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Protein

Oxytocin receptor

Gene

Oxtr

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-388479. Vasopressin-like receptors.
R-MMU-416476. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Oxytocin receptor
Short name:
OT-R
Gene namesi
Name:Oxtr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:109147. Oxtr.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 38ExtracellularSequence analysisAdd BLAST38
Transmembranei39 – 63Helical; Name=1Sequence analysisAdd BLAST25
Topological domaini64 – 74CytoplasmicSequence analysisAdd BLAST11
Transmembranei75 – 97Helical; Name=2Sequence analysisAdd BLAST23
Topological domaini98 – 113ExtracellularSequence analysisAdd BLAST16
Transmembranei114 – 135Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini136 – 154CytoplasmicSequence analysisAdd BLAST19
Transmembranei155 – 175Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini176 – 202ExtracellularSequence analysisAdd BLAST27
Transmembranei203 – 225Helical; Name=5Sequence analysisAdd BLAST23
Topological domaini226 – 274CytoplasmicSequence analysisAdd BLAST49
Transmembranei275 – 293Helical; Name=6Sequence analysisAdd BLAST19
Topological domaini294 – 308ExtracellularSequence analysisAdd BLAST15
Transmembranei309 – 331Helical; Name=7Sequence analysisAdd BLAST23
Topological domaini332 – 388CytoplasmicSequence analysisAdd BLAST57

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3243907.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000700001 – 388Oxytocin receptorAdd BLAST388

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi8N-linked (GlcNAc...)Sequence analysis1
Glycosylationi26N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi112 ↔ 187PROSITE-ProRule annotation
Modified residuei365PhosphoserineBy similarity1
Modified residuei367PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP97926.
PRIDEiP97926.

PTM databases

PhosphoSitePlusiP97926.

Expressioni

Gene expression databases

BgeeiENSMUSG00000049112.
CleanExiMM_OXTR.
ExpressionAtlasiP97926. baseline and differential.
GenevisibleiP97926. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000051132.

Structurei

3D structure databases

ProteinModelPortaliP97926.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi129 – 132Poly-Leu4
Compositional biasi236 – 242Poly-Ala7

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119156.
HOGENOMiHOG000237331.
HOVERGENiHBG105710.
InParanoidiP97926.
KOiK04229.
OMAiCCSASYL.
OrthoDBiEOG091G0DB6.
TreeFamiTF106499.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002062. Oxytocn_rcpt.
IPR001817. Vasoprsn_rcpt.
[Graphical view]
PANTHERiPTHR24241:SF19. PTHR24241:SF19. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00665. OXYTOCINR.
PR00896. VASOPRESSINR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P97926-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGTPAANWS IELDLGSGVP PGAEGNLTAG PPRRNEALAR VEVAVLCLIL
60 70 80 90 100
FLALSGNACV LLALRTTRHK HSRLFFFMKH LSIADLVVAV FQVLPQLLWD
110 120 130 140 150
ITFRFYGPDL LCRLVKYLQV VGMFASTYLL LLMSLDRCLA ICQPLRSLRR
160 170 180 190 200
RTDRLAVLAT WLGCLVASVP QVHIFSLREV ADGVFDCWAV FIQPWGPKAY
210 220 230 240 250
VTWITLAVYI VPVIVLAACY GLISFKIWQN LRLKTAAAAA AAEGSDAAGG
260 270 280 290 300
AGRAALARVS SVKLISKAKI RTVKMTFIIV LAFIVCWTPF FFVQMWSVWD
310 320 330 340 350
VNAPKEASAF IIAMLLASLN SCCNPWIYML FTGHLFHELV QRFLCCSARY
360 370 380
LKGSRPGETS ISKKSNSSTF VLSRRSSSQR SCSQPSSA
Length:388
Mass (Da):42,805
Last modified:October 16, 2013 - v2
Checksum:i77FF8829ACAB4785
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti375R → C in BAA18995 (PubMed:9027321).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86599 mRNA. Translation: BAA18995.1.
D86631 Genomic DNA. Translation: BAA18996.1.
AC153594 Genomic DNA. No translation available.
CCDSiCCDS39588.1.
RefSeqiNP_001074616.1. NM_001081147.1.
XP_006505786.1. XM_006505723.1.
UniGeneiMm.333310.

Genome annotation databases

EnsembliENSMUST00000053306; ENSMUSP00000051132; ENSMUSG00000049112.
GeneIDi18430.
KEGGimmu:18430.
UCSCiuc009deb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86599 mRNA. Translation: BAA18995.1.
D86631 Genomic DNA. Translation: BAA18996.1.
AC153594 Genomic DNA. No translation available.
CCDSiCCDS39588.1.
RefSeqiNP_001074616.1. NM_001081147.1.
XP_006505786.1. XM_006505723.1.
UniGeneiMm.333310.

3D structure databases

ProteinModelPortaliP97926.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000051132.

Chemistry databases

ChEMBLiCHEMBL3243907.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiP97926.

Proteomic databases

PaxDbiP97926.
PRIDEiP97926.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000053306; ENSMUSP00000051132; ENSMUSG00000049112.
GeneIDi18430.
KEGGimmu:18430.
UCSCiuc009deb.1. mouse.

Organism-specific databases

CTDi5021.
MGIiMGI:109147. Oxtr.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119156.
HOGENOMiHOG000237331.
HOVERGENiHBG105710.
InParanoidiP97926.
KOiK04229.
OMAiCCSASYL.
OrthoDBiEOG091G0DB6.
TreeFamiTF106499.

Enzyme and pathway databases

ReactomeiR-MMU-388479. Vasopressin-like receptors.
R-MMU-416476. G alpha (q) signalling events.

Miscellaneous databases

PROiP97926.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000049112.
CleanExiMM_OXTR.
ExpressionAtlasiP97926. baseline and differential.
GenevisibleiP97926. MM.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002062. Oxytocn_rcpt.
IPR001817. Vasoprsn_rcpt.
[Graphical view]
PANTHERiPTHR24241:SF19. PTHR24241:SF19. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00665. OXYTOCINR.
PR00896. VASOPRESSINR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOXYR_MOUSE
AccessioniPrimary (citable) accession number: P97926
Secondary accession number(s): F8VQ78
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: October 16, 2013
Last modified: November 2, 2016
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.