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P97873

- LOXL1_MOUSE

UniProt

P97873 - LOXL1_MOUSE

Protein

Lysyl oxidase homolog 1

Gene

Loxl1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 3 (19 Sep 2003)
      Previous versions | rss
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    Functioni

    Active on elastin and collagen substrates.By similarity

    Cofactori

    Copper.By similarity
    Contains 1 lysine tyrosylquinone.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi482 – 4821CopperSequence Analysis
    Metal bindingi484 – 4841CopperSequence Analysis
    Metal bindingi486 – 4861CopperSequence Analysis

    GO - Molecular functioni

    1. copper ion binding Source: InterPro
    2. oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor Source: MGI
    3. protein binding Source: MGI

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Copper, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_196515. Crosslinking of collagen fibrils.
    REACT_198996. Elastic fibre formation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lysyl oxidase homolog 1 (EC:1.4.3.-)
    Alternative name(s):
    Lysyl oxidase 2
    Lysyl oxidase-like protein 1
    Gene namesi
    Name:Loxl1
    Synonyms:Lox2, Loxl
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 9

    Organism-specific databases

    MGIiMGI:106096. Loxl1.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular matrix Source: MGI
    2. extracellular space Source: UniProtKB-SubCell
    3. proteinaceous extracellular matrix Source: Ensembl

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2828Sequence AnalysisAdd
    BLAST
    Propeptidei29 – 9466By similarityPRO_0000018530Add
    BLAST
    Chaini95 – 607513Lysyl oxidase homolog 1PRO_0000018531Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi428 ↔ 434By similarity
    Disulfide bondi481 ↔ 530By similarity
    Cross-linki510 ↔ 545Lysine tyrosylquinone (Lys-Tyr)By similarity
    Disulfide bondi514 ↔ 520By similarity
    Disulfide bondi541 ↔ 551By similarity
    Modified residuei545 – 54512',4',5'-topaquinoneBy similarity
    Disulfide bondi588 ↔ 602By similarity

    Post-translational modificationi

    The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond, LTQ, TPQ

    Proteomic databases

    PaxDbiP97873.
    PRIDEiP97873.

    PTM databases

    PhosphoSiteiP97873.

    Expressioni

    Gene expression databases

    BgeeiP97873.
    CleanExiMM_LOXL1.
    GenevestigatoriP97873.

    Interactioni

    Protein-protein interaction databases

    BioGridi201192. 1 interaction.
    IntActiP97873. 2 interactions.
    MINTiMINT-6743519.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni403 – 607205Lysyl-oxidase likeAdd
    BLAST

    Sequence similaritiesi

    Belongs to the lysyl oxidase family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG77510.
    GeneTreeiENSGT00740000115025.
    HOGENOMiHOG000234262.
    HOVERGENiHBG000226.
    InParanoidiP97873.
    KOiK14678.
    OrthoDBiEOG7SN8C6.
    PhylomeDBiP97873.
    TreeFamiTF326061.

    Family and domain databases

    InterProiIPR001695. Lysyl_oxidase.
    IPR019828. Lysyl_oxidase_CS.
    [Graphical view]
    PfamiPF01186. Lysyl_oxidase. 1 hit.
    [Graphical view]
    PRINTSiPR00074. LYSYLOXIDASE.
    PROSITEiPS00926. LYSYL_OXIDASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P97873-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALAGAGSQL RTLVWSACLC VLVHGQQAQP GQGSDPGRWR QLIQWENNGQ    50
    VYSLLNSGSE YVPAGPQRGE TSSRVLLAGA PQTSQRRSQG GPRRRQAPSL 100
    PLPGRVGSDT VRGQTRHPFG FGQVPDNWRE VAVGDSTGMA RARTSVSQQR 150
    HGGSASSSVS ASAFATTYRQ PSPYPQQFPY PQAPFVNQYE NYDPASRTYE 200
    QGYVYYRGAG GGMGAGAAAV ASAGVIYPFQ PRARYEDYGG GGGEEQPEYP 250
    AQGFYPAPER PYVPQPQPQP QPQPQPQPQP SDGLDRRYSH SLYNEGTPGF 300
    EQAYPDPSTD VSQAPAGAGG TYGGAGDPRL GWYPPYAANV PPEAYVPPRA 350
    VEPQPPFRVL EPPYLPVRSS DAPSQGGERN GAQQGRLSVG SVYRPNQNGR 400
    GLPDLVPDPN YVQASTYVQR AHLYSLRCAA EEKCLASTAY APEATDYDLR 450
    VLLRFPQRVK NQGTADFLPN RPRHTWEWHS CHQHYHSMDE FSHYDLLDAS 500
    TGKKVAEGHK ASFCLEDSTC DFGNLKRYAC TSHTQGLSPG CYDTYNADID 550
    CQWIDITDVQ PGNYILKVHV NPKYIVLESD FTNNVVRCNI HYTGRYVSTT 600
    NCKIVQS 607
    Length:607
    Mass (Da):66,506
    Last modified:September 19, 2003 - v3
    Checksum:i7BA8144F09E96C94
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti173 – 1731P → S in AAH37999. (PubMed:15489334)Curated
    Sequence conflicti208 – 2103GAG → HAS in AAH03973. (PubMed:15489334)Curated
    Sequence conflicti321 – 3211T → I in AAH03973. (PubMed:15489334)Curated
    Sequence conflicti500 – 5001S → A in AAB86802. (PubMed:9250877)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF357006 mRNA. Translation: AAK97375.1.
    BC003973 mRNA. Translation: AAH03973.1.
    BC037999 mRNA. Translation: AAH37999.1.
    AH006767 Genomic DNA. Translation: AAC53067.1.
    U79144 mRNA. Translation: AAB86802.1.
    CCDSiCCDS52813.1.
    RefSeqiNP_034859.2. NM_010729.3.
    UniGeneiMm.250492.

    Genome annotation databases

    EnsembliENSMUST00000061799; ENSMUSP00000057406; ENSMUSG00000032334.
    GeneIDi16949.
    KEGGimmu:16949.
    UCSCiuc009pwv.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF357006 mRNA. Translation: AAK97375.1 .
    BC003973 mRNA. Translation: AAH03973.1 .
    BC037999 mRNA. Translation: AAH37999.1 .
    AH006767 Genomic DNA. Translation: AAC53067.1 .
    U79144 mRNA. Translation: AAB86802.1 .
    CCDSi CCDS52813.1.
    RefSeqi NP_034859.2. NM_010729.3.
    UniGenei Mm.250492.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 201192. 1 interaction.
    IntActi P97873. 2 interactions.
    MINTi MINT-6743519.

    PTM databases

    PhosphoSitei P97873.

    Proteomic databases

    PaxDbi P97873.
    PRIDEi P97873.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000061799 ; ENSMUSP00000057406 ; ENSMUSG00000032334 .
    GeneIDi 16949.
    KEGGi mmu:16949.
    UCSCi uc009pwv.2. mouse.

    Organism-specific databases

    CTDi 4016.
    MGIi MGI:106096. Loxl1.

    Phylogenomic databases

    eggNOGi NOG77510.
    GeneTreei ENSGT00740000115025.
    HOGENOMi HOG000234262.
    HOVERGENi HBG000226.
    InParanoidi P97873.
    KOi K14678.
    OrthoDBi EOG7SN8C6.
    PhylomeDBi P97873.
    TreeFami TF326061.

    Enzyme and pathway databases

    Reactomei REACT_196515. Crosslinking of collagen fibrils.
    REACT_198996. Elastic fibre formation.

    Miscellaneous databases

    NextBioi 290996.
    PROi P97873.
    SOURCEi Search...

    Gene expression databases

    Bgeei P97873.
    CleanExi MM_LOXL1.
    Genevestigatori P97873.

    Family and domain databases

    InterProi IPR001695. Lysyl_oxidase.
    IPR019828. Lysyl_oxidase_CS.
    [Graphical view ]
    Pfami PF01186. Lysyl_oxidase. 1 hit.
    [Graphical view ]
    PRINTSi PR00074. LYSYLOXIDASE.
    PROSITEi PS00926. LYSYL_OXIDASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of the recombinant and natural forms of mature lysyl oxidase-like 1."
      Seve S., Borel A., Gleyzal C., Farjanel J., Eichenberger D., Font B., Sommer P.
      Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Mammary gland.
    3. "Genetic mapping of lysyl oxidase-2 (Loxl) on mouse chromosome 9."
      Tchernev V.T., Yang T.P., Kingsmore S.F.
      Mamm. Genome 8:621-622(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 498-607.
    4. "An intron capture strategy used to identify and map a lysyl oxidase-like gene on chromosome 9 in the mouse."
      Wydner K.S., Kim Y., Csiszar K., Boyd C.D., Passmore H.C.
      Genomics 40:342-345(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 526-540.
      Strain: C57BL/6J.

    Entry informationi

    Entry nameiLOXL1_MOUSE
    AccessioniPrimary (citable) accession number: P97873
    Secondary accession number(s): Q91ZY4, Q99KX3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: September 19, 2003
    Last modified: October 1, 2014
    This is version 106 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3