Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Scavenger receptor class B member 1

Gene

Scarb1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Probable receptor for HDL, located in particular region of the plasma membrane, called caveolae. Facilitates the flux of free and esterified cholesterol between the cell surface and extracellular donors and acceptors, such as HDL and to a lesser extent, apoB-containing lipoproteins and modified lipoproteins. Probably involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity (By similarity). Plays an important role in the uptake of HDL cholesteryl ester.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiR-RNO-194223. HDL-mediated lipid transport.
R-RNO-3000471. Scavenging by Class B Receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Scavenger receptor class B member 1
Short name:
SRB1
Alternative name(s):
SR-BI
Gene namesi
Name:Scarb1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 12

Organism-specific databases

RGDi2302. Scarb1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1111CytoplasmicSequence analysisAdd
BLAST
Transmembranei12 – 3221HelicalSequence analysisAdd
BLAST
Topological domaini33 – 440408ExtracellularSequence analysisAdd
BLAST
Transmembranei441 – 46121HelicalSequence analysisAdd
BLAST
Topological domaini462 – 50948CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • caveola Source: UniProtKB-SubCell
  • cell surface Source: RGD
  • cytoplasm Source: RGD
  • extracellular exosome Source: Ensembl
  • integral component of plasma membrane Source: Ensembl
  • lysosomal membrane Source: Ensembl
  • microvillus membrane Source: RGD
  • plasma membrane Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 509509Scavenger receptor class B member 1PRO_0000144163Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi102 – 1021N-linked (GlcNAc...)Sequence analysis
Glycosylationi108 – 1081N-linked (GlcNAc...)Sequence analysis
Glycosylationi116 – 1161N-linked (GlcNAc...)Sequence analysis
Glycosylationi173 – 1731N-linked (GlcNAc...)Sequence analysis
Glycosylationi212 – 2121N-linked (GlcNAc...)Sequence analysis
Glycosylationi227 – 2271N-linked (GlcNAc...)Sequence analysis
Disulfide bondi251 ↔ 384By similarity
Glycosylationi255 – 2551N-linked (GlcNAc...)Sequence analysis
Glycosylationi310 – 3101N-linked (GlcNAc...)Sequence analysis
Glycosylationi330 – 3301N-linked (GlcNAc...)Sequence analysis
Glycosylationi383 – 3831N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

N-glycosylated.1 Publication
The six cysteines of the extracellular domain are all involved in intramolecular disulfide bonds.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP97943.
PRIDEiP97943.

PTM databases

iPTMnetiP97943.
PhosphoSiteiP97943.

Expressioni

Gene expression databases

BgeeiENSRNOG00000000981.
ExpressionAtlasiP97943. baseline and differential.
GenevisibleiP97943. RN.

Interactioni

Subunit structurei

The C-terminal region binds to PDZK1.1 Publication

GO - Molecular functioni

  • protein homodimerization activity Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000060874.

Family & Domainsi

Sequence similaritiesi

Belongs to the CD36 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3776. Eukaryota.
ENOG410XS17. LUCA.
GeneTreeiENSGT00530000062927.
HOGENOMiHOG000252951.
HOVERGENiHBG106577.
InParanoidiP97943.
KOiK13885.
OMAiMWKEIPI.
OrthoDBiEOG091G0CH9.
PhylomeDBiP97943.
TreeFamiTF317925.

Family and domain databases

InterProiIPR005428. CD36/SCARB1/SNMP1.
IPR002159. CD36_fam.
[Graphical view]
PANTHERiPTHR11923. PTHR11923. 1 hit.
PfamiPF01130. CD36. 1 hit.
[Graphical view]
PRINTSiPR01610. CD36ANTIGEN.
PR01609. CD36FAMILY.

Sequencei

Sequence statusi: Complete.

P97943-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGVSSRARWV ALGLGVLGLL CAALGVIMIL MVPSLIKQQV LKNVRIDPSS
60 70 80 90 100
LSFGMWKEIP VPFYLSVYFF EVVNPSEVLN GQKPVVRERG PYVYREFRQK
110 120 130 140 150
VNITFNDNDT VSYIENRSLR FQPDRSQGSE SDYIVLPNIL VLGGAVMMED
160 170 180 190 200
KPTSLKLLMT LGLVTMGQRA FMNRTVGEIL WGYEDPFVNF LSKYFPDMFP
210 220 230 240 250
IKGKFGLFVG MNDSSSGVFT VFTGVQNFSK IHLVDKWNGL SEVNYWHSEQ
260 270 280 290 300
CNMINGTAGQ MWAPFMTPES SLEFFSPEAC RSMKLTYQES RVFEGIPTYR
310 320 330 340 350
FTAPDTLFAN GSVYPPNEGF CPCRESGIQN VSTCRFGAPL FLSQPHFYNA
360 370 380 390 400
DPVLSEAVLG LNPDPKEHSL FLDIHPVTGI PMNCSVKMQL SLYIKSVKGV
410 420 430 440 450
GQTGKIEPVV LPLLWFEQSG MMGGKTLNTF YTQLVLMPQV LHYAQYVLLG
460 470 480 490 500
LGGLLLLVPI IYQLRSQEKC FLFWSGSKKG SQDKEAMQAY SESLMSPAAK

GTVLQEAKL
Length:509
Mass (Da):56,957
Last modified:May 1, 1997 - v1
Checksum:i792A0BBE8D11A105
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U76205 mRNA. Translation: AAB19203.1.
D89655 mRNA. Translation: BAA14004.1.
AB002151 mRNA. Translation: BAA74541.1.
BC076504 mRNA. Translation: AAH76504.1.
PIRiJC5533.
RefSeqiNP_113729.1. NM_031541.1.
UniGeneiRn.88169.

Genome annotation databases

EnsembliENSRNOT00000064276; ENSRNOP00000060874; ENSRNOG00000000981.
GeneIDi25073.
KEGGirno:25073.
UCSCiRGD:2302. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U76205 mRNA. Translation: AAB19203.1.
D89655 mRNA. Translation: BAA14004.1.
AB002151 mRNA. Translation: BAA74541.1.
BC076504 mRNA. Translation: AAH76504.1.
PIRiJC5533.
RefSeqiNP_113729.1. NM_031541.1.
UniGeneiRn.88169.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000060874.

PTM databases

iPTMnetiP97943.
PhosphoSiteiP97943.

Proteomic databases

PaxDbiP97943.
PRIDEiP97943.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000064276; ENSRNOP00000060874; ENSRNOG00000000981.
GeneIDi25073.
KEGGirno:25073.
UCSCiRGD:2302. rat.

Organism-specific databases

CTDi949.
RGDi2302. Scarb1.

Phylogenomic databases

eggNOGiKOG3776. Eukaryota.
ENOG410XS17. LUCA.
GeneTreeiENSGT00530000062927.
HOGENOMiHOG000252951.
HOVERGENiHBG106577.
InParanoidiP97943.
KOiK13885.
OMAiMWKEIPI.
OrthoDBiEOG091G0CH9.
PhylomeDBiP97943.
TreeFamiTF317925.

Enzyme and pathway databases

ReactomeiR-RNO-194223. HDL-mediated lipid transport.
R-RNO-3000471. Scavenging by Class B Receptors.

Miscellaneous databases

PROiP97943.

Gene expression databases

BgeeiENSRNOG00000000981.
ExpressionAtlasiP97943. baseline and differential.
GenevisibleiP97943. RN.

Family and domain databases

InterProiIPR005428. CD36/SCARB1/SNMP1.
IPR002159. CD36_fam.
[Graphical view]
PANTHERiPTHR11923. PTHR11923. 1 hit.
PfamiPF01130. CD36. 1 hit.
[Graphical view]
PRINTSiPR01610. CD36ANTIGEN.
PR01609. CD36FAMILY.
ProtoNetiSearch...

Entry informationi

Entry nameiSCRB1_RAT
AccessioniPrimary (citable) accession number: P97943
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: May 1, 1997
Last modified: September 7, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.