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P97926

- OXYR_MOUSE

UniProt

P97926 - OXYR_MOUSE

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Protein
Oxytocin receptor
Gene
Oxtr
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.

GO - Molecular functioni

  1. oxytocin receptor activity Source: InterPro
  2. vasopressin receptor activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. positive regulation of blood pressure Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_207651. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Oxytocin receptor
Short name:
OT-R
Gene namesi
Name:Oxtr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:109147. Oxtr.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3838Extracellular Reviewed prediction
Add
BLAST
Transmembranei39 – 6325Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini64 – 7411Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei75 – 9723Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini98 – 11316Extracellular Reviewed prediction
Add
BLAST
Transmembranei114 – 13522Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini136 – 15419Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei155 – 17521Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini176 – 20227Extracellular Reviewed prediction
Add
BLAST
Transmembranei203 – 22523Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini226 – 27449Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei275 – 29319Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini294 – 30815Extracellular Reviewed prediction
Add
BLAST
Transmembranei309 – 33123Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini332 – 38857Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 388388Oxytocin receptor
PRO_0000070000Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi8 – 81N-linked (GlcNAc...) Reviewed prediction
Glycosylationi26 – 261N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi112 ↔ 187 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP97926.

PTM databases

PhosphoSiteiP97926.

Expressioni

Gene expression databases

CleanExiMM_OXTR.
GenevestigatoriP97926.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000051132.

Structurei

3D structure databases

ProteinModelPortaliP97926.
SMRiP97926. Positions 1-367.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi129 – 1324Poly-Leu
Compositional biasi236 – 2427Poly-Ala

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG299951.
GeneTreeiENSGT00660000095384.
HOGENOMiHOG000237331.
HOVERGENiHBG105710.
InParanoidiP97926.
KOiK04229.
OMAiGPPRRNE.
OrthoDBiEOG7Z69CP.
TreeFamiTF106499.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002062. Oxytocn_rcpt.
IPR001817. Vasoprsn_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00665. OXYTOCINR.
PR00896. VASOPRESSINR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P97926-1 [UniParc]FASTAAdd to Basket

« Hide

MEGTPAANWS IELDLGSGVP PGAEGNLTAG PPRRNEALAR VEVAVLCLIL    50
FLALSGNACV LLALRTTRHK HSRLFFFMKH LSIADLVVAV FQVLPQLLWD 100
ITFRFYGPDL LCRLVKYLQV VGMFASTYLL LLMSLDRCLA ICQPLRSLRR 150
RTDRLAVLAT WLGCLVASVP QVHIFSLREV ADGVFDCWAV FIQPWGPKAY 200
VTWITLAVYI VPVIVLAACY GLISFKIWQN LRLKTAAAAA AAEGSDAAGG 250
AGRAALARVS SVKLISKAKI RTVKMTFIIV LAFIVCWTPF FFVQMWSVWD 300
VNAPKEASAF IIAMLLASLN SCCNPWIYML FTGHLFHELV QRFLCCSARY 350
LKGSRPGETS ISKKSNSSTF VLSRRSSSQR SCSQPSSA 388
Length:388
Mass (Da):42,805
Last modified:October 16, 2013 - v2
Checksum:i77FF8829ACAB4785
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti375 – 3751R → C in BAA18995. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D86599 mRNA. Translation: BAA18995.1.
D86631 Genomic DNA. Translation: BAA18996.1.
AC153594 Genomic DNA. No translation available.
CCDSiCCDS39588.1.
RefSeqiNP_001074616.1. NM_001081147.1.
XP_006505786.1. XM_006505723.1.
XP_006505787.1. XM_006505724.1.
UniGeneiMm.333310.

Genome annotation databases

EnsembliENSMUST00000053306; ENSMUSP00000051132; ENSMUSG00000049112.
GeneIDi18430.
KEGGimmu:18430.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D86599 mRNA. Translation: BAA18995.1 .
D86631 Genomic DNA. Translation: BAA18996.1 .
AC153594 Genomic DNA. No translation available.
CCDSi CCDS39588.1.
RefSeqi NP_001074616.1. NM_001081147.1.
XP_006505786.1. XM_006505723.1.
XP_006505787.1. XM_006505724.1.
UniGenei Mm.333310.

3D structure databases

ProteinModelPortali P97926.
SMRi P97926. Positions 1-367.
ModBasei Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000051132.

Chemistry

GuidetoPHARMACOLOGYi 369.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P97926.

Proteomic databases

PRIDEi P97926.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000053306 ; ENSMUSP00000051132 ; ENSMUSG00000049112 .
GeneIDi 18430.
KEGGi mmu:18430.

Organism-specific databases

CTDi 5021.
MGIi MGI:109147. Oxtr.

Phylogenomic databases

eggNOGi NOG299951.
GeneTreei ENSGT00660000095384.
HOGENOMi HOG000237331.
HOVERGENi HBG105710.
InParanoidi P97926.
KOi K04229.
OMAi GPPRRNE.
OrthoDBi EOG7Z69CP.
TreeFami TF106499.

Enzyme and pathway databases

Reactomei REACT_207651. G alpha (q) signalling events.

Miscellaneous databases

NextBioi 294094.
PROi P97926.
SOURCEi Search...

Gene expression databases

CleanExi MM_OXTR.
Genevestigatori P97926.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002062. Oxytocn_rcpt.
IPR001817. Vasoprsn_rcpt.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00665. OXYTOCINR.
PR00896. VASOPRESSINR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Strain: 129/Sv.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.

Entry informationi

Entry nameiOXYR_MOUSE
AccessioniPrimary (citable) accession number: P97926
Secondary accession number(s): F8VQ78
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: October 16, 2013
Last modified: September 3, 2014
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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