiogenesis and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in the formation of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-3 (Flt4) receptor.

GO - Molecular functioni

  • chemoattractant activity Source: MGI
  • growth factor activity Source: MGI
  • protein homodimerization activity Source: MGI
  • vascular endothelial growth factor receptor 3 binding Source: MGI
  • vascular endothelial growth factor receptor binding Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Growth factor, Mitogen

Keywords - Biological processi

Angiogenesis, Differentiation

Enzyme and pathway databases

ReactomeiREACT_293283. VEGF binds to VEGFR leading to receptor dimerization.
REACT_307071. Platelet degranulation.
REACT_343634. VEGF ligand-receptor interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Vascular endothelial growth factor D
Short name:
VEGF-D
Alternative name(s):
c-Fos-induced growth factor
Short name:
FIGF
Gene namesi
Name:Figf
Synonyms:Vegfd
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:108037. Figf.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: MGI
  • extracellular space Source: MGI
  • membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Propeptidei22 – 9372Sequence AnalysisPRO_0000023411Add
BLAST
Chaini94 – 210117Vascular endothelial growth factor DPRO_0000023412Add
BLAST
Propeptidei211 – 358148Sequence AnalysisPRO_0000023413Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi116 ↔ 158By similarity
Disulfide bondi141 – 141InterchainBy similarity
Disulfide bondi147 ↔ 194By similarity
Disulfide bondi150 – 150InterchainBy similarity
Disulfide bondi151 ↔ 196By similarity
Glycosylationi160 – 1601N-linked (GlcNAc...)Sequence Analysis
Glycosylationi190 – 1901N-linked (GlcNAc...)Sequence Analysis
Glycosylationi292 – 2921N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

Undergoes a complex proteolytic maturation which generates a variety of processed secreted forms with increased activity toward VEGFR-3 and VEGFR-2. VEGF-D first form an antiparallel homodimer linked by disulfide bonds before secretion. The fully processed VEGF-D is composed mostly of two VEGF homology domains (VHDs) bound by non-covalent interactions (By similarity).By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP97946.

PTM databases

PhosphoSiteiP97946.

Expressioni

Tissue specificityi

Highly expressed in fetal and adult lung.

Developmental stagei

Expressed in a dynamic pattern in several body structures and organs of the embryo such as limb buds, acoustic ganglion, teeth, heart, anterior pituitary as well as lung and kidney mesenchyme, liver, derma, and periosteum of the vertebral column.1 Publication

Inductioni

By the transcription factor c-fos.

Gene expression databases

BgeeiP97946.
CleanExiMM_FIGF.
GenevisibleiP97946. MM.

Interactioni

Subunit structurei

Homodimer; non-covalent and antiparallel.

Protein-protein interaction databases

BioGridi199673. 2 interactions.
STRINGi10090.ENSMUSP00000033751.

Structurei

3D structure databases

ProteinModelPortaliP97946.
SMRiP97946. Positions 97-199.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati227 – 242161; approximateAdd
BLAST
Repeati263 – 278162Add
BLAST
Repeati282 – 298173Add
BLAST
Repeati306 – 323184Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni227 – 323974 X 16 AA repeats of C-X(10)-C-X-C-X(1,3)-CAdd
BLAST

Sequence similaritiesi

Belongs to the PDGF/VEGF growth factor family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG77707.
GeneTreeiENSGT00730000110889.
HOGENOMiHOG000231512.
HOVERGENiHBG073119.
InParanoidiP97946.
KOiK05449.
OMAiDTCSCED.
OrthoDBiEOG7J17ZS.
PhylomeDBiP97946.
TreeFamiTF319554.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR023581. PD_growth_factor_CS.
IPR000072. PDGF/VEGF_dom.
[Graphical view]
PfamiPF00341. PDGF. 1 hit.
[Graphical view]
SMARTiSM00141. PDGF. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00249. PDGF_1. 1 hit.
PS50278. PDGF_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P97946-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYGEWGMGNI LMMFHVYLVQ GFRSEHGPVK DFSFERSSRS MLERSEQQIR
60 70 80 90 100
AASSLEELLQ IAHSEDWKLW RCRLKLKSLA SMDSRSASHR STRFAATFYD
110 120 130 140 150
TETLKVIDEE WQRTQCSPRE TCVEVASELG KTTNTFFKPP CVNVFRCGGC
160 170 180 190 200
CNEEGVMCMN TSTSYISKQL FEISVPLTSV PELVPVKIAN HTGCKCLPTG
210 220 230 240 250
PRHPYSIIRR SIQTPEEDEC PHSKKLCPID MLWDNTKCKC VLQDETPLPG
260 270 280 290 300
TEDHSYLQEP TLCGPHMTFD EDRCECVCKA PCPGDLIQHP ENCSCFECKE
310 320 330 340 350
SLESCCQKHK IFHPDTCSCE DRCPFHTRTC ASRKPACGKH WRFPKETRAQ

GLYSQENP
Length:358
Mass (Da):40,909
Last modified:May 1, 1997 - v1
Checksum:i6636B17FBF07037C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X99572 mRNA. Translation: CAA67892.1.
D89628 mRNA. Translation: BAA14002.1.
AL732475 Genomic DNA. Translation: CAM17370.1.
BC080770 mRNA. Translation: AAH80770.1.
CCDSiCCDS30521.1.
RefSeqiNP_034346.1. NM_010216.2.
XP_006528763.1. XM_006528700.2.
UniGeneiMm.297978.

Genome annotation databases

EnsembliENSMUST00000033751; ENSMUSP00000033751; ENSMUSG00000031380.
GeneIDi14205.
KEGGimmu:14205.
UCSCiuc009uvm.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X99572 mRNA. Translation: CAA67892.1.
D89628 mRNA. Translation: BAA14002.1.
AL732475 Genomic DNA. Translation: CAM17370.1.
BC080770 mRNA. Translation: AAH80770.1.
CCDSiCCDS30521.1.
RefSeqiNP_034346.1. NM_010216.2.
XP_006528763.1. XM_006528700.2.
UniGeneiMm.297978.

3D structure databases

ProteinModelPortaliP97946.
SMRiP97946. Positions 97-199.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199673. 2 interactions.
STRINGi10090.ENSMUSP00000033751.

PTM databases

PhosphoSiteiP97946.

Proteomic databases

PRIDEiP97946.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033751; ENSMUSP00000033751; ENSMUSG00000031380.
GeneIDi14205.
KEGGimmu:14205.
UCSCiuc009uvm.1. mouse.

Organism-specific databases

CTDi2277.
MGIiMGI:108037. Figf.

Phylogenomic databases

eggNOGiNOG77707.
GeneTreeiENSGT00730000110889.
HOGENOMiHOG000231512.
HOVERGENiHBG073119.
InParanoidiP97946.
KOiK05449.
OMAiDTCSCED.
OrthoDBiEOG7J17ZS.
PhylomeDBiP97946.
TreeFamiTF319554.

Enzyme and pathway databases

ReactomeiREACT_293283. VEGF binds to VEGFR leading to receptor dimerization.
REACT_307071. Platelet degranulation.
REACT_343634. VEGF ligand-receptor interactions.

Miscellaneous databases

NextBioi285450.
PROiP97946.
SOURCEiSearch...

Gene expression databases

BgeeiP97946.
CleanExiMM_FIGF.
GenevisibleiP97946. MM.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR023581. PD_growth_factor_CS.
IPR000072. PDGF/VEGF_dom.
[Graphical view]
PfamiPF00341. PDGF. 1 hit.
[Graphical view]
SMARTiSM00141. PDGF. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00249. PDGF_1. 1 hit.
PS50278. PDGF_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a c-fos-induced gene that is related to the platelet-derived growth factor/vascular endothelial growth factor family."
    Orlandini M., Marconcini L., Ferruzzi R., Oliviero S.
    Proc. Natl. Acad. Sci. U.S.A. 93:11675-11680(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
    Tissue: Fibroblast.
  2. "Molecular cloning of a novel vascular endothelial growth factor, VEGF-D."
    Yamada Y., Nezu J., Shimane M., Hirata Y.
    Genomics 42:483-488(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Lung.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Bone and Limb.
  5. "Embryonic expression pattern of the murine figf gene, a growth factor belonging to platelet-derived growth factor/vascular endothelial growth factor family."
    Avantaggiato V., Orlandini M., Acampora D., Oliviero S., Simeone A.
    Mech. Dev. 73:221-224(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: DEVELOPMENTAL STAGE.
  6. "The specificity of receptor binding by vascular endothelial growth factor-d is different in mouse and man."
    Baldwin M.E., Catimel B., Nice E.C., Roufail S., Hall N.E., Stenvers K.L., Karkkainen M.J., Alitalo K., Stacker S.A., Achen M.G.
    J. Biol. Chem. 276:19166-19171(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: RECEPTOR SPECIFICITY.

Entry informationi

Entry nameiVEGFD_MOUSE
AccessioniPrimary (citable) accession number: P97946
Secondary accession number(s): A2AIH3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: May 1, 1997
Last modified: July 22, 2015
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.