Reviewed, UniProtKB/Swiss-Prot P97926 (OXYR_MOUSE)

Names and origin

Protein names

Recommended name:
    Oxytocin receptor
      Short name=OT-R

Gene names

Name:

Oxtr

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	388 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Gene Ontology (GO)
Biological process	G-protein coupled receptor protein signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW positive regulation of blood pressure Inferred from genetic interaction. Source: MGI
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	oxytocin receptor activity Inferred from electronic annotation. Source: InterPro vasopressin receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 388	388	Oxytocin receptor		PRO_0000070000
Regions
	Topological domain	1 – 38	38	Extracellular Potential
	Transmembrane	39 – 63	25	1 Potential
	Topological domain	64 – 74	11	Cytoplasmic Potential
	Transmembrane	75 – 97	23	2 Potential
	Topological domain	98 – 113	16	Extracellular Potential
	Transmembrane	114 – 135	22	3 Potential
	Topological domain	136 – 154	19	Cytoplasmic Potential
	Transmembrane	155 – 175	21	4 Potential
	Topological domain	176 – 202	27	Extracellular Potential
	Transmembrane	203 – 225	23	5 Potential
	Topological domain	226 – 274	49	Cytoplasmic Potential
	Transmembrane	275 – 293	19	6 Potential
	Topological domain	294 – 308	15	Extracellular Potential
	Transmembrane	309 – 331	23	7 Potential
	Topological domain	332 – 388	57	Cytoplasmic Potential
	Compositional bias	129 – 132	4	Poly-Leu
	Compositional bias	236 – 242	7	Poly-Ala
Amino acid modifications
	Glycosylation	8	1	N-linked (GlcNAc...) Potential
	Glycosylation	26	1	N-linked (GlcNAc...) Potential
	Disulfide bond	112 ↔ 187		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P97926-1 [UniParc]. Last modified May 1, 1997. Version 1. Checksum: 77FF8829ACBE5285	FASTA	388	42,752
	10 20 30 40 50 60 MEGTPAANWS IELDLGSGVP PGAEGNLTAG PPRRNEALAR VEVAVLCLIL FLALSGNACV 70 80 90 100 110 120 LLALRTTRHK HSRLFFFMKH LSIADLVVAV FQVLPQLLWD ITFRFYGPDL LCRLVKYLQV 130 140 150 160 170 180 VGMFASTYLL LLMSLDRCLA ICQPLRSLRR RTDRLAVLAT WLGCLVASVP QVHIFSLREV 190 200 210 220 230 240 ADGVFDCWAV FIQPWGPKAY VTWITLAVYI VPVIVLAACY GLISFKIWQN LRLKTAAAAA 250 260 270 280 290 300 AAEGSDAAGG AGRAALARVS SVKLISKAKI RTVKMTFIIV LAFIVCWTPF FFVQMWSVWD 310 320 330 340 350 360 VNAPKEASAF IIAMLLASLN SCCNPWIYML FTGHLFHELV QRFLCCSARY LKGSRPGETS 370 380 ISKKSNSSTF VLSRCSSSQR SCSQPSSA

References

[1]	"Structure and expression of the mouse oxytocin receptor gene." Kubota Y., Kimura T., Hashimoto K., Tokugawa Y., Nobunaga K., Azuma C., Saji F., Murata Y. Mol. Cell. Endocrinol. 124:25-32(1996) [PubMed: 9027321] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]. Strain: 129/Sv.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	D86599 mRNA. Translation: BAA18995.1. D86631 Genomic DNA. Translation: BAA18996.1.
IPI	IPI00130968.
UniGene	Mm.333310
3D structure databases
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
Genome annotation databases
Ensembl	ENSMUSG00000049112. Mus musculus. [Contig view]
Organism-specific databases
MGI	MGI:109147. Oxtr.
Phylogenomic databases
HOGENOM	P97926.
HOVERGEN	P97926.
Gene expression databases
ArrayExpress	P97926.
Bgee	P97926.
CleanEx	MM_OXTR.
Family and domain databases
InterPro	IPR000276. 7TM_GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_supfam. IPR002062. Oxytocn_rcpt. IPR001817. Vasoprsn_rcpt. [Graphical view]
PANTHER	PTHR19264:SF46. Oxytocn_rcpt. 1 hit.
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR00665. OXYTOCINR. PR00896. VASOPRESSINR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
SOURCE	Search...

Entry information

Entry name

OXYR_MOUSE

Accession

Primary (citable) accession number: P97926

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	May 1, 1997
Last modified:	June 16, 2009
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)