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Protein

Peroxisomal targeting signal 2 receptor

Gene

Pex7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds to the N-terminal PTS2-type peroxisomal targeting signal and plays an essential role in peroxisomal protein import.

GO - Molecular functioni

GO - Biological processi

  • endochondral ossification Source: MGI
  • ether lipid biosynthetic process Source: MGI
  • fatty acid beta-oxidation Source: MGI
  • neuron migration Source: MGI
  • peroxisome organization Source: MGI
  • protein import into peroxisome matrix Source: MGI
  • protein targeting to peroxisome Source: MGI

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-9033241 Peroxisomal protein import

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisomal targeting signal 2 receptor
Short name:
PTS2 receptor
Alternative name(s):
Peroxin-7
Gene namesi
Name:Pex7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1321392 Pex7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000511171 – 318Peroxisomal targeting signal 2 receptorAdd BLAST318

Proteomic databases

EPDiP97865
MaxQBiP97865
PaxDbiP97865
PRIDEiP97865

PTM databases

iPTMnetiP97865
PhosphoSitePlusiP97865

Expressioni

Gene expression databases

BgeeiENSMUSG00000020003
CleanExiMM_PEX7
ExpressionAtlasiP97865 baseline and differential
GenevisibleiP97865 MM

Interactioni

Subunit structurei

Interacts with PEX5.

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020182

Structurei

3D structure databases

ProteinModelPortaliP97865
SMRiP97865
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati60 – 91WD 1Add BLAST32
Repeati104 – 136WD 2Add BLAST33
Repeati148 – 179WD 3Add BLAST32
Repeati191 – 222WD 4Add BLAST32
Repeati235 – 266WD 5Add BLAST32
Repeati279 – 310WD 6Add BLAST32

Sequence similaritiesi

Belongs to the WD repeat peroxin-7 family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0277 Eukaryota
ENOG410XNVU LUCA
GeneTreeiENSGT00910000144285
HOGENOMiHOG000204332
HOVERGENiHBG003354
InParanoidiP97865
KOiK13341
OMAiNYDFTTR
OrthoDBiEOG091G0C6L
PhylomeDBiP97865
TreeFamiTF323220

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00400 WD40, 4 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00320 WD40, 6 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 3 hits
PS50082 WD_REPEATS_2, 4 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

P97865-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAARTLRVP GRHGYAAEFS PYLPGRLACA AAQHYGIAGC GTLLVLDQNE
60 70 80 90 100
SGLQIFRSFD WNDGLFDVTW SENNEHVLVT CSGDGSLQLW DTAKATGPLQ
110 120 130 140 150
VYKEHTQEVY SVDWSQTRGE QLVVSGSWDQ TVKVWDPTVG NSLCTFRGHE
160 170 180 190 200
SVIYSTIWSP HIPGCFASAS GDQTLRIWDV KTTGVRIVIP AHQTEILSCD
210 220 230 240 250
WCKYNENLVV TGAVDCSLRG WDLRNVRQPV FELLGHTYAI RRVKFSPFHA
260 270 280 290 300
SVLASCSYDF TVRFWNFSKP DPLLETVEHH TEFTCGLDLS LQSPTQVADC
310
SWDETIKIYD PVCLTVPG
Length:318
Mass (Da):35,502
Last modified:May 1, 1997 - v1
Checksum:i7B7591FE8F715CFA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U69171 mRNA Translation: AAB49755.1
BC132213 mRNA Translation: AAI32214.1
BC132503 mRNA Translation: AAI32504.1
CCDSiCCDS23720.1
RefSeqiNP_032848.1, NM_008822.2
UniGeneiMm.338363

Genome annotation databases

EnsembliENSMUST00000020182; ENSMUSP00000020182; ENSMUSG00000020003
GeneIDi18634
KEGGimmu:18634
UCSCiuc007enl.2 mouse

Similar proteinsi

Entry informationi

Entry nameiPEX7_MOUSE
AccessioniPrimary (citable) accession number: P97865
Secondary accession number(s): A2RSR2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 1, 1997
Last modified: May 23, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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