P97888 (2ABG_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform

Alternative name(s):
PP2A subunit B isoform B55-gamma
PP2A subunit B isoform BRgamma
PP2A subunit B isoform PR55-gamma
PP2A subunit B isoform R2-gamma
PP2A subunit B isoform gamma

Gene names

Name:

Ppp2r2c

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	447 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.
Subunit structure	PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules.
Tissue specificity	Highly expressed in brain.
Sequence similarities	Belongs to the phosphatase 2A regulatory subunit B family. Contains 7 WD repeats.

Ontologies

Keywords
Domain	Repeat WD repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	signal transduction Inferred from electronic annotation. Source: InterPro
Cellular_component	protein phosphatase type 2A complex Inferred from electronic annotation. Source: InterPro
Molecular_function	protein phosphatase type 2A regulator activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 447	447	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform		PRO_0000071432
Regions
	Repeat	22 – 61	40	WD 1
	Repeat	87 – 128	42	WD 2
	Repeat	171 – 209	39	WD 3
	Repeat	220 – 260	41	WD 4
	Repeat	279 – 317	39	WD 5
	Repeat	334 – 375	42	WD 6
	Repeat	410 – 446	37	WD 7

Sequences

	Sequence		Length	Mass (Da)
	P97888 [UniParc]. Last modified May 1, 1997. Version 1. Checksum: DE16E4EFC775F3C5	FASTA	447	51,474
	10 20 30 40 50 60 MGEDTDTRKI NHSFLRDHSY VTEADVISTV EFNHTGELLA TGDKGGRVVI FQREPESKNA 70 80 90 100 110 120 PHSQGEYDVY STFQSHEPEF DYLKSLEIEE KINKIKWLPQ QNAAHSLLST NDKTIKLWKI 130 140 150 160 170 180 TERDKRPEGY NLKDEEGKLK DLSTVTSLQV PVLKPMDLMV EVSPRRIFAN GHTYHINSIS 190 200 210 220 230 240 VNSDCETYMS ADDLRINLWH LAITDRSFNI VDIKPANMED LTEVITASEF HPHHCNLFVY 250 260 270 280 290 300 SSSKGSLRLC DMRAAALCDK HSKLFEEPED PSNRSFFSEI ISSVSDVKFS HSGRYMLTRD 310 320 330 340 350 360 YLTVKVWDLN MEARPIETYQ VHDYLRSKLC SLYESDCIFD KFECAWNGSD SVIMTGAYNN 370 380 390 400 410 420 FFRMFDRNTK RDVTLEASRE SSKPRAVLKP RRVCVGGKRR RDDISVDSLD FTKKILHTAW 430 440 HPAENIIAIA ATNNLYIFQD KVNSDMH

References

[1]	"cDNA cloning of BR gamma, a novel brain-specific isoform of the B regulatory subunit of type-2A protein phosphatase." Akiyama N., Shima H., Hatano Y., Osawa Y., Sugimura T., Nagao M. Eur. J. Biochem. 230:766-772(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Sprague-Dawley. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D38261 mRNA. Translation: BAA07413.1.
IPI	IPI00208863.
RefSeq	NP_476457.1. NM_057116.1.
UniGene	Rn.54550.
3D structure databases
ProteinModelPortal	P97888.
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000055280.
Proteomic databases
PaxDb	P97888.
PRIDE	P97888.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	117256.
KEGG	rno:117256.
Organism-specific databases
CTD	5522.
RGD	620920. Ppp2r2c.
Phylogenomic databases
eggNOG	COG5170.
HOVERGEN	HBG000012.
KO	K04354.
Gene expression databases
Genevestigator	P97888.
Family and domain databases
Gene3D	2.130.10.10. 1 hit.
InterPro	IPR000009. PP2A_PR55. IPR018067. PP2A_PR55_CS. IPR015943. WD40/YVTN_repeat-like_dom. IPR001680. WD40_repeat. IPR017986. WD40_repeat_dom. [Graphical view]
PANTHER	PTHR11871. PTHR11871. 1 hit.
PIRSF	PIRSF037309. PP2A_PR55. 1 hit.
PRINTS	PR00600. PP2APR55.
SMART	SM00320. WD40. 6 hits. [Graphical view]
SUPFAM	SSF50978. WD40_like. 1 hit.
PROSITE	PS01024. PR55_1. 1 hit. PS01025. PR55_2. 1 hit. PS00678. WD_REPEATS_1. False negative. PS50082. WD_REPEATS_2. False negative. PS50294. WD_REPEATS_REGION. False negative. [Graphical view]
ProtoNet	Search...
Other
NextBio	620116.

Entry information

Entry name

2ABG_RAT

Accession

Primary (citable) accession number: P97888

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	May 1, 1997
Last modified:	April 3, 2013
This is version 87 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program