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P97930

- KTHY_MOUSE

UniProt

P97930 - KTHY_MOUSE

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Protein

Thymidylate kinase

Gene
Dtymk, Tmk
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes the conversion of dTMP to dTDP.UniRule annotation

Catalytic activityi

ATP + dTMP = ADP + dTDP.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi13 – 208ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. nucleoside phosphate kinase activity Source: Ensembl
  3. thymidylate kinase activity Source: MGI

GO - Biological processi

  1. cellular response to growth factor stimulus Source: MGI
  2. dTDP biosynthetic process Source: MGI
  3. dTTP biosynthetic process Source: UniProtKB-UniPathway
  4. myoblast differentiation Source: Ensembl
  5. nucleotide biosynthetic process Source: MGI
  6. nucleotide phosphorylation Source: GOC
  7. response to cadmium ion Source: Ensembl
  8. response to estrogen Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Nucleotide biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

SABIO-RKP97930.
UniPathwayiUPA00575.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidylate kinase (EC:2.7.4.9)
Alternative name(s):
dTMP kinase
Gene namesi
Name:Dtymk
Synonyms:Tmk
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:108396. Dtymk.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrial intermembrane space Source: Ensembl
  2. mitochondrial matrix Source: Ensembl
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 212211Thymidylate kinaseUniRule annotationPRO_0000155211Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine By similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP97930.
PaxDbiP97930.
PRIDEiP97930.

PTM databases

PhosphoSiteiP97930.

Expressioni

Gene expression databases

ArrayExpressiP97930.
BgeeiP97930.
CleanExiMM_DTYMK.
GenevestigatoriP97930.

Interactioni

Protein-protein interaction databases

BioGridi204232. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP97930.
SMRiP97930. Positions 4-212.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0125.
GeneTreeiENSGT00390000017546.
HOGENOMiHOG000229079.
HOVERGENiHBG051418.
KOiK00943.
OMAiGKMIDSY.
OrthoDBiEOG7WQ7T8.
TreeFamiTF324638.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00165. Thymidylate_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR018095. Thymidylate_kin_CS.
IPR018094. Thymidylate_kinase.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00041. DTMP_kinase. 1 hit.
PROSITEiPS01331. THYMIDYLATE_KINASE. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform Long (identifier: P97930-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MASRRGALIV LEGVDRAGKT TQGLKLVTAL CASGHRAELL RFPERSTEIG    50
KLLNSYLEKK TELEDHSVHL LFSANRWEQV PLIKAKLNQG VTLVLDRYAF 100
SGVAFTGAKE NFSLDWCKQP DVGLPKPDLI LFLQLQLLDA AARGEFGLER 150
YETGTFQKQV LLCFQQLMEE KNLNWKVVDA SKSIEEVHKE IRAHSEDAIR 200
NAAQRPLGEL WK 212
Length:212
Mass (Da):23,915
Last modified:July 1, 2008 - v2
Checksum:i2F9BC1770DE5902B
GO
Isoform Short (identifier: P97930-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     81-212: Missing.

Show »
Length:80
Mass (Da):8,947
Checksum:iE4A9A7E19995D02D
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei81 – 212132Missing in isoform Short. VSP_003029Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti151 – 1511Y → N in BAC40343. 1 Publication
Sequence conflicti183 – 21230SIEEV…GELWK → RTPSETLHRGHWGSYGNKSA SIANTIFWFCKRLVEGSHLY TISRS in AAB46838. 1 PublicationAdd
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S82852 mRNA. Translation: AAB46837.1.
S82853 mRNA. Translation: AAB46838.1.
AK088416 mRNA. Translation: BAC40343.1.
BC030178 mRNA. Translation: AAH30178.1.
CCDSiCCDS35672.1. [P97930-2]
CCDS48329.1. [P97930-1]
RefSeqiNP_001099137.1. NM_001105667.1. [P97930-1]
UniGeneiMm.250332.

Genome annotation databases

EnsembliENSMUST00000027503; ENSMUSP00000027503; ENSMUSG00000026281. [P97930-1]
ENSMUST00000112890; ENSMUSP00000108511; ENSMUSG00000026281. [P97930-2]
GeneIDi21915.
KEGGimmu:21915.
UCSCiuc007cek.2. mouse. [P97930-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S82852 mRNA. Translation: AAB46837.1 .
S82853 mRNA. Translation: AAB46838.1 .
AK088416 mRNA. Translation: BAC40343.1 .
BC030178 mRNA. Translation: AAH30178.1 .
CCDSi CCDS35672.1. [P97930-2 ]
CCDS48329.1. [P97930-1 ]
RefSeqi NP_001099137.1. NM_001105667.1. [P97930-1 ]
UniGenei Mm.250332.

3D structure databases

ProteinModelPortali P97930.
SMRi P97930. Positions 4-212.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 204232. 1 interaction.

PTM databases

PhosphoSitei P97930.

Proteomic databases

MaxQBi P97930.
PaxDbi P97930.
PRIDEi P97930.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000027503 ; ENSMUSP00000027503 ; ENSMUSG00000026281 . [P97930-1 ]
ENSMUST00000112890 ; ENSMUSP00000108511 ; ENSMUSG00000026281 . [P97930-2 ]
GeneIDi 21915.
KEGGi mmu:21915.
UCSCi uc007cek.2. mouse. [P97930-1 ]

Organism-specific databases

CTDi 1841.
MGIi MGI:108396. Dtymk.

Phylogenomic databases

eggNOGi COG0125.
GeneTreei ENSGT00390000017546.
HOGENOMi HOG000229079.
HOVERGENi HBG051418.
KOi K00943.
OMAi GKMIDSY.
OrthoDBi EOG7WQ7T8.
TreeFami TF324638.

Enzyme and pathway databases

UniPathwayi UPA00575 .
SABIO-RK P97930.

Miscellaneous databases

NextBioi 301468.
PROi P97930.
SOURCEi Search...

Gene expression databases

ArrayExpressi P97930.
Bgeei P97930.
CleanExi MM_DTYMK.
Genevestigatori P97930.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
HAMAPi MF_00165. Thymidylate_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR018095. Thymidylate_kin_CS.
IPR018094. Thymidylate_kinase.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00041. DTMP_kinase. 1 hit.
PROSITEi PS01331. THYMIDYLATE_KINASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular characterization of the murine thymidylate kinase gene."
    Liang P., Averboukh L., Zhu W., Haley T., Pardee A.B.
    Cell Growth Differ. 6:1333-1338(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS LONG AND SHORT).
    Strain: BALB/c.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LONG).
    Strain: NOD.
    Tissue: Thymus.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LONG).
    Strain: Czech II.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiKTHY_MOUSE
AccessioniPrimary (citable) accession number: P97930
Secondary accession number(s): Q8C2L0, Q8K2S2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 1, 2008
Last modified: July 9, 2014
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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