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P97926 (OXYR_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Oxytocin receptor
Short name=OT-R
Gene names
Name:Oxtr
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length388 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 388388Oxytocin receptor
PRO_0000070000

Regions

Topological domain1 – 3838Extracellular Potential
Transmembrane39 – 6325Helical; Name=1; Potential
Topological domain64 – 7411Cytoplasmic Potential
Transmembrane75 – 9723Helical; Name=2; Potential
Topological domain98 – 11316Extracellular Potential
Transmembrane114 – 13522Helical; Name=3; Potential
Topological domain136 – 15419Cytoplasmic Potential
Transmembrane155 – 17521Helical; Name=4; Potential
Topological domain176 – 20227Extracellular Potential
Transmembrane203 – 22523Helical; Name=5; Potential
Topological domain226 – 27449Cytoplasmic Potential
Transmembrane275 – 29319Helical; Name=6; Potential
Topological domain294 – 30815Extracellular Potential
Transmembrane309 – 33123Helical; Name=7; Potential
Topological domain332 – 38857Cytoplasmic Potential
Compositional bias129 – 1324Poly-Leu
Compositional bias236 – 2427Poly-Ala

Amino acid modifications

Glycosylation81N-linked (GlcNAc...) Potential
Glycosylation261N-linked (GlcNAc...) Potential
Disulfide bond112 ↔ 187 By similarity

Sequences

Sequence LengthMass (Da)Tools
P97926 [UniParc].

Last modified May 1, 1997. Version 1.
Checksum: 77FF8829ACBE5285

FASTA38842,752
        10         20         30         40         50         60 
MEGTPAANWS IELDLGSGVP PGAEGNLTAG PPRRNEALAR VEVAVLCLIL FLALSGNACV 

        70         80         90        100        110        120 
LLALRTTRHK HSRLFFFMKH LSIADLVVAV FQVLPQLLWD ITFRFYGPDL LCRLVKYLQV 

       130        140        150        160        170        180 
VGMFASTYLL LLMSLDRCLA ICQPLRSLRR RTDRLAVLAT WLGCLVASVP QVHIFSLREV 

       190        200        210        220        230        240 
ADGVFDCWAV FIQPWGPKAY VTWITLAVYI VPVIVLAACY GLISFKIWQN LRLKTAAAAA 

       250        260        270        280        290        300 
AAEGSDAAGG AGRAALARVS SVKLISKAKI RTVKMTFIIV LAFIVCWTPF FFVQMWSVWD 

       310        320        330        340        350        360 
VNAPKEASAF IIAMLLASLN SCCNPWIYML FTGHLFHELV QRFLCCSARY LKGSRPGETS 

       370        380 
ISKKSNSSTF VLSRCSSSQR SCSQPSSA

« Hide

References

[1]"Structure and expression of the mouse oxytocin receptor gene."
Kubota Y., Kimura T., Hashimoto K., Tokugawa Y., Nobunaga K., Azuma C., Saji F., Murata Y.
Mol. Cell. Endocrinol. 124:25-32(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
Strain: 129/Sv.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		D86599 mRNA. Translation: BAA18995.1.
D86631 Genomic DNA. Translation: BAA18996.1.
IPIIPI00130968.
UniGeneMm.333310.

3D structure databases

ProteinModelPortalP97926.
SMRP97926. Positions 1-367.
ModBaseSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000051132.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteP97926.

Proteomic databases

PRIDEP97926.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

UCSCuc009deb.1. mouse.

Organism-specific databases

MGIMGI:109147. Oxtr.

Phylogenomic databases

eggNOGNOG299951.
HOGENOMHOG000237331.
HOVERGENHBG105710.
InParanoidP97926.
OrthoDBEOG4VHK6S.

Gene expression databases

CleanExMM_OXTR.
GenevestigatorP97926.

Family and domain databases

InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002062. Oxytocn_rcpt.
IPR001817. Vasoprsn_rcpt.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00665. OXYTOCINR.
PR00896. VASOPRESSINR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

SOURCESearch...

Entry information

Entry nameOXYR_MOUSE
AccessionPrimary (citable) accession number: P97926
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 1, 1997
Last modified: May 1, 2013
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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