Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P97884 (CCL20_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
C-C motif chemokine 20
Alternative name(s):
Beta-chemokine exodus-1
CC chemokine LARC
CC chemokine ST38
Liver and activation-regulated chemokine
Macrophage inflammatory protein 3 alpha
Short name=MIP-3-alpha
Small-inducible cytokine A20
Gene names
Name:Ccl20
Synonyms:Scya20, St38
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length96 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes By similarity. May play a role in modulating inflammatory cell recruitment to the CNS and therefore contribute to tissue injury in ischemic stroke and autoimmune diseases.

Subunit structure

Binds to and activate CCR6 By similarity.

Subcellular location

Secreted.

Tissue specificity

Low levels in thymus and lung.

Induction

By TNF in experimental allergic panencaphalomyelitis (EAP) and by TNF and IL-1 in primary astrocytes.

Sequence similarities

Belongs to the intercrine beta (chemokine CC) family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2626 Ref.2
Chain27 – 9670C-C motif chemokine 20
PRO_0000005219

Amino acid modifications

Disulfide bond31 ↔ 58 By similarity
Disulfide bond32 ↔ 74 By similarity

Sequences

Sequence LengthMass (Da)Tools
P97884 [UniParc].

Last modified May 1, 1997. Version 1.
Checksum: 7B323410F2B2E6DF

FASTA9610,875
        10         20         30         40         50         60 
MACKHLPFLA LAGVLLAYLC SQSEAASNFD CCLTYTKNVY HHARNFVGFT TQMADEACDI 

        70         80         90 
NAIIFHLKSK RSVCADPKQI WVKRILHLLS LRTKKM 

« Hide

References

[1]"Activated rat astrocytes produce the CC chemokine Exodus."
Kelner G.S., Maciejewski-Lenoir D., Lee E.D., Maki R.A.
Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Sprague-Dawley.
[2]"A novel rat CC chemokine, identified by targeted differential display, is upregulated in brain inflammation."
Utans-Schneitz U., Lorez H., Klinkert W.E.F., da Silva J., Lesslauer W.
J. Neuroimmunol. 92:179-190(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF N-TERMINUS.
Strain: Fischer 344.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U90447 mRNA. Translation: AAB61459.1.
AF053312 mRNA. Translation: AAC78294.1.
RefSeqNP_062106.1. NM_019233.1.
UniGeneRn.10722.

3D structure databases

ProteinModelPortalP97884.
SMRP97884. Positions 26-96.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000021730.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000021730; ENSRNOP00000021730; ENSRNOG00000015992.
GeneID29538.
KEGGrno:29538.
UCSCRGD:3646. rat.

Organism-specific databases

CTD6364.
RGD3646. Ccl20.

Phylogenomic databases

eggNOGNOG44269.
GeneTreeENSGT00530000064223.
HOGENOMHOG000036685.
HOVERGENHBG017871.
InParanoidP97884.
KOK14625.
OMAYHHARNF.
OrthoDBEOG7B31QP.
PhylomeDBP97884.
TreeFamTF334888.

Gene expression databases

GenevestigatorP97884.

Family and domain databases

InterProIPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamPF00048. IL8. 1 hit.
[Graphical view]
SMARTSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMSSF54117. SSF54117. 1 hit.
ProtoNetSearch...

Other

NextBio609527.
PROP97884.

Entry information

Entry nameCCL20_RAT
AccessionPrimary (citable) accession number: P97884
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: May 1, 1997
Last modified: May 14, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families