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P97875

- JDP2_MOUSE

UniProt

P97875 - JDP2_MOUSE

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Protein

Jun dimerization protein 2

Gene

Jdp2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Component of the AP-1 transcription factor that represses transactivation mediated by the Jun family of proteins. Involved in a variety of transcriptional responses associated with AP-1, such as UV-induced apoptosis, cell differentiation, tumorigenesis and antitumogeneris. Can also function as a repressor by recruiting histone deacetylase 3/HDAC3 to the promoter region of JUN. May control transcription via direct regulation of the modification of histones and the assembly of chromatin (By similarity).By similarity

GO - Molecular functioni

  1. chromatin binding Source: MGI
  2. DNA binding Source: MGI
  3. double-stranded DNA binding Source: Ensembl
  4. sequence-specific DNA binding Source: InterPro
  5. sequence-specific DNA binding transcription factor activity Source: Ensembl

GO - Biological processi

  1. negative regulation of fat cell differentiation Source: MGI
  2. negative regulation of transcription from RNA polymerase II promoter Source: MGI
  3. positive regulation of histone deacetylation Source: MGI
  4. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Jun dimerization protein 2
Gene namesi
Name:Jdp2
Synonyms:Jundm2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 12

Organism-specific databases

MGIiMGI:1932093. Jdp2.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi148 – 1481T → A: Blocks phosphorylation by MAPK8. 2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 163163Jun dimerization protein 2PRO_0000331131Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei148 – 1481Phosphothreonine; by MAPK82 Publications

Post-translational modificationi

Phosphorylation of Thr-148 by MAPK8 in response to different stress conditions such as, UV irradiation, oxidatives stress and anisomycin treatments.2 Publications
Polyubiquitinated; probably by IRF2BP1.By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP97875.
PRIDEiP97875.

PTM databases

PhosphoSiteiP97875.

Expressioni

Tissue specificityi

Ubiquitously expressed in all adult tissues tested as well in embryos.1 Publication

Gene expression databases

BgeeiP97875.
ExpressionAtlasiP97875. baseline and differential.
GenevestigatoriP97875.

Interactioni

Subunit structurei

Forms a homodimer or heterodimer with JUN, JUNB, JUND, CEBPG and ATF2 thereby inhibiting transactivation by JUN, ATF2 and CEBPG (By similarity). Binds multiple DNA elements such as cAMP-response element (CRE) and TPA response element (TRE) either as homodimer or heterodimer. Interacts with IRF2BP1 (By similarity).By similarity

Protein-protein interaction databases

BioGridi219888. 14 interactions.
STRINGi10090.ENSMUSP00000059724.

Structurei

3D structure databases

ProteinModelPortaliP97875.
SMRiP97875. Positions 73-135.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini72 – 13564bZIPPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni74 – 9623Basic motifPROSITE-ProRule annotationAdd
BLAST
Regioni100 – 12829Leucine-zipperPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the bZIP family. ATF subfamily.Curated
Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG280450.
GeneTreeiENSGT00730000110847.
HOGENOMiHOG000034126.
HOVERGENiHBG057870.
InParanoidiP97875.
KOiK09033.
OMAiPLQFLEV.
OrthoDBiEOG70S777.
PhylomeDBiP97875.
TreeFamiTF326301.

Family and domain databases

InterProiIPR000837. AP-1.
IPR004827. bZIP.
[Graphical view]
PfamiPF00170. bZIP_1. 1 hit.
[Graphical view]
PRINTSiPR00042. LEUZIPPRFOS.
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P97875 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MMPGQIPDPS VTAGSLPGLG PLTGLPSSAL TTEELKYADI RNIGAMIAPL
60 70 80 90 100
HFLEVKLGKR PQPVKSELDE EEERRKRRRE KNKVAAARCR NKKKERTEFL
110 120 130 140 150
QRESERLELM NAELKTQIEE LKLERQQLIL MLNRHRPTCI VRTDSVRTPE
160
SEGNPLLEQL DKK
Length:163
Mass (Da):18,675
Last modified:June 1, 1998 - v2
Checksum:iA8AB65A7D20564F8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB077438 mRNA. Translation: BAB83764.1.
BC019780 mRNA. Translation: AAH19780.1.
CCDSiCCDS26060.1.
RefSeqiNP_001191981.1. NM_001205052.1.
NP_001191982.1. NM_001205053.1.
NP_112149.2. NM_030887.2.
UniGeneiMm.103560.

Genome annotation databases

EnsembliENSMUST00000050687; ENSMUSP00000059724; ENSMUSG00000034271.
ENSMUST00000171754; ENSMUSP00000129985; ENSMUSG00000034271.
ENSMUST00000177587; ENSMUSP00000136823; ENSMUSG00000034271.
GeneIDi81703.
KEGGimmu:81703.
UCSCiuc007ohb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB077438 mRNA. Translation: BAB83764.1 .
BC019780 mRNA. Translation: AAH19780.1 .
CCDSi CCDS26060.1.
RefSeqi NP_001191981.1. NM_001205052.1.
NP_001191982.1. NM_001205053.1.
NP_112149.2. NM_030887.2.
UniGenei Mm.103560.

3D structure databases

ProteinModelPortali P97875.
SMRi P97875. Positions 73-135.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 219888. 14 interactions.
STRINGi 10090.ENSMUSP00000059724.

PTM databases

PhosphoSitei P97875.

Proteomic databases

MaxQBi P97875.
PRIDEi P97875.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000050687 ; ENSMUSP00000059724 ; ENSMUSG00000034271 .
ENSMUST00000171754 ; ENSMUSP00000129985 ; ENSMUSG00000034271 .
ENSMUST00000177587 ; ENSMUSP00000136823 ; ENSMUSG00000034271 .
GeneIDi 81703.
KEGGi mmu:81703.
UCSCi uc007ohb.1. mouse.

Organism-specific databases

CTDi 122953.
MGIi MGI:1932093. Jdp2.

Phylogenomic databases

eggNOGi NOG280450.
GeneTreei ENSGT00730000110847.
HOGENOMi HOG000034126.
HOVERGENi HBG057870.
InParanoidi P97875.
KOi K09033.
OMAi PLQFLEV.
OrthoDBi EOG70S777.
PhylomeDBi P97875.
TreeFami TF326301.

Miscellaneous databases

NextBioi 350432.
PROi P97875.
SOURCEi Search...

Gene expression databases

Bgeei P97875.
ExpressionAtlasi P97875. baseline and differential.
Genevestigatori P97875.

Family and domain databases

InterProi IPR000837. AP-1.
IPR004827. bZIP.
[Graphical view ]
Pfami PF00170. bZIP_1. 1 hit.
[Graphical view ]
PRINTSi PR00042. LEUZIPPRFOS.
SMARTi SM00338. BRLZ. 1 hit.
[Graphical view ]
PROSITEi PS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Jun dimerization protein 2 (JDP2), a member of the AP-1 family of transcription factor, mediates osteoclast differentiation induced by RANKL."
    Kawaida R., Ohtsuka T., Okutsu J., Takahashi T., Kadono Y., Oda H., Hikita A., Nakamura K., Tanaka S., Furukawa H.
    J. Exp. Med. 197:1029-1035(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Czech II.
    Tissue: Mammary tumor.
  3. "Identification of mouse Jun dimerization protein 2 as a novel repressor of ATF-2."
    Jin C., Ugai H., Song J., Murata T., Nili F., Sun K., Horikoshi M., Yokoyama K.K.
    FEBS Lett. 489:34-41(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, INTERACTION WITH ATF2, DNA-BINDING.
  4. "The AP-1 repressor, JDP2, is a bona fide substrate for the c-Jun N-terminal kinase."
    Katz S., Heinrich R., Aronheim A.
    FEBS Lett. 506:196-200(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ATF2, PHOSPHORYLATION AT THR-148 BY MAPK8, MUTAGENESIS OF THR-148.
  5. "The c-Jun dimerization protein 2 inhibits cell transformation and acts as a tumor suppressor gene."
    Heinrich R., Livne E., Ben-Izhak O., Aronheim A.
    J. Biol. Chem. 279:5708-5715(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  6. "Phosphorylation of two eukaryotic transcription factors, Jun dimerization protein 2 and activation transcription factor 2, in Escherichia coli by Jun N-terminal kinase 1."
    Murata T., Shinozuka Y., Obata Y., Yokoyama K.K.
    Anal. Biochem. 376:115-121(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ATF2, PHOSPHORYLATION AT THR-148 BY MAPK8/JNK1, MUTAGENESIS OF THR-148.

Entry informationi

Entry nameiJDP2_MOUSE
AccessioniPrimary (citable) accession number: P97875
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: June 1, 1998
Last modified: October 29, 2014
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3