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P97926

- OXYR_MOUSE

UniProt

P97926 - OXYR_MOUSE

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Protein

Oxytocin receptor

Gene

Oxtr

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.

GO - Molecular functioni

  1. oxytocin receptor activity Source: Ensembl
  2. peptide hormone binding Source: Ensembl
  3. vasopressin receptor activity Source: InterPro

GO - Biological processi

  1. digestive tract development Source: Ensembl
  2. eating behavior Source: Ensembl
  3. ERK1 and ERK2 cascade Source: Ensembl
  4. estrous cycle phase Source: Ensembl
  5. female pregnancy Source: Ensembl
  6. heart development Source: Ensembl
  7. maternal behavior Source: Ensembl
  8. maternal process involved in parturition Source: Ensembl
  9. memory Source: Ensembl
  10. negative regulation of gastric acid secretion Source: Ensembl
  11. positive regulation of blood pressure Source: MGI
  12. positive regulation of cytosolic calcium ion concentration Source: Ensembl
  13. positive regulation of norepinephrine secretion Source: Ensembl
  14. positive regulation of penile erection Source: Ensembl
  15. positive regulation of synapse assembly Source: Ensembl
  16. positive regulation of synaptic transmission, GABAergic Source: Ensembl
  17. positive regulation of synaptic transmission, glutamatergic Source: Ensembl
  18. positive regulation of uterine smooth muscle contraction Source: Ensembl
  19. response to amphetamine Source: Ensembl
  20. response to anoxia Source: Ensembl
  21. response to cocaine Source: Ensembl
  22. response to cytokine Source: Ensembl
  23. response to drug Source: Ensembl
  24. response to estradiol Source: Ensembl
  25. response to peptide hormone Source: Ensembl
  26. response to progesterone Source: Ensembl
  27. sleep Source: Ensembl
  28. social behavior Source: Ensembl
  29. sperm ejaculation Source: Ensembl
  30. suckling behavior Source: Ensembl
  31. telencephalon development Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_207651. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Oxytocin receptor
Short name:
OT-R
Gene namesi
Name:Oxtr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:109147. Oxtr.

Subcellular locationi

GO - Cellular componenti

  1. apical plasma membrane Source: Ensembl
  2. cell-cell adherens junction Source: Ensembl
  3. integral component of membrane Source: UniProtKB-KW
  4. microvillus Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 388388Oxytocin receptorPRO_0000070000Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi8 – 81N-linked (GlcNAc...)Sequence Analysis
Glycosylationi26 – 261N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi112 ↔ 187PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP97926.

PTM databases

PhosphoSiteiP97926.

Expressioni

Gene expression databases

CleanExiMM_OXTR.
GenevestigatoriP97926.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000051132.

Structurei

3D structure databases

ProteinModelPortaliP97926.
SMRiP97926. Positions 1-367.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3838ExtracellularSequence AnalysisAdd
BLAST
Topological domaini64 – 7411CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini98 – 11316ExtracellularSequence AnalysisAdd
BLAST
Topological domaini136 – 15419CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini176 – 20227ExtracellularSequence AnalysisAdd
BLAST
Topological domaini226 – 27449CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini294 – 30815ExtracellularSequence AnalysisAdd
BLAST
Topological domaini332 – 38857CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei39 – 6325Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei75 – 9723Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei114 – 13522Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei155 – 17521Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei203 – 22523Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei275 – 29319Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei309 – 33123Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi129 – 1324Poly-Leu
Compositional biasi236 – 2427Poly-Ala

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG299951.
GeneTreeiENSGT00760000119156.
HOGENOMiHOG000237331.
HOVERGENiHBG105710.
InParanoidiP97926.
KOiK04229.
OMAiGPPRRNE.
OrthoDBiEOG7Z69CP.
TreeFamiTF106499.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002062. Oxytocn_rcpt.
IPR001817. Vasoprsn_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00665. OXYTOCINR.
PR00896. VASOPRESSINR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P97926-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEGTPAANWS IELDLGSGVP PGAEGNLTAG PPRRNEALAR VEVAVLCLIL
60 70 80 90 100
FLALSGNACV LLALRTTRHK HSRLFFFMKH LSIADLVVAV FQVLPQLLWD
110 120 130 140 150
ITFRFYGPDL LCRLVKYLQV VGMFASTYLL LLMSLDRCLA ICQPLRSLRR
160 170 180 190 200
RTDRLAVLAT WLGCLVASVP QVHIFSLREV ADGVFDCWAV FIQPWGPKAY
210 220 230 240 250
VTWITLAVYI VPVIVLAACY GLISFKIWQN LRLKTAAAAA AAEGSDAAGG
260 270 280 290 300
AGRAALARVS SVKLISKAKI RTVKMTFIIV LAFIVCWTPF FFVQMWSVWD
310 320 330 340 350
VNAPKEASAF IIAMLLASLN SCCNPWIYML FTGHLFHELV QRFLCCSARY
360 370 380
LKGSRPGETS ISKKSNSSTF VLSRRSSSQR SCSQPSSA
Length:388
Mass (Da):42,805
Last modified:October 16, 2013 - v2
Checksum:i77FF8829ACAB4785
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti375 – 3751R → C in BAA18995. (PubMed:9027321)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D86599 mRNA. Translation: BAA18995.1.
D86631 Genomic DNA. Translation: BAA18996.1.
AC153594 Genomic DNA. No translation available.
CCDSiCCDS39588.1.
RefSeqiNP_001074616.1. NM_001081147.1.
XP_006505786.1. XM_006505723.1.
XP_006505787.1. XM_006505724.1.
UniGeneiMm.333310.

Genome annotation databases

EnsembliENSMUST00000053306; ENSMUSP00000051132; ENSMUSG00000049112.
GeneIDi18430.
KEGGimmu:18430.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D86599 mRNA. Translation: BAA18995.1 .
D86631 Genomic DNA. Translation: BAA18996.1 .
AC153594 Genomic DNA. No translation available.
CCDSi CCDS39588.1.
RefSeqi NP_001074616.1. NM_001081147.1.
XP_006505786.1. XM_006505723.1.
XP_006505787.1. XM_006505724.1.
UniGenei Mm.333310.

3D structure databases

ProteinModelPortali P97926.
SMRi P97926. Positions 1-367.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000051132.

Chemistry

GuidetoPHARMACOLOGYi 369.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P97926.

Proteomic databases

PRIDEi P97926.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000053306 ; ENSMUSP00000051132 ; ENSMUSG00000049112 .
GeneIDi 18430.
KEGGi mmu:18430.

Organism-specific databases

CTDi 5021.
MGIi MGI:109147. Oxtr.

Phylogenomic databases

eggNOGi NOG299951.
GeneTreei ENSGT00760000119156.
HOGENOMi HOG000237331.
HOVERGENi HBG105710.
InParanoidi P97926.
KOi K04229.
OMAi GPPRRNE.
OrthoDBi EOG7Z69CP.
TreeFami TF106499.

Enzyme and pathway databases

Reactomei REACT_207651. G alpha (q) signalling events.

Miscellaneous databases

NextBioi 294094.
PROi P97926.
SOURCEi Search...

Gene expression databases

CleanExi MM_OXTR.
Genevestigatori P97926.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002062. Oxytocn_rcpt.
IPR001817. Vasoprsn_rcpt.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00665. OXYTOCINR.
PR00896. VASOPRESSINR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Strain: 129/Sv.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.

Entry informationi

Entry nameiOXYR_MOUSE
AccessioniPrimary (citable) accession number: P97926
Secondary accession number(s): F8VQ78
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: October 16, 2013
Last modified: October 29, 2014
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3