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Protein

E3 ubiquitin-protein ligase RBBP6

Gene

Rbbp6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome (By similarity). May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth retardation (PubMed:17470788). Regulates DNA-replication and common fragile sites (CFS) stability in a ZBTB38- and MCM10-dependent manner. Controls ZBTB38 protein stability and abundance via ubiquitination and proteasomal degradation, and ZBTB38 in turn negatively regulates the expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359).By similarity2 Publications

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri160 – 177CCHC-typePROSITE-ProRule annotationAdd BLAST18
Zinc fingeri260 – 301RING-type; degeneratePROSITE-ProRule annotationAdd BLAST42

GO - Molecular functioni

GO - Biological processi

  • cellular response to DNA damage stimulus Source: UniProtKB
  • DNA replication Source: UniProtKB-KW
  • embryonic organ development Source: MGI
  • in utero embryonic development Source: MGI
  • mRNA processing Source: InterPro
  • multicellular organism growth Source: MGI
  • protein ubiquitination involved in ubiquitin-dependent protein catabolic process Source: UniProtKB
  • regulation of DNA replication Source: UniProtKB
  • somite development Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

DNA damage, DNA replication, Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-983168. Antigen processing: Ubiquitination & Proteasome degradation.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase RBBP6 (EC:6.3.2.-)
Alternative name(s):
Proliferation potential-related protein
Protein P2P-R
Retinoblastoma-binding protein 6
p53-associated cellular protein of testis
Gene namesi
Name:Rbbp6
Synonyms:P2pr, Pact
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:894835. Rbbp6.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechi

Disruption phenotypei

Early embryonic lethality before E7.5, accompanied by accumulation of p53 and widespread apoptosis.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002343551 – 1790E3 ubiquitin-protein ligase RBBP6Add BLAST1790

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei130N6-acetyllysineCombined sources1
Modified residuei245PhosphoserineBy similarity1
Modified residuei246PhosphoserineBy similarity1
Modified residuei247PhosphoserineBy similarity1
Modified residuei248PhosphoserineBy similarity1
Modified residuei361PhosphoserineCombined sources1
Modified residuei517PhosphoserineBy similarity1
Modified residuei769PhosphoserineBy similarity1
Modified residuei771PhosphoserineBy similarity1
Modified residuei773PhosphoserineBy similarity1
Modified residuei781PhosphoserineBy similarity1
Modified residuei816PhosphoserineBy similarity1
Modified residuei862PhosphoserineBy similarity1
Modified residuei874PhosphoserineBy similarity1
Modified residuei958PhosphoserineBy similarity1
Modified residuei985PhosphothreonineCombined sources1
Cross-linki1107Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki1169Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei1179PhosphoserineCombined sources1
Modified residuei1272PhosphothreonineCombined sources1
Modified residuei1278PhosphoserineCombined sources1
Modified residuei1329PhosphoserineCombined sources1
Modified residuei1342PhosphoserineBy similarity1
Modified residuei1348PhosphoserineBy similarity1
Modified residuei1469PhosphothreonineBy similarity1
Modified residuei1646PhosphoserineBy similarity1
Modified residuei1648PhosphoserineCombined sources1
Modified residuei1651PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated by NEK6.By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP97868.
PaxDbiP97868.
PeptideAtlasiP97868.
PRIDEiP97868.

PTM databases

iPTMnetiP97868.
PhosphoSitePlusiP97868.

Expressioni

Tissue specificityi

Highly expressed in testis. Expressed at lower levels in brain, heart, kidney, liver, lung, skeletal muscle, spleen, thymus and tongue.2 Publications

Developmental stagei

Expression is reduced during terminal differentiation. Expression is induced in the G2/M phase of the cell cycle (at protein level).2 Publications

Gene expression databases

BgeeiENSMUSG00000030779.
CleanExiMM_RBBP6.
ExpressionAtlasiP97868. baseline and differential.
GenevisibleiP97868. MM.

Interactioni

Subunit structurei

Interacts with MDM2 and YBX1 (By similarity). Interacts also with p53/TP53 and RB1. Interacts with NEK6 (By similarity). Interacts with ZBTB38 (By similarity).By similarity3 Publications

Protein-protein interaction databases

BioGridi202817. 1 interactor.
IntActiP97868. 1 interactor.
MINTiMINT-4106375.
STRINGi10090.ENSMUSP00000049528.

Structurei

3D structure databases

ProteinModelPortaliP97868.
SMRiP97868.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 76DWNNPROSITE-ProRule annotationAdd BLAST73

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni983 – 1139Interaction with RB1Add BLAST157
Regioni1434 – 1544Interaction with p53Add BLAST111

Sequence similaritiesi

Contains 1 CCHC-type zinc finger.PROSITE-ProRule annotation
Contains 1 DWNN domain.PROSITE-ProRule annotation
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri160 – 177CCHC-typePROSITE-ProRule annotationAdd BLAST18
Zinc fingeri260 – 301RING-type; degeneratePROSITE-ProRule annotationAdd BLAST42

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG0314. Eukaryota.
COG5222. LUCA.
GeneTreeiENSGT00610000086096.
HOVERGENiHBG093889.
InParanoidiP97868.
KOiK10624.
OMAiKERYREW.
OrthoDBiEOG091G09Q6.
PhylomeDBiP97868.
TreeFamiTF350543.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
4.10.60.10. 1 hit.
InterProiIPR014891. DWNN_domain.
IPR033489. RBBP6.
IPR003613. Ubox_domain.
IPR025829. Zn_knuckle_CX2CX3GHX4C.
IPR001878. Znf_CCHC.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PANTHERiPTHR15439:SF3. PTHR15439:SF3. 3 hits.
PfamiPF08783. DWNN. 1 hit.
PF04564. U-box. 1 hit.
PF13696. zf-CCHC_2. 1 hit.
[Graphical view]
SMARTiSM01180. DWNN. 1 hit.
SM00184. RING. 1 hit.
SM00343. ZnF_C2HC. 1 hit.
[Graphical view]
SUPFAMiSSF57756. SSF57756. 1 hit.
PROSITEiPS51282. DWNN. 1 hit.
PS50158. ZF_CCHC. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P97868-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSCVHYKFSS KLNYDTVTFD GLHISLCDLK KQIMGREKLK AADSDLQITN
60 70 80 90 100
AQTKEEYTDD NALIPKNSSV IVRRIPIGGV KSTSKTYVIS RTEPVMGTTK
110 120 130 140 150
AIDDASASIS LAQLTKTANL AEANASEEDK IKAMMSQSGH EYDPINYMKK
160 170 180 190 200
TLVGPPPPSY TCFRCGKPGH YIKNCPTNGD KNFESGPRIK KSTGIPRSFM
210 220 230 240 250
MEVKDPNMKG AMLTNTGKYA IPTIDAEAYA IGKKEKPPFL PEEPSSSSEE
260 270 280 290 300
DDPIPDELLC LICKDIMTDA VVIPCCGNSY CDECIRTALL ESDEHTCPTC
310 320 330 340 350
HQNDVSPDAL IANKFLRQAV NNFKNETGYT KRLRKQLPPP PPPVPPPRPL
360 370 380 390 400
MQRNLQPLMR SPISRQQDPL MIPVTSSSAH SAPSISSLTS NPSALAPSVS
410 420 430 440 450
GNPSSAPAPV PDITATVSIS VHSEKSDGPF RDSDNKLLPA AALTSEHSKG
460 470 480 490 500
ASSIAITALM EEKGYQVPVL GTPSLLGQSL LHGQLIPTTG PVRINAARPG
510 520 530 540 550
GGRPGWEHSN KLGYLVSPPQ QIRRGERSCY RSINRGRHHS ERSQRTQGPS
560 570 580 590 600
LPATPVFVPV PPPPLYPPPP HTLPLPPGVP PPQFSPQFPP GQPPPAGYSV
610 620 630 640 650
PPPGFPPAPA NISTPWVSSG VQTAHSNTIP TTQAPPLSRE EFYREQRRLK
660 670 680 690 700
EEEKKKSKLD EFTNDFAKEL MEYKKIQKER RRSFSRSKSP YSGSSYSRSS
710 720 730 740 750
YTYSKSRSGS TRSRSYSRSF SRSHSRSYSR SPPYPRRGRG KSRNYRSRSR
760 770 780 790 800
SHGYHRSRSR SPPYRRYHSR SRSPQAFRGQ SPTKRNVPQG ETEREYFNRY
810 820 830 840 850
REVPPPYDIK AYYGRSVDFR DPFEKERYRE WERKYREWYE KYYKGYAVGA
860 870 880 890 900
QPRPSANRED FSPERLLPLN IRNSPFTRGR REDYAAGQSH RNRNLGGNYP
910 920 930 940 950
EKLSTRDSHN AKDNPKSKEK ESENVPGDGK GNKHKKHRKR RKGEESESFL
960 970 980 990 1000
NPELLETSRK CRESSGIDET KTDTLFVLPS RDDATPVRDE PMDAESITFK
1010 1020 1030 1040 1050
SVSDKDKREK DKPKVKSDKT KRKSDGSATA KKDNVLKPSK GPQEKVDGDR
1060 1070 1080 1090 1100
EKSPRSEPPL KKAKEEATKI DSVKPSSSSQ KDEKVTGTPR KAHSKSAKEH
1110 1120 1130 1140 1150
QEAKPAKDEK VKKDCSKDIK SEKPASKDEK AKKPEKNKLL DSKGEKRKRK
1160 1170 1180 1190 1200
TEEKSVDKDF ESSSMKISKV EGTEIVKPSP KRKMEGDVEK LERTPEKDKI
1210 1220 1230 1240 1250
ASSTTPAKKI KLNRETGKKI GNAENASTTK EPSEKLESTS SKIKQEKVKG
1260 1270 1280 1290 1300
KAKRKVAGSE GSSSTLVDYT STSSTGGSPV RKSEEKTDTK RTVIKTMEEY
1310 1320 1330 1340 1350
NNDNTAPAED VIIMIQVPQS KWDKDDFESE EEDVKTTQPI QSVGKPSSII
1360 1370 1380 1390 1400
KNVTTKPSAT AKYTEKESEQ PEKLQKLPKE ASHELMQHEL RSSKGSASSE
1410 1420 1430 1440 1450
KGRAKDREHS GSEKDNPDKR KSGAQPDKES TVDRLSEQGH FKTLSQSSKE
1460 1470 1480 1490 1500
TRTSEKHESV RGSSNKDFTP GRDKKVDYDS RDYSSSKRRD ERGELARRKD
1510 1520 1530 1540 1550
SPPRGKESLS GQKSKLREER DLPKKGAESK KSNSSPPRDK KPHDHKAPYE
1560 1570 1580 1590 1600
TKRPCEETKP VDKNSGKERE KHAAEARNGK ESSGGKLPCI PNPPDPPMEK
1610 1620 1630 1640 1650
ELAAGQVEKS AVKPKPQLSH SSRLSSDLTR ETDEAAFEPD YNESDSESNV
1660 1670 1680 1690 1700
SVKEEEAVAS ISKDLKEKTT EKAKESLTVA TASQPGADRS QSQSSPSVSP
1710 1720 1730 1740 1750
SRSHSPSGSQ TRSHSSSASS AGSQDSKKKK KKKEKKKHKK HKKHKKHKKH
1760 1770 1780 1790
AGADGDVEKS QKHKHKKKKA KKNKDKEKEK DDQKVRSVTV
Length:1,790
Mass (Da):199,587
Last modified:May 16, 2006 - v5
Checksum:i3909C30EB9DD2CE3
GO
Isoform 2 (identifier: P97868-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     653-686: Missing.

Show »
Length:1,756
Mass (Da):195,310
Checksum:iE3C0F009CC28107E
GO
Isoform 3 (identifier: P97868-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     102-123: IDDASASISLAQLTKTANLAEA → VCKNTITLFLHNCFYLYNVSVT
     124-1756: Missing.

Show »
Length:157
Mass (Da):17,888
Checksum:i39B749141C9B2FA6
GO

Sequence cautioni

The sequence AAC72432 differs from that shown. Reason: Frameshift at position 176.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti254I → F in AAB49620 (PubMed:9010216).Curated1
Sequence conflicti317 – 318RQ → GR in AAC72432 (PubMed:9037032).Curated2
Sequence conflicti341P → H in AAB49620 (PubMed:9010216).Curated1
Sequence conflicti418S → F in AAC72432 (PubMed:9037032).Curated1
Sequence conflicti421V → S in AAB49620 (PubMed:9010216).Curated1
Sequence conflicti580P → L in AAC72432 (PubMed:9037032).Curated1
Sequence conflicti595P → T in AAC72432 (PubMed:9037032).Curated1
Sequence conflicti615 – 622PWVSSGVQ → ACFSPGVP in AAC72432 (PubMed:9037032).Curated8
Sequence conflicti629I → M in AAC72432 (PubMed:9037032).Curated1
Sequence conflicti636P → L in AAC72432 (PubMed:9037032).Curated1
Sequence conflicti647R → K in AAC72432 (PubMed:9037032).Curated1
Sequence conflicti689S → F in AAC72432 (PubMed:9037032).Curated1
Sequence conflicti703Y → D in AAC72432 (PubMed:9037032).Curated1
Sequence conflicti789Q → R in AAC72432 (PubMed:9037032).Curated1
Sequence conflicti940R → Q in BAE36255 (PubMed:16141072).Curated1
Sequence conflicti941R → RNEE in AAC72432 (PubMed:9037032).Curated1
Sequence conflicti956 – 958ETS → GKF in AAC72432 (PubMed:9037032).Curated3
Sequence conflicti963E → G in AAC72432 (PubMed:9037032).Curated1
Sequence conflicti978L → F in AAC72432 (PubMed:9037032).Curated1
Sequence conflicti982D → E in AAC72432 (PubMed:9037032).Curated1
Sequence conflicti1012K → N in AAB49620 (PubMed:9010216).Curated1
Sequence conflicti1290K → T in AAC72432 (PubMed:9037032).Curated1
Sequence conflicti1316Q → H in AAC72432 (PubMed:9037032).Curated1
Sequence conflicti1564N → I in AAC72432 (PubMed:9037032).Curated1
Sequence conflicti1581E → D in AAC72432 (PubMed:9037032).Curated1
Sequence conflicti1591P → L in AAC72432 (PubMed:9037032).Curated1
Sequence conflicti1596P → L in AAC72432 (PubMed:9037032).Curated1
Sequence conflicti1604A → V in AAC72432 (PubMed:9037032).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_018285102 – 123IDDAS…NLAEA → VCKNTITLFLHNCFYLYNVS VT in isoform 3. 2 PublicationsAdd BLAST22
Alternative sequenceiVSP_018286124 – 1756Missing in isoform 3. 2 PublicationsAdd BLAST1633
Alternative sequenceiVSP_018287653 – 686Missing in isoform 2. 2 PublicationsAdd BLAST34

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK045635 mRNA. Translation: BAC32441.1.
AK079129 mRNA. Translation: BAC37553.1.
AK081261 mRNA. Translation: BAC38179.1.
AK144758 mRNA. Translation: BAE26051.1.
AK160656 mRNA. Translation: BAE35944.1.
AK161231 mRNA. Translation: BAE36255.1.
AC125221 Genomic DNA. No translation available.
BC025874 mRNA. Translation: AAH25874.1.
U83913 mRNA. Translation: AAC72432.1. Frameshift.
U28789 mRNA. Translation: AAB49620.1.
CCDSiCCDS52387.1. [P97868-1]
PIRiT42727.
RefSeqiNP_035377.2. NM_011247.2. [P97868-1]
NP_778188.1. NM_175023.3.
XP_006507533.1. XM_006507470.3. [P97868-2]
UniGeneiMm.4480.

Genome annotation databases

EnsembliENSMUST00000052135; ENSMUSP00000049528; ENSMUSG00000030779. [P97868-1]
ENSMUST00000071590; ENSMUSP00000071519; ENSMUSG00000030779. [P97868-2]
GeneIDi19647.
KEGGimmu:19647.
UCSCiuc009jow.2. mouse. [P97868-3]
uc009joy.2. mouse. [P97868-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK045635 mRNA. Translation: BAC32441.1.
AK079129 mRNA. Translation: BAC37553.1.
AK081261 mRNA. Translation: BAC38179.1.
AK144758 mRNA. Translation: BAE26051.1.
AK160656 mRNA. Translation: BAE35944.1.
AK161231 mRNA. Translation: BAE36255.1.
AC125221 Genomic DNA. No translation available.
BC025874 mRNA. Translation: AAH25874.1.
U83913 mRNA. Translation: AAC72432.1. Frameshift.
U28789 mRNA. Translation: AAB49620.1.
CCDSiCCDS52387.1. [P97868-1]
PIRiT42727.
RefSeqiNP_035377.2. NM_011247.2. [P97868-1]
NP_778188.1. NM_175023.3.
XP_006507533.1. XM_006507470.3. [P97868-2]
UniGeneiMm.4480.

3D structure databases

ProteinModelPortaliP97868.
SMRiP97868.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi202817. 1 interactor.
IntActiP97868. 1 interactor.
MINTiMINT-4106375.
STRINGi10090.ENSMUSP00000049528.

PTM databases

iPTMnetiP97868.
PhosphoSitePlusiP97868.

Proteomic databases

MaxQBiP97868.
PaxDbiP97868.
PeptideAtlasiP97868.
PRIDEiP97868.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000052135; ENSMUSP00000049528; ENSMUSG00000030779. [P97868-1]
ENSMUST00000071590; ENSMUSP00000071519; ENSMUSG00000030779. [P97868-2]
GeneIDi19647.
KEGGimmu:19647.
UCSCiuc009jow.2. mouse. [P97868-3]
uc009joy.2. mouse. [P97868-1]

Organism-specific databases

CTDi5930.
MGIiMGI:894835. Rbbp6.

Phylogenomic databases

eggNOGiKOG0314. Eukaryota.
COG5222. LUCA.
GeneTreeiENSGT00610000086096.
HOVERGENiHBG093889.
InParanoidiP97868.
KOiK10624.
OMAiKERYREW.
OrthoDBiEOG091G09Q6.
PhylomeDBiP97868.
TreeFamiTF350543.

Enzyme and pathway databases

UniPathwayiUPA00143.
ReactomeiR-MMU-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Miscellaneous databases

ChiTaRSiRbbp6. mouse.
PROiP97868.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030779.
CleanExiMM_RBBP6.
ExpressionAtlasiP97868. baseline and differential.
GenevisibleiP97868. MM.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
4.10.60.10. 1 hit.
InterProiIPR014891. DWNN_domain.
IPR033489. RBBP6.
IPR003613. Ubox_domain.
IPR025829. Zn_knuckle_CX2CX3GHX4C.
IPR001878. Znf_CCHC.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PANTHERiPTHR15439:SF3. PTHR15439:SF3. 3 hits.
PfamiPF08783. DWNN. 1 hit.
PF04564. U-box. 1 hit.
PF13696. zf-CCHC_2. 1 hit.
[Graphical view]
SMARTiSM01180. DWNN. 1 hit.
SM00184. RING. 1 hit.
SM00343. ZnF_C2HC. 1 hit.
[Graphical view]
SUPFAMiSSF57756. SSF57756. 1 hit.
PROSITEiPS51282. DWNN. 1 hit.
PS50158. ZF_CCHC. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRBBP6_MOUSE
AccessioniPrimary (citable) accession number: P97868
Secondary accession number(s): P70287
, Q3TTR9, Q3TUM7, Q3UMP7, Q4U217, Q7TT06, Q8BNY8, Q8R399
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: May 16, 2006
Last modified: November 2, 2016
This is version 137 of the entry and version 5 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.