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Protein

Lysyl oxidase homolog 1

Gene

Loxl1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Active on elastin and collagen substrates.By similarity

Cofactori

Protein has several cofactor binding sites:

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi482 – 4821CopperSequence Analysis
Metal bindingi484 – 4841CopperSequence Analysis
Metal bindingi486 – 4861CopperSequence Analysis

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Copper, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_299762. Crosslinking of collagen fibrils.
REACT_334317. Elastic fibre formation.

Names & Taxonomyi

Protein namesi
Recommended name:
Lysyl oxidase homolog 1 (EC:1.4.3.-)
Alternative name(s):
Lysyl oxidase 2
Lysyl oxidase-like protein 1
Gene namesi
Name:Loxl1
Synonyms:Lox2, Loxl
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:106096. Loxl1.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: UniProtKB-SubCell
  • proteinaceous extracellular matrix Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828Sequence AnalysisAdd
BLAST
Propeptidei29 – 9466By similarityPRO_0000018530Add
BLAST
Chaini95 – 607513Lysyl oxidase homolog 1PRO_0000018531Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi428 ↔ 434By similarity
Disulfide bondi481 ↔ 530By similarity
Cross-linki510 ↔ 545Lysine tyrosylquinone (Lys-Tyr)By similarity
Disulfide bondi514 ↔ 520By similarity
Disulfide bondi541 ↔ 551By similarity
Modified residuei545 – 54512',4',5'-topaquinoneBy similarity
Disulfide bondi588 ↔ 602By similarity

Post-translational modificationi

The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, LTQ, TPQ

Proteomic databases

MaxQBiP97873.
PaxDbiP97873.
PRIDEiP97873.

PTM databases

PhosphoSiteiP97873.

Expressioni

Gene expression databases

BgeeiP97873.
CleanExiMM_LOXL1.
GenevisibleiP97873. MM.

Interactioni

Protein-protein interaction databases

BioGridi201192. 1 interaction.
IntActiP97873. 2 interactions.
MINTiMINT-6743519.
STRINGi10090.ENSMUSP00000057406.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni403 – 607205Lysyl-oxidase likeAdd
BLAST

Sequence similaritiesi

Belongs to the lysyl oxidase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG77510.
HOGENOMiHOG000234262.
HOVERGENiHBG000226.
InParanoidiP97873.
KOiK14678.
OrthoDBiEOG7SN8C6.
PhylomeDBiP97873.
TreeFamiTF326061.

Family and domain databases

InterProiIPR001695. Lysyl_oxidase.
IPR019828. Lysyl_oxidase_CS.
[Graphical view]
PfamiPF01186. Lysyl_oxidase. 1 hit.
[Graphical view]
PRINTSiPR00074. LYSYLOXIDASE.
PROSITEiPS00926. LYSYL_OXIDASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P97873-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALAGAGSQL RTLVWSACLC VLVHGQQAQP GQGSDPGRWR QLIQWENNGQ
60 70 80 90 100
VYSLLNSGSE YVPAGPQRGE TSSRVLLAGA PQTSQRRSQG GPRRRQAPSL
110 120 130 140 150
PLPGRVGSDT VRGQTRHPFG FGQVPDNWRE VAVGDSTGMA RARTSVSQQR
160 170 180 190 200
HGGSASSSVS ASAFATTYRQ PSPYPQQFPY PQAPFVNQYE NYDPASRTYE
210 220 230 240 250
QGYVYYRGAG GGMGAGAAAV ASAGVIYPFQ PRARYEDYGG GGGEEQPEYP
260 270 280 290 300
AQGFYPAPER PYVPQPQPQP QPQPQPQPQP SDGLDRRYSH SLYNEGTPGF
310 320 330 340 350
EQAYPDPSTD VSQAPAGAGG TYGGAGDPRL GWYPPYAANV PPEAYVPPRA
360 370 380 390 400
VEPQPPFRVL EPPYLPVRSS DAPSQGGERN GAQQGRLSVG SVYRPNQNGR
410 420 430 440 450
GLPDLVPDPN YVQASTYVQR AHLYSLRCAA EEKCLASTAY APEATDYDLR
460 470 480 490 500
VLLRFPQRVK NQGTADFLPN RPRHTWEWHS CHQHYHSMDE FSHYDLLDAS
510 520 530 540 550
TGKKVAEGHK ASFCLEDSTC DFGNLKRYAC TSHTQGLSPG CYDTYNADID
560 570 580 590 600
CQWIDITDVQ PGNYILKVHV NPKYIVLESD FTNNVVRCNI HYTGRYVSTT

NCKIVQS
Length:607
Mass (Da):66,506
Last modified:September 19, 2003 - v3
Checksum:i7BA8144F09E96C94
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti173 – 1731P → S in AAH37999 (PubMed:15489334).Curated
Sequence conflicti208 – 2103GAG → HAS in AAH03973 (PubMed:15489334).Curated
Sequence conflicti321 – 3211T → I in AAH03973 (PubMed:15489334).Curated
Sequence conflicti500 – 5001S → A in AAB86802 (PubMed:9250877).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF357006 mRNA. Translation: AAK97375.1.
BC003973 mRNA. Translation: AAH03973.1.
BC037999 mRNA. Translation: AAH37999.1.
AH006767 Genomic DNA. Translation: AAC53067.1.
U79144 mRNA. Translation: AAB86802.1.
CCDSiCCDS52813.1.
RefSeqiNP_034859.2. NM_010729.3.
UniGeneiMm.250492.

Genome annotation databases

GeneIDi16949.
KEGGimmu:16949.
UCSCiuc009pwv.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF357006 mRNA. Translation: AAK97375.1.
BC003973 mRNA. Translation: AAH03973.1.
BC037999 mRNA. Translation: AAH37999.1.
AH006767 Genomic DNA. Translation: AAC53067.1.
U79144 mRNA. Translation: AAB86802.1.
CCDSiCCDS52813.1.
RefSeqiNP_034859.2. NM_010729.3.
UniGeneiMm.250492.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201192. 1 interaction.
IntActiP97873. 2 interactions.
MINTiMINT-6743519.
STRINGi10090.ENSMUSP00000057406.

PTM databases

PhosphoSiteiP97873.

Proteomic databases

MaxQBiP97873.
PaxDbiP97873.
PRIDEiP97873.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi16949.
KEGGimmu:16949.
UCSCiuc009pwv.2. mouse.

Organism-specific databases

CTDi4016.
MGIiMGI:106096. Loxl1.

Phylogenomic databases

eggNOGiNOG77510.
HOGENOMiHOG000234262.
HOVERGENiHBG000226.
InParanoidiP97873.
KOiK14678.
OrthoDBiEOG7SN8C6.
PhylomeDBiP97873.
TreeFamiTF326061.

Enzyme and pathway databases

ReactomeiREACT_299762. Crosslinking of collagen fibrils.
REACT_334317. Elastic fibre formation.

Miscellaneous databases

NextBioi290996.
PROiP97873.
SOURCEiSearch...

Gene expression databases

BgeeiP97873.
CleanExiMM_LOXL1.
GenevisibleiP97873. MM.

Family and domain databases

InterProiIPR001695. Lysyl_oxidase.
IPR019828. Lysyl_oxidase_CS.
[Graphical view]
PfamiPF01186. Lysyl_oxidase. 1 hit.
[Graphical view]
PRINTSiPR00074. LYSYLOXIDASE.
PROSITEiPS00926. LYSYL_OXIDASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of the recombinant and natural forms of mature lysyl oxidase-like 1."
    Seve S., Borel A., Gleyzal C., Farjanel J., Eichenberger D., Font B., Sommer P.
    Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Mammary gland.
  3. "Genetic mapping of lysyl oxidase-2 (Loxl) on mouse chromosome 9."
    Tchernev V.T., Yang T.P., Kingsmore S.F.
    Mamm. Genome 8:621-622(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 498-607.
  4. "An intron capture strategy used to identify and map a lysyl oxidase-like gene on chromosome 9 in the mouse."
    Wydner K.S., Kim Y., Csiszar K., Boyd C.D., Passmore H.C.
    Genomics 40:342-345(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 526-540.
    Strain: C57BL/6J.

Entry informationi

Entry nameiLOXL1_MOUSE
AccessioniPrimary (citable) accession number: P97873
Secondary accession number(s): Q91ZY4, Q99KX3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: September 19, 2003
Last modified: July 22, 2015
This is version 115 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.