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Protein

Keratin, type II cuticular Hb6

Gene

Krt86

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Miscellaneous

There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).

GO - Molecular functioni

Enzyme and pathway databases

ReactomeiR-MMU-6805567. Keratinization.
R-MMU-6809371. Formation of the cornified envelope.

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type II cuticular Hb6
Alternative name(s):
Keratin-86
Short name:
K86
Type II hair keratin Hb6
Type-II keratin Kb26
Gene namesi
Name:Krt86
Synonyms:Krt2-10, Krthb6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:109362. Krt86.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Intermediate filament, Keratin

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000637051 – 486Keratin, type II cuticular Hb6Add BLAST486

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki212Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiP97861.
PaxDbiP97861.
PRIDEiP97861.

PTM databases

iPTMnetiP97861.
PhosphoSitePlusiP97861.

Expressioni

Gene expression databases

BgeeiENSMUSG00000067614.
CleanExiMM_KRT86.
ExpressionAtlasiP97861. baseline and differential.
GenevisibleiP97861. MM.

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins.

Protein-protein interaction databases

BioGridi201031. 1 interactor.

Structurei

3D structure databases

ProteinModelPortaliP97861.
SMRiP97861.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini106 – 417IF rodAdd BLAST312

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 106HeadAdd BLAST106
Regioni107 – 141Coil 1AAdd BLAST35
Regioni142 – 151Linker 110
Regioni152 – 252Coil 1BAdd BLAST101
Regioni253 – 269Linker 12Add BLAST17
Regioni270 – 413Coil 2Add BLAST144
Regioni414 – 486TailAdd BLAST73

Sequence similaritiesi

Belongs to the intermediate filament family.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IH1H. Eukaryota.
ENOG41113GZ. LUCA.
GeneTreeiENSGT00830000128228.
HOGENOMiHOG000230976.
HOVERGENiHBG013015.
InParanoidiP97861.
KOiK07605.
OMAiQNCKLEA.
OrthoDBiEOG091G06FG.
PhylomeDBiP97861.
TreeFamiTF317854.

Family and domain databases

InterProiView protein in InterPro
IPR009030. Growth_fac_rcpt_cys_sf.
IPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR032444. Keratin_2_head.
IPR003054. Keratin_II.
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiView protein in Pfam
PF00038. Filament. 1 hit.
PF16208. Keratin_2_head. 1 hit.
PRINTSiPR01276. TYPE2KERATIN.
SMARTiView protein in SMART
SM01391. Filament. 1 hit.
SUPFAMiSSF57184. SSF57184. 2 hits.
PROSITEiView protein in PROSITE
PS00226. IF_ROD_1. 1 hit.
PS51842. IF_ROD_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P97861-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTCGSYCGGR AFSCASACGP RPGRCCISAA PYRGISCYRG LSGGFGSQSV
60 70 80 90 100
CGAFRSGSCG RSFGYRSGGI CGPSPPCITT VSVNESLLTP LNLEIDPNAQ
110 120 130 140 150
CVKHEEKEQI KCLNSKFAAF IDKVRFLEQQ NKLLETKWQF YQNRKCCESN
160 170 180 190 200
MEPLFEGYIE ALRREAECVE ADSGRLAAEL NHAQESMEGY KKRYEEEVSL
210 220 230 240 250
RATAENEFVA LKKDVDCAYL RKSDLEANAE ALTQETDFLR RMYDEETRIL
260 270 280 290 300
HSHISDTSIV VKMDNSRDLN MDCVVAEIKA QYDDIASRSR AEAESWYRTK
310 320 330 340 350
CEEIKATVIR HGETLRRTRE EINELNRMIQ RLTAEIENAK CQNTKLEAAV
360 370 380 390 400
TQSEQQGEAA LADARCKLAE LEGALQKAKQ DMACLLKEYQ EVMNSKLGLD
410 420 430 440 450
VEITTYRRLL EGEEQRLCEG VGSVNVCVSS SRGGVVCGDL CVSGTAPAVN
460 470 480
TRVCSAPCSG NVVVGTPNAC APCAGAGACS GGCKKC
Length:486
Mass (Da):53,251
Last modified:November 22, 2005 - v2
Checksum:i8EABB193B38C8F2A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK161149 mRNA. Translation: BAE36215.1.
X99143 mRNA. Translation: CAA67580.1.
CCDSiCCDS37218.1.
RefSeqiNP_034797.1. NM_010667.2.
UniGeneiMm.383183.

Genome annotation databases

EnsembliENSMUST00000088049; ENSMUSP00000085365; ENSMUSG00000067614.
GeneIDi16679.
KEGGimmu:16679.
UCSCiuc007xti.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiKRT86_MOUSE
AccessioniPrimary (citable) accession number: P97861
Secondary accession number(s): Q3TTV9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: November 22, 2005
Last modified: November 22, 2017
This is version 134 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families