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Protein

Oxytocin receptor

Gene

Oxtr

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_310308. Vasopressin-like receptors.
REACT_347934. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Oxytocin receptor
Short name:
OT-R
Gene namesi
Name:Oxtr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:109147. Oxtr.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3838ExtracellularSequence AnalysisAdd
BLAST
Transmembranei39 – 6325Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini64 – 7411CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei75 – 9723Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini98 – 11316ExtracellularSequence AnalysisAdd
BLAST
Transmembranei114 – 13522Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini136 – 15419CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei155 – 17521Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini176 – 20227ExtracellularSequence AnalysisAdd
BLAST
Transmembranei203 – 22523Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini226 – 27449CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei275 – 29319Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini294 – 30815ExtracellularSequence AnalysisAdd
BLAST
Transmembranei309 – 33123Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini332 – 38857CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 388388Oxytocin receptorPRO_0000070000Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi8 – 81N-linked (GlcNAc...)Sequence Analysis
Glycosylationi26 – 261N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi112 ↔ 187PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP97926.

PTM databases

PhosphoSiteiP97926.

Expressioni

Gene expression databases

CleanExiMM_OXTR.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000051132.

Structurei

3D structure databases

ProteinModelPortaliP97926.
SMRiP97926. Positions 1-367.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi129 – 1324Poly-Leu
Compositional biasi236 – 2427Poly-Ala

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG299951.
GeneTreeiENSGT00760000119156.
HOGENOMiHOG000237331.
HOVERGENiHBG105710.
InParanoidiP97926.
KOiK04229.
OMAiGPPRRNE.
OrthoDBiEOG7Z69CP.
TreeFamiTF106499.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002062. Oxytocn_rcpt.
IPR001817. Vasoprsn_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00665. OXYTOCINR.
PR00896. VASOPRESSINR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P97926-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGTPAANWS IELDLGSGVP PGAEGNLTAG PPRRNEALAR VEVAVLCLIL
60 70 80 90 100
FLALSGNACV LLALRTTRHK HSRLFFFMKH LSIADLVVAV FQVLPQLLWD
110 120 130 140 150
ITFRFYGPDL LCRLVKYLQV VGMFASTYLL LLMSLDRCLA ICQPLRSLRR
160 170 180 190 200
RTDRLAVLAT WLGCLVASVP QVHIFSLREV ADGVFDCWAV FIQPWGPKAY
210 220 230 240 250
VTWITLAVYI VPVIVLAACY GLISFKIWQN LRLKTAAAAA AAEGSDAAGG
260 270 280 290 300
AGRAALARVS SVKLISKAKI RTVKMTFIIV LAFIVCWTPF FFVQMWSVWD
310 320 330 340 350
VNAPKEASAF IIAMLLASLN SCCNPWIYML FTGHLFHELV QRFLCCSARY
360 370 380
LKGSRPGETS ISKKSNSSTF VLSRRSSSQR SCSQPSSA
Length:388
Mass (Da):42,805
Last modified:October 16, 2013 - v2
Checksum:i77FF8829ACAB4785
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti375 – 3751R → C in BAA18995 (PubMed:9027321).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86599 mRNA. Translation: BAA18995.1.
D86631 Genomic DNA. Translation: BAA18996.1.
AC153594 Genomic DNA. No translation available.
CCDSiCCDS39588.1.
RefSeqiNP_001074616.1. NM_001081147.1.
XP_006505786.1. XM_006505723.1.
UniGeneiMm.333310.

Genome annotation databases

EnsembliENSMUST00000053306; ENSMUSP00000051132; ENSMUSG00000049112.
GeneIDi18430.
KEGGimmu:18430.
UCSCiuc009deb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86599 mRNA. Translation: BAA18995.1.
D86631 Genomic DNA. Translation: BAA18996.1.
AC153594 Genomic DNA. No translation available.
CCDSiCCDS39588.1.
RefSeqiNP_001074616.1. NM_001081147.1.
XP_006505786.1. XM_006505723.1.
UniGeneiMm.333310.

3D structure databases

ProteinModelPortaliP97926.
SMRiP97926. Positions 1-367.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000051132.

Chemistry

ChEMBLiCHEMBL3243907.
GuidetoPHARMACOLOGYi369.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiP97926.

Proteomic databases

PRIDEiP97926.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000053306; ENSMUSP00000051132; ENSMUSG00000049112.
GeneIDi18430.
KEGGimmu:18430.
UCSCiuc009deb.1. mouse.

Organism-specific databases

CTDi5021.
MGIiMGI:109147. Oxtr.

Phylogenomic databases

eggNOGiNOG299951.
GeneTreeiENSGT00760000119156.
HOGENOMiHOG000237331.
HOVERGENiHBG105710.
InParanoidiP97926.
KOiK04229.
OMAiGPPRRNE.
OrthoDBiEOG7Z69CP.
TreeFamiTF106499.

Enzyme and pathway databases

ReactomeiREACT_310308. Vasopressin-like receptors.
REACT_347934. G alpha (q) signalling events.

Miscellaneous databases

NextBioi294094.
PROiP97926.
SOURCEiSearch...

Gene expression databases

CleanExiMM_OXTR.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002062. Oxytocn_rcpt.
IPR001817. Vasoprsn_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00665. OXYTOCINR.
PR00896. VASOPRESSINR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Strain: 129/Sv.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.

Entry informationi

Entry nameiOXYR_MOUSE
AccessioniPrimary (citable) accession number: P97926
Secondary accession number(s): F8VQ78
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: October 16, 2013
Last modified: July 22, 2015
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.