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Protein

Lysyl oxidase homolog 1

Gene

Loxl1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Active on elastin and collagen substrates.By similarity

Cofactori

Protein has several cofactor binding sites:

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi482CopperSequence analysis1
Metal bindingi484CopperSequence analysis1
Metal bindingi486CopperSequence analysis1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Lysyl oxidase homolog 1 (EC:1.4.3.-)
Alternative name(s):
Lysyl oxidase 2
Lysyl oxidase-like protein 1
Gene namesi
Name:Loxl1
Synonyms:Lox2, Loxl
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:106096. Loxl1.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: UniProtKB-SubCell
  • proteinaceous extracellular matrix Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
PropeptideiPRO_000001853029 – 94By similarityAdd BLAST66
ChainiPRO_000001853195 – 607Lysyl oxidase homolog 1Add BLAST513

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi428 ↔ 434By similarity
Disulfide bondi481 ↔ 530By similarity
Cross-linki510 ↔ 545Lysine tyrosylquinone (Lys-Tyr)By similarity
Disulfide bondi514 ↔ 520By similarity
Disulfide bondi541 ↔ 551By similarity
Modified residuei5452',4',5'-topaquinoneBy similarity1
Disulfide bondi588 ↔ 602By similarity

Post-translational modificationi

The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, LTQ, TPQ

Proteomic databases

MaxQBiP97873.
PaxDbiP97873.
PeptideAtlasiP97873.
PRIDEiP97873.

PTM databases

iPTMnetiP97873.
PhosphoSitePlusiP97873.

Expressioni

Gene expression databases

BgeeiENSMUSG00000032334.
CleanExiMM_LOXL1.

Interactioni

Protein-protein interaction databases

BioGridi201192. 1 interactor.
IntActiP97873. 3 interactors.
MINTiMINT-6743519.
STRINGi10090.ENSMUSP00000057406.

Structurei

3D structure databases

ProteinModelPortaliP97873.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni403 – 607Lysyl-oxidase likeAdd BLAST205

Sequence similaritiesi

Belongs to the lysyl oxidase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IHTH. Eukaryota.
ENOG41101E4. LUCA.
HOGENOMiHOG000234262.
HOVERGENiHBG000226.
InParanoidiP97873.
KOiK14678.
PhylomeDBiP97873.
TreeFamiTF326061.

Family and domain databases

InterProiIPR001695. Lysyl_oxidase.
IPR019828. Lysyl_oxidase_CS.
[Graphical view]
PfamiPF01186. Lysyl_oxidase. 1 hit.
[Graphical view]
PRINTSiPR00074. LYSYLOXIDASE.
PROSITEiPS00926. LYSYL_OXIDASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P97873-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALAGAGSQL RTLVWSACLC VLVHGQQAQP GQGSDPGRWR QLIQWENNGQ
60 70 80 90 100
VYSLLNSGSE YVPAGPQRGE TSSRVLLAGA PQTSQRRSQG GPRRRQAPSL
110 120 130 140 150
PLPGRVGSDT VRGQTRHPFG FGQVPDNWRE VAVGDSTGMA RARTSVSQQR
160 170 180 190 200
HGGSASSSVS ASAFATTYRQ PSPYPQQFPY PQAPFVNQYE NYDPASRTYE
210 220 230 240 250
QGYVYYRGAG GGMGAGAAAV ASAGVIYPFQ PRARYEDYGG GGGEEQPEYP
260 270 280 290 300
AQGFYPAPER PYVPQPQPQP QPQPQPQPQP SDGLDRRYSH SLYNEGTPGF
310 320 330 340 350
EQAYPDPSTD VSQAPAGAGG TYGGAGDPRL GWYPPYAANV PPEAYVPPRA
360 370 380 390 400
VEPQPPFRVL EPPYLPVRSS DAPSQGGERN GAQQGRLSVG SVYRPNQNGR
410 420 430 440 450
GLPDLVPDPN YVQASTYVQR AHLYSLRCAA EEKCLASTAY APEATDYDLR
460 470 480 490 500
VLLRFPQRVK NQGTADFLPN RPRHTWEWHS CHQHYHSMDE FSHYDLLDAS
510 520 530 540 550
TGKKVAEGHK ASFCLEDSTC DFGNLKRYAC TSHTQGLSPG CYDTYNADID
560 570 580 590 600
CQWIDITDVQ PGNYILKVHV NPKYIVLESD FTNNVVRCNI HYTGRYVSTT

NCKIVQS
Length:607
Mass (Da):66,506
Last modified:September 19, 2003 - v3
Checksum:i7BA8144F09E96C94
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti173P → S in AAH37999 (PubMed:15489334).Curated1
Sequence conflicti208 – 210GAG → HAS in AAH03973 (PubMed:15489334).Curated3
Sequence conflicti321T → I in AAH03973 (PubMed:15489334).Curated1
Sequence conflicti500S → A in AAB86802 (PubMed:9250877).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF357006 mRNA. Translation: AAK97375.1.
BC003973 mRNA. Translation: AAH03973.1.
BC037999 mRNA. Translation: AAH37999.1.
AH006767 Genomic DNA. Translation: AAC53067.1.
U79144 mRNA. Translation: AAB86802.1.
CCDSiCCDS52813.1.
RefSeqiNP_034859.2. NM_010729.3.
UniGeneiMm.250492.

Genome annotation databases

GeneIDi16949.
KEGGimmu:16949.
UCSCiuc009pwv.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF357006 mRNA. Translation: AAK97375.1.
BC003973 mRNA. Translation: AAH03973.1.
BC037999 mRNA. Translation: AAH37999.1.
AH006767 Genomic DNA. Translation: AAC53067.1.
U79144 mRNA. Translation: AAB86802.1.
CCDSiCCDS52813.1.
RefSeqiNP_034859.2. NM_010729.3.
UniGeneiMm.250492.

3D structure databases

ProteinModelPortaliP97873.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201192. 1 interactor.
IntActiP97873. 3 interactors.
MINTiMINT-6743519.
STRINGi10090.ENSMUSP00000057406.

PTM databases

iPTMnetiP97873.
PhosphoSitePlusiP97873.

Proteomic databases

MaxQBiP97873.
PaxDbiP97873.
PeptideAtlasiP97873.
PRIDEiP97873.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi16949.
KEGGimmu:16949.
UCSCiuc009pwv.2. mouse.

Organism-specific databases

CTDi4016.
MGIiMGI:106096. Loxl1.

Phylogenomic databases

eggNOGiENOG410IHTH. Eukaryota.
ENOG41101E4. LUCA.
HOGENOMiHOG000234262.
HOVERGENiHBG000226.
InParanoidiP97873.
KOiK14678.
PhylomeDBiP97873.
TreeFamiTF326061.

Miscellaneous databases

PROiP97873.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032334.
CleanExiMM_LOXL1.

Family and domain databases

InterProiIPR001695. Lysyl_oxidase.
IPR019828. Lysyl_oxidase_CS.
[Graphical view]
PfamiPF01186. Lysyl_oxidase. 1 hit.
[Graphical view]
PRINTSiPR00074. LYSYLOXIDASE.
PROSITEiPS00926. LYSYL_OXIDASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLOXL1_MOUSE
AccessioniPrimary (citable) accession number: P97873
Secondary accession number(s): Q91ZY4, Q99KX3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: September 19, 2003
Last modified: November 2, 2016
This is version 124 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.