Reviewed, UniProtKB/Swiss-Prot P97873 (LOXL1_MOUSE)

Names and origin

Protein names

Recommended name:
    Lysyl oxidase homolog 1
    EC=1.4.3.-
Alternative name(s):
    Lysyl oxidase-like protein 1
    Lysyl oxidase 2

Gene names

Name:	Loxl1
Synonyms:	Lox2, Loxl

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	607 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Active on elastin and collagen substrates By similarity.
Cofactor	Copper By similarity. Contains 1 lysine tyrosylquinone By similarity.
Subcellular location	Secreted › extracellular space Potential.
Post-translational modification	The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.
Sequence similarities	Belongs to the lysyl oxidase family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Ligand	Copper Metal-binding
Molecular function	Oxidoreductase
PTM	Cleavage on pair of basic residues LTQ TPQ
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	extracellular space Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	copper ion binding Inferred from electronic annotation. Source: UniProtKB-KW oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor Inferred from direct assay. Source: MGI protein binding Inferred from physical interaction. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 28	28	Potential
	Propeptide	29 – 94	66	By similarity		PRO_0000018530
	Chain	95 – 607	513	Lysyl oxidase homolog 1		PRO_0000018531
Regions
	Region	403 – 607	205	Lysyl-oxidase like
Sites
	Metal binding	482	1	Copper Potential
	Metal binding	484	1	Copper Potential
	Metal binding	486	1	Copper Potential
Amino acid modifications
	Modified residue	545	1	2',4',5'-topaquinone By similarity
	Cross-link	510 ↔ 545		Lysine tyrosylquinone (Lys-Tyr) By similarity
Experimental info
	Sequence conflict	173	1	P → S in AAH37999. Ref.2
	Sequence conflict	208 – 210	3	GAG → HAS in AAH03973. Ref.2
	Sequence conflict	321	1	T → I in AAH03973. Ref.2
	Sequence conflict	500	1	S → A in AAB86802. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	P97873-1 [UniParc]. Last modified September 19, 2003. Version 3. Checksum: 7BA8144F09E96C94	FASTA	607	66,506
	10 20 30 40 50 60 MALAGAGSQL RTLVWSACLC VLVHGQQAQP GQGSDPGRWR QLIQWENNGQ VYSLLNSGSE 70 80 90 100 110 120 YVPAGPQRGE TSSRVLLAGA PQTSQRRSQG GPRRRQAPSL PLPGRVGSDT VRGQTRHPFG 130 140 150 160 170 180 FGQVPDNWRE VAVGDSTGMA RARTSVSQQR HGGSASSSVS ASAFATTYRQ PSPYPQQFPY 190 200 210 220 230 240 PQAPFVNQYE NYDPASRTYE QGYVYYRGAG GGMGAGAAAV ASAGVIYPFQ PRARYEDYGG 250 260 270 280 290 300 GGGEEQPEYP AQGFYPAPER PYVPQPQPQP QPQPQPQPQP SDGLDRRYSH SLYNEGTPGF 310 320 330 340 350 360 EQAYPDPSTD VSQAPAGAGG TYGGAGDPRL GWYPPYAANV PPEAYVPPRA VEPQPPFRVL 370 380 390 400 410 420 EPPYLPVRSS DAPSQGGERN GAQQGRLSVG SVYRPNQNGR GLPDLVPDPN YVQASTYVQR 430 440 450 460 470 480 AHLYSLRCAA EEKCLASTAY APEATDYDLR VLLRFPQRVK NQGTADFLPN RPRHTWEWHS 490 500 510 520 530 540 CHQHYHSMDE FSHYDLLDAS TGKKVAEGHK ASFCLEDSTC DFGNLKRYAC TSHTQGLSPG 550 560 570 580 590 600 CYDTYNADID CQWIDITDVQ PGNYILKVHV NPKYIVLESD FTNNVVRCNI HYTGRYVSTT NCKIVQS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of the recombinant and natural forms of mature lysyl oxidase-like 1." Seve S., Borel A., Gleyzal C., Farjanel J., Eichenberger D., Font B., Sommer P. Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Mammary gland.
[3]	"Genetic mapping of lysyl oxidase-2 (Loxl) on mouse chromosome 9." Tchernev V.T., Yang T.P., Kingsmore S.F. Mamm. Genome 8:621-622(1997) [PubMed: 9250877] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 498-607.
[4]	"An intron capture strategy used to identify and map a lysyl oxidase-like gene on chromosome 9 in the mouse." Wydner K.S., Kim Y., Csiszar K., Boyd C.D., Passmore H.C. Genomics 40:342-345(1997) [PubMed: 9119402] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 526-540. Strain: C57BL/6J.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF357006 mRNA. Translation: AAK97375.1. BC003973 mRNA. Translation: AAH03973.1. BC037999 mRNA. Translation: AAH37999.1. U65660, U65659 Genomic DNA. Translation: AAC53067.1. U79144 mRNA. Translation: AAB86802.1.
IPI	IPI00380136.
RefSeq	NP_034859.2.
UniGene	Mm.250492
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSMUSG00000032334. Mus musculus. [Contig view]
GeneID	16949.
KEGG	mmu:16949.
Organism-specific databases
MGI	MGI:106096. Loxl1.
Phylogenomic databases
HOGENOM	P97873.
HOVERGEN	P97873.
Gene expression databases
ArrayExpress	P97873.
Bgee	P97873.
CleanEx	MM_LOXL1.
GermOnline	ENSMUSG00000032334. Mus musculus.
Family and domain databases
InterPro	IPR001695. Lysyl_oxidase. IPR019828. Lysyl_oxidase_CS. [Graphical view]
Pfam	PF01186. Lysyl_oxidase. 1 hit. [Graphical view]
PRINTS	PR00074. LYSYLOXIDASE.
PROSITE	PS00926. LYSYL_OXIDASE. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	290996.
SOURCE	Search...

Entry information

Entry name

LOXL1_MOUSE

Accession

Primary (citable) accession number: P97873
Secondary accession number(s): Q91ZY4, Q99KX3

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
Last sequence update:	September 19, 2003
Last modified:	June 16, 2009
This is version 68 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)