Jun dimerization protein 2 - Mus musculus (Mouse)

Contribute

Send feedback

Read comments (?) or add your own

P97875 (JDP2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 98. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

text xml rdf/xml gff fasta

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Jun dimerization protein 2

Gene names

Name:	Jdp2
Synonyms:	Jundm2

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	163 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Component of the AP-1 transcription factor that represses transactivation mediated by the Jun family of proteins. Involved in a variety of transcriptional responses associated with AP-1, such as UV-induced apoptosis, cell differentiation, tumorigenesis and antitumogeneris. Can also function as a repressor by recruiting histone deacetylase 3/HDAC3 to the promoter region of JUN. May control transcription via direct regulation of the modification of histones and the assembly of chromatin By similarity. Ref.1 Ref.5
Subunit structure	Forms a homodimer or heterodimer with JUN, JUNB, JUND, CEBPG and ATF2 thereby inhibiting transactivation by JUN, ATF2 and CEBPG By similarity. Binds multiple DNA elements such as cAMP-response element (CRE) and TPA response element (TRE) either as homodimer or heterodimer. Interacts with IRF2BP1 By similarity. Ref.3 Ref.4 Ref.6
Subcellular location	Nucleus Probable.
Tissue specificity	Ubiquitously expressed in all adult tissues tested as well in embryos. Ref.3
Post-translational modification	Phosphorylation of Thr-148 by MAPK8 in response to different stress conditions such as, UV irradiation, oxidatives stress and anisomycin treatments. Polyubiquitinated; probably by IRF2BP1 By similarity.
Sequence similarities	Belongs to the bZIP family. ATF subfamily. Contains 1 bZIP (basic-leucine zipper) domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Ligand	DNA-binding
Molecular function	Repressor
PTM	Phosphoprotein Ubl conjugation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	negative regulation of fat cell differentiation Inferred from direct assay PubMed 17464331. Source: MGI negative regulation of transcription from RNA polymerase II promoter Inferred from direct assay Ref.3. Source: MGI positive regulation of histone deacetylation Inferred from genetic interaction PubMed 17464331. Source: MGI transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from direct assay PubMed 17464331. Source: MGI
Molecular_function	DNA binding Inferred from direct assay Ref.3. Source: MGI chromatin binding Inferred from direct assay PubMed 17464331. Source: MGI double-stranded DNA binding Inferred from electronic annotation. Source: Compara sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 163

163

Jun dimerization protein 2

PRO_0000331131

Regions

Domain

72 – 135

bZIP

Region

74 – 96

Basic motif By similarity

Region

100 – 128

Leucine-zipper By similarity

Amino acid modifications

Modified residue

148

Phosphothreonine; by MAPK8 Ref.4 Ref.6

Experimental info

Mutagenesis

148

T → A: Blocks phosphorylation by MAPK8. Ref.4 Ref.6

Sequences

Sequence

Length

Mass (Da)

Tools

P97875 [UniParc].

Last modified June 1, 1998. Version 2.
Checksum: A8AB65A7D20564F8
Show »

FASTA

163

18,675

        10         20         30         40         50         60 
MMPGQIPDPS VTAGSLPGLG PLTGLPSSAL TTEELKYADI RNIGAMIAPL HFLEVKLGKR 

        70         80         90        100        110        120 
PQPVKSELDE EEERRKRRRE KNKVAAARCR NKKKERTEFL QRESERLELM NAELKTQIEE 

       130        140        150        160 
LKLERQQLIL MLNRHRPTCI VRTDSVRTPE SEGNPLLEQL DKK

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Jun dimerization protein 2 (JDP2), a member of the AP-1 family of transcription factor, mediates osteoclast differentiation induced by RANKL." Kawaida R., Ohtsuka T., Okutsu J., Takahashi T., Kadono Y., Oda H., Hikita A., Nakamura K., Tanaka S., Furukawa H. J. Exp. Med. 197:1029-1035(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Czech II. Tissue: Mammary tumor.
[3]	"Identification of mouse Jun dimerization protein 2 as a novel repressor of ATF-2." Jin C., Ugai H., Song J., Murata T., Nili F., Sun K., Horikoshi M., Yokoyama K.K. FEBS Lett. 489:34-41(2001) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY, INTERACTION WITH ATF2, DNA-BINDING.
[4]	"The AP-1 repressor, JDP2, is a bona fide substrate for the c-Jun N-terminal kinase." Katz S., Heinrich R., Aronheim A. FEBS Lett. 506:196-200(2001) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH ATF2, PHOSPHORYLATION AT THR-148 BY MAPK8, MUTAGENESIS OF THR-148.
[5]	"The c-Jun dimerization protein 2 inhibits cell transformation and acts as a tumor suppressor gene." Heinrich R., Livne E., Ben-Izhak O., Aronheim A. J. Biol. Chem. 279:5708-5715(2004) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[6]	"Phosphorylation of two eukaryotic transcription factors, Jun dimerization protein 2 and activation transcription factor 2, in Escherichia coli by Jun N-terminal kinase 1." Murata T., Shinozuka Y., Obata Y., Yokoyama K.K. Anal. Biochem. 376:115-121(2008) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH ATF2, PHOSPHORYLATION AT THR-148 BY MAPK8/JNK1, MUTAGENESIS OF THR-148.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB077438 mRNA. Translation: BAB83764.1. BC019780 mRNA. Translation: AAH19780.1.
IPI	IPI00331298.
RefSeq	NP_001191981.1. NM_001205052.1. NP_001191982.1. NM_001205053.1. NP_112149.2. NM_030887.2.
UniGene	Mm.103560.
3D structure databases
HSSP	HSSP built from PDB template 1S9K based on UniProtKB P01100.
ProteinModelPortal	P97875.
SMR	P97875. Positions 73-135.
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000059724.
PTM databases
PhosphoSite	P97875.
Proteomic databases
PRIDE	P97875.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000050687; ENSMUSP00000059724; ENSMUSG00000034271. ENSMUST00000171754; ENSMUSP00000129985; ENSMUSG00000034271. ENSMUST00000177587; ENSMUSP00000136823; ENSMUSG00000034271.
GeneID	81703.
KEGG	mmu:81703.
UCSC	uc007ohb.1. mouse.
Organism-specific databases
CTD	122953.
MGI	MGI:1932093. Jdp2.
Phylogenomic databases
eggNOG	NOG280450.
GeneTree	ENSGT00550000074426.
HOGENOM	HOG000034126.
HOVERGEN	HBG057870.
InParanoid	P97875.
KO	K09033.
OMA	XESERLE.
OrthoDB	EOG4FFD36.
Gene expression databases
ArrayExpress	P97875.
Bgee	P97875.
Genevestigator	P97875.
Family and domain databases
InterPro	IPR004827. bZIP. IPR000837. Leuzip_Fos. [Graphical view]
Pfam	PF00170. bZIP_1. 1 hit. [Graphical view]
PRINTS	PR00042. LEUZIPPRFOS.
SMART	SM00338. BRLZ. 1 hit. [Graphical view]
PROSITE	PS50217. BZIP. 1 hit. PS00036. BZIP_BASIC. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	350432.
SOURCE	Search...

Entry information

Entry name

JDP2_MOUSE

Accession

Primary (citable) accession number: P97875

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 29, 2008
Last sequence update:	June 1, 1998
Last modified:	April 3, 2013
This is version 98 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents