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P97884

- CCL20_RAT

UniProt

P97884 - CCL20_RAT

Protein

C-C motif chemokine 20

Gene

Ccl20

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes By similarity. May play a role in modulating inflammatory cell recruitment to the CNS and therefore contribute to tissue injury in ischemic stroke and autoimmune diseases.By similarity

    GO - Molecular functioni

    1. chemokine activity Source: RGD

    GO - Biological processi

    1. cell chemotaxis Source: GOC
    2. cellular response to lipopolysaccharide Source: RGD
    3. cellular response to lipoteichoic acid Source: RGD
    4. cellular response to organic substance Source: RGD
    5. chemotaxis Source: RGD
    6. immune response Source: InterPro
    7. inflammatory response Source: UniProtKB-KW
    8. positive regulation of interleukin-1 alpha biosynthetic process Source: RGD
    9. positive regulation of nitric-oxide synthase biosynthetic process Source: RGD
    10. wound healing Source: RGD

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Chemotaxis, Inflammatory response

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-C motif chemokine 20
    Alternative name(s):
    Beta-chemokine exodus-1
    CC chemokine LARC
    CC chemokine ST38
    Liver and activation-regulated chemokine
    Macrophage inflammatory protein 3 alpha
    Short name:
    MIP-3-alpha
    Small-inducible cytokine A20
    Gene namesi
    Name:Ccl20
    Synonyms:Scya20, St38
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 9

    Organism-specific databases

    RGDi3646. Ccl20.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: RGD

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 26261 PublicationAdd
    BLAST
    Chaini27 – 9670C-C motif chemokine 20PRO_0000005219Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi31 ↔ 58By similarity
    Disulfide bondi32 ↔ 74By similarity

    Keywords - PTMi

    Disulfide bond

    Expressioni

    Tissue specificityi

    Low levels in thymus and lung.

    Inductioni

    By TNF in experimental allergic panencaphalomyelitis (EAP) and by TNF and IL-1 in primary astrocytes.

    Gene expression databases

    GenevestigatoriP97884.

    Interactioni

    Subunit structurei

    Binds to and activate CCR6.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000021730.

    Structurei

    3D structure databases

    ProteinModelPortaliP97884.
    SMRiP97884. Positions 26-96.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG44269.
    GeneTreeiENSGT00530000064223.
    HOGENOMiHOG000036685.
    HOVERGENiHBG017871.
    InParanoidiP97884.
    KOiK14625.
    OMAiYHHARNF.
    OrthoDBiEOG7B31QP.
    PhylomeDBiP97884.
    TreeFamiTF334888.

    Family and domain databases

    InterProiIPR001811. Chemokine_IL8-like_dom.
    [Graphical view]
    PfamiPF00048. IL8. 1 hit.
    [Graphical view]
    SMARTiSM00199. SCY. 1 hit.
    [Graphical view]
    SUPFAMiSSF54117. SSF54117. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P97884-1 [UniParc]FASTAAdd to Basket

    « Hide

    MACKHLPFLA LAGVLLAYLC SQSEAASNFD CCLTYTKNVY HHARNFVGFT   50
    TQMADEACDI NAIIFHLKSK RSVCADPKQI WVKRILHLLS LRTKKM 96
    Length:96
    Mass (Da):10,875
    Last modified:May 1, 1997 - v1
    Checksum:i7B323410F2B2E6DF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U90447 mRNA. Translation: AAB61459.1.
    AF053312 mRNA. Translation: AAC78294.1.
    RefSeqiNP_062106.1. NM_019233.1.
    UniGeneiRn.10722.

    Genome annotation databases

    EnsembliENSRNOT00000021730; ENSRNOP00000021730; ENSRNOG00000015992.
    GeneIDi29538.
    KEGGirno:29538.
    UCSCiRGD:3646. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U90447 mRNA. Translation: AAB61459.1 .
    AF053312 mRNA. Translation: AAC78294.1 .
    RefSeqi NP_062106.1. NM_019233.1.
    UniGenei Rn.10722.

    3D structure databases

    ProteinModelPortali P97884.
    SMRi P97884. Positions 26-96.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000021730.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000021730 ; ENSRNOP00000021730 ; ENSRNOG00000015992 .
    GeneIDi 29538.
    KEGGi rno:29538.
    UCSCi RGD:3646. rat.

    Organism-specific databases

    CTDi 6364.
    RGDi 3646. Ccl20.

    Phylogenomic databases

    eggNOGi NOG44269.
    GeneTreei ENSGT00530000064223.
    HOGENOMi HOG000036685.
    HOVERGENi HBG017871.
    InParanoidi P97884.
    KOi K14625.
    OMAi YHHARNF.
    OrthoDBi EOG7B31QP.
    PhylomeDBi P97884.
    TreeFami TF334888.

    Miscellaneous databases

    NextBioi 609527.
    PROi P97884.

    Gene expression databases

    Genevestigatori P97884.

    Family and domain databases

    InterProi IPR001811. Chemokine_IL8-like_dom.
    [Graphical view ]
    Pfami PF00048. IL8. 1 hit.
    [Graphical view ]
    SMARTi SM00199. SCY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54117. SSF54117. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Activated rat astrocytes produce the CC chemokine Exodus."
      Kelner G.S., Maciejewski-Lenoir D., Lee E.D., Maki R.A.
      Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
    2. "A novel rat CC chemokine, identified by targeted differential display, is upregulated in brain inflammation."
      Utans-Schneitz U., Lorez H., Klinkert W.E.F., da Silva J., Lesslauer W.
      J. Neuroimmunol. 92:179-190(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF N-TERMINUS.
      Strain: Fischer 344.
      Tissue: Brain.

    Entry informationi

    Entry nameiCCL20_RAT
    AccessioniPrimary (citable) accession number: P97884
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: May 1, 1997
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3