Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P97930

- KTHY_MOUSE

UniProt

P97930 - KTHY_MOUSE

Protein

Thymidylate kinase

Gene

Dtymk

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 2 (01 Jul 2008)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalyzes the conversion of dTMP to dTDP.

    Catalytic activityi

    ATP + dTMP = ADP + dTDP.

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi13 – 208ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. nucleoside phosphate kinase activity Source: Ensembl
    3. thymidylate kinase activity Source: MGI

    GO - Biological processi

    1. cellular response to growth factor stimulus Source: MGI
    2. dTDP biosynthetic process Source: MGI
    3. dTTP biosynthetic process Source: UniProtKB-UniPathway
    4. myoblast differentiation Source: Ensembl
    5. nucleotide biosynthetic process Source: MGI
    6. nucleotide phosphorylation Source: GOC
    7. response to cadmium ion Source: Ensembl
    8. response to estrogen Source: Ensembl

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Nucleotide biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    SABIO-RKP97930.
    UniPathwayiUPA00575.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymidylate kinase (EC:2.7.4.9)
    Alternative name(s):
    dTMP kinase
    Gene namesi
    Name:Dtymk
    Synonyms:Tmk
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:108396. Dtymk.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrial intermembrane space Source: Ensembl
    2. mitochondrial matrix Source: Ensembl

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 212211Thymidylate kinasePRO_0000155211Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiP97930.
    PaxDbiP97930.
    PRIDEiP97930.

    PTM databases

    PhosphoSiteiP97930.

    Expressioni

    Gene expression databases

    ArrayExpressiP97930.
    BgeeiP97930.
    CleanExiMM_DTYMK.
    GenevestigatoriP97930.

    Interactioni

    Protein-protein interaction databases

    BioGridi204232. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliP97930.
    SMRiP97930. Positions 4-212.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thymidylate kinase family.Curated

    Phylogenomic databases

    eggNOGiCOG0125.
    GeneTreeiENSGT00390000017546.
    HOGENOMiHOG000229079.
    HOVERGENiHBG051418.
    KOiK00943.
    OMAiGKMIDSY.
    OrthoDBiEOG7WQ7T8.
    TreeFamiTF324638.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    HAMAPiMF_00165. Thymidylate_kinase.
    InterProiIPR027417. P-loop_NTPase.
    IPR018095. Thymidylate_kin_CS.
    IPR018094. Thymidylate_kinase.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00041. DTMP_kinase. 1 hit.
    PROSITEiPS01331. THYMIDYLATE_KINASE. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform Long (identifier: P97930-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MASRRGALIV LEGVDRAGKT TQGLKLVTAL CASGHRAELL RFPERSTEIG    50
    KLLNSYLEKK TELEDHSVHL LFSANRWEQV PLIKAKLNQG VTLVLDRYAF 100
    SGVAFTGAKE NFSLDWCKQP DVGLPKPDLI LFLQLQLLDA AARGEFGLER 150
    YETGTFQKQV LLCFQQLMEE KNLNWKVVDA SKSIEEVHKE IRAHSEDAIR 200
    NAAQRPLGEL WK 212
    Length:212
    Mass (Da):23,915
    Last modified:July 1, 2008 - v2
    Checksum:i2F9BC1770DE5902B
    GO
    Isoform Short (identifier: P97930-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         81-212: Missing.

    Show »
    Length:80
    Mass (Da):8,947
    Checksum:iE4A9A7E19995D02D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti151 – 1511Y → N in BAC40343. (PubMed:16141072)Curated
    Sequence conflicti183 – 21230SIEEV…GELWK → RTPSETLHRGHWGSYGNKSA SIANTIFWFCKRLVEGSHLY TISRS in AAB46838. (PubMed:8845311)CuratedAdd
    BLAST

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei81 – 212132Missing in isoform Short. 1 PublicationVSP_003029Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S82852 mRNA. Translation: AAB46837.1.
    S82853 mRNA. Translation: AAB46838.1.
    AK088416 mRNA. Translation: BAC40343.1.
    BC030178 mRNA. Translation: AAH30178.1.
    CCDSiCCDS35672.1. [P97930-2]
    CCDS48329.1. [P97930-1]
    RefSeqiNP_001099137.1. NM_001105667.1. [P97930-1]
    UniGeneiMm.250332.

    Genome annotation databases

    EnsembliENSMUST00000027503; ENSMUSP00000027503; ENSMUSG00000026281. [P97930-1]
    ENSMUST00000112890; ENSMUSP00000108511; ENSMUSG00000026281. [P97930-2]
    GeneIDi21915.
    KEGGimmu:21915.
    UCSCiuc007cek.2. mouse. [P97930-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S82852 mRNA. Translation: AAB46837.1 .
    S82853 mRNA. Translation: AAB46838.1 .
    AK088416 mRNA. Translation: BAC40343.1 .
    BC030178 mRNA. Translation: AAH30178.1 .
    CCDSi CCDS35672.1. [P97930-2 ]
    CCDS48329.1. [P97930-1 ]
    RefSeqi NP_001099137.1. NM_001105667.1. [P97930-1 ]
    UniGenei Mm.250332.

    3D structure databases

    ProteinModelPortali P97930.
    SMRi P97930. Positions 4-212.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 204232. 1 interaction.

    PTM databases

    PhosphoSitei P97930.

    Proteomic databases

    MaxQBi P97930.
    PaxDbi P97930.
    PRIDEi P97930.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000027503 ; ENSMUSP00000027503 ; ENSMUSG00000026281 . [P97930-1 ]
    ENSMUST00000112890 ; ENSMUSP00000108511 ; ENSMUSG00000026281 . [P97930-2 ]
    GeneIDi 21915.
    KEGGi mmu:21915.
    UCSCi uc007cek.2. mouse. [P97930-1 ]

    Organism-specific databases

    CTDi 1841.
    MGIi MGI:108396. Dtymk.

    Phylogenomic databases

    eggNOGi COG0125.
    GeneTreei ENSGT00390000017546.
    HOGENOMi HOG000229079.
    HOVERGENi HBG051418.
    KOi K00943.
    OMAi GKMIDSY.
    OrthoDBi EOG7WQ7T8.
    TreeFami TF324638.

    Enzyme and pathway databases

    UniPathwayi UPA00575 .
    SABIO-RK P97930.

    Miscellaneous databases

    NextBioi 301468.
    PROi P97930.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P97930.
    Bgeei P97930.
    CleanExi MM_DTYMK.
    Genevestigatori P97930.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    HAMAPi MF_00165. Thymidylate_kinase.
    InterProi IPR027417. P-loop_NTPase.
    IPR018095. Thymidylate_kin_CS.
    IPR018094. Thymidylate_kinase.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00041. DTMP_kinase. 1 hit.
    PROSITEi PS01331. THYMIDYLATE_KINASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular characterization of the murine thymidylate kinase gene."
      Liang P., Averboukh L., Zhu W., Haley T., Pardee A.B.
      Cell Growth Differ. 6:1333-1338(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS LONG AND SHORT).
      Strain: BALB/c.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LONG).
      Strain: NOD.
      Tissue: Thymus.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LONG).
      Strain: Czech II.
      Tissue: Mammary tumor.

    Entry informationi

    Entry nameiKTHY_MOUSE
    AccessioniPrimary (citable) accession number: P97930
    Secondary accession number(s): Q8C2L0, Q8K2S2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: July 1, 2008
    Last modified: October 1, 2014
    This is version 111 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3