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P97868

- RBBP6_MOUSE

UniProt

P97868 - RBBP6_MOUSE

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Protein

E3 ubiquitin-protein ligase RBBP6

Gene

Rbbp6

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome By similarity. May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth retardation.By similarity1 Publication

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri160 – 17718CCHC-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri260 – 30142RING-type; degeneratePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. ligase activity Source: UniProtKB-KW
  2. poly(A) RNA binding Source: Ensembl
  3. ubiquitin-protein transferase activity Source: UniProtKB
  4. zinc ion binding Source: InterPro

GO - Biological processi

  1. embryonic organ development Source: MGI
  2. in utero embryonic development Source: MGI
  3. multicellular organism growth Source: MGI
  4. protein ubiquitination involved in ubiquitin-dependent protein catabolic process Source: UniProtKB
  5. somite development Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase RBBP6 (EC:6.3.2.-)
Alternative name(s):
Proliferation potential-related protein
Protein P2P-R
Retinoblastoma-binding protein 6
p53-associated cellular protein of testis
Gene namesi
Name:Rbbp6
Synonyms:P2pr, Pact
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:894835. Rbbp6.

Subcellular locationi

Nucleusnucleolus. Chromosome. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome By similarity
Note: Colocalizes with mitotic chromosomes. Co-localizes with NEK6 in the centrosome By similarity.By similarity

GO - Cellular componenti

  1. chromosome Source: UniProtKB-KW
  2. cytoplasm Source: UniProtKB-KW
  3. cytoskeleton Source: UniProtKB-KW
  4. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechi

Disruption phenotypei

Early embryonic lethality before E7.5, accompanied by accumulation of p53 and widespread apoptosis.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 17901790E3 ubiquitin-protein ligase RBBP6PRO_0000234355Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei130 – 1301N6-acetyllysine1 Publication
Modified residuei245 – 2451PhosphoserineBy similarity
Modified residuei246 – 2461PhosphoserineBy similarity
Modified residuei247 – 2471PhosphoserineBy similarity
Modified residuei248 – 2481PhosphoserineBy similarity
Modified residuei361 – 3611PhosphoserineBy similarity
Modified residuei517 – 5171PhosphoserineBy similarity
Modified residuei771 – 7711PhosphoserineBy similarity
Modified residuei773 – 7731PhosphoserineBy similarity
Modified residuei781 – 7811PhosphoserineBy similarity
Modified residuei862 – 8621PhosphoserineBy similarity
Modified residuei985 – 9851Phosphothreonine1 Publication
Modified residuei1179 – 11791Phosphoserine2 Publications
Modified residuei1272 – 12721Phosphothreonine1 Publication
Modified residuei1278 – 12781PhosphoserineBy similarity
Modified residuei1329 – 13291Phosphoserine2 Publications
Modified residuei1469 – 14691PhosphothreonineBy similarity
Modified residuei1646 – 16461PhosphoserineBy similarity
Modified residuei1648 – 16481PhosphoserineBy similarity

Post-translational modificationi

Phosphorylated by NEK6.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP97868.
PaxDbiP97868.
PRIDEiP97868.

PTM databases

PhosphoSiteiP97868.

Expressioni

Tissue specificityi

Highly expressed in testis. Expressed at lower levels in brain, heart, kidney, liver, lung, skeletal muscle, spleen, thymus and tongue.2 Publications

Developmental stagei

Expression is reduced during terminal differentiation. Expression is induced in the G2/M phase of the cell cycle (at protein level).2 Publications

Gene expression databases

BgeeiP97868.
CleanExiMM_RBBP6.
ExpressionAtlasiP97868. baseline and differential.
GenevestigatoriP97868.

Interactioni

Subunit structurei

Interacts with MDM2 and YBX1 By similarity. Interacts also with p53/TP53 and RB1. Interacts with NEK6 By similarity.By similarity

Protein-protein interaction databases

BioGridi202817. 1 interaction.
IntActiP97868. 1 interaction.
MINTiMINT-4106375.
STRINGi10090.ENSMUSP00000049528.

Structurei

3D structure databases

ProteinModelPortaliP97868.
SMRiP97868. Positions 1-81, 160-207, 250-336.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 7673DWNNPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni983 – 1139157Interaction with RB1Add
BLAST
Regioni1434 – 1544111Interaction with p53Add
BLAST

Sequence similaritiesi

Contains 1 CCHC-type zinc finger.PROSITE-ProRule annotation
Contains 1 DWNN domain.PROSITE-ProRule annotation
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri160 – 17718CCHC-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri260 – 30142RING-type; degeneratePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiCOG5222.
GeneTreeiENSGT00610000086096.
HOVERGENiHBG093889.
InParanoidiP97868.
KOiK10624.
OMAiEREYFNR.
OrthoDBiEOG74BJR8.
PhylomeDBiP97868.
TreeFamiTF350543.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
4.10.60.10. 1 hit.
InterProiIPR014891. DWNN_domain.
IPR001878. Znf_CCHC.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF08783. DWNN. 1 hit.
PF00098. zf-CCHC. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
SM00343. ZnF_C2HC. 1 hit.
[Graphical view]
SUPFAMiSSF57756. SSF57756. 1 hit.
PROSITEiPS51282. DWNN. 1 hit.
PS50158. ZF_CCHC. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P97868-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSCVHYKFSS KLNYDTVTFD GLHISLCDLK KQIMGREKLK AADSDLQITN
60 70 80 90 100
AQTKEEYTDD NALIPKNSSV IVRRIPIGGV KSTSKTYVIS RTEPVMGTTK
110 120 130 140 150
AIDDASASIS LAQLTKTANL AEANASEEDK IKAMMSQSGH EYDPINYMKK
160 170 180 190 200
TLVGPPPPSY TCFRCGKPGH YIKNCPTNGD KNFESGPRIK KSTGIPRSFM
210 220 230 240 250
MEVKDPNMKG AMLTNTGKYA IPTIDAEAYA IGKKEKPPFL PEEPSSSSEE
260 270 280 290 300
DDPIPDELLC LICKDIMTDA VVIPCCGNSY CDECIRTALL ESDEHTCPTC
310 320 330 340 350
HQNDVSPDAL IANKFLRQAV NNFKNETGYT KRLRKQLPPP PPPVPPPRPL
360 370 380 390 400
MQRNLQPLMR SPISRQQDPL MIPVTSSSAH SAPSISSLTS NPSALAPSVS
410 420 430 440 450
GNPSSAPAPV PDITATVSIS VHSEKSDGPF RDSDNKLLPA AALTSEHSKG
460 470 480 490 500
ASSIAITALM EEKGYQVPVL GTPSLLGQSL LHGQLIPTTG PVRINAARPG
510 520 530 540 550
GGRPGWEHSN KLGYLVSPPQ QIRRGERSCY RSINRGRHHS ERSQRTQGPS
560 570 580 590 600
LPATPVFVPV PPPPLYPPPP HTLPLPPGVP PPQFSPQFPP GQPPPAGYSV
610 620 630 640 650
PPPGFPPAPA NISTPWVSSG VQTAHSNTIP TTQAPPLSRE EFYREQRRLK
660 670 680 690 700
EEEKKKSKLD EFTNDFAKEL MEYKKIQKER RRSFSRSKSP YSGSSYSRSS
710 720 730 740 750
YTYSKSRSGS TRSRSYSRSF SRSHSRSYSR SPPYPRRGRG KSRNYRSRSR
760 770 780 790 800
SHGYHRSRSR SPPYRRYHSR SRSPQAFRGQ SPTKRNVPQG ETEREYFNRY
810 820 830 840 850
REVPPPYDIK AYYGRSVDFR DPFEKERYRE WERKYREWYE KYYKGYAVGA
860 870 880 890 900
QPRPSANRED FSPERLLPLN IRNSPFTRGR REDYAAGQSH RNRNLGGNYP
910 920 930 940 950
EKLSTRDSHN AKDNPKSKEK ESENVPGDGK GNKHKKHRKR RKGEESESFL
960 970 980 990 1000
NPELLETSRK CRESSGIDET KTDTLFVLPS RDDATPVRDE PMDAESITFK
1010 1020 1030 1040 1050
SVSDKDKREK DKPKVKSDKT KRKSDGSATA KKDNVLKPSK GPQEKVDGDR
1060 1070 1080 1090 1100
EKSPRSEPPL KKAKEEATKI DSVKPSSSSQ KDEKVTGTPR KAHSKSAKEH
1110 1120 1130 1140 1150
QEAKPAKDEK VKKDCSKDIK SEKPASKDEK AKKPEKNKLL DSKGEKRKRK
1160 1170 1180 1190 1200
TEEKSVDKDF ESSSMKISKV EGTEIVKPSP KRKMEGDVEK LERTPEKDKI
1210 1220 1230 1240 1250
ASSTTPAKKI KLNRETGKKI GNAENASTTK EPSEKLESTS SKIKQEKVKG
1260 1270 1280 1290 1300
KAKRKVAGSE GSSSTLVDYT STSSTGGSPV RKSEEKTDTK RTVIKTMEEY
1310 1320 1330 1340 1350
NNDNTAPAED VIIMIQVPQS KWDKDDFESE EEDVKTTQPI QSVGKPSSII
1360 1370 1380 1390 1400
KNVTTKPSAT AKYTEKESEQ PEKLQKLPKE ASHELMQHEL RSSKGSASSE
1410 1420 1430 1440 1450
KGRAKDREHS GSEKDNPDKR KSGAQPDKES TVDRLSEQGH FKTLSQSSKE
1460 1470 1480 1490 1500
TRTSEKHESV RGSSNKDFTP GRDKKVDYDS RDYSSSKRRD ERGELARRKD
1510 1520 1530 1540 1550
SPPRGKESLS GQKSKLREER DLPKKGAESK KSNSSPPRDK KPHDHKAPYE
1560 1570 1580 1590 1600
TKRPCEETKP VDKNSGKERE KHAAEARNGK ESSGGKLPCI PNPPDPPMEK
1610 1620 1630 1640 1650
ELAAGQVEKS AVKPKPQLSH SSRLSSDLTR ETDEAAFEPD YNESDSESNV
1660 1670 1680 1690 1700
SVKEEEAVAS ISKDLKEKTT EKAKESLTVA TASQPGADRS QSQSSPSVSP
1710 1720 1730 1740 1750
SRSHSPSGSQ TRSHSSSASS AGSQDSKKKK KKKEKKKHKK HKKHKKHKKH
1760 1770 1780 1790
AGADGDVEKS QKHKHKKKKA KKNKDKEKEK DDQKVRSVTV
Length:1,790
Mass (Da):199,587
Last modified:May 16, 2006 - v5
Checksum:i3909C30EB9DD2CE3
GO
Isoform 2 (identifier: P97868-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     653-686: Missing.

Show »
Length:1,756
Mass (Da):195,310
Checksum:iE3C0F009CC28107E
GO
Isoform 3 (identifier: P97868-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     102-123: IDDASASISLAQLTKTANLAEA → VCKNTITLFLHNCFYLYNVSVT
     124-1756: Missing.

Show »
Length:157
Mass (Da):17,888
Checksum:i39B749141C9B2FA6
GO

Sequence cautioni

The sequence AAC72432.1 differs from that shown. Reason: Frameshift at position 176.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti254 – 2541I → F in AAB49620. (PubMed:9010216)Curated
Sequence conflicti317 – 3182RQ → GR in AAC72432. (PubMed:9037032)Curated
Sequence conflicti341 – 3411P → H in AAB49620. (PubMed:9010216)Curated
Sequence conflicti418 – 4181S → F in AAC72432. (PubMed:9037032)Curated
Sequence conflicti421 – 4211V → S in AAB49620. (PubMed:9010216)Curated
Sequence conflicti580 – 5801P → L in AAC72432. (PubMed:9037032)Curated
Sequence conflicti595 – 5951P → T in AAC72432. (PubMed:9037032)Curated
Sequence conflicti615 – 6228PWVSSGVQ → ACFSPGVP in AAC72432. (PubMed:9037032)Curated
Sequence conflicti629 – 6291I → M in AAC72432. (PubMed:9037032)Curated
Sequence conflicti636 – 6361P → L in AAC72432. (PubMed:9037032)Curated
Sequence conflicti647 – 6471R → K in AAC72432. (PubMed:9037032)Curated
Sequence conflicti689 – 6891S → F in AAC72432. (PubMed:9037032)Curated
Sequence conflicti703 – 7031Y → D in AAC72432. (PubMed:9037032)Curated
Sequence conflicti789 – 7891Q → R in AAC72432. (PubMed:9037032)Curated
Sequence conflicti940 – 9401R → Q in BAE36255. (PubMed:16141072)Curated
Sequence conflicti941 – 9411R → RNEE in AAC72432. (PubMed:9037032)Curated
Sequence conflicti956 – 9583ETS → GKF in AAC72432. (PubMed:9037032)Curated
Sequence conflicti963 – 9631E → G in AAC72432. (PubMed:9037032)Curated
Sequence conflicti978 – 9781L → F in AAC72432. (PubMed:9037032)Curated
Sequence conflicti982 – 9821D → E in AAC72432. (PubMed:9037032)Curated
Sequence conflicti1012 – 10121K → N in AAB49620. (PubMed:9010216)Curated
Sequence conflicti1290 – 12901K → T in AAC72432. (PubMed:9037032)Curated
Sequence conflicti1316 – 13161Q → H in AAC72432. (PubMed:9037032)Curated
Sequence conflicti1564 – 15641N → I in AAC72432. (PubMed:9037032)Curated
Sequence conflicti1581 – 15811E → D in AAC72432. (PubMed:9037032)Curated
Sequence conflicti1591 – 15911P → L in AAC72432. (PubMed:9037032)Curated
Sequence conflicti1596 – 15961P → L in AAC72432. (PubMed:9037032)Curated
Sequence conflicti1604 – 16041A → V in AAC72432. (PubMed:9037032)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei102 – 12322IDDAS…NLAEA → VCKNTITLFLHNCFYLYNVS VT in isoform 3. 2 PublicationsVSP_018285Add
BLAST
Alternative sequencei124 – 17561633Missing in isoform 3. 2 PublicationsVSP_018286Add
BLAST
Alternative sequencei653 – 68634Missing in isoform 2. 2 PublicationsVSP_018287Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK045635 mRNA. Translation: BAC32441.1.
AK079129 mRNA. Translation: BAC37553.1.
AK081261 mRNA. Translation: BAC38179.1.
AK144758 mRNA. Translation: BAE26051.1.
AK160656 mRNA. Translation: BAE35944.1.
AK161231 mRNA. Translation: BAE36255.1.
AC125221 Genomic DNA. No translation available.
BC025874 mRNA. Translation: AAH25874.1.
U83913 mRNA. Translation: AAC72432.1. Frameshift.
U28789 mRNA. Translation: AAB49620.1.
CCDSiCCDS52387.1. [P97868-1]
PIRiT42727.
RefSeqiNP_035377.2. NM_011247.2. [P97868-1]
NP_778188.1. NM_175023.3.
XP_006507533.1. XM_006507470.1. [P97868-2]
UniGeneiMm.4480.

Genome annotation databases

EnsembliENSMUST00000052135; ENSMUSP00000049528; ENSMUSG00000030779. [P97868-1]
ENSMUST00000071590; ENSMUSP00000071519; ENSMUSG00000030779. [P97868-2]
ENSMUST00000098062; ENSMUSP00000095670; ENSMUSG00000030779.
GeneIDi19647.
KEGGimmu:19647.
UCSCiuc009jow.2. mouse. [P97868-3]
uc009joy.2. mouse. [P97868-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK045635 mRNA. Translation: BAC32441.1 .
AK079129 mRNA. Translation: BAC37553.1 .
AK081261 mRNA. Translation: BAC38179.1 .
AK144758 mRNA. Translation: BAE26051.1 .
AK160656 mRNA. Translation: BAE35944.1 .
AK161231 mRNA. Translation: BAE36255.1 .
AC125221 Genomic DNA. No translation available.
BC025874 mRNA. Translation: AAH25874.1 .
U83913 mRNA. Translation: AAC72432.1 . Frameshift.
U28789 mRNA. Translation: AAB49620.1 .
CCDSi CCDS52387.1. [P97868-1 ]
PIRi T42727.
RefSeqi NP_035377.2. NM_011247.2. [P97868-1 ]
NP_778188.1. NM_175023.3.
XP_006507533.1. XM_006507470.1. [P97868-2 ]
UniGenei Mm.4480.

3D structure databases

ProteinModelPortali P97868.
SMRi P97868. Positions 1-81, 160-207, 250-336.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 202817. 1 interaction.
IntActi P97868. 1 interaction.
MINTi MINT-4106375.
STRINGi 10090.ENSMUSP00000049528.

PTM databases

PhosphoSitei P97868.

Proteomic databases

MaxQBi P97868.
PaxDbi P97868.
PRIDEi P97868.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000052135 ; ENSMUSP00000049528 ; ENSMUSG00000030779 . [P97868-1 ]
ENSMUST00000071590 ; ENSMUSP00000071519 ; ENSMUSG00000030779 . [P97868-2 ]
ENSMUST00000098062 ; ENSMUSP00000095670 ; ENSMUSG00000030779 .
GeneIDi 19647.
KEGGi mmu:19647.
UCSCi uc009jow.2. mouse. [P97868-3 ]
uc009joy.2. mouse. [P97868-1 ]

Organism-specific databases

CTDi 5930.
MGIi MGI:894835. Rbbp6.

Phylogenomic databases

eggNOGi COG5222.
GeneTreei ENSGT00610000086096.
HOVERGENi HBG093889.
InParanoidi P97868.
KOi K10624.
OMAi EREYFNR.
OrthoDBi EOG74BJR8.
PhylomeDBi P97868.
TreeFami TF350543.

Enzyme and pathway databases

UniPathwayi UPA00143 .

Miscellaneous databases

ChiTaRSi RBBP6. mouse.
NextBioi 296898.
PROi P97868.
SOURCEi Search...

Gene expression databases

Bgeei P97868.
CleanExi MM_RBBP6.
ExpressionAtlasi P97868. baseline and differential.
Genevestigatori P97868.

Family and domain databases

Gene3Di 3.30.40.10. 1 hit.
4.10.60.10. 1 hit.
InterProi IPR014891. DWNN_domain.
IPR001878. Znf_CCHC.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view ]
Pfami PF08783. DWNN. 1 hit.
PF00098. zf-CCHC. 1 hit.
[Graphical view ]
SMARTi SM00184. RING. 1 hit.
SM00343. ZnF_C2HC. 1 hit.
[Graphical view ]
SUPFAMi SSF57756. SSF57756. 1 hit.
PROSITEi PS51282. DWNN. 1 hit.
PS50158. ZF_CCHC. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 546-1148 (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1356-1790 (ISOFORMS 1/2).
    Strain: C57BL/6J.
    Tissue: Corpora quadrigemina, Corpus striatum, Embryo, Head and Lung.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Strain: FVB/N-3.
    Tissue: Mammary tumor.
  4. "The proliferation potential protein-related (P2P-R) gene with domains encoding heterogeneous nuclear ribonucleoprotein association and Rb1 binding shows repressed expression during terminal differentiation."
    Witte M.M., Scott R.E.
    Proc. Natl. Acad. Sci. U.S.A. 94:1212-1217(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 154-1790 (ISOFORM 2), INTERACTION WITH RB1, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Strain: BALB/c.
  5. "PACT: cloning and characterization of a cellular p53 binding protein that interacts with Rb."
    Simons A., Melamed-Bessudo C., Wolkowicz R., Sperling J., Sperling R., Eisenbach L., Rotter V.
    Oncogene 14:145-155(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 204-1790 (ISOFORM 1), INTERACTION WITH TP53 AND RB1, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Strain: BALB/c.
    Tissue: Testis.
  6. "P2P-R protein localizes to the nucleolus of interphase cells and the periphery of chromosomes in mitotic cells which show maximum P2P-R immunoreactivity."
    Gao S., Witte M.M., Scott R.E.
    J. Cell. Physiol. 191:145-154(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE.
  7. Erratum
    Gao S., Witte M.M., Scott R.E.
    J. Cell. Physiol. 192:359-360(2002)
  8. "P2P-R protein overexpression restricts mitotic progression at prometaphase and promotes mitotic apoptosis."
    Gao S., Scott R.E.
    J. Cell. Physiol. 193:199-207(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  9. "Stable overexpression of specific segments of the P2P-R protein in human MCF-7 cells promotes camptothecin-induced apoptosis."
    Gao S., Scott R.E.
    J. Cell. Physiol. 197:445-452(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TP53.
  10. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-985; SER-1179; THR-1272 AND SER-1329, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  11. "PACT is a negative regulator of p53 and essential for cell growth and embryonic development."
    Li L., Deng B., Xing G., Teng Y., Tian C., Cheng X., Yin X., Yang J., Gao X., Zhu Y., Sun Q., Zhang L., Yang X., He F.
    Proc. Natl. Acad. Sci. U.S.A. 104:7951-7956(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE, FUNCTION.
  12. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1179 AND SER-1329, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-130, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiRBBP6_MOUSE
AccessioniPrimary (citable) accession number: P97868
Secondary accession number(s): P70287
, Q3TTR9, Q3TUM7, Q3UMP7, Q4U217, Q7TT06, Q8BNY8, Q8R399
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: May 16, 2006
Last modified: October 29, 2014
This is version 117 of the entry and version 5 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3