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Reviewed, UniProtKB/Swiss-Prot P97926 (OXYR_MOUSE)

Last modified June 16, 2009. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Oxytocin receptor
      Short name=OT-R
Gene names
Name: Oxtr
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMus

Protein attributes

Sequence length388 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Function

Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 388388Oxytocin receptor
PRO_0000070000

Regions

Topological domain1 – 3838Extracellular Potential
Transmembrane39 – 63251 Potential
Topological domain64 – 7411Cytoplasmic Potential
Transmembrane75 – 97232 Potential
Topological domain98 – 11316Extracellular Potential
Transmembrane114 – 135223 Potential
Topological domain136 – 15419Cytoplasmic Potential
Transmembrane155 – 175214 Potential
Topological domain176 – 20227Extracellular Potential
Transmembrane203 – 225235 Potential
Topological domain226 – 27449Cytoplasmic Potential
Transmembrane275 – 293196 Potential
Topological domain294 – 30815Extracellular Potential
Transmembrane309 – 331237 Potential
Topological domain332 – 38857Cytoplasmic Potential
Compositional bias129 – 1324Poly-Leu
Compositional bias236 – 2427Poly-Ala

Amino acid modifications

Glycosylation81N-linked (GlcNAc...) Potential
Glycosylation261N-linked (GlcNAc...) Potential
Disulfide bond112 ↔ 187 By similarity

Sequences

Sequence LengthMass (Da)Tools
P97926-1 [UniParc].

Last modified May 1, 1997. Version 1.
Checksum: 77FF8829ACBE5285

FASTA38842,752
        10         20         30         40         50         60 
MEGTPAANWS IELDLGSGVP PGAEGNLTAG PPRRNEALAR VEVAVLCLIL FLALSGNACV 

        70         80         90        100        110        120 
LLALRTTRHK HSRLFFFMKH LSIADLVVAV FQVLPQLLWD ITFRFYGPDL LCRLVKYLQV 

       130        140        150        160        170        180 
VGMFASTYLL LLMSLDRCLA ICQPLRSLRR RTDRLAVLAT WLGCLVASVP QVHIFSLREV 

       190        200        210        220        230        240 
ADGVFDCWAV FIQPWGPKAY VTWITLAVYI VPVIVLAACY GLISFKIWQN LRLKTAAAAA 

       250        260        270        280        290        300 
AAEGSDAAGG AGRAALARVS SVKLISKAKI RTVKMTFIIV LAFIVCWTPF FFVQMWSVWD 

       310        320        330        340        350        360 
VNAPKEASAF IIAMLLASLN SCCNPWIYML FTGHLFHELV QRFLCCSARY LKGSRPGETS 

       370        380 
ISKKSNSSTF VLSRCSSSQR SCSQPSSA 

« Hide

References

[1]"Structure and expression of the mouse oxytocin receptor gene."
Kubota Y., Kimura T., Hashimoto K., Tokugawa Y., Nobunaga K., Azuma C., Saji F., Murata Y.
Mol. Cell. Endocrinol. 124:25-32(1996) [PubMed: 9027321] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
Strain: 129/Sv.
+Additional computationally mapped references.

Cross-references

Sequence databases

D86599 mRNA. Translation: BAA18995.1.
D86631 Genomic DNA. Translation: BAA18996.1.
IPIIPI00130968.
UniGeneMm.333310

3D structure databases

ModBaseSearch...

Protein family/group databases

GPCRDBSearch...

Genome annotation databases

EnsemblENSMUSG00000049112. Mus musculus. [Contig view]

Organism-specific databases

MGIMGI:109147. Oxtr.

Phylogenomic databases

HOGENOMP97926.
HOVERGENP97926.

Gene expression databases

ArrayExpressP97926.
BgeeP97926.
CleanExMM_OXTR.

Family and domain databases

InterProIPR000276. 7TM_GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_supfam.
IPR002062. Oxytocn_rcpt.
IPR001817. Vasoprsn_rcpt.
[Graphical view]
PANTHERPTHR19264:SF46. Oxytocn_rcpt. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00665. OXYTOCINR.
PR00896. VASOPRESSINR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

SOURCESearch...

Entry information

Entry nameOXYR_MOUSE
AccessionPrimary (citable) accession number: P97926
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 1, 1997
Last modified: June 16, 2009
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents