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P97926

- OXYR_MOUSE

UniProt

P97926 - OXYR_MOUSE

Protein

Oxytocin receptor

Gene

Oxtr

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 2 (16 Oct 2013)
      Previous versions | rss
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    Functioni

    Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.

    GO - Molecular functioni

    1. oxytocin receptor activity Source: InterPro
    2. vasopressin receptor activity Source: InterPro

    GO - Biological processi

    1. positive regulation of blood pressure Source: MGI

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_207651. G alpha (q) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Oxytocin receptor
    Short name:
    OT-R
    Gene namesi
    Name:Oxtr
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:109147. Oxtr.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 388388Oxytocin receptorPRO_0000070000Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi8 – 81N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi26 – 261N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi112 ↔ 187PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiP97926.

    PTM databases

    PhosphoSiteiP97926.

    Expressioni

    Gene expression databases

    CleanExiMM_OXTR.
    GenevestigatoriP97926.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000051132.

    Structurei

    3D structure databases

    ProteinModelPortaliP97926.
    SMRiP97926. Positions 1-367.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3838ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini64 – 7411CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini98 – 11316ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini136 – 15419CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini176 – 20227ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini226 – 27449CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini294 – 30815ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini332 – 38857CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei39 – 6325Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei75 – 9723Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei114 – 13522Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei155 – 17521Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei203 – 22523Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei275 – 29319Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei309 – 33123Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi129 – 1324Poly-Leu
    Compositional biasi236 – 2427Poly-Ala

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG299951.
    GeneTreeiENSGT00660000095384.
    HOGENOMiHOG000237331.
    HOVERGENiHBG105710.
    InParanoidiP97926.
    KOiK04229.
    OMAiGPPRRNE.
    OrthoDBiEOG7Z69CP.
    TreeFamiTF106499.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR002062. Oxytocn_rcpt.
    IPR001817. Vasoprsn_rcpt.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00665. OXYTOCINR.
    PR00896. VASOPRESSINR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P97926-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEGTPAANWS IELDLGSGVP PGAEGNLTAG PPRRNEALAR VEVAVLCLIL    50
    FLALSGNACV LLALRTTRHK HSRLFFFMKH LSIADLVVAV FQVLPQLLWD 100
    ITFRFYGPDL LCRLVKYLQV VGMFASTYLL LLMSLDRCLA ICQPLRSLRR 150
    RTDRLAVLAT WLGCLVASVP QVHIFSLREV ADGVFDCWAV FIQPWGPKAY 200
    VTWITLAVYI VPVIVLAACY GLISFKIWQN LRLKTAAAAA AAEGSDAAGG 250
    AGRAALARVS SVKLISKAKI RTVKMTFIIV LAFIVCWTPF FFVQMWSVWD 300
    VNAPKEASAF IIAMLLASLN SCCNPWIYML FTGHLFHELV QRFLCCSARY 350
    LKGSRPGETS ISKKSNSSTF VLSRRSSSQR SCSQPSSA 388
    Length:388
    Mass (Da):42,805
    Last modified:October 16, 2013 - v2
    Checksum:i77FF8829ACAB4785
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti375 – 3751R → C in BAA18995. (PubMed:9027321)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D86599 mRNA. Translation: BAA18995.1.
    D86631 Genomic DNA. Translation: BAA18996.1.
    AC153594 Genomic DNA. No translation available.
    CCDSiCCDS39588.1.
    RefSeqiNP_001074616.1. NM_001081147.1.
    XP_006505786.1. XM_006505723.1.
    XP_006505787.1. XM_006505724.1.
    UniGeneiMm.333310.

    Genome annotation databases

    EnsembliENSMUST00000053306; ENSMUSP00000051132; ENSMUSG00000049112.
    GeneIDi18430.
    KEGGimmu:18430.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D86599 mRNA. Translation: BAA18995.1 .
    D86631 Genomic DNA. Translation: BAA18996.1 .
    AC153594 Genomic DNA. No translation available.
    CCDSi CCDS39588.1.
    RefSeqi NP_001074616.1. NM_001081147.1.
    XP_006505786.1. XM_006505723.1.
    XP_006505787.1. XM_006505724.1.
    UniGenei Mm.333310.

    3D structure databases

    ProteinModelPortali P97926.
    SMRi P97926. Positions 1-367.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000051132.

    Chemistry

    GuidetoPHARMACOLOGYi 369.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P97926.

    Proteomic databases

    PRIDEi P97926.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000053306 ; ENSMUSP00000051132 ; ENSMUSG00000049112 .
    GeneIDi 18430.
    KEGGi mmu:18430.

    Organism-specific databases

    CTDi 5021.
    MGIi MGI:109147. Oxtr.

    Phylogenomic databases

    eggNOGi NOG299951.
    GeneTreei ENSGT00660000095384.
    HOGENOMi HOG000237331.
    HOVERGENi HBG105710.
    InParanoidi P97926.
    KOi K04229.
    OMAi GPPRRNE.
    OrthoDBi EOG7Z69CP.
    TreeFami TF106499.

    Enzyme and pathway databases

    Reactomei REACT_207651. G alpha (q) signalling events.

    Miscellaneous databases

    NextBioi 294094.
    PROi P97926.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_OXTR.
    Genevestigatori P97926.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR002062. Oxytocn_rcpt.
    IPR001817. Vasoprsn_rcpt.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00665. OXYTOCINR.
    PR00896. VASOPRESSINR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
      Strain: 129/Sv.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.

    Entry informationi

    Entry nameiOXYR_MOUSE
    AccessioniPrimary (citable) accession number: P97926
    Secondary accession number(s): F8VQ78
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: October 16, 2013
    Last modified: October 1, 2014
    This is version 99 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3