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P97930 (KTHY_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 106. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Thymidylate kinase

EC=2.7.4.9
Alternative name(s):
dTMP kinase
Gene names
Name:Dtymk
Synonyms:Tmk
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length212 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the conversion of dTMP to dTDP. HAMAP-Rule MF_00165

Catalytic activity

ATP + dTMP = ADP + dTDP. HAMAP-Rule MF_00165

Pathway

Pyrimidine metabolism; dTTP biosynthesis. HAMAP-Rule MF_00165

Sequence similarities

Belongs to the thymidylate kinase family.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform Long (identifier: P97930-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform Short (identifier: P97930-2)

The sequence of this isoform differs from the canonical sequence as follows:
     81-212: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 212211Thymidylate kinase HAMAP-Rule MF_00165
PRO_0000155211

Regions

Nucleotide binding13 – 208ATP By similarity

Amino acid modifications

Modified residue21N-acetylalanine By similarity

Natural variations

Alternative sequence81 – 212132Missing in isoform Short.
VSP_003029

Experimental info

Sequence conflict1511Y → N in BAC40343. Ref.2
Sequence conflict183 – 21230SIEEV…GELWK → RTPSETLHRGHWGSYGNKSA SIANTIFWFCKRLVEGSHLY TISRS in AAB46838. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform Long [UniParc].

Last modified July 1, 2008. Version 2.
Checksum: 2F9BC1770DE5902B

FASTA21223,915
        10         20         30         40         50         60 
MASRRGALIV LEGVDRAGKT TQGLKLVTAL CASGHRAELL RFPERSTEIG KLLNSYLEKK 

        70         80         90        100        110        120 
TELEDHSVHL LFSANRWEQV PLIKAKLNQG VTLVLDRYAF SGVAFTGAKE NFSLDWCKQP 

       130        140        150        160        170        180 
DVGLPKPDLI LFLQLQLLDA AARGEFGLER YETGTFQKQV LLCFQQLMEE KNLNWKVVDA 

       190        200        210 
SKSIEEVHKE IRAHSEDAIR NAAQRPLGEL WK 

« Hide

Isoform Short [UniParc].

Checksum: E4A9A7E19995D02D
Show »

FASTA808,947

References

« Hide 'large scale' references
[1]"Molecular characterization of the murine thymidylate kinase gene."
Liang P., Averboukh L., Zhu W., Haley T., Pardee A.B.
Cell Growth Differ. 6:1333-1338(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS LONG AND SHORT).
Strain: BALB/c.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LONG).
Strain: NOD.
Tissue: Thymus.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LONG).
Strain: Czech II.
Tissue: Mammary tumor.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
S82852 mRNA. Translation: AAB46837.1.
S82853 mRNA. Translation: AAB46838.1.
AK088416 mRNA. Translation: BAC40343.1.
BC030178 mRNA. Translation: AAH30178.1.
RefSeqNP_001099137.1. NM_001105667.1.
UniGeneMm.250332.

3D structure databases

ProteinModelPortalP97930.
SMRP97930. Positions 4-212.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteP97930.

Proteomic databases

PaxDbP97930.
PRIDEP97930.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000027503; ENSMUSP00000027503; ENSMUSG00000026281. [P97930-1]
ENSMUST00000112890; ENSMUSP00000108511; ENSMUSG00000026281. [P97930-2]
GeneID21915.
KEGGmmu:21915.
UCSCuc007cek.2. mouse. [P97930-1]

Organism-specific databases

CTD1841.
MGIMGI:108396. Dtymk.

Phylogenomic databases

eggNOGCOG0125.
GeneTreeENSGT00390000017546.
HOGENOMHOG000229079.
HOVERGENHBG051418.
KOK00943.
OMAGKMIDSY.
OrthoDBEOG7WQ7T8.
TreeFamTF324638.

Enzyme and pathway databases

SABIO-RKP97930.
UniPathwayUPA00575.

Gene expression databases

ArrayExpressP97930.
BgeeP97930.
CleanExMM_DTYMK.
GenevestigatorP97930.

Family and domain databases

HAMAPMF_00165. Thymidylate_kinase.
InterProIPR027417. P-loop_NTPase.
IPR018095. Thymidylate_kin_CS.
IPR018094. Thymidylate_kinase.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00041. DTMP_kinase. 1 hit.
PROSITEPS01331. THYMIDYLATE_KINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio301468.
PROP97930.
SOURCESearch...

Entry information

Entry nameKTHY_MOUSE
AccessionPrimary (citable) accession number: P97930
Secondary accession number(s): Q8C2L0, Q8K2S2
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 1, 2008
Last modified: March 19, 2014
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot