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Protein

C-C motif chemokine 20

Gene

Ccl20

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes (By similarity). May play a role in modulating inflammatory cell recruitment to the CNS and therefore contribute to tissue injury in ischemic stroke and autoimmune diseases.By similarity

GO - Molecular functioni

  1. chemokine activity Source: RGD

GO - Biological processi

  1. cell chemotaxis Source: GOC
  2. cellular response to lipopolysaccharide Source: RGD
  3. cellular response to lipoteichoic acid Source: RGD
  4. cellular response to organic substance Source: RGD
  5. chemotaxis Source: RGD
  6. immune response Source: InterPro
  7. inflammatory response Source: UniProtKB-KW
  8. positive regulation of interleukin-1 alpha biosynthetic process Source: RGD
  9. positive regulation of nitric-oxide synthase biosynthetic process Source: RGD
  10. positive regulation of T cell migration Source: Ensembl
  11. wound healing Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Enzyme and pathway databases

ReactomeiREACT_233455. G alpha (i) signalling events.
REACT_263785. Chemokine receptors bind chemokines.

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 20
Alternative name(s):
Beta-chemokine exodus-1
CC chemokine LARC
CC chemokine ST38
Liver and activation-regulated chemokine
Macrophage inflammatory protein 3 alpha
Short name:
MIP-3-alpha
Small-inducible cytokine A20
Gene namesi
Name:Ccl20
Synonyms:Scya20, St38
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 9

Organism-specific databases

RGDi3646. Ccl20.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 26261 PublicationAdd
BLAST
Chaini27 – 9670C-C motif chemokine 20PRO_0000005219Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi31 ↔ 58By similarity
Disulfide bondi32 ↔ 74By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Low levels in thymus and lung.

Inductioni

By TNF in experimental allergic panencaphalomyelitis (EAP) and by TNF and IL-1 in primary astrocytes.

Gene expression databases

GenevestigatoriP97884.

Interactioni

Subunit structurei

Binds to and activate CCR6.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021730.

Structurei

3D structure databases

ProteinModelPortaliP97884.
SMRiP97884. Positions 26-96.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG44269.
GeneTreeiENSGT00530000064223.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiP97884.
KOiK14625.
OMAiAVIFYTK.
OrthoDBiEOG7B31QP.
PhylomeDBiP97884.
TreeFamiTF334888.

Family and domain databases

InterProiIPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P97884-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MACKHLPFLA LAGVLLAYLC SQSEAASNFD CCLTYTKNVY HHARNFVGFT
60 70 80 90
TQMADEACDI NAIIFHLKSK RSVCADPKQI WVKRILHLLS LRTKKM
Length:96
Mass (Da):10,875
Last modified:May 1, 1997 - v1
Checksum:i7B323410F2B2E6DF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U90447 mRNA. Translation: AAB61459.1.
AF053312 mRNA. Translation: AAC78294.1.
RefSeqiNP_062106.1. NM_019233.1.
UniGeneiRn.10722.

Genome annotation databases

EnsembliENSRNOT00000021730; ENSRNOP00000021730; ENSRNOG00000015992.
GeneIDi29538.
KEGGirno:29538.
UCSCiRGD:3646. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U90447 mRNA. Translation: AAB61459.1.
AF053312 mRNA. Translation: AAC78294.1.
RefSeqiNP_062106.1. NM_019233.1.
UniGeneiRn.10722.

3D structure databases

ProteinModelPortaliP97884.
SMRiP97884. Positions 26-96.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021730.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000021730; ENSRNOP00000021730; ENSRNOG00000015992.
GeneIDi29538.
KEGGirno:29538.
UCSCiRGD:3646. rat.

Organism-specific databases

CTDi6364.
RGDi3646. Ccl20.

Phylogenomic databases

eggNOGiNOG44269.
GeneTreeiENSGT00530000064223.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiP97884.
KOiK14625.
OMAiAVIFYTK.
OrthoDBiEOG7B31QP.
PhylomeDBiP97884.
TreeFamiTF334888.

Enzyme and pathway databases

ReactomeiREACT_233455. G alpha (i) signalling events.
REACT_263785. Chemokine receptors bind chemokines.

Miscellaneous databases

NextBioi609527.
PROiP97884.

Gene expression databases

GenevestigatoriP97884.

Family and domain databases

InterProiIPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Activated rat astrocytes produce the CC chemokine Exodus."
    Kelner G.S., Maciejewski-Lenoir D., Lee E.D., Maki R.A.
    Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
  2. "A novel rat CC chemokine, identified by targeted differential display, is upregulated in brain inflammation."
    Utans-Schneitz U., Lorez H., Klinkert W.E.F., da Silva J., Lesslauer W.
    J. Neuroimmunol. 92:179-190(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF N-TERMINUS.
    Strain: Fischer 344.
    Tissue: Brain.

Entry informationi

Entry nameiCCL20_RAT
AccessioniPrimary (citable) accession number: P97884
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: May 1, 1997
Last modified: January 7, 2015
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.