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Protein

C-X-C motif chemokine 5

Gene

Cxcl5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

May participate in the recruitment of inflammatory cells by injured or infected tissue.By similarity

GO - Molecular functioni

  • chemokine activity Source: RGD
  • CXCR chemokine receptor binding Source: GO_Central

GO - Biological processi

  • animal organ regeneration Source: RGD
  • cellular response to lipopolysaccharide Source: RGD
  • chemokine-mediated signaling pathway Source: GO_Central
  • cytokine production Source: RGD
  • G-protein coupled receptor signaling pathway Source: GO_Central
  • immune response Source: GO_Central
  • inflammatory response Source: RGD
  • midbrain development Source: RGD
  • neutrophil mediated immunity Source: GO_Central
  • positive regulation of JAK-STAT cascade Source: RGD
  • positive regulation of leukocyte chemotaxis Source: GO_Central
  • positive regulation of neuron projection development Source: RGD
  • regulation of cell proliferation Source: GO_Central
  • response to gamma radiation Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Names & Taxonomyi

Protein namesi
Recommended name:
C-X-C motif chemokine 5
Alternative name(s):
Cytokine LIX
Small-inducible cytokine B5
Gene namesi
Name:Cxcl5
Synonyms:Scyb5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi708540. Cxcl5.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 37By similarityAdd BLAST37
ChainiPRO_000000508138 – 130C-X-C motif chemokine 5Add BLAST93

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi50 ↔ 76By similarity
Disulfide bondi52 ↔ 93By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP97885.
PRIDEiP97885.

PTM databases

PhosphoSitePlusiP97885.

Interactioni

GO - Molecular functioni

  • chemokine activity Source: RGD
  • CXCR chemokine receptor binding Source: GO_Central

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003823.

Structurei

3D structure databases

ProteinModelPortaliP97885.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J4TR. Eukaryota.
ENOG41117DC. LUCA.
HOGENOMiHOG000220915.
HOVERGENiHBG107789.
InParanoidiP97885.
KOiK05506.
PhylomeDBiP97885.

Family and domain databases

CDDicd00273. Chemokine_CXC. 1 hit.
InterProiIPR001089. Chemokine_CXC.
IPR018048. Chemokine_CXC_CS.
IPR001811. Chemokine_IL8-like_dom.
IPR033899. CXC_Chemokine_domain.
[Graphical view]
PANTHERiPTHR10179. PTHR10179. 1 hit.
PfamiPF00048. IL8. 1 hit.
[Graphical view]
PRINTSiPR00437. SMALLCYTKCXC.
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00471. SMALL_CYTOKINES_CXC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P97885-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFQLRSSAR IPSRSCSSFT LLAFLLLFTL PQHRAQAAPF SAMVATELRC
60 70 80 90 100
VCLTLAPRIN PKMIANLEVI PAGPHCPKVE VIAKLKNQKD NVCLDPQAPL
110 120 130
IKKVIQKILG SENKKTKRNA LALVRSASTQ
Length:130
Mass (Da):14,263
Last modified:May 1, 1997 - v1
Checksum:iC00F6B3605524F4E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U90448 mRNA. Translation: AAB61460.1.
RefSeqiNP_071550.1. NM_022214.1.
UniGeneiRn.44449.

Genome annotation databases

GeneIDi60665.
KEGGirno:60665.
UCSCiRGD:708540. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U90448 mRNA. Translation: AAB61460.1.
RefSeqiNP_071550.1. NM_022214.1.
UniGeneiRn.44449.

3D structure databases

ProteinModelPortaliP97885.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003823.

PTM databases

PhosphoSitePlusiP97885.

Proteomic databases

PaxDbiP97885.
PRIDEiP97885.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi60665.
KEGGirno:60665.
UCSCiRGD:708540. rat.

Organism-specific databases

CTDi6372.
RGDi708540. Cxcl5.

Phylogenomic databases

eggNOGiENOG410J4TR. Eukaryota.
ENOG41117DC. LUCA.
HOGENOMiHOG000220915.
HOVERGENiHBG107789.
InParanoidiP97885.
KOiK05506.
PhylomeDBiP97885.

Miscellaneous databases

PROiP97885.

Family and domain databases

CDDicd00273. Chemokine_CXC. 1 hit.
InterProiIPR001089. Chemokine_CXC.
IPR018048. Chemokine_CXC_CS.
IPR001811. Chemokine_IL8-like_dom.
IPR033899. CXC_Chemokine_domain.
[Graphical view]
PANTHERiPTHR10179. PTHR10179. 1 hit.
PfamiPF00048. IL8. 1 hit.
[Graphical view]
PRINTSiPR00437. SMALLCYTKCXC.
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00471. SMALL_CYTOKINES_CXC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCXCL5_RAT
AccessioniPrimary (citable) accession number: P97885
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: November 30, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.