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P97861 (KRT86_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 105. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Keratin, type II cuticular Hb6
Alternative name(s):
Keratin-86
Short name=K86
Type II hair keratin Hb6
Type-II keratin Kb26
Gene names
Name:Krt86
Synonyms:Krt2-10, Krthb6
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length486 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subunit structure

Heterotetramer of two type I and two type II keratins.

Miscellaneous

There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).

Sequence similarities

Belongs to the intermediate filament family.

Ontologies

Keywords
   Cellular componentIntermediate filament
Keratin
   DomainCoiled coil
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentkeratin filament

Inferred from electronic annotation. Source: InterPro

   Molecular_functionstructural molecule activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 486486Keratin, type II cuticular Hb6
PRO_0000063705

Regions

Region1 – 106106Head
Region107 – 413307Rod
Region107 – 14135Coil 1A
Region142 – 15110Linker 1
Region152 – 252101Coil 1B
Region253 – 26917Linker 12
Region270 – 413144Coil 2
Region414 – 48673Tail

Sequences

Sequence LengthMass (Da)Tools
P97861 [UniParc].

Last modified November 22, 2005. Version 2.
Checksum: 8EABB193B38C8F2A

FASTA48653,251
        10         20         30         40         50         60 
MTCGSYCGGR AFSCASACGP RPGRCCISAA PYRGISCYRG LSGGFGSQSV CGAFRSGSCG 

        70         80         90        100        110        120 
RSFGYRSGGI CGPSPPCITT VSVNESLLTP LNLEIDPNAQ CVKHEEKEQI KCLNSKFAAF 

       130        140        150        160        170        180 
IDKVRFLEQQ NKLLETKWQF YQNRKCCESN MEPLFEGYIE ALRREAECVE ADSGRLAAEL 

       190        200        210        220        230        240 
NHAQESMEGY KKRYEEEVSL RATAENEFVA LKKDVDCAYL RKSDLEANAE ALTQETDFLR 

       250        260        270        280        290        300 
RMYDEETRIL HSHISDTSIV VKMDNSRDLN MDCVVAEIKA QYDDIASRSR AEAESWYRTK 

       310        320        330        340        350        360 
CEEIKATVIR HGETLRRTRE EINELNRMIQ RLTAEIENAK CQNTKLEAAV TQSEQQGEAA 

       370        380        390        400        410        420 
LADARCKLAE LEGALQKAKQ DMACLLKEYQ EVMNSKLGLD VEITTYRRLL EGEEQRLCEG 

       430        440        450        460        470        480 
VGSVNVCVSS SRGGVVCGDL CVSGTAPAVN TRVCSAPCSG NVVVGTPNAC APCAGAGACS 


GGCKKC 

« Hide

References

« Hide 'large scale' references
[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Skin.
[2]"Sequences and differential expression of three novel human type-II hair keratins."
Rogers M.A., Langbein L., Praetzel S., Krieg T., Winter H., Schweizer J.
Differentiation 61:187-194(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 31-486.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK161149 mRNA. Translation: BAE36215.1.
X99143 mRNA. Translation: CAA67580.1.
RefSeqNP_034797.1. NM_010667.2.
UniGeneMm.383183.

3D structure databases

ProteinModelPortalP97861.
SMRP97861. Positions 105-254, 272-412.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid201031. 1 interaction.
STRING10090.ENSMUSP00000085365.

PTM databases

PhosphoSiteP97861.

Proteomic databases

PaxDbP97861.
PRIDEP97861.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000088049; ENSMUSP00000085365; ENSMUSG00000067614.
GeneID16679.
KEGGmmu:16679.
UCSCuc007xti.1. mouse.

Organism-specific databases

CTD3892.
MGIMGI:109362. Krt86.

Phylogenomic databases

eggNOGNOG149039.
GeneTreeENSGT00670000097789.
HOGENOMHOG000230976.
HOVERGENHBG013015.
InParanoidP97861.
KOK07605.
OMACSGGCKK.
OrthoDBEOG7B05CW.
PhylomeDBP97861.
TreeFamTF317854.

Gene expression databases

ArrayExpressP97861.
BgeeP97861.
CleanExMM_KRT86.
GenevestigatorP97861.

Family and domain databases

InterProIPR009030. Growth_fac_rcpt_N_dom.
IPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR003054. Keratin_II.
[Graphical view]
PANTHERPTHR23239. PTHR23239. 1 hit.
PfamPF00038. Filament. 1 hit.
[Graphical view]
PRINTSPR01276. TYPE2KERATIN.
SUPFAMSSF57184. SSF57184. 2 hits.
PROSITEPS00226. IF. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio290421.
PROP97861.
SOURCESearch...

Entry information

Entry nameKRT86_MOUSE
AccessionPrimary (citable) accession number: P97861
Secondary accession number(s): Q3TTV9
Entry history
Integrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: November 22, 2005
Last modified: April 16, 2014
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot