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P97884

- CCL20_RAT

UniProt

P97884 - CCL20_RAT

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Protein
C-C motif chemokine 20
Gene
Ccl20, Scya20, St38
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes By similarity. May play a role in modulating inflammatory cell recruitment to the CNS and therefore contribute to tissue injury in ischemic stroke and autoimmune diseases.

GO - Molecular functioni

  1. chemokine activity Source: RGD

GO - Biological processi

  1. cell chemotaxis Source: GOC
  2. cellular response to lipopolysaccharide Source: RGD
  3. cellular response to lipoteichoic acid Source: RGD
  4. cellular response to organic substance Source: RGD
  5. chemotaxis Source: RGD
  6. immune response Source: InterPro
  7. inflammatory response Source: UniProtKB-KW
  8. positive regulation of interleukin-1 alpha biosynthetic process Source: RGD
  9. positive regulation of nitric-oxide synthase biosynthetic process Source: RGD
  10. wound healing Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 20
Alternative name(s):
Beta-chemokine exodus-1
CC chemokine LARC
CC chemokine ST38
Liver and activation-regulated chemokine
Macrophage inflammatory protein 3 alpha
Short name:
MIP-3-alpha
Small-inducible cytokine A20
Gene namesi
Name:Ccl20
Synonyms:Scya20, St38
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 9

Organism-specific databases

RGDi3646. Ccl20.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 26261 Publication
Add
BLAST
Chaini27 – 9670C-C motif chemokine 20
PRO_0000005219Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi31 ↔ 58 By similarity
Disulfide bondi32 ↔ 74 By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Low levels in thymus and lung.

Inductioni

By TNF in experimental allergic panencaphalomyelitis (EAP) and by TNF and IL-1 in primary astrocytes.

Gene expression databases

GenevestigatoriP97884.

Interactioni

Subunit structurei

Binds to and activate CCR6 By similarity.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021730.

Structurei

3D structure databases

ProteinModelPortaliP97884.
SMRiP97884. Positions 26-96.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG44269.
GeneTreeiENSGT00530000064223.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiP97884.
KOiK14625.
OMAiYHHARNF.
OrthoDBiEOG7B31QP.
PhylomeDBiP97884.
TreeFamiTF334888.

Family and domain databases

InterProiIPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P97884-1 [UniParc]FASTAAdd to Basket

« Hide

MACKHLPFLA LAGVLLAYLC SQSEAASNFD CCLTYTKNVY HHARNFVGFT   50
TQMADEACDI NAIIFHLKSK RSVCADPKQI WVKRILHLLS LRTKKM 96
Length:96
Mass (Da):10,875
Last modified:May 1, 1997 - v1
Checksum:i7B323410F2B2E6DF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U90447 mRNA. Translation: AAB61459.1.
AF053312 mRNA. Translation: AAC78294.1.
RefSeqiNP_062106.1. NM_019233.1.
UniGeneiRn.10722.

Genome annotation databases

EnsembliENSRNOT00000021730; ENSRNOP00000021730; ENSRNOG00000015992.
GeneIDi29538.
KEGGirno:29538.
UCSCiRGD:3646. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U90447 mRNA. Translation: AAB61459.1 .
AF053312 mRNA. Translation: AAC78294.1 .
RefSeqi NP_062106.1. NM_019233.1.
UniGenei Rn.10722.

3D structure databases

ProteinModelPortali P97884.
SMRi P97884. Positions 26-96.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000021730.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000021730 ; ENSRNOP00000021730 ; ENSRNOG00000015992 .
GeneIDi 29538.
KEGGi rno:29538.
UCSCi RGD:3646. rat.

Organism-specific databases

CTDi 6364.
RGDi 3646. Ccl20.

Phylogenomic databases

eggNOGi NOG44269.
GeneTreei ENSGT00530000064223.
HOGENOMi HOG000036685.
HOVERGENi HBG017871.
InParanoidi P97884.
KOi K14625.
OMAi YHHARNF.
OrthoDBi EOG7B31QP.
PhylomeDBi P97884.
TreeFami TF334888.

Miscellaneous databases

NextBioi 609527.
PROi P97884.

Gene expression databases

Genevestigatori P97884.

Family and domain databases

InterProi IPR001811. Chemokine_IL8-like_dom.
[Graphical view ]
Pfami PF00048. IL8. 1 hit.
[Graphical view ]
SMARTi SM00199. SCY. 1 hit.
[Graphical view ]
SUPFAMi SSF54117. SSF54117. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Activated rat astrocytes produce the CC chemokine Exodus."
    Kelner G.S., Maciejewski-Lenoir D., Lee E.D., Maki R.A.
    Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
  2. "A novel rat CC chemokine, identified by targeted differential display, is upregulated in brain inflammation."
    Utans-Schneitz U., Lorez H., Klinkert W.E.F., da Silva J., Lesslauer W.
    J. Neuroimmunol. 92:179-190(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF N-TERMINUS.
    Strain: Fischer 344.
    Tissue: Brain.

Entry informationi

Entry nameiCCL20_RAT
AccessioniPrimary (citable) accession number: P97884
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: May 1, 1997
Last modified: May 14, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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