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Protein

C-C motif chemokine 20

Gene

Ccl20

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes (By similarity). May play a role in modulating inflammatory cell recruitment to the CNS and therefore contribute to tissue injury in ischemic stroke and autoimmune diseases.By similarity

GO - Molecular functioni

  • CCR chemokine receptor binding Source: GO_Central
  • chemokine activity Source: RGD

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Enzyme and pathway databases

ReactomeiR-RNO-380108. Chemokine receptors bind chemokines.
R-RNO-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 20
Alternative name(s):
Beta-chemokine exodus-1
CC chemokine LARC
CC chemokine ST38
Liver and activation-regulated chemokine
Macrophage inflammatory protein 3 alpha
Short name:
MIP-3-alpha
Small-inducible cytokine A20
Gene namesi
Name:Ccl20
Synonyms:Scya20, St38
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 9

Organism-specific databases

RGDi3646. Ccl20.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 26261 PublicationAdd
BLAST
Chaini27 – 9670C-C motif chemokine 20PRO_0000005219Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi31 ↔ 58By similarity
Disulfide bondi32 ↔ 74By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP97884.

Expressioni

Tissue specificityi

Low levels in thymus and lung.

Inductioni

By TNF in experimental allergic panencaphalomyelitis (EAP) and by TNF and IL-1 in primary astrocytes.

Gene expression databases

GenevisibleiP97884. RN.

Interactioni

Subunit structurei

Binds to and activate CCR6.By similarity

GO - Molecular functioni

  • CCR chemokine receptor binding Source: GO_Central
  • chemokine activity Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021730.

Structurei

3D structure databases

ProteinModelPortaliP97884.
SMRiP97884. Positions 26-96.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J2BK. Eukaryota.
ENOG410ZGME. LUCA.
GeneTreeiENSGT00530000064223.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiP97884.
KOiK14625.
OMAiAVIFYTK.
OrthoDBiEOG7B31QP.
PhylomeDBiP97884.
TreeFamiTF334888.

Family and domain databases

InterProiIPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P97884-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MACKHLPFLA LAGVLLAYLC SQSEAASNFD CCLTYTKNVY HHARNFVGFT
60 70 80 90
TQMADEACDI NAIIFHLKSK RSVCADPKQI WVKRILHLLS LRTKKM
Length:96
Mass (Da):10,875
Last modified:May 1, 1997 - v1
Checksum:i7B323410F2B2E6DF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U90447 mRNA. Translation: AAB61459.1.
AF053312 mRNA. Translation: AAC78294.1.
RefSeqiNP_062106.1. NM_019233.1.
UniGeneiRn.10722.

Genome annotation databases

EnsembliENSRNOT00000021730; ENSRNOP00000021730; ENSRNOG00000015992.
GeneIDi29538.
KEGGirno:29538.
UCSCiRGD:3646. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U90447 mRNA. Translation: AAB61459.1.
AF053312 mRNA. Translation: AAC78294.1.
RefSeqiNP_062106.1. NM_019233.1.
UniGeneiRn.10722.

3D structure databases

ProteinModelPortaliP97884.
SMRiP97884. Positions 26-96.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021730.

Proteomic databases

PaxDbiP97884.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000021730; ENSRNOP00000021730; ENSRNOG00000015992.
GeneIDi29538.
KEGGirno:29538.
UCSCiRGD:3646. rat.

Organism-specific databases

CTDi6364.
RGDi3646. Ccl20.

Phylogenomic databases

eggNOGiENOG410J2BK. Eukaryota.
ENOG410ZGME. LUCA.
GeneTreeiENSGT00530000064223.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiP97884.
KOiK14625.
OMAiAVIFYTK.
OrthoDBiEOG7B31QP.
PhylomeDBiP97884.
TreeFamiTF334888.

Enzyme and pathway databases

ReactomeiR-RNO-380108. Chemokine receptors bind chemokines.
R-RNO-418594. G alpha (i) signalling events.

Miscellaneous databases

PROiP97884.

Gene expression databases

GenevisibleiP97884. RN.

Family and domain databases

InterProiIPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Activated rat astrocytes produce the CC chemokine Exodus."
    Kelner G.S., Maciejewski-Lenoir D., Lee E.D., Maki R.A.
    Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
  2. "A novel rat CC chemokine, identified by targeted differential display, is upregulated in brain inflammation."
    Utans-Schneitz U., Lorez H., Klinkert W.E.F., da Silva J., Lesslauer W.
    J. Neuroimmunol. 92:179-190(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF N-TERMINUS.
    Strain: Fischer 344.
    Tissue: Brain.

Entry informationi

Entry nameiCCL20_RAT
AccessioniPrimary (citable) accession number: P97884
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: May 1, 1997
Last modified: July 6, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.