ID   CCL20_RAT               Reviewed;          96 AA.
AC   P97884;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1997, sequence version 1.
DT   27-MAR-2024, entry version 146.
DE   RecName: Full=C-C motif chemokine 20;
DE   AltName: Full=Beta-chemokine exodus-1;
DE   AltName: Full=CC chemokine LARC;
DE   AltName: Full=CC chemokine ST38;
DE   AltName: Full=Liver and activation-regulated chemokine;
DE   AltName: Full=Macrophage inflammatory protein 3 alpha;
DE            Short=MIP-3-alpha;
DE   AltName: Full=Small-inducible cytokine A20;
DE   Flags: Precursor;
GN   Name=Ccl20; Synonyms=Scya20, St38;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Sprague-Dawley;
RA   Kelner G.S., Maciejewski-Lenoir D., Lee E.D., Maki R.A.;
RT   "Activated rat astrocytes produce the CC chemokine Exodus.";
RL   Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND PROTEIN SEQUENCE OF N-TERMINUS.
RC   STRAIN=Fischer 344; TISSUE=Brain;
RX   PubMed=9916893; DOI=10.1016/s0165-5728(98)00204-5;
RA   Utans-Schneitz U., Lorez H., Klinkert W.E.F., da Silva J., Lesslauer W.;
RT   "A novel rat CC chemokine, identified by targeted differential display, is
RT   upregulated in brain inflammation.";
RL   J. Neuroimmunol. 92:179-190(1998).
CC   -!- FUNCTION: Acts as a ligand for C-C chemokine receptor CCR6. Signals
CC       through binding and activation of CCR6 and induces a strong chemotactic
CC       response and mobilization of intracellular calcium ions. The ligand-
CC       receptor pair CCL20-CCR6 is responsible for the chemotaxis of dendritic
CC       cells (DC), effector/memory T-cells and B-cells and plays an important
CC       role at skin and mucosal surfaces under homeostatic and inflammatory
CC       conditions, as well as in pathology, including cancer and autoimmune
CC       diseases. CCL20 acts as a chemotactic factor that attracts lymphocytes
CC       and, slightly, neutrophils, but not monocytes. Involved in the
CC       recruitment of both the pro-inflammatory IL17 producing helper T-cells
CC       (Th17) and the regulatory T-cells (Treg) to sites of inflammation.
CC       Required for optimal migration of thymic natural regulatory T cells
CC       (nTregs) and DN1 early thymocyte progenitor cells. Positively regulates
CC       sperm motility and chemotaxis via its binding to CCR6 which triggers
CC       Ca2+ mobilization in the sperm which is important for its motility. May
CC       be involved in formation and function of the mucosal lymphoid tissues
CC       by attracting lymphocytes and dendritic cells towards epithelial cells.
CC       {ECO:0000250|UniProtKB:O89093, ECO:0000250|UniProtKB:P78556}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P78556}.
CC   -!- TISSUE SPECIFICITY: Low levels in thymus and lung.
CC   -!- INDUCTION: By TNF in experimental allergic panencaphalomyelitis (EAP)
CC       and by TNF and IL-1 in primary astrocytes.
CC   -!- SIMILARITY: Belongs to the intercrine beta (chemokine CC) family.
CC       {ECO:0000305}.
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DR   EMBL; U90447; AAB61459.1; -; mRNA.
DR   EMBL; AF053312; AAC78294.1; -; mRNA.
DR   RefSeq; NP_062106.1; NM_019233.1.
DR   AlphaFoldDB; P97884; -.
DR   SMR; P97884; -.
DR   STRING; 10116.ENSRNOP00000021730; -.
DR   PaxDb; 10116-ENSRNOP00000021730; -.
DR   GeneID; 29538; -.
DR   KEGG; rno:29538; -.
DR   UCSC; RGD:3646; rat.
DR   AGR; RGD:3646; -.
DR   CTD; 6364; -.
DR   RGD; 3646; Ccl20.
DR   VEuPathDB; HostDB:ENSRNOG00000015992; -.
DR   HOGENOM; CLU_141716_3_3_1; -.
DR   InParanoid; P97884; -.
DR   OrthoDB; 5353157at2759; -.
DR   PhylomeDB; P97884; -.
DR   TreeFam; TF334888; -.
DR   Reactome; R-RNO-380108; Chemokine receptors bind chemokines.
DR   Reactome; R-RNO-418594; G alpha (i) signalling events.
DR   PRO; PR:P97884; -.
DR   Proteomes; UP000002494; Chromosome 9.
DR   Bgee; ENSRNOG00000015992; Expressed in duodenum and 12 other cell types or tissues.
DR   GO; GO:0005615; C:extracellular space; IDA:RGD.
DR   GO; GO:0048020; F:CCR chemokine receptor binding; IBA:GO_Central.
DR   GO; GO:0031731; F:CCR6 chemokine receptor binding; ISS:UniProtKB.
DR   GO; GO:0008009; F:chemokine activity; IDA:RGD.
DR   GO; GO:0005125; F:cytokine activity; ISO:RGD.
DR   GO; GO:0035584; P:calcium-mediated signaling using intracellular calcium source; ISS:UniProtKB.
DR   GO; GO:0060326; P:cell chemotaxis; ISO:RGD.
DR   GO; GO:0071347; P:cellular response to interleukin-1; IBA:GO_Central.
DR   GO; GO:0071222; P:cellular response to lipopolysaccharide; IEP:RGD.
DR   GO; GO:0071223; P:cellular response to lipoteichoic acid; IEP:RGD.
DR   GO; GO:0071310; P:cellular response to organic substance; IEP:RGD.
DR   GO; GO:0071356; P:cellular response to tumor necrosis factor; IBA:GO_Central.
DR   GO; GO:0071346; P:cellular response to type II interferon; IBA:GO_Central.
DR   GO; GO:0070098; P:chemokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0006935; P:chemotaxis; IDA:RGD.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR   GO; GO:0048247; P:lymphocyte chemotaxis; IBA:GO_Central.
DR   GO; GO:0002548; P:monocyte chemotaxis; IBA:GO_Central.
DR   GO; GO:0030593; P:neutrophil chemotaxis; IBA:GO_Central.
DR   GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IBA:GO_Central.
DR   GO; GO:0032730; P:positive regulation of interleukin-1 alpha production; IDA:RGD.
DR   GO; GO:0051770; P:positive regulation of nitric-oxide synthase biosynthetic process; IDA:RGD.
DR   GO; GO:2000406; P:positive regulation of T cell migration; ISO:RGD.
DR   GO; GO:0072678; P:T cell migration; ISS:UniProtKB.
DR   GO; GO:0072679; P:thymocyte migration; ISS:UniProtKB.
DR   CDD; cd01119; Chemokine_CC_DCCL; 1.
DR   Gene3D; 2.40.50.40; -; 1.
DR   InterPro; IPR039809; Chemokine_b/g/d.
DR   InterPro; IPR034133; Chemokine_CC_DCCL.
DR   InterPro; IPR001811; Chemokine_IL8-like_dom.
DR   InterPro; IPR036048; Interleukin_8-like_sf.
DR   PANTHER; PTHR12015:SF108; C-C MOTIF CHEMOKINE 20; 1.
DR   PANTHER; PTHR12015; SMALL INDUCIBLE CYTOKINE A; 1.
DR   Pfam; PF00048; IL8; 1.
DR   SMART; SM00199; SCY; 1.
DR   SUPFAM; SSF54117; Interleukin 8-like chemokines; 1.
DR   Genevisible; P97884; RN.
PE   1: Evidence at protein level;
KW   Chemotaxis; Cytokine; Direct protein sequencing; Disulfide bond;
KW   Inflammatory response; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000269|PubMed:9916893"
FT   CHAIN           27..96
FT                   /note="C-C motif chemokine 20"
FT                   /id="PRO_0000005219"
FT   DISULFID        31..58
FT                   /evidence="ECO:0000250"
FT   DISULFID        32..74
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   96 AA;  10875 MW;  7B323410F2B2E6DF CRC64;
     MACKHLPFLA LAGVLLAYLC SQSEAASNFD CCLTYTKNVY HHARNFVGFT TQMADEACDI
     NAIIFHLKSK RSVCADPKQI WVKRILHLLS LRTKKM
//