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Protein

Basic leucine zipper transcriptional factor ATF-like 3

Gene

Batf3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

AP-1 family transcription factor that controls the differentiation of CD8+ thymic conventional dendritic cells in the immune system. Acts via the formation of a heterodimer with JUN family proteins that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3' and regulates expression of target genes. Required for development of CD8-alpha+ classical dendritic cells (cDCs) and related CD103+ dendritic cells that cross-present antigens to CD8 T-cells and produce interleukin-12 (IL12) in response to pathogens (By similarity).By similarity

GO - Molecular functioni

  • DNA binding Source: RGD
  • protein heterodimerization activity Source: RGD
  • sequence-specific DNA binding Source: InterPro
  • transcription factor activity, sequence-specific DNA binding Source: InterPro

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding, Repressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Basic leucine zipper transcriptional factor ATF-like 3
Short name:
B-ATF-3
Alternative name(s):
Jun dimerization protein 1
Short name:
JDP-1
Gene namesi
Name:Batf3
Synonyms:Jdp1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620501. Batf3.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003261081 – 133Basic leucine zipper transcriptional factor ATF-like 3Add BLAST133

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2PhosphoserineBy similarity1
Modified residuei24PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP97876.

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Interactioni

Subunit structurei

Heterodimer; heterodimerizes with JUN family proteins. Interacts with JUN.1 Publication

GO - Molecular functioni

  • protein heterodimerization activity Source: RGD

Protein-protein interaction databases

BioGridi248847. 1 interactor.
STRINGi10116.ENSRNOP00000004962.

Structurei

3D structure databases

ProteinModelPortaliP97876.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 91bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni30 – 55Basic motifPROSITE-ProRule annotationAdd BLAST26
Regioni56 – 84Leucine-zipperPROSITE-ProRule annotationAdd BLAST29

Sequence similaritiesi

Belongs to the bZIP family.Curated

Phylogenomic databases

eggNOGiKOG1414. Eukaryota.
ENOG4111CH5. LUCA.
HOGENOMiHOG000236325.
HOVERGENiHBG096186.
InParanoidiP97876.
KOiK09034.
PhylomeDBiP97876.

Family and domain databases

InterProiView protein in InterPro
IPR000837. AP-1.
IPR004827. bZIP.
IPR029818. p21SNFT.
PANTHERiPTHR23351. PTHR23351. 1 hit.
PTHR23351:SF33. PTHR23351:SF33. 1 hit.
PfamiView protein in Pfam
PF07716. bZIP_2. 1 hit.
PRINTSiPR00042. LEUZIPPRFOS.
SMARTiView protein in SMART
SM00338. BRLZ. 1 hit.
PROSITEiView protein in PROSITE
PS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.

Sequencei

Sequence statusi: Complete.

P97876-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQGPPAGGV LQSSVAAPGN QPQSPKDDDR KVRRREKNRV AAQRSRKKQT
60 70 80 90 100
QKSDKLHEEH ESLEQENSVL RREIAKLKEE LRHLTEALKE HEKMCPLLLC
110 120 130
PMNFVQLRPD PVASWSAHDA PDHPSFIWLG TLV
Length:133
Mass (Da):15,129
Last modified:May 1, 1997 - v1
Checksum:i0A38C37121EB06F2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U53450 Genomic DNA. Translation: AAB49921.1.
RefSeqiNP_068637.1. NM_021865.1.
UniGeneiRn.211982.

Genome annotation databases

GeneIDi60462.
KEGGirno:60462.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U53450 Genomic DNA. Translation: AAB49921.1.
RefSeqiNP_068637.1. NM_021865.1.
UniGeneiRn.211982.

3D structure databases

ProteinModelPortaliP97876.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi248847. 1 interactor.
STRINGi10116.ENSRNOP00000004962.

Proteomic databases

PaxDbiP97876.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi60462.
KEGGirno:60462.

Organism-specific databases

CTDi55509.
RGDi620501. Batf3.

Phylogenomic databases

eggNOGiKOG1414. Eukaryota.
ENOG4111CH5. LUCA.
HOGENOMiHOG000236325.
HOVERGENiHBG096186.
InParanoidiP97876.
KOiK09034.
PhylomeDBiP97876.

Miscellaneous databases

PROiPR:P97876.

Family and domain databases

InterProiView protein in InterPro
IPR000837. AP-1.
IPR004827. bZIP.
IPR029818. p21SNFT.
PANTHERiPTHR23351. PTHR23351. 1 hit.
PTHR23351:SF33. PTHR23351:SF33. 1 hit.
PfamiView protein in Pfam
PF07716. bZIP_2. 1 hit.
PRINTSiPR00042. LEUZIPPRFOS.
SMARTiView protein in SMART
SM00338. BRLZ. 1 hit.
PROSITEiView protein in PROSITE
PS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiBATF3_RAT
AccessioniPrimary (citable) accession number: P97876
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: May 1, 1997
Last modified: March 15, 2017
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.