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Protein

Solute carrier family 35 member B1

Gene

Slc35b1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Probable sugar transporter.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Sugar transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 35 member B1
Alternative name(s):
UDP-galactose translocator 2
UDP-galactose transporter-related protein 1
Short name:
UGTrel1
Gene namesi
Name:Slc35b1
Synonyms:Ugalt2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1343133. Slc35b1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei12 – 3221HelicalSequence analysisAdd
BLAST
Transmembranei51 – 7121HelicalSequence analysisAdd
BLAST
Transmembranei85 – 10521HelicalSequence analysisAdd
BLAST
Transmembranei136 – 15621HelicalSequence analysisAdd
BLAST
Transmembranei168 – 18821HelicalSequence analysisAdd
BLAST
Transmembranei210 – 23021HelicalSequence analysisAdd
BLAST
Transmembranei243 – 26321HelicalSequence analysisAdd
BLAST
Transmembranei285 – 30521HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 322322Solute carrier family 35 member B1PRO_0000213367Add
BLAST

Proteomic databases

MaxQBiP97858.
PaxDbiP97858.
PRIDEiP97858.

PTM databases

PhosphoSiteiP97858.

Expressioni

Gene expression databases

BgeeiP97858.
CleanExiMM_SLC35B1.
ExpressionAtlasiP97858. baseline and differential.
GenevisibleiP97858. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000021243.

Structurei

3D structure databases

ProteinModelPortaliP97858.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi318 – 3225Di-lysine motif

Domaini

The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins.By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1580. Eukaryota.
COG0697. LUCA.
GeneTreeiENSGT00530000063090.
HOGENOMiHOG000091197.
HOVERGENiHBG083706.
InParanoidiP97858.
KOiK15275.
OMAiFVCYFYF.
OrthoDBiEOG7FV3QW.
PhylomeDBiP97858.
TreeFamiTF105967.

Family and domain databases

InterProiIPR013657. UAA.
[Graphical view]
PfamiPF08449. UAA. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P97858-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAASRSLVPD RLRLPLCFLG VFVCYFYYGI LQEKITRGKY GEGPKQETFT
60 70 80 90 100
FALTLVFIQC VINAMFAKIL IQFFDTARVD RTRTWLYAAC SVSYVGAMVS
110 120 130 140 150
SNSALQFVNY PTQVLGKSCK PIPVMLLGVT LLKKKYPLAK YLCVLLIVAG
160 170 180 190 200
VALFMYKPKK VVGIEEHTVG FGELLLLMSL TLDGLTGVSQ DHMRAHYQTG
210 220 230 240 250
SNHMMLNINL WSTFLLGAGI LFTGELWEFL SFAERYPTII YNILLFGLTS
260 270 280 290 300
ALGQSFIFMT VVYFGPLTCS IITTTRKFFT ILASVILFAN PISSMQWVGT
310 320
VLVFLGLGLD AKFGKGTKKT SH
Length:322
Mass (Da):35,883
Last modified:May 1, 1997 - v1
Checksum:i3251E99195AAA4A4
GO
Isoform 2 (identifier: P97858-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-97: Missing.

Note: No experimental confirmation available.
Show »
Length:225
Mass (Da):24,820
Checksum:iD42FB49677F84BC6
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 9797Missing in isoform 2. 1 PublicationVSP_016192Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D87990 mRNA. Translation: BAA13526.1.
AK002961 mRNA. Translation: BAC25013.1.
AL662875 Genomic DNA. Translation: CAI25968.1.
BC002029 mRNA. Translation: AAH02029.1.
CCDSiCCDS25277.1. [P97858-1]
PIRiJC5025.
RefSeqiNP_058032.1. NM_016752.1. [P97858-1]
XP_006532048.1. XM_006531985.1. [P97858-2]
UniGeneiMm.4593.

Genome annotation databases

EnsembliENSMUST00000021243; ENSMUSP00000021243; ENSMUSG00000020873. [P97858-1]
GeneIDi110172.
KEGGimmu:110172.
UCSCiuc007lah.1. mouse. [P97858-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D87990 mRNA. Translation: BAA13526.1.
AK002961 mRNA. Translation: BAC25013.1.
AL662875 Genomic DNA. Translation: CAI25968.1.
BC002029 mRNA. Translation: AAH02029.1.
CCDSiCCDS25277.1. [P97858-1]
PIRiJC5025.
RefSeqiNP_058032.1. NM_016752.1. [P97858-1]
XP_006532048.1. XM_006531985.1. [P97858-2]
UniGeneiMm.4593.

3D structure databases

ProteinModelPortaliP97858.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000021243.

PTM databases

PhosphoSiteiP97858.

Proteomic databases

MaxQBiP97858.
PaxDbiP97858.
PRIDEiP97858.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021243; ENSMUSP00000021243; ENSMUSG00000020873. [P97858-1]
GeneIDi110172.
KEGGimmu:110172.
UCSCiuc007lah.1. mouse. [P97858-1]

Organism-specific databases

CTDi10237.
MGIiMGI:1343133. Slc35b1.

Phylogenomic databases

eggNOGiKOG1580. Eukaryota.
COG0697. LUCA.
GeneTreeiENSGT00530000063090.
HOGENOMiHOG000091197.
HOVERGENiHBG083706.
InParanoidiP97858.
KOiK15275.
OMAiFVCYFYF.
OrthoDBiEOG7FV3QW.
PhylomeDBiP97858.
TreeFamiTF105967.

Miscellaneous databases

NextBioi363459.
PROiP97858.
SOURCEiSearch...

Gene expression databases

BgeeiP97858.
CleanExiMM_SLC35B1.
ExpressionAtlasiP97858. baseline and differential.
GenevisibleiP97858. MM.

Family and domain databases

InterProiIPR013657. UAA.
[Graphical view]
PfamiPF08449. UAA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of a novel isoform of the human UDP-galactose transporter, and of related complementary DNAs belonging to the nucleotide-sugar transporter gene family."
    Ishida N., Miura N., Yoshioka S., Kawakita M.
    J. Biochem. 120:1074-1078(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Brain.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: Czech II.
    Tissue: Mammary tumor.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Pancreas.

Entry informationi

Entry nameiS35B1_MOUSE
AccessioniPrimary (citable) accession number: P97858
Secondary accession number(s): Q8CF70
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: May 1, 1997
Last modified: November 11, 2015
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.