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P97875 (JDP2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 107. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Jun dimerization protein 2
Gene names
Name:Jdp2
Synonyms:Jundm2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length163 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Component of the AP-1 transcription factor that represses transactivation mediated by the Jun family of proteins. Involved in a variety of transcriptional responses associated with AP-1, such as UV-induced apoptosis, cell differentiation, tumorigenesis and antitumogeneris. Can also function as a repressor by recruiting histone deacetylase 3/HDAC3 to the promoter region of JUN. May control transcription via direct regulation of the modification of histones and the assembly of chromatin By similarity. Ref.1 Ref.5

Subunit structure

Forms a homodimer or heterodimer with JUN, JUNB, JUND, CEBPG and ATF2 thereby inhibiting transactivation by JUN, ATF2 and CEBPG By similarity. Binds multiple DNA elements such as cAMP-response element (CRE) and TPA response element (TRE) either as homodimer or heterodimer. Interacts with IRF2BP1 By similarity. Ref.3 Ref.4 Ref.6

Subcellular location

Nucleus Probable.

Tissue specificity

Ubiquitously expressed in all adult tissues tested as well in embryos. Ref.3

Post-translational modification

Phosphorylation of Thr-148 by MAPK8 in response to different stress conditions such as, UV irradiation, oxidatives stress and anisomycin treatments.

Polyubiquitinated; probably by IRF2BP1 By similarity.

Sequence similarities

Belongs to the bZIP family. ATF subfamily.

Contains 1 bZIP (basic-leucine zipper) domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 163163Jun dimerization protein 2
PRO_0000331131

Regions

Domain72 – 13564bZIP
Region74 – 9623Basic motif By similarity
Region100 – 12829Leucine-zipper By similarity

Amino acid modifications

Modified residue1481Phosphothreonine; by MAPK8 Ref.4 Ref.6

Experimental info

Mutagenesis1481T → A: Blocks phosphorylation by MAPK8. Ref.4 Ref.6

Sequences

Sequence LengthMass (Da)Tools
P97875 [UniParc].

Last modified June 1, 1998. Version 2.
Checksum: A8AB65A7D20564F8

FASTA16318,675
        10         20         30         40         50         60 
MMPGQIPDPS VTAGSLPGLG PLTGLPSSAL TTEELKYADI RNIGAMIAPL HFLEVKLGKR 

        70         80         90        100        110        120 
PQPVKSELDE EEERRKRRRE KNKVAAARCR NKKKERTEFL QRESERLELM NAELKTQIEE 

       130        140        150        160 
LKLERQQLIL MLNRHRPTCI VRTDSVRTPE SEGNPLLEQL DKK 

« Hide

References

« Hide 'large scale' references
[1]"Jun dimerization protein 2 (JDP2), a member of the AP-1 family of transcription factor, mediates osteoclast differentiation induced by RANKL."
Kawaida R., Ohtsuka T., Okutsu J., Takahashi T., Kadono Y., Oda H., Hikita A., Nakamura K., Tanaka S., Furukawa H.
J. Exp. Med. 197:1029-1035(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Czech II.
Tissue: Mammary tumor.
[3]"Identification of mouse Jun dimerization protein 2 as a novel repressor of ATF-2."
Jin C., Ugai H., Song J., Murata T., Nili F., Sun K., Horikoshi M., Yokoyama K.K.
FEBS Lett. 489:34-41(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY, INTERACTION WITH ATF2, DNA-BINDING.
[4]"The AP-1 repressor, JDP2, is a bona fide substrate for the c-Jun N-terminal kinase."
Katz S., Heinrich R., Aronheim A.
FEBS Lett. 506:196-200(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH ATF2, PHOSPHORYLATION AT THR-148 BY MAPK8, MUTAGENESIS OF THR-148.
[5]"The c-Jun dimerization protein 2 inhibits cell transformation and acts as a tumor suppressor gene."
Heinrich R., Livne E., Ben-Izhak O., Aronheim A.
J. Biol. Chem. 279:5708-5715(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[6]"Phosphorylation of two eukaryotic transcription factors, Jun dimerization protein 2 and activation transcription factor 2, in Escherichia coli by Jun N-terminal kinase 1."
Murata T., Shinozuka Y., Obata Y., Yokoyama K.K.
Anal. Biochem. 376:115-121(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH ATF2, PHOSPHORYLATION AT THR-148 BY MAPK8/JNK1, MUTAGENESIS OF THR-148.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB077438 mRNA. Translation: BAB83764.1.
BC019780 mRNA. Translation: AAH19780.1.
RefSeqNP_001191981.1. NM_001205052.1.
NP_001191982.1. NM_001205053.1.
NP_112149.2. NM_030887.2.
UniGeneMm.103560.

3D structure databases

ProteinModelPortalP97875.
SMRP97875. Positions 76-126.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid219888. 14 interactions.
STRING10090.ENSMUSP00000059724.

PTM databases

PhosphoSiteP97875.

Proteomic databases

PRIDEP97875.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000050687; ENSMUSP00000059724; ENSMUSG00000034271.
ENSMUST00000171754; ENSMUSP00000129985; ENSMUSG00000034271.
ENSMUST00000177587; ENSMUSP00000136823; ENSMUSG00000034271.
GeneID81703.
KEGGmmu:81703.
UCSCuc007ohb.1. mouse.

Organism-specific databases

CTD122953.
MGIMGI:1932093. Jdp2.

Phylogenomic databases

eggNOGNOG280450.
GeneTreeENSGT00730000110847.
HOGENOMHOG000034126.
HOVERGENHBG057870.
InParanoidP97875.
KOK09033.
OMAQEFGTML.
OrthoDBEOG70S777.
PhylomeDBP97875.
TreeFamTF326301.

Gene expression databases

ArrayExpressP97875.
BgeeP97875.
GenevestigatorP97875.

Family and domain databases

InterProIPR004827. bZIP.
IPR000837. Leuzip_Fos.
[Graphical view]
PfamPF00170. bZIP_1. 1 hit.
[Graphical view]
PRINTSPR00042. LEUZIPPRFOS.
SMARTSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio350432.
PROP97875.
SOURCESearch...

Entry information

Entry nameJDP2_MOUSE
AccessionPrimary (citable) accession number: P97875
Entry history
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: June 1, 1998
Last modified: April 16, 2014
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot