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Protein

Basic leucine zipper transcriptional factor ATF-like 3

Gene

Batf3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

AP-1 family transcription factor that controls the differentiation of CD8+ thymic conventional dendritic cells in the immune system. Acts via the formation of a heterodimer with JUN family proteins that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3' and regulates expression of target genes. Required for development of CD8-alpha+ classical dendritic cells (cDCs) and related CD103+ dendritic cells that cross-present antigens to CD8 T-cells and produce interleukin-12 (IL12) in response to pathogens (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Basic leucine zipper transcriptional factor ATF-like 3
Short name:
B-ATF-3
Alternative name(s):
Jun dimerization protein 1
Short name:
JDP-1
Gene namesi
Name:Batf3
Synonyms:Jdp1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620501. Batf3.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 133133Basic leucine zipper transcriptional factor ATF-like 3PRO_0000326108Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21PhosphoserineBy similarity
Modified residuei24 – 241PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP97876.

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Interactioni

Subunit structurei

Heterodimer; heterodimerizes with JUN family proteins. Interacts with JUN.1 Publication

GO - Molecular functioni

  • protein heterodimerization activity Source: RGD

Protein-protein interaction databases

BioGridi248847. 1 interaction.
STRINGi10116.ENSRNOP00000004962.

Structurei

3D structure databases

ProteinModelPortaliP97876.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 9164bZIPPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni30 – 5526Basic motifPROSITE-ProRule annotationAdd
BLAST
Regioni56 – 8429Leucine-zipperPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the bZIP family.Curated
Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1414. Eukaryota.
ENOG4111CH5. LUCA.
HOGENOMiHOG000236325.
HOVERGENiHBG096186.
InParanoidiP97876.
KOiK09034.
PhylomeDBiP97876.

Family and domain databases

InterProiIPR000837. AP-1.
IPR004827. bZIP.
IPR029818. p21SNFT.
[Graphical view]
PANTHERiPTHR23351. PTHR23351. 1 hit.
PTHR23351:SF13. PTHR23351:SF13. 1 hit.
PfamiPF07716. bZIP_2. 1 hit.
[Graphical view]
PRINTSiPR00042. LEUZIPPRFOS.
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P97876-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQGPPAGGV LQSSVAAPGN QPQSPKDDDR KVRRREKNRV AAQRSRKKQT
60 70 80 90 100
QKSDKLHEEH ESLEQENSVL RREIAKLKEE LRHLTEALKE HEKMCPLLLC
110 120 130
PMNFVQLRPD PVASWSAHDA PDHPSFIWLG TLV
Length:133
Mass (Da):15,129
Last modified:May 1, 1997 - v1
Checksum:i0A38C37121EB06F2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U53450 Genomic DNA. Translation: AAB49921.1.
RefSeqiNP_068637.1. NM_021865.1.
UniGeneiRn.211982.

Genome annotation databases

GeneIDi60462.
KEGGirno:60462.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U53450 Genomic DNA. Translation: AAB49921.1.
RefSeqiNP_068637.1. NM_021865.1.
UniGeneiRn.211982.

3D structure databases

ProteinModelPortaliP97876.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi248847. 1 interaction.
STRINGi10116.ENSRNOP00000004962.

Proteomic databases

PaxDbiP97876.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi60462.
KEGGirno:60462.

Organism-specific databases

CTDi55509.
RGDi620501. Batf3.

Phylogenomic databases

eggNOGiKOG1414. Eukaryota.
ENOG4111CH5. LUCA.
HOGENOMiHOG000236325.
HOVERGENiHBG096186.
InParanoidiP97876.
KOiK09034.
PhylomeDBiP97876.

Miscellaneous databases

PROiP97876.

Family and domain databases

InterProiIPR000837. AP-1.
IPR004827. bZIP.
IPR029818. p21SNFT.
[Graphical view]
PANTHERiPTHR23351. PTHR23351. 1 hit.
PTHR23351:SF13. PTHR23351:SF13. 1 hit.
PfamiPF07716. bZIP_2. 1 hit.
[Graphical view]
PRINTSiPR00042. LEUZIPPRFOS.
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Isolation of an AP-1 repressor by a novel method for detecting protein-protein interactions."
    Aronheim A., Zandi E., Hennemann H., Elledge S.J., Karin M.
    Mol. Cell. Biol. 17:3094-3102(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY, INTERACTION WITH JUN.

Entry informationi

Entry nameiBATF3_RAT
AccessioniPrimary (citable) accession number: P97876
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: May 1, 1997
Last modified: July 6, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.