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P97861

- KRT86_MOUSE

UniProt

P97861 - KRT86_MOUSE

Protein

Keratin, type II cuticular Hb6

Gene

Krt86

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 2 (22 Nov 2005)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. structural molecule activity Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Keratin, type II cuticular Hb6
    Alternative name(s):
    Keratin-86
    Short name:
    K86
    Type II hair keratin Hb6
    Type-II keratin Kb26
    Gene namesi
    Name:Krt86
    Synonyms:Krt2-10, Krthb6
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 15

    Organism-specific databases

    MGIiMGI:109362. Krt86.

    Subcellular locationi

    GO - Cellular componenti

    1. keratin filament Source: InterPro

    Keywords - Cellular componenti

    Intermediate filament, Keratin

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 486486Keratin, type II cuticular Hb6PRO_0000063705Add
    BLAST

    Proteomic databases

    PaxDbiP97861.
    PRIDEiP97861.

    PTM databases

    PhosphoSiteiP97861.

    Expressioni

    Gene expression databases

    ArrayExpressiP97861.
    BgeeiP97861.
    CleanExiMM_KRT86.
    GenevestigatoriP97861.

    Interactioni

    Subunit structurei

    Heterotetramer of two type I and two type II keratins.

    Protein-protein interaction databases

    BioGridi201031. 1 interaction.
    STRINGi10090.ENSMUSP00000085365.

    Structurei

    3D structure databases

    ProteinModelPortaliP97861.
    SMRiP97861. Positions 106-254, 272-412.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 106106HeadAdd
    BLAST
    Regioni107 – 413307RodAdd
    BLAST
    Regioni107 – 14135Coil 1AAdd
    BLAST
    Regioni142 – 15110Linker 1
    Regioni152 – 252101Coil 1BAdd
    BLAST
    Regioni253 – 26917Linker 12Add
    BLAST
    Regioni270 – 413144Coil 2Add
    BLAST
    Regioni414 – 48673TailAdd
    BLAST

    Sequence similaritiesi

    Belongs to the intermediate filament family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG149039.
    GeneTreeiENSGT00670000097789.
    HOGENOMiHOG000230976.
    HOVERGENiHBG013015.
    InParanoidiP97861.
    KOiK07605.
    OMAiCSGGCKK.
    OrthoDBiEOG7B05CW.
    PhylomeDBiP97861.
    TreeFamiTF317854.

    Family and domain databases

    InterProiIPR009030. Growth_fac_rcpt_N_dom.
    IPR001664. IF.
    IPR018039. Intermediate_filament_CS.
    IPR003054. Keratin_II.
    [Graphical view]
    PANTHERiPTHR23239. PTHR23239. 1 hit.
    PfamiPF00038. Filament. 1 hit.
    [Graphical view]
    PRINTSiPR01276. TYPE2KERATIN.
    SUPFAMiSSF57184. SSF57184. 2 hits.
    PROSITEiPS00226. IF. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P97861-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTCGSYCGGR AFSCASACGP RPGRCCISAA PYRGISCYRG LSGGFGSQSV    50
    CGAFRSGSCG RSFGYRSGGI CGPSPPCITT VSVNESLLTP LNLEIDPNAQ 100
    CVKHEEKEQI KCLNSKFAAF IDKVRFLEQQ NKLLETKWQF YQNRKCCESN 150
    MEPLFEGYIE ALRREAECVE ADSGRLAAEL NHAQESMEGY KKRYEEEVSL 200
    RATAENEFVA LKKDVDCAYL RKSDLEANAE ALTQETDFLR RMYDEETRIL 250
    HSHISDTSIV VKMDNSRDLN MDCVVAEIKA QYDDIASRSR AEAESWYRTK 300
    CEEIKATVIR HGETLRRTRE EINELNRMIQ RLTAEIENAK CQNTKLEAAV 350
    TQSEQQGEAA LADARCKLAE LEGALQKAKQ DMACLLKEYQ EVMNSKLGLD 400
    VEITTYRRLL EGEEQRLCEG VGSVNVCVSS SRGGVVCGDL CVSGTAPAVN 450
    TRVCSAPCSG NVVVGTPNAC APCAGAGACS GGCKKC 486
    Length:486
    Mass (Da):53,251
    Last modified:November 22, 2005 - v2
    Checksum:i8EABB193B38C8F2A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK161149 mRNA. Translation: BAE36215.1.
    X99143 mRNA. Translation: CAA67580.1.
    CCDSiCCDS37218.1.
    RefSeqiNP_034797.1. NM_010667.2.
    UniGeneiMm.383183.

    Genome annotation databases

    EnsembliENSMUST00000088049; ENSMUSP00000085365; ENSMUSG00000067614.
    GeneIDi16679.
    KEGGimmu:16679.
    UCSCiuc007xti.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK161149 mRNA. Translation: BAE36215.1 .
    X99143 mRNA. Translation: CAA67580.1 .
    CCDSi CCDS37218.1.
    RefSeqi NP_034797.1. NM_010667.2.
    UniGenei Mm.383183.

    3D structure databases

    ProteinModelPortali P97861.
    SMRi P97861. Positions 106-254, 272-412.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 201031. 1 interaction.
    STRINGi 10090.ENSMUSP00000085365.

    PTM databases

    PhosphoSitei P97861.

    Proteomic databases

    PaxDbi P97861.
    PRIDEi P97861.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000088049 ; ENSMUSP00000085365 ; ENSMUSG00000067614 .
    GeneIDi 16679.
    KEGGi mmu:16679.
    UCSCi uc007xti.1. mouse.

    Organism-specific databases

    CTDi 3892.
    MGIi MGI:109362. Krt86.

    Phylogenomic databases

    eggNOGi NOG149039.
    GeneTreei ENSGT00670000097789.
    HOGENOMi HOG000230976.
    HOVERGENi HBG013015.
    InParanoidi P97861.
    KOi K07605.
    OMAi CSGGCKK.
    OrthoDBi EOG7B05CW.
    PhylomeDBi P97861.
    TreeFami TF317854.

    Miscellaneous databases

    NextBioi 290421.
    PROi P97861.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P97861.
    Bgeei P97861.
    CleanExi MM_KRT86.
    Genevestigatori P97861.

    Family and domain databases

    InterProi IPR009030. Growth_fac_rcpt_N_dom.
    IPR001664. IF.
    IPR018039. Intermediate_filament_CS.
    IPR003054. Keratin_II.
    [Graphical view ]
    PANTHERi PTHR23239. PTHR23239. 1 hit.
    Pfami PF00038. Filament. 1 hit.
    [Graphical view ]
    PRINTSi PR01276. TYPE2KERATIN.
    SUPFAMi SSF57184. SSF57184. 2 hits.
    PROSITEi PS00226. IF. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Skin.
    2. "Sequences and differential expression of three novel human type-II hair keratins."
      Rogers M.A., Langbein L., Praetzel S., Krieg T., Winter H., Schweizer J.
      Differentiation 61:187-194(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 31-486.

    Entry informationi

    Entry nameiKRT86_MOUSE
    AccessioniPrimary (citable) accession number: P97861
    Secondary accession number(s): Q3TTV9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 29, 2004
    Last sequence update: November 22, 2005
    Last modified: October 1, 2014
    This is version 108 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3