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P97873

- LOXL1_MOUSE

UniProt

P97873 - LOXL1_MOUSE

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Protein
Lysyl oxidase homolog 1
Gene
Loxl1, Lox2, Loxl
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Active on elastin and collagen substrates By similarity.

Cofactori

Copper By similarity.
Contains 1 lysine tyrosylquinone By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi482 – 4821Copper Reviewed prediction
Metal bindingi484 – 4841Copper Reviewed prediction
Metal bindingi486 – 4861Copper Reviewed prediction

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor Source: MGI
  3. protein binding Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Copper, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_196515. Crosslinking of collagen fibrils.
REACT_198996. Elastic fibre formation.

Names & Taxonomyi

Protein namesi
Recommended name:
Lysyl oxidase homolog 1 (EC:1.4.3.-)
Alternative name(s):
Lysyl oxidase 2
Lysyl oxidase-like protein 1
Gene namesi
Name:Loxl1
Synonyms:Lox2, Loxl
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:106096. Loxl1.

Subcellular locationi

Secretedextracellular space Reviewed prediction

GO - Cellular componenti

  1. extracellular matrix Source: MGI
  2. extracellular space Source: UniProtKB-SubCell
  3. proteinaceous extracellular matrix Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828 Reviewed prediction
Add
BLAST
Propeptidei29 – 9466 By similarity
PRO_0000018530Add
BLAST
Chaini95 – 607513Lysyl oxidase homolog 1
PRO_0000018531Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi428 ↔ 434 By similarity
Disulfide bondi481 ↔ 530 By similarity
Cross-linki510 ↔ 545Lysine tyrosylquinone (Lys-Tyr) By similarity
Disulfide bondi514 ↔ 520 By similarity
Disulfide bondi541 ↔ 551 By similarity
Modified residuei545 – 54512',4',5'-topaquinone By similarity
Disulfide bondi588 ↔ 602 By similarity

Post-translational modificationi

The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, LTQ, TPQ

Proteomic databases

PaxDbiP97873.
PRIDEiP97873.

PTM databases

PhosphoSiteiP97873.

Expressioni

Gene expression databases

BgeeiP97873.
CleanExiMM_LOXL1.
GenevestigatoriP97873.

Interactioni

Protein-protein interaction databases

BioGridi201192. 1 interaction.
IntActiP97873. 2 interactions.
MINTiMINT-6743519.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni403 – 607205Lysyl-oxidase like
Add
BLAST

Sequence similaritiesi

Belongs to the lysyl oxidase family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG77510.
GeneTreeiENSGT00740000115025.
HOGENOMiHOG000234262.
HOVERGENiHBG000226.
InParanoidiP97873.
KOiK14678.
OrthoDBiEOG7SN8C6.
PhylomeDBiP97873.
TreeFamiTF326061.

Family and domain databases

InterProiIPR001695. Lysyl_oxidase.
IPR019828. Lysyl_oxidase_CS.
[Graphical view]
PfamiPF01186. Lysyl_oxidase. 1 hit.
[Graphical view]
PRINTSiPR00074. LYSYLOXIDASE.
PROSITEiPS00926. LYSYL_OXIDASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P97873-1 [UniParc]FASTAAdd to Basket

« Hide

MALAGAGSQL RTLVWSACLC VLVHGQQAQP GQGSDPGRWR QLIQWENNGQ    50
VYSLLNSGSE YVPAGPQRGE TSSRVLLAGA PQTSQRRSQG GPRRRQAPSL 100
PLPGRVGSDT VRGQTRHPFG FGQVPDNWRE VAVGDSTGMA RARTSVSQQR 150
HGGSASSSVS ASAFATTYRQ PSPYPQQFPY PQAPFVNQYE NYDPASRTYE 200
QGYVYYRGAG GGMGAGAAAV ASAGVIYPFQ PRARYEDYGG GGGEEQPEYP 250
AQGFYPAPER PYVPQPQPQP QPQPQPQPQP SDGLDRRYSH SLYNEGTPGF 300
EQAYPDPSTD VSQAPAGAGG TYGGAGDPRL GWYPPYAANV PPEAYVPPRA 350
VEPQPPFRVL EPPYLPVRSS DAPSQGGERN GAQQGRLSVG SVYRPNQNGR 400
GLPDLVPDPN YVQASTYVQR AHLYSLRCAA EEKCLASTAY APEATDYDLR 450
VLLRFPQRVK NQGTADFLPN RPRHTWEWHS CHQHYHSMDE FSHYDLLDAS 500
TGKKVAEGHK ASFCLEDSTC DFGNLKRYAC TSHTQGLSPG CYDTYNADID 550
CQWIDITDVQ PGNYILKVHV NPKYIVLESD FTNNVVRCNI HYTGRYVSTT 600
NCKIVQS 607
Length:607
Mass (Da):66,506
Last modified:September 19, 2003 - v3
Checksum:i7BA8144F09E96C94
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti173 – 1731P → S in AAH37999. 1 Publication
Sequence conflicti208 – 2103GAG → HAS in AAH03973. 1 Publication
Sequence conflicti321 – 3211T → I in AAH03973. 1 Publication
Sequence conflicti500 – 5001S → A in AAB86802. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF357006 mRNA. Translation: AAK97375.1.
BC003973 mRNA. Translation: AAH03973.1.
BC037999 mRNA. Translation: AAH37999.1.
AH006767 Genomic DNA. Translation: AAC53067.1.
U79144 mRNA. Translation: AAB86802.1.
CCDSiCCDS52813.1.
RefSeqiNP_034859.2. NM_010729.3.
UniGeneiMm.250492.

Genome annotation databases

EnsembliENSMUST00000061799; ENSMUSP00000057406; ENSMUSG00000032334.
GeneIDi16949.
KEGGimmu:16949.
UCSCiuc009pwv.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF357006 mRNA. Translation: AAK97375.1 .
BC003973 mRNA. Translation: AAH03973.1 .
BC037999 mRNA. Translation: AAH37999.1 .
AH006767 Genomic DNA. Translation: AAC53067.1 .
U79144 mRNA. Translation: AAB86802.1 .
CCDSi CCDS52813.1.
RefSeqi NP_034859.2. NM_010729.3.
UniGenei Mm.250492.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 201192. 1 interaction.
IntActi P97873. 2 interactions.
MINTi MINT-6743519.

PTM databases

PhosphoSitei P97873.

Proteomic databases

PaxDbi P97873.
PRIDEi P97873.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000061799 ; ENSMUSP00000057406 ; ENSMUSG00000032334 .
GeneIDi 16949.
KEGGi mmu:16949.
UCSCi uc009pwv.2. mouse.

Organism-specific databases

CTDi 4016.
MGIi MGI:106096. Loxl1.

Phylogenomic databases

eggNOGi NOG77510.
GeneTreei ENSGT00740000115025.
HOGENOMi HOG000234262.
HOVERGENi HBG000226.
InParanoidi P97873.
KOi K14678.
OrthoDBi EOG7SN8C6.
PhylomeDBi P97873.
TreeFami TF326061.

Enzyme and pathway databases

Reactomei REACT_196515. Crosslinking of collagen fibrils.
REACT_198996. Elastic fibre formation.

Miscellaneous databases

NextBioi 290996.
PROi P97873.
SOURCEi Search...

Gene expression databases

Bgeei P97873.
CleanExi MM_LOXL1.
Genevestigatori P97873.

Family and domain databases

InterProi IPR001695. Lysyl_oxidase.
IPR019828. Lysyl_oxidase_CS.
[Graphical view ]
Pfami PF01186. Lysyl_oxidase. 1 hit.
[Graphical view ]
PRINTSi PR00074. LYSYLOXIDASE.
PROSITEi PS00926. LYSYL_OXIDASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of the recombinant and natural forms of mature lysyl oxidase-like 1."
    Seve S., Borel A., Gleyzal C., Farjanel J., Eichenberger D., Font B., Sommer P.
    Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Mammary gland.
  3. "Genetic mapping of lysyl oxidase-2 (Loxl) on mouse chromosome 9."
    Tchernev V.T., Yang T.P., Kingsmore S.F.
    Mamm. Genome 8:621-622(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 498-607.
  4. "An intron capture strategy used to identify and map a lysyl oxidase-like gene on chromosome 9 in the mouse."
    Wydner K.S., Kim Y., Csiszar K., Boyd C.D., Passmore H.C.
    Genomics 40:342-345(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 526-540.
    Strain: C57BL/6J.

Entry informationi

Entry nameiLOXL1_MOUSE
AccessioniPrimary (citable) accession number: P97873
Secondary accession number(s): Q91ZY4, Q99KX3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: September 19, 2003
Last modified: September 3, 2014
This is version 105 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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