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Protein

Kalirin

Gene

Kalrn

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity. Isoforms 1 and 7 are necessary for neuronal development and axonal outgrowth. Isoform 6 is required for dendritic spine formation.3 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei2686 – 26861ATPPROSITE-ProRule annotation
Active sitei2776 – 27761Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi2663 – 26719ATPPROSITE-ProRule annotation

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • enzyme binding Source: RGD
  • guanyl-nucleotide exchange factor activity Source: HGNC
  • metal ion binding Source: UniProtKB-KW
  • protein serine/threonine kinase activity Source: UniProtKB-KW
  • Rho guanyl-nucleotide exchange factor activity Source: InterPro

GO - Biological processi

  • axonogenesis Source: RGD
  • intracellular signal transduction Source: HGNC
  • nervous system development Source: HGNC
  • regulation of dendrite development Source: RGD
  • regulation of Rho protein signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor, Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-RNO-193648. NRAGE signals death through JNK.
R-RNO-194840. Rho GTPase cycle.
R-RNO-3928662. EPHB-mediated forward signaling.
R-RNO-416476. G alpha (q) signalling events.
R-RNO-416482. G alpha (12/13) signalling events.
R-RNO-5687128. MAPK6/MAPK4 signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Kalirin (EC:2.7.11.1)
Alternative name(s):
Huntingtin-associated protein-interacting protein
PAM COOH-terminal interactor protein 10
Short name:
P-CIP10
Protein Duo
Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain
Gene namesi
Name:Kalrn
Synonyms:Duo, Hapip
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 11

Organism-specific databases

RGDi621865. Kalrn.

Subcellular locationi

  • Cytoplasm
  • Cytoplasmcytoskeleton

  • Note: Isoform 6 is largely associated with synaptosomal membranes and to punctate structures in cortical neurons. Isoforms 1 and 7 are expressed in neuronal cell bodies, isoform 7 is also found in neuronal processes.

GO - Cellular componenti

  • cytoskeleton Source: UniProtKB-SubCell
  • neuronal cell body Source: RGD
  • neuron projection Source: RGD
  • perinuclear region of cytoplasm Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL2176786.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 29592959KalirinPRO_0000080956Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1723 – 17231PhosphoserineBy similarity
Modified residuei1726 – 17261PhosphoserineBy similarity
Modified residuei1772 – 17721PhosphoserineCombined sources
Modified residuei1785 – 17851PhosphothreonineCombined sources
Modified residuei1790 – 17901PhosphoserineCombined sources
Modified residuei1885 – 18851PhosphothreonineBy similarity
Modified residuei2234 – 22341PhosphoserineBy similarity
Disulfide bondi2465 ↔ 2521PROSITE-ProRule annotation

Post-translational modificationi

Autophosphorylated.By similarity

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiP97924.
PRIDEiP97924.

PTM databases

iPTMnetiP97924.
PhosphoSiteiP97924.

Expressioni

Tissue specificityi

Highly expressed in the brain and nervous system. Isoform 6 is highly enriched in the postsynaptic density fraction of the cerebral cortex.2 Publications

Developmental stagei

Isoforms 1 and 7 are prevelant 2 dpp, isoform 6 is not detectable until 2 weeks after birth.1 Publication

Gene expression databases

ExpressionAtlasiP97924. baseline and differential.

Interactioni

Subunit structurei

Interacts with the C-terminal of peptidylglycine alpha-amidating monooxygenase (PAM) and with the huntingtin-associated protein 1 (HAP1). Interacts with FASLG (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Hap1P542563EBI-1397166,EBI-994539

GO - Molecular functioni

  • enzyme binding Source: RGD

Protein-protein interaction databases

IntActiP97924. 3 interactions.
MINTiMINT-159104.
STRINGi10116.ENSRNOP00000039072.

Structurei

Secondary structure

1
2959
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni1255 – 12584Combined sources
Helixi1259 – 127719Combined sources
Helixi1280 – 12856Combined sources
Turni1293 – 12975Combined sources
Helixi1299 – 13024Combined sources
Turni1304 – 13063Combined sources
Helixi1307 – 13159Combined sources
Helixi1317 – 13215Combined sources
Helixi1322 – 13243Combined sources
Helixi1328 – 13303Combined sources
Helixi1332 – 13376Combined sources
Helixi1340 – 13434Combined sources
Helixi1344 – 13507Combined sources
Helixi1352 – 13609Combined sources
Turni1361 – 13655Combined sources
Helixi1366 – 13749Combined sources
Helixi1380 – 140425Combined sources
Helixi1412 – 142817Combined sources
Beta strandi1622 – 16254Combined sources
Beta strandi1645 – 16506Combined sources
Beta strandi1658 – 166811Combined sources
Beta strandi1670 – 16756Combined sources
Helixi1676 – 16783Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1U3ONMR-A1617-1686[»]
2KR9NMR-A1253-1432[»]
ProteinModelPortaliP97924.
SMRiP97924. Positions 1252-1555, 1618-1684, 1891-2220, 2297-2361.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP97924.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini17 – 162146CRAL-TRIOPROSITE-ProRule annotationAdd
BLAST
Repeati149 – 290142Spectrin 1Sequence analysisAdd
BLAST
Repeati292 – 399108Spectrin 2Sequence analysisAdd
BLAST
Repeati400 – 517118Spectrin 3Sequence analysisAdd
BLAST
Repeati518 – 621104Spectrin 4Sequence analysisAdd
BLAST
Repeati622 – 752131Spectrin 5Sequence analysisAdd
BLAST
Repeati753 – 870118Spectrin 6Sequence analysisAdd
BLAST
Repeati871 – 977107Spectrin 7Sequence analysisAdd
BLAST
Repeati978 – 1101124Spectrin 8Sequence analysisAdd
BLAST
Repeati1102 – 1207106Spectrin 9Sequence analysisAdd
BLAST
Domaini1254 – 1429176DH 1PROSITE-ProRule annotationAdd
BLAST
Domaini1441 – 1553113PH 1PROSITE-ProRule annotationAdd
BLAST
Domaini1619 – 168466SH3 1PROSITE-ProRule annotationAdd
BLAST
Domaini1901 – 2076176DH 2PROSITE-ProRule annotationAdd
BLAST
Domaini2088 – 2198111PH 2PROSITE-ProRule annotationAdd
BLAST
Domaini2293 – 235866SH3 2PROSITE-ProRule annotationAdd
BLAST
Domaini2444 – 253794Ig-like C2-typeAdd
BLAST
Domaini2544 – 263895Fibronectin type-IIIPROSITE-ProRule annotationAdd
BLAST
Domaini2657 – 2911255Protein kinasePROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi664 – 6696Poly-Gln

Domaini

The two GEF domains catalyze nucleotide exchange for RAC1 and RhoA which are bound by DH1 and DH2 respectively. The two GEF domains appear to play differing roles in neuronal development and axonal outgrowth. SH3 1 binds to the first GEF domain inhibiting GEF activity only when in the presence of a PXXP peptide, suggesting that the SH3 domain/peptide interaction mediates binding to GEF1. CRK1 SH3 domain binds to and inhibits GEF1 activity.2 Publications

Sequence similaritiesi

Contains 1 CRAL-TRIO domain.PROSITE-ProRule annotation
Contains 2 DH (DBL-homology) domains.PROSITE-ProRule annotation
Contains 1 fibronectin type-III domain.PROSITE-ProRule annotation
Contains 2 PH domains.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation
Contains 2 SH3 domains.PROSITE-ProRule annotation
Contains 9 spectrin repeats.Sequence analysis

Keywords - Domaini

Immunoglobulin domain, Repeat, SH3 domain

Phylogenomic databases

eggNOGiKOG0032. Eukaryota.
KOG0613. Eukaryota.
KOG4240. Eukaryota.
ENOG410XPCA. LUCA.
GeneTreeiENSGT00760000119030.
HOVERGENiHBG108598.
InParanoidiP97924.
KOiK15048.
PhylomeDBiP97924.

Family and domain databases

Gene3Di1.20.900.10. 2 hits.
2.30.29.30. 2 hits.
2.60.40.10. 2 hits.
3.40.525.10. 1 hit.
InterProiIPR001251. CRAL-TRIO_dom.
IPR000219. DH-domain.
IPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR028569. Kalirin.
IPR011009. Kinase-like_dom.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR001452. SH3_domain.
IPR018159. Spectrin/alpha-actinin.
IPR002017. Spectrin_repeat.
[Graphical view]
PANTHERiPTHR22826:SF49. PTHR22826:SF49. 3 hits.
PfamiPF00650. CRAL_TRIO. 1 hit.
PF00041. fn3. 1 hit.
PF07679. I-set. 1 hit.
PF00169. PH. 1 hit.
PF00069. Pkinase. 1 hit.
PF00621. RhoGEF. 2 hits.
PF00018. SH3_1. 1 hit.
PF00435. Spectrin. 4 hits.
[Graphical view]
SMARTiSM00060. FN3. 1 hit.
SM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
SM00233. PH. 2 hits.
SM00325. RhoGEF. 2 hits.
SM00220. S_TKc. 1 hit.
SM00516. SEC14. 1 hit.
SM00326. SH3. 2 hits.
SM00150. SPEC. 7 hits.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 2 hits.
SSF48726. SSF48726. 1 hit.
SSF49265. SSF49265. 1 hit.
SSF50044. SSF50044. 2 hits.
SSF50729. SSF50729. 2 hits.
SSF52087. SSF52087. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50191. CRAL_TRIO. 1 hit.
PS50010. DH_2. 2 hits.
PS50853. FN3. 1 hit.
PS50835. IG_LIKE. 1 hit.
PS50003. PH_DOMAIN. 2 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequences (8)i

Sequence statusi: Complete.

This entry describes 8 isoformsi produced by alternative splicing and alternative initiation. AlignAdd to basket

Isoform 1 (identifier: P97924-1) [UniParc]FASTAAdd to basket
Also known as: Kalirin-12A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVLSGSFRND GLKASDVLPI LKEKVAFVSG GRDKRGGPIL TFPARTNHDR
60 70 80 90 100
IRQEDLRKLV TNLASVPSED VCKRGFTVII DMRGSKWDLI KPLLKTLQEA
110 120 130 140 150
FPAEIHVALI IKPDNFWQKQ KTNFGSSKFI FETSMVSVEG LTKLVDPSQL
160 170 180 190 200
TEEFDGSLDY NHEEWIELRL SLEEFFNSAV HLLSRLEDLQ EMLARKEFPV
210 220 230 240 250
DVEGSRRLID EHTQLKKKVL KAPVEELDRE GQRLLQCIRC SDGFSGRNCI
260 270 280 290 300
PGSADFQSLV PKITSLLDKL HSTRQHLHQM WHVRKLKLDQ CFQLRLFEQD
310 320 330 340 350
AEKMFDWISH NKELFLQSHT EIGVSYQHAL DLQTQHNHFA MNSMNAYVNI
360 370 380 390 400
NRIMSVASRL SEAGHYASQQ IKQISTQLDQ EWKSFAAALD ERSTILAMSA
410 420 430 440 450
VFHQKAEQFL SGVDAWCKMC SEGGLPSEMQ DLELAIHHHQ SLYEQVTQAY
460 470 480 490 500
TEVSQDGKAL LDVLQRPLSP GNSESLTATA NYSKAVHQVL DVVHEVLHHQ
510 520 530 540 550
RRLESIWQHR KVRLHQRLQL CVFQQDVQQV LDWIENHGEA FLSKHTGVGK
560 570 580 590 600
SLHRARALQK RHDDFEEVAQ NTYTNADKLL EAAEQLAQTG ECDPEEIYKA
610 620 630 640 650
ARHLEVRIQD FVRRVEQRKL LLDMSVSFHT HTKELWTWME DLQKEVLEDV
660 670 680 690 700
CADSVDAVQE LIKQFQQQQT ATLDATLNVI KEGEDLIQQL RSAPPSLGEP
710 720 730 740 750
TEARDSAVSN NKTPHSSSIS HIESVLQQLD DAQVQMEELF HERKIKLDIF
760 770 780 790 800
LQLRIFEQYT IEVTAELDAW NEDLLRQMND FNTEDLTLAE QRLQRHTERK
810 820 830 840 850
LAMNNMTFEV IQQGQDLHQY IMEVQASGIE LICEKDVDLA AQVQELLEFL
860 870 880 890 900
HEKQHELELN AEQTHKRLEQ CLQLRHLQAE VKQVLGWIRN GESMLNASLV
910 920 930 940 950
NASSLSEAEQ LQREHEQFQL AIEKTHQSAL QVQQKAEALL QAGHYDADAI
960 970 980 990 1000
RECAEKVALH WQQLMLKMED RLKLVNASVA FYKTSEQVCS VLESLEQEYR
1010 1020 1030 1040 1050
RDEDWCGGRD KLGPAAEMDH VIPLLSKHLE QKEAFLKACT LARRNAEVFL
1060 1070 1080 1090 1100
KYIHRNNVSM PSVASHTRGP EQQVKAILSE LLQRENRVLH FWTLKKRRLD
1110 1120 1130 1140 1150
QCQQYVVFER SAKQALDWIQ ETGEYYLSTH TSTGETTEET QELLKEYGEF
1160 1170 1180 1190 1200
RVPAKQTKEK VKLLIQLADS FVEKGHIHAT EIRKWVTTVD KHYRDFSLRM
1210 1220 1230 1240 1250
GKYRYTLEKA LGVNTEDNKD LELDIIPASL SDREVKLRDA NHEVNEEKRK
1260 1270 1280 1290 1300
SARKKEFIMA ELLQTEKAYV RDLHECLETY LWEMTSGVEE IPPGILNKEH
1310 1320 1330 1340 1350
IIFGNIQEIY DFHNNIFLKE LEKYEQLPED VGHCFVTWAD KFQMYVTYCK
1360 1370 1380 1390 1400
NKPDSNQLIL EHAGTFFDEI QQRHGLANSI SSYLIKPVQR VTKYQLLLKE
1410 1420 1430 1440 1450
LLTCCEEGKG ELKDGLEVML SVPKKANDAM HVSMLEGFDE NLDVQGELIL
1460 1470 1480 1490 1500
QDAFQVWDPK SLIRKGRERH LFLFEISLVF SKEIKDSSGH TKYVYKNKLL
1510 1520 1530 1540 1550
TSELGVTEHV EGDPCKFALW SGRTPSSDNK TVLKASNIET KQEWIKNIRE
1560 1570 1580 1590 1600
VIQERIIHLK GALKEPIQLP KTPAKLRNNS KRDGVEDGDS QGDGSSQPDT
1610 1620 1630 1640 1650
ISIASRTSQN TVESDKLSGG CELTVVLQDF SAAHSSELSI QVGQTVELLE
1660 1670 1680 1690 1700
RPSERPGWCL VRTTERSPPQ EGLVPSSTLC ISHSRSSVEM DCFFPLVKDS
1710 1720 1730 1740 1750
YSHSSGENGG KSESVANLQS QPSLNSIHSS PGPKRSTNTL KKWLTSPVRR
1760 1770 1780 1790 1800
LNSGKADGNI KKQKKVRDGR KSFDLGSPKP GDETTPQGDS ADEKSKKGWG
1810 1820 1830 1840 1850
EDEPDEESHT PLPPPMKIFD NDPTQDEMSS LLAARQAPTD VPTAADLVSA
1860 1870 1880 1890 1900
IEKLVKSKLT LEGGSYRGSL KDPTVCLNEG MAPPTPPRNL EEEQKAKALR
1910 1920 1930 1940 1950
GRMFVLNELV QTEKDYVKDL GIVVEGFMKR IEEKGVPEDM RGKEKIVFGN
1960 1970 1980 1990 2000
IHQIYDWHKD FFLAELEKCI QEQDRLAQLF IKHERKLHIY VWYCQNKPRS
2010 2020 2030 2040 2050
EYIVAEYDAY FEEVKQEINQ RLTLSDFLIK PIQRITKYQL LLKDFLRYSE
2060 2070 2080 2090 2100
KAGLECSDIE KAVELMCLVP KRCNDMMNLG RLQGFEGTLT AQGKLLQQDT
2110 2120 2130 2140 2150
FYVIELDAGM QSRTKERRVF LFEQIVIFSE LLRKGSLTPG YMFKRSIKMN
2160 2170 2180 2190 2200
YLVLEEDVDD DPCKFALMNR ETSERVILQA ANSDIQQAWV QDINQVLETQ
2210 2220 2230 2240 2250
RDFLNALQSP IEYQRKERST AVIRSQPPRV PQASPRPYSS VPVGSEKPPK
2260 2270 2280 2290 2300
GSSYNPPLPP LKISTSNGSP GFDYHQPGDK FDASKQNDLG GCNGTSTMAV
2310 2320 2330 2340 2350
IKDYYALKEN EICVSQGEVV QVLAVNQQNM CLVYQPASDH SPAAEGWVPG
2360 2370 2380 2390 2400
SILAPLTKAT APAESSDESI KKSCSWHTLR MRKRADVENT GKNEATGPRK
2410 2420 2430 2440 2450
PKDILGNKAS VKETNSSEES ECDDLDPNTS MEILNPNFIQ EVAPEFLVPL
2460 2470 2480 2490 2500
VDVTCLLGDT VLLQCKACGR PKPTITWKGP DQNILDTDNS SATYTISSCD
2510 2520 2530 2540 2550
SGESTLKICN LMPQDSGIYT CIATNDHGTA STSATVKVQG VPAAPNRPIA
2560 2570 2580 2590 2600
QERSCTSVIL RWLPPASTGN CTISGYTVEY REEGSQVWQQ SVASTLDTYL
2610 2620 2630 2640 2650
VIEDLSPGCP YQFRVSASNP WGISLPSEPS EFVHLPEYDA AADGATISWK
2660 2670 2680 2690 2700
ENFDSAYTEL NEIGRGRFSI VKKCIHKATR KDVAVKFVSK KMKKKEQAAH
2710 2720 2730 2740 2750
EAALLQHLQH PQYVTLHDTY ESPTSYILIL ELMDDGRLLD YLMNHDELME
2760 2770 2780 2790 2800
EKVAFYIRDI MEALQYLHNC RVAHLDIKPE NLLIDLRIPV PRVKLIDLED
2810 2820 2830 2840 2850
AVQISGHFHI HHLLGNPEFA APEVIQGIPV SLGTDIWSIG VLTYVMLSGV
2860 2870 2880 2890 2900
SPFLDESKEE TCINVCRVDF SFPHEYFCGV SNAARDFINV ILQEDFRRRP
2910 2920 2930 2940 2950
TAATCLQHPW LQPHNGSYSK IPLDTSRLAC FIERRKHQND VRPIPNVKSY

IVNRVNQGT
Note: Produced by alternative splicing.
Length:2,959
Mass (Da):336,587
Last modified:October 23, 2007 - v3
Checksum:i1A3C6770D1CBCC1F
GO
Isoform 2 (identifier: P97924-2) [UniParc]FASTAAdd to basket
Also known as: Kalirin-8B, P-CIP10B

The sequence of this isoform differs from the canonical sequence as follows:
     1-4: MVLS → MNPPEGASEEGGAADSDVDAFFRT
     1860-1899: TLEGGSYRGS...LEEEQKAKAL → VSGHAGGSRV...HPDFVYSNCI
     1900-2959: Missing.

Note: Produced by alternative splicing.
Show »
Length:1,919
Mass (Da):218,841
Checksum:iE4DBB818E890F453
GO
Isoform 3 (identifier: P97924-3) [UniParc]FASTAAdd to basket
Also known as: Kalirin-8A, P-CIP10A

The sequence of this isoform differs from the canonical sequence as follows:
     1860-1899: TLEGGSYRGS...LEEEQKAKAL → VSGHAGGSRV...HPDFVYSNCI
     1900-2959: Missing.

Note: Produced by alternative splicing.
Show »
Length:1,899
Mass (Da):216,819
Checksum:iE3545E4CB9F59A1E
GO
Isoform 4 (identifier: P97924-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     923-923: E → ESLFHATSLQ

Note: Produced by alternative splicing.
Show »
Length:2,968
Mass (Da):337,572
Checksum:i6B8B3C0E9FD8CDDC
GO
Isoform 5 (identifier: P97924-5) [UniParc]FASTAAdd to basket
Also known as: Delta Kalirin-7

The sequence of this isoform differs from the canonical sequence as follows:
     1-623: Missing.
     1617-1636: LSGGCELTVVLQDFSAAHSS → DGNLVPRWHLGPGDPFSTYV
     1637-2959: Missing.

Note: Produced by alternative initiation at Met-624 of isoform 6.
Show »
Length:1,013
Mass (Da):116,939
Checksum:i8C24887FBE316B64
GO
Isoform 6 (identifier: P97924-6) [UniParc]FASTAAdd to basket
Also known as: Kalirin-7, Kalirin-7c, HAPIP

The sequence of this isoform differs from the canonical sequence as follows:
     1-4: MVLS → MTDRFWDQWYLWYLRLLRLLDR
     1617-1636: LSGGCELTVVLQDFSAAHSS → DGNLVPRWHLGPGDPFSTYV
     1637-2959: Missing.

Note: Produced by alternative splicing.
Show »
Length:1,654
Mass (Da):191,116
Checksum:iC2C267C2226EF596
GO
Isoform 7 (identifier: P97924-7) [UniParc]FASTAAdd to basket
Also known as: Kalirin-9A

The sequence of this isoform differs from the canonical sequence as follows:
     2372-2376: KSCSW → TLLKP
     2377-2959: Missing.

Note: Produced by alternative splicing.
Show »
Length:2,376
Mass (Da):271,353
Checksum:i3AEC5B08F483E75C
GO
Isoform 8 (identifier: P97924-8) [UniParc]FASTAAdd to basket
Also known as: Kalirin-4a

The sequence of this isoform differs from the canonical sequence as follows:
     705-718: DSAVSNNKTPHSSS → SAWAVIPVGNASG
     719-2959: Missing.

Note: Produced by alternative splicing.
Show »
Length:717
Mass (Da):81,973
Checksum:i08AB2C8397ED9654
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti46 – 461T → S in AAT39517 (PubMed:15950621).Curated
Sequence conflicti62 – 621N → Y in AAT39517 (PubMed:15950621).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 623623Missing in isoform 5. 1 PublicationVSP_028893Add
BLAST
Alternative sequencei1 – 44MVLS → MNPPEGASEEGGAADSDVDA FFRT in isoform 2. 2 PublicationsVSP_028891
Alternative sequencei1 – 44MVLS → MTDRFWDQWYLWYLRLLRLL DR in isoform 6. 1 PublicationVSP_028892
Alternative sequencei705 – 71814DSAVS…PHSSS → SAWAVIPVGNASG in isoform 8. 1 PublicationVSP_028894Add
BLAST
Alternative sequencei719 – 29592241Missing in isoform 8. 1 PublicationVSP_028895Add
BLAST
Alternative sequencei923 – 9231E → ESLFHATSLQ in isoform 4. 1 PublicationVSP_028896
Alternative sequencei1617 – 163620LSGGC…AAHSS → DGNLVPRWHLGPGDPFSTYV in isoform 5 and isoform 6. 2 PublicationsVSP_028897Add
BLAST
Alternative sequencei1637 – 29591323Missing in isoform 5 and isoform 6. 2 PublicationsVSP_028898Add
BLAST
Alternative sequencei1860 – 189940TLEGG…KAKAL → VSGHAGGSRVLPLTSMWLPG PQLGPQISYLHPDFVYSNCI in isoform 2 and isoform 3. 2 PublicationsVSP_028899Add
BLAST
Alternative sequencei1900 – 29591060Missing in isoform 2 and isoform 3. 2 PublicationsVSP_028900Add
BLAST
Alternative sequencei2372 – 23765KSCSW → TLLKP in isoform 7. 1 PublicationVSP_028901
Alternative sequencei2377 – 2959583Missing in isoform 7. 1 PublicationVSP_028902Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U88156 mRNA. Translation: AAB66366.1.
U88157 mRNA. Translation: AAB66367.1.
AF230644 mRNA. Translation: AAF69144.1.
AF229255 mRNA. Translation: AAF66014.1.
AF232668 mRNA. Translation: AAF66018.1.
AF232669 mRNA. Translation: AAF66019.1.
AY621095 mRNA. Translation: AAT39517.1.
U94189 mRNA. Translation: AAC15790.1.
PIRiT32732.
T42098.
RefSeqiNP_114451.2. NM_032062.2.
UniGeneiRn.87882.

Genome annotation databases

EnsembliENSRNOT00000016340; ENSRNOP00000016340; ENSRNOG00000001706. [P97924-5]
GeneIDi84009.
KEGGirno:84009.
UCSCiRGD:621865. rat. [P97924-1]

Keywords - Coding sequence diversityi

Alternative initiation, Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U88156 mRNA. Translation: AAB66366.1.
U88157 mRNA. Translation: AAB66367.1.
AF230644 mRNA. Translation: AAF69144.1.
AF229255 mRNA. Translation: AAF66014.1.
AF232668 mRNA. Translation: AAF66018.1.
AF232669 mRNA. Translation: AAF66019.1.
AY621095 mRNA. Translation: AAT39517.1.
U94189 mRNA. Translation: AAC15790.1.
PIRiT32732.
T42098.
RefSeqiNP_114451.2. NM_032062.2.
UniGeneiRn.87882.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1U3ONMR-A1617-1686[»]
2KR9NMR-A1253-1432[»]
ProteinModelPortaliP97924.
SMRiP97924. Positions 1252-1555, 1618-1684, 1891-2220, 2297-2361.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP97924. 3 interactions.
MINTiMINT-159104.
STRINGi10116.ENSRNOP00000039072.

Chemistry

ChEMBLiCHEMBL2176786.

PTM databases

iPTMnetiP97924.
PhosphoSiteiP97924.

Proteomic databases

PaxDbiP97924.
PRIDEiP97924.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000016340; ENSRNOP00000016340; ENSRNOG00000001706. [P97924-5]
GeneIDi84009.
KEGGirno:84009.
UCSCiRGD:621865. rat. [P97924-1]

Organism-specific databases

CTDi8997.
RGDi621865. Kalrn.

Phylogenomic databases

eggNOGiKOG0032. Eukaryota.
KOG0613. Eukaryota.
KOG4240. Eukaryota.
ENOG410XPCA. LUCA.
GeneTreeiENSGT00760000119030.
HOVERGENiHBG108598.
InParanoidiP97924.
KOiK15048.
PhylomeDBiP97924.

Enzyme and pathway databases

ReactomeiR-RNO-193648. NRAGE signals death through JNK.
R-RNO-194840. Rho GTPase cycle.
R-RNO-3928662. EPHB-mediated forward signaling.
R-RNO-416476. G alpha (q) signalling events.
R-RNO-416482. G alpha (12/13) signalling events.
R-RNO-5687128. MAPK6/MAPK4 signaling.

Miscellaneous databases

EvolutionaryTraceiP97924.
PROiP97924.

Gene expression databases

ExpressionAtlasiP97924. baseline and differential.

Family and domain databases

Gene3Di1.20.900.10. 2 hits.
2.30.29.30. 2 hits.
2.60.40.10. 2 hits.
3.40.525.10. 1 hit.
InterProiIPR001251. CRAL-TRIO_dom.
IPR000219. DH-domain.
IPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR028569. Kalirin.
IPR011009. Kinase-like_dom.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR001452. SH3_domain.
IPR018159. Spectrin/alpha-actinin.
IPR002017. Spectrin_repeat.
[Graphical view]
PANTHERiPTHR22826:SF49. PTHR22826:SF49. 3 hits.
PfamiPF00650. CRAL_TRIO. 1 hit.
PF00041. fn3. 1 hit.
PF07679. I-set. 1 hit.
PF00169. PH. 1 hit.
PF00069. Pkinase. 1 hit.
PF00621. RhoGEF. 2 hits.
PF00018. SH3_1. 1 hit.
PF00435. Spectrin. 4 hits.
[Graphical view]
SMARTiSM00060. FN3. 1 hit.
SM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
SM00233. PH. 2 hits.
SM00325. RhoGEF. 2 hits.
SM00220. S_TKc. 1 hit.
SM00516. SEC14. 1 hit.
SM00326. SH3. 2 hits.
SM00150. SPEC. 7 hits.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 2 hits.
SSF48726. SSF48726. 1 hit.
SSF49265. SSF49265. 1 hit.
SSF50044. SSF50044. 2 hits.
SSF50729. SSF50729. 2 hits.
SSF52087. SSF52087. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50191. CRAL_TRIO. 1 hit.
PS50010. DH_2. 2 hits.
PS50853. FN3. 1 hit.
PS50835. IG_LIKE. 1 hit.
PS50003. PH_DOMAIN. 2 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKALRN_RAT
AccessioniPrimary (citable) accession number: P97924
Secondary accession number(s): O70135
, Q6IV51, Q9JIF1, Q9JIF2, Q9JIG0, Q9JIH3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: October 23, 2007
Last modified: July 6, 2016
This is version 156 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Called DUO because the encoded protein is closely related to but shorter than TRIO.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.