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Protein

Exocyst complex component 5

Gene

Exoc5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Exocytosis, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-RNO-264876. Insulin processing.
R-RNO-5620916. VxPx cargo-targeting to cilium.

Names & Taxonomyi

Protein namesi
Recommended name:
Exocyst complex component 5
Alternative name(s):
71 kDa component of rsec6/8 secretory complex
Exocyst complex component Sec10
p71
Gene namesi
Name:Exoc5
Synonyms:Sec10l1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 15

Organism-specific databases

RGDi708408. Exoc5.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: RGD
  • exocyst Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001189452 – 708Exocyst complex component 5Add BLAST707

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei122PhosphothreonineBy similarity1
Modified residuei395PhosphothreonineCombined sources1
Modified residuei405PhosphothreonineCombined sources1
Modified residuei412PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP97878.
PRIDEiP97878.

PTM databases

iPTMnetiP97878.
PhosphoSitePlusiP97878.

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiENSRNOG00000013804.
GenevisibleiP97878. RN.

Interactioni

Subunit structurei

The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8. Interacts with EXOC3L1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000062799.

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili40 – 101Sequence analysisAdd BLAST62

Sequence similaritiesi

Belongs to the SEC10 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3745. Eukaryota.
ENOG410XSQQ. LUCA.
GeneTreeiENSGT00390000012837.
HOGENOMiHOG000007911.
HOVERGENiHBG055591.
InParanoidiP97878.
KOiK19984.
OMAiMCAICDV.
OrthoDBiEOG091G03RW.

Family and domain databases

InterProiIPR033960. EXOC5/Sec10.
IPR009976. Sec10-like.
[Graphical view]
PANTHERiPTHR12100. PTHR12100. 1 hit.
PTHR12100:SF0. PTHR12100:SF0. 1 hit.
PfamiPF07393. Sec10. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P97878-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATTAELFEE PFVADEYIER LVWRTPGGGS RGGPEAFDPK RLLEEFVNHI
60 70 80 90 100
QELQIMDERI QRKVEKLEQQ CQKEAKEFAK KVQELQKSNQ VAFQHFQELD
110 120 130 140 150
EHISYVATKV CHLGDQLEGV NTPRQRAVEA QKLMKYFNEF LDGELKSDVF
160 170 180 190 200
TNPEKIKEAA DVIQKLHLIA QELPFDRFSE VKSKIASKYH DLECQLIQEF
210 220 230 240 250
TSAQRRGEVS RMREVAAVLL HFKGYSHCID VYIKQCQEGA YLRNDIFEDA
260 270 280 290 300
AILCQRVNKQ VGDIFSNPEA VLAKLIQNVF EVKLQSFVKD QLEECRKSDA
310 320 330 340 350
EQYLKSLYDL YTRTTSLSSK LMEFNLGTDK QTFLSKLIKS IFVSYLENYI
360 370 380 390 400
EVEIGYLKSR SAMILQRYYD SKNHQKRSIG TGGIQDLKER IRQRTNLPLG
410 420 430 440 450
PSIDTHGETF LSQEVVVNLL QETKQAFERC HRLSDPSDLP RNAFRIFTIL
460 470 480 490 500
VEFLCIEHID YALETGLAGI PSSDSRNANL YFLDVVQQAN TIFHLFDKQF
510 520 530 540 550
NDHLMPLISS SPKLSECLQK KKEIIEQMEM KLDTGIDRTL NCMIGQMKHI
560 570 580 590 600
LAAEQKKTDF KPEDENNVLI QYTNACVKVC AYVRKQVEKI KNSMDGKNVD
610 620 630 640 650
TVLMELGVRF HRLTYEHLQQ YSYSCMGGML AICDVAEYRK CAKDFKIPMV
660 670 680 690 700
LHLFDTLHAL CNLLVVAPDN LKQVCSGEQL ANLDKNILHS FVQLRADYRS

ARLARHFS
Length:708
Mass (Da):81,737
Last modified:May 1, 1997 - v1
Checksum:i567BEE0E5E43EF59
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U79417 mRNA. Translation: AAC53096.1.
BC128739 mRNA. Translation: AAI28740.1.
PIRiJC6329.
RefSeqiNP_071540.1. NM_022204.3.
UniGeneiRn.44430.

Genome annotation databases

EnsembliENSRNOT00000067735; ENSRNOP00000062799; ENSRNOG00000013804.
GeneIDi60627.
KEGGirno:60627.
UCSCiRGD:708408. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U79417 mRNA. Translation: AAC53096.1.
BC128739 mRNA. Translation: AAI28740.1.
PIRiJC6329.
RefSeqiNP_071540.1. NM_022204.3.
UniGeneiRn.44430.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000062799.

PTM databases

iPTMnetiP97878.
PhosphoSitePlusiP97878.

Proteomic databases

PaxDbiP97878.
PRIDEiP97878.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000067735; ENSRNOP00000062799; ENSRNOG00000013804.
GeneIDi60627.
KEGGirno:60627.
UCSCiRGD:708408. rat.

Organism-specific databases

CTDi10640.
RGDi708408. Exoc5.

Phylogenomic databases

eggNOGiKOG3745. Eukaryota.
ENOG410XSQQ. LUCA.
GeneTreeiENSGT00390000012837.
HOGENOMiHOG000007911.
HOVERGENiHBG055591.
InParanoidiP97878.
KOiK19984.
OMAiMCAICDV.
OrthoDBiEOG091G03RW.

Enzyme and pathway databases

ReactomeiR-RNO-264876. Insulin processing.
R-RNO-5620916. VxPx cargo-targeting to cilium.

Miscellaneous databases

PROiP97878.

Gene expression databases

BgeeiENSRNOG00000013804.
GenevisibleiP97878. RN.

Family and domain databases

InterProiIPR033960. EXOC5/Sec10.
IPR009976. Sec10-like.
[Graphical view]
PANTHERiPTHR12100. PTHR12100. 1 hit.
PTHR12100:SF0. PTHR12100:SF0. 1 hit.
PfamiPF07393. Sec10. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEXOC5_RAT
AccessioniPrimary (citable) accession number: P97878
Secondary accession number(s): A1A5N5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: May 1, 1997
Last modified: November 30, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.