Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P97873 (LOXL1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 104. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lysyl oxidase homolog 1

EC=1.4.3.-
Alternative name(s):
Lysyl oxidase 2
Lysyl oxidase-like protein 1
Gene names
Name:Loxl1
Synonyms:Lox2, Loxl
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length607 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Active on elastin and collagen substrates By similarity.

Cofactor

Copper By similarity.

Contains 1 lysine tyrosylquinone By similarity.

Subcellular location

Secretedextracellular space Potential.

Post-translational modification

The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.

Sequence similarities

Belongs to the lysyl oxidase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2828 Potential
Propeptide29 – 9466 By similarity
PRO_0000018530
Chain95 – 607513Lysyl oxidase homolog 1
PRO_0000018531

Regions

Region403 – 607205Lysyl-oxidase like

Sites

Metal binding4821Copper Potential
Metal binding4841Copper Potential
Metal binding4861Copper Potential

Amino acid modifications

Modified residue54512',4',5'-topaquinone By similarity
Disulfide bond428 ↔ 434 By similarity
Disulfide bond481 ↔ 530 By similarity
Disulfide bond514 ↔ 520 By similarity
Disulfide bond541 ↔ 551 By similarity
Disulfide bond588 ↔ 602 By similarity
Cross-link510 ↔ 545Lysine tyrosylquinone (Lys-Tyr) By similarity

Experimental info

Sequence conflict1731P → S in AAH37999. Ref.2
Sequence conflict208 – 2103GAG → HAS in AAH03973. Ref.2
Sequence conflict3211T → I in AAH03973. Ref.2
Sequence conflict5001S → A in AAB86802. Ref.3

Sequences

Sequence LengthMass (Da)Tools
P97873 [UniParc].

Last modified September 19, 2003. Version 3.
Checksum: 7BA8144F09E96C94

FASTA60766,506
        10         20         30         40         50         60 
MALAGAGSQL RTLVWSACLC VLVHGQQAQP GQGSDPGRWR QLIQWENNGQ VYSLLNSGSE 

        70         80         90        100        110        120 
YVPAGPQRGE TSSRVLLAGA PQTSQRRSQG GPRRRQAPSL PLPGRVGSDT VRGQTRHPFG 

       130        140        150        160        170        180 
FGQVPDNWRE VAVGDSTGMA RARTSVSQQR HGGSASSSVS ASAFATTYRQ PSPYPQQFPY 

       190        200        210        220        230        240 
PQAPFVNQYE NYDPASRTYE QGYVYYRGAG GGMGAGAAAV ASAGVIYPFQ PRARYEDYGG 

       250        260        270        280        290        300 
GGGEEQPEYP AQGFYPAPER PYVPQPQPQP QPQPQPQPQP SDGLDRRYSH SLYNEGTPGF 

       310        320        330        340        350        360 
EQAYPDPSTD VSQAPAGAGG TYGGAGDPRL GWYPPYAANV PPEAYVPPRA VEPQPPFRVL 

       370        380        390        400        410        420 
EPPYLPVRSS DAPSQGGERN GAQQGRLSVG SVYRPNQNGR GLPDLVPDPN YVQASTYVQR 

       430        440        450        460        470        480 
AHLYSLRCAA EEKCLASTAY APEATDYDLR VLLRFPQRVK NQGTADFLPN RPRHTWEWHS 

       490        500        510        520        530        540 
CHQHYHSMDE FSHYDLLDAS TGKKVAEGHK ASFCLEDSTC DFGNLKRYAC TSHTQGLSPG 

       550        560        570        580        590        600 
CYDTYNADID CQWIDITDVQ PGNYILKVHV NPKYIVLESD FTNNVVRCNI HYTGRYVSTT 


NCKIVQS 

« Hide

References

« Hide 'large scale' references
[1]"Identification of the recombinant and natural forms of mature lysyl oxidase-like 1."
Seve S., Borel A., Gleyzal C., Farjanel J., Eichenberger D., Font B., Sommer P.
Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Mammary gland.
[3]"Genetic mapping of lysyl oxidase-2 (Loxl) on mouse chromosome 9."
Tchernev V.T., Yang T.P., Kingsmore S.F.
Mamm. Genome 8:621-622(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 498-607.
[4]"An intron capture strategy used to identify and map a lysyl oxidase-like gene on chromosome 9 in the mouse."
Wydner K.S., Kim Y., Csiszar K., Boyd C.D., Passmore H.C.
Genomics 40:342-345(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 526-540.
Strain: C57BL/6J.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF357006 mRNA. Translation: AAK97375.1.
BC003973 mRNA. Translation: AAH03973.1.
BC037999 mRNA. Translation: AAH37999.1.
AH006767 Genomic DNA. Translation: AAC53067.1.
U79144 mRNA. Translation: AAB86802.1.
CCDSCCDS52813.1.
RefSeqNP_034859.2. NM_010729.3.
UniGeneMm.250492.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid201192. 1 interaction.
IntActP97873. 2 interactions.
MINTMINT-6743519.

PTM databases

PhosphoSiteP97873.

Proteomic databases

PaxDbP97873.
PRIDEP97873.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000061799; ENSMUSP00000057406; ENSMUSG00000032334.
GeneID16949.
KEGGmmu:16949.
UCSCuc009pwv.2. mouse.

Organism-specific databases

CTD4016.
MGIMGI:106096. Loxl1.

Phylogenomic databases

eggNOGNOG77510.
GeneTreeENSGT00740000115025.
HOGENOMHOG000234262.
HOVERGENHBG000226.
InParanoidP97873.
KOK14678.
OrthoDBEOG7SN8C6.
PhylomeDBP97873.
TreeFamTF326061.

Gene expression databases

BgeeP97873.
CleanExMM_LOXL1.
GenevestigatorP97873.

Family and domain databases

InterProIPR001695. Lysyl_oxidase.
IPR019828. Lysyl_oxidase_CS.
[Graphical view]
PfamPF01186. Lysyl_oxidase. 1 hit.
[Graphical view]
PRINTSPR00074. LYSYLOXIDASE.
PROSITEPS00926. LYSYL_OXIDASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio290996.
PROP97873.
SOURCESearch...

Entry information

Entry nameLOXL1_MOUSE
AccessionPrimary (citable) accession number: P97873
Secondary accession number(s): Q91ZY4, Q99KX3
Entry history
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: September 19, 2003
Last modified: July 9, 2014
This is version 104 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot