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Protein

Dimethylaniline monooxygenase [N-oxide-forming] 5

Gene

Fmo5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

In contrast with other forms of FMO it does not seem to be a drug-metabolizing enzyme.By similarity

Catalytic activityi

N,N-dimethylaniline + NADPH + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O.

Cofactori

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 156FADSequence analysis
Nucleotide bindingi192 – 1976NADPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein, NADP

Enzyme and pathway databases

BRENDAi1.14.13.8. 3474.

Names & Taxonomyi

Protein namesi
Recommended name:
Dimethylaniline monooxygenase [N-oxide-forming] 5 (EC:1.14.13.8)
Alternative name(s):
Dimethylaniline oxidase 5
Hepatic flavin-containing monooxygenase 5
Short name:
FMO 5
Gene namesi
Name:Fmo5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1310004. Fmo5.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 533533Dimethylaniline monooxygenase [N-oxide-forming] 5PRO_0000147666Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei5 – 51Dimethylated arginine; alternateBy similarity
Modified residuei5 – 51Omega-N-methylated arginine; alternateBy similarity
Modified residuei54 – 541PhosphoserineBy similarity
Modified residuei56 – 561PhosphotyrosineBy similarity
Modified residuei58 – 581PhosphoserineBy similarity
Modified residuei280 – 2801PhosphoserineBy similarity
Modified residuei284 – 2841PhosphothreonineBy similarity
Modified residuei401 – 4011PhosphoserineCombined sources

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

MaxQBiP97872.
PaxDbiP97872.
PeptideAtlasiP97872.
PRIDEiP97872.

PTM databases

iPTMnetiP97872.
PhosphoSiteiP97872.
SwissPalmiP97872.

Expressioni

Gene expression databases

BgeeiENSMUSG00000028088.
CleanExiMM_FMO5.
GenevisibleiP97872. MM.

Interactioni

Protein-protein interaction databases

IntActiP97872. 8 interactions.
MINTiMINT-1858630.
STRINGi10090.ENSMUSP00000029729.

Structurei

3D structure databases

ProteinModelPortaliP97872.
SMRiP97872. Positions 5-441.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FMO family.Curated

Keywords - Domaini

Transmembrane

Phylogenomic databases

eggNOGiKOG1399. Eukaryota.
COG2072. LUCA.
GeneTreeiENSGT00760000119232.
HOGENOMiHOG000076537.
HOVERGENiHBG002037.
InParanoidiP97872.
KOiK00485.
OMAiWHRINAG.
OrthoDBiEOG091G0465.
TreeFamiTF105285.

Family and domain databases

Gene3Di3.40.50.720. 2 hits.
3.50.50.60. 2 hits.
InterProiIPR012143. DiMe-aniline_mOase.
IPR023753. FAD/NAD-binding_dom.
IPR000960. Flavin_mOase.
IPR020946. Flavin_mOase-like.
IPR002257. Flavin_mOase_5.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00743. FMO-like. 1 hit.
[Graphical view]
PIRSFiPIRSF000332. FMO. 1 hit.
PRINTSiPR00370. FMOXYGENASE.
PR01125. FMOXYGENASE5.
SUPFAMiSSF51905. SSF51905. 2 hits.

Sequencei

Sequence statusi: Complete.

P97872-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKKRIAVIG AGASGLTCIK CCLEEGLEPV CFERSGDIGG LWRFQEAPEE
60 70 80 90 100
GRASIYQSVV INTSKEMMCF SDYPIPDHYP NYMHNSQVLE YFRMYAKEFD
110 120 130 140 150
LLKYIQFKTT VCSVKKQPDF STSGQWQVVT ECEGKQQVDV FDGVLVCTGH
160 170 180 190 200
HTDAHLPLES FPGIEKFKGK YFHSRDYKNP VEFTGKRVIV IGIGNSGGDL
210 220 230 240 250
AVEISHTAKQ VFLSTRRGAW ILNRVGKHGY PIDLLLSSRI MYYLSRICGP
260 270 280 290 300
SLKNNYMEKQ MNQRFDHEMF GLKPKHRALS QHPTVNDDLP NRIIAGLVKV
310 320 330 340 350
KGNVKEFTET AAVFEDGSRE DGIDVVIFAT GYSFAFPFLE DSVKVVKNKV
360 370 380 390 400
SLYKKVFPPN LEKPTLAIIG LIQPLGAIMP ISELQGRWAT QVFKGLKKLP
410 420 430 440 450
SQSEMMAEIN KAREEMAKRY VDSQRHTIQG DYIDTMEEIA DLVGVRPNIL
460 470 480 490 500
PLVFTDPRLA LRLLLGPCTP VQYRLQGPGK WAGARKTILT TEDRVRKPLM
510 520 530
TRVVERDSSG GSLVTVRVLM LAVAFFAVIL AYF
Length:533
Mass (Da):60,001
Last modified:July 27, 2011 - v4
Checksum:i4B9B246C4D7EBE34
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti313 – 3131V → I in AAB50013 (PubMed:9580872).Curated
Sequence conflicti450 – 4501L → Q in AAB50013 (PubMed:9580872).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U90535 mRNA. Translation: AAB50013.1.
AK133675 mRNA. Translation: BAE21778.1.
CH466620 Genomic DNA. Translation: EDL38939.1.
BC022991 mRNA. Translation: AAH22991.1.
CCDSiCCDS17656.1.
RefSeqiNP_001155235.1. NM_001161763.1.
NP_001155237.1. NM_001161765.1.
NP_034362.2. NM_010232.4.
XP_006501058.1. XM_006500995.2.
UniGeneiMm.385180.

Genome annotation databases

EnsembliENSMUST00000029729; ENSMUSP00000029729; ENSMUSG00000028088.
ENSMUST00000107049; ENSMUSP00000102664; ENSMUSG00000028088.
ENSMUST00000107050; ENSMUSP00000102665; ENSMUSG00000028088.
GeneIDi14263.
KEGGimmu:14263.
UCSCiuc008qoy.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U90535 mRNA. Translation: AAB50013.1.
AK133675 mRNA. Translation: BAE21778.1.
CH466620 Genomic DNA. Translation: EDL38939.1.
BC022991 mRNA. Translation: AAH22991.1.
CCDSiCCDS17656.1.
RefSeqiNP_001155235.1. NM_001161763.1.
NP_001155237.1. NM_001161765.1.
NP_034362.2. NM_010232.4.
XP_006501058.1. XM_006500995.2.
UniGeneiMm.385180.

3D structure databases

ProteinModelPortaliP97872.
SMRiP97872. Positions 5-441.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP97872. 8 interactions.
MINTiMINT-1858630.
STRINGi10090.ENSMUSP00000029729.

PTM databases

iPTMnetiP97872.
PhosphoSiteiP97872.
SwissPalmiP97872.

Proteomic databases

MaxQBiP97872.
PaxDbiP97872.
PeptideAtlasiP97872.
PRIDEiP97872.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029729; ENSMUSP00000029729; ENSMUSG00000028088.
ENSMUST00000107049; ENSMUSP00000102664; ENSMUSG00000028088.
ENSMUST00000107050; ENSMUSP00000102665; ENSMUSG00000028088.
GeneIDi14263.
KEGGimmu:14263.
UCSCiuc008qoy.2. mouse.

Organism-specific databases

CTDi2330.
MGIiMGI:1310004. Fmo5.

Phylogenomic databases

eggNOGiKOG1399. Eukaryota.
COG2072. LUCA.
GeneTreeiENSGT00760000119232.
HOGENOMiHOG000076537.
HOVERGENiHBG002037.
InParanoidiP97872.
KOiK00485.
OMAiWHRINAG.
OrthoDBiEOG091G0465.
TreeFamiTF105285.

Enzyme and pathway databases

BRENDAi1.14.13.8. 3474.

Miscellaneous databases

ChiTaRSiFmo5. mouse.
PROiP97872.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028088.
CleanExiMM_FMO5.
GenevisibleiP97872. MM.

Family and domain databases

Gene3Di3.40.50.720. 2 hits.
3.50.50.60. 2 hits.
InterProiIPR012143. DiMe-aniline_mOase.
IPR023753. FAD/NAD-binding_dom.
IPR000960. Flavin_mOase.
IPR020946. Flavin_mOase-like.
IPR002257. Flavin_mOase_5.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00743. FMO-like. 1 hit.
[Graphical view]
PIRSFiPIRSF000332. FMO. 1 hit.
PRINTSiPR00370. FMOXYGENASE.
PR01125. FMOXYGENASE5.
SUPFAMiSSF51905. SSF51905. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiFMO5_MOUSE
AccessioniPrimary (citable) accession number: P97872
Secondary accession number(s): Q8R1W6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 27, 2011
Last modified: September 7, 2016
This is version 128 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.