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P97875

- JDP2_MOUSE

UniProt

P97875 - JDP2_MOUSE

Protein

Jun dimerization protein 2

Gene

Jdp2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Component of the AP-1 transcription factor that represses transactivation mediated by the Jun family of proteins. Involved in a variety of transcriptional responses associated with AP-1, such as UV-induced apoptosis, cell differentiation, tumorigenesis and antitumogeneris. Can also function as a repressor by recruiting histone deacetylase 3/HDAC3 to the promoter region of JUN. May control transcription via direct regulation of the modification of histones and the assembly of chromatin By similarity.By similarity

    GO - Molecular functioni

    1. chromatin binding Source: MGI
    2. DNA binding Source: MGI
    3. double-stranded DNA binding Source: Ensembl
    4. protein binding Source: MGI
    5. sequence-specific DNA binding Source: InterPro
    6. sequence-specific DNA binding transcription factor activity Source: Ensembl

    GO - Biological processi

    1. negative regulation of fat cell differentiation Source: MGI
    2. negative regulation of transcription from RNA polymerase II promoter Source: MGI
    3. positive regulation of histone deacetylation Source: MGI
    4. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Jun dimerization protein 2
    Gene namesi
    Name:Jdp2
    Synonyms:Jundm2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 12

    Organism-specific databases

    MGIiMGI:1932093. Jdp2.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: MGI

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi148 – 1481T → A: Blocks phosphorylation by MAPK8. 2 Publications

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 163163Jun dimerization protein 2PRO_0000331131Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei148 – 1481Phosphothreonine; by MAPK82 Publications

    Post-translational modificationi

    Phosphorylation of Thr-148 by MAPK8 in response to different stress conditions such as, UV irradiation, oxidatives stress and anisomycin treatments.2 Publications
    Polyubiquitinated; probably by IRF2BP1.By similarity

    Keywords - PTMi

    Phosphoprotein, Ubl conjugation

    Proteomic databases

    MaxQBiP97875.
    PRIDEiP97875.

    PTM databases

    PhosphoSiteiP97875.

    Expressioni

    Tissue specificityi

    Ubiquitously expressed in all adult tissues tested as well in embryos.1 Publication

    Gene expression databases

    ArrayExpressiP97875.
    BgeeiP97875.
    GenevestigatoriP97875.

    Interactioni

    Subunit structurei

    Forms a homodimer or heterodimer with JUN, JUNB, JUND, CEBPG and ATF2 thereby inhibiting transactivation by JUN, ATF2 and CEBPG By similarity. Binds multiple DNA elements such as cAMP-response element (CRE) and TPA response element (TRE) either as homodimer or heterodimer. Interacts with IRF2BP1 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi219888. 14 interactions.
    STRINGi10090.ENSMUSP00000059724.

    Structurei

    3D structure databases

    ProteinModelPortaliP97875.
    SMRiP97875. Positions 73-135.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini72 – 13564bZIPPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni74 – 9623Basic motifPROSITE-ProRule annotationAdd
    BLAST
    Regioni100 – 12829Leucine-zipperPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the bZIP family. ATF subfamily.Curated
    Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG280450.
    GeneTreeiENSGT00730000110847.
    HOGENOMiHOG000034126.
    HOVERGENiHBG057870.
    InParanoidiP97875.
    KOiK09033.
    OMAiPLQFLEV.
    OrthoDBiEOG70S777.
    PhylomeDBiP97875.
    TreeFamiTF326301.

    Family and domain databases

    InterProiIPR004827. bZIP.
    IPR000837. Leuzip_Fos.
    [Graphical view]
    PfamiPF00170. bZIP_1. 1 hit.
    [Graphical view]
    PRINTSiPR00042. LEUZIPPRFOS.
    SMARTiSM00338. BRLZ. 1 hit.
    [Graphical view]
    PROSITEiPS50217. BZIP. 1 hit.
    PS00036. BZIP_BASIC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P97875-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMPGQIPDPS VTAGSLPGLG PLTGLPSSAL TTEELKYADI RNIGAMIAPL    50
    HFLEVKLGKR PQPVKSELDE EEERRKRRRE KNKVAAARCR NKKKERTEFL 100
    QRESERLELM NAELKTQIEE LKLERQQLIL MLNRHRPTCI VRTDSVRTPE 150
    SEGNPLLEQL DKK 163
    Length:163
    Mass (Da):18,675
    Last modified:June 1, 1998 - v2
    Checksum:iA8AB65A7D20564F8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB077438 mRNA. Translation: BAB83764.1.
    BC019780 mRNA. Translation: AAH19780.1.
    CCDSiCCDS26060.1.
    RefSeqiNP_001191981.1. NM_001205052.1.
    NP_001191982.1. NM_001205053.1.
    NP_112149.2. NM_030887.2.
    UniGeneiMm.103560.

    Genome annotation databases

    EnsembliENSMUST00000050687; ENSMUSP00000059724; ENSMUSG00000034271.
    ENSMUST00000171754; ENSMUSP00000129985; ENSMUSG00000034271.
    ENSMUST00000177587; ENSMUSP00000136823; ENSMUSG00000034271.
    GeneIDi81703.
    KEGGimmu:81703.
    UCSCiuc007ohb.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB077438 mRNA. Translation: BAB83764.1 .
    BC019780 mRNA. Translation: AAH19780.1 .
    CCDSi CCDS26060.1.
    RefSeqi NP_001191981.1. NM_001205052.1.
    NP_001191982.1. NM_001205053.1.
    NP_112149.2. NM_030887.2.
    UniGenei Mm.103560.

    3D structure databases

    ProteinModelPortali P97875.
    SMRi P97875. Positions 73-135.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 219888. 14 interactions.
    STRINGi 10090.ENSMUSP00000059724.

    PTM databases

    PhosphoSitei P97875.

    Proteomic databases

    MaxQBi P97875.
    PRIDEi P97875.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000050687 ; ENSMUSP00000059724 ; ENSMUSG00000034271 .
    ENSMUST00000171754 ; ENSMUSP00000129985 ; ENSMUSG00000034271 .
    ENSMUST00000177587 ; ENSMUSP00000136823 ; ENSMUSG00000034271 .
    GeneIDi 81703.
    KEGGi mmu:81703.
    UCSCi uc007ohb.1. mouse.

    Organism-specific databases

    CTDi 122953.
    MGIi MGI:1932093. Jdp2.

    Phylogenomic databases

    eggNOGi NOG280450.
    GeneTreei ENSGT00730000110847.
    HOGENOMi HOG000034126.
    HOVERGENi HBG057870.
    InParanoidi P97875.
    KOi K09033.
    OMAi PLQFLEV.
    OrthoDBi EOG70S777.
    PhylomeDBi P97875.
    TreeFami TF326301.

    Miscellaneous databases

    NextBioi 350432.
    PROi P97875.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P97875.
    Bgeei P97875.
    Genevestigatori P97875.

    Family and domain databases

    InterProi IPR004827. bZIP.
    IPR000837. Leuzip_Fos.
    [Graphical view ]
    Pfami PF00170. bZIP_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00042. LEUZIPPRFOS.
    SMARTi SM00338. BRLZ. 1 hit.
    [Graphical view ]
    PROSITEi PS50217. BZIP. 1 hit.
    PS00036. BZIP_BASIC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Jun dimerization protein 2 (JDP2), a member of the AP-1 family of transcription factor, mediates osteoclast differentiation induced by RANKL."
      Kawaida R., Ohtsuka T., Okutsu J., Takahashi T., Kadono Y., Oda H., Hikita A., Nakamura K., Tanaka S., Furukawa H.
      J. Exp. Med. 197:1029-1035(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Czech II.
      Tissue: Mammary tumor.
    3. "Identification of mouse Jun dimerization protein 2 as a novel repressor of ATF-2."
      Jin C., Ugai H., Song J., Murata T., Nili F., Sun K., Horikoshi M., Yokoyama K.K.
      FEBS Lett. 489:34-41(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, INTERACTION WITH ATF2, DNA-BINDING.
    4. "The AP-1 repressor, JDP2, is a bona fide substrate for the c-Jun N-terminal kinase."
      Katz S., Heinrich R., Aronheim A.
      FEBS Lett. 506:196-200(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ATF2, PHOSPHORYLATION AT THR-148 BY MAPK8, MUTAGENESIS OF THR-148.
    5. "The c-Jun dimerization protein 2 inhibits cell transformation and acts as a tumor suppressor gene."
      Heinrich R., Livne E., Ben-Izhak O., Aronheim A.
      J. Biol. Chem. 279:5708-5715(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    6. "Phosphorylation of two eukaryotic transcription factors, Jun dimerization protein 2 and activation transcription factor 2, in Escherichia coli by Jun N-terminal kinase 1."
      Murata T., Shinozuka Y., Obata Y., Yokoyama K.K.
      Anal. Biochem. 376:115-121(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ATF2, PHOSPHORYLATION AT THR-148 BY MAPK8/JNK1, MUTAGENESIS OF THR-148.

    Entry informationi

    Entry nameiJDP2_MOUSE
    AccessioniPrimary (citable) accession number: P97875
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 29, 2008
    Last sequence update: June 1, 1998
    Last modified: October 1, 2014
    This is version 111 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3