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P97861

- KRT86_MOUSE

UniProt

P97861 - KRT86_MOUSE

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Protein
Keratin, type II cuticular Hb6
Gene
Krt86, Krt2-10, Krthb6
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. structural molecule activity Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type II cuticular Hb6
Alternative name(s):
Keratin-86
Short name:
K86
Type II hair keratin Hb6
Type-II keratin Kb26
Gene namesi
Name:Krt86
Synonyms:Krt2-10, Krthb6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 15

Organism-specific databases

MGIiMGI:109362. Krt86.

Subcellular locationi

GO - Cellular componenti

  1. keratin filament Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Intermediate filament, Keratin

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 486486Keratin, type II cuticular Hb6
PRO_0000063705Add
BLAST

Proteomic databases

PaxDbiP97861.
PRIDEiP97861.

PTM databases

PhosphoSiteiP97861.

Expressioni

Gene expression databases

ArrayExpressiP97861.
BgeeiP97861.
CleanExiMM_KRT86.
GenevestigatoriP97861.

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins.

Protein-protein interaction databases

BioGridi201031. 1 interaction.
STRINGi10090.ENSMUSP00000085365.

Structurei

3D structure databases

ProteinModelPortaliP97861.
SMRiP97861. Positions 106-254, 272-412.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 106106Head
Add
BLAST
Regioni107 – 413307Rod
Add
BLAST
Regioni107 – 14135Coil 1A
Add
BLAST
Regioni142 – 15110Linker 1
Regioni152 – 252101Coil 1B
Add
BLAST
Regioni253 – 26917Linker 12
Add
BLAST
Regioni270 – 413144Coil 2
Add
BLAST
Regioni414 – 48673Tail
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG149039.
GeneTreeiENSGT00670000097789.
HOGENOMiHOG000230976.
HOVERGENiHBG013015.
InParanoidiP97861.
KOiK07605.
OMAiCSGGCKK.
OrthoDBiEOG7B05CW.
PhylomeDBiP97861.
TreeFamiTF317854.

Family and domain databases

InterProiIPR009030. Growth_fac_rcpt_N_dom.
IPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR003054. Keratin_II.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01276. TYPE2KERATIN.
SUPFAMiSSF57184. SSF57184. 2 hits.
PROSITEiPS00226. IF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P97861-1 [UniParc]FASTAAdd to Basket

« Hide

MTCGSYCGGR AFSCASACGP RPGRCCISAA PYRGISCYRG LSGGFGSQSV    50
CGAFRSGSCG RSFGYRSGGI CGPSPPCITT VSVNESLLTP LNLEIDPNAQ 100
CVKHEEKEQI KCLNSKFAAF IDKVRFLEQQ NKLLETKWQF YQNRKCCESN 150
MEPLFEGYIE ALRREAECVE ADSGRLAAEL NHAQESMEGY KKRYEEEVSL 200
RATAENEFVA LKKDVDCAYL RKSDLEANAE ALTQETDFLR RMYDEETRIL 250
HSHISDTSIV VKMDNSRDLN MDCVVAEIKA QYDDIASRSR AEAESWYRTK 300
CEEIKATVIR HGETLRRTRE EINELNRMIQ RLTAEIENAK CQNTKLEAAV 350
TQSEQQGEAA LADARCKLAE LEGALQKAKQ DMACLLKEYQ EVMNSKLGLD 400
VEITTYRRLL EGEEQRLCEG VGSVNVCVSS SRGGVVCGDL CVSGTAPAVN 450
TRVCSAPCSG NVVVGTPNAC APCAGAGACS GGCKKC 486
Length:486
Mass (Da):53,251
Last modified:November 22, 2005 - v2
Checksum:i8EABB193B38C8F2A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK161149 mRNA. Translation: BAE36215.1.
X99143 mRNA. Translation: CAA67580.1.
CCDSiCCDS37218.1.
RefSeqiNP_034797.1. NM_010667.2.
UniGeneiMm.383183.

Genome annotation databases

EnsembliENSMUST00000088049; ENSMUSP00000085365; ENSMUSG00000067614.
GeneIDi16679.
KEGGimmu:16679.
UCSCiuc007xti.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK161149 mRNA. Translation: BAE36215.1 .
X99143 mRNA. Translation: CAA67580.1 .
CCDSi CCDS37218.1.
RefSeqi NP_034797.1. NM_010667.2.
UniGenei Mm.383183.

3D structure databases

ProteinModelPortali P97861.
SMRi P97861. Positions 106-254, 272-412.
ModBasei Search...

Protein-protein interaction databases

BioGridi 201031. 1 interaction.
STRINGi 10090.ENSMUSP00000085365.

PTM databases

PhosphoSitei P97861.

Proteomic databases

PaxDbi P97861.
PRIDEi P97861.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000088049 ; ENSMUSP00000085365 ; ENSMUSG00000067614 .
GeneIDi 16679.
KEGGi mmu:16679.
UCSCi uc007xti.1. mouse.

Organism-specific databases

CTDi 3892.
MGIi MGI:109362. Krt86.

Phylogenomic databases

eggNOGi NOG149039.
GeneTreei ENSGT00670000097789.
HOGENOMi HOG000230976.
HOVERGENi HBG013015.
InParanoidi P97861.
KOi K07605.
OMAi CSGGCKK.
OrthoDBi EOG7B05CW.
PhylomeDBi P97861.
TreeFami TF317854.

Miscellaneous databases

NextBioi 290421.
PROi P97861.
SOURCEi Search...

Gene expression databases

ArrayExpressi P97861.
Bgeei P97861.
CleanExi MM_KRT86.
Genevestigatori P97861.

Family and domain databases

InterProi IPR009030. Growth_fac_rcpt_N_dom.
IPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR003054. Keratin_II.
[Graphical view ]
PANTHERi PTHR23239. PTHR23239. 1 hit.
Pfami PF00038. Filament. 1 hit.
[Graphical view ]
PRINTSi PR01276. TYPE2KERATIN.
SUPFAMi SSF57184. SSF57184. 2 hits.
PROSITEi PS00226. IF. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Skin.
  2. "Sequences and differential expression of three novel human type-II hair keratins."
    Rogers M.A., Langbein L., Praetzel S., Krieg T., Winter H., Schweizer J.
    Differentiation 61:187-194(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 31-486.

Entry informationi

Entry nameiKRT86_MOUSE
AccessioniPrimary (citable) accession number: P97861
Secondary accession number(s): Q3TTV9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: November 22, 2005
Last modified: July 9, 2014
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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