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Protein

Peroxisomal targeting signal 2 receptor

Gene

Pex7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds to the N-terminal PTS2-type peroxisomal targeting signal and plays an essential role in peroxisomal protein import.

GO - Molecular functioni

GO - Biological processi

  • endochondral ossification Source: MGI
  • ether lipid biosynthetic process Source: MGI
  • fatty acid beta-oxidation Source: MGI
  • neuron migration Source: MGI
  • peroxisome organization Source: MGI
  • protein import into peroxisome matrix Source: MGI
  • protein targeting to peroxisome Source: MGI
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisomal targeting signal 2 receptor
Short name:
PTS2 receptor
Alternative name(s):
Peroxin-7
Gene namesi
Name:Pex7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1321392. Pex7.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: MGI
  • peroxisomal matrix Source: MGI
  • peroxisome Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 318318Peroxisomal targeting signal 2 receptorPRO_0000051117Add
BLAST

Proteomic databases

EPDiP97865.
MaxQBiP97865.
PaxDbiP97865.
PRIDEiP97865.

PTM databases

iPTMnetiP97865.
PhosphoSiteiP97865.

Expressioni

Gene expression databases

BgeeiP97865.
CleanExiMM_PEX7.
ExpressionAtlasiP97865. baseline and differential.
GenevisibleiP97865. MM.

Interactioni

Subunit structurei

Interacts with PEX5.

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020182.

Structurei

3D structure databases

ProteinModelPortaliP97865.
SMRiP97865. Positions 11-310.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati60 – 9132WD 1Add
BLAST
Repeati104 – 13633WD 2Add
BLAST
Repeati148 – 17932WD 3Add
BLAST
Repeati191 – 22232WD 4Add
BLAST
Repeati235 – 26632WD 5Add
BLAST
Repeati279 – 31032WD 6Add
BLAST

Sequence similaritiesi

Belongs to the WD repeat peroxin-7 family.Curated
Contains 6 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0277. Eukaryota.
ENOG410XNVU. LUCA.
GeneTreeiENSGT00810000125459.
HOGENOMiHOG000204332.
HOVERGENiHBG003354.
InParanoidiP97865.
KOiK13341.
OMAiCVYQALF.
OrthoDBiEOG7VQJD3.
PhylomeDBiP97865.
TreeFamiTF323220.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 4 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 3 hits.
PS50082. WD_REPEATS_2. 4 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P97865-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAARTLRVP GRHGYAAEFS PYLPGRLACA AAQHYGIAGC GTLLVLDQNE
60 70 80 90 100
SGLQIFRSFD WNDGLFDVTW SENNEHVLVT CSGDGSLQLW DTAKATGPLQ
110 120 130 140 150
VYKEHTQEVY SVDWSQTRGE QLVVSGSWDQ TVKVWDPTVG NSLCTFRGHE
160 170 180 190 200
SVIYSTIWSP HIPGCFASAS GDQTLRIWDV KTTGVRIVIP AHQTEILSCD
210 220 230 240 250
WCKYNENLVV TGAVDCSLRG WDLRNVRQPV FELLGHTYAI RRVKFSPFHA
260 270 280 290 300
SVLASCSYDF TVRFWNFSKP DPLLETVEHH TEFTCGLDLS LQSPTQVADC
310
SWDETIKIYD PVCLTVPG
Length:318
Mass (Da):35,502
Last modified:May 1, 1997 - v1
Checksum:i7B7591FE8F715CFA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U69171 mRNA. Translation: AAB49755.1.
BC132213 mRNA. Translation: AAI32214.1.
BC132503 mRNA. Translation: AAI32504.1.
CCDSiCCDS23720.1.
RefSeqiNP_032848.1. NM_008822.2.
UniGeneiMm.338363.

Genome annotation databases

EnsembliENSMUST00000020182; ENSMUSP00000020182; ENSMUSG00000020003.
GeneIDi18634.
KEGGimmu:18634.
UCSCiuc007enl.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U69171 mRNA. Translation: AAB49755.1.
BC132213 mRNA. Translation: AAI32214.1.
BC132503 mRNA. Translation: AAI32504.1.
CCDSiCCDS23720.1.
RefSeqiNP_032848.1. NM_008822.2.
UniGeneiMm.338363.

3D structure databases

ProteinModelPortaliP97865.
SMRiP97865. Positions 11-310.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020182.

PTM databases

iPTMnetiP97865.
PhosphoSiteiP97865.

Proteomic databases

EPDiP97865.
MaxQBiP97865.
PaxDbiP97865.
PRIDEiP97865.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020182; ENSMUSP00000020182; ENSMUSG00000020003.
GeneIDi18634.
KEGGimmu:18634.
UCSCiuc007enl.2. mouse.

Organism-specific databases

CTDi5191.
MGIiMGI:1321392. Pex7.

Phylogenomic databases

eggNOGiKOG0277. Eukaryota.
ENOG410XNVU. LUCA.
GeneTreeiENSGT00810000125459.
HOGENOMiHOG000204332.
HOVERGENiHBG003354.
InParanoidiP97865.
KOiK13341.
OMAiCVYQALF.
OrthoDBiEOG7VQJD3.
PhylomeDBiP97865.
TreeFamiTF323220.

Miscellaneous databases

PROiP97865.
SOURCEiSearch...

Gene expression databases

BgeeiP97865.
CleanExiMM_PEX7.
ExpressionAtlasiP97865. baseline and differential.
GenevisibleiP97865. MM.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 4 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 3 hits.
PS50082. WD_REPEATS_2. 4 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Human PEX7 encodes the peroxisomal PTS2 receptor and is responsible for rhizomelic chondrodysplasia punctata."
    Braverman N., Steel G., Obie C., Moser A., Moser H., Gould S.J., Valle D.
    Nat. Genet. 15:369-376(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiPEX7_MOUSE
AccessioniPrimary (citable) accession number: P97865
Secondary accession number(s): A2RSR2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 1, 1997
Last modified: June 8, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.